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Your search keyword '"He, Jialu"' showing total 137 results
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137 results on '"He, Jialu"'

1. Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy

Author

JIN Bu, CHEN Hanzhang, XU Hudong, CHEN Wanyu, YUAN Ying, ZHAO Tingting, HUANG Xiaolei, HE Jialu, and YU Hong

Subjects
hypertrophic cardiomyopathy (hcm), trimethylamine oxide (tmao), protein kinase a (pka), ryanodine receptor 2 (ryr2), Medicine
Abstract

Objective·To investigate the effects of trimethylamine oxide (TMAO) on cardiac function in mice with hypertrophic cardiomyopathy (HCM) and its potential molecular mechanism.Methods·Mice with myosin heavy chain 6 (Myh6) c.1211G>A (p.R404Q+/-) point mutation were used as the animal model. According to dietary supplementation of TMAO and TMAO inhibitor iodomethylcholine (IMC), the wild type (WT) mice and HCM mice were divided into WT group, HCM group (HCM-1 group, HCM-2 group), WT+TMAO group, HCM+TMAO group and HCM+IMC group, respectively. Left ventricular fraction shortening (FS) and left ventricular posterior wall thickness (LVPW) were assessed by echocardiography in all mice. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum TMAO concentration of mice in the HCM-1 group and WT group. The regularity of myocardial cell arrangement of mice was evaluated by hematoxylin and eosin staining (HE staining). The proportion of myocardial fibrosis was evaluated by Masson staining. The activity of protein kinase A (PKA) in mouse myocardial tissue was detected by PKA kit. The expression of ryanodine receptor 2 (RyR2) and p-RyR2(S2808) in mouse myocardial tissue was detected by Western blotting.Results·The results of echocardiography showed that at 12 months of age, the FS of mice in the WT+TMAO group and HCM+TMAO group were lower than those in the corresponding WT group and HCM-1 group, respectively (P

Published
2024
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26. Inter-group payoff transfer driven by collective reputation promotes cooperation in public goods game.

Author

Wang, Jianwei, Dai, Wenhui, Zhang, Xinyi, He, Jialu, Yu, Fengyuan, and Wu, Yihui

Subjects
PUBLIC goods, REPUTATION, TRANSFER payments, COOPERATION, MOTOR vehicle driving, GAMES
Abstract

How to effectively maintain costly intra-group cooperation has always been a topic of great concern in society. As we all know, inter-group competition is a constructive way to promote intra-group cooperation. Previous inter-group competition mechanisms are primarily based on the total contribution value of all individuals in the group in the current round, which ignore the historical behavior of the group and its members. For comparison, we argue that the introduction of collective reputation which reflects not only the total contribution of the groups in the current round but also the group's historical behavior is necessary for the construction of an inter-group competition model. Furthermore, an excellent collective reputation can help the group obtain more high-quality resources and help the group stand out from the competition. To this end, we introduce a new mechanism of inter-group transfer payment driven by collective reputation and construct a public goods game (PGG) model of inter-group competition to study the dynamic behavior of intra-group cooperation evolution. Two parameters, the proportion of accepted groups a and the proportion of transferred groups b , are introduced. The simulation results suggest that the effectiveness of this model in promoting cooperation depends largely on the joint settings of a and b. And in most cases, the combination of small a and medium b plays the significant role. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Research on Capacitor-Switching Semi-Full-Bridge Submodule of Modular Multilevel Converter Using Si-IGBT and SiC-MOSFET

Author

He Jialu, Lei Lin, and Chen Xu

Subjects
Materials science, business.industry, Energy Engineering and Power Technology, Insulated-gate bipolar transistor, Modular design, Topology, Power (physics), law.invention, chemistry.chemical_compound, Capacitor, chemistry, law, MOSFET, Silicon carbide, Full bridge, Piecewise, Electrical and Electronic Engineering, business
Abstract

This article presents a capacitor-switching semi-full-bridge (CS-SFB) submodule (SM) using Si-IGBT and SiC-MOSFET for a modular multilevel converter (MMC). Compared with the conventional hybrid half-/full-bridge MMC, the CS-SFB MMC has the same dc fault ride-through capability and lower power losses. The conduction loss reduces due to the current sharing phenomenon between Si-IGBTs and SiC-MOSFETs. The switching loss reduces in virtue of the fast recovery characteristic of SiC-diode. The derivation process and working principle of the proposed SM are first introduced. Then, the power loss models are established in the switch, SM, and MMC system levels, respectively. Afterward, the piecewise calculation and simulation results reveal the low-power-loss characteristics of the proposed SM and MMC. Finally, these features are verified by experimental results acquired from a downscaled MMC prototype with Si-IGBTs and SiC-MOSFETs.

Published
2021

37. Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides

Author

Wang, Dali, primary, Wang, Qiwei, additional, Wang, Yuyan, additional, Chen, Peiru, additional, Lu, Xueguang, additional, Jia, Fei, additional, Sun, Yehui, additional, Sun, Tingyu, additional, Zhang, Lei, additional, Che, Fangyuan, additional, He, Jialu, additional, Lian, Liming, additional, Morano, Gemma, additional, Shen, Michael, additional, Ren, Mengqi, additional, Dong, Sijia S., additional, Zhao, Jean J., additional, and Zhang, Ke, additional

Published
2022
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38. Analysis on Circulating Current and Split Capacitor Voltage Balance for Modular Multilevel Converter Based Three-phase Four-wire Split Capacitor DSTATCOM

Author

Lei Lin, He Jialu, and Chen Xu

Subjects
TK1001-1841, Renewable Energy, Sustainability and the Environment, Computer science, business.industry, TJ807-830, Energy Engineering and Power Technology, three-phase four-wire (3P4W), Modular design, distribution static synchronous compensator (DSTATCOM), Renewable energy sources, law.invention, Capacitor, Production of electric energy or power. Powerplants. Central stations, Transformation (function), Three-phase, Control theory, law, Capacitor voltage, modular multilevel converter (MMC), Circulating current, split capacitor, Current (fluid), business
Abstract

We propose a modular multilevel converter (MMC) based three-phase four-wire (3P4W) split capacitor distribution static synchronous compensator (DSTATCOM), aiming at compensating unbalanced and reactive load currents. Due to the zero-sequence current compensation, the circulating current characteristics of 3P4W MMC-DSTATCOM are different from conventional MMCs. Moreover, the distinct working principle of MMC would affect the features of split capacitor voltage. The decoupled positive-, negative- and zero-sequence second-order and DC components of the circulating current are deduced explicitly. Two proportional-integral controllers with dual dq transformation are employed to suppress the positive- and negative-sequence components of second-order circulating current, while quasi proportional-resonance controller is designed to eliminate the zero-sequence component. Besides, the phenomenon of the unbalanced split capacitor voltages is revealed, and fast-tracking balancing method by controlling zero-sequence current flowing through the split capacitors is provided. Digital simulation results verify the accuracy of the analysis and the feasibility of the suppression methods.

Published
2021

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