1. Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?
- Author
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Pompili, Maurizio, Matthaeis, Nicoletta, Saviano, Antonio, Sio, Ilario, Francica, Giampiero, Brunello, Franco, Cantamessa, Alessandro, Giorgio, Antonio, Scognamiglio, Umberto, Fornari, Fabio, Giangregorio, Francesco, Fabio Piscaglia, Gualandi, Silvia, Caturelli, Eugenio, Roselli, Paola, Riccardi, Laura, Rapaccini, Gian Ludovico, Pompili, Maurizio, De Matthaeis, Nicoletta, Saviano, Antonio, De Sio, Ilario, Francica, Giampiero, Brunello, Franco, Cantamessa, Alessandro, Giorgio, Antonio, Scognamiglio, Umberto, Fornari, Fabio, Giangregorio, Francesco, Piscaglia, Fabio, Gualandi, Silvia, Caturelli, Eugenio, Roselli, Paola, Riccardi, Laura, and Rapaccini, Gian Ludovico
- Subjects
Adult ,Male ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,Prognosi ,liver cirrhosis ,Settore MED/12 - GASTROENTEROLOGIA ,overall survival ,Antineoplastic Agents ,Injections, Intralesional ,Antineoplastic Agent ,Retrospective Studie ,Humans ,neoplasms ,Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Ethanol ,liver cirrhosi ,Settore MED/09 - MEDICINA INTERNA ,Liver Neoplasms ,Middle Aged ,Prognosis ,tumor recurrence ,digestive system diseases ,Tumor Burden ,surgical procedures, operative ,Liver Neoplasm ,Proportional Hazards Model ,Catheter Ablation ,Female ,radiofrequency ablation ,Neoplasm Recurrence, Local ,percutaneous ethanol injection ,Human - Abstract
The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm.Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis.The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group.PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.
- Published
- 2015