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Additional file 1. Supplementary tables. Table S1. Donor characteristics. Table S2. Concatenated labels from Lausanne atlas for the regions of interest of this study. Table S3. Information on primary and secondary antibodies. Table S4. Correlations between pathological hallmarks. Table S5. Correlations of p-NfM/H immunoreactivity with pathology load in superficial (layer I-III) and deep cortical layers (layer IV-VI). Table S6. Correlations of NfL immunoreactivity with pathology load in superficial (layer I-III) and deep cortical layers (layer IV-VI). Table S7. Correlations of MRI-derived cortical thickness with neurofilaments immunoreactivity and pathology load. Table S8. Correlations of DTI-derived cortical MD with neurofilaments immunoreactivity and pathology load.

Additional file 2. Supplementary figures. Fig. S1. Segmentation of entorhinal cortex, parahippocampal and fusiform gyrus in hippocampal section. Fig. S2. Quantification of pathology load using QuPath algorithms. Fig. S3. Photographs of representative sections of controls, PD and PDD/DLB donors stained for NfL and p-NfM/H. Fig. S4. Cortical pathology load in controls, PD and PDD/DLB donors. Fig. S5. Differences in cortical neurofilaments immunoreactivity in sex, and neurofilaments association with age. Fig. S6. Cortical neurofilaments immunoreactivity in superficial (layer I-III) and deep cortical layers (layer IV-VI). Fig. S7. Cortical neurofilaments correlation in superficial (layer I-III) and deep cortical layers (layer IV-VI). Fig. S8. Neurofilaments immunoreactivity in the parahippocampal gyrus correlates with pathological staging. Fig. S9. Cortical thickness and MD do not differ between controls, PD and PDD/DLB donors. Fig. S10. Cortical MD, but not cortical thickness, correlates with pSer129-αSyn and p-tau pathology.