Search

Your search keyword '"Higgins, Des"' showing total 8 results
Start Over Author "Higgins, Des" Publication Year Range Last 10 years
8 results on '"Higgins, Des"'

3. An Integrated Global Analysis of Compartmentalized HRAS Signaling

Author

Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Santra, Tapesh, Herrero, Ana, Rodriguez, Javier, von Kriegsheim, Alex, Iglesias-Martinez, Luis F, Schwarzl, Thomas, Higgins, Des, Aye, Thin-Thin, Heck, Albert J R, Calvo, Fernando, Agudo-Ibáñez, Lorena, Crespo, Piero, Matallanas, David, Kolch, Walter, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Santra, Tapesh, Herrero, Ana, Rodriguez, Javier, von Kriegsheim, Alex, Iglesias-Martinez, Luis F, Schwarzl, Thomas, Higgins, Des, Aye, Thin-Thin, Heck, Albert J R, Calvo, Fernando, Agudo-Ibáñez, Lorena, Crespo, Piero, Matallanas, David, and Kolch, Walter

Published
2019

4. An Integrated Global Analysis of Compartmentalized HRAS Signaling

Author

Science Foundation Ireland, Irish Cancer Society, European Commission, Netherlands Organization for Scientific Research, Centro de Investigación Biomédica en Red Cáncer (España), Asociación Española Contra el Cáncer, Santra, Tapesh, Herrero, Ana, Rodríguez, Javier, Kriegsheim, Alexvon, Iglesias-Martinez, Luis F., Schwarzl, Thomas, Higgins, Des, Aye, Thin-Thin, Heck, Albert J. R., Calvo, Fernando, Agudo-Ibáñez, Lorena, Crespo, Piero, Matallanas, David, Kolch, Walter, Science Foundation Ireland, Irish Cancer Society, European Commission, Netherlands Organization for Scientific Research, Centro de Investigación Biomédica en Red Cáncer (España), Asociación Española Contra el Cáncer, Santra, Tapesh, Herrero, Ana, Rodríguez, Javier, Kriegsheim, Alexvon, Iglesias-Martinez, Luis F., Schwarzl, Thomas, Higgins, Des, Aye, Thin-Thin, Heck, Albert J. R., Calvo, Fernando, Agudo-Ibáñez, Lorena, Crespo, Piero, Matallanas, David, and Kolch, Walter

Abstract

Modern omics technologies allow us to obtain global information on different types of biological networks. However, integrating these different types of analyses into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that integrates protein interaction, phosphoproteomics, and transcriptomics data. Applying this method to analyze HRAS signaling from different subcellular compartments shows that spatially defined networks contribute specific functions to HRAS signaling. Changes in HRAS protein interactions at different sites lead to different kinase activation patterns that differentially regulate gene transcription. HRASmediated signaling is the strongest from the cell membrane, but it regulates the largest number of genes from the endoplasmic reticulum. The integrated networks provide a topologically and functionally resolved view of HRAS signaling. They reveal distinct HRAS functions including the control of cell migration from the endoplasmic reticulum and TP53-dependent cell survival when signaling from the Golgi apparatus.

Published
2019

6. Abstract 2878: The tumor-permissive role of KHSRP in colorectal cancer: Mechanistic insights from a gene expression study

Author

Caiazza, Francesco, primary, Power, Robert, additional, Killick, Kate, additional, Higgins, Des, additional, Kolch, Walter, additional, Breen, Laura, additional, Aherne, Sinead, additional, Das, Sudipto, additional, O’Connor, Darran, additional, Tosetto, Miriam, additional, Nolan, Blathnaid, additional, Fennelly, David, additional, Sheahan, Kieran, additional, Doherty, Glen, additional, and Ryan, Elizabeth J., additional

Published
2016
Full Text
View/download PDF

7. Su2021 The Tumor-Permissive Role of KHSRP as a Target for the Polyphenol Resveratrol: Potential Tumor-Suppressive Effects in a Pre-Clinical Model of Colorectal Cancer

Author

Caiazza, Francesco, primary, Power, Robert P., additional, Killick, Kate, additional, Higgins, Des, additional, Kolch, Walter, additional, Breen, Laura, additional, Aherne, Sinead, additional, Das, Sudipto, additional, O'Connor, Darran, additional, Tosetto, Miriam, additional, Nolan, Blathnaid, additional, Fennelly, David, additional, Sheahan, Kieran, additional, Doherty, Glen A., additional, and Ryan, Elizabeth, additional

Published
2016
Full Text
View/download PDF

8. Artist says metal knot reflects Altoona, Midwest

Abstract

ALTOONA, Iowa (AP) ” The artist behind a unique new sculpture in Altoona says it reflects both the city™s tight-knit nature and a defining feature of the Midwest.Construction on œWoven Lines, a sculpture by artist Aaron T. Stephan of Portland, Maine, is well underway at the site of a new roundabout at 1st Avenue North and 9th Street Northwest. It™s made from 1,500 feet of metal guardrail that swoops into a 20,000-pound knot and will serve as an anchor of Altoona™s north side. [ABSTRACT FROM PUBLISHER]

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results