1. Helicobacter pylori overcomes natural immunity in repeated infections
- Author
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Charlie H. Viiala, M. Priyanthi Kumarasinghe, Barry J. Marshall, Chin Yen Tay, Alma Fulurija, Björn Stenström, Kazufumi Kimura, Mohammed Benghezal, Wei Lu, Hooi C. Ee, K. Mary Webberley, Tobias Schoep, and Helen M. Windsor
- Subjects
0301 basic medicine ,Helicobacter pylori infection ,medicine.medical_specialty ,Case Report ,Case Reports ,reinfection ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Helicobacter ,Medicine ,Innate immune system ,biology ,business.industry ,Public health ,General Medicine ,Helicobacter pylori ,biology.organism_classification ,vaccination ,Virology ,3. Good health ,Vaccination ,natural immunity ,030104 developmental biology ,Immunology ,030211 gastroenterology & hepatology ,business - Abstract
Key Clinical Message Repeated experimental reinfection of two subjects indicates that Helicobacter pylori infection does not promote an immune response protective against future reinfection. Our results highlight the importance of preventing reinfection after eradication, through public health initiatives, and possibly treatment of family members. They indicate difficulties for vaccine development, especially therapeutic vaccines.
- Published
- 2016