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2. Characteristics, management and outcome of Herpes Simplex and Varicella-Zoster virus encephalitis: a multicentre prospective cohort study

Author

Abgrall, Sophie, Argaud, Laurent, Argemi, Xavier, Asseray, Nathalie, Baille, Guillaume, Baldolli, Aurélie, Biberon, Julien, Biron, Charlotte, Blanchet-Fourcade, Geneviève, Blot, Mathieu, Bonnetain, Anne, Botelho-Nevers, Elisabeth, Bourdain, Frédéric, Boutoille, David, Brasme, Hélène, Bruel, Cédric, Bruneel, Fabrice, Buzele, Rodolphe, Canouï, Etienne, Casenave, Philippe, Castan, Bernard, Cazanave, Charles, Cazorla, Céline, Challan-Belval, Thibault, Chavanet, Pascal, Chirouze, Catherine, Chroboczek, Tomasz, Courjon, Johan, De Broucker, Thomas, De La Blanchardière, Arnaud, de Montmollin, Etienne, Degroote, Thècle, Delaroche, Marine, Denes, Eric, Deschanvres, Colin, Diard-Detoeuf, Capucine, Dinh, Aurélien, Epaulard, Olivier, Fillatre, Pierre, Forestier, Emmanuel, Fraisse, Thibault, Froidure, Marie, Gaborit, Benjamin, Gagneux-Brunon, Amandine, Gaillard, Nicolas, Galbois, Arnaud, Godement, Mathieu, Goehringer, François, Gravier, Simon, Greigert, Valentin, Gueit, Isabelle, Guimard, Thomas, Henry, Carole, Hentzien, Maxime, Herbrecht, Jean-Etienne, Jaquet, Pierre, Jommier, Fanny, Katchatourian, Lydie, Kerneis, Solene, Krause, Jessica, Le Cam, Manuela, Le Maréchal, Marion, Le Moal, Gwenael, Le Turnier, Paul, Lecomte, Raphael, Lecompte, Anne-Sophie, Lefaucheur, Romain, Lejeune, Stéphanie, Lescure, Xavier, Lesieur, Olivier, Lesprit, Philippe, Louis, Guillaume, Lucas, Christelle, Mahieu, Rafael, Makinson, Alain, Marc, Guillaune, Maria, Alexandre, Marin, Nathalie, Martin, Aurélie, Martin-Blondel, Guillaume, Martinot, Martin, Mas, Alexandre, Mateu, Philippe, Matt, Morgan, Maulin, Laurence, Mechai, Frédéric, Mira, Jean-Paul, Mutez, Eugénie, Orain, Jérémie, Schieber-Pachart, Anne, Pansu, Nathalie, Patrat-Delon, Solene, Pavese, Patricia, Pelerin, Hélène, Pelonde-Erimée, Véronique, Pierre, Isabelle, Ponscarme, Diane, Psimaras, Dimitri, Puges, Mathilde, Reveillon-Istin, Mathilde, Rheims, Sylvain, Richard-Mornas, Aurélie, Riché, Agnès, Roubeau, Vincent, Ruch, Yvon, Runge, Isabelle, Savini, Hélène, Sonneville, Romain, Stahl, Jean-Paul, Tattevin, Pierre, Tiercelet, Kelly, Touati, Saber, Turmel, Jean-Marie, Tyvaert, Isabelle, Vareil, Marc-Olivier, Vidal-Roux, Magalie, Vitrat, Virginie, Wille, Heidi, Zuber, Mathieu, Canet, Emmanuel, Reignier, Jean, Wang, Adrien, Julien, Gautier, Almoyna-Martinez, Laurent, Bouchaud, Olivier, de Broucker, Thomas, Girard, Nadine, Herrmann, Jean-Louis, Honnorat, Jérome, Mailles, Alexandra, Morand, Patrice, Raffi, François, Roblot, France, Poussier, Léa, and Fillâtre, Pierre

Published
2024
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3. Characteristics, management, and outcomes of patients with infectious encephalitis requiring intensive care: A prospective multicentre observational study

Author

Abgrall, Sophie, Argaud, Laurent, Argemi, Xavier, Baille, Guillaume, Baldolli, Aurélie, Benghanem, Sarah, Bertrand, Kevin, Biberon, Julien, Biron, Charlotte, Fourcade, Geneviève Blanchet, Blot, Mathieu, Bothelo-Nevers, Elisabeth, Bourdain, Frédéric, Boutoille, David, Brasme, Hélène, Bruel, Cédric, Bruneel, Fabrice, Buzele, Rodolphe, Canet, Emmanuel, Canoui, Etienne, Casenave, Philippe, Castan, Bernard, Cazanave, Charles, Cazorla, Céline, Chavanet, Pascal, Chirouze, Catherine, Chroboczek, Tomasz, Courjon, Johan, Da Silva, Daniel, De Broucker, Thomas, De La Blanchardiere, Arnaud, De Montmollin, Etienne, Denes, Eric, Deschanvres, Colin, Dinh, Aurélien, Epaulard, Olivier, Fillatre, Pierre, Forestier, Emmanuel, Fraisse, Thibaut, Gaborit, Benjamin, Gagneux-Brunon, Amandine, Gaillard, Nicolas, Galbois, Arnaud, Godement, Mathieu, Goehringer, François, Goubin, Pascale, Gravier, Simon, Greigert, Valentin, Gueit, Isabelle, Guimard, Thomas, Henry, Carole, Hentzien, Maxime, Jaquet, Pierre, Jomier, Fanny, Jurici, Snejana, Kerneis, Solen, Le Bras, Morgane, Le Marechal, Marion, Le Moal, Gwenael, Le Turnier, Paul, Lecompte, Anne-Sophie, Lecomte, Raphael, Lejeune, Stéphanie, Lescure, François-Xavier, Lesieur, Olivier, Lesprit, Philippe, Louis, Guillaume, Mahieu, Rafael, Makinson, Alain, Marc, Guillaume, Maria, Alexandre, Marin, Nathalie, Martin-Blondel, Guillaume, Martinot, Martin, Mas, Alexandre, Mateu, Philippe, Matt, Morgan, Maulin, Laurence, Mechai, Frédéric, Mutez, Eugénie, Orain, Jérémie, Pachart, Anne, Pansu, Nathalie, Patrat-Delon, Solene, Pavese, Patricia, Pelerin, Hélène, Pelonde-Erimée, Véronique, Pierre, Isabelle, Piet, Emilie, Ponscarme, Diane, Psimaras, Dimitri, Puges, Mathilde, Reignier, Jean, Istin, Mathilde Reveillon, Rheims, Sylvain, Richard-Mornas, Aurélie, Roubeau, Vincent, Ruch, Yvon, Runge, Isabelle, Savini, Hélène, Sonneville, Romain, Stahl, Jean Paul, Tattevin, Pierre, Turmel, Jean-Marie, Tyvaert, Louise, Vareil, Marc-Olivier, Vidal-Roux, Magali, Vitrat, Virginie, Wang, Adrien, Wille, Heidi, Zuber, Mathieu, Almoyna-Martinez, Laurent, Herrmann, Jean-Louis, Honnorat, Jérome, Mailles, Alexandra, Morand, Patrice, Roblot, France, and Stahl, Jean-Paul

Published
2023
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4. Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

Author

Bernstein, David I, Guptill, Jeffrey, Naficy, Abdollah, Nachbagauer, Raffael, Berlanda-Scorza, Francesco, Feser, Jodi, Wilson, Patrick C, Solórzano, Alicia, Van der Wielen, Marie, Walter, Emmanuel B, Albrecht, Randy A, Buschle, Kristen N, Chen, Yao-qing, Claeys, Carine, Dickey, Michelle, Dugan, Haley L, Ermler, Megan E, Freeman, Debra, Gao, Min, Gast, Christopher, Guthmiller, Jenna J, Hai, Rong, Henry, Carole, Lan, Linda Yu-Ling, McNeal, Monica, Palm, Anna-Karin E, Shaw, Dustin G, Stamper, Christopher T, Sun, Weina, Sutton, Victoria, Tepora, Micah E, Wahid, Rahnuma, Wenzel, Heather, Wohlbold, Teddy John, Innis, Bruce L, García-Sastre, Adolfo, Palese, Peter, and Krammer, Florian

Subjects
Clinical Trials and Supportive Activities, Influenza, Immunization, Prevention, Biotechnology, Vaccine Related, Biodefense, Pneumonia & Influenza, Infectious Diseases, Emerging Infectious Diseases, Clinical Research, Prevention of disease and conditions, and promotion of well-being, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 3.4 Vaccines, Infection, Good Health and Well Being, Adjuvants, Immunologic, Adult, Female, Healthy Volunteers, Hemagglutinins, Humans, Influenza Vaccines, Influenza, Human, Male, Vaccination, Vaccines, Attenuated, Vaccines, Inactivated, Clinical Sciences, Medical Microbiology, Public Health and Health Services, Microbiology
Abstract

BackgroundInfluenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the circulating strains. However, antigenic drift can cause considerable mismatches between vaccine and circulating strains, substantially reducing vaccine effectiveness. Moreover, current seasonal vaccines are ineffective against pandemic influenza, and production of a vaccine matched to a newly emerging virus strain takes months. Therefore, there is an unmet medical need for a broadly protective influenza virus vaccine. We aimed to test the ability of chimeric H1 haemagglutinin-based universal influenza virus vaccine candidates to induce broadly cross-reactive antibodies targeting the stalk domain of group 1 haemagglutinin-expressing influenza viruses.MethodsWe did a randomised, observer-blinded, phase 1 study in healthy adults in two centres in the USA. Participants were randomly assigned to one of three prime-boost, chimeric haemagglutinin-based vaccine regimens or one of two placebo groups. The vaccine regimens included a chimeric H8/1, intranasal, live-attenuated vaccine on day 1 followed by a non-adjuvanted, chimeric H5/1, intramuscular, inactivated vaccine on day 85; the same regimen but with the inactivated vaccine being adjuvanted with AS03; and an AS03-adjuvanted, chimeric H8/1, intramuscular, inactivated vaccine followed by an AS03-adjuvanted, chimeric H5/1, intramuscular, inactivated vaccine. In this planned interim analysis, the primary endpoints of reactogenicity and safety were assessed by blinded study group. We also assessed anti-H1 haemagglutinin stalk, anti-H2, anti-H9, and anti-H18 IgG antibody titres and plasmablast and memory B-cell responses in peripheral blood. This trial is registered with ClinicalTrials.gov, number NCT03300050.FindingsBetween Oct 10, 2017, and Nov 27, 2017, 65 participants were enrolled and randomly assigned. The adjuvanted inactivated vaccine, but not the live-attenuated vaccine, induced a substantial serum IgG antibody response after the prime immunisation, with a seven times increase in anti-H1 stalk antibody titres on day 29. After boost immunisation, all vaccine regimens induced detectable anti-H1 stalk antibody (2·2-5·6 times induction over baseline), cross-reactive serum IgG antibody, and peripheral blood plasmablast responses. An unsolicited adverse event was reported for 29 (48%) of 61 participants. Solicited local adverse events were reported in 12 (48%) of 25 participants following prime vaccination with intramuscular study product or placebo, in 12 (33%) of 36 after prime immunisation with intranasal study product or placebo, and in 18 (32%) of 56 following booster doses of study product or placebo. Solicited systemic adverse events were reported in 14 (56%) of 25 after prime immunisation with intramuscular study product or placebo, in 22 (61%) of 36 after immunisation with intranasal study product or placebo, and in 21 (38%) of 56 after booster doses of study product or placebo. Disaggregated safety data were not available at the time of this interim analysis.InterpretationThe tested chimeric haemagglutinin-based, universal influenza virus vaccine regimens elicited cross-reactive serum IgG antibodies that targeted the conserved haemagglutinin stalk domain. This is the first proof-of-principle study to show that high anti-stalk titres can be induced by a rationally designed vaccine in humans and opens up avenues for further development of universal influenza virus vaccines. On the basis of the blinded study group, the vaccine regimens were tolerable and no safety concerns were observed.FundingBill & Melinda Gates Foundation.

Published
2020

5. Characteristics, management and outcome of Herpes Simplex and Varicella-Zoster virus encephalitis: a multicentre prospective cohort study

Author

Poussier, Léa, primary, Mailles, Alexandra, additional, Tattevin, Pierre, additional, Stahl, Jean-Paul, additional, Fillâtre, Pierre, additional, Abgrall, Sophie, additional, Argaud, Laurent, additional, Argemi, Xavier, additional, Asseray, Nathalie, additional, Baille, Guillaume, additional, Baldolli, Aurélie, additional, Biberon, Julien, additional, Biron, Charlotte, additional, Blanchet-Fourcade, Geneviève, additional, Blot, Mathieu, additional, Bonnetain, Anne, additional, Botelho-Nevers, Elisabeth, additional, Bourdain, Frédéric, additional, Boutoille, David, additional, Brasme, Hélène, additional, Bruel, Cédric, additional, Bruneel, Fabrice, additional, Buzele, Rodolphe, additional, Canouï, Etienne, additional, Casenave, Philippe, additional, Castan, Bernard, additional, Cazanave, Charles, additional, Cazorla, Céline, additional, Challan-Belval, Thibault, additional, Chavanet, Pascal, additional, Chirouze, Catherine, additional, Chroboczek, Tomasz, additional, Courjon, Johan, additional, De Broucker, Thomas, additional, De La Blanchardière, Arnaud, additional, de Montmollin, Etienne, additional, Degroote, Thècle, additional, Delaroche, Marine, additional, Denes, Eric, additional, Deschanvres, Colin, additional, Diard-Detoeuf, Capucine, additional, Dinh, Aurélien, additional, Epaulard, Olivier, additional, Fillatre, Pierre, additional, Forestier, Emmanuel, additional, Fraisse, Thibault, additional, Froidure, Marie, additional, Gaborit, Benjamin, additional, Gagneux-Brunon, Amandine, additional, Gaillard, Nicolas, additional, Galbois, Arnaud, additional, Godement, Mathieu, additional, Goehringer, François, additional, Gravier, Simon, additional, Greigert, Valentin, additional, Gueit, Isabelle, additional, Guimard, Thomas, additional, Henry, Carole, additional, Hentzien, Maxime, additional, Herbrecht, Jean-Etienne, additional, Jaquet, Pierre, additional, Jommier, Fanny, additional, Katchatourian, Lydie, additional, Kerneis, Solene, additional, Krause, Jessica, additional, Le Cam, Manuela, additional, Le Maréchal, Marion, additional, Le Moal, Gwenael, additional, Le Turnier, Paul, additional, Lecomte, Raphael, additional, Lecompte, Anne-Sophie, additional, Lefaucheur, Romain, additional, Lejeune, Stéphanie, additional, Lescure, Xavier, additional, Lesieur, Olivier, additional, Lesprit, Philippe, additional, Louis, Guillaume, additional, Lucas, Christelle, additional, Mahieu, Rafael, additional, Makinson, Alain, additional, Marc, Guillaune, additional, Maria, Alexandre, additional, Marin, Nathalie, additional, Martin, Aurélie, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Mas, Alexandre, additional, Mateu, Philippe, additional, Matt, Morgan, additional, Maulin, Laurence, additional, Mechai, Frédéric, additional, Mira, Jean-Paul, additional, Mutez, Eugénie, additional, Orain, Jérémie, additional, Schieber-Pachart, Anne, additional, Pansu, Nathalie, additional, Patrat-Delon, Solene, additional, Pavese, Patricia, additional, Pelerin, Hélène, additional, Pelonde-Erimée, Véronique, additional, Pierre, Isabelle, additional, Ponscarme, Diane, additional, Psimaras, Dimitri, additional, Puges, Mathilde, additional, Reveillon-Istin, Mathilde, additional, Rheims, Sylvain, additional, Richard-Mornas, Aurélie, additional, Riché, Agnès, additional, Roubeau, Vincent, additional, Ruch, Yvon, additional, Runge, Isabelle, additional, Savini, Hélène, additional, Sonneville, Romain, additional, Tiercelet, Kelly, additional, Touati, Saber, additional, Turmel, Jean-Marie, additional, Tyvaert, Isabelle, additional, Vareil, Marc-Olivier, additional, Vidal-Roux, Magalie, additional, Vitrat, Virginie, additional, Wille, Heidi, additional, Zuber, Mathieu, additional, Canet, Emmanuel, additional, Reignier, Jean, additional, Wang, Adrien, additional, Julien, Gautier, additional, Almoyna-Martinez, Laurent, additional, Bouchaud, Olivier, additional, de Broucker, Thomas, additional, Girard, Nadine, additional, Herrmann, Jean-Louis, additional, Honnorat, Jérome, additional, Morand, Patrice, additional, Raffi, François, additional, and Roblot, France, additional

Published
2024
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6. Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Author

Guthmiller, Jenna J., Han, Julianna, Utset, Henry A., Li, Lei, Lan, Linda Yu-Ling, Henry, Carole, Stamper, Christopher T., McMahon, Meagan, O’Dell, George, Fernández-Quintero, Monica L., Freyn, Alec W., Amanat, Fatima, Stovicek, Olivia, Gentles, Lauren, Richey, Sara T., de la Peña, Alba Torrents, Rosado, Victoria, Dugan, Haley L., Zheng, Nai-Ying, Tepora, Micah E., Bitar, Dalia J., Changrob, Siriruk, Strohmeier, Shirin, Huang, Min, García-Sastre, Adolfo, Liedl, Klaus R., Bloom, Jesse D., Nachbagauer, Raffael, Palese, Peter, Krammer, Florian, Coughlan, Lynda, Ward, Andrew B., and Wilson, Patrick C.

Published
2022
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7. The Role of Cross-Cultural Experience in Art Teacher Preparation

Author

Henry, Carole and Constantino, Tracie

Abstract

Current research indicates that within the United States, many preservice teachers are not prepared to work with a rapidly changing student population that includes an increasing number of immigrant students with limited proficiency in English (Giambo & Szecsi, 2005/2006; Janzen, 2008; Latta & Chan, 2011). This article presents findings from a longitudinal qualitative study that examined the semester-long experiences of preservice art education students who participated in The University of Georgia Studies Abroad in Cortona, Italy program from 2003 to 2006, providing sequential art instruction to Italian children who were not English speakers. In 2010, we conducted follow-up interviews to better understand the potential long-term effects of this experience. Our findings indicated this experience gave the art education students increased cultural understanding and greater confidence in their teaching, and provided a foundational experience that they believed would help them be more successful in working with English Language Learners (ELLs) in the future.

Published
2015

9. Improved integration of single-cell transcriptome and surface protein expression by LinQ-View

Author

Li, Lei, Dugan, Haley L., Stamper, Christopher T., Lan, Linda Yu-Ling, Asby, Nicholas W., Knight, Matthew, Stovicek, Olivia, Zheng, Nai-Ying, Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Changrob, Siriruk, Utset, Henry A., Henry, Carole, Nelson, Christopher, Jedrzejczak, Robert P., Fremont, Daved H., Joachimiak, Andrzej, Krammer, Florian, Huang, Jun, Khan, Aly A., and Wilson, Patrick C.

Published
2021
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11. Neurologic manifestations associated with COVID-19: a multicentre registry

Author

Abgrall, Sophie, Alby-Laurent, Fanny, Allou, Thibault, Amevigbe, Joséphine, Amarguellay, Hanifa, Alloussi, Nabil, Baille, Guillaume, Barbaz, Mathilde, Bekri, Imen, Bencherif, Lamia, Bensaadi, Samia, Beraud, Guillaume, Bizot, Alexandra, Bottin, Laure, Bruneel, Fabrice, Camdessanche, Jean-Philippe, Chauffier, Jeanne, Csajaghy, Jean-Philippe, De Broucker, Chloé, De Broucker, Thomas, Defebvre, Luc, Delorme, Cécile, Dembloque, Elodie, Derache, Nathalie, Dereeper, Olivier, Derollez, Céline, Descotes-Genon, Cécile, Desestret, Virginie, Devaux, Mathilde, Dubuc, Lydie, Edan, Gilles, Fickl, Andréa, Fraisse, Thibault, Gugenheim, Michel, Hankiewicz, Karolina, Hansmann, Yves, Hautecloque-Raysz, Geoffroy, Henry, Carole, Jobard, Stéphanie, Jouan, Fanny, Kwiatkowski, Arnaud, Lalu, Thibault, Landre, Sophie, Lannuzel, Annie, Leguilloux, Johan, Lejeune, Camille, Liegeois, Clémence, Mahy, Sophie, Marey, Jonathan, Maury, Alexandra, Meppiel, Elodie, Michel, Laure, Mitri, Rita, Moulin, Chloé, Moulin, Solène, Peiffer-Smadja, Nathan, Omarjee, Asma, Ozsancak, Canan, Perrin, Peggy, Petitgas, Paul, Pico, Fernando, Poupard, Marie, Rabier, Valérie, Rizzato, Camille, Roos, Caroline, Saison, Julien, Sayre, Naomi, Sedillot, Nicolas, Sellal, François, Servan, Jérôme, Storey, Caroline, Suchet, Laurent, Tarteret, Paul, Tattevin, Pierre, Thiebaut, Mathilde, Vaduva, Claudia, Varlan, David, Wang, Adrien, Zarrouk, Virginie, Gorza, Lucas, SellaI, François, and de Broucker, Thomas

Published
2021
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12. Characteristics, management, and outcomes of patients with infectious encephalitis requiring intensive care: A prospective multicentre observational study

Author

Fillatre, Pierre, primary, Mailles, Alexandra, additional, Stahl, Jean Paul, additional, Tattevin, Pierre, additional, Abgrall, Sophie, additional, Argaud, Laurent, additional, Argemi, Xavier, additional, Baille, Guillaume, additional, Baldolli, Aurélie, additional, Benghanem, Sarah, additional, Bertrand, Kevin, additional, Biberon, Julien, additional, Biron, Charlotte, additional, Fourcade, Geneviève Blanchet, additional, Blot, Mathieu, additional, Bothelo-Nevers, Elisabeth, additional, Bourdain, Frédéric, additional, Boutoille, David, additional, Brasme, Hélène, additional, Bruel, Cédric, additional, Bruneel, Fabrice, additional, Buzele, Rodolphe, additional, Canet, Emmanuel, additional, Canoui, Etienne, additional, Casenave, Philippe, additional, Castan, Bernard, additional, Cazanave, Charles, additional, Cazorla, Céline, additional, Chavanet, Pascal, additional, Chirouze, Catherine, additional, Chroboczek, Tomasz, additional, Courjon, Johan, additional, Da Silva, Daniel, additional, De Broucker, Thomas, additional, De La Blanchardiere, Arnaud, additional, De Montmollin, Etienne, additional, Denes, Eric, additional, Deschanvres, Colin, additional, Dinh, Aurélien, additional, Epaulard, Olivier, additional, Fillatre, Pierre, additional, Forestier, Emmanuel, additional, Fraisse, Thibaut, additional, Gaborit, Benjamin, additional, Gagneux-Brunon, Amandine, additional, Gaillard, Nicolas, additional, Galbois, Arnaud, additional, Godement, Mathieu, additional, Goehringer, François, additional, Goubin, Pascale, additional, Gravier, Simon, additional, Greigert, Valentin, additional, Gueit, Isabelle, additional, Guimard, Thomas, additional, Henry, Carole, additional, Hentzien, Maxime, additional, Jaquet, Pierre, additional, Jomier, Fanny, additional, Jurici, Snejana, additional, Kerneis, Solen, additional, Le Bras, Morgane, additional, Le Marechal, Marion, additional, Le Moal, Gwenael, additional, Le Turnier, Paul, additional, Lecompte, Anne-Sophie, additional, Lecomte, Raphael, additional, Lejeune, Stéphanie, additional, Lescure, François-Xavier, additional, Lesieur, Olivier, additional, Lesprit, Philippe, additional, Louis, Guillaume, additional, Mahieu, Rafael, additional, Makinson, Alain, additional, Marc, Guillaume, additional, Maria, Alexandre, additional, Marin, Nathalie, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Mas, Alexandre, additional, Mateu, Philippe, additional, Matt, Morgan, additional, Maulin, Laurence, additional, Mechai, Frédéric, additional, Mutez, Eugénie, additional, Orain, Jérémie, additional, Pachart, Anne, additional, Pansu, Nathalie, additional, Patrat-Delon, Solene, additional, Pavese, Patricia, additional, Pelerin, Hélène, additional, Pelonde-Erimée, Véronique, additional, Pierre, Isabelle, additional, Piet, Emilie, additional, Ponscarme, Diane, additional, Psimaras, Dimitri, additional, Puges, Mathilde, additional, Reignier, Jean, additional, Istin, Mathilde Reveillon, additional, Rheims, Sylvain, additional, Richard-Mornas, Aurélie, additional, Roubeau, Vincent, additional, Ruch, Yvon, additional, Runge, Isabelle, additional, Savini, Hélène, additional, Sonneville, Romain, additional, Turmel, Jean-Marie, additional, Tyvaert, Louise, additional, Vareil, Marc-Olivier, additional, Vidal-Roux, Magali, additional, Vitrat, Virginie, additional, Wang, Adrien, additional, Wille, Heidi, additional, Zuber, Mathieu, additional, Almoyna-Martinez, Laurent, additional, Herrmann, Jean-Louis, additional, Honnorat, Jérome, additional, Morand, Patrice, additional, Roblot, France, additional, and Stahl, Jean-Paul, additional

Published
2023
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13. Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2

Author

Stewart-Jones, Guillaume B. E., primary, Elbashir, Sayda M., additional, Wu, Kai, additional, Lee, Diana, additional, Renzi, Isabella, additional, Ying, Baoling, additional, Koch, Matthew, additional, Sein, Caralyn E., additional, Choi, Angela, additional, Whitener, Bradley, additional, Garcia-Dominguez, Dario, additional, Henry, Carole, additional, Woods, Angela, additional, Ma, LingZhi, additional, Montes Berrueta, Daniela, additional, Avena, Laura E., additional, Quinones, Julian, additional, Falcone, Samantha, additional, Hsiao, Chiaowen J., additional, Scheaffer, Suzanne M., additional, Thackray, Larissa B., additional, White, Phil, additional, Diamond, Michael S., additional, Edwards, Darin K., additional, and Carfi, Andrea, additional

Published
2023
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14. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Author

Corbett, Kizzmekia S., Edwards, Darin K., Leist, Sarah R., Abiona, Olubukola M., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T., DiPiazza, Anthony T., Dinnon, Kenneth H., Elbashir, Sayda M., Shaw, Christine A., Woods, Angela, Fritch, Ethan J., Martinez, David R., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Hutchinson, Geoffrey B., Wu, Kai, Henry, Carole, Bahl, Kapil, Garcia-Dominguez, Dario, Ma, LingZhi, Renzi, Isabella, Kong, Wing-Pui, Schmidt, Stephen D., Wang, Lingshu, Zhang, Yi, Phung, Emily, Chang, Lauren A., Loomis, Rebecca J., Altaras, Nedim Emil, Narayanan, Elisabeth, Metkar, Mihir, Presnyak, Vlad, Liu, Cuiping, Louder, Mark K., Shi, Wei, Leung, Kwanyee, Yang, Eun Sung, West, Ande, Gully, Kendra L., Stevens, Laura J., Wang, Nianshuang, Wrapp, Daniel, Doria-Rose, Nicole A., Stewart-Jones, Guillaume, Bennett, Hamilton, Alvarado, Gabriela S., Nason, Martha C., Ruckwardt, Tracy J., McLellan, Jason S., Denison, Mark R., Chappell, James D., Moore, Ian N., Morabito, Kaitlyn M., Mascola, John R., Baric, Ralph S., Carfi, Andrea, and Graham, Barney S.

Published
2020
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19. Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

Author

Neu, Karlynn E., Guthmiller, Jenna J., Huang, Min, La, Jennifer, Vieira, Marcos C., Kim, Kangchon, Zheng, Nai-Ying, Cortese, Mario, Tepora, Micah E., Hamel, Natalie J., Rojas, Karla Thatcher, Henry, Carole, Shaw, Dustin, Dulberger, Charles L., Pulendran, Bali, Cobey, Sarah, Khan, Aly A., and Wilson, Patrick C.

Subjects
Influenza vaccines -- Usage, Influenza -- Prevention, Blood plasma -- Research, Health care industry
Abstract

Vaccines are among the most effective public health tools for combating certain infectious diseases such as influenza. The role of the humoral immune system in vaccine-induced protection is widely appreciated; however, our understanding of how antibody specificities relate to B cell function remains limited due to the complexity of polyclonal antibody responses. To address this, we developed the Spec-seq framework, which allows for simultaneous monoclonal antibody (mAb) characterization and transcriptional profiling from the same single cell. Here, we present the first application of the Spec-seq framework, which we applied to human plasmablasts after influenza vaccination in order to characterize transcriptional differences governed by B cell receptor (BCR) isotype and vaccine reactivity. Our analysis did not find evidence of long-term transcriptional specialization between plasmablasts of different isotypes. However, we did find enhanced transcriptional similarity between clonally related B cells, as well as distinct transcriptional signatures ascribed by BCR vaccine recognition. These data suggest IgG and IgA vaccine-positive plasmablasts are largely similar, whereas IgA vaccine-negative cells appear to be transcriptionally distinct from conventional, terminally differentiated, antigen-induced peripheral blood plasmablasts., IntroductionThe medical field has relied on vaccines for improving human health since the days of smallpox inoculation--long before antibodies were identified (1, 2). Vaccines induce a humoral immune response, in [...]

Published
2019
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20. Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection

Author

Meyer, Michelle, Wang, Yuan, Edwards, Darin, Smith, Gregory R., Rubenstein, Aliza B., Ramanathan, Palaniappan, Mire, Chad E., Pietzsch, Colette, Chen, Xi, Ge, Yongchao, Cheng, Wan Sze, Henry, Carole, Woods, Angela, Ma, LingZhi, Stewart-Jones, Guillaume B.E., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Periasamy, Sivakumar, Shi, Pei-Yong, Graham, Barney S., Moore, Ian N., Ramos, Irene, Troyanskaya, Olga G., Zaslavsky, Elena, Carfi, Andrea, Sealfon, Stuart C., and Bukreyev, Alexander

Subjects
Immunological research, Lung diseases -- Models -- Development and progression -- Prevention, Immune response -- Research, Messenger RNA -- Health aspects -- Physiological aspects, Leukocytes -- Health aspects -- Physiological aspects, Hamsters -- Physiological aspects, Health care industry
Abstract

The mRNA-1273 vaccine is effective against SARS-CoV-2 and was granted emergency use authorization by the FDA. Clinical studies, however, cannot provide the controlled response to infection and complex immunological insight that are only possible with preclinical studies. Hamsters are the only model that reliably exhibits severe SARS-CoV-2 disease similar to that in hospitalized patients, making them pertinent for vaccine evaluation. We demonstrate that prime or prime-boost administration of mRNA-1273 in hamsters elicited robust neutralizing antibodies, ameliorated weight loss, suppressed SARS-CoV-2 replication in the airways, and better protected against disease at the highest prime-boost dose. Unlike in mice and nonhuman primates, low-level virus replication in mRNA-1273-vaccinated hamsters coincided with an anamnestic response. Single-cell RNA sequencing of lung tissue permitted high-resolution analysis that is not possible in vaccinated humans. mRNA-1273 prevented inflammatory cell infiltration and the reduction of lymphocyte proportions, but enabled antiviral responses conducive to lung homeostasis. Surprisingly, infection triggered transcriptome programs in some types of immune cells from vaccinated hamsters that were shared, albeit attenuated, with mock- vaccinated hamsters. Our results support the use of mRNA-1273 in a 2-dose schedule and provide insight into the potential responses within the lungs of vaccinated humans who are exposed to SARS-CoV-2., Introduction When the World Health Organization declared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a global pandemic in March 2020, phase I clinical trials on the most promising vaccine candidates [...]

Published
2021
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22. The radiologically isolated syndrome: revised diagnostic criteria

Author

Lebrun-Frénay, Christine, Okuda, Darin, Siva, Aksel, Landes-Chateau, Cassandre, Azevedo, Christina, Mondot, Lydiane, Carra-Dallière, Clarisse, Zephir, Helene, Louapre, Celine, Durand-Dubief, Françoise, Le Page, Emmanuelle, Bensa, Caroline, Ruet, Aurélie, Ciron, Jonathan, Laplaud, David, Casez, Olivier, Mathey, Guillaume, de Seze, Jerome, Zeydan, Burcu, Makhani, Naila, Tutuncu, Melih, Levraut, Michael, Cohen, Mikael, Thouvenot, Eric, Pelletier, Daniel, Kantarci, Orhun, Sehaki, Sabrina, Devys-Meyer, Nathalie, Bereau, Mathieu, Cappe, Chrystelle, Brochet, Bruno, Ouallet, Jean-Christophe, Kounkou, Katy-Kim, Defer, Gilles, Branger, Pierre, Taithe, Frédéric, Dumont, Emilie, Lescieux, Edwige, Fromont, Agnès, Protin, Alexia, Kane, Maty Diop, Hautecoeur, Patrick, Outteryck, Olivier, Vermersch, Patrick, Boucher, Julie, Petit, Julie, Kasonde, Irène Tabellah, de Vilmarrest, Aymeric, Magy, Laurent, Nicol, Marie, Malbezin, Muriel, Olaiz, Javier, Rigaud-Bully, Claire, Debard, Nadine, Cotton, Sandra Vukusic François, Ionescu, Iuliana, Abdelalli, Amalle, Pelletier, Jean, Audoin, Bertrand, Maarouf, Adil, Di Lelio, Bernadette, Ayrignac, Xavier, Labauge, Pierre, Pinna, Frédéric, Guillemin, Francis, Debouverie, Marc, Ziegler, Amandine, Wiertlevski, Sandrine, Bresch, Saskia, Callier, Céline, David, Elodie, Castelnovo, Giovanni, Papeix, Caroline, Maillart, Elisabeth, Lubetzki, Catherine, Zehrouni, Karima, Fontaine, Bertrand, Giannesini, Claire, Hodel, Jérôme, Wahab, Abir, Zedet, Mickaël, Fagniez, Ombeline, Laage, Clémence, Pottier, Corinne, Slesari, Iuliana, Sampaio, Mathilde, Rabois, Emilie, Castex, Cédric, Hebant, Benjamin, Guillaume, Maxime, Vimont, Christine, Gout, Olivier, Guegen, Antoine, Michel, Laure, Muraz, Romain, Le Port, Damien, Leray, Emmanuelle, Henry, Carole, de Broucker, Thomas, Collongues, Nicolas, Berthe, Carole, Biotti, Damien, Freitas, Noellie, Visneux, Vincent, Forestier, Mélanie, Beltran, Stéphane, Meunier, Géraldine, Servan, Jérôme, Pico, Fernando, Chatagner, Virginie, Radji, Fatai, Morel, Nathalie, Grosset-Jeannin, Deborah, Ungureanu, Aurelian, Boyer, Latine, Suchet, Laurent, Lebrun-Frenay, Christine, Centre Hospitalier Universitaire de Nice (CHU Nice), Université Côte d'Azur (UCA), Unité de Recherche Clinique de la Côte d’Azur (URRIS UR2CA), Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), University of Texas Southwestern Medical Center [Dallas], Cerrahpasa Faculty of Medicine, Istanbul University, University of Southern California (USC), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Lille, Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CIC Plurithématique de Nantes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Ministère des Affaires sociales et de la Santé-Direction générale de l'offre de soins (DGOS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Translational Research in Autoimmunity and Inflammation Group (TIMC-T-RAIG), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), CHU Strasbourg, CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Mayo Clinic [Rochester], Yale School of Medicine [New Haven, Connecticut] (YSM), Service de Neurologie [CHU Nimes] (Pôle NIRR), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and None

Subjects
[SCCO.NEUR]Cognitive science/Neuroscience, diagnostic criteria, radiologically isolated syndrome, Neurology (clinical), prognosis, multiple sclerosis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MRI
Abstract

The radiologically isolated syndrome (RIS) was defined in 2009 as the presence of asymptomatic, incidentally identified demyelinating-appearing white matter lesions in the CNS within individuals lacking symptoms typical of multiple sclerosis (MS). The RIS criteria have been validated and predict the transition to symptomatic MS reliably. The performance of RIS criteria that require fewer MRI lesions is unknown. 2009-RIS subjects, by definition, fulfil three to four of four criteria for 2005 dissemination in space (DIS) and subjects fulfilling only one or two lesions in at least one 2017 DIS location were identified within 37 prospective databases. Univariate and multivariate Cox regression models were used to identify predictors of a first clinical event. Performances of different groups were calculated. Seven hundred and forty-seven subjects (72.2% female, mean age 37.7 ± 12.3 years at the index MRI) were included. The mean clinical follow-up time was 46.8 ± 45.4 months. All subjects had focal T2 hyperintensities suggestive of inflammatory demyelination on MRI; 251 (33.6%) fulfilled one or two 2017 DIS criteria (designated as Groups 1 and 2, respectively), and 496 (66.4%) fulfilled three or four 2005 DIS criteria representing 2009-RIS subjects. Group 1 and 2 subjects were younger than the 2009-RIS group and were more likely to develop new T2 lesions over time (P < 0.001). Groups 1 and 2 were similar regarding survival distribution and risk factors for transition to MS. At 5 years, the cumulative probability for a clinical event was 29.0% for Groups 1 and 2 compared to 38.7% for 2009-RIS (P = 0.0241). The presence of spinal cord lesions on the index scan and CSF-restricted oligoclonal bands in Groups 1–2 increased the risk of symptomatic MS evolution at 5 years to 38%, comparable to the risk of development in the 2009-RIS group. The presence of new T2 or gadolinium-enhancing lesions on follow-up scans independently increased the risk of presenting with a clinical event (P < 0.001). The 2009-RIS subjects or Groups 1 and 2 with at least two of the risk factors for a clinical event demonstrated better sensitivity (86.0%), negative predictive value (73.1%), accuracy (59.8%) and area under the curve (60.7%) compared to other criteria studied. This large prospective cohort brings Class I evidence that subjects with fewer lesions than required in the 2009 RIS criteria evolve directly to a first clinical event at a similar rate when additional risk factors are present. Our results provide a rationale for revisions to existing RIS diagnostic criteria.

Published
2023

23. B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins

Author

Guthmiller, Jenna, primary, Lan, Linda Yu-Ling, additional, Li, Lei, additional, Henry, Carole, additional, Stamper, Christopher, additional, Utset, Henry, additional, Freyn, Alec, additional, Han, Julianna, additional, Stovicek, Olivia, additional, Wang, Jiaolong, additional, Zheng, Nai-Ying, additional, Huang, Min, additional, Dugan, Haley, additional, Tepora, Micah, additional, Zhu, Xueyong, additional, Chen, Yao-Qing, additional, Palm, Anna-Karin, additional, Shaw, Dustin, additional, Loganathan, Madhumanthi, additional, Francis, Benjamin, additional, McNair, Mia, additional, Mead, Philip, additional, Wilson, Ian, additional, Garcia-Sastre, Adolfo, additional, Nachbagauer, Raffael, additional, Palese, Peter, additional, Ward, Andrew, additional, Coughlan, Lynda, additional, Krammer, Florian, additional, and Wilson, Patrick, additional

Published
2023
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24. Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice

Author

Garcia-Dominguez, Dario, primary, Henry, Carole, additional, Ma, LingZhi, additional, Jani, Hardik, additional, Amato, Nicholas J., additional, Manning, Taylor, additional, Freyn, Alec, additional, Davis, Heather, additional, Hsiao, Chiaowen Joyce, additional, Li, Mengying, additional, Koch, Hillary, additional, Elbashir, Sayda, additional, DiPiazza, Anthony, additional, Carfi, Andrea, additional, Edwards, Darin, additional, and Bahl, Kapil, additional

Published
2022
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25. Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

Author

Stewart-Jones, Guillaume B.E., primary, Elbashir, Sayda M., additional, Wu, Kai, additional, Lee, Diana, additional, Renzi, Isabella, additional, Ying, Baoling, additional, Koch, Matthew, additional, Sein, Caralyn E., additional, Choi, Angela, additional, Whitener, Bradley, additional, Garcia-Dominguez, Dario, additional, Henry, Carole, additional, Woods, Angela, additional, Ma, LingZhi, additional, Montes Berrueta, Daniela, additional, Avena, Laura E., additional, Quinones, Julian, additional, Falcone, Samantha, additional, Hsiao, Chiaowen J., additional, Scheaffer, Suzanne M., additional, Thackray, Larissa B., additional, White, Phil, additional, Diamond, Michael S., additional, Edwards, Darin K., additional, and Carfi, Andrea, additional

Published
2022
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28. Prospective Characterization of Brain T2 Lesions Suggestive of Demyelination in Asymptomatic Patients diagnosed as Radiologically Isolated Syndrome (P14-4.011)

Author

Landes-Château, Cassandre, primary, Mondot, Lydiane, additional, Cohen, Mikael, additional, Callier, Céline, additional, Zephir, Helene, additional, Louapre, Celine, additional, Dubief, Francoise Durand, additional, Carra-Dalliere, Clarisse, additional, Thouvenot, Eric, additional, Le Page, Emmanuelle, additional, Ruet, Aurelie, additional, Berger, Eric, additional, Derache, Nathalie, additional, Clavelou, Pierre, additional, Moreau, Thibault, additional, Casez, Olivier, additional, Gout, Olivier, additional, De Seze, Jerome, additional, Ciron, Jonathan, additional, Wiertlewski, Sandrine, additional, Bourre, Bertrand, additional, Magy, Laurent, additional, Cabre, Philippe, additional, Pelletier, Jean, additional, Debouverie, Marc, additional, Stankoff, Bruno, additional, Creange, Alain, additional, Fagniez, Ombeline, additional, Pottier, Corinne, additional, Neau, Jean Philippe, additional, Camdessanche, Jean-Philippe, additional, Henry, Carole, additional, Beltran, Stephane, additional, Guennoc, Anne Marie, additional, Tourbah, Ayman, additional, Radji, Fatai, additional, Morel, Nathalie, additional, Boyer, Karine, additional, Al Khedr, Abdullatif, additional, Siva, Aksel, additional, Kantarci, Orhun, additional, Pelletier, Daniel, additional, Okuda, Darin, additional, and Lebrun-Frenay, Christine, additional

Published
2022
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29. B cell convergence to distinct broadly reactive epitopes revealed by chimeric hemagglutinin vaccination

Author

Guthmiller, Jenna, primary, Li, Lei, additional, Lan, Linda Yu-Ling, additional, Henry, Carole, additional, Stamper, Christopher, additional, Freyn, Alec, additional, Utset, Henry, additional, Han, Julianna, additional, Palese, Peter, additional, Coughlan, Lynda, additional, Ward, Andrew, additional, Krammer, Florian, additional, and Wilson, Patrick C, additional

Published
2022
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30. Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Author

Guthmiller, Jenna J., primary, Han, Julianna, additional, Utset, Henry A., additional, Li, Lei, additional, Lan, Linda Yu-Ling, additional, Henry, Carole, additional, Stamper, Christopher T., additional, McMahon, Meagan, additional, O’Dell, George, additional, Fernández-Quintero, Monica L., additional, Freyn, Alec W., additional, Amanat, Fatima, additional, Stovicek, Olivia, additional, Gentles, Lauren, additional, Richey, Sara T., additional, de la Peña, Alba Torrents, additional, Rosado, Victoria, additional, Dugan, Haley L., additional, Zheng, Nai-Ying, additional, Tepora, Micah E., additional, Bitar, Dalia J., additional, Changrob, Siriruk, additional, Strohmeier, Shirin, additional, Huang, Min, additional, García-Sastre, Adolfo, additional, Liedl, Klaus R., additional, Bloom, Jesse D., additional, Nachbagauer, Raffael, additional, Palese, Peter, additional, Krammer, Florian, additional, Coughlan, Lynda, additional, Ward, Andrew B., additional, and Wilson, Patrick C., additional

Published
2021
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31. Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

Author

Wu, Kai, primary, Choi, Angela, additional, Koch, Matthew, additional, Elbashir, Sayda, additional, Ma, LingZhi, additional, Lee, Diana, additional, Woods, Angela, additional, Henry, Carole, additional, Palandjian, Charis, additional, Hill, Anna, additional, Jani, Hardik, additional, Quinones, Julian, additional, Nunna, Naveen, additional, O'Connell, Sarah, additional, McDermott, Adrian B., additional, Falcone, Samantha, additional, Narayanan, Elisabeth, additional, Colpitts, Tonya, additional, Bennett, Hamilton, additional, Corbett, Kizzmekia S., additional, Seder, Robert, additional, Graham, Barney S., additional, Stewart-Jones, Guillaume B.E., additional, Carfi, Andrea, additional, and Edwards, Darin K., additional

Published
2021
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32. An Egg-Derived Sulfated N -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines

Author

Guthmiller, Jenna J., primary, Utset, Henry A., additional, Henry, Carole, additional, Li, Lei, additional, Zheng, Nai-Ying, additional, Sun, Weina, additional, Costa Vieira, Marcos, additional, Zost, Seth, additional, Huang, Min, additional, Hensley, Scott E., additional, Cobey, Sarah, additional, Palese, Peter, additional, and Wilson, Patrick C., additional

Published
2021
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33. Neurologic manifestations associated with COVID-19: a multicentre registry

Author

Meppiel, Elodie, primary, Peiffer-Smadja, Nathan, additional, Maury, Alexandra, additional, Bekri, Imen, additional, Delorme, Cécile, additional, Desestret, Virginie, additional, Gorza, Lucas, additional, Hautecloque-Raysz, Geoffroy, additional, Landre, Sophie, additional, Lannuzel, Annie, additional, Moulin, Solène, additional, Perrin, Peggy, additional, Petitgas, Paul, additional, SellaI, François, additional, Wang, Adrien, additional, Tattevin, Pierre, additional, de Broucker, Thomas, additional, Abgrall, Sophie, additional, Alby-Laurent, Fanny, additional, Allou, Thibault, additional, Amevigbe, Joséphine, additional, Amarguellay, Hanifa, additional, Alloussi, Nabil, additional, Baille, Guillaume, additional, Barbaz, Mathilde, additional, Bencherif, Lamia, additional, Bensaadi, Samia, additional, Beraud, Guillaume, additional, Bizot, Alexandra, additional, Bottin, Laure, additional, Bruneel, Fabrice, additional, Camdessanche, Jean-Philippe, additional, Chauffier, Jeanne, additional, Csajaghy, Jean-Philippe, additional, De Broucker, Chloé, additional, De Broucker, Thomas, additional, Defebvre, Luc, additional, Dembloque, Elodie, additional, Derache, Nathalie, additional, Dereeper, Olivier, additional, Derollez, Céline, additional, Descotes-Genon, Cécile, additional, Devaux, Mathilde, additional, Dubuc, Lydie, additional, Edan, Gilles, additional, Fickl, Andréa, additional, Fraisse, Thibault, additional, Gugenheim, Michel, additional, Hankiewicz, Karolina, additional, Hansmann, Yves, additional, Henry, Carole, additional, Jobard, Stéphanie, additional, Jouan, Fanny, additional, Kwiatkowski, Arnaud, additional, Lalu, Thibault, additional, Leguilloux, Johan, additional, Lejeune, Camille, additional, Liegeois, Clémence, additional, Mahy, Sophie, additional, Marey, Jonathan, additional, Meppiel, Elodie, additional, Michel, Laure, additional, Mitri, Rita, additional, Moulin, Chloé, additional, Omarjee, Asma, additional, Ozsancak, Canan, additional, Pico, Fernando, additional, Poupard, Marie, additional, Rabier, Valérie, additional, Rizzato, Camille, additional, Roos, Caroline, additional, Saison, Julien, additional, Sayre, Naomi, additional, Sedillot, Nicolas, additional, Sellal, François, additional, Servan, Jérôme, additional, Storey, Caroline, additional, Suchet, Laurent, additional, Tarteret, Paul, additional, Thiebaut, Mathilde, additional, Vaduva, Claudia, additional, Varlan, David, additional, and Zarrouk, Virginie, additional

Published
2021
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34. A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

Author

Guthmiller, Jenna J., primary, Han, Julianna, additional, Utset, Henry A., additional, Li, Lei, additional, Lan, Linda Yu-Ling, additional, Henry, Carole, additional, Stamper, Christopher T., additional, Stovicek, Olivia, additional, Gentles, Lauren, additional, Dugan, Haley L., additional, Zheng, Nai-Ying, additional, Richey, Sara T., additional, Tepora, Micah E., additional, Bitar, Dalia J., additional, Changrob, Siriruk, additional, Strohmeier, Shirin, additional, Huang, Min, additional, García-Sastre, Adolfo, additional, Nachbagauer, Raffael, additional, Palese, Peter, additional, Bloom, Jesse D., additional, Krammer, Florian, additional, Coughlan, Lynda, additional, Ward, Andrew B., additional, and Wilson, Patrick C., additional

Published
2021
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35. mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

Author

Meyer, Michelle, primary, Wang, Yuan, additional, Edwards, Darin, additional, Smith, Gregory R., additional, Rubenstein, Aliza B., additional, Ramanathan, Palaniappan, additional, Mire, Chad E., additional, Pietzsch, Colette, additional, Chen, Xi, additional, Ge, Yongchao, additional, Cheng, Wan Sze, additional, Henry, Carole, additional, Woods, Angela, additional, Ma, LingZhi, additional, Stewart-Jones, Guillaume B. E., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Periasamy, Sivakumar, additional, Shi, Pei-Yong, additional, Graham, Barney S., additional, Moore, Ian N., additional, Ramos, Irene, additional, Troyanskaya, Olga G., additional, Zaslavsky, Elena, additional, Carfi, Andrea, additional, Sealfon, Stuart C., additional, and Bukreyev, Alexander, additional

Published
2021
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36. Integration of Transcriptome and Cell Surface Protein Expression by LinQ-View Identifies Unique Immune Subpopulations

Author

Li, Lei, primary, Dugan, Haley L., additional, Stamper, Christopher, additional, Lan, Linda Yu-Ling, additional, Asby, Nicholas, additional, Knight, Matthew, additional, Stovicek, Olivia, additional, Zheng, Nai-Ying, additional, Madariaga, Maria Lucia, additional, Shanmugarajah, Kumaran, additional, Jansen, Maud O., additional, Changrob, Siriruk, additional, Utset, Henry A., additional, Henry, Carole, additional, Nelson, Christopher, additional, Jedrzejczak, Robert, additional, Fremont, Daved, additional, Joachimiak, Andrzej, additional, Krammer, Florian, additional, Huang, Jun, additional, Khan, Aly, additional, and Wilson, Patrick C., additional

Published
2021
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37. Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

Author

Dugan, Haley L., primary, Guthmiller, Jenna J., additional, Arevalo, Philip, additional, Huang, Min, additional, Chen, Yao-Qing, additional, Neu, Karlynn E., additional, Henry, Carole, additional, Zheng, Nai-Ying, additional, Lan, Linda Yu-Ling, additional, Tepora, Micah E., additional, Stovicek, Olivia, additional, Bitar, Dalia, additional, Palm, Anna-Karin E., additional, Stamper, Christopher T., additional, Changrob, Siriruk, additional, Utset, Henry A., additional, Coughlan, Lynda, additional, Krammer, Florian, additional, Cobey, Sarah, additional, and Wilson, Patrick C., additional

Published
2020
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38. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Author

Guthmiller, Jenna J., primary, Lan, Linda Yu-Ling, additional, Fernández-Quintero, Monica L., additional, Han, Julianna, additional, Utset, Henry A., additional, Bitar, Dalia J., additional, Hamel, Natalie J., additional, Stovicek, Olivia, additional, Li, Lei, additional, Tepora, Micah, additional, Henry, Carole, additional, Neu, Karlynn E., additional, Dugan, Haley L., additional, Borowska, Marta T., additional, Chen, Yao-Qing, additional, Liu, Sean T.H., additional, Stamper, Christopher T., additional, Zheng, Nai-Ying, additional, Huang, Min, additional, Palm, Anna-Karin E., additional, García-Sastre, Adolfo, additional, Nachbagauer, Raffael, additional, Palese, Peter, additional, Coughlan, Lynda, additional, Krammer, Florian, additional, Ward, Andrew B., additional, Liedl, Klaus R., additional, and Wilson, Patrick C., additional

Published
2020
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42. Understanding memory B cell responses to a chimeric-based universal influenza virus vaccine candidate

Author

Lan, Linda (Yu-Ling), primary, Li, Lei, additional, Huang, Min, additional, Henry, Carole, additional, Zheng, Nai-Ying, additional, Chen, Yao-Qing, additional, McNair, Mahalia, additional, Meade, Philip, additional, Guthmiller, Jenna, additional, Dugan, Haley, additional, Tepora, Micah, additional, Palm, Anna-Karin, additional, Shaw, Dustin, additional, Stamper, Christopher, additional, Khan, Aly Azeem, additional, Nachbagauer, Raffael, additional, García-Sastre, Adolfo, additional, Palese, Peter, additional, Krammer, Florian, additional, and Wilson, Patrick C, additional

Published
2020
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43. Characterizing Emerging Canine H3 Influenza Viruses

Author

Martinez-Sobrido, Luis, primary, Blanco-Lobo, Pilar, additional, Rodriguez, Laura, additional, Fitzgerald, Theresa, additional, Zhang, Hanyuan, additional, Nguyen, Phuong, additional, Anderson, Christopher S., additional, Holden-Wiltse, Jeanne, additional, Bandyopadhyay, Sanjukta, additional, Nogales, Aitor, additional, DeDiego, Marta L., additional, Wasik, Brian R., additional, Miller, Benjamin L., additional, Henry, Carole, additional, Wilson, Patrick C., additional, Sangster, Mark Y., additional, Treanor, John J., additional, Topham, David J., additional, Byrd-Leotis, Lauren, additional, Steinhauer, David A., additional, Cummings, Richard D., additional, Luczo, Jasmina M., additional, Tompkins, Stephen M., additional, Sakamoto, Kaori, additional, Jones, Cheryl A., additional, Steel, John, additional, Lowen, Anice C., additional, Danzy, Shamika, additional, Tao, Hui, additional, Fink, Ashley L., additional, Klein, Sabra L., additional, Wohlgemuth, Nicholas, additional, Fenstermacher, Katherine J., additional, el Najjar, Farah, additional, Pekosz, Andrew, additional, Sauer, Lauren, additional, Lewis, Mitra K., additional, Shaw-Saliba, Kathryn, additional, Rothman, Richard E., additional, Liu, Zhen-Ying, additional, Chen, Kuan-Fu, additional, Parrish, Colin R., additional, Voorhees, Ian E. H., additional, Kawaoka, Yoshihiro, additional, Neumann, Gabriele, additional, Chiba, Shiho, additional, Fan, Shufang, additional, Hatta, Masato, additional, Kong, Huihui, additional, Zhong, Gongxun, additional, Wang, Guojun, additional, Uccellini, Melissa B., additional, García-Sastre, Adolfo, additional, Perez, Daniel R., additional, Ferreri, Lucas M., additional, Herfst, Sander, additional, Richard, Mathilde, additional, Fouchier, Ron, additional, Burke, David, additional, Pattinson, David, additional, Smith, Derek J., additional, Meliopoulos, Victoria, additional, Freiden, Pamela, additional, Livingston, Brandi, additional, Sharp, Bridgett, additional, Cherry, Sean, additional, Dib, Juan Carlos, additional, Yang, Guohua, additional, Russell, Charles J., additional, Barman, Subrata, additional, Webby, Richard J., additional, Krauss, Scott, additional, Danner, Angela, additional, Woodard, Karlie, additional, Peiris, Malik, additional, Perera, R. A. P. M., additional, Chan, M. C. W., additional, Govorkova, Elena A., additional, Marathe, Bindumadhav M., additional, Pascua, Philippe N. Q., additional, Smith, Gavin, additional, Li, Yao-Tsun, additional, Thomas, Paul G., additional, and Schultz-Cherry, Stacey, additional

Published
2020
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46. Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study

Author

Henry, Carole, primary, Palm, Anna-Karin E., additional, Utset, Henry A., additional, Huang, Min, additional, Ho, Irvin Y., additional, Zheng, Nai-Ying, additional, Fitzgerald, Theresa, additional, Neu, Karlynn E., additional, Chen, Yao-Qing, additional, Krammer, Florian, additional, Treanor, John J., additional, Sant, Andrea J., additional, Topham, David J., additional, and Wilson, Patrick C., additional

Published
2019
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48. MSJ849511_supplemental_figure – Supplemental material for Frequency and characteristics of short versus longitudinally extensive myelitis in adults with MOG antibodies: A retrospective multicentric study

Author

Ciron, Jonathan, Cobo-Calvo, Alvaro, Audoin, Bertrand, Bourre, Bertrand, Brassat, David, Cohen, Mikael, Collongues, Nicolas, Deschamps, Romain, Durand-Dubief, Françoise, Laplaud, David, Maillart, Elisabeth, Papeix, Caroline, Zephir, Hélène, Bereau, Matthieu, Brochet, Bruno, Carra-Dallière, Clarisse, Derache, Nathalie, Gagou-Scherer, Clarisse, Henry, Carole, Kerschen, Philippe, Mathey, Guillaume, Maubeuge, Nicolas, Maurousset, Aude, Montcuquet, Alexis, Moreau, Thibault, Prat, Christophe, Taithe, Frédéric, Thouvenot, Eric, Tourbah, Ayman, Rollot, Fabien, Vukusic, Sandra, and Marignier, Romain

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ849511_supplemental_figure for Frequency and characteristics of short versus longitudinally extensive myelitis in adults with MOG antibodies: A retrospective multicentric study by Jonathan Ciron, Alvaro Cobo-Calvo, Bertrand Audoin, Bertrand Bourre, David Brassat, Mikael Cohen, Nicolas Collongues, Romain Deschamps, Françoise Durand-Dubief, David Laplaud, Elisabeth Maillart, Caroline Papeix, Hélène Zephir, Matthieu Bereau, Bruno Brochet, Clarisse Carra-Dallière, Nathalie Derache, Clarisse Gagou-Scherer, Carole Henry, Philippe Kerschen, Guillaume Mathey, Nicolas Maubeuge, Aude Maurousset, Alexis Montcuquet, Thibault Moreau, Christophe Prat, Frédéric Taithe, Eric Thouvenot, Ayman Tourbah, Fabien Rollot, Sandra Vukusic and and Romain Marignier in Multiple Sclerosis Journal

Published
2019
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50. Frequency and characteristics of short versus longitudinally extensive myelitis in adults with MOG antibodies: A retrospective multicentric study

Author

Ciron, Jonathan, primary, Cobo-Calvo, Alvaro, additional, Audoin, Bertrand, additional, Bourre, Bertrand, additional, Brassat, David, additional, Cohen, Mikael, additional, Collongues, Nicolas, additional, Deschamps, Romain, additional, Durand-Dubief, Françoise, additional, Laplaud, David, additional, Maillart, Elisabeth, additional, Papeix, Caroline, additional, Zephir, Hélène, additional, Bereau, Matthieu, additional, Brochet, Bruno, additional, Carra-Dallière, Clarisse, additional, Derache, Nathalie, additional, Gagou-Scherer, Clarisse, additional, Henry, Carole, additional, Kerschen, Philippe, additional, Mathey, Guillaume, additional, Maubeuge, Nicolas, additional, Maurousset, Aude, additional, Montcuquet, Alexis, additional, Moreau, Thibault, additional, Prat, Christophe, additional, Taithe, Frédéric, additional, Thouvenot, Eric, additional, Tourbah, Ayman, additional, Rollot, Fabien, additional, Vukusic, Sandra, additional, and Marignier, Romain, additional

Published
2019
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