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213 results on '"Guo, Hongshan"'

1. Construction of superhydrophobic heterogeneous fiber coalescence materials and emulsion oil removal properties

Author

MA Ning, LI Zhipeng, GUO Hongshan, ZHANG Xiufang, and WANG Xueqing

Subjects
oily wastewater treatment, superhydrophobic material, coalescence, heterofibre-woven material, polytetrafluoroethylene, Environmental technology. Sanitary engineering, TD1-1066
Abstract

In this study,polytetrafluoroethylene(PTFE), a commonly used coalescence oil removal material, was selected and loaded with polyaniline(PANI) on its surface to successfully construct a superhydrophobic fiber material. It was then woven with hydrophilic cotton(Cot) fibers to form a superhydrophobic/hydrophilic heterogeneous material(PANI/PTFE-Cot) for the treatment of oily wastewater. The results indicated that PANI with micro-nano structure was successfully loaded on PTFE fibre, and the dosage of aniline and reaction temperature affected the hydrophobicity of PANI/PTFE. When the reaction temperature was 25 ℃ and the dosage of aniline was 0.2 mol/L,the water contact angle reached its maximum of 154°. Compared with that of PTFE,the quality factor of 2∶1 PANI/PTFE-Cot increased 46.7%.

Published
2024
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8. DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

Author

Guo, Hongshan, Vuille, Joanna A., Wittner, Ben S., Lachtara, Emily M., Hou, Yu, Lin, Maoxuan, Zhao, Ting, Raman, Ayush T., Russell, Hunter C., Reeves, Brittany A., Pleskow, Haley M., Wu, Chin-Lee, Gnirke, Andreas, Meissner, Alexander, Efstathiou, Jason A., Lee, Richard J., Toner, Mehmet, Aryee, Martin J., Lawrence, Michael S., Miyamoto, David T., Maheswaran, Shyamala, and Haber, Daniel A.

Published
2023
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12. Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis

Author

Hu, Yongxian, primary, Zhang, Mingming, additional, Yang, Tingting, additional, Mo, Zhuomao, additional, Wei, Guoqing, additional, Jing, Ruirui, additional, Zhao, Houli, additional, Chen, Rongrong, additional, Zu, Cheng, additional, Gu, Tianning, additional, Xiao, Pingnan, additional, Hong, Ruimin, additional, Feng, Jingjing, additional, Fu, Shan, additional, Kong, Delin, additional, Xu, Huijun, additional, Cui, Jiazhen, additional, Huang, Simao, additional, Liang, Bin, additional, Yuan, Xiaolin, additional, Cui, Qu, additional, Guo, Hongshan, additional, Yu, Yunxian, additional, Feng, Youqin, additional, Jin, Chunxiang, additional, Ren, Jiangtao, additional, Chang, Alex H., additional, Wang, Dongrui, additional, and Huang, He, additional

Published
2024
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14. RNA transcripts stimulate homologous recombination by forming DR-loops

Author

Ouyang, Jian, Yadav, Tribhuwan, Zhang, Jia-Min, Yang, Haibo, Rheinbay, Esther, Guo, Hongshan, Haber, Daniel A., Lan, Li, and Zou, Lee

Subjects
Genetic research, RNA -- Physiological aspects, Genetic recombination -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2 phases of the cell cycle.sup.1-3. Several HR proteins are preferentially recruited to DSBs at transcriptionally active loci.sup.4-10, but how transcription promotes HR is poorly understood. Here we develop an assay to assess the effect of local transcription on HR. Using this assay, we find that transcription stimulates HR to a substantial extent. Tethering RNA transcripts to the vicinity of DSBs recapitulates the effects of local transcription, which suggests that transcription enhances HR through RNA transcripts. Tethered RNA transcripts stimulate HR in a sequence- and orientation-dependent manner, indicating that they function by forming DNA-RNA hybrids. In contrast to most HR proteins, RAD51-associated protein 1 (RAD51AP1) only promotes HR when local transcription is active. RAD51AP1 drives the formation of R-loops in vitro and is required for tethered RNAs to stimulate HR in cells. Notably, RAD51AP1 is necessary for the DSB-induced formation of DNA-RNA hybrids in donor DNA, linking R-loops to D-loops. In vitro, RAD51AP1-generated R-loops enhance the RAD51-mediated formation of D-loops locally and give rise to intermediates that we term 'DR-loops', which contain both DNA-DNA and DNA-RNA hybrids and favour RAD51 function. Thus, at DSBs in transcribed regions, RAD51AP1 promotes the invasion of RNA transcripts into donor DNA, and stimulates HR through the formation of DR-loops. RNA transcripts stimulate homologous recombination through the formation of DR-loops, intermediate structures that contain both DNA-DNA and DNA-RNA hybrids., Author(s): Jian Ouyang [sup.1] , Tribhuwan Yadav [sup.1] , Jia-Min Zhang [sup.1] , Haibo Yang [sup.1] [sup.2] , Esther Rheinbay [sup.1] , Hongshan Guo [sup.1] [sup.3] , Daniel A. Haber [...]

Published
2021
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15. Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

Author

Porter, Rebecca L., Magnus, Neelima K. C., Thapar, Vishal, Morris, Robert, Szabolcs, Annamaria, Neyaz, Azfar, Kulkarni, Anupriya S., Tai, Eric, Chougule, Abhijit, Hillis, Alessandra, Golczer, Gabriel, Guo, Hongshan, Yamada, Teppei, Kurokawa, Tomohiro, Yashaswini, Chittampalli, Ligorio, Matteo, Vo, Kevin D., Nieman, Linda, Liss, Andrew S., Deshpande, Vikram, Lawrence, Michael S., Maheswaran, Shyamala, Castillo, Carlos Fernandez-Del, Hong, Theodore S., Ryan, David P., O’Dwyer, Peter J., Drebin, Jeffrey A., Ferrone, Cristina R., Haber, Daniel A., and Ting, David T.

Published
2019

28. Table S2 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis

Author

Hong, Xin, primary, Roh, Whijae, primary, Sullivan, Ryan J., primary, Wong, Keith H.K., primary, Wittner, Ben S., primary, Guo, Hongshan, primary, Dubash, Taronish D., primary, Sade-Feldman, Moshe, primary, Wesley, Benjamin, primary, Horwitz, Elad, primary, Boland, Genevieve M., primary, Marvin, Dieuwke L., primary, Bonesteel, Todd, primary, Lu, Chenyue, primary, Aguet, François, primary, Burr, Risa, primary, Freeman, Samuel S., primary, Parida, Laxmi, primary, Calhoun, Katherine, primary, Jewett, Michelle K., primary, Nieman, Linda T., primary, Hacohen, Nir, primary, Näär, Anders M., primary, Ting, David T., primary, Toner, Mehmet, primary, Stott, Shannon L., primary, Getz, Gad, primary, Maheswaran, Shyamala, primary, and Haber, Daniel A., primary

Published
2023
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29. Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis

Author

Hong, Xin, primary, Roh, Whijae, primary, Sullivan, Ryan J., primary, Wong, Keith H.K., primary, Wittner, Ben S., primary, Guo, Hongshan, primary, Dubash, Taronish D., primary, Sade-Feldman, Moshe, primary, Wesley, Benjamin, primary, Horwitz, Elad, primary, Boland, Genevieve M., primary, Marvin, Dieuwke L., primary, Bonesteel, Todd, primary, Lu, Chenyue, primary, Aguet, François, primary, Burr, Risa, primary, Freeman, Samuel S., primary, Parida, Laxmi, primary, Calhoun, Katherine, primary, Jewett, Michelle K., primary, Nieman, Linda T., primary, Hacohen, Nir, primary, Näär, Anders M., primary, Ting, David T., primary, Toner, Mehmet, primary, Stott, Shannon L., primary, Getz, Gad, primary, Maheswaran, Shyamala, primary, and Haber, Daniel A., primary

Published
2023
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30. Supplementary Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis

Author

Hong, Xin, primary, Roh, Whijae, primary, Sullivan, Ryan J., primary, Wong, Keith H.K., primary, Wittner, Ben S., primary, Guo, Hongshan, primary, Dubash, Taronish D., primary, Sade-Feldman, Moshe, primary, Wesley, Benjamin, primary, Horwitz, Elad, primary, Boland, Genevieve M., primary, Marvin, Dieuwke L., primary, Bonesteel, Todd, primary, Lu, Chenyue, primary, Aguet, François, primary, Burr, Risa, primary, Freeman, Samuel S., primary, Parida, Laxmi, primary, Calhoun, Katherine, primary, Jewett, Michelle K., primary, Nieman, Linda T., primary, Hacohen, Nir, primary, Näär, Anders M., primary, Ting, David T., primary, Toner, Mehmet, primary, Stott, Shannon L., primary, Getz, Gad, primary, Maheswaran, Shyamala, primary, and Haber, Daniel A., primary

Published
2023
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46. NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

Author

Guo, Hongshan, primary, Golczer, Gabriel, additional, Wittner, Ben S., additional, Langenbucher, Adam, additional, Zachariah, Marcus, additional, Dubash, Taronish D., additional, Hong, Xin, additional, Comaills, Valentine, additional, Burr, Risa, additional, Ebright, Richard Y., additional, Horwitz, Elad, additional, Vuille, Joanna A., additional, Hajizadeh, Soroush, additional, Wiley, Devon F., additional, Reeves, Brittany A., additional, Zhang, Jia-min, additional, Niederhoffer, Kira L., additional, Lu, Chenyue, additional, Wesley, Benjamin, additional, Ho, Uyen, additional, Nieman, Linda T., additional, Toner, Mehmet, additional, Vasudevan, Shobha, additional, Zou, Lee, additional, Mostoslavsky, Raul, additional, Maheswaran, Shyamala, additional, Lawrence, Michael S., additional, and Haber, Daniel A., additional

Published
2021
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47. The DNA methylation landscape of human early embryos

Author

Guo, Hongshan, Zhu, Ping, Yan, Liying, Li, Rong, Hu, Boqiang, Lian, Ying, Yan, Jie, Ren, Xiulian, Lin, Shengli, Li, Junsheng, Jin, Xiaohu, Shi, Xiaodan, Liu, Ping, Wang, Xiaoye, Wang, Wei, Wei, Yuan, Li, Xianlong, Guo, Fan, Wu, Xinglong, Fan, Xiaoying, Yong, Jun, Wen, Lu, Xie, Sunney X., Tang, Fuchou, and Qiao, Jie

Subjects
DNA -- Research, Embryonic development -- Research, Methylation -- Research, Genomes -- Research, Epigenetic inheritance -- Analysis, Genome-wide association studies -- Usage, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic development (1-5). However, its dynamic patterns have not been analysed at the genome scale in human pre-implantation embryos due to technical difficulties and the scarcity of required materials. Here we systematically profile the methylome of human early embryos from the zygotic stage through to post-implantation by reduced representation bisulphite sequencing and whole-genome bisulphite sequencing. We show that the major wave of genome-wide demethylation is complete at the 2-cell stage, contrary to previous observations in mice. Moreover, the demethylation of the paternal genome is much faster than that of the maternal genome, and by the end of the zygotic stage the genome-wide methylation level in male pronuclei is already lower than that in female pronuclei. The inverse correlation between promoter methylation and gene expression gradually strengthens during early embryonic development, reaching its peak at the post-implantation stage. Furthermore, we show that active genes, with the trimethylation of histone H3 at lysine 4 (H3K4me3) mark at the promoter regions in pluripotent human embryonic stem cells, are essentially devoid of DNA methylation in both mature gametes and throughout pre-implantation development. Finally, we also show that long interspersed nuclear elements or short interspersed nuclear elements that are evolutionarily young are demethylated to a milder extent compared to older elements in the same family and have higher abundance of transcripts, indicating that early embryos tend to retain higher residual methylation at the evolutionarily younger and more active transposable elements. Our work provides insights into the critical features of the methylome of human early embryos, as well as its functional relation to the regulation of gene expression and the repression of transposable elements., DNA methylation is an important form of epigenetic modification and has a crucial role in many biological processes, including repression of gene transcription, maintenance of gene imprinting and X-chromosome inactivation, [...]

Published
2014

49. The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis

Author

Hong, Xin, primary, Roh, Whijae, additional, Sullivan, Ryan J., additional, Wong, Keith H.K., additional, Wittner, Ben S., additional, Guo, Hongshan, additional, Dubash, Taronish D., additional, Sade-Feldman, Moshe, additional, Wesley, Benjamin, additional, Horwitz, Elad, additional, Boland, Genevieve M., additional, Marvin, Dieuwke L., additional, Bonesteel, Todd, additional, Lu, Chenyue, additional, Aguet, François, additional, Burr, Risa, additional, Freeman, Samuel S., additional, Parida, Laxmi, additional, Calhoun, Katherine, additional, Jewett, Michelle K., additional, Nieman, Linda T., additional, Hacohen, Nir, additional, Näär, Anders M., additional, Ting, David T., additional, Toner, Mehmet, additional, Stott, Shannon L., additional, Getz, Gad, additional, Maheswaran, Shyamala, additional, and Haber, Daniel A., additional

Published
2021
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