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1. Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients

Author

Ferraz-Amaro, Iván, Genre, Fernanda, Blanco, Ricardo, Corrales, Alfonso, Mazón, Iñigo González, Portilla, Virginia, Aurrecoechea, Elena, Mata, Cristina, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez-Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, M. Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Vivar, María Luz García, Galíndez-Agirregoikoa, Eva, Vegas-Revenga, Nuria, Urionagüena-Onaindia, Irati, Perez, Esther Montes, Díaz, Carlos Fernández, González-Gay, Miguel Ángel, and Rueda-Gotor, Javier

Published
2023
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2. Cardiovascular and disease-related features associated with extra-articular manifestations in axial spondyloarthritis. A multicenter study of 888 patients

Author

Rueda-Gotor, Javier, Ferraz-Amaro, Iván, Genre, Fernanda, González Mazón, Iñigo, Corrales, Alfonso, Portilla, Virginia, Llorca, Javier, Agudo-Bilbao, Mario, Aurrecoechea, Elena, Expósito, Rosa, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez-Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, M Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Vivar, María Luz García, Galíndez-Agirregoikoa, Eva, Perez, Esther Montes, Fernández Díaz, Carlos, Blanco, Ricardo, and González-Gay, Miguel Ángel

Published
2022
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3. Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients

Author

Rueda-Gotor, Javier, Ferraz-Amaro, Iván, Genre, Fernanda, González-Mazón, Iñigo, Corrales, Alfonso, Calvo-Rio, Vanesa, Portilla, Virginia, Llorca, Javier, Expósito, Rosa, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez-Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, M Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, García-Vivar, María Luz, Galíndez-Agirregoikoa, Eva, Montes-Perez, Esther, Fernández-Díaz, Carlos, Blanco, Ricardo, and González-Gay, Miguel Ángel

Published
2022
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6. Subclinical atherosclerotic disease in ankylosing spondylitis and non-radiographic axial spondyloarthritis. A multicenter study on 806 patients

Author

González Mazón, Iñigo, Rueda-Gotor, Javier, Ferraz-Amaro, Iván, Genre, Fernanda, Corrales, Alfonso, Calvo Rio, Vanesa, Palmou Fontana, Natalia, Portilla, Virginia, Llorca, Javier, Mata, Cristina, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, García-Vivar, María Luz, Galíndez-Agirregoikoa, Eva, Montes Perez, Esther, Fernández Díaz, Carlos, Blanco, Ricardo, and González-Gay, Miguel Angel

Published
2021
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7. Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study

Author

Rueda-Gotor, Javier, López-Mejías, Raquel, Remuzgo-Martínez, Sara, Pulito-Cueto, Verónica, Corrales, Alfonso, Lera-Gómez, Leticia, Portilla, Virginia, González-Mazón, Íñigo, Blanco, Ricardo, Expósito, Rosa, Mata, Cristina, Llorca, Javier, Hernández-Hernández, Vanesa, Rodríguez-Lozano, Carlos, Barbarroja, Nuria, Castro, Rafaela Ortega, Vicente, Esther, Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Galíndez-Agirregoikoa, Eva, García-Vivar, María Luz, Gualillo, Oreste, Quevedo-Abeledo, Juan Carlos, Castañeda, Santos, Ferraz-Amaro, Iván, González-Gay, Miguel Á., and Genre, Fernanda

Published
2021
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9. Sex-specific impact of inflammation on traditional cardiovascular risk factors and atherosclerosis in axial spondyloarthritis. A multicentre study of 913 patients.

Author

Ferraz-Amaro, Ivan, Genre, Fernanda, Blanco, Ricardo, Calvo-Rio, Vanesa, Corrales-Selaya, Cristina, Portilla, Virginia, Aurrecoechea, Elena, Batanero, Ricardo, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, López-Medina, Clementina, Ladehesa-Pineda, Lourdes, Castañeda, Santos, Vicente-Rabaneda, Esther F., Fernández-Carballido, Cristina, Vidal, María Paz Martínez, Corredor, David Castro, Fernández, Joaquín Anino, and Peiteado, Diana

Published
2024
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12. Irisin as a Novel Biomarker of Subclinical Atherosclerosis, Cardiovascular Risk and Severe Disease in Axial Spondyloarthritis

Author

Remuzgo-Martínez, Sara, primary, Rueda-Gotor, Javier, additional, Pulito-Cueto, Verónica, additional, López-Mejías, Raquel, additional, Corrales, Alfonso, additional, Lera-Gómez, Leticia, additional, Pérez-Fernández, Raquel, additional, Portilla, Virginia, additional, González-Mazón, Íñigo, additional, Blanco, Ricardo, additional, Expósito, Rosa, additional, Mata, Cristina, additional, Llorca, Javier, additional, Hernández-Hernández, Vanesa, additional, Rodríguez-Lozano, Carlos, additional, Barbarroja, Nuria, additional, Ortega-Castro, Rafaela, additional, Vicente, Esther, additional, Fernández-Carballido, Cristina, additional, Martínez-Vidal, María Paz, additional, Castro-Corredor, David, additional, Anino-Fernández, Joaquín, additional, Peiteado, Diana, additional, Plasencia-Rodríguez, Chamaida, additional, Galíndez-Agirregoikoa, Eva, additional, García-Vivar, María Luz, additional, Vegas-Revenga, Nuria, additional, Urionaguena, Irati, additional, Gualillo, Oreste, additional, Quevedo-Abeledo, Juan Carlos, additional, Castañeda, Santos, additional, Ferraz-Amaro, Iván, additional, González-Gay, Miguel Á., additional, and Genre, Fernanda, additional

Published
2022
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13. Additional file 1 of HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis

Author

Ferraz-Amaro, Iván, Delgado-Frías, Esmeralda, Hernández-Hernández, Vanesa, Hiurma Sánchez-Pérez, Armas-Rillo, Laura De, Estefanía Armas-González, Machado, José David, and Diaz-González, Federico

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 1: Supplementary Figure 1. Multivariable analysis of the differences between scleroderma patients and controls in main lipid profile-related molecules (total cholesterol, triglycerides, HDL-cholesterol, apolipoprotein B and lipoprotein -mg/dl-, and cholesterol efflux capacity -%-).

Published
2021
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14. Additional file 2 of HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis

Author

Ferraz-Amaro, Iván, Delgado-Frías, Esmeralda, Hernández-Hernández, Vanesa, Hiurma Sánchez-Pérez, Armas-Rillo, Laura De, Estefanía Armas-González, Machado, José David, and Diaz-González, Federico

Abstract

Additional file 2: Supplementary Table 1. Differences in cardiovascular risk factors, lipid profiles and disease-related data between SS types.

Published
2021
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15. Additional file 1 of Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study

Author

Rueda-Gotor, Javier, López-Mejías, Raquel, Remuzgo-Martínez, Sara, Pulito-Cueto, Verónica, Corrales, Alfonso, Lera-Gómez, Leticia, Portilla, Virginia, González-Mazón, Íñigo, Blanco, Ricardo, Expósito, Rosa, Mata, Cristina, Llorca, Javier, Hernández-Hernández, Vanesa, Rodríguez-Lozano, Carlos, Barbarroja, Nuria, Castro, Rafaela Ortega, Vicente, Esther, Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Chamaida Plasencia-Rodríguez, Galíndez-Agirregoikoa, Eva, García-Vivar, María Luz, Gualillo, Oreste, Quevedo-Abeledo, Juan Carlos, Castañeda, Santos, Ferraz-Amaro, Iván, González-Gay, Miguel Á., and Genre, Fernanda

Abstract

Additional file 1: Supplementary Table 1. Demographic, clinical, laboratory, and cardiovascular disease-related characteristics in patients with axial spondyloarthritis carrying or not the A allele of vaspin rs7159023.

Published
2021
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18. Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Author

Genre, Fernanda, primary, Rueda-Gotor, Javier, additional, Remuzgo-Martínez, Sara, additional, Pulito-Cueto, Verónica, additional, Corrales, Alfonso, additional, Mijares, Verónica, additional, Lera-Gómez, Leticia, additional, Portilla, Virginia, additional, Expósito, Rosa, additional, Mata, Cristina, additional, Blanco, Ricardo, additional, Llorca, Javier, additional, Hernández-Hernández, Vanesa, additional, Vicente, Esther, additional, Fernández-Carballido, Cristina, additional, Martínez-Vidal, María Paz, additional, Castro-Corredor, David, additional, Anino-Fernández, Joaquín, additional, Rodríguez-Lozano, Carlos, additional, Gualillo, Oreste, additional, Quevedo-Abeledo, Juan Carlos, additional, Castañeda, Santos, additional, Ferraz-Amaro, Iván, additional, López-Mejías, Raquel, additional, and González-Gay, Miguel Á., additional

Published
2020
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19. Withdrawal of infliximab therapy in ankylosing spondylitis in persistent clinical remission, results from the REMINEA study

Author

Moreno Martínez-Losa, Mireia, Gratacós, Jordi, Torrente-Segarra, V., Sanmartí, Raimon, Morlà, R., Pontes, C., Llop, Maria, Juanola, Xavier, Rodriguez-De-La-Serna, A., Hernández Hernández, Vanesa, Riera, E., Ortiz, V., Clavaguera, T., Reyner, P., Sala, Miquel, Sellas, A., Pitarch, C., Reina, Delia, Blanco, J. (Joan), Centelles, M., Figuls, R., Gelman, M., Arasa, X., Bonet, Maria, Ciria, M., and Universitat Autònoma de Barcelona

Subjects
Adult, Male, 0301 basic medicine, musculoskeletal diseases, medicine.medical_specialty, Treatment withdrawal, lcsh:Diseases of the musculoskeletal system, Espondiloartritis anquilosant, Therapeutics, Severity of Illness Index, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Clinical trials, Recurrence, Internal medicine, medicine, Humans, Spondylitis, Ankylosing, Disease activity, BASDAI, HLA-B27 Antigen, 030203 arthritis & rheumatology, Ankylosing spondylitis, Tumor Necrosis Factor-alpha, business.industry, Remission Induction, Enthesitis, Anti-TNF therapy, Middle Aged, medicine.disease, Terapèutica, Infliximab, Rheumatology, Discontinuation, 030104 developmental biology, Withholding Treatment, Antirheumatic Agents, Cohort, Female, lcsh:RC925-935, medicine.symptom, BASFI, business, Research Article, medicine.drug, Assaigs clínics
Abstract

Altres ajuts: This work is conducted under the umbrella of the Rheumatology Society of Catalonia and supported by Merck Research Laboratories. Background: Recent data suggest that anti-TNF doses can be reduced in ankylosing spondylitis (AS) patients. Some authors even propose withdrawing treatment in patients in clinical remission; however, at present there is no evidence to support this. Objective: To assess how long AS patients with persistent clinical remission remained free of flares after anti-TNF withdrawal and to evaluate the effects of treatment reintroduction. We also analyze the characteristics of patients who did not present clinical relapse. Methods: Multicenter, prospective, observational study of a cohort of patients with active AS who had received infliximab as a first anti-TNF treatment and who presented persistent remission (more than 6 months). We recorded at baseline and every 6-8 weeks over the 12-month period the age, gender, disease duration, peripheral arthritis or enthesitis, HLA-B27 status, BASDAI, CRP, ESR, BASFI, and three visual analogue scales, spine global pain, spinal night time pain, and patient's global assessment. Results: Thirty-six out of 107 patients (34%) presented persistent remission and were included in our study. After treatment withdrawal, 21 of these 36 patients (58%) presented clinical relapse during follow-up. Infliximab therapy was reintroduced and only 52% achieved clinical remission, as they had before the discontinuation of infliximab; in an additional 10%, reintroduction of infliximab was ineffective, obliging us to change the anti-TNF therapy. No clinical or biological factors were associated with the occurrence of relapse during the follow-up. Conclusions: Two thirds of patients in clinical remission presented clinical relapse shortly after infliximab withdrawal. Although the reintroduction of infliximab treatment was safe, half of the patients did not present the same clinical response that they had achieved prior to treatment withdrawal.

Published
2019

20. Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis

Author

Armas-González, Estefanía, Domínguez-Luis, María Jesús, Díaz-Martín, Ana, Arce-Franco, Mayte, Castro-Hernández, Javier, Danelon, Gabriela, Hernández-Hernández, Vanesa, Bustabad-Reyes, Sagrario, Cantabrana, Alberto, Uguccioni, Díaz-González, Federico, Armas-González, Estefanía, Domínguez-Luis, María Jesús, Díaz-Martín, Ana, Arce-Franco, Mayte, Castro-Hernández, Javier, Danelon, Gabriela, Hernández-Hernández, Vanesa, Bustabad-Reyes, Sagrario, Cantabrana, Alberto, Uguccioni, and Díaz-González, Federico

Abstract

Background: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed synovium, taking into account that the rich chemokine milieu present in the synovial tissue can fine-tune modulate discrete chemokine receptors. Methods: Expression levels of chemokine receptors from the CC and CXC family, as well as CD27, were assessed by flow cytometry in CD20+ mononuclear cells isolated from the peripheral blood (PB) and synovial fluid (SF) of RA and psoriatic arthritis patients. Transwell experiments were used to study migration of B cells in response to a chemokine or in the presence of multiple chemokines. Results: B cells from the SF of arthritis patients showed a significant increase in the surface expression of CCR1, CCR2, CCR4, CCR5 and CXCR4 with respect to PB. Conversely, SF B cells expressed consistently lower amounts of CXCR5, CXCR7 and CCR6, independent of CD27 expression. Analysis of permeabilized B cells suggested internalization of CXCR5 and CCR6 in SF B cells. In Transwell experiments, CCL20 and CXCL13, ligands of CCR6 and CXCR5, respectively, caused a significantly higher migration of B cells from PB than of those from SF of RA patients. Together, these two chemokines synergistically increased B-cell migration from PB, but not from SF. Conclusions: These results suggest that CXCL13 and CCL20 might play major roles in RA pathogenesis by acting singly on their selective receptors and synergistically in the accumulation of B cells within the inflamed synovium.

Published
2019

21. Circulating interleukin-6 and cardiovascular disease risk in patients with rheumatoid arthritis with low disease activity due to active therapy.

Author

Almeida-Santiago C, Quevedo-Abeledo JC, Hernández-Hernández V, de Vera-González A, González-Delgado A, González-Gay MÁ, and Ferraz-Amaro I

Subjects
Humans, Interleukin-6, Risk Factors, Cross-Sectional Studies, Carotid Intima-Media Thickness, Acute-Phase Proteins, Lipids, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Insulin Resistance, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid drug therapy, Carotid Artery Diseases etiology, Carotid Artery Diseases complications
Abstract

Objectives: Interleukin-6 (IL-6) has been implicated in the pathophysiology of rheumatoid arthritis (RA) and in the development of atherosclerosis in the general population. In the present work we aimed to study if IL-6 serum levels have an influence on factors associated with cardiovascular (CV) disease in a cohort of Spanish patients with RA., Methods: Cross-sectional study that encompassed 407 patients with RA. Serum IL-6 levels were assessed. Multivariable analysis was performed to examine the relationship of IL-6 to subclinical carotid atherosclerosis and classic CV risk factors, including a comprehensive lipid molecule profile and indices of insulin resistance and beta-cell function., Results: Circulating levels of IL-6 showed a correlation with acute phase reactants, disease activity, and other features of RA. However, classic CV risk factors, lipid profile and indices of insulin resistance, as well as subclinical carotid atherosclerosis, were not associated with serum IL-6 levels., Conclusions: Although a direct association between IL-6 levels and traditional CV risk factors and subclinical carotid atherosclerosis was not observed, circulating IL-6 was associated with disease activity and acute-phase reactants, which have been associated with an increased risk of CV in these patients.

Published
2023
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22. Reclassification into very-high cardiovascular risk after carotid ultrasound in patients with axial spondyloarthritis.

Author

Rueda-Gotor J, Quevedo-Abeledo JC, Corrales A, Genre F, Hernández-Hernández V, Delgado-Frías E, González-Gay MÁ, and Ferraz-Amaro I

Subjects
Carotid Intima-Media Thickness, Humans, Risk Factors, Ultrasonography, Cardiovascular Diseases, Spondylarthritis
Abstract

Objectives: Subclinical atherosclerosis, defined as the presence of carotid plaques, is more frequently found in patients with axial spondyloarthritis (axSpA) than in healthy individuals. We sought to determine whether axSpA patients are more commonly reclassified into the very high cardiovascular risk category than controls after performing carotid ultrasound and if this can be linked to disease characteristics., Methods: 343 patients diagnosed with axSpA according to ASAS criteria and 177 controls were studied. Disease characteristics and Systematic Coronary Risk Evaluation (SCORE) were assessed in patients and controls. Presence of plaques and intima-media thickness (cIMT) was determined by carotid ultrasound. Multivariable regression analysis was performed to identify differences in the frequency of reclassification between patients and controls, as well as factors associated with reclassification in axSpA., Results: Carotid plaques (36% vs.25%, p=0.010) and higher cIMT (0.641± 0.121 vs. 0.602± 0.115 mm, p=0.001) were more common in patients than controls. Reclassification into the high-risk category was greater in patients (34% vs. 25%, p=0.037). Age (beta coefficient 2.74 [95%CI 1.34-5.62] vs. beta coef. 0.63 (95%CI 0.40-0.99) in patients, interaction p=0.001) and serum LDL-cholesterol (beta coef. 1.03 [95%CI 1.02-1.04] vs. beta coef. 1.00 [0.99-1.01], interaction p=0.029) showed a higher effect on reclassification in controls after multivariable analysis. Although reclassification in axSpA was associated with higher ASDAS-CRP, BASFI and BASMI scores, these associations were lost after adjusting for cardiovascular risk factors., Conclusions: Patients with axSpA are more likely to be reclassified into the very-high risk category after carotid ultrasound than controls. The influence of traditional cardiovascular risk factors on this reclassification differs between patients and controls.

Published
2020

23. Proprotein convertase subtilisin/kexin type 9 in patients with systemic sclerosis.

Author

Ferraz-Amaro I, Delgado-Frías E, Hernández-Hernández V, Sánchez-Pérez H, de Armas-Rillo L, García-Dopico JA, and Díaz-González F

Subjects
Carotid Intima-Media Thickness, Cross-Sectional Studies, Humans, Subtilisins, Proprotein Convertase 9, Scleroderma, Systemic
Abstract

Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that regulates cholesterol metabolism through low-density lipoprotein receptor degradation, and which has been linked to cardiovascular risk. The purpose of the present study was to examine whether PCSK9 serum levels are disrupted in patients with systemic sclerosis (SS) compared to controls, and if PCSK9 is related to disease-related data and the subclinical atherosclerosis that occurs in these patients., Methods: Cross-sectional study that encompassed 146 individuals; 73 patients with SS and 73 age- and sex-matched controls. PCSK9, lipoproteins serum concentrations, and standard lipid profiles were assessed in patients and controls. Carotid intima-media thickness (cIMT) and the presence of carotid plaques were evaluated in SS patients. A multivariable analysis, adjusted for traditional cardiovascular risk factors, was performed to evaluate the differences in PCSK9 between patients and controls, the association of SS-related manifestations with PCSK9 levels, and if PCSK9 was associated with subclinical carotid atherosclerosis in SS patients., Results: After multivariable analysis, PCSK9 was downregulated in SS patients compared to controls (beta coefficient -78 (95%CI -106 - -50) ng/ml, p=0.000) and skin thickness was associated with higher serum levels of PCSK9 (beta coef. 22 (7-37) units, p=0.005). PCSK9 was significantly and positively associated with cIMT (beta coef. 0.65 (0.06-1.24) ng/ml, p=0.031) in SS patients after multivariable adjustment., Conclusions: PCSK9 serum concentration is downregulated in SS patients compared to controls and is directly associated with disease severity subrogated parameters. PCSK9 was independently related to cIMT in SS patients.

Published
2020

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