236 results on '"Heise, M"'
Search Results
2. Structured diabetes self-management education and its association with perceived diabetes knowledge, information, and disease distress: Results of a nationwide population-based study
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Heise, M., Heidemann, C., Baumert, J., Du, Y., Frese, T., Avetisyan, M., and Weise, S.
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- 2022
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3. Provinzielle Götter
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Heise, M. E. and Meyer, M. G.
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- 2019
4. Abdominale Organentnahme
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Heise, M. and Bechstein, W. O.
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- 2020
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5. Seroepidemiological Studies of Arboviruses in Africa
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Gudo, Eduardo Samo, Ali, S., António, V. S., Chelene, I. R., Chongo, I., Demanou, M., Falk, K., Guiliche, O. C., Heinrich, N., Monteiro, V., Muianga, A. F., Oludele, J., Mula, F., Mutuku, F., Amade, N., Alho, P., Betsem, E., Chimbuinhe, Z., Cristovam, A. J., Galano, G., Gessain, A., Harris, E., Heise, M., Inalda, F., Jala, I., Jaszi, E., King, C., Kitron, U., Kümmerer, B. M., LaBeaud, A. D., Lagerqvist, N., Malai, G., Mazelier, M., Mendes, S., Mukoko, D., Ndenga, B., Njouom, R., Pinto, G., Tivane, A., Vu, D. M., Vulule, J., COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, REZAEI, NIMA, Series Editor, Hilgenfeld, Rolf, editor, and Vasudevan, Subhash G., editor
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- 2018
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6. Imagine How Good That Feels: The Impact of Anticipated Positive Emotions on Motivation for Reward Activities
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Heise, M, Werthmann, J, Murphy, F, Tuschen-Caffier, B, Renner, F, Heise, M [0000-0003-2650-8681], Werthmann, J [0000-0002-2312-1249], Murphy, Fionnuala [0000-0001-9180-0174], Renner, F [0000-0002-1692-449X], Apollo - University of Cambridge Repository, and Murphy, F [0000-0001-9180-0174]
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Motivation ,Prospective mental imagery ,Clinical Psychology ,Episodic simulation ,Major depression ,Guided imagery ,Experimental and Cognitive Psychology ,Behavioral activation - Abstract
Funder: Albert-Ludwigs-Universität Freiburg im Breisgau (1016), Background Disease burden and unsatisfactory treatment outcomes call for innovation in treatments of depression. Prospective mental imagery, i.e. future-directed voluntary imagery-based thought, about potentially-rewarding activities may offer a mechanistically-informed intervention that targets deficits in reward processing, a core clinical feature of depression. We propose that the previously described impact of prospective mental imagery on motivation for everyday activities is facilitated by affective forecasting, i.e. predictions about an individual’s emotional response to the imagined activities. Methods Participants (N = 120) self-nominated six activities to engage in over the following week and were randomized to either: (1) an affective forecasting imagery condition (n = 40); (2) a neutral process imagery condition (n = 40); or (3) a no-imagery control condition (n = 40). Results As predicted, increases in motivation ratings from pre to post experimental manipulation were significantly higher following affective forecasting imagery compared to both neutral process imagery (d = 0.62) and no-imagery (d = 0.91). Contrary to predictions, the number of activities participants engaged in did not differ between conditions. Conclusions Results provide initial evidence for a potentially important role of affective forecasting in prospective mental imagery. We discuss how these findings can inform future research aiming to harness prospective mental imagery’s potential for clinical applications.
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- 2022
7. Educational Rights and Wrongs: How COVID-Related Student Math Achievement Losses Distributed and Implications for Equal Educational Opportunity
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Heise, Michael
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- 2024
8. Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort
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Bernuth S, Grimm D, Vollmar J, Darstein F, Mittler J, Heise M, Hoppe-Lotichius M, Galle PR, Lang H, and Zimmermann T
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HCV ,hepatitis C ,DAA ,direct acting antivirals ,liver transplantation ,sofosbuvir ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Sebastian Bernuth,1 Daniel Grimm,1 Johanna Vollmar,1 Felix Darstein,1 Jens Mittler,2 Michael Heise,2 Maria Hoppe-Lotichius,2 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann1 1First Department of Internal Medicine, Transplant Hepatology, 2General-, Abdominal- and Transplant- Surgery, University Medical Center, Johannes Gutenberg University, Mainz, Germany Background: Recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) has been a frequent and relevant problem in the past two decades. This analysis evaluated the efficacy and safety of new interferon (IFN)-free direct-acting antiviral (DAA) therapies in a large real-world cohort of HCV patients after LT.Methods: We retrospectively analyzed a cohort of 157 patients infected with HCV who underwent deceased donor LT between 1997 and 2014. Patient survival, outcome, and side effects of antiviral therapy were assessed.Results: Survival with recurrent HCV genotype 1 (GT1) infection was inferior to other HCV GTs (P=0.01). The overall sustained virological response (SVR) rate with new DAA therapy was 94.6% (n=37). Patients with both GT1 and other GTs reached SVR rates >90%. We noticed a few side effects, mainly caused by ribavirin, and only one discontinuation in DAA-treated patients.Conclusion: DAA therapy was effective and safe in previous hard-to-treat patients after LT in this real-world cohort. Keywords: HCV, DAA, liver transplantation, reinfection, sustained virological response, SVR
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- 2017
9. Mechanochemical synthesis, structure, and properties of solid solutions of alkaline earth metal fluorides: Ma1−xMbxF2 (M: Ca, Sr, Ba)
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Heise, M., Scholz, G., Düvel, A., Heitjans, P., and Kemnitz, E.
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- 2016
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10. Zum Zusammenhang zwischen Persönlichkeitsmerkmalen und Burnout-Risiken: Eine Querschnittsstudie unter Medizin- und Psychologiestudierenden
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Waldmann, C., Wolfradt, U., Klement, A., Fuchs, S., Riemenschneider, H., and Heise, M.
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- 2017
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11. Empirical Study of Religious Liberty Decisions (1996-2005)
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Sisk, G. and Heise, M.
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- 2022
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12. Empirical Study of Religious Liberty Decisions (1986-1995)
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Sisk, G. and Heise, M.
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- 2022
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13. Akute Oberbauchblutung durch Ruptur eines Milzarterienaneurysmas in der 37. SSW
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Casteleyn, T, additional, Appelt, M, additional, Kleist, S, additional, Heise, M, additional, and Dressler-Steinbach, I, additional
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- 2022
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14. Hepatocellular carcinoma progression during bridging before liver transplantation
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Renner, P, Da Silva, T, Schnitzbauer, A, Verloh, N, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Sanchez Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, De Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, Renner P., Da Silva T., Schnitzbauer A. A., Verloh N., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Van Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Sanchez Turrion V., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., De Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., Neuhaus P., Renner, P, Da Silva, T, Schnitzbauer, A, Verloh, N, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Sanchez Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, De Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, Renner P., Da Silva T., Schnitzbauer A. A., Verloh N., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Van Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Sanchez Turrion V., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., De Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., and Neuhaus P.
- Abstract
Background: Recipient selection for liver transplantation in hepatocellular carcinoma (HCC) is based primarily on criteria affecting the chance of long-term success. Here, the relationship between pretransplant bridging therapy and long-term survival was investigated in a subgroup analysis of the SiLVER Study. Methods: Response to bridging, as defined by comparison of imaging at the time of listing and post-transplant pathology report, was categorized into controlled versus progressive disease (more than 20 per cent tumour growth or development of new lesions). Results: Of 525 patients with HCC who had liver transplantation, 350 recipients underwent pretransplant bridging therapy. Tumour progression despite bridging was an independent risk factor affecting overall survival (hazard ratio 1.80; P=0.005). For patients within the Milan criteria (MC) at listing, mean overall survival was longer for those with controlled versus progressive disease (6.8 versus 5.8 years; P<0.001). Importantly, patients with HCCs outside the MC that were downsized to within the MC before liver transplantation had poor outcomes compared with patients who never exceeded the MC (mean overall survival 6.2 versus 6.6 years respectively; P=0.030). Conclusion: Patients with HCCs within the MC that did not show tumour progression under locoregional therapy had the best outcomes after liver transplantation. Downstaging into the limits of the MC did not improve the probability of survival. Prognostic factors determining the long-term success of liver transplantation in patients with hepatocellular carcinoma are still under discussion. A subgroup analysis of the SiLVER trial showed that disease control under bridging therapy is strongly associated with improved prognosis in terms of overall survival. However, in tumours exceeding the limits of the Milan criteria, downstaging did not restore the probability of survival compared with that of patients within the Milan criteria.
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- 2021
15. Empirical Study of Religious Liberty Decisions (2006-2015)
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Sisk, G. and Heise, M.
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- 2022
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16. Seltene Differenzialdiagnose der schmerzhaften, geschwollenen weiblichen Leiste
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Bunse, J. and Heise, M.
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- 2016
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17. Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy
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Lachmann, N, Czarnecki, K, Brennig, S, Phaltane, R, Heise, M, Heinz, N, Kempf, H, Dilloo, D, Kaever, V, Schambach, A, Heuser, M, and Moritz, T
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- 2015
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18. mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors
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Schnitzbauer, A, Filmann, N, Adam, R, Bachellier, P, Bechstein, W, Becker, T, Bhoori, S, Bilbao, I, Brockmann, J, Burra, P, Chazoullieres, O, Cillo, U, Colledan, M, Duvoux, C, Ganten, T, Gugenheim, J, Heise, M, van Hoek, B, Jamieson, N, de Jong, K, Klein, C, Klempnauer, J, Kneteman, N, Lerut, J, Makisalo, H, Mazzaferro, V, Mirza, D, Nadalin, S, Neuhaus, P, Pageaux, G, Pinna, A, Pirenne, J, Pratschke, J, Powel, J, Rentsch, M, Rizell, M, Rossi, G, Rostaing, L, Roy, A, Scholz, T, Settmacher, U, Soliman, T, Strasser, S, Soderdahl, G, Troisi, R, Turrion, V, Schlitt, H, Geissler, E, Schnitzbauer AA, Filmann N, Adam RP, Bachellier P, Bechstein WO, Becker T, Bhoori S, Bilbao I, Brockmann J, Burra P, Chazoullieres O, Cillo U, Colledan M, Duvoux C, Ganten TM, Gugenheim J, Heise M, van Hoek B, Jamieson N, de Jong KP, Klein CG, Klempnauer J, Kneteman N, Lerut J, Makisalo H, Mazzaferro V, Mirza DF, Nadalin S, Neuhaus P, Pageaux GP, Pinna AD, Pirenne J, Pratschke J, Powel J, Rentsch M, Rizell M, Rossi G, Rostaing L, Roy AP, Scholz T, Settmacher U, Soliman T, Strasser S, Soderdahl G, Troisi RI, Turrion VS, Schlitt HJ, Geissler EK, Schnitzbauer, A, Filmann, N, Adam, R, Bachellier, P, Bechstein, W, Becker, T, Bhoori, S, Bilbao, I, Brockmann, J, Burra, P, Chazoullieres, O, Cillo, U, Colledan, M, Duvoux, C, Ganten, T, Gugenheim, J, Heise, M, van Hoek, B, Jamieson, N, de Jong, K, Klein, C, Klempnauer, J, Kneteman, N, Lerut, J, Makisalo, H, Mazzaferro, V, Mirza, D, Nadalin, S, Neuhaus, P, Pageaux, G, Pinna, A, Pirenne, J, Pratschke, J, Powel, J, Rentsch, M, Rizell, M, Rossi, G, Rostaing, L, Roy, A, Scholz, T, Settmacher, U, Soliman, T, Strasser, S, Soderdahl, G, Troisi, R, Turrion, V, Schlitt, H, Geissler, E, Schnitzbauer AA, Filmann N, Adam RP, Bachellier P, Bechstein WO, Becker T, Bhoori S, Bilbao I, Brockmann J, Burra P, Chazoullieres O, Cillo U, Colledan M, Duvoux C, Ganten TM, Gugenheim J, Heise M, van Hoek B, Jamieson N, de Jong KP, Klein CG, Klempnauer J, Kneteman N, Lerut J, Makisalo H, Mazzaferro V, Mirza DF, Nadalin S, Neuhaus P, Pageaux GP, Pinna AD, Pirenne J, Pratschke J, Powel J, Rentsch M, Rizell M, Rossi G, Rostaing L, Roy AP, Scholz T, Settmacher U, Soliman T, Strasser S, Soderdahl G, Troisi RI, Turrion VS, Schlitt HJ, and Geissler EK
- Abstract
Objective: The aim of this study was to evaluate the survival benefit of sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis of the SiLVER-trial). Summary and Background Data: Patients receiving LT) for HCC are at a high risk for tumor recurrence. Calcineurin inhibitors have shown evidence to promote cancer growth, whereas mammalian target of rapamycin (mTOR) inhibitors like sirolimus have anticancer effects. In the SiLVER-trial (Clinicaltrials.gov:NCT00355862), the effect of sirolimus on the recurrence of HCC after LTwas investigated in a prospective randomized trial. Although the primary endpoint of improved disease-free survival (DFS) with sirolimus was not met, outcomes were improved for patients in the sirolimus-treatment arm in the first 3 to 5 years. To learn more about the key variables, a multivariate analysis was performed on the SiLVER-trial data. Patients and Methods: Data from 508 patients of the intention-to-treat analysis were included in exploratory univariate and multivariate models for overall survival (OS), DFS and a competing risk analysis for HCC recurrence. Results: Sirolimus use for >= 3 months after LT for HCC independently reduced the hazard for death in the multivariate analysis [hazard ratio (HR): 0.7 (95% confidence interval, CI: 0.52-0.96, P = 0.02). Most strikingly, patients with an alpha-fetoprotein (AFP) >= 10 ng/mL and having used sirolimus for >= 3 months, benefited most with regard to OS, DFS, and HCC-recurrence (HR: 0.49- 0.59, P = 0.0079- 0.0245). Conclusions: mTOR-inhibitor treatment with sirolimus for >= 3 months improves outcomes in LT for HCC, especially in patients with AFP-evidence of higher tumor activity, advocating particularly for mTOR inhibitor use in this subgroup of patients. Clinical Trial Registration: EudraCT: 2005-005362-36 Clinicaltrials.gov: NCT00355862.
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- 2020
19. HCC recurrence in HCV-infected patients after liver transplantation: SiLVER Study reveals benefits of sirolimus in combination with CNIs – a post-hoc analysis
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Werner, J, Hornung, M, Krah, R, Gotz, M, Schnitzbauer, A, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, Werner J. M., Hornung M., Krah R., Gotz M., Schnitzbauer A. A., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Turrion V. S., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., Neuhaus P., Werner, J, Hornung, M, Krah, R, Gotz, M, Schnitzbauer, A, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, Werner J. M., Hornung M., Krah R., Gotz M., Schnitzbauer A. A., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Turrion V. S., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., and Neuhaus P.
- Abstract
Factors affecting outcomes in liver transplant (LTx) recipients with hepatocellular carcinoma (HCC) and hepatitis C viral (HCV) infection include the choice of immunosuppression. Here, we analyzed the HCV+ subgroup of patients from the randomized controlled, international SiLVER Study. We performed a post hoc analysis of 166 HCV+ SiLVER Study patients regarding HCC outcome after LTx. Control patients (group A: n = 88) received mTOR inhibitor (mTORi)-free, calcineurin inhibitor (CNI)-based versus sirolimus-based immunosuppression (group B: n = 78). We found no significant difference regarding HCV-RNA titers between group A and B. Since no effect in group B could be due to variable sirolimus dosing, we split group B into patients receiving sirolimus-based immunosuppression + CNIs for >50% (B1; n = 44) or <50% (B2; n = 34) of the time. While there remained no difference in HCV-RNA titer between groups, HCC recurrence-free survival in group B1 (81.8%) was markedly better versus both group A (62.7%; P = 0.0136) and group B2 (64.7%; P = 0.0326); Interestingly, further subgroup analysis revealed an increase (P = 0.0012) in liver enzyme values in group B2. Taken together, in HCV-infected patients with HCC and LTx, mTORi immunosuppression + CNIs yields excellent outcomes. Unexpectedly, higher levels of liver inflammation and poorer outcomes occur with mTORi monotherapy in the HCV+ subgroup.
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- 2020
20. Mandibular advancement device: prescription in adult dental sleep medicine — guideline of the German Society of Dental Sleep Medicine
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Bernhardt, O. Giannakopoulos, N.N. Heise, M. Meyer, A. Norden, D. Schlieper, J. Kares, H.
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stomatognathic system - Abstract
Purpose: Obstructive sleep apnea (OSA) may result in severe health onditions, reduces quality of live, and affects high percentages of the adult population. Due to recent changes in the German health care regulations, mandibular advancement devices (MAD) will become available as a treatment option for OSA to a greater extent for general dentists and their patients. Methods: A guideline development group consisting of nine members representing four German dental and medical organizations was formed, in order to provide critical information and orientation to the main stakeholders (dentists and patients), regarding the use of MAD for the treatment of OSA within dental sleep medicine. Results: This guideline aims to inform physicians and dentists, particularly those with acquired qualification/specialization in sleep medicine (or in the diagnosis and treatment of sleep-related breathing disorders), as well as experts, payers, and patients. It delivers recommendations on technical requirements for MAD prescription and fabrication, clinical procedures, maintenance, and follow-up procedures. Conclusion: A MAD should be designed for long-term therapy and must be a custom made, adjustable, bimaxillary retained two-splint system equipped with adjustable protrusive elements. The fabrication in a dental laboratory should be based on dental impressions or scans and three-dimensional registrations of the starting position taken with a bite gauge. © 2022, The Author(s).
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- 2022
21. Hepatocellular carcinoma progression during bridging before liver transplantation
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Renner P., Da Silva T., Schnitzbauer A. A., Verloh N., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Van Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Sanchez Turrion V., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., De Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., Neuhaus P., Renner, P, Da Silva, T, Schnitzbauer, A, Verloh, N, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Sanchez Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, De Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, and Publica
- Subjects
Male ,Carcinoma, Hepatocellular ,Time Factor ,Waiting Lists ,AcademicSubjects/MED00910 ,Prognosi ,Risk Factor ,Middle Aged ,Liver Transplantation ,Treatment Outcome ,Liver Neoplasm ,Disease Progression ,Female ,Original Article ,Survival Analysi ,Neoplasm Recurrence, Local ,AcademicSubjects/MED00010 ,Multivariate Analysi ,Human - Abstract
Background Recipient selection for liver transplantation in hepatocellular carcinoma (HCC) is based primarily on criteria affecting the chance of long-term success. Here, the relationship between pretransplant bridging therapy and long-term survival was investigated in a subgroup analysis of the SiLVER Study. Methods Response to bridging, as defined by comparison of imaging at the time of listing and post-transplant pathology report, was categorized into controlled versus progressive disease (more than 20 per cent tumour growth or development of new lesions). Results Of 525 patients with HCC who had liver transplantation, 350 recipients underwent pretransplant bridging therapy. Tumour progression despite bridging was an independent risk factor affecting overall survival (hazard ratio 1.80; P = 0.005). For patients within the Milan criteria (MC) at listing, mean overall survival was longer for those with controlled versus progressive disease (6.8 versus 5.8 years; P
- Published
- 2021
22. Effects of Particulate Matter on SARS-CoV-2 Induced Antiviral Responses in Human Nasal Epithelial Cells
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Brocke, S., primary, Taft-Benz, S., additional, Robinette, C., additional, Knight, N., additional, Heise, M., additional, and Jaspers, I., additional
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- 2021
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23. Prospective Mental Imagery in Depression: Impact on Reward Processing and Reward-Motivated Behaviour.
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Renner, F., Werthmann, J., Paetsch, A., Bär, H.E., Heise, M., Bruijniks, S.J.E., Renner, F., Werthmann, J., Paetsch, A., Bär, H.E., Heise, M., and Bruijniks, S.J.E.
- Published
- 2021
24. FINAL REPORT OF THE PROSPECTIVE-RANDOMIZED MULTICENTER TOP-STUDY: NO BENEFICIAL EFFECT OF AN EX VIVO TACROLIMUS RINSE IN EDC LIVER GRAFTS: P079
- Author
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Pratschke, S., Werner, J., Heise, M., Pascher, A., Schemmer, P., Scherer, M., Ott, M., Arnold, H., Guba, M., and Angele, M.
- Published
- 2014
25. 'Corona-Debriefing': concept and pilot testing of a 90-minute workshop for undergraduate-education and specialist-training in family medicine
- Author
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Klement, A, Ibs, T, Longard, S, Klinkhart, C, Frese, T, Heise, M, Klement, A, Ibs, T, Longard, S, Klinkhart, C, Frese, T, and Heise, M
- Abstract
Background: The corona pandemic is changing the framework conditions for medical studies and continuing education as well as the work with patients and within teams. Systematic reflection and communication about experiences and ways of dealing with them forms the basis for successful learning in and out of the crisis. Therefore, we designed a 90-minute workshop "Corona-Debriefing" for students and physicians in specialist-training in family medicine (ÄiW) using three successive moderated interaction phases: Questionnaire survey via tele-dialogue voting (TED) with immediate presentation of results and discussion, moderated experience reports on the categories risk/assessment/support/coping and finally moderated group discussions in small groups to collect "best practice" examples of crisis management. Objective: We tested "Corona-Debriefing" as a pilot test with 48 participants (TN) in July 2020 (30 present, 14 online) in order to assess mental stress and risk perception of participants plus formative/brief summative evaluation of the workshop. Methods: The PHQ-4 with its subscales GAD-2 (anxiety) and PHQ-2 (depression) was used to assess mental stress; risk assessments were made by means of self-constructed 5-point Likert-scales for the dimensions person/society/health/economy. A formative evaluation was carried out by means of a questionnaire at the end of the event; the brief summative assessment was asked for by means of a school grading scale. Results: 37 complete TED questionnaires and 22 evaluations were obtained. TN showed a low personal risk assessment, but considerable fears about social and economic developments. Needs are seen mainly in improvements regarding organization, protective equipment and technical communication (e.g. official recommendations for action). The workshop was rated "good" or "very good" in 95% of the evaluations. Criticism was directed at the limited time available, the narrowing of topics by moderators and the desire for (even) more, Hintergrund: Die Corona-Pandemie verändert die Rahmenbedingungen von Studium und Weiterbildung in der Medizin ebenso wie die Arbeit am Patienten und im Team. Eine systematische Reflektion und Kommunikation über Erfahrungen und Umgangsweisen bildet die Grundlage für ein erfolgreiches Lernen in und aus der Krise. Wir konzipierten daher einen 90-Minuten Workshop "Corona-Debriefing" für Studierende und Ärzt*innen in Weiterbildung (ÄiW) mittels drei aufeinanderfolgenden moderierten Interaktionsphasen: Fragebogenerhebung per Tele-Dialog-Voting (TED) mit unmittelbarer Ergebnisvorstellung und Diskussion, moderierte Erlebnisberichte zu den Kategorien Gefährdung / Bewertung / Unterstützung / Bewältigung und schließlich moderierte Gruppendiskussionen in Kleingruppen zur Sammlung von "Best-Practice" - Beispielen zur Krisenbewältigung. Ziele: Wir erprobten "Corona-Debriefing" als Pilottest mit 48 ÄiW als Teilnehmern (TN) im Juli 2020 (30 präsent, 14 online) mit den Auswertungszielen psychische Belastung / Gefährdungseinschätzung der TN, inhaltliche Schwerpunkte, technische Umsetzung, Gesamtbewertung und Kritik am Format. Methoden: Zur Erfassung der psychischen Belastung diente der PHQ-4 mit seinen Subskalen GAD-2 (Ängstlichkeit) und PHQ-2 (Depressivität); Gefährdungseinschätzungen wurden mit selbstkonstruierten 5-Punkt-Likert-Skalen zu den Dimensionen Person/Gesellschaft/Gesundheit/Ökonomie erhoben. Eine formative und Evaluation erfolgte mittels Fragebogen am Veranstaltungsende, die Gesamtbewertung wurde mittels Schulnotenskala erfragt. Ergebnisse: Ausgewertet werden konnten 37 komplette TED-Fragebögen und 22 Evaluationen. TN zeigten eine geringe persönliche Gefährdungseinschätzung, jedoch erhebliche Befürchtungen zu gesellschaftlichen und ökonomischen Entwicklungen. Bedarfe werden v.a. in Organisation, Schutzausrüstung und fachlicher Kommunikation (z.B. offiziellen Handlungsempfehlungen) gesehen. Der Workshop wurde in 95% der Evaluationen "gut" oder "sehr gut" bewertet. Kritik
- Published
- 2020
26. New 2D layered structures with direct fluorine–metal bonds: MF(CH3COO) (M: Sr, Ba, Pb)
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Zänker, S., primary, Scholz, G., additional, Heise, M., additional, Emmerling, F., additional, and Kemnitz, E., additional
- Published
- 2020
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27. Ist die Teilnahme an Patientenschulungen für Typ 2 Diabetes mellitus mit einem verbesserten Lebensstil assoziiert?
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Carmienke, S, Heise, M, Frese, T, Baumert, J, Heidemann, C, Gabrys, L, and Fink, A
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Hintergrund: In randomisiert-kontrollierten Studien konnten strukturierte Patientenschulungen (DSME) das Lebensstilverhalten von Menschen mit Diabetes mellitus (DM) verbessern. Es fehlen jedoch Daten zur Assoziation von Schulungsteilnahme und Lebensstil in der Routineversorgung. Fragestellung: [zum vollständigen Text gelangen Sie über die oben angegebene URL], 53. Kongress für Allgemeinmedizin und Familienmedizin
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- 2019
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28. Misdemeanor Appeals
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Nancy King and Heise, M.
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LawArXiv|Law|Criminal Procedure ,LawArXiv|Law|Criminal Law ,bepress|Law|Criminal Procedure ,LawArXiv|Law ,bepress|Law ,bepress|Law|Criminal Law - Abstract
Misdemeanor cases affect far more people than felony cases, outnumbering felony cases by more than three to one. Yet very little empirical information exists on many aspects of misdemeanor prosecutions. This Article provides the first quantitative look at appellate review in misdemeanor cases, nationwide. It uses data drawn from a random sample of direct criminal appeals decided by every state appellate court in the nation, unpublished aggregate data on misdemeanor trial court cases provided by the Court Statistics Project, and published state court statistics.We provide the first estimate of the rate of appellate review for misdemeanors, concluding that appellate courts review no more than eight in 10,000 misdemeanor convictions, and disturb only one conviction or sentence out of every 10,000 misdemeanor judgments. This level of oversight is much lower than that for felony cases, for reasons we explain. To develop law and regulate error in misdemeanor cases, particularly in prosecutions for the lowest-level offenses, courts may need to provide mechanisms for judicial scrutiny outside the direct appeal process.Additional findings include new information about the rate of felony trial court review of lower court misdemeanor cases, ratios of appeals to convictions for various misdemeanor-crime categories, detailed descriptive information about misdemeanor cases that reach state appellate courts, the results of a complete statistical analysis examining which features are significantly associated with a greater or lesser likelihood of success, including crime type, claim raised, judicial-selection method, and type of representation, and the first quantitative look at how misdemeanor appeals differ from felony appeals.
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- 2019
29. Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation
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Vollmar J, Bellmann MC, Darstein F, Hoppe-Lotichius M, Mittler J, Heise M, Rüttger B, Weyer V, Zimmermann A, Lang H, Galle PR, and Zimmermann T
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lcsh:Therapeutics. Pharmacology ,lcsh:RM1-950 ,humanities - Abstract
Johanna Vollmar,1 Maren Christina Bellmann,1 Felix Darstein,1 Maria Hoppe-Lotichius,2 Jens Mittler,2 Michael Heise,2 Bernd Rüttger,3 Veronika Weyer,4 Anca Zimmermann,5 Hauke Lang,2 Peter R Galle,1 Tim Zimmermann1 1First Department of Internal Medicine, Gastroenterology and Hepatology, Johannes Gutenberg University, Mainz, Germany; 2Department of Hepatobiliary and Transplantation Surgery, Johannes Gutenberg University, Mainz, Germany; 3Panacea Biotec Germany GmbH, Munich, Germany; 4Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany; 5First Department of Internal Medicine, Endocrinology and Metabolic Diseases, Johannes Gutenberg University, Mainz, Germany Background: Expensive pharmaceuticals are a major reason for cost intensive health care systems. Long-term immunosuppressive therapy plays a relevant role after organ transplantation. Patents of original drugs have expired and cheaper products are available. Little data are available regarding efficacy and safety of generic immunosuppressive agents.Methods: In this prospective study, 25 patients, who were clinically stable for a minimum of 2 years after liver transplantation, were converted from the original formulations of tacrolimus (TAC) and mycophenolate mofetil to the generics Tacpan® (TAP) and Mowel® (MOW). Patients were followed-up for 6 months. Results were compared retrospectively to 25 age- and sex-matched controls treated with the original brands.Results: In the matched-pair analysis of TAC trough level/dose ratio, no significant difference was found between TAP/MOW and TAC/mycophenolate mofetil groups. No acute rejection occurred in either group. In total, 17 patients reported mild side effects in the TAP/MOW group. The most common side effects were gastrointestinal symptoms. Intra-individual analysis of costs revealed a considerable cost reduction in the TAP/MOW group (in median 25.03%; P
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- 2015
30. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial
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Geissler, E, Schnitzbauer, A, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, de Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Mirza, D, Otto, G, Mazzaferro, V, Neuhaus, P, Schlitt, H, Geissler EK, Schnitzbauer AA, Zulke C, Lamby PE, Proneth A, Duvoux C, Burra P, Jauch KW, Rentsch M, Ganten TM, Schmidt J, Settmacher U, Heise M, Rossi G, Cillo U, Kneteman N, Adam R, van Hoek B, Bachellier P, Wolf P, Rostaing L, Bechstein WO, Rizell M, Powell J, Hidalgo E, Gugenheim J, Wolters H, Brockmann J, Roy A, Mutzbauer I, Schlitt A, Beckebaum S, Graeb C, Nadalin S, Valente U, Turrion VS, Jamieson N, Scholz T, Colledan M, Fandrich F, Becker T, Soderdahl G, Chazouilleres O, Makisalo H, Pageaux GP, Steininger R, Soliman T, de Jong KP, Pirenne J, Margreiter R, Pratschke J, Pinna AD, Hauss J, Schreiber S, Strasser S, Klempnauer J, Troisi RI, Bhoori S, Lerut J, Bilbao I, Klein CG, Konigsrainer A, Mirza DF, Otto G, Mazzaferro V, Neuhaus P, Schlitt HJ, Geissler, E, Schnitzbauer, A, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, de Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Mirza, D, Otto, G, Mazzaferro, V, Neuhaus, P, Schlitt, H, Geissler EK, Schnitzbauer AA, Zulke C, Lamby PE, Proneth A, Duvoux C, Burra P, Jauch KW, Rentsch M, Ganten TM, Schmidt J, Settmacher U, Heise M, Rossi G, Cillo U, Kneteman N, Adam R, van Hoek B, Bachellier P, Wolf P, Rostaing L, Bechstein WO, Rizell M, Powell J, Hidalgo E, Gugenheim J, Wolters H, Brockmann J, Roy A, Mutzbauer I, Schlitt A, Beckebaum S, Graeb C, Nadalin S, Valente U, Turrion VS, Jamieson N, Scholz T, Colledan M, Fandrich F, Becker T, Soderdahl G, Chazouilleres O, Makisalo H, Pageaux GP, Steininger R, Soliman T, de Jong KP, Pirenne J, Margreiter R, Pratschke J, Pinna AD, Hauss J, Schreiber S, Strasser S, Klempnauer J, Troisi RI, Bhoori S, Lerut J, Bilbao I, Klein CG, Konigsrainer A, Mirza DF, Otto G, Mazzaferro V, Neuhaus P, and Schlitt HJ
- Abstract
Background.We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC). Methods. In a prospective-randomized open-label international trial, 525 LTx recipients with HCC initially receiving mammalian target of rapamycin inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on mammalian target of rapamycin inhibitor-free immunosuppression (group A: 264 patients) or a group incorporating sirolimus (group B: 261). The primary endpoint was recurrence-free survival (RFS); intention-To-Treat (ITT) analysis was conducted after 8 years. Overall survival (OS) was a secondary endpoint. Results. Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of RFS rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, OS (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, patients benefited most fromsirolimus; furthermore, younger recipients (age ≤60) also benefited, as well sirolimus monotherapy patients. Serious adverse event numbers were alike in groups A (860) and B (874). Conclusions. Sirolimus in LTx recipients with HCC does not improve long-Term RFS beyond 5 years. However, a RFS and OS benefit is evident in the first 3 to 5 years, especially in low-risk patients. This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with HCC.
- Published
- 2016
31. Subjektiv erlebte Arbeitsbelastung in der Weiterbildung Allgemeinmedizin und daraus resultierende Anforderungen an Kompetenzzentren – eine Querschnittsstudie mit WeiterbildungsassistentInnen in Sachsen-Anhalt
- Author
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Köhler, S, Heise, M, and Frese, T
- Subjects
ddc: 610 ,Weiterbildung ,Kompetenzzentrum für Allgemeinmedizin ,610 Medical sciences ,Medicine ,Arbeitsbelastung - Abstract
Hintergrund: Hohe Arbeitsbelastung sowie hohes Stressempfinden wirken sich negativ auf die psychische Gesundheit aus, erhöhen Risiken psychischer Erkrankungen und begleiten junge ÄrztInnen in den Berufseinstieg und bis hin zur Niederlassung. Kompetenzzentren für Weiterbildung im Fach [zum vollständigen Text gelangen Sie über die oben angegebene URL], 52. Kongress für Allgemeinmedizin und Familienmedizin
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- 2018
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32. Forts and megafortresses, natural and artificial barriers
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Sauer, Eberhard W., Nokandeh, J., Omrani Rekavandi, H., M. , Bagher Bayati, Caputo, F., Heise, M., Intagliata, Emanuele Ettore, Mahmoudi, M., Mohammadkhani, K., Perini, S., Ricci, A., Safari, E., Safari, B., Shumilovskikh, L., Amirinezhad, A., Arteghi, B., Asghari, Z., Hopper, K., Hossein-Zadeh, M., Jahed, M., Jürcke, F., Lawrence, D., Taghi Maleka, M., Mansouri, M., Mirmousavi, M., Mohammadkhani, S., Priestman, S., Reza Rahimi, M., Rahmani, M., Ruchonnet, A., Salari, A., Taji, D., Azizi Kharagani, M. H., Khanipour, M., and Naseri, R.
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- 2018
33. Mechanochemical synthesis, structure and properties of lead containing alkaline earth metal fluoride solid solutions MxPb1-xF2 (M = Ca, Sr, Ba)
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Heise, M., Scholz, G., Düvel, Andre, Heitjans, Paul, and Kemnitz, E.
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Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie ,ddc:540 ,Impedance spectroscopy ,19F MAS NMR spectroscopy ,Mechanochemical synthesis ,Solid solutions - Abstract
The paper deals with the mechanochemical synthesis of lead containing alkaline earth metal fluoride solid solutions MxPb1-xF2 (M = Ca, Sr, Ba) by high-energy ball milling. Several metal precursors and fluorinating agents were tested for synthesizing M0.5Pb0.5F2. Metal acetates and ammonium fluoride as precursors show the most promising results and were therefore used for the formation of MxPb1-xF2 with different metal cationic ratios. The characterization of the local fluorine coordination and the crystal structure was performed by 19F MAS NMR spectroscopy and X-ray diffraction. Additional calculations of 19F chemical shifts using the superposition model allow a deeper insight into the local structure of the compounds. The fluoride ion conductivity was followed by temperature dependent DC conductivity measurements. Significantly higher conductivities were found in comparison with those of the corresponding binary fluorides. The highest values were observed for samples with high lead content M0.25Pb0.75F2, bearing in mind the much higher conductivity of PbF2 compared to MF2.
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- 2018
34. Luminescent properties of Eu3+ doped CaF2, SrF2, BaF2 and PbF2 powders prepared by high-energy ball milling
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Heise, M., primary, Scholz, G., additional, Krahl, T., additional, and Kemnitz, E., additional
- Published
- 2019
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35. Surgical duct-to-duct reconstruction – A novel approach to biliary anastomotic stricture after deceased donor liver transplantation
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Mittler, J., primary, Heinrich, S., additional, Heise, M., additional, Hoppe-Lotichius, M., additional, Klöckner, R., additional, Schad, A., additional, Zimmermann, T., additional, Galle, P.R., additional, and Lang, H., additional
- Published
- 2019
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36. Primary malignant mesenchymal tumors of the liver and the inferior vena cava: a rare tumor entity
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Tripke, V., primary, Huber, T., additional, Heise, M., additional, Heinrich, S., additional, and Lang, H., additional
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- 2019
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37. Multivisceral resection in locally advanced hepatocellular cancer
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Mohr, I., primary, Hoppe-Lotichius, M., additional, Heinrich, S., additional, Otto, G., additional, Heise, M., additional, Galle, P.R., additional, Lang, H., additional, and Mittler, J., additional
- Published
- 2019
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38. Transplantable HCC in resectable cirrhosis – to resect or to transplant?
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Mittler, J., primary, Heinrich, S., additional, Heise, M., additional, Hoppe-Lotichius, M., additional, Otto, G., additional, Klöckner, R., additional, Düber, C., additional, Zimmermann, T., additional, Galle, P.R., additional, and Lang, H., additional
- Published
- 2019
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39. Development of portal hypertension and spleen size after orhtotopic liver transplantation
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Alghdban, K., primary, Zimmermann, T., additional, Klöckner, R., additional, Hoppe-Lotichius, M., additional, Heise, M., additional, Lang, H., additional, and Mittler, J., additional
- Published
- 2019
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40. Recipient celiac trunk stenosis is a significant risk factor for early hepatic artery thrombosis after liver transplantation
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Mohr, I., primary, Albrecht, M., additional, Hoppe-Lotichius, M., additional, Heise, M., additional, Otto, G., additional, Klöckner, R., additional, Galle, P.R., additional, Zimmermann, T., additional, Lang, H., additional, and Mittler, J., additional
- Published
- 2019
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41. A Familial Congenital Heart Disease with a Possible Multigenic Origin Involving a Mutation in BMPR1A
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Demal, J., additional, Heise, M., additional, Reiz, B., additional, Dogra, D., additional, Braenne, I., additional, Reichenspurner, H., additional, Männer, J., additional, Aherrahrou, Z., additional, Schunkert, H., additional, Erdmann, J., additional, and Abdelilah-Seyfried, S., additional
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- 2019
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42. New 2D layered structures with direct fluorine–metal bonds: MF(CH3COO) (M: Sr, Ba, Pb).
- Author
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Zänker, S., Scholz, G., Heise, M., Emmerling, F., and Kemnitz, E.
- Subjects
X-ray powder diffraction ,COORDINATION polymers ,METAL-metal bonds ,BARIUM fluoride ,POLYMER networks ,ATOMIC radius ,SCANNING electron microscopy ,STRONTIUM ions - Abstract
New coordination polymers with 2D network structures with fluorine directly coordinated to the metal ion were prepared both via mechanochemical synthesis and fluorolytic sol–gel synthesis. Depending on the synthesis route, the samples show different particle sizes, according to SEM imaging. The crystal structures of barium acetate fluoride, strontium acetate fluoride, and lead acetate fluoride (BaF(CH
3 COO), SrF(CH3 COO) and PbF(CH3 COO)) were solved from X-ray powder diffraction data. The structure solution is backed by the results from19 F MAS NMR, FT IR data, and thermal analysis. The calculated chemical shifts of the19 F MAS NMR spectra coincide well with the measured ones. It turns out that the grinding conditions have a remarkable influence on the mechanochemical synthesis and its products. Our systematic study also indicates a strong influence of the atomic radii of Ca, Sr, Ba, and Pb on the success of the syntheses. [ABSTRACT FROM AUTHOR]- Published
- 2020
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43. Liver resection for primary hepatic angiosarcoma: single center experience with 10 cases
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Tripke, V., primary, Heinrich, S., additional, Huber, T., additional, Heise, M., additional, Straub, B., additional, and Lang, H., additional
- Published
- 2018
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44. Die Leberfunktion vor Lebertransplantation bestimmt das Überleben nach Lebertransplantation beim hepatozellulären Karzinom
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Foerster, F, additional, Mittler, J, additional, Darstein, F, additional, Heise, M, additional, Marquardt, JU, additional, Wörns, MA, additional, Weinmann, A, additional, Sälter, L, additional, Hoppe-Lotichius, M, additional, Heinrich, S, additional, Klöckner, R, additional, Pitton, M, additional, Schattenberg, J, additional, Sprinzl, MF, additional, Düber, C, additional, Otto, G, additional, Lang, H, additional, Galle, PR, additional, and Zimmermann, T, additional
- Published
- 2018
- Full Text
- View/download PDF
45. Führt die Einführung eines interdisziplinären Tumorboards zur Verbesserung der Behandlungsergebnisse von Gallenwegstumoren?
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Juratli, M, additional, Hofmann, K, additional, Balaban, Ü, additional, El Youzouri, H, additional, Pession, U, additional, Heise, M, additional, Bechstein, WO, additional, and Schnitzbauer, AA, additional
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- 2018
- Full Text
- View/download PDF
46. Mechanochemical synthesis, structure and properties of lead containing alkaline earth metal fluoride solid solutions M x Pb 1-x F 2 (M = Ca, Sr, Ba)
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Heise, M., primary, Scholz, G., additional, Düvel, A., additional, Heitjans, P., additional, and Kemnitz, E., additional
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- 2018
- Full Text
- View/download PDF
47. Per Pupil and School Safety Spending: An Empirical Perspective
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Heise, Michael and Nance, Jason P.
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- 2022
48. Pilot phase evaluation of the elective general practice class: results of student surveys of the first two years
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Samos, FA, Heise, M, Fuchs, S, Mittmann, S, Bauer, A, Klement, A, Samos, FA, Heise, M, Fuchs, S, Mittmann, S, Bauer, A, and Klement, A
- Abstract
Background: Primary health care in rural regions is currently undergoing a global crisis in respect of the next generation of practitioners. National and international recommendations advise placing greater emphasis upon practical skills and competences in medical studies. It is also in the interest of training the next generation to include mentoring and longitudinal integration of contact to teaching practices for general medicine in an early stage. Consequently, the General Practice Class (KAM) was introduced in Halle in 2011 as an elective with 20 individually mentored students per year, beginning with the first subject-related semester. We are now reporting on the results of the evaluation for the first two years. Method: A standardised online survey was carried out with all students who took part in the KAM in the two years 2011 and 2012 (N=38). For both years the survey was made at the end of the first summer semester on the basis of an adapted version of the Heidelberger Inventar zur Lehrevaluation (Heidelberg Inventory for the Evaluation of Teaching, HILVE-II) and the Berliner Evaluationsinstrument für selbsteingeschätzte, studentische Kompetenzen (Berlin Evaluation Instrument for the self-assessment of student competences, BEvaKomp) . Furthermore, each year the preference for the choice of specialty and location of a medical practice was queried. Predictors for the preference of the chosen specialty and the location of a medical practice were estimated by binary logistic regression analysis. Via univariate evaluations the number of students who reported an increase in knowledge in different areas of competence as a result of the KAM was counted. Correlations between the intention to remain in the KAM and the quality of teaching were evaluated on the basis of bivariate correlations. Results: 48% of the students agreed partly or fully that the KAM seminars enhanced their specialist competence. This individual acquiring of competence in the model project repr, Hintergrund: Die medizinische Grundversorgung in ländlichen Regionen befindet sich weltweit in einer Nachwuchskrise. Internationale und nationale Empfehlungen raten zur Stärkung praktischer Fertigkeiten und Kompetenzen im Medizinstudium. Dazu gehört, auch im Interesse der Nachwuchsbindung, den Kontakt zu allgemeinmedizinischen Lehrpraxen frühzeitig, mentoriert und longitudinal zu integrieren. Dazu wird die Klasse Allgemeinmedizin (KAM) in Halle seit 2011 als Wahlpflichtfach mit 20 individuell mentorierten Studierenden pro Jahr beginnend mit dem ersten Fachsemester durchgeführt. Wir berichten über die Evaluationsergebnisse der ersten zwei Jahre.Methodik: Eine standardisierte Online-Befragung wurde mit allen Teilnehmern der KAM in zwei Jahrgängen 2011 bis 2012 (N=38) durchgeführt. Die Befragung erfolgte jeweils zum Ende des ersten Sommersemesters und nutzte eine adaptierte Version des Heidelberger Inventars zur Lehrevaluation (HILVE-II) und das Berliner Evaluationsinstrument für selbsteingeschätzte, studentische Kompetenzen (BEvaKomp). Ferner wurde jährlich die Präferenz zu Fachgebietswahl und Ort der Niederlassung erfragt. Mittels binär-logistischer Regression wurden Prädiktoren für die Präferenz zur Fachgebietswahl Allgemeinmedizin und Ort der Niederlassung geschätzt. Durch univariate Auswertungen wurden die Anteile der Studierenden ausgezählt, die in verschiedenen Kompetenzbereichen einen Wissenszuwachs durch die KAM berichteten. Zusammenhänge zwischen den beabsichtigten Verbleib in der KAM und der Lehrqualität wurden anhand bivariater Korrelationen ausgewertet. Ergebnisse: 48% der Studierenden stimmten der Aussage eher oder völlig zu, dass die Seminare der KAM bei ihnen zu einer Steigerung der Fachkompetenz geführt haben. Dieser individuelle Kompetenzerwerb im Modellprojekt stellte einen signifikanten Prädiktor für die Präferenz zur Fachgebietswahl Allgemeinmedizin dar (OR 7,98; 95%-KI [1,27-50,27], p= 0,027). Studierende, die das Engagement (r=0,504), die Betreuu
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- 2017
49. Intention-to-treat survival benefit of liver transplantation in patients with hepatocellular cancer
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Lai, Quirino, Vitale, Alessandro, Iesari, Samuele, Finkenstedt, Armin, Mennini, Gianluca, Spoletini, Gabriele, Hoppe-Lotichius, Maria, Vennarecci, Giovanni, Manzia, Tommaso M., Nicolini, Daniele, Avolio, Alfonso Wolfango, Frigo, Anna Chiara, Graziadei, Ivo, Rossi, Massimo, Tsochatzis, Emmanouil, Otto, Gerd, Ettorre, Giuseppe M., Tisone, Giuseppe, Vivarelli, Marco, Agnes, Salvatore, Cillo, Umberto, Lerut, Jan, Lehner, K., Rico Juri, J. M., Heise, M., Dalla Bona, E., Melandro, F., Levi Sandri, G. B., Baiocchi, L., Mocchegiani, F., Bianco, G., Onali, S., Spoletini, Gabriele (ORCID:0000-0002-6855-4515), Avolio, Alfonso W. (ORCID:0000-0003-2491-7625), Agnes, Salvatore (ORCID:0000-0002-3341-4221), Lai, Quirino, Vitale, Alessandro, Iesari, Samuele, Finkenstedt, Armin, Mennini, Gianluca, Spoletini, Gabriele, Hoppe-Lotichius, Maria, Vennarecci, Giovanni, Manzia, Tommaso M., Nicolini, Daniele, Avolio, Alfonso Wolfango, Frigo, Anna Chiara, Graziadei, Ivo, Rossi, Massimo, Tsochatzis, Emmanouil, Otto, Gerd, Ettorre, Giuseppe M., Tisone, Giuseppe, Vivarelli, Marco, Agnes, Salvatore, Cillo, Umberto, Lerut, Jan, Lehner, K., Rico Juri, J. M., Heise, M., Dalla Bona, E., Melandro, F., Levi Sandri, G. B., Baiocchi, L., Mocchegiani, F., Bianco, G., Onali, S., Spoletini, Gabriele (ORCID:0000-0002-6855-4515), Avolio, Alfonso W. (ORCID:0000-0003-2491-7625), and Agnes, Salvatore (ORCID:0000-0002-3341-4221)
- Abstract
The debate about the best approach to select patients with hepatocellular cancer (HCC) waiting for liver transplantation (LT) is still ongoing. This study aims to identify the best variables allowing to discriminate between “high-” and “low-benefit” patients. To do so, the concept of intention-to-treat (ITT) survival benefit of LT has been created. Data of 2,103 adult HCC patients consecutively enlisted during the period 1987-2015 were analyzed. Three rigorous statistical steps were used in order to create the ITT survival benefit of LT: the development of an ITT LT and a non-LT survival model, and the individual prediction of the ITT survival benefit of LT defined as the difference between the median ITT survival with (based on the first model) and without LT (based on the second model) calculated for each enrolled patient. Four variables (Model for End-Stage Liver Disease, alpha-fetoprotein, Milan-Criteria status, and radiological response) displayed a high effect in terms of delta benefit. According to these risk factors, four benefit groups were identified. Patients with three to four factors (“no-benefit group”; n = 405 of 2,103; 19.2%) had no benefit of LT compared to alternative treatments. Conversely, patients without any risk factor (“large-benefit group”; n = 108; 5.1%) yielded the highest benefit from LT reaching 60 months. Conclusion: The ITT transplant survival benefit presented here allows physicians to better select HCC patients waiting for LT. The obtained stratification may lead to an improved and more equitable method of organ allocation. Patients without benefit should be de-listed, whereas patients with large benefit ratio should be prioritized for LT. (Hepatology 2017;66:1910–1919).
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- 2017
50. Risikofaktoren für chronischen Schmerz bei Patienten nach medianer Sternotomie - Eine Pilotsudie
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Carmienke, S., Klement, A., Jentzsch, N., and Heise, M.
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ddc: 610 ,chronischer Schmerzpatient ,Neurotizismus ,610 Medical sciences ,Medicine ,mediane Sternotomie - Abstract
Hintergrund: Chronischer Schmerz (CP) ist mit reduzierter Lebensqualität assoziiert und ein relevanter Kostenfaktor im Gesundheitssystem. Fragestellung: Welche Risikofaktoren sind mit CP nach medianer Sternotomie bei herzchirurgischen Patienten assoziiert? Methoden: Design: Prospektive[zum vollständigen Text gelangen Sie über die oben angegebene URL], 50. Kongress für Allgemeinmedizin und Familienmedizin
- Published
- 2016
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