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1,843 results on '"Handal, A"'

1. Comorbidity of Obsessive-Compulsive Disorder in Youth Diagnosed with Oppositional Defiant Disorder

Author

Nelson Handal, Emma Quadlander-Goff, Laura Handal Abularach, Sarah Seghrouchni, and Barbara Baldwin

Abstract

Understanding the overlap of symptoms between oppositional defiant disorder (ODD) and obsessivecompulsive disorder (OCD) experienced by youth is pertinent for accurate diagnosis. A quantitative, retrospective, cross-sectional design format was used to assess the relationship between ODD and OCD in addition to evaluating the difference in ODD severity and symptoms based on OCD severity. Symptoms and severity ratings of ODD and OCD were collected from youth diagnosed with ODD (N = 179). Fisher's exact test and a Wilcoxon signed-rank test were performed. There were significant relationships between frustration related to obsessions and compulsions and the ODD symptoms of annoyance and anger. Results suggested that OCD severity predicted an increase in scores for ODD severity and symptoms.

Published
2024

2. KANOP: A Data-Efficient Option Pricing Model using Kolmogorov-Arnold Networks

Author

Handal, Rushikesh, Matoya, Kazuki, Wang, Yunzhuo, and Hirano, Masanori

Subjects
Quantitative Finance - Computational Finance, Computer Science - Computational Engineering, Finance, and Science, Quantitative Finance - Mathematical Finance, Quantitative Finance - Pricing of Securities
Abstract

Inspired by the recently proposed Kolmogorov-Arnold Networks (KANs), we introduce the KAN-based Option Pricing (KANOP) model to value American-style options, building on the conventional Least Square Monte Carlo (LSMC) algorithm. KANs, which are based on Kolmogorov-Arnold representation theorem, offer a data-efficient alternative to traditional Multi-Layer Perceptrons, requiring fewer hidden layers to achieve a higher level of performance. By leveraging the flexibility of KANs, KANOP provides a learnable alternative to the conventional set of basis functions used in the LSMC model, allowing the model to adapt to the pricing task and effectively estimate the expected continuation value. Using examples of standard American and Asian-American options, we demonstrate that KANOP produces more reliable option value estimates, both for single-dimensional cases and in more complex scenarios involving multiple input variables. The delta estimated by the KANOP model is also more accurate than that obtained using conventional basis functions, which is crucial for effective option hedging. Graphical illustrations further validate KANOP's ability to accurately model the expected continuation value for American-style options.

Published
2024

3. Computationally restoring the potency of a clinical antibody against Omicron.

Author

Desautels, Thomas, Arrildt, Kathryn, Zemla, Adam, Lau, Edmond, Zhu, Fangqiang, Ricci, Dante, Cronin, Stephanie, Zost, Seth, Binshtein, Elad, Scheaffer, Suzanne, Dadonaite, Bernadeta, Petersen, Brenden, Engdahl, Taylor, Chen, Elaine, Handal, Laura, Hall, Lynn, Goforth, John, Vashchenko, Denis, Nguyen, Sam, Weilhammer, Dina, Lo, Jacky, Rubinfeld, Bonnee, Saada, Edwin, Weisenberger, Tracy, Lee, Tek-Hyung, Whitener, Bradley, Case, James, Ladd, Alexander, Silva, Mary, Haluska, Rebecca, Grzesiak, Emilia, Earnhart, Christopher, Hopkins, Svetlana, Bates, Thomas, Thackray, Larissa, Segelke, Brent, Lillo, Antonietta, Sundaram, Shivshankar, Bloom, Jesse, Diamond, Michael, Crowe, James, Carnahan, Robert, and Faissol, Daniel

Subjects
Animals, Female, Humans, Mice, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Mutation, Neutralization Tests, SARS-CoV-2, Spike Glycoprotein, Coronavirus, DNA Mutational Analysis, Antigenic Drift and Shift, Drug Design, Computer Simulation
Abstract

The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs1-3 and revealed how quickly viral escape can curtail effective options4,5. When the SARS-CoV-2 Omicron variant emerged in 2021, many antibody drug products lost potency, including Evusheld and its constituent, cilgavimab4-6. Cilgavimab, like its progenitor COV2-2130, is a class 3 antibody that is compatible with other antibodies in combination4 and is challenging to replace with existing approaches. Rapidly modifying such high-value antibodies to restore efficacy against emerging variants is a compelling mitigation strategy. We sought to redesign and renew the efficacy of COV2-2130 against Omicron BA.1 and BA.1.1 strains while maintaining efficacy against the dominant Delta variant. Here we show that our computationally redesigned antibody, 2130-1-0114-112, achieves this objective, simultaneously increases neutralization potency against Delta and subsequent variants of concern, and provides protection in vivo against the strains tested: WA1/2020, BA.1.1 and BA.5. Deep mutational scanning of tens of thousands of pseudovirus variants reveals that 2130-1-0114-112 improves broad potency without increasing escape liabilities. Our results suggest that computational approaches can optimize an antibody to target multiple escape variants, while simultaneously enriching potency. Our computational approach does not require experimental iterations or pre-existing binding data, thus enabling rapid response strategies to address escape variants or lessen escape vulnerabilities.

Published
2024

7. Comparison of the biodiversity of epiphytic diatoms in the Euphrates-Tigris rivers using morphological and metabarcoding analyses

Author

Heba Mohamad, Katherina Schimani, Maitham Al-Shaheen, Nélida Abarca, Regine Jahn, Adil Al-Handal, Wolf-Henning Kusber, and Jonas Zimmermann

Subjects
Ecology, QH540-549.5
Abstract

The Euphrates-Tigris catchment area is one of the major drainage basins in the Middle East but climate change, overuse of waters and subsequent salinization has brought this region to the brink of ecological devastation. The aim of this study was to investigate the biodiversity of epiphytic diatoms in Iraq, for the first time using a combination of morphological and metabarcoding methods. 47 samples were collected at six sampling sites along the Rivers Tigris and Euphrates in northern Basra, Southern Iraq, during the summer of 2019 (dry season) and winter of 2020 (rainy season). The composition of the epiphytic diatoms in each sample was compared with both methods. The microscopic-morphological analysis of the environmental samples resulted in the identification of 284 infrageneric taxa in 59 genera. For the metabarcoding analysis the V4 region of the 18S marker gene was used and resulted in 1454 ASVs (Amplicon sequence variants) comprising 54 genera and 108 species with several ASVs belonging to the same taxa. The non-metric multidimensional scaling (NMDS) plots for morphology showed a clear seasonal effect in the diatom community composition, while the NMDS plots for 18SV4 analyses did not show a seasonal effect in community composition for the same samples. The incomplete taxonomic reference database for the studied sites turned out to be the major limitation of the molecular approach. Nevertheless, the combination of morphological and molecular methods increased the detection and identification of the diatom assemblages and laid the foundation for understanding their biodiversity in this region.

Published
2024
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11. Teacher Data Use and Student Learning: Insights from a NSW Catholic School System

Author

Rosemary Vellar, Boris Handal, Sean Kearney, and Chris Forlin

Abstract

Evidence based decision making is essential for enabling improved student learning. Teacher motivations and beliefs about the types and use of data are critical determinants of decision making. Our research explored the types of data teachers use and consider valuable when measuring improvement in student learning. Findings from 294 teachers from 44 schools in the Catholic (non-government) sector in New South Wales (NSW) Australia, found that data are used to inform the sequence of learning and to identify and address student needs. Both quantitative and qualitative data sources are applied to make claims of improvement. Factors such as ability, gender, school role, and school sector (primary or secondary) impact the selection and use of data. Our recommendations include the need to focus on professional learning to develop practising and preservice teachers' data literacy skills, ranging from statistical literacy to the identification and selection of appropriate data to substantiate claims of improvement.

Published
2024

12. Computationally restoring the potency of a clinical antibody against Omicron

Author

Desautels, Thomas A., Arrildt, Kathryn T., Zemla, Adam T., Lau, Edmond Y., Zhu, Fangqiang, Ricci, Dante, Cronin, Stephanie, Zost, Seth J., Binshtein, Elad, Scheaffer, Suzanne M., Dadonaite, Bernadeta, Petersen, Brenden K., Engdahl, Taylor B., Chen, Elaine, Handal, Laura S., Hall, Lynn, Goforth, John W., Vashchenko, Denis, Nguyen, Sam, Weilhammer, Dina R., Lo, Jacky Kai-Yin, Rubinfeld, Bonnee, Saada, Edwin A., Weisenberger, Tracy, Lee, Tek-Hyung, Whitener, Bradley, Case, James B., Ladd, Alexander, Silva, Mary S., Haluska, Rebecca M., Grzesiak, Emilia A., Earnhart, Christopher G., Hopkins, Svetlana, Bates, Thomas W., Thackray, Larissa B., Segelke, Brent W., Lillo, Antonietta Maria, Sundaram, Shivshankar, Bloom, Jesse D., Diamond, Michael S., Crowe, Jr, James E., Carnahan, Robert H., and Faissol, Daniel M.

Published
2024
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15. Navigating directed evolution efficiently: optimizing selection conditions and selection output analysis

Author

Paola Handal-Marquez, Hoai Nguyen, and Vitor B. Pinheiro

Subjects
directed evolution, design of experiments, polymerase engineering, fitness landscape, next-generation sequencing (NGS) data analysis, Biology (General), QH301-705.5
Abstract

Directed evolution is a powerful tool that can bypass gaps in our understanding of the sequence-function relationship of proteins and still isolate variants with desired activities, properties, and substrate specificities. The rise of directed evolution platforms for polymerase engineering has accelerated the isolation of xenobiotic nucleic acid (XNA) synthetases and reverse transcriptases capable of processing a wide array of unnatural XNAs which have numerous therapeutic and biotechnological applications. Still, the current generation of XNA polymerases functions with significantly lower efficiency than the natural counterparts and retains a significant level of DNA polymerase activity which limits their in vivo applications. Although directed evolution approaches are continuously being developed and implemented to improve XNA polymerase engineering, the field lacks an in-depth analysis of the effect of selection parameters, library construction biases and sampling biases. Focusing on the directed evolution pipeline for DNA and XNA polymerase engineering, this work sets out a method for understanding the impact of selection conditions on selection success and efficiency. We also explore the influence of selection conditions on fidelity at the population and individual mutant level. Additionally, we explore the sequencing coverage requirements in directed evolution experiments, which differ from genome assembly and other -omics approaches. This analysis allowed us to identify the sequencing coverage threshold for the accurate and precise identification of significantly enriched mutants. Overall, this study introduces a robust methodology for optimizing selection protocols, which effectively streamlines selection processes by employing small libraries and cost-effective NGS sequencing. It provides valuable insights into critical considerations, thereby enhancing the overall effectiveness and efficiency of directed evolution strategies applicable to enzymes other than the ones considered here.

Published
2024
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16. The relationships between perceived mental illness prevalence, mental illness stigma, and attitudes toward help-seeking

Author

Evans, Luke, Chang, Alexander, Dehon, Jewell, Streb, Madison, Bruce, Madeline, Clark, Eddie, and Handal, Paul

Subjects
Distribution, Social aspects, Research, Company distribution practices, Mental disorders -- Distribution -- Social aspects, Psychological research, Help seeking behavior -- Research, Stigma (Social psychology) -- Research, Help-seeking behavior -- Research, Mental illness -- Distribution -- Social aspects
Abstract

Author(s): Luke Evans [sup.1] [sup.2] , Alexander Chang [sup.1] , Jewell Dehon [sup.1] , Madison Streb [sup.1] , Madeline Bruce [sup.1] , Eddie Clark [sup.1] , Paul Handal [sup.1] Author [...], Previous research suggests that, despite the commonality of mental illness in the United States, the majority of U.S. individuals with mental illness do not seek treatment. One important factor that contributes to this lack of treatment utilization is mental illness stigma. Such stigma may result, in part, from many individuals in the U.S. underestimating the prevalence of mental illness. To test whether this is the case, 638 adults from across the U.S. completed measures related to perceived prevalence of mental illness, private stigma, perceived public stigma, and help-seeking. Findings indicated participants significantly underestimated the given-year prevalence rate of mental illness. The perceived given-year prevalence rate was significantly correlated with lower private stigma and more positive attitudes towards help-seeking. Personal stigma significantly predicted attitudes towards help-seeking. Findings also suggested that individuals who have received mental health services have a higher perceived prevalence rate of mental illness, as well as lower levels of personal stigma and more positive attitudes towards help-seeking. These findings support the notion that helping the general public recognize the true prevalence rate of mental illness could reduce personal mental illness stigma and facilitate help-seeking behaviors. However, future experimental studies are needed to test this hypothesis.

Published
2024
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17. Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Author

Arndt, Michael Benjamin, Abate, Yohannes Habtegiorgis, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdulah, Deldar Morad, Abdulkader, Rizwan Suliankatchi, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abtew, Yonas Derso, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Acuna, Juan Manuel, Adamu, Kidist, Adane, Denberu Eshetie, Addo, Isaac Yeboah, Adeyinka, Daniel Adedayo, Adnani, Qorinah Estiningtyas Sakilah, Afolabi, Aanuoluwapo Adeyimika, Afrashteh, Fatemeh, Afzal, Saira, Agodi, Antonella, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmed, Ali, Ahmed, Luai A A, Ajami, Marjan, Aji, Budi, Akbarialiabad, Hossein, Akonde, Maxwell, Al Hamad, Hanadi, Al Thaher, Yazan, Al-Aly, Ziyad, Alhabib, Khalid F, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Syed Shujait, Alimohamadi, Yousef, Aljunid, Syed Mohamed, Al-Mekhlafi, Hesham M, Almustanyir, Sami, Alomari, Mahmoud A, Al-Tammemi, Alaa B, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amiri, Sohrab, Amu, Hubert, Amugsi, Dickson A, Anagaw, Tadele Fentabel Fentabil, Ancuceanu, Robert, Angappan, Dhanalakshmi, Ansari-Moghaddam, Alireza, Antriyandarti, Ernoiz, Anvari, Davood, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Aravkin, Aleksandr Y, Ariffin, Hany, Aripov, Timur, Arkew, Mesay, Armocida, Benedetta, Arumugam, Ashokan, Aryastami, Ni Ketut, Asaad, Malke, Asemi, Zatollah, Asemu, Mulu Tiruneh, Asghari-Jafarabadi, Mohammad, Astell-Burt, Thomas, Athari, Seyyed Shamsadin, Atomsa, Gamechu Hunde, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Aujayeb, Avinash, Awoke, Mamaru Ayenew, Azadnajafabad, Sina, Azevedo, Rui M S, B, Darshan B, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nasser, Bagherieh, Sara, Baig, Atif Amin, Baker, Jennifer L, Balasubramanian, Madhan, Baltatu, Ovidiu Constantin, Banach, Maciej, Banik, Palash Chandra, Barchitta, Martina, Bärnighausen, Till Winfried, Barr, Ronald D, Barrow, Amadou, Barua, Lingkan, Bashiri, Azadeh, Baskaran, Pritish, Basu, Saurav, Bekele, Alehegn, Belay, Sefealem Assefa, Belgaumi, Uzma Iqbal, Bell, Shelly L, Belo, Luis, Bennett, Derrick A, Bensenor, Isabela M, Beressa, Girma, Bermudez, Amiel Nazer C, Beyene, Habtamu B, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattacharjee, Natalia V, Bhutta, Zulfiqar A, Bitaraf, Saeid, Bodolica, Virginia, Bonakdar Hashemi, Milad, Braithwaite, Dejana, Butt, Muhammad Hammad, Butt, Zahid A, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Cao, Chao, Cárdenas, Rosario, Carvalho, Márcia, Castañeda-Orjuela, Carlos A, Catapano, Alberico L, Cattaruzza, Maria Sofia, Cembranel, Francieli, Cerin, Ester, Chadwick, Joshua, Chalek, Julian, Chandrasekar, Eeshwar K, Charan, Jaykaran, Chattu, Vijay Kumar, Chauhan, Kirti, Chien, Ju-Huei, Chitheer, Abdulaal, Choudhari, Sonali Gajanan, Chowdhury, Enayet Karim, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Sheng-Chia, Claro, Rafael M, Columbus, Alyssa, Cortese, Samuele, Cruz-Martins, Natalia, Dabo, Bashir, Dadras, Omid, Dai, Xiaochen, D'Amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Darban, Isaac, Darmstadt, Gary L, Darwesh, Aso Mohammad, Darwish, Amira Hamed, Das, Jai K, Das, Saswati, Davletov, Kairat, De la Hoz, Fernando Pio, Debele, Aklilu Tamire, Demeke, Dessalegn, Demissie, Solomon, Denova-Gutiérrez, Edgar, Desai, Hardik Dineshbhai, Desta, Abebaw Alemayehu, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dias da Silva, Diana, Diaz, Daniel, Diress, Mengistie, Djalalinia, Shirin, Doaei, Saeid, Dongarwar, Deepa, Dsouza, Haneil Larson, Edalati, Sareh, Edinur, Hisham Atan, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Elbarazi, Iffat, Elgendy, Islam Y, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, Eshetu, Habitu Birhan, Espinosa-Montero, Juan, Esubalew, Habtamu, Etaee, Farshid, Etafa, Werku, Fagbamigbe, Adeniyi Francis, Fakhradiyev, Ildar Ravisovich, Falzone, Luca, Farinha, Carla Sofia e Sá, Farmer, Sam, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Feigin, Valery L, Feizkhah, Alireza, Feng, Xiaoqi, Ferrara, Pietro, Fetensa, Getahun, Fischer, Florian, Fitzgerald, Ryan, Flood, David, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fowobaje, Kayode Raphael, Franklin, Richard Charles, Fukumoto, Takeshi, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gakidou, Emmanuela, Galali, Yaseen, Galehdar, Nasrin, Gardner, William M, Garg, Priyanka, Gebremeskel, Teferi Gebru, Gerema, Urge, Getacher, Lemma, Getachew, Motuma Erena, Getawa, Solomon, Ghaffari, Kazem, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghassemi, Fariba, Ghith, Nermin, Gholamalizadeh, Maryam, Gholami, Ali, Gholamrezanezhad, Ali, Ghozy, Sherief, Gill, Paramjit Singh, Gill, Tiffany K, Glasbey, James C, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Goudarzi, Houman, Grivna, Michal, Guadie, Habtamu Alganeh, Gubari, Mohammed Ibrahim Mohialdeen, Gudayu, Temesgen Worku, Guha, Avirup, Gunawardane, Damitha Asanga, Gupta, Anish Kumar, Gupta, Bhawna, Gupta, Rahul, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Hagins, Hailey, Haj-Mirzaian, Arvin, Handal, Alexis J, Hanif, Asif, Hankey, Graeme J, Harapan, Harapan, Hargono, Arief, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hasani, Hamidreza, Hashi, Abdiwahab, Hassanipour, Soheil, Havmoeller, Rasmus J, Hay, Simon I, Hayat, Khezar, He, Jiawei, Heidari-Foroozan, Mahsa, Herteliu, Claudiu, Hessami, Kamran, Heyi, Demisu Zenbaba, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hoogar, Praveen, Hossain, Sheikh Jamal, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hoveidamanesh, Soodabeh, Huang, Junjie, Humphrey, Kyle Matthew, Hussain, Salman, Hussien, Foziya Mohammed, Hwang, Bing-Fang, Iacoviello, Licia, Iftikhar, Pulwasha Maria, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Inbaraj, Leeberk Raja, Iravanpour, Farideh, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie Declan, J, Linda Merin, Jacob, Louis, Jahrami, Haitham, Jakovljevic, Mihajlo, Jamshidi, Elham, Janodia, Manthan Dilipkumar, Jayanna, Krishnamurthy, Jayapal, Sathish Kumar, Jayaram, Shubha, Jebai, Rime, Jema, Alelign Tasew, Jeswani, Bijay Mukesh, Jonas, Jost B, Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kamal, Vineet Kumar, Kamble, Bhushan Dattatray, Kandel, Himal, Kapoor, Neeti, Karaye, Ibraheem M, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Harkiran, Kayode, Gbenga A, Kebede, Worku Misganaw, Kebira, Jemal Yusuf, Keflie, Tibebeselassie S, Kerr, Jessica A, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khalid, Nauman, Khammarnia, Mohammad, Khan, M Nuruzzaman, Khan, Moien AB, Khan, Taimoor, Khan, Yusra H, Khanali, Javad, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khatib, Mahalaqua Nazli, Khayat Kashani, Hamid Reza, Khubchandani, Jagdish, Kifle, Zemene Demelash, Kim, Gyu Ri, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kompani, Farzad, Kondlahalli, Shivakumar KM Marulasiddaiah, Koohestani, Hamid Reza, Korzh, Oleksii, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kuddus, Mohammed, Kumar, G Anil, Kumar, Manasi, Kumar, Nithin, Kurmanova, Almagul, Kurmi, Om P, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Larsson, Anders O, Latief, Kamaluddin, Ledda, Caterina, Lee, Paul H, Lee, Sang-woong, Lee, Wei-Chen, Lee, Yo Han, Lenzi, Jacopo, Li, Ming-Chieh, Li, Wei, Ligade, Virendra S, Lim, Stephen S, Lindstedt, Paulina A, Lo, Chun-Han, Lo, Justin, Lodha, Rakesh, Loreche, Arianna Maever, Lorenzovici, László, Lorkowski, Stefan, Madadizadeh, Farzan, Madureira-Carvalho, Áurea M, Mahajan, Preetam Bhalchandra, Makris, Konstantinos Christos, Malakan Rad, Elaheh, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Manguerra, Helena, Marjani, Abdoljalal, Martini, Santi, Martorell, Miquel, Masrie, Awoke, Mathews, Elezebeth, Maugeri, Andrea, Mazaheri, Maryam, Mediratta, Rishi P, Mehndiratta, Man Mohan, Melaku, Yohannes Adama, Mendoza, Walter, Menezes, Ritesh G, Mensah, George A, Mentis, Alexios-Fotios A, Meretoja, Tuomo J, Mestrovic, Tomislav, Miazgowski, Tomasz, Miller, Ted R, Mini, GK, Mirghafourvand, Mojgan, Mirica, Andreea, Mirrakhimov, Erkin M, Mirza, Moonis, Misra, Sanjeev, Mithra, Prasanna, Mohammad, Karzan Abdulmuhsin, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Mohseni, Mohammad, Mokdad, Ali H, Monasta, Lorenzo, Moni, Mohammad Ali, Moradi, Maryam, Moradi, Yousef, Morrison, Shane Douglas, Mougin, Vincent, Mubarik, Sumaira, Mueller, Ulrich Otto, Mulita, Francesk, Munblit, Daniel, Murillo-Zamora, Efren, Murray, Christopher J L, Mustafa, Ghulam, Nagarajan, Ahamarshan Jayaraman, Nangia, Vinay, Narasimha Swamy, Sreenivas, Natto, Zuhair S, Naveed, Muhammad, Nayak, Biswa Prakash, Nejadghaderi, Seyed Aria, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Nguyen, Phuong The, Nguyen, QuynhAnh P, Niazi, Robina Khan, Nnaji, Chukwudi A, Noor, Nurulamin M, Noubiap, Jean Jacques, Nri-Ezedi, Chisom Adaobi, Nurrika, Dieta, Nwatah, Vincent Ebuka, Oancea, Bogdan, Obamiro, Kehinde O, Oghenetega, Onome Bright, Ogunsakin, Ropo Ebenezer, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okello, Daniel Micheal, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olana, Diriba Dereje, Oliveira, Gláucia Maria Moraes, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Sok King, Ortega-Altamirano, Doris V, Ortiz, Alberto, Ostojic, Sergej M, Otoiu, Adrian, Oumer, Abdu, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pana, Adrian, Panda-Jonas, Songhomitra, Pandey, Anamika, Pandi-Perumal, Seithikurippu R, Papadopoulou, Paraskevi, Pardhan, Shahina, Pasovic, Maja, Patel, Jay, Pathan, Aslam Ramjan, Paudel, Deepak, Pawar, Shrikant, Pepito, Veincent Christian Filipino, Pereira, Gavin, Pereira, Marcos, Perico, Norberto, Perna, Simone, Petcu, Ionela-Roxana, Petermann-Rocha, Fanny Emily, Piracha, Zahra Zahid, Plakkal, Nishad, Pourtaheri, Naeimeh, Radfar, Amir, Radhakrishnan, Venkatraman, Raggi, Catalina, Raghav, Pankaja, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Azizur, Rahman, Md Mosfequr, Rahman, Md Obaidur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmanian, Vahid, Rahmawaty, Setyaningrum, Rai, Rajesh Kumar, Raimondo, Ivano, Rajaa, Sathish, Rajput, Prashant, Ram, Pradhum, Ramasamy, Shakthi Kumaran, Ramazanu, Sheena, Rao, Chythra R, Rao, Indu Ramachandra, Rao, Sowmya J, Rasali, Drona Prakash, Rashid, Ahmed Mustafa, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, Salman, Rawal, Lal, Redwan, Elrashdy M Moustafa Mohamed, Remuzzi, Giuseppe, Rengasamy, Kannan RR, Renzaho, Andre M N, Rezaee, Malihe, Rezaei, Nazila, Rezaeian, Mohsen, Riad, Abanoub, Rickard, Jennifer, Rodriguez, Alina, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Rohloff, Peter, Roy, Bedanta, Rwegerera, Godfrey M, S N, Chandan, Saad, Aly M A, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sachdeva Dhingra, Mamta, Saddik, Basema Ahmad, Sadeghi, Erfan, Sadeghi, Malihe, Sadeghian, Saeid, Saeed, Umar, Saeedi Moghaddam, Sahar, Safi, Sher Zaman, Saheb Sharif-Askari, Fatemeh, Sahebkar, Amirhossein, Sahoo, Harihar, Sahoo, Soumya Swaroop, Sajid, Mirza Rizwan, Salem, Marwa Rashad, Samy, Abdallah M, Sanabria, Juan, Sanjeev, Rama Krishna, Sankararaman, Senthilkumar, Santos, Itamar S, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sargazi, Saman, Sarikhani, Yaser, Satpathy, Maheswar, Sawhney, Monika, Saya, Ganesh Kumar, Sayeed, Abu, Scarmeas, Nikolaos, Schlaich, Markus P, Schneider, Rachel D, Schutte, Aletta Elisabeth, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Seylani, Allen, Shafie, Mahan, Shah, Pritik A, Shahbandi, Ataollah, Shaikh, Masood Ali, Shama, Adisu Tafari T, Shams-Beyranvand, Mehran, Shanawaz, Mohd, Sharew, Mequannent Melaku, Shetty, Pavanchand H, Shiri, Rahman, Shivarov, Velizar, Shorofi, Seyed Afshin, Shuval, Kerem, Sibhat, Migbar Mekonnen, Silva, Luís Manuel Lopes Rodrigues, Singh, Jasvinder A, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Skryabina, Anna Aleksandrovna, Smith, Amanda E, Solomon, Yonatan, Song, Yi, Sorensen, Reed J D, Stanaway, Jeffrey D, Sufiyan, Mu'awiyyah Babale, Suleman, Muhammad, Sun, Jing, Sunuwar, Dev Ram, Szeto, Mindy D, Tabarés-Seisdedos, Rafael, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Taheri Soodejani, Moslem, Tamuzi, Jacques Lukenze JL, Tan, Ker-Kan, Tarigan, Ingan Ukur, Tariku, Zerihun, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tat, Nathan Y, Taye, Birhan Tsegaw, Taylor, Heather Jean, Tefera, Yibekal Manaye, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Teramoto, Masayuki, Thangaraju, Pugazhenthan, Thapar, Rekha, Thiyagarajan, Arulmani, Thrift, Amanda G, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Tonelli, Marcello, Topor-Madry, Roman, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Ullah, Sana, Undurraga, Eduardo A, Unnikrishnan, Bhaskaran, Ushula, Tolassa Wakayo, Vahabi, Seyed Mohammad, Vakilian, Alireza, Valadan Tahbaz, Sahel, Valizadeh, Rohollah, Van den Eynde, Jef, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Verma, Madhur, Veroux, Massimiliano, Vervoort, Dominique, Vlassov, Vasily, Vollset, Stein Emil, Vukovic, Rade, Waheed, Yasir, Wang, Cong, Wang, Fang, Wassie, Molla Mesele, Weerakoon, Kosala Gayan, Wei, Melissa Y, Werdecker, Andrea, Wickramasinghe, Nuwan Darshana, Wolde, Asrat Arja, Wubetie, Gedif Ashebir, Wulandari, Ratna Dwi, Xu, Rongbin, Xu, Suowen, Xu, Xiaoyue, Yadav, Lalit, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yaya, Sanni, Yazdanpanah, Fereshteh, Yehualashet, Sisay Shewasinad, Yiğit, Arzu, Yiğit, Vahit, Yon, Dong Keon, Yu, Chuanhua, Yuan, Chun-Wei, Zamagni, Giulia, Zaman, Sojib Bin, Zanghì, Aurora, Zangiabadian, Moein, Zare, Iman, Zastrozhin, Michael, Zigler, Bethany, Zoladl, Mohammad, Zou, Zhiyong, Kassebaum, Nicholas J, and Reiner, Robert C, Jr

Published
2024
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19. The Use of Physics Pocketbook Based on Augmented Reality on Planetary Motion to Improve Students' Learning Achievement

Author

Suprapto, Nadi, Ibisono, Handal Setyo, and Mubarok, Husni

Abstract

Planetary motion in physics learning is an abstract concept and requires high reasoning. This article is one of the augmented realities (AR)-based pocketbook development on the planetary motion, focusing on student learning achievement. The study used the ADDIE model : "Analysis-Design-Development-Implementation-Evaluation". In the Spring Semester 2020, researchers took these steps in producing an AR-based pocketbook on planetary motion materials. The trial carried out on 30 students (57% girls and 43% boys, with age 16-17) at a public high school in Surabaya, Indonesia. Evaluation parameters included the quality of the AR-based pocketbook, students' learning achievement, and research outputs. Data analysis techniques used descriptive statistics, N-gain score, and independent t-test. The results showed that: (1) the process of developing an AR-based pocketbook on planetary motion fulfilled the product quality criteria: validity, practicality, and effectiveness; (2) students' learning achievement increase as seen from the results of the pretest-posttest scores with the average Gain score was 0.63 in the moderate category in which the boys perform better than the girls; (3) through the development of an AR-based pocketbook, it resulted in some articles in journals and pocketbook media based on Augmented reality. Therefore, this study's recommendation is to use AR as a media for learning in other abstract physics concepts.

Published
2021

20. Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.

Author

Zúñiga-Venegas, Liliana, Hyland, Carly, Muñoz-Quezada, María, Quirós-Alcalá, Lesliam, Butinof, Mariana, Buralli, Rafael, Cardenas, Andres, Fernandez, Ricardo, Foerster, Claudia, Gouveia, Nelson, Gutiérrez Jara, Juan, Lucero, Boris, Muñoz, María, Ramírez-Santana, Muriel, Smith, Anna, Tirado, Noemi, van Wendel de Joode, Berna, Calaf, Gloria, Handal, Alexis, Soares da Silva, Agnes, Cortés, Sandra, and Mora, Ana

Subjects
Agriculture, Carbamates, Caribbean Region, Child, Environmental Exposure, Female, Humans, Latin America, Occupational Exposure, Organophosphates, Pesticides, Placenta, Pregnancy
Abstract

BACKGROUND: Multiple epidemiological studies have shown that exposure to pesticides is associated with adverse health outcomes. However, the literature on pesticide-related health effects in the Latin American and the Caribbean (LAC) region, an area of intensive agricultural and residential pesticide use, is sparse. We conducted a scoping review to describe the current state of research on the health effects of pesticide exposure in LAC populations with the goal of identifying knowledge gaps and research capacity building needs. METHODS: We searched PubMed and SciELO for epidemiological studies on pesticide exposure and human health in LAC populations published between January 2007 and December 2021. We identified 233 publications from 16 countries that met our inclusion criteria and grouped them by health outcome (genotoxicity, neurobehavioral outcomes, placental outcomes and teratogenicity, cancer, thyroid function, reproductive outcomes, birth outcomes and child growth, and others). RESULTS: Most published studies were conducted in Brazil (37%, n=88) and Mexico (20%, n=46), were cross-sectional in design (72%, n=167), and focused on farmworkers (45%, n=105) or children (21%, n=48). The most frequently studied health effects included genotoxicity (24%, n=62) and neurobehavioral outcomes (21%, n=54), and organophosphate (OP) pesticides were the most frequently examined (26%, n=81). Forty-seven percent (n=112) of the studies relied only on indirect pesticide exposure assessment methods. Exposure to OP pesticides, carbamates, or to multiple pesticide classes was consistently associated with markers of genotoxicity and adverse neurobehavioral outcomes, particularly among children and farmworkers. DISCUSSION: Our scoping review provides some evidence that exposure to pesticides may adversely impact the health of LAC populations, but methodological limitations and inconsistencies undermine the strength of the conclusions. It is critical to increase capacity building, integrate research initiatives, and conduct more rigorous epidemiological studies in the region to address these limitations, better inform public health surveillance systems, and maximize the impact of research on public policies. https://doi.org/10.1289/EHP9934.

Published
2022

21. Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990–2021: findings from the Global Burden of Disease Study 2021

Author

Comfort, Haley, McHugh, Theresa A, Schumacher, Austin E, Harris, Ashley, May, Erin A, Paulson, Katherine R, Gardner, William M, Fuller, John E, Frisch, Meghan E, Taylor, Heather Jean, Leever, Andrew T, Teply, Corey, Verghese, Nicholas Alexander, Alam, Tahiya, Abate, Yohannes Habtegiorgis, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdissa, Daba, Abdoun, Meriem, Abdulkader, Rizwan Suliankatchi, Abebe, Mesfin, Abedi, Aidin, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abrigo, Michael R M, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Adane, Mesafint Molla, Addo, Isaac Yeboah, Adema, Bulcha Guye, Adesina, Miracle Ayomikun, Adetunji, Charles Oluwaseun Oluwaseun, Adeyinka, Daniel Adedayo, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Agampodi, Suneth Buddhika, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmadi, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ajami, Marjan, Akinosoglou, Karolina, Al Hasan, Syed Mahfuz, Al-Aly, Ziyad, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albashtawy, Mohammed, Alemi, Sharifullah, Algammal, Abdelazeem M, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Liaqat, Ali, Mohammed Usman, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Louay, Almustanyir, Sami, Altirkawi, Khalid A, Aly, Hany, Aly, Safwat, Amani, Reza, Ameyaw, Edward Kwabena, Amhare, Abebe Feyissa, Amin, Tarek Tawfik, Amiri, Sohrab, Andrei, Catalina Liliana, Andrei, Tudorel, Anoushiravani, Amir, Ansar, Adnan, Anvari, Davood, Anwer, Razique, Appiah, Francis, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Areda, Demelash, Aregawi, Brhane Berhe, Artamonov, Anton A, Aryal, Umesh Raj, Asemi, Zatollah, Asemu, Mulu Tiruneh, Asgedom, Akeza Awealom, Ashraf, Tahira, Asresie, Melash Belachew, Atlaw, Daniel, Atout, Maha Moh'd Wahbi, Atreya, Alok, Atteraya, Madhu Sudhan, Aujayeb, Avinash, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azevedo, Rui M S, Azzam, Ahmed Y, B, Darshan B, Babaei, Mahsa, Badar, Muhammad, Badiye, Ashish D, Baghcheghi, Nayereh, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bahrami Asl, Farshad, Bai, Ruhai, Bakshi, Ravleen Kaur, Bam, Kiran, Banach, Maciej, Banke-Thomas, Aduragbemi, Bansal, Hansi, Bantie, Berihun Bantie, Barchitta, Martina, Bardhan, Mainak, Bashiri, Azadeh, Basiru, Afisu, Baskaran, Pritish, Batra, Kavita, Bayani, Mojtaba, Bayleyegn, Nebiyou Simegnew, Bedi, Neeraj, Begum, Tahmina, Behnoush, Amir Hossein, Belgaumi, Uzma Iqbal, Bermudez, Amiel Nazer C, Beyene, Kebede A, Bhandari, Bharti Bhandari, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattarai, Suraj, Bodolica, Virginia, Braithwaite, Dejana, Brenner, Hermann, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Cadri, Abdul, Campos-Nonato, Ismael, Cattaruzza, Maria Sofia, Cembranel, Francieli, Cerin, Ester, Chacón-Uscamaita, Pamela Roxana, Charan, Jaykaran, Chattu, Vijay Kumar, Chauhan, Dhun, Chavula, Malizgani Paul, Chen, Simiao, Chi, Gerald, Chitheer, Abdulaal, Cho, William C S, Choudhari, Sonali Gajanan, Chu, Dinh-Toi, Cruz-Martins, Natalia, Dadras, Omid, Dagnew, Gizachew Worku, Dalaba, Maxwell Ayindenaba, Dandona, Lalit, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, Dash, Nihar Ranjan, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, Debela, Berhanu Gidisa, Debele, Aklilu Tamire, Derese, Msganaw, Deribe, Kebede, Dervišević, Emina, Dessie, Anteneh Mengist, Dhali, Arkadeep, Dhulipala, Vishal R, Dirac, M Ashworth, Dong, Wanyue, Dora, Bezabih Terefe, Dsouza, Haneil Larson, Duraes, Andre Rodrigues, Dutta, Sulagna, Dziedzic, Arkadiusz Marian, Ed-Dra, Abdelaziz, Edvardsson, Kristina, Eini, Ebrahim, Ekholuenetale, Michael, El Sayed Zaki, Maysaa, Elgendy, Islam Y, Elhadi, Muhammed, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Engelbert Bain, Luchuo, Esayas, Hawi Leul, Eshrati, Babak, Esposito, Francesco, Fagbamigbe, Adeniyi Francis, Fakhradiyev, Ildar Ravisovich, Faramarzi, Ali, Faro, Andre, Fatehizadeh, Ali, Fekadu, Ginenus, Fischer, Florian, Fomenkov, Artem Alekseevich, Fukumoto, Takeshi, Gaal, Peter Andras, Gaidhane, Abhay Motiramji, Gajdács, Márió, Galali, Yaseen, Gallus, Silvano, Ganesan, Balasankar, Gazzelloni, Federica, Gebrehiwot, Mesfin, Gebremedhin, Amanuel Tesfay, Gebremeskel, Teferi Gebru, Geda, Yohannes Fikadu, Gezae, Kebede Embaye, Ghazy, Ramy Mohamed, Gheno, Gloria, Gialluisi, Alessandro, Gissler, Mika, Glasbey, James C, Glasstetter, Logan M, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Grivna, Michal, Guha, Avirup, Guicciardi, Stefano, Guo, Hanbing, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haller, Sebastian, Halwani, Rabih, Hamidi, Samer, Handal, Alexis J, Haro, Josep Maria, Hartman, Nicholas Nathaniel, Hasan, Taufiq, Hasanpour- Dehkordi, Ali, Hasnain, Md Saquib, Hassanipour, Soheil, He, Wen-Qiang, Heidari, Mohammad, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hessami, Kamran, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hossain, Md Mahbub, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hu, Chengxi, Huang, Junjie, Huda, M Mamun, Huda, Md Nazmul, Huynh, Hong-Han, Hwang, Bing-Fang, Iftikhar, Pulwasha Maria, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Iranmehr, Arad, Iravanpour, Farideh, Iwagami, Masao, Iwu, Chidozie Declan, Iyasu, Assefa N, Jaafari, Jalil, Jafarzadeh, Abdollah, Jahrami, Haitham, Janodia, Manthan Dilipkumar, Javadi, Nilofer, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jema, Alelign Tasew, Jokar, Mohammad, Joseph, Nitin, Joshua, Charity Ehimwenma, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Karaye, Ibraheem M, Karimi, Hanie, Kasraei, Hengameh, Kauppila, Joonas H, Kendal, Evie Shoshannah, Keykhaei, Mohammad, Khalid, Nauman, Khamesipour, Faham, Khan, M Nuruzzaman, Khan, Maseer, Khan, Yusra H, Khatab, Khaled, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khayat Kashani, Hamid Reza, Khormali, Moein, Kim, Min Seo, Kim, Thanh V, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kochhar, Sonali, Kolahi, Ali-Asghar, Kompani, Farzad, Koohestani, Hamid Reza, Kosen, Soewarta, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kuchay, Raja Amir Hassan, Kuddus, Mohammed, Kumar, G Anil, Kurmi, Om P, La Vecchia, Carlo, Lacey, Ben, Lahariya, Chandrakant, Laksono, Tri, Lal, Dharmesh Kumar, Lasrado, Savita, Latief, Kamaluddin, Latifinaibin, Kaveh, Le, Thao Thi Thu, Lee, Munjae, Lee, Sang-woong, Lee, Wei-Chen, Lee, Yo Han, Lenzi, Jacopo, Li, Ming-Chieh, Li, Shanshan, Ligade, Virendra S, Lim, Stephen S, Liu, Gang, Liu, Jue, Liu, Xuefeng, Lorenzovici, László, Lotfizadeh, Masoud, M Afifi, Ahmed, Madureira-Carvalho, Áurea M, Magee, Laura A, Majeed, Azeem, Malakan Rad, Elaheh, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Maravilla, Joemer C, Martini, Santi, Martins-Melo, Francisco Rogerlândio Rogerlândio, Martorell, Miquel, Marzan, Melvin Barrientos, Mathangasinghe, Yasith, Mattiello, Rita, Maugeri, Andrea, Mayeli, Mahsa, Mazaheri, Maryam, Mediratta, Rishi P, Mehrabani-Zeinabad, Kamran, Meles, Gebrekiros Gebremichael, Meles, Hadush Negash, Mendez-Lopez, Max Alberto, Mendoza, Walter, Menezes, Ritesh G, Meretoja, Atte, Meretoja, Tuomo J, Michalek, Irmina Maria, Minh, Le Huu Nhat, Mirfakhraie, Reza, Mirghafourvand, Mojgan, Mirica, Andreea, Mirrakhimov, Erkin M, Mirza, Moonis, Mishio Bawa, Eric, Misra, Sanjeev, Mizana, Biru Abdissa, Mohamed, Nouh Saad, Mohammad-Alizadeh-Charandabi, Sakineh, Mohammed, Ghada, Mohammed, Salahuddin, Mohammed, Shafiu, Mokdad, Ali H, Molinaro, Sabrina, Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moodi Ghalibaf, AmirAli, Moraga, Paula, Morovatdar, Negar, Mosapour, Abbas, Mouodi, Simin, Mousavi, Parsa, Mueller, Ulrich Otto, Mughal, Faraz, Mulita, Admir, Mulita, Francesk, Muriithi, Moses K, Nair, Tapas Sadasivan, Najmuldeen, Hastyar Hama Rashid, Nambi, Gopal, Nangia, Vinay, Nascimento, Gustavo G, Nauman, Javaid, Nejadghaderi, Seyed Aria, Nematollahi, Mohammad Hadi, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Nguyen, Dang H, Nguyen, Hau Thi Hien, Nguyen, Hien Quang, Nguyen, Phat Tuan, Niazi, Robina Khan, Nikoobar, Ali, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Noreen, Mamoona, Nurrika, Dieta, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obamiro, Kehinde O, Ogunsakin, Ropo Ebenezer, Okeke, Sylvester Reuben, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Olatubi, Matthew Idowu, Olufadewa, Isaac Iyinoluwa, Olusanya, Bolajoko Olubukunola, Ordak, Michal, Ortega-Altamirano, Doris V, Osman, Wael M S, Osuagwu, Uchechukwu Levi, Otoiu, Adrian, Otstavnov, Nikita, Otstavnov, Stanislav S, Ouyahia, Amel, Owolabi, Mayowa O, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pana, Adrian, Parija, Pragyan Paramita, Parikh, Romil R, Pashaei, Ava, Patel, Sangram Kishor, Patil, Shankargouda, Pawar, Shrikant, Pedersini, Paolo, Pepito, Veincent Christian Filipino, Peprah, Prince, Pereira, Gavin, Pereira, Jeevan, Pereira, Marcos, Pereira, Maria Odete, Perianayagam, Arokiasamy, Perico, Norberto, Pesudovs, Konrad, Petcu, Ionela-Roxana, Petermann-Rocha, Fanny Emily, Pezeshki, Parmida Sadat, Pham, Tom, Phan, My Kieu, Philip, Anil K, Pigeolet, Manon, Piracha, Zahra Zahid, Podder, Vivek, Poddighe, Dimitri, Pradhan, Pranil Man Singh, Raeisi Shahraki, Hadi, Raghav, Pankaja, Rahman, Mosiur, Rahmanian, Vahid, Raimondo, Ivano, Ramasamy, Shakthi Kumaran, Ranabhat, Chhabi Lal, Rancic, Nemanja, Rao, Chythra R, Rao, Sowmya J, Rasella, Davide, Rashid, Ahmed Mustafa, Rawassizadeh, Reza, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Rengasamy, Kannan RR, Renzaho, Andre M N, Rezaei, Nazila, Rezaei, Negar, Rezaeian, 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2024
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23. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

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Bhattacharjee, Natalia V, Schumacher, Austin E, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abiodun, Olumide, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abrigo, Michael R M, Abtahi, Dariush, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Adal, Tadele Girum Girum, Adane, Mesafint Molla, Adeagbo, Oluwafemi Atanda Adeagbo, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adepoju, Abiola Victor, Adetokunboh, Olatunji O, Adetunji, Juliana Bunmi, Adeyinka, Daniel Adedayo, Adeyomoye, Olorunsola Israel, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afolabi, Rotimi Felix, Afyouni, Shadi, Afzal, Muhammad Sohail, Afzal, Saira, Aghamiri, Shahin, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Tauseef, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Meqdad Saleh, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Akalu, Gizachew Taddesse, Akbarialiabad, Hossein, Akinyemi, Rufus Olusola, Akkaif, Mohammed Ahmed, Akkala, Sreelatha, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Al Qadire, Mohammad, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, Albashtawy, Mohammed, AlBataineh, Mohammad T, Alemi, Hediyeh, Alemi, Sharifullah, Alemu, Yihun Mulugeta, Al-Eyadhy, Ayman, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhajri, Noora, Alhalaiqa, Fadwa Alhalaiqa Naji, Alhassan, Robert Kaba, Ali, Abid, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Alif, Sheikh Mohammad, Aligol, Mohammad, Alijanzadeh, Mehran, Aljasir, Mohammad A M, Aljunid, Syed Mohamed, Al-Marwani, Sabah, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Omar, Alomari, Mahmoud A, Al-Omari, Basem, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Raddadi, Rajaa M, Al-Sabah, Salman Khalifah, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvi, Farrukh Jawad, Alvis-Guzman, Nelson, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amini-Rarani, Mostafa, Amiri, Sohrab, Ampomah, Irene Gyamfuah, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Anil, Abhishek, Anil, Sneha, Ansar, Adnan, Ansari-Moghaddam, Alireza, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Saeid, ANWAR, 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Omar Abdelsadek Abdou, Elmonem, Mohamed A, Elshaer, Mohammed, Elsohaby, Ibrahim, Emami Zeydi, Amir, Engelbert Bain, Luchuo, Eskandarieh, Sharareh, Esposito, Francesco, Estep, Kara, Etaee, Farshid, Fabin, Natalia, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Fakhri-Demeshghieh, Aliasghar, Falzone, Luca, Faramarzi, Ali, Faris, MoezAlIslam Ezzat Mahmoud, Farmer, Sam, Faro, Andre, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrara, Pietro, Ferreira, Nuno, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Flavel, Joanne, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Behzad, Foschi, Matteo, Fowobaje, Kayode Raphael, Francis, Kate Louise, Freitas, Alberto, Fukumoto, Takeshi, Fuller, John E, Fux, Blima, Gaal, Peter Andras, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Galali, Yaseen, Gallus, Silvano, Gandhi, Aravind P, Ganesan, Balasankar, 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Lindstedt, Paulina A, Listl, Stefan, Liu, Gang, Liu, Jue, Liu, Xiaofeng, Liu, Xuefeng, Liu, Yuewei, Llanaj, Erand, López-Bueno, Rubén, Lopukhov, Platon D, Lorenzovici, László, Lotufo, Paulo A, Lubinda, Jailos, Lucchetti, Giancarlo, Lugo, Alessandra, Lunevicius, Raimundas, Lv, Hengliang, Ma, Zheng Feei, Maass, Kelsey Lynn, Machoy, Monika, Madureira-Carvalho, Áurea M, Magdy Abd El Razek, Mohammed, Maghazachi, Azzam A, Mahjoub, Soleiman, Mahmoud, Mansour Adam, Majeed, Azeem, Malagón-Rojas, Jeadran N, Malakan Rad, Elaheh, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Malta, Deborah Carvalho, Mamun, Abdullah A, Manla, Yosef, Mansoori, Yasaman, Mansour, Ali, Mansouri, Borhan, Mansouri, Zeinab, Mansournia, Mohammad Ali, Maravilla, Joemer C, Marino, Mirko, Marjani, Abdoljalal, Martinez, Gabriel, Martinez-Piedra, Ramon, Martins-Melo, Francisco Rogerlândio, Martorell, Miquel, Maryam, Sharmeen, Marzo, Roy Rillera, Masoudi, Alireza, Mattumpuram, Jishanth, Maude, Richard James, Maugeri, Andrea, May, Erin A, Mayeli, Mahsa, Mazaheri, Maryam, McGrath, John J, McKee, Martin, McKowen, Anna Laura Wensel, McLaughlin, Susan A, McPhail, Steven M, Mehra, Rahul, Mehrabani-Zeinabad, Kamran, Mehrabi Nasab, Entezar, Mekene Meto, Tesfahun, Mendez-Lopez, Max Alberto Mendez, Mendoza, Walter, Menezes, Ritesh G, Mensah, George A, Mentis, Alexios-Fotios A, Meo, Sultan Ayoub, Merati, Mohsen, Meretoja, Atte, Meretoja, Tuomo J, Mersha, Abera M, Mestrovic, Tomislav, Metanat, Pouya, Mettananda, Kukulege Chamila Dinushi, Mettananda, Sachith, Mhlanga, Adquate, Mhlanga, Laurette, Mi, Tianyue, Miazgowski, Tomasz, Micha, Georgia, Michalek, Irmina Maria, Miller, Ted R, Minh, Le Huu Nhat, Mirghafourvand, Mojgan, Mirrakhimov, Erkin M, Mirutse, Mizan Kiros, Mirza, Moonis, Mirzaei, Roya, Mishra, Ashim, Misra, Sanjeev, Mitchell, Philip B, Mittal, Chaitanya, Moazen, Babak, Mohamed, Abdalla Z, Mohamed, Ahmed Ismail, Mohamed, Jama, Mohamed, Mouhand F H, Mohamed, Nouh Saad, Mohammad-Alizadeh-Charandabi, Sakineh, Mohammadi, Soheil, Mohammadian-Hafshejani, Abdollah, Mohammed, Mustapha, Mohammed, Salahuddin, Mohammed, Shafiu, Mokdad, Ali H, Mokhtarzadehazar, Peyman, Molavi Vardanjani, Hossein, Molinaro, Sabrina, Monasta, Lorenzo, Moni, Mohammad Ali, Moradi, Maryam, Moradi, Yousef, Moraga, Paula, Moreira, Rafael Silveira, Morovatdar, Negar, Morrison, Shane Douglas, Morze, Jakub, Mosapour, Abbas, Mossialos, Elias, Motappa, Rohith, Mousavi, Parsa, Mousavi Khaneghah, Amin, Mpundu-Kaambwa, Christine, Mubarik, Sumaira, Muccioli, Lorenzo, Mulita, Francesk, Munjal, Kavita, Murillo-Zamora, Efrén, Musa, Jonah, Musaigwa, Fungai, Musina, Ana-Maria, Muthu, Sathish, Muthupandian, Saravanan, Muzaffar, Muhammad, Myung, Woojae, Nagarajan, Ahamarshan Jayaraman, Nagel, Gabriele, Naghavi, Pirouz, Naik, Ganesh R, Naik, Gurudatta, Naimzada, Mukhammad David, Nainu, Firzan, Nangia, Vinay, Narasimha Swamy, Sreenivas, Nascimento, Bruno Ramos, Nascimento, Gustavo G, Naser, Abdallah Y, Nasiri, Mohammad Javad, Natto, Zuhair S, Nauman, Javaid, Naveed, Muhammad, Nayak, Biswa Prakash, Nayak, Vinod C, Ndejjo, Rawlance, Nduaguba, Sabina Onyinye, Negash, Hadush, Negesse, Chernet Tafere, Negoi, Ionut, Negoi, Ruxandra Irina, Nejadghaderi, Seyed Aria, Nejjari, Chakib, Nepal, Samata, Netsere, Henok Biresaw, Nguefack-Tsague, Georges, Ngunjiri, Josephine W., Nguyen, Dang H, Nguyen, Hau Thi Hien, Nguyen, Phuong The, Nguyen, QuynhAnh P, Nguyen, Van Thanh, Niazi, Robina Khan, Nigatu, Yeshambel T, Nikolouzakis, Taxiarchis Konstantinos, Nikoobar, Ali, Nikpoor, Amin Reza, Nnaji, Chukwudi A, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Noreen, Mamoona, Noroozi, Nafise, Nri-Ezedi, Chisom Adaobi, Nunemo, Mengistu H, Nuñez-Samudio, Virginia, Nurrika, Dieta, Nutor, Jerry John, Oancea, Bogdan, Obamiro, Kehinde O, Odetokun, Ismail A, Odogwu, Nkechi Martina, O'Donnell, Martin James, Odukoya, Oluwakemi Ololade, Oguntade, Ayodipupo Sikiru, Oguta, James Odhiambo, Oh, In-Hwan, Okeke, Sylvester Reuben, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olagunju, Andrew T, Olasupo, Omotola O, Olatubi, Matthew Idowu, Oliveira, Gláucia Maria Moraes, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oluwatunase, Gideon Olamilekan, Omar, Hany A, Omer, Goran Latif, Onwujekwe, Obinna E, Ordak, Michal, Orisakwe, Orish Ebere, Orish, Verner N, Ortega-Altamirano, Doris V, Ortiz, Alberto, Ortiz-Prado, Esteban, Osman, Wael M S, Osuagwu, Uchechukwu Levi, Osuolale, Olayinka, Otoiu, Adrian, Otstavnov, Stanislav S, Ouyahia, Amel, Ouyang, Guoqing, Owolabi, Mayowa O, Ozten, Yaz, P A, Mahesh Padukudru, Pahlevan Fallahy, Mohammad Taha, Pan, Feng, Pan, Hai-Feng, Pana, Adrian, Panda, Paramjot, Panda-Jonas, Songhomitra, Pangaribuan, Helena Ullyartha, Panos, Georgios D, Panos, Leonidas D, Pantazopoulos, Ioannis, Pantea Stoian, Anca Mihaela, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Pashaei, Ava, Passera, Roberto, Patel, Hemal M, Patel, Jay, Patil, Shankargouda, Patoulias, Dimitrios, Patthipati, Venkata Suresh, Paudel, Uttam, Paun, Mihaela, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pedersini, Paolo, Peng, Minjin, Pensato, Umberto, Pepito, Veincent Christian Filipino, Peprah, Prince, Pereira, Gavin, Peres, Mario F P, Perianayagam, Arokiasamy, Perico, Norberto, Perna, Simone, Pestell, Richard G, Petermann-Rocha, Fanny Emily, Pham, Hoang Tran, Philip, Anil K, Pierannunzio, Daniela, Pigeolet, Manon, Pigott, David M, Plotnikov, Evgenii, Poddighe, Dimitri, Pollner, Peter, Poluru, Ramesh, Postma, Maarten J, Pourali, Ghazaleh, Pourshams, Akram, Pourtaheri, Naeimeh, Prabhu, Disha, Prada, Sergio I, Pradhan, Pranil Man Singh, Prasad, Manya, Prashant, Akila, Purohit, Bharathi M, Puvvula, Jagadeesh, Qasim, Nameer Hashim, Qattea, Ibrahim, R, Deepthi, Rabiee Rad, Mehrdad, Radfar, Amir, Radhakrishnan, Venkatraman, Raee, Pourya, Raeisi Shahraki, Hadi, Rafiei, Alireza, Rafiei Alavi, Seyedeh Niloufar, Raggi, Cat, Raghav, Pankaja Raghav, Rahim, Fakher, Rahim, Md Jillur, Rahman, Md. Mosfequr, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmanian, Vahid, Rahmati, Masoud, Rahnavard, Niloufar, Rai, Pramila, Raimondo, Diego, Rajabpour-Sanati, Ali, Rajput, Prashant, Ram, Prasanna, Ramasamy, Shakthi Kumaran, Rana, Juwel, Rana, Kritika, Rana, Shailendra Singh, Ranabhat, Chhabi Lal, Rancic, Nemanja, Rane, Amey, Ranjan, Shubham, Rao, Chythra R, Rao, Indu Ramachandra, Rapaka, Deepthi, Rasella, Davide, Rashedi, Sina, Rashedi, Vahid, Rashidi, Mohammad-Mahdi, Rasul, Azad, Ratan, Zubair Ahmed, Rathnaiah Babu, Giridhara, Rauniyar, Santosh Kumar, Ravikumar, Nakul, Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Rawlley, Bharat, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Reshmi, Bhageerathy, Rezaei, Nazila, Rezaei Nejad, Aida, Rezaeian, Mohsen, Riad, Abanoub, Riaz, Mavra A, Rickard, Jennifer, Rikhtegar, Reza, Robinson-Oden, Hannah Elizabeth, Rodrigues, Célia Fortuna, Rodriguez, Jefferson Antonio Buendia, Rohilla, Ravi, Romadlon, Debby Syahru, Ronfani, Luca, Rout, Himanshu Sekhar, Roy, Bedanta, Roy, Nitai, Roy, Priyanka, Rubagotti, Enrico, Ruela, Guilherme de Andrade, Rumisha, Susan Fred, Runghien, Tilleye, S, Manjula, S N, Chandan, Saad, Aly M A, Saadatian, Zahra, Saber-Ayad, Maha Mohamed, SaberiKamarposhti, Morteza, Sabour, Siamak, Sada, Fatos, Saddik, Basema, Sadee, Bashdar Abuzed, Sadeghi, Ehsan, Sadeghi, Erfan, Saeb, Mohammad Reza, Saeed, Umar, Safi, Sher Zaman, Sagoe, Dominic, Saha, Manika, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahu, Monalisha, Saif, Zahra, Sakshaug, Joseph W, Salamati, Payman, Salami, Afeez Abolarinwa, Saleh, Mohamed A, Salem, Marwa Rashad, Salem, Mohammed Z Y, Salimi, Sohrab, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Samuel, Vijaya Paul, Samy, Abdallah M, Sanabria, Juan, Sanadgol, Nima, Sanna, Francesca, Santric-Milicevic, Milena M, Saqib, Haaris, Saraswathy, Sivan Yegnanarayana Iyer, Saravanan, Aswini, Saravi, Babak, Sarikhani, Yaser, Sarkar, Tanmay, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sathyanarayan, Anudeep, Sayeed, Abu, Sayeed, Md Abu, Scarmeas, Nikolaos, Schlee, Winfried, Schuermans, Art, Schwebel, David C, Schwendicke, Falk, Selvaraj, Siddharthan, Sengupta, Pallav, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Serván-Mori, Edson, Sethi, Yashendra, SeyedAlinaghi, SeyedAhmad, Seyedi, Seyed Arsalan, Seylani, Allen, Shafie, Mahan, Shah, Jaffer, Shah, Pritik A, Shahbandi, Ataollah, Shahid, Samiah, Shahwan, Moyad Jamal, Shaikh, Ahmed, Shaikh, Masood Ali, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Shannawaz, Mohammed, Sharath, Medha, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Manoj, Sharma, Rajesh, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shaw, David H, Shayan, Amir Mehdi, Shayan, Maryam, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shenoy, Manjunath Mala, Shetty, Pavanchand H, Shi, Peilin, Shiferaw, Desalegn, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shittu, Aminu, Shivarov, Velizar, Shokraneh, Farhad, Shool, Sina, Shorofi, Seyed Afshin, Shuja, Kanwar Hamza, Shuval, Kerem, Siddig, Emmanuel Edwar, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simonetti, Biagio, Singal, Anjali, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Jasvinder A, Siraj, Md Shahjahan, Smith, Georgia, Socea, Bogdan, Sokhan, Anton, Solanki, Ranjan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Solomon, Yonatan, Song, Yimeng, Sorensen, Reed J D, Spartalis, Michael, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Stanikzai, Muhammad Haroon, Starodubov, Vladimir I, Starodubova, Antonina V, Stefan, Simona Cătălina, Steiropoulos, Paschalis, Stokes, Mark A, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Swain, Chandan Kumar, Sykes, Bryan L, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabb, Karen M, Tabish, Mohammad, Taheri Soodejani, Moslem, Taiba, Jabeen, Tajbakhsh, Ardeshir, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tareke, Derbie Alemu DA, Tariku, Mengistie Kassahun, Tat, Vivian Y, Tavangar, Seyed Mohammad, Teimoori, Mojtaba, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Terefa, Dufera Rikitu, Tesler, Riki, Teye-Kwadjo, Enoch, Thakur, Ramna, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Tharwat, Samar, Thayakaran, Rasiah, Thomas, Nihal, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Jasmine T, Tran, Nghia Minh, Trihandini, Indang, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Usman, Jibrin Sammani, Vacante, Marco, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van den Eynde, Jef, Varavikova, Elena, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vellingiri, Balachandar, Venugopal, Deneshkumar, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Vinayak, Manish, Violante, Francesco S, Vishwakarma, Mukesh, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Volovat, Simona Ruxandra, Vos, Theo, Vujcic, Isidora S, Wafa, Hatem A, Waheed, Yasir, Wakwoya, Elias Bekele, Wang, Cong, Wang, Denny, Wang, Fang, Wang, Shu, Wang, Yanzhong, Wang, Yuan-Pang, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weiss, Daniel J, Wells, Katherine M, Wen, Yi Feng, Westerman, Ronny, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Willeit, Peter, Wondimagegene, Yohannes Addisu, Wu, Felicia, Xia, Juan, Xiao, Hong, Xu, Gelin, Xu, Suowen, Xu, Xiaoyue, Yadollahpour, Ali, Yaghoobpoor, Shirin, Yaghoobpour, Tina, Yaghoubi, Sajad, Yahaya, Zwanden Sule, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yaribeygi, Habib, Ye, Pengpeng, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yezli, Saber, Yigezu, Amanuel, Yip, Paul, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuan, Chun-Wei, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zamagni, Giulia, Zandi, Milad, Zandieh, Ghazal G Z, Zangiabadian, Moein, Zastrozhin, Mikhail Sergeevich, Zhang, Haijun, Zhang, Meixin, Zhang, Yunquan, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Zielińska, Magdalena, Zou, Zhiyong, Zyoud, Samer H, Murray, Christopher J L, Smith, Amanda E, and Vollset, Stein Emil

Published
2024
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25. Risk of death in Klebsiella pneumoniae bloodstream infections is associated with specific phylogenetic lineages

Author

Fostervold, Aasmund, Raffelsberger, Niclas, Hetland, Marit A.K., Bakksjø, Ragna, Bernhoff, Eva, Samuelsen, Ørjan, Sundsfjord, Arnfinn, Afset, Jan E., Berntsen, Christopher F., Bævre-Jensen, Roar, Ebbesen, Marit H., Gammelsrud, Karianne W., Guleng, Anja D., Handal, Nina, Jakovljev, Aleksandra, Johal, Simreen K., Marvik, Åshild, Natvik, Ane, Sandnes, Rolf-Arne, Tofteland, Ståle, Bjørnholt, Jørgen V., and Löhr, Iren H.

Published
2024
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27. Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

Author

Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, and James E. Crowe

Subjects
Science
Abstract

Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV that is effective at minimal doses in a lethal mouse model of infection. We structurally analyze and characterize the binding mode of a prototypical potent Gn domain-A-binding antibody that blocks attachment and of an antibody that inhibits infection by abrogating the fusion process as previously determined. Surprisingly, the Gn domain-A antibody does not directly block RVFV Gn interaction with the host receptor low density lipoprotein receptor-related protein 1 (LRP1) as determined by a competitive assay. This study identifies a rationally designed combination of human mAbs deserving of future investigation for use in humans against RVFV infection. Using a two-pronged mechanistic approach, we demonstrate the potent efficacy of a rationally designed combination mAb therapeutic.

Published
2023
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28. Confinement size effect on dielectric properties, antimicrobial activity, and recycling of TiO2 quantum dots via photodegradation processes of Congo red dye and real industrial textile wastewater

Author

Mohamed Walied A. A., Abd El-Gawad Hala H., Mousa Hanan A., Handal Hala T., Galal Hoda R., Ibrahem Ibrahem A., El-Beih Ahmed Atef, Fawzy Mona M., Ahmed Mahmoud A. M., Mekkey Saleh D., and Labib Ammar A.

Subjects
quantum dots size, low-temperature modified precipitation method, industrial textile wastewater, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801
Published
2024
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34. The Study of Environmental Exposure of Mothers and Infants Impacted by Large-Scale Agriculture (SEMILLA): Description of the Aims and Methods of a Community-Based Birth Cohort Study

Author

Alexis J. Handal, Fadya Orozco, Stephanie Montenegro, Nataly Cadena, Fabián Muñoz, Eileen Ramírez del Rio, and Niko Kaciroti

Subjects
community-engaged research, endocrine-disrupting chemicals, occupational epidemiology, pregnancy outcomes, Latin America, neurobehavioral development, Pediatrics, RJ1-570
Abstract

Background/Objectives: Women of childbearing age not only reside in agricultural communities but also form an integral part of the agricultural labor force. Limited research investigates the impact of prenatal fungicide exposure on infant health, specifically ethylenebisdithiocarbamates and their toxic by-product, ethylenethiourea (ETU), particularly in occupational settings. This paper describes the background, aims, protocol, and baseline sample characteristics for the SEMILLA study, which investigates prenatal ETU exposure, neonatal thyroid function, infant growth, and neurobehavioral development in an agricultural region of Ecuador. Methods: This cohort study follows pregnant women and their infants up to 18 months of age, incorporating urinary biomarkers and survey data on ETU exposure and infant growth and neurodevelopmental measures. Data collection includes detailed questionnaires, scales, and physical examinations on maternal and infant health and development, as well as environmental factors. Descriptive statistics on key characteristics of the study population at baseline are presented. Results: SEMILLA enrolled 409 participants (72% enrollment rate): 111 agricultural workers (mostly floricultural), 149 non-agricultural workers, and 149 non-workers. Baseline characteristics show comparability between work sector groups, with some economic differences. Conclusions: SEMILLA will provide key evidence on prenatal fungicide exposure and infant development and encompass comprehensive multistage data collection procedures in pregnancy and infancy, focusing on structural and social determinants of health as well as individual-level chemical exposures. The community-based approach has proven essential, even amid challenges like the COVID-19 pandemic. The medium-term objective is to inform sustainable interventions promoting maternal and child health, with a long-term goal to reduce community exposures and improve worker health policies, particularly for women and pregnant workers.

Published
2024
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35. Fabrication and Optimisation of Alumina Nanoporous Membranes for Drug Delivery Applications: A Comparative Study

Author

Lamyaa Osama, Hala T. Handal, Sara A. M. El-Sayed, Emad M. Elzayat, and Mostafa Mabrouk

Subjects
neurodegenerative disorders, implantable nanoporous membranes, AAO, SEM, AFM, kinetic studies, Chemistry, QD1-999
Abstract

Neurodegenerative disorders cause most physical and mental disabilities, and therefore require effective treatment. The blood–brain barrier (BBB) prevents drug molecules from crossing from the blood to the brain, making brain drug delivery difficult. Implantable devices could provide sustained and regulated medication to solve this problem. Two electrolytes (0.3 M oxalic acid and 0.3 M sulphuric acid) were used to anodise Al2O3 nanoporous membranes, followed by a third anodisation in concentrated H2SO4 to separate the through-hole membranes from the aluminium substrate. FTIR, AFM, and SEM/EDX were used to characterise the membranes’ structure and morphology. The effects of the anodisation time and electrolyte type on the AAO layer pore density, diameter, interpore distance, and thickness were examined. As a model drug for neurodegenerative disorders, donepezil hydrochloride (DHC) was loaded onto thin alumina nanoporous membranes. The DHC release profiles were characterised at two concentrations using a UV–Vis spectrophotometer. Oxalic acid membranes demonstrated an average pore diameter of 39.6–32.5 nm, which was two times larger than sulphuric acid membranes (22.6–19.7 nm). After increasing the anodisation time from 3 to 5 h, all of the membranes showed a reduction in pore diameter that was stable regardless of the electrolyte type or period. Drug release from oxalic acid-fabricated membranes was controlled and sustained for over 2 weeks. Thus, nanoporous membranes as implantable drug delivery systems could improve neurodegenerative disease treatment.

Published
2024
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36. Efficacy of Local N-Acetylcysteine Administration in Mitigating OHSS Parameters: A Comparative Analysis With Dopaminergic Agonist in the OHSS Model

Author

Dulce Elena Letras-Luna, Nora Hilda Rosas-Murrieta, Nidia Gary Pazos-Salazar, Jorge Flores-Hernández, Francisco Castelán, Berenice Venegas, Alfonso Díaz, Samuel Treviño, Daniel Juárez-Serrano, Wendy Argelia García-Suastegui, Anabella Handal-Silva, and José Luis Morán-Perales

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

In this study, we evaluated the effects of intrabursal administration of cabergoline and N-acetylcysteine on ovarian hyperstimulation syndrome (OHSS) in an immature rat model. The study assessed body, ovarian, and uterine weights, as well as the concentrations of vascular endothelial growth factor A (VEGF-A). Moreover, levels of MDA, 4-HDA, and nitrites were assessed in ovarian homogenates, and vascular permeability was quantified in the peritoneal cavity. Ovarian morphology was characterized using histology and hematoxylin–eosin staining, determining the count of ovarian follicles and corpus luteum. Our results demonstrated a significant increase in lipoperoxidation, nitrite levels, and VEGF-A concentrations in the OHSS group compared to the control group. These biochemical alterations corroborate the successful induction of OHSS in the experimental model. Direct injection into the ovarian bursa resulted in reduced vascular permeability and VEGF-A levels, suggesting that the effects of cabergoline are predominantly ovarian. Particularly, cabergoline did not significantly alter other parameters such as ovarian weight, lipoperoxidation, nitrite levels, or morphology. Conversely, low concentrations of N-acetylcysteine (25–50 µg/kg) significantly reduced ovarian and uterine weights, VEGF-A levels, and vascular permeability. Interestingly, this dose–response relationship was not observed at higher NAC concentrations (100–200 μg/kg), suggesting a potential threshold beyond which NAC loses efficacy in these specific parameters. Our results suggest that the localized administration of N-acetylcysteine shows promise as a therapeutic strategy for OHSS by modulating key parameters associated with the syndrome. These promising results warrant further investigation into its mechanisms and efficacy, potentially expanding therapeutic options for OHSS management.

Published
2024
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37. Risk Factors Associated with Pyogenic Spinal Infections among Intravenous Drug Users and Nonusers

Author

Vivek K. Bilolikar, Brendan Gleason, Lee Kripke, Robert Merrill, Colin Whitaker, and Jon Handal

Subjects
Orthopedic surgery, RD701-811
Abstract

Background Data. Spinal infections are major clinical problems with a substantial financial burden on healthcare systems. Recent increases in primary pyogenic spine infections can be attributed to the opioid epidemic and an aging and increasingly unhealthy population. Immunocompromise, diabetes, and malignancy all predispose patients to spine infections. Purpose. To identify the differences in patient factors, presentation, treatment course, and outcomes of intravenous drug users (IVDA) vs. nonusers (non-IVDA) presenting with pyogenic spinal infections. Study Design/Setting. Retrospective case series. Methods. We identified all cases involving spinal infections at our institution between May 2017 and January 2023. Postsurgical infections were excluded, and patients were separated into IVDA and non-IVDA groups. The patient charts were reviewed and analyzed for statistical or clinically significant differences using RStudio (2019 version 3.6.2). Our institutional review board approved this study, IRB# 2020-277, iRISID-2023-1384. Results. Fifty patients (29 males and 21 females) with primary pyogenic spinal infections were included in our study. There were fourteen patients (28.0%) in the IVDA group. The mean age in the IVDA group was 50.6 vs. 61.9 years (p

Published
2024
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40. Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990–2021: findings from the Global Burden of Disease Study 2021

Author

Gardner, William M, Razo, Christian, McHugh, Theresa A, Hagins, Hailey, Vilchis-Tella, Victor M, Hennessy, Conor, Taylor, Heather Jean, Perumal, Nandita, Fuller, Kia, Cercy, Kelly M, Zoeckler, Leo Zucker, Chen, Catherine S, Lim, Stephen S, Aali, Amirali, Abate, Kalkidan Hassen, Abd-Elsalam, Sherief, Abdurehman, Ame Mehadi, Abebe, Getachew, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Aboye, Girma Beressa Aboye, Abtew, Yonas Derso, Accrombessi, Manfred Mario Kokou, Adane, Denberu Eshetie Adane, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adesina, Miracle Ayomikun, Adeyinka, Daniel Adedayo, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Muhammad Sohail, Afzal, Saira, Agustina, Rina, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Sajjad, Ahmadi, Sepideh, Ahmed, Ayman, Ahmed Rashid, Tarik, Aiman, Wajeeha, Ajami, Marjan, Akbarialiabad, Hossein, Alahdab, Fares, Al-Aly, Ziyad, Alam, Nazmul, Alemayehu, Astawus, Alhassan, Robert Kaba, Ali, Muhammad Ashar, Almustanyir, Sami, Al-Raddadi, Rajaa M, Al-Rifai, Rami H, Altirkawi, Khalid A, Alvand, Saba, Alvis-Guzman, Nelson, Amer, Yasser Sami Abdel Dayem, Ameyaw, Edward Kwabena, Amu, Hubert, Anagaw, Tadele Fentabil, Ancuceanu, Robert, Anoushirvani, Ali Arash, Antwi, Maxwell Hubert, Anvari, Davood, Arabloo, Jalal, Aravkin, Aleksandr Y, Ariffin, Hany, Aripov, Timur, Arja, Asrat, Arndt, Michael Benjamin, Arulappan, Judie, Aruleba, Raphael Taiwo, Ashraf, Tahira, Asresie, Melash Belachew, Athari, Seyyed Shamsadin, Atlaw, Daniel, Aujayeb, Avinash, Awoke, Andargie Abate, Awoke, Mamaru Ayenew, Azadnajafabad, Sina, Azangou-Khyavy, Mohammadreza, B, Darshan B, Badawi, Alaa, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nasser, Bagherieh, Sara, Baig, Atif Amin, Banach, Maciej, Banik, Palash Chandra, Bantie, Abere Tilahun, Barr, Ronald D, Barrow, Amadou, Bashiri, Azadeh, Basu, Saurav, Batiha, Abdul-Monim Mohammad, Begum, Tahmina, Belete, Melaku Ashagrie, Belo, Luis, Bensenor, Isabela M, Berhie, Alemshet Yirga, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhat, Ajay Nagesh, Bhutta, Zulfiqar A, Bikbov, Boris, Billah, Sk Masum, Birara, Setognal, Bishai, Jessica Devin, Bitaraf, Saeid, Boloor, Archith, Botelho, João Silva Botelho, Burkart, Katrin, Calina, Daniela, Cembranel, Francieli, Chakraborty, Promit Ananyo, Chanie, Gashaw Sisay, Chattu, Vijay Kumar, Chien, Ju-Huei, Chukwu, Isaac Sunday, Chung, Eunice, Criqui, Michael H, Cruz-Martins, Natália, Dadras, Omid, Dagnew, Gizachew Worku, Dai, Xiaochen, Danawi, Hadi A, Dandona, Lalit, Dandona, Rakhi, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, De la Cruz-Góngora, Vanessa, Demisse, Fitsum Wolde, Demissie, Solomon, Demsie, Desalegn Getnet, Desai, Hardik Dineshbhai, Desalegn, Markos Desalegn, Dessalegn, Fikadu Nugusu, Dessie, Gashaw, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dhingra, Sameer, Diaz, Daniel, Didehdar, Mojtaba, Dirac, M Ashworth, Diress, Mengistie, Doaei, Saeid, Dodangeh, Milad, Doku, Paul Narh, Dongarwar, Deepa, Dora, Bezabih Terefe, Dsouza, Haneil Larson, Edinur, Hisham Atan, Ekholuenetale, Michael, Elagali, Ahmed Elabbas Mustafa, Elbahnasawy, Mostafa Ahmed, Elbarazi, Iffat, ElGohary, Ghada Metwally Tawfik, Elhadi, Muhammed, El-Huneidi, Waseem, Elmonem, Mohamed A, Enyew, Daniel Berhanie, Eshetu, Habitu Birhan, Ewald, Samuel B, Ezzeddini, Rana, Fagbamigbe, Adeniyi Francis, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fekadu, Ginenus, Feyisa, Bikila Regassa, Fischer, Florian, Fitzgerald, Ryan, Foroutan, Masoud, Fowobaje, Kayode Raphael, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gaipov, Abduzhappar, Galali, Yaseen, Galehdar, Nasrin, Garg, Priyanka, Garg, Tushar, Gebremariam, Yosef Haile, Gebremedhin, Ketema Bizuwork, Gebremichael, Berhe, Gela, Yibeltal Yismaw, Gerema, Urge, Getacher, Lemma, Ghaffari, Kazem, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghashghaee, Ahmad, Gholamalizadeh, Maryam, Ghozy, Sherief, Gizaw, Abraham Tamirat T, Glasbey, James C, Golechha, Mahaveer, Goleij, Pouya, Golitaleb, Mohamad, Goulart, Alessandra C, Goyomsa, Girma Garedew, Guadie, Habtamu Alganeh, Gubari, Mohammed Ibrahim Mohialdeen, Gudisa, Zewdie, Gunawardane, Damitha Asanga, Gupta, Rahul, Gupta, Rajat Das, Gupta, Sapna, Gupta, Vivek Kumar, Guta, Alemu, Habibzadeh, Parham, Hamidi, Samer, Handal, Alexis J, Hanif, Asif, Hannan, Md Abdul, Harapan, Harapan, Harorani, Mehdi, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hasani, Hamidreza, Hassankhani, Hadi, Hassen, Mohammed Bheser, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Hess, Sonja Y, Heyi, Demisu Zenbaba, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hossain, Sheikh Jamal, Hosseini, Kaveh, Hosseini, Mohammad-Salar, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Huang, Junjie, Hussain, Salman, Hussien, Foziya Mohammed, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Immurana, Mustapha, Inbaraj, Leeberk Raja, Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, J, Linda Merin, Jamshidi, Elham, Janodia, Manthan Dilipkumar, Jayarajah, Umesh, Jayaram, Shubha, Jebai, Rime, Jemal, Bedru, Jeyakumar, Angeline, Jha, Ravi Prakash, Jonas, Jost B, Joseph, Nitin, Jozwiak, Jacek Jerzy, Kabir, Ali, Kalankesh, Laleh R, Kalhor, Rohollah, Kamal, Vineet Kumar, Kandel, Himal, Kanko, Tesfaye K, Karaye, Ibraheem M, Kashoo, Faizan Zaffar, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Harkiran, Kayode, Gbenga A, Kebede, Adera Debella, Keshri, Vikash Ranjan, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khalid, Nauman, Khammarnia, Mohammad, Khan, Imteyaz A, Khan, Moien AB, Khatab, Khaled, Khazaei, Zaher, Khubchandani, Jagdish, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Sezer, Kompani, Farzad, Kosen, Soewarta, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Kuate Defo, Barthelemy, Kuddus, Mohammed, Kumar, G Anil, Kumar, Naveen, Kumar, Nithin, Kurmi, Om P, Kuti, Oluwatosin, Lal, Dharmesh Kumar, Landires, Iván, Larsson, Anders O, Lassi, Zohra S, Latief, Kamaluddin, Laxmaiah, Avula, Ledda, Caterina, Lee, Sang-woong, Legesse, Samson Mideksa, Liu, Xuefeng, Lorenzovici, László, Machado, Vanessa Sintra Machado, Mahajan, Preetam Bhalchandra, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Elham, Malakan Rad, Elaheh, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Medina, John Robert Carabeo, Mejia-Rodriguez, Fabiola, Mendes, José João Mendes, Mendoza, Walter, Mendoza-Cano, Oliver, Mentis, Alexios-Fotios A, Meresa, Haftu Asmerom, Mestrovic, Tomislav, Miazgowski, Tomasz, Mirghafourvand, Mojgan, Mirica, Andreea, Mirza, Moonis, Misganaw, Awoke, Misra, Sanjeev, Mohammad, Dara K, Mohammadi, Shadieh, Mohammed, Shafiu, Mohan, Syam, Moka, Nagabhishek, Mokdad, Ali H, Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moosavi, Delaram, Moradi, Maryam, Mosapour, Abbas, Mostafavi, Ebrahim, Muche, Temesgen, Mulita, Francesk, Mulu, Getaneh Baye, Murray, Christopher J L, Musina, Ana-Maria, Mustafa, Ghulam, Nagarajan, Ahamarshan Jayaraman, Nair, Tapas Sadasivan, Narasimha Swamy, Sreenivas, Nassereldine, Hasan, Natto, Zuhair S, Nayak, Biswa Prakash, Naz, Shumaila, Negoi, Ionut, Negoi, Ruxandra Irina, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Niazi, Robina Khan, Noori, Maryam, Nowroozi, Ali, Nurrika, Dieta, Nuruzzaman, Khan M, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obaidur, Rahman Md, Obsa, Mohammed Mohammed Suleiman Suleiman, Odhiambo, Julius Nyerere, Ogunsakin, Ropo Ebenezer, Okati-Aliabad, Hassan, Okonji, Osaretin Christabel, Oladunjoye, Adeolu Olufunso, Oladunjoye, Olubunmi Omotola, Olagunju, Andrew T, Olufadewa, Isaac Iyinoluwa, Omar Bali, Ahmed, Omonisi, Abidemi E Emmanuel, Ortiz, Alberto, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Pakzad, Reza, Palicz, Tamás, Pandey, Anamika, Pandya, Apurva Kumar, Papadopoulou, Paraskevi, Pardhan, Shahina, Patel, Jay, Pathak, Ashish, Pathan, Aslam Ramjan, Paudel, Rajan, Paudel, Uttam, Pawar, Shrikant, Pereira, Gavin, Perico, Norberto, Perna, Simone, Perumalsamy, Navaraj, Petcu, Ionela-Roxana, Pickering, Brandon V, Piracha, Zahra Zahid, Pollok, Richard Charles G, Pradhan, Pranil Man Singh, Prashant, Akila, Qattea, Ibrahim, Quazi Syed, Zahiruddin, Rahim, Fakher, Rahimi, Mehran, Rahman, Azizur, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmani, Shayan, Rai, Rajesh Kumar, Raimondo, Ivano, Rajaa, Sathish, Ram, Pradhum, Rana, Juwel, Ranjha, Muhammad Modassar Ali Nawaz, Rao, Chythra R, Rao, Sowmya J, Rashedi, Sina, Rashidi, Mohammad-Mahdi, Rawaf, Salman, Rawal, Lal, Raza, Rabail Zehra, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Richards, Toby, Rickard, Jennifer, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Roshandel, Gholamreza, Roy, Bedanta, Rwegerera, Godfrey M, Saad, Aly M A, Sabour, Siamak, Saddik, Basema, Sadeghi, Malihe, Sadeghian, Saeid, Saeed, Umar, Sahebkar, Amirhossein, Sahoo, Harihar, Salem, Marwa Rashad, Samy, Abdallah M, Sankararaman, Senthilkumar, Santoro, Rocco, Santos, Itamar S, Satpathy, Maheswar, Saya, Ganesh Kumar, Seboka, Binyam Tariku, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Seylani, Allen, Shafeghat, Melika, Shah, Pritik A, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sharew, Mequannent Melaku Sharew, Sharma, Purva, Sheikhi, Rahim Ali, Shenoy, Suchitra M, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Jeevan K, Shetty, Pavanchand H, Shin, Jae Il, Shivalli, Siddharudha, Shivarov, Velizar, Shobeiri, Parnian, Shorofi, Seyed Afshin, Sikder, Mustafa Kamal, Sima, Ali Reza, Simegn, Wudneh, Singh, Jasvinder A, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Sisay, Yordanos, Skryabina, Anna Aleksandrovna, Solomon, Yonatan, Song, Yi, Sorensen, Reed J D, Stanaway, Jeffrey D, Suchdev, Parminder S, Sufiyan, Mu'awiyyah Babale, Sultana, Saima, Szeto, Mindy D, Tabaeian, Seidamir Pasha, Tahamtan, Alireza, Taheri, Majid, Taheri Soodejani, Moslem, Tamir, Zemenu, Tan, Ker-Kan, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tat, Nathan Y, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Thapar, Rekha, Thiyagarajan, Arulmani, Ticoalu, Jansje Henny Vera, Tigabu, Bereket M, Tiyuri, Amir, Tobe-Gai, Ruoyan, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Tusa, Biruk Shalmeno, Ullah, Irfan, Umer, Abdurezak Adem, Unnikrishnan, Bhaskaran, Vacante, Marco, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vart, Priya, Varthya, Shoban Babu, Vaziri, Siavash, Verma, Madhur verma, Veroux, Massimiliano, Vervoort, Dominique, Vu, Linh Gia, Wagaye, Birhanu, Weldegebreal, Fitsum, Wickramasinghe, Nuwan Darshana, Woldemariam, Melat, Wonde, Tewodros Eshete, Wubetie, Gedif Ashebir, Xu, Xiaoyue, Yari, Kheirollah, Yazdanpanah, Fereshteh, Yehualashet, Sisay Shewasinad, Yigit, Arzu, Yiğit, Vahit, Yisihak, Eshetu, Yon, Dong Keon, Yonemoto, Naohiro, Young, Melissa F, Yu, Chuanhua, Yunusa, Ismaeel, Zahir, Mazyar, Zaki, Leila, Zaman, Burhan Abdullah, Zamora, Nelson, Zare, Iman, Zareshahrabadi, Zahra, Zenebe, Getachew Assefa, Zhang, Zhi-Jiang, Zheng, Peng, Zoladl, Mohammad, and Kassebaum, Nicholas J

Published
2023
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45. Cohort Description: Preventing an Opioid Epidemic in Norway – Focusing on Treatment of Chronic Pain (POINT) – A National Registry-Based Study

Author

Hamina A, Odsbu I, Borchgrevink PC, Chen LC, Clausen T, Espnes KA, Gjesdal K, Handal M, Hartikainen S, Hjellvik V, Holter MTS, Høibø T, Kurita GP, Langaas HC, Lid TG, Nøst TH, Sjøgren P, and Skurtveit S

Subjects
opioids, chronic pain, healthcare registers, Infectious and parasitic diseases, RC109-216
Abstract

Aleksi Hamina,1,* Ingvild Odsbu,2,* Petter Christian Borchgrevink,3,4 Li-Chia Chen,5 Thomas Clausen,1 Ketil Arne Espnes,6,7 Kine Gjesdal,8,9 Marte Handal,1,10 Sirpa Hartikainen,11 Vidar Hjellvik,10 Marianne Therese Smogeli Holter,12 Trond Høibø,13 Geana Paula Kurita,14– 16 Harald Christian Langaas,7 Torgeir Gilje Lid,8,9 Torunn Hatlen Nøst,3,17 Per Sjøgren,15 Svetlana Skurtveit1,2 On behalf of the POINT study group1Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 2Department of Mental Disorders, Division of Mental and Physical Health, the Norwegian Institute of Public Health, Oslo, Norway; 3Department of Pain and Complex Disorders, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 4Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 5Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 6Department of Clinical Pharmacology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 7Regional Medicines Information and Pharmacovigilance Centre (RELIS), Department of Clinical Pharmacology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 8Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; 9Center for Alcohol and Drug Research (KORFOR), Stavanger University Hospital, Stavanger, Norway; 10Department of Chronic Diseases, Division of Mental and Physical Health, the Norwegian Institute of Public Health, Oslo, Norway; 11School of Pharmacy, University of Eastern Finland, Kuopio, Finland; 12Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway; 13Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway; 14Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 15Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; 16Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; 17Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway*These authors contributed equally to this workCorrespondence: Ingvild Odsbu, Department of Mental Disorders, Division of Mental and Physical Health, Norwegian Institute of Public Health, PO Box 222 Skøyen, Oslo, 0213, Norway, Tel +47 41454379, Email ingvild.odsbu@fhi.noAim: The POINT project aims to provide evidence to optimise chronic pain management, prevent adverse consequences of opioids, and improve chronic pain patients’ pain relief, functional capacity, and quality of life. We describe the outline of the project and its work packages. More specifically, we describe a cohort of persons with chronic pain and a cohort of long-term opioid users identified from a national registry linkage.Data Sources: The project utilises data from nationwide healthcare and population registers in Norway. Using the Norwegian Prescription Database, we identified a cohort of persons who have been dispensed drugs reimbursed for chronic pain and a cohort of persons who used opioids long term from 2010 to 2019. Data from the Norwegian Registry for Primary Health Care and the Norwegian Patient Registry (2008– 2019), Cancer Registry (1990– 2018) Cause of Death Registry (2010– 2019) and demographic and socioeconomic registers from Statistics Norway (2010– 2019) were linked to the cohorts.Study Population: There were 568,869 participants with chronic pain. Sixty-three percent of the cohort was women, and the mean age was 57.1 years. There were 336,712 long-term opioid users (58.6% women; 60.9 years). In chronic pain and long-term opioid user cohorts, the most frequent musculoskeletal diagnosis was back pain diagnosed in primary care (27.6% and 30.7%). Psychiatric diagnoses were also common.Main Variables: Upcoming studies will utilise psychiatric and somatic diagnoses from the patient registers, drug use from the prescription register, causes of death, demographics, and socioeconomic status (eg, education, income, workability, immigrant status) as exposures or outcomes.Conclusion and Future Plans: The two cohorts have numerous pain-related diagnoses, especially in the musculoskeletal system, and noticeably frequent somatic and psychiatric morbidity. The POINT project also includes later work packages that explore prescriber and patient perspectives around safe and effective treatment of chronic pain.Keywords: opioids, chronic pain, healthcare registers

Published
2022

46. Large variations in all-cause and overdose mortality among >13,000 patients in and out of opioid maintenance treatment in different settings: a comparative registry linkage study

Author

Roman Gabrhelík, Morten Hesse, Blanka Nechanská, Marte Handal, Viktor Mravčík, Christian Tjagvad, Birgitte Thylstrup, Abdu Kedir Seid, Anne Bukten, Thomas Clausen, and Svetlana Skurtveit

Subjects
opioid agonist treatment, opioid maintenance treatment, methadone, buprenorphine, buprenorphine with naloxone, treatment outcomes, Public aspects of medicine, RA1-1270
Abstract

BackgroundOpioid maintenance treatment (OMT) has the potential to reduce mortality rates substantially. We aimed to compare all-cause and overdose mortality among OMT patients while in or out of OMT in two different countries with different approaches to OMT.MethodsTwo nation-wide, registry-based cohorts were linked by using similar analytical strategies. These included 3,637 male and 1,580 female patients enrolled in OMT in Czechia (years 2000–2019), and 6,387 male and 2,078 female patients enrolled in OMT in Denmark (years 2007–2018). The direct standardization method using the European (EU-27 plus EFTA 2011–2030) Standard was employed to calculate age-standardized rate to weight for age. All-cause and overdose crude mortality rates (CMR) as number of deaths per 1,000 person years (PY) in and out of OMT were calculated for all patients. CMRs were stratified by sex and OMT medication modality (methadone, buprenorphine, and buprenorphine with naloxone).ResultsAge-standardized rate for OMT patients in Czechia and Denmark was 9.7/1,000 PY and 29.8/1,000 PY, respectively. In Czechia, the all-cause CMR was 4.3/1,000 PY in treatment and 10.8/1,000 PY out of treatment. The overdose CMR was 0.5/1,000 PY in treatment and 1.2/1,000 PY out of treatment. In Denmark, the all-cause CMR was 26.6/1,000 PY in treatment and 28.2/1,000 PY out of treatment and the overdose CMR was 7.3/1,000 PY in treatment and 7.0/1,000 PY out of treatment.ConclusionCountry-specific differences in mortality while in and out of OMT in Czechia and Denmark may be partly explained by different patient characteristics and treatment systems in the two countries. The findings contribute to the public health debate about OMT management and may be of interest to practitioners, policy and decision makers when balancing the safety and accessibility of OMT.

Published
2023
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47. Design Systems Implementation for Digital Transformation: A Case Study

Author

Handal, Shaden, Koo, Crystal, Adelakun, Olayele, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Álvaro, editor, Ferrás, Carlos, editor, Méndez Porras, Abel, editor, and Jimenez Delgado, Efren, editor

Published
2022
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50. Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy.

Author

Hengel, Holger, Bosso-Lefèvre, Célia, Grady, George, Szenker-Ravi, Emmanuelle, Li, Hankun, Pierce, Sarah, Lebigot, Élise, Tan, Thong-Teck, Eio, Michelle Y, Narayanan, Gunaseelan, Utami, Kagistia Hana, Yau, Monica, Handal, Nader, Deigendesch, Werner, Keimer, Reinhard, Marzouqa, Hiyam M, Gunay-Aygun, Meral, Muriello, Michael J, Verhelst, Helene, Weckhuysen, Sarah, Mahida, Sonal, Naidu, Sakkubai, Thomas, Terrence G, Lim, Jiin Ying, Tan, Ee Shien, Haye, Damien, Willemsen, Michèl AAP, Oegema, Renske, Mitchell, Wendy G, Pierson, Tyler Mark, Andrews, Marisa V, Willing, Marcia C, Rodan, Lance H, Barakat, Tahsin Stefan, van Slegtenhorst, Marjon, Gavrilova, Ralitza H, Martinelli, Diego, Gilboa, Tal, Tamim, Abdullah M, Hashem, Mais O, AlSayed, Moeenaldeen D, Abdulrahim, Maha M, Al-Owain, Mohammed, Awaji, Ali, Mahmoud, Adel AH, Faqeih, Eissa A, Asmari, Ali Al, Algain, Sulwan M, Jad, Lamyaa A, Aldhalaan, Hesham M, Helbig, Ingo, Koolen, David A, Riess, Angelika, Kraegeloh-Mann, Ingeborg, Bauer, Peter, Gulsuner, Suleyman, Stamberger, Hannah, Ng, Alvin Yu Jin, Tang, Sha, Tohari, Sumanty, Keren, Boris, Schultz-Rogers, Laura E, Klee, Eric W, Barresi, Sabina, Tartaglia, Marco, Mor-Shaked, Hagar, Maddirevula, Sateesh, Begtrup, Amber, Telegrafi, Aida, Pfundt, Rolph, Schüle, Rebecca, Ciruna, Brian, Bonnard, Carine, Pouladi, Mahmoud A, Stewart, James C, Claridge-Chang, Adam, Lefeber, Dirk J, Alkuraya, Fowzan S, Mathuru, Ajay S, Venkatesh, Byrappa, Barycki, Joseph J, Simpson, Melanie A, Jamuar, Saumya S, Schöls, Ludger, and Reversade, Bruno

Subjects
Organoids, Animals, Zebrafish, Humans, Epilepsy, Syndrome, Oxidoreductases, Pedigree, Kinetics, Genes, Recessive, Alleles, Adolescent, Child, Child, Preschool, Infant, Female, Male, Protein Domains, Loss of Function Mutation, Preschool, Genes, Recessive
Abstract

Developmental epileptic encephalopathies are devastating disorders characterized by intractable epileptic seizures and developmental delay. Here, we report an allelic series of germline recessive mutations in UGDH in 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia. UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Consistent with being loss-of-function alleles, we show using patients' primary fibroblasts and biochemical assays, that these mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease. Our study defines UGDH as a key player for the production of extracellular matrix components that are essential for human brain development. Based on the incidence of variants observed, UGDH mutations are likely to be a frequent cause of recessive epileptic encephalopathy.

Published
2020

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