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1. Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy

Author

Nael, Kambiz, Knitter, James R, Jahan, Reza, Gornbein, Jeffery, Ajani, Zahra, Feng, Lei, Meyer, Brett C, Schwamm, Lee H, Yoo, Albert J, Marshall, Randolph S, Meyers, Philip M, Yavagal, Dileep R, Wintermark, Max, Liebeskind, David S, Guzy, Judy, Starkman, Sidney, Saver, Jeffrey L, and Kidwell, Chelsea S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cerebrovascular, Stroke, Brain Disorders, Biomedical Imaging, Neurosciences, Clinical Research, 4.2 Evaluation of markers and technologies, Adolescent, Adult, Aged, Aged, 80 and over, Blood Volume, Brain Ischemia, Cerebral Hemorrhage, Cerebrovascular Circulation, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, ROC Curve, Reperfusion, Tomography, X-Ray Computed, Young Adult, biomarkers, embolectomy, hemorrhage, permeability, stroke, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposePatients with acute ischemic stroke are at increased risk of developing parenchymal hemorrhage (PH), particularly in the setting of reperfusion therapies. We have developed a predictive model to examine the risk of PH using combined magnetic resonance perfusion and diffusion parameters, including cerebral blood volume (CBV), apparent diffusion coefficient, and microvascular permeability (K2).MethodsVoxel-based values of CBV, K2, and apparent diffusion coefficient from the ischemic core were obtained using pretreatment magnetic resonance imaging data from patients enrolled in the MR RESCUE clinical trial (Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy). The associations between PH and extreme values of imaging parameters were assessed in univariate and multivariate analyses. Receiver-operating characteristic curve analysis was performed to determine the optimal parameter(s) and threshold for predicting PH.ResultsIn 83 patients included in this analysis, 20 developed PH. Univariate analysis showed significantly lower 10th percentile CBV and 10th percentile apparent diffusion coefficient values and significantly higher 90th percentile K2 values within the infarction core of patients with PH. Using classification tree analysis, the 10th percentile CBV at threshold of 0.47 and 90th percentile K2 at threshold of 0.28 resulted in overall predictive accuracy of 88.7%, sensitivity of 90.0%, and specificity of 87.3%, which was superior to any individual or combination of other classifiers.ConclusionsOur results suggest that combined 10th percentile CBV and 90th percentile K2 is an independent predictor of PH in patients with acute ischemic stroke with diagnostic accuracy superior to individual classifiers alone. This approach may allow risk stratification for patients undergoing reperfusion therapies.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00389467.

Published
2017

2. A Prehospital Acute Stroke Trial has Only Modest Impact on Enrollment in Concurrent, Post-arrival-Recruiting Stroke Trials

Author

Johnson-Black, Phoebe, Wong, Gregory, Starkman, Sidney, Sanossian, Nerses, Sharma, Latisha, Kim-Tenser, May, Liebeskind, David, Restrepo-Jimenez, Lucas, Valdes-Sueiras, Miguel, Stratton, Samuel, Eckstein, Marc, Pratt, Frank, Conwit, Robin, Hamilton, Scott, Guzy, Judy, Grunberg, Ileana, Shkirkova, Kristina, Hemphill, Claude, III, and Saver, Jeffrey

Published
2020
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3. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author

Demchuk, Andrew, Barber, Philip, Smith, Eric, Bal, Simerpreet, Subramaniam, Suresh, Peters, Steven, Couillard, Phillippe, Klein, Gary, Stys, Peter, Menon, Bijoy, Coutts, Shelagh, Almekhlafi, Mohammed, Hill, Michael, Goyal, Mayank, Wong, John, Mitha, Alim, Eesa, Muneer, Morrish, William, Alqatani, Saad, Kashani, Nima, Joshi, Manish, Zerna, Charlotte, Ospel, Johanna, Venkatesan, Prasanna, Teleg, Erika, Sitaram, Amith, Graham, Brett, Van Gaal, Stephen, Moussaddy, Aimen, Chakraborty, Debabrata, Maraj, Nicholas, Loockey, Andrew, Chen, Shuo, Singh, Ravinder, Alsultan, Abdulaziz, Asuncion, Ria, Tse, Dominic, Doshi, Darshan, Volny, Ondrej, Ojha, Piyush, Wadhwa, Ankur, Marko, Martha, Singh, Nishita, Wasyliw, Sanchea, Ryckborst, Karla, Kenney, Carol, Save, Supriya, Jambula, Anitha, Newcommon, Nancy, Hull, Gavin, Blackstock, Darcy, Kiszczak, Sharon, Zimmel, Leslie, Wright, Michelle, Jahraus, Cari, Andersen, Linda, Bohn, Shelly, Paul, Joseph, Zhang, Oiao, Doram, Craig, Lowerison, Mark, Hanley, Andrea, Campbell, Lori, Ure, Ashley, Taylor, Francis, Hul, Dominic, Wiebe, Samuel, Saluzzi, Marina, Blenkin, Nicole, Frayne, Richard, Buck, Brian, Butcher, Kenneth, Shuaib, Ashfaq, Jeerakathil, Tom, Jickling, Glen, Emery, Derek, Rempel, Jeremy, Owen, Richard, Ashforth, Robert, Yeo, Tom, Kotylak, Trevor, O'Kelly, Cian, Chow, Michael, Siddiqui, Muzaffer, Saqqur, Maher, D'Souza, Atlantic, Lloret, Mar, Butt, Asif, Nomani, Ali, Kalashyan, Hayrapet, Thirunavukkarasu, Sibi, Jabs, Juline, Fairall, Paige, Piquette, Lori, Phillips, Stephen, Green, A. Laine, Gubitz, Gordon, Heidenreich, Jens, Huynh, Thien, Shankar, Jai, Maloney, William, Vandorpe, Robert, Schmidt, Matthias, Pickett, Gwynedd, Weeks, Adrienne, Jarrett, Judith, MacDonald, Debbie, Arsenault, Joanna, Kinnear, Ruth, Mandzia, Jennifer, Mayich, Michael, Boulton, Melfort, Bullrich, Maria, Fridman, Sebastian, Kiwan, Ruba, Lee, Donald, Lownie, Stephen, Khaw, Alexander, Pandey, Sachin, Sharma, Manas, Sposato, Luciano, Wade, Kevin, Beauchamp, Beth, Lambourn, Lindsay, Amato-Marziali, Belinda, Poppe, Alexandre, Roy, Daniel, Daneault, Nicole, Deschaintre, Yan, Gioia, Laura, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Iancu, Daniela, Raymond, Jean, Weill, Alain, Lapierre, Marlène, Jadil, Nadia, Jolteus, Judlène, Teitelbaum, Jeanne, Angle, Mark, Hannouche, Mathew, Badawy, Mohamed, Letourneau, Justin, Cortes, Maria, Linnell, Grant, Tampieri, Donateela, Vieira, Lucy, Legault, Catherine, Durcan, Liam, Moore, Angela, Cole, Erin, Magnussen, Claire, Salmon, Kristiana, Khalil, Salma, Desloges, Isabelle, Waxman, Lindsay, Abdon, Wynne, Lai, Sonia, Dowlatshahi, Dar, Shamy, Michel, Stotts, Grant, Blacquiere, Dylan, Lesiuk, Howard, Quateen, Aiman, Drake, Brian, Dewar, Brian, Daham, Zeinab, Kelly, Michael, Hunter, Gary, Peeling, Lissa, Whelan, Ruth, Garner, Aaron, Urroz, Lilian, Maley, Sharleen, Silver, Frank, Casaubon, Leanne, Pikula, Aleksandra, Del Campo, Martin, Schaafsma, Joanna, Jaigobin, Cheryl, Krings, Timo, Pereira, Vitor, Agid, Ronit, Farb, Richard, Kalman, Libby, Cayley, Anne, Williams, Janice, Stewart, Tim, Misquitta, Karen, Bharatha, Aditya, Selchen, Daniel, Marotta, Thomas, Sarma, Dipanka, Montanera, Walter, Spears, Juluan, Saposnik, Gustavo, Kostyrko, Pawel, Li, Yangmei, Parra-Farina, Carmen, Bengzon Diestro, Jose Danilo, Camden, Marie-Christine, Verreault, Steve, Mackey, Ariane, Audet, Marie-Eve, Milot, Geneviève, Lavoie, Pascale, Gariépy, Jean-Luc, Collard, Karine, Haché, Annette, Van Adel, Brian, Sahlas, Demetrios, Alshanbari, Ahmed, Baldwin, Josephine, Catanese, Luciana, Chen, Bing, De Sa Boasquevisque, Danielle, Deshmukh, Aviraj, Knapman, Jordan, Lamers, Shana, Larrazabal, Ramiro, MacMillan, Susan, Mai, Lauren, Mattia, Alicia, Nayar, Sumiti, Ng, Kuan, Oczkowski, Wieslaw, Perera, Kanjana, Shawawrah, Mays, Shoamanesh, Ashkan, Sobhi, Gita, Syed, Nabeel, Taher, Noran, Vandervelde, Cheyanne, Wang Pharm, Di, Field, Thalia, Teal, Philip, Benavente, Oscar, Wilson, Laura, Mann, Sharanpal, Yip, Samuel, Murphy, Colleen, Heran, Manraj, Rohr, Axel, Settecase, Fabio, Redekop, Gary, Haw, Charles, Maclean, Genoveva, Murray, Karina, Chiu, Rosalin, Flexman, Alana, Strecha, Eilidh, Gayton, Yolanda, Yip, Judy, Swartz, Richard, Boulos, Mark, Gladstone, David, Yu, Amy, Hopyan, Julia, Khosravani, Houman, Manosalva Alzate, Herbert, Southwell, Alisia, Kamra, Maneesha, Lopes, Kaitlyn, Kapoor, Arunima, da Costa, Leodante, Yang, Victor, Dyer, Erin, Shah, Ruchir, Knowles, Brenda, Nichols, Jennifer, Patterson, Jennifer, Cope, Krista, Dickerson, Lee, Barton, Katrina, Gray, Kimberly, Massengale, Ticey, Miller, Melanie, Simpson, Cindy, Walker, Sabrina, Tennyson-Yemm, Chlin, Devlin, Thomas, Frei, Donald, Bellon, Richard, Atchie, Benjamin, Kaminsky, Ian, Wilson, Duandelyn, Schraeder, Nicolle, Arias, Eric, Kodis, Lisa, Talley, Mark, Edinger, Alex, Talley, Tiffany, Dempsey, Ita, Williams, Laurie, Williams, Scott, Kupniewski, Sonny, Fasbinder, Brad, Snead, Joanna, Choe, Hana, Mackenzie, Larami, Weisman, Davi, Kozak, Osman, Shah, Qaisar, Gzesh, Dan, Kulandaivel, Kandan, Khoury, John, Klein, Brad, Bussinger, Patricia, Griffin, Lisa, dePalmo, Ashley, Oliva, Cynthia, Jadhav, Ashutosh, Jovin, Tudor, Kenmuir, Cynthia, Jankowitz, Brian, Gross, Bradley, Rocha, Marcelo, Starr, Matthew, Brown, Merritt, Hawkes, Christine, Shah, Kavit, Tememe, Danoushka, Walker, Gregory, Patel, Pratit, Klein, Bradley, Ziayee, Habibullah, Limaye, Kaustubh, Baxendell, Lisa, Gilchrist, Vicki, Feineigle, Patricia, Toseki Haibach, Kelsea, Van Every, Cathy, Desai, Shashyat, Zulfiqar, Maryam, Gibson, Linda, Barrett, Sean, Turkel-Parrella, David, Arcot, Karthikeyan, DiCrescento, Steven, Farkas, Jeffrey, Filipowski, Gregory, Frontera, Jennifer, Joset, Danielle, Liff, Jeremy, Scher, Erica, McDougall, Cameron, Kelly, Cheryl, Patel, Akshal, Monteith, Stephen, Starkman, Sidney, Atchaneeyasakul, Kunakorn, Burgos, Adrian, Chua, Janice Anne, Gaines, Nathan, Grunberg, Ileana, Guzy, Judy, Liu, Zuolu, Maluste, Neil, Ramirez, Lucas, Sharma, Latisha, Heck, Donald, Brown, Morry, McDonald, Colin, Calderon, Mateo, Hargis, Mitch, Roels, Christina, Emmady, Prabhu, Alvi, Talat, McTaggart, Ryan, Jayaraman, Mahesh, Cutting, Shawna, Smith, Wendy, Foley, Susan, Paolucci, Gino, Has, Richard, Quinn, Katie, Fuller, Lindsey, Brierley, Rebecca, Watkins, Christina, Demir, Nicole, Lopez, George, Vargas, Alejandro, Osteraas, Nicholas, Holtz, Becky, Sauvageau, Eric, Hanel, Ricardo, Aghaebrahim, Amin, Chmayssani, Mohamad, Naval, Neeraj, Day, Jason, Dellorso, Scott, Ludwig, Benjamin, Schemmel, Derek, Ebreo, Nancy, Bell, Karen, Lewis, Lanai, Delucia, Marjorie, Nogueira, Raul, Haussen, Diogo, Frankel, Michael, Bhatt, Nirav, Bianchi, Nicolas, Anderson, Aaron, Belagaje, Samir, Liberato, Bernardo, Rangaraju, Srikant, Al-Bayati, Alhamza, Grossberg, Jonathan, Craft, Leah, Schindler, Kiva, Schaad, Erin, Schultz, Meagan, Southerly, Lorretta, Doppelheuer, Shannon, Charlton, Jacquelyn, Faggard, Jason, Barbret, Zuzana, DukSoo Han, Ethan, Walters, Robin, Dolia, Jaydevsinh, El-Jamal, Sleiman, Eby, Brendan, Saleem, Yasir, Pearl, Harrison, Patel, Kishan, Rahman, Haseeb, Butt, Reema, English, Stephen, Puri, Ajit, Howk, Mary, Singh, Jasmeet, Massari, Francesco, DeMacedo Rodrigues, Katyucia, Kuhn, Anna, English, Joey, Barazangi, Nobl, Telischak, Nick, Kim, Warren, Ross, Josh, DeVole, Nata, Redford, Jessica, Ferreira, Milena, Ponting, Katie, Shen, Helen, Bedenk, Ann, Patel, Susila, Fernandess, Julia, Ke, Michael, Spokoyny, Ilanit, Gao, Billy, Tong, David, Chen, Charlene, Wong, Christine, Choe, Jessica, Martin, Coleman, Summers, Debbie, Boutwell, Christine, Olds, Karin, Crandall, Suzanne, Eatman, John, Akhtar, Naveed, Holloway, William, Halpin, Jared, Donegan, Brett, Schindler, Joseph, Hwang, David, Gilmore, Emily, Petersen, Nils, Sheth, Kevin, Brown, Stacy, Beekman, Rachel, George, Benjamin, Kaddouh, Firas, Falcone, Guido, Wira, Charles, Matouk, Charles, Loomis, Caitlin, Amin, Hardik, Stretz, Hans Christoph, Narula, Reshma, Jasne, Adam, Sansing, Lauren, Agarwal, Tijil, Jasak, Sara, Fontaine, Briana, King, Zachary, Kuohn, Lindsey, Orgass, Hailey, Leary, Megan, Nye, Joan, Halbert, Kelsey, Nystrom, Karin, Neuschatz, Kaile, Petrucci, Dawn, Coppola, Anna, Tarpley, Jason, Joyce, Treasure, Hou, Sam, Umekubo, Mark, Nakamura, Catrice, Ovando, Renee, Zuniga, Diana, Nien, Yih Lin, Basto, Fernando Mayor, Arch, Allison, Jong, Laura, Conrad, William, Abbott, Tara, Yao, Jay, Caganap, Scott, Jordan, John, Teitelbaum, George, Darflinger, Robert, Gupta, Rishi, Bain, Marianne, Budzik, Ronald, Czerniak, Jennifer, Groezinger, Katherine, Hicks II, William, Kaskar, Omran, Katz, Brian, Loochtan, Aaron, Pema, Peter, Rai, Vivek, Vora, Nirav, Brown, Amanda, Goodman, Diane, Danenbergs, Barb, Gossett, Monica, Bang, Oh Young, Chung, Jong-Won, Jeon, Pyoung, Kim, Keon Ha, Lim, Yun Jeong, Heo, Ji Hoe, Nam, Hyo Suk, Kim, Young Dae, Park, HyungJong, Hwang, In Gun, Ha, Wooseok, Choi, Jin Kyo, Jeong, Kyungsun, Rha, Joung-Ho, Park, Hee-Kwon, Yoon, Cindy, Kim, Bo-Kyung, Sohn, Sung-Il, Kim, Chang-hyun, Yoo, Joonsang, Hong, Jeong-Ho, Park, Hyungjong, Kim, Sohyeon, Choi, Moonkyung, Bae, Hyoeun, Lee, Jun Seok, Lee, Jae-Joon, Jun, Go-Eun, Jeon, Sujeong, Campbell, Bruce, Mitchell, Peter, Yassi, Nawaf, Davis, Stephen, Donnan, Geoffrey, Parsons, Mark, Yan, Bernard, Dowling, Richard, Bush, Steven, Wu, Teddy, Shah, Darshan, Zhao, Henry, Salvaris, Patrick, Alemseged, Fana, Ng, Felix, Williams, Cameron, Balabanski, Anna, Dos Santos, Angela, Ng, Jo-Lyn, McDonald, Amy, Jackson, David, Tsoleridis, Jessica, Pesavento, Lauren, Kleinig, Timothy John, Nurs, Roy Drew, Cranefield, Jennifer, Scroop, Rebecca, Cagi, Lavenia, Harvey, Jackson, Waters, Michael, Thornton, John, Brennan, Robert, O'Hare, Alan, Power, Sarah, Williams, David, Boyle, Karl, Moynihan, Barry, Liddy, Ann-Marie, Large, Margaret, Cullen, Ailbhe, Walsh, Roisin, Martin, Emma, Lynch, Julie, McElroy, Sinéad, Murphy, Seán, Coveney, Sarah, Deegan, Caroline, Horgan, Gillian, Kelly, Peter, Laffan, Aoife, Llamas-Osorio, Yudy, Lynch, Catherine, Mac Mahon, Peter, Marnane, Michael, McCabe, John, Burns, Paul, Tauro, Suzanne, Cuddy, Sarah, Rennie, Ian, Smyth, Graham, Flynn, Peter, Wiggam, Ivan, Kerr, Enda, Gordon, Patricia, Fearon, Patricia, Roberts, Geralt, Patterson, Cathy, Adams, Karen, Wells, Brian, McFarland, Margaret, Holmin, Staffan, Moreira, Tiago, Sjöstrand, Christina, Mazya, Michael, Almqvist, Håkan, Wahlgren, Nils, Steinberg, Anna, Cooray, Charith, Eriksson, Einar, Thorén, Magnus, Keselman, Boris, Ahmed, NIaz, Holmberg, Åke, Axelsson, Maria, Berglund, Annika, Thomalla, Götz, Golsari, Amir, Hoppe, Julia, Deb-Chatterji, Milani, Cheng, Bastian, Barrow, Ewgenia, Schlemm, Eckhard, Lettow, Iris, Jensen, Märit, Otto, Dagmar, Jaramillo, Kirsten, Appelbohm, Hannes, Fiehler, Jens, Bester, Maxim, Schönfeld, Michael, Brekenfeld, Caspar, Holst, Brigitte, Wortmann, Ginette, Koch, Friederike, Puetz, Volker, Gerber, Johannes, Abramyuk, Andrij, Kaiser, Daniel, Winzer, Simon, Prakapenia, Alexandra, Pallesen, Lars-Peder, Siepmann, Timo, Barlinn, Kristian, Haase, Kathrin, Sauer, Angela, Psychogios, Marios-Nikos, Liman, Jan, Brehm, Alex, Maus, Volker, Hollstein, Nicole, Reinke, Annika, Neitz, Gustav, Schnieder, Marlena, Schwarz, Margret, Ibrahim, Allam, Müller, Julia, Meister, Stefanie, Bäumle, Berit, Chapot, René, Pilgram-Pastor, Sara, Wallocha, Marta, Stauder, Michael, Celik, Ekin, Stracke, Paul, Müller, Nicole, Weber, Ralph, Velktamp, Roland, Nagel, Simon, Ringleb, Peter Arthur, Heyse, Miriam, Amiri, Hemasse, Mundiyanapurath, Sibu, Chen, Min, Bevrle, Elisabeth, Beck, Perdita, Möhlenbruch, Markus alfred, Tymianski, Michael, Potvin, Alphonse, Harris, Cameron, Wang, Chong, Adams, Corey, Mayor, Diana, Garman, Dave, Chau, Davis, Wu, Jane, Lunn, Janet, Heard, Kathy, Bermanis, Liat, Teyes, Lucy, Constant, Marc, Galsim, Maria, Helbin, Michael, Leroux, Michelle, Felix, Nicole, Bendre, Nilima, Cuthbert, Sandra, Brokx, Steve, Zhang, Yichuan, Lingham, Trudy, Kohli, Yatika, Salter, Michael, Liebeschuetz, Joseph, Hofmann, Frieder, Constant, John, Soeder, Tom, Snoke, Kara, Bologa, Monica, Stahl, Kimberly, Graziewicz, Maria, Hill, Michael D, Menon, Bijoy K, Nogueira, Raul G, McTaggart, Ryan A, Demchuk, Andrew M, Poppe, Alexandre Y, Buck, Brian H, Field, Thalia S, van Adel, Brian A, Swartz, Richard H, Shah, Ruchir A, Ospel, Johanna M, Almekhlafi, Mohammed A, Ryckborst, Karla J, Lowerison, Mark W, Garman, David, Cutting, Shawna M, Coutts, Shelagh B, Rempel, Jeremy L, Rohr, Axel CR, Sahlas, Demetrios J, Yu, Amy Y X, Devlin, Thomas G, Hanel, Ricardo A, Silver, Frank L, Campbell, Bruce C V, Mandzia, Jennifer L, Kleinig, Timothy J, Kelly, Michael E, Frei, Donald F, Tarpley, Jason W, McDougall, Cameron G, Puri, Ajit S, Phillips, Stephen J, Schindler, Joseph L, Budzik, Ronald F, Martin, Coleman O, Burns, Paul A, and Lopez, George A

Published
2020
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4. Enrollment bias: frequency and impact on patient selection in endovascular stroke trials.

Author

Sheth, Sunil A, Saver, Jeffrey L, Starkman, Sidney, Grunberg, Ileana D, Guzy, Judy, Ali, Latisha K, Kim, Doojin, Gonzalez, Nestor R, Jahan, Reza, Tateshima, Satoshi, Duckwiler, Gary, and Liebeskind, David S

Subjects
Humans, Cohort Studies, Prospective Studies, Patient Selection, Time Factors, Aged, Aged, 80 and over, Middle Aged, Female, Male, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Stroke, Endovascular Procedures, Bias, Angiography, Intervention, Political, Standards, Thrombectomy
Abstract

BackgroundSelection bias may have affected enrollment in first generation endovascular stroke trials. We investigate, evaluate, and quantify such bias for these trials at our institution.MethodsDemographic, clinical, imaging, and angiographic data were prospectively collected on a consecutive cohort of patients with acute ischemic stroke who were enrolled in formal trials of endovascular stroke therapy (EST) or received EST in clinical practice outside of a randomized trial for acute cerebral ischemia at a single tertiary referral center from September 2004 to December 2012.ResultsAmong patients considered appropriate for EST in practice, 47% were eligible for trials, with rates for individual trials ranging from 17% to 70%. Compared with trial ineligible patients treated with EST, trial eligible patients were younger (67 vs. 74 years; p

Published
2016

5. Frequency, Determinants, and Outcomes of Emboli to Distal and New Territories Related to Mechanical Thrombectomy for Acute Ischemic Stroke

Author

Wong, Gregory J., primary, Yoo, Bryan, additional, Liebeskind, David, additional, Baharvahdat, Humain, additional, Gornbein, Jeffrey, additional, Jahan, Reza, additional, Szeder, Viktor, additional, Duckwiler, Gary, additional, Tateshima, Satoshi, additional, Colby, Geoffrey, additional, Nour, May, additional, Sharma, Latisha, additional, Rao, Neal, additional, Hinman, Jason, additional, Starkman, Sidney, additional, Saver, Jeffrey L., additional, Alfonso, Rodel, additional, Arch, Allison, additional, Avila, Gilda, additional, Hosseini, Mersedeh Bahr, additional, Chatfield, Fionna, additional, Chhabra, Arun S., additional, Dobkin, Bruce, additional, Frischmann, Lindsey K., additional, Grunberg, Ileana, additional, Guzy, Judy, additional, Huang, Josephine F., additional, Kim, Doojin, additional, Malhotra, Konark, additional, McManus, Michael, additional, Restrepo, Lucas, additional, Singh, Parampreet, additional, Tang, Xiannan (Xander), additional, Tarpley, Jason W., additional, and Tipirneni, Anita, additional

Published
2021
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6. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author

Hill, Michael D, primary, Goyal, Mayank, additional, Menon, Bijoy K, additional, Nogueira, Raul G, additional, McTaggart, Ryan A, additional, Demchuk, Andrew M, additional, Poppe, Alexandre Y, additional, Buck, Brian H, additional, Field, Thalia S, additional, Dowlatshahi, Dar, additional, van Adel, Brian A, additional, Swartz, Richard H, additional, Shah, Ruchir A, additional, Sauvageau, Eric, additional, Zerna, Charlotte, additional, Ospel, Johanna M, additional, Joshi, Manish, additional, Almekhlafi, Mohammed A, additional, Ryckborst, Karla J, additional, Lowerison, Mark W, additional, Heard, Kathy, additional, Garman, David, additional, Haussen, Diogo, additional, Cutting, Shawna M, additional, Coutts, Shelagh B, additional, Roy, Daniel, additional, Rempel, Jeremy L, additional, Rohr, Axel CR, additional, Iancu, Daniela, additional, Sahlas, Demetrios J, additional, Yu, Amy Y X, additional, Devlin, Thomas G, additional, Hanel, Ricardo A, additional, Puetz, Volker, additional, Silver, Frank L, additional, Campbell, Bruce C V, additional, Chapot, René, additional, Teitelbaum, Jeanne, additional, Mandzia, Jennifer L, additional, Kleinig, Timothy J, additional, Turkel-Parrella, David, additional, Heck, Donald, additional, Kelly, Michael E, additional, Bharatha, Aditya, additional, Bang, Oh Young, additional, Jadhav, Ashutosh, additional, Gupta, Rishi, additional, Frei, Donald F, additional, Tarpley, Jason W, additional, McDougall, Cameron G, additional, Holmin, Staffan, additional, Rha, Joung-Ho, additional, Puri, Ajit S, additional, Camden, Marie-Christine, additional, Thomalla, Götz, additional, Choe, Hana, additional, Phillips, Stephen J, additional, Schindler, Joseph L, additional, Thornton, John, additional, Nagel, Simon, additional, Heo, Ji Hoe, additional, Sohn, Sung-Il, additional, Psychogios, Marios-Nikos, additional, Budzik, Ronald F, additional, Starkman, Sidney, additional, Martin, Coleman O, additional, Burns, Paul A, additional, Murphy, Seán, additional, Lopez, George A, additional, English, Joey, additional, Tymianski, Michael, additional, Demchuk, Andrew, additional, Barber, Philip, additional, Smith, Eric, additional, Bal, Simerpreet, additional, Subramaniam, Suresh, additional, Peters, Steven, additional, Couillard, Phillippe, additional, Klein, Gary, additional, Stys, Peter, additional, Menon, Bijoy, additional, Coutts, Shelagh, additional, Almekhlafi, Mohammed, additional, Hill, Michael, additional, Wong, John, additional, Mitha, Alim, additional, Eesa, Muneer, additional, Morrish, William, additional, Alqatani, Saad, additional, Kashani, Nima, additional, Ospel, Johanna, additional, Venkatesan, Prasanna, additional, Teleg, Erika, additional, Sitaram, Amith, additional, Graham, Brett, additional, Van Gaal, Stephen, additional, Moussaddy, Aimen, additional, Chakraborty, Debabrata, additional, Maraj, Nicholas, additional, Loockey, Andrew, additional, Chen, Shuo, additional, Singh, Ravinder, additional, Alsultan, Abdulaziz, additional, Asuncion, Ria, additional, Tse, Dominic, additional, Doshi, Darshan, additional, Volny, Ondrej, additional, Ojha, Piyush, additional, Wadhwa, Ankur, additional, Marko, Martha, additional, Singh, Nishita, additional, Wasyliw, Sanchea, additional, Ryckborst, Karla, additional, Kenney, Carol, additional, Save, Supriya, additional, Jambula, Anitha, additional, Newcommon, Nancy, additional, Hull, Gavin, additional, Blackstock, Darcy, additional, Kiszczak, Sharon, additional, Zimmel, Leslie, additional, Wright, Michelle, additional, Jahraus, Cari, additional, Andersen, Linda, additional, Bohn, Shelly, additional, Paul, Joseph, additional, Zhang, Oiao, additional, Doram, Craig, additional, Lowerison, Mark, additional, Hanley, Andrea, additional, Campbell, Lori, additional, Ure, Ashley, additional, Taylor, Francis, additional, Hul, Dominic, additional, Wiebe, Samuel, additional, Saluzzi, Marina, additional, Blenkin, Nicole, additional, Frayne, Richard, additional, Buck, Brian, additional, Butcher, Kenneth, additional, Shuaib, Ashfaq, additional, Jeerakathil, Tom, additional, Jickling, Glen, additional, Emery, Derek, additional, Rempel, Jeremy, additional, Owen, Richard, additional, Ashforth, Robert, additional, Yeo, Tom, additional, Kotylak, Trevor, additional, O'Kelly, Cian, additional, Chow, Michael, additional, Siddiqui, Muzaffer, additional, Saqqur, Maher, additional, D'Souza, Atlantic, additional, Lloret, Mar, additional, Butt, Asif, additional, Nomani, Ali, additional, Kalashyan, Hayrapet, additional, Thirunavukkarasu, Sibi, additional, Jabs, Juline, additional, Fairall, Paige, additional, Piquette, Lori, additional, Phillips, Stephen, additional, Green, A. Laine, additional, Gubitz, Gordon, additional, Heidenreich, Jens, additional, Huynh, Thien, additional, Shankar, Jai, additional, Maloney, William, additional, Vandorpe, Robert, additional, Schmidt, Matthias, additional, Pickett, Gwynedd, additional, Weeks, Adrienne, additional, Jarrett, Judith, additional, MacDonald, Debbie, additional, Arsenault, Joanna, additional, Kinnear, Ruth, additional, Mandzia, Jennifer, additional, Mayich, Michael, additional, Boulton, Melfort, additional, Bullrich, Maria, additional, Fridman, Sebastian, additional, Kiwan, Ruba, additional, Lee, Donald, additional, Lownie, Stephen, additional, Khaw, Alexander, additional, Pandey, Sachin, additional, Sharma, Manas, additional, Sposato, Luciano, additional, Wade, Kevin, additional, Beauchamp, Beth, additional, Lambourn, Lindsay, additional, Amato-Marziali, Belinda, additional, Poppe, Alexandre, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Gioia, Laura, additional, Jacquin, Grégory, additional, Odier, Céline, additional, Stapf, Christian, additional, Raymond, Jean, additional, Weill, Alain, additional, Lapierre, Marlène, additional, Jadil, Nadia, additional, Jolteus, Judlène, additional, Angle, Mark, additional, Hannouche, Mathew, additional, Badawy, Mohamed, additional, Letourneau, Justin, additional, Cortes, Maria, additional, Linnell, Grant, additional, Tampieri, Donateela, additional, Vieira, Lucy, additional, Legault, Catherine, additional, Durcan, Liam, additional, Moore, Angela, additional, Cole, Erin, additional, Magnussen, Claire, additional, Salmon, Kristiana, additional, Khalil, Salma, additional, Desloges, Isabelle, additional, Waxman, Lindsay, additional, Abdon, Wynne, additional, Lai, Sonia, additional, Shamy, Michel, additional, Stotts, Grant, additional, Blacquiere, Dylan, additional, Lesiuk, Howard, additional, Quateen, Aiman, additional, Drake, Brian, additional, Dewar, Brian, additional, Daham, Zeinab, additional, Kelly, Michael, additional, Hunter, Gary, additional, Peeling, Lissa, additional, Whelan, Ruth, additional, Garner, Aaron, additional, Urroz, Lilian, additional, Maley, Sharleen, additional, Silver, Frank, additional, Casaubon, Leanne, additional, Pikula, Aleksandra, additional, Del Campo, Martin, additional, Schaafsma, Joanna, additional, Jaigobin, Cheryl, additional, Krings, Timo, additional, Pereira, Vitor, additional, Agid, Ronit, additional, Farb, Richard, additional, Kalman, Libby, additional, Cayley, Anne, additional, Williams, Janice, additional, Stewart, Tim, additional, Misquitta, Karen, additional, Selchen, Daniel, additional, Marotta, Thomas, additional, Sarma, Dipanka, additional, Montanera, Walter, additional, Spears, Juluan, additional, Saposnik, Gustavo, additional, Kostyrko, Pawel, additional, Li, Yangmei, additional, Parra-Farina, Carmen, additional, Bengzon Diestro, Jose Danilo, additional, Verreault, Steve, additional, Mackey, Ariane, additional, Audet, Marie-Eve, additional, Milot, Geneviève, 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Yip, Samuel, additional, Murphy, Colleen, additional, Heran, Manraj, additional, Rohr, Axel, additional, Settecase, Fabio, additional, Redekop, Gary, additional, Haw, Charles, additional, Maclean, Genoveva, additional, Murray, Karina, additional, Chiu, Rosalin, additional, Flexman, Alana, additional, Strecha, Eilidh, additional, Gayton, Yolanda, additional, Yip, Judy, additional, Swartz, Richard, additional, Boulos, Mark, additional, Gladstone, David, additional, Yu, Amy, additional, Hopyan, Julia, additional, Khosravani, Houman, additional, Manosalva Alzate, Herbert, additional, Southwell, Alisia, additional, Kamra, Maneesha, additional, Lopes, Kaitlyn, additional, Kapoor, Arunima, additional, da Costa, Leodante, additional, Yang, Victor, additional, Dyer, Erin, additional, Shah, Ruchir, additional, Knowles, Brenda, additional, Nichols, Jennifer, additional, Patterson, Jennifer, additional, Cope, Krista, additional, Dickerson, Lee, additional, Barton, Katrina, additional, Gray, Kimberly, additional, Massengale, Ticey, additional, Miller, Melanie, additional, Simpson, Cindy, additional, Walker, Sabrina, additional, Tennyson-Yemm, Chlin, additional, Devlin, Thomas, additional, Frei, Donald, additional, Bellon, Richard, additional, Atchie, Benjamin, additional, Kaminsky, Ian, additional, Wilson, Duandelyn, additional, Schraeder, Nicolle, additional, Arias, Eric, additional, Kodis, Lisa, additional, Talley, Mark, additional, Edinger, Alex, additional, Talley, Tiffany, additional, Dempsey, Ita, additional, Williams, Laurie, additional, Williams, Scott, additional, Kupniewski, Sonny, additional, Fasbinder, Brad, additional, Snead, Joanna, additional, Mackenzie, Larami, additional, Weisman, Davi, additional, Kozak, Osman, additional, Shah, Qaisar, additional, Gzesh, Dan, additional, Kulandaivel, Kandan, additional, Khoury, John, additional, Klein, Brad, additional, Bussinger, Patricia, additional, Griffin, Lisa, additional, dePalmo, Ashley, additional, Oliva, Cynthia, additional, Jovin, Tudor, additional, Kenmuir, Cynthia, additional, Jankowitz, Brian, additional, Gross, Bradley, additional, Rocha, Marcelo, additional, Starr, Matthew, additional, Brown, Merritt, additional, Hawkes, Christine, additional, Shah, Kavit, additional, Tememe, Danoushka, additional, Walker, Gregory, additional, Patel, Pratit, additional, Klein, Bradley, additional, Ziayee, Habibullah, additional, Limaye, Kaustubh, additional, Baxendell, Lisa, additional, Gilchrist, Vicki, additional, Feineigle, Patricia, additional, Toseki Haibach, Kelsea, additional, Van Every, Cathy, additional, Desai, Shashyat, additional, Zulfiqar, Maryam, additional, Gibson, Linda, additional, Barrett, Sean, additional, Arcot, Karthikeyan, additional, DiCrescento, Steven, additional, Farkas, Jeffrey, additional, Filipowski, Gregory, additional, Frontera, Jennifer, additional, Joset, Danielle, additional, Liff, Jeremy, additional, Scher, Erica, additional, McDougall, Cameron, additional, Kelly, Cheryl, additional, Patel, Akshal, additional, Monteith, Stephen, additional, Atchaneeyasakul, Kunakorn, additional, Burgos, Adrian, additional, Chua, Janice Anne, additional, Gaines, Nathan, additional, Grunberg, Ileana, additional, Guzy, Judy, additional, Liu, Zuolu, additional, Maluste, Neil, additional, Ramirez, Lucas, additional, Sharma, Latisha, additional, Brown, Morry, additional, McDonald, Colin, additional, Calderon, Mateo, additional, Hargis, Mitch, additional, Roels, Christina, additional, Emmady, Prabhu, additional, Alvi, Talat, additional, McTaggart, Ryan, additional, Jayaraman, Mahesh, additional, Cutting, Shawna, additional, Smith, Wendy, additional, Foley, Susan, additional, Paolucci, Gino, additional, Has, Richard, additional, Quinn, Katie, additional, Fuller, Lindsey, additional, Brierley, Rebecca, additional, Watkins, Christina, additional, Demir, Nicole, additional, Lopez, George, additional, Vargas, Alejandro, additional, Osteraas, Nicholas, additional, Holtz, Becky, additional, Hanel, Ricardo, additional, Aghaebrahim, Amin, additional, Chmayssani, Mohamad, additional, Naval, Neeraj, additional, Day, Jason, additional, Dellorso, Scott, additional, Ludwig, Benjamin, additional, Schemmel, Derek, additional, Ebreo, Nancy, additional, Bell, Karen, additional, Lewis, Lanai, additional, Delucia, Marjorie, additional, Nogueira, Raul, additional, Frankel, Michael, additional, Bhatt, Nirav, additional, Bianchi, Nicolas, additional, Anderson, Aaron, additional, Belagaje, Samir, additional, Liberato, Bernardo, additional, Rangaraju, Srikant, additional, Al-Bayati, Alhamza, additional, Grossberg, Jonathan, additional, Craft, Leah, additional, Schindler, Kiva, additional, Schaad, Erin, additional, Schultz, Meagan, additional, Southerly, Lorretta, additional, Doppelheuer, Shannon, additional, Charlton, Jacquelyn, additional, Faggard, Jason, additional, Barbret, Zuzana, additional, DukSoo Han, Ethan, additional, Walters, Robin, additional, Dolia, 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Boutwell, Christine, additional, Olds, Karin, additional, Crandall, Suzanne, additional, Eatman, John, additional, Akhtar, Naveed, additional, Holloway, William, additional, Halpin, Jared, additional, Donegan, Brett, additional, Schindler, Joseph, additional, Hwang, David, additional, Gilmore, Emily, additional, Petersen, Nils, additional, Sheth, Kevin, additional, Brown, Stacy, additional, Beekman, Rachel, additional, George, Benjamin, additional, Kaddouh, Firas, additional, Falcone, Guido, additional, Wira, Charles, additional, Matouk, Charles, additional, Loomis, Caitlin, additional, Amin, Hardik, additional, Stretz, Hans Christoph, additional, Narula, Reshma, additional, Jasne, Adam, additional, Sansing, Lauren, additional, Agarwal, Tijil, additional, Jasak, Sara, additional, Fontaine, Briana, additional, King, Zachary, additional, Kuohn, Lindsey, additional, Orgass, Hailey, additional, Leary, Megan, additional, Nye, Joan, additional, Halbert, Kelsey, additional, Nystrom, Karin, additional, Neuschatz, Kaile, additional, Petrucci, Dawn, additional, Coppola, Anna, additional, Tarpley, Jason, additional, Joyce, Treasure, additional, Hou, Sam, additional, Umekubo, Mark, additional, Nakamura, Catrice, additional, Ovando, Renee, additional, Zuniga, Diana, additional, Nien, Yih Lin, additional, Basto, Fernando Mayor, additional, Arch, Allison, additional, Jong, Laura, additional, Conrad, William, additional, Abbott, Tara, additional, Yao, Jay, additional, Caganap, Scott, additional, Jordan, John, additional, Teitelbaum, George, additional, Darflinger, Robert, additional, Bain, Marianne, additional, Budzik, Ronald, additional, Czerniak, Jennifer, additional, Groezinger, Katherine, additional, Hicks II, William, additional, Kaskar, Omran, additional, Katz, Brian, additional, Loochtan, Aaron, additional, Pema, Peter, additional, Rai, Vivek, additional, Vora, Nirav, additional, Brown, Amanda, additional, Goodman, Diane, additional, Danenbergs, Barb, additional, Gossett, Monica, additional, Chung, Jong-Won, additional, Jeon, Pyoung, additional, Kim, Keon Ha, additional, Lim, Yun Jeong, additional, Nam, Hyo Suk, additional, Kim, Young Dae, additional, Park, HyungJong, additional, Hwang, In Gun, additional, Ha, Wooseok, additional, Choi, Jin Kyo, additional, Jeong, Kyungsun, additional, Park, Hee-Kwon, additional, Yoon, Cindy, additional, Kim, Bo-Kyung, additional, Kim, Chang-hyun, additional, Yoo, Joonsang, additional, Hong, Jeong-Ho, additional, Park, Hyungjong, additional, Kim, Sohyeon, additional, Choi, Moonkyung, additional, Bae, Hyoeun, additional, Lee, Jun Seok, additional, Lee, Jae-Joon, additional, Jun, Go-Eun, additional, Jeon, Sujeong, additional, Campbell, Bruce, additional, Mitchell, Peter, additional, Yassi, Nawaf, additional, Davis, Stephen, additional, Donnan, Geoffrey, additional, Parsons, Mark, additional, Yan, Bernard, additional, Dowling, Richard, additional, Bush, Steven, additional, Wu, Teddy, additional, Shah, Darshan, additional, Zhao, Henry, additional, Salvaris, Patrick, additional, Alemseged, Fana, additional, Ng, Felix, additional, Williams, Cameron, additional, Balabanski, Anna, additional, Dos Santos, Angela, additional, Ng, Jo-Lyn, additional, McDonald, Amy, additional, Jackson, David, additional, Tsoleridis, Jessica, additional, Pesavento, Lauren, additional, Kleinig, Timothy John, additional, Nurs, Roy Drew, additional, Cranefield, Jennifer, additional, Scroop, Rebecca, additional, Cagi, Lavenia, additional, Harvey, Jackson, additional, Waters, Michael, additional, Brennan, Robert, additional, O'Hare, Alan, additional, Power, Sarah, additional, Williams, David, additional, Boyle, Karl, additional, Moynihan, Barry, additional, Liddy, Ann-Marie, additional, Large, Margaret, additional, Cullen, Ailbhe, additional, Walsh, Roisin, additional, Martin, Emma, additional, Lynch, Julie, additional, McElroy, Sinéad, additional, Coveney, Sarah, additional, Deegan, Caroline, additional, Horgan, Gillian, additional, Kelly, Peter, additional, Laffan, Aoife, additional, Llamas-Osorio, Yudy, additional, Lynch, Catherine, additional, Mac Mahon, Peter, additional, Marnane, Michael, additional, McCabe, John, additional, Burns, Paul, additional, Tauro, Suzanne, additional, Cuddy, Sarah, additional, Rennie, Ian, additional, Smyth, Graham, additional, Flynn, Peter, additional, Wiggam, Ivan, additional, Kerr, Enda, additional, Gordon, Patricia, additional, Fearon, Patricia, additional, Roberts, Geralt, additional, Patterson, Cathy, additional, Adams, Karen, additional, Wells, Brian, additional, McFarland, Margaret, additional, Moreira, Tiago, additional, Sjöstrand, Christina, additional, Mazya, Michael, additional, Almqvist, Håkan, additional, Wahlgren, Nils, additional, Steinberg, Anna, additional, Cooray, Charith, additional, Eriksson, Einar, additional, Thorén, Magnus, additional, Keselman, Boris, additional, Ahmed, NIaz, additional, Holmberg, Åke, additional, Axelsson, Maria, additional, Berglund, Annika, additional, Golsari, Amir, additional, Hoppe, Julia, additional, Deb-Chatterji, Milani, additional, Cheng, Bastian, additional, Barrow, Ewgenia, additional, Schlemm, Eckhard, additional, Lettow, Iris, additional, Jensen, Märit, additional, Otto, Dagmar, additional, Jaramillo, Kirsten, additional, Appelbohm, Hannes, additional, Fiehler, Jens, additional, Bester, Maxim, additional, Schönfeld, Michael, additional, Brekenfeld, Caspar, additional, Holst, Brigitte, additional, Wortmann, Ginette, additional, Koch, Friederike, additional, Gerber, Johannes, additional, Abramyuk, Andrij, additional, Kaiser, Daniel, additional, Winzer, Simon, additional, Prakapenia, Alexandra, additional, Pallesen, Lars-Peder, additional, Siepmann, Timo, additional, Barlinn, Kristian, additional, Haase, Kathrin, additional, Sauer, Angela, additional, Liman, Jan, additional, Brehm, Alex, additional, Maus, Volker, additional, Hollstein, Nicole, additional, Reinke, Annika, additional, Neitz, Gustav, additional, Schnieder, Marlena, additional, Schwarz, Margret, additional, Ibrahim, Allam, additional, Müller, Julia, additional, Meister, Stefanie, additional, Bäumle, Berit, additional, Pilgram-Pastor, Sara, additional, Wallocha, Marta, additional, Stauder, Michael, additional, Celik, Ekin, additional, Stracke, Paul, additional, Müller, Nicole, additional, Weber, Ralph, additional, Velktamp, Roland, additional, Ringleb, Peter Arthur, additional, Heyse, Miriam, additional, Amiri, Hemasse, additional, Mundiyanapurath, Sibu, additional, Chen, Min, additional, Bevrle, Elisabeth, additional, Beck, Perdita, additional, Möhlenbruch, Markus alfred, additional, Potvin, Alphonse, additional, Harris, Cameron, additional, Wang, Chong, additional, Adams, Corey, additional, Mayor, Diana, additional, Garman, Dave, additional, Chau, Davis, additional, Wu, Jane, additional, Lunn, Janet, additional, Bermanis, Liat, additional, Teyes, Lucy, additional, Constant, Marc, additional, Galsim, Maria, additional, Helbin, Michael, additional, Leroux, Michelle, additional, Felix, Nicole, additional, Bendre, Nilima, additional, Cuthbert, Sandra, additional, Brokx, Steve, additional, Zhang, Yichuan, additional, Lingham, Trudy, additional, Kohli, Yatika, additional, Salter, Michael, additional, Liebeschuetz, Joseph, additional, Hofmann, Frieder, additional, Constant, John, additional, Soeder, Tom, additional, Snoke, Kara, additional, Bologa, Monica, additional, Stahl, Kimberly, additional, and Graziewicz, Maria, additional

Published
2020
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7. Abstract 161: Prediction of Thrombolysis-induced Parenchymal Hemorrhage in Patients With Acute Ischemic Stroke: Use of MR Perfusion and Diffusion Biomarkers

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Nael, Kambiz, primary, Knitter, James, additional, Jahan, Reza, additional, Alger, Jeffry R, additional, Nenov, Val, additional, Ajani, Zahra, additional, Feng, Lei, additional, Meyer, Brett C, additional, Olson, Scott, additional, Schwamm, Lee H, additional, Yoo, Albert J, additional, Marshall, Randolph S, additional, Meyers, Philip M, additional, Yavagal, Dileep R, additional, Wintermark, Max, additional, Liebeskind, David S, additional, Guzy, Judy, additional, Saver, Jeffrey L, additional, and Kidwell, Chelsea S, additional

Published
2016
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