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6 results on '"Horimoto, Masao"'

1. 25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth

Author

Marx-Stoelting, Philip, Solano, Marize de L.M., Aoyama, Hiroaki, Adams, Ralf H., Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L., Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, and Solecki, Roland

Published
2021
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2. 25th anniversary of the Berlin Workshop on Developmental Toxicology:DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth

Author

Marx-Stoelting, Philip, Solano, Marize de L M, Aoyama, Hiroaki, Adams, Ralf H, Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L, Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, Solecki, Rol, Marx-Stoelting, Philip, Solano, Marize de L M, Aoyama, Hiroaki, Adams, Ralf H, Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L, Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, and Solecki, Rol

Abstract

25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together international experts from authorities, academia and industry to consider scientific, methodologic and regulatory aspects in risk assessment of developmental toxicity and to debate alternative strategies in testing developmental effects in the future. Proposals for improvement of the categorization of developmental effects were discussed as well as the update of the DevTox database as valuable tool for harmonization. The development of adverse outcome pathways relevant to developmental neurotoxicity (DNT) was debated as a fundamental improvement to guide the screening and testing for DNT using alternatives to animal methods. A further focus was the implementation of an in vitro mechanism-based battery, which can support various regulatory applications associated with the assessment of chemicals and mixtures. More interdisciplinary and translation research should be initiated to accelerate the development of new technologies to test developmental toxicity. Technologies in the pipeline are (i) high throughput imaging techniques, (ii) models for DNT screening tests, (iii) use of computer tomography for assessment of thoracolumbar supernumerary ribs in animal models, and (iv) 3D biofabrication of bone development and regeneration tissue models. In addition, increased collaboration with the medical community was suggested to improve the relevance of test results to humans and identify more clinically relevant endpoints. Finally, the participants agreed that this conference facilitated better understanding innovative approaches that can be useful for the identification of developmental health risks due to exposure to chemical substances.

Published
2021

3. Historical control data on developmental toxicity studies in rats

Author

Kuwagata, Makiko, primary, Sakai, Yuko, additional, Tanaka, Sho, additional, Takashima, Hiromasa, additional, Katagiri, Ryuichi, additional, Matsuoka, Toshiki, additional, Noritake, Kenichi, additional, Senuma, Mika, additional, Shimizu, Tatsuya, additional, Hojo, Hitoshi, additional, Ibi, Kanata, additional, Kudo, Satoshi, additional, Oota, Takafumi, additional, Ube, Masayuki, additional, Miwa, Yoji, additional, Kajita, Shimpei, additional, Uesugi, Tohru, additional, Yabe, Kaoru, additional, Tateishi, Taishi, additional, Nakano, Nao, additional, Taniguchi, Terumasa, additional, Yamashita, Akihito, additional, Hirano, Takayuki, additional, Kirihata, Yuka, additional, Sakai, Yumi, additional, Nishizawa, Shino, additional, Fujiwara, Michio, additional, Mineshima, Hiroshi, additional, Horimoto, Masao, additional, and Ema, Makoto, additional

Published
2018
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5. Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis.

Author

Fujii, Sakiko, Yabe, Kaoru, Kariwano‐Kimura, Yuki, Furukawa, Masatoshi, Itoh, Kouta, Matsuura, Masao, and Horimoto, Masao

Abstract

To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant Sprague Dawley (SD) rats in a single dose on day 11 of pregnancy at 25 or 35 mg/kg. Fetuses on day 20 of pregnancy were externally, viscerally, and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35 mg/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs. Our findings indicated that specific types of external and skeletal anomalies were induced following flucytosine administration on day 11 of pregnancy. [ABSTRACT FROM AUTHOR]

Published
2019
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6. Historical control data on developmental toxicity studies in rats.

Author

Kuwagata M, Sakai Y, Tanaka S, Takashima H, Katagiri R, Matsuoka T, Noritake K, Senuma M, Shimizu T, Hojo H, Ibi K, Kudo S, Oota T, Ube M, Miwa Y, Kajita S, Uesugi T, Yabe K, Tateishi T, Nakano N, Taniguchi T, Yamashita A, Hirano T, Kirihata Y, Sakai Y, Nishizawa S, Fujiwara M, Mineshima H, Horimoto M, and Ema M

Subjects
Animals, Disease Models, Animal, Female, Immunohistochemistry, Male, Phenotype, Pregnancy, Rats, Rats, Sprague-Dawley, Rats, Wistar, Reproducibility of Results, Developmental Disabilities etiology, Developmental Disabilities pathology
Abstract

Historical control data from prenatal developmental toxicity studies in rats have been used to evaluate whether toxicology outcomes were induced by exposure to a chemical or were within the range of spontaneous variation. These data are also important for monitoring animal characteristics. As a follow-up to historical control data from 1998 to 2010, this study analyzed control data from prenatal developmental studies performed in rats from 2011 to 2015. Data were collected from studies performed by 24 Japanese laboratories, including 15 pharmaceutical and chemical companies and nine contract research organizations, in Sprague-Dawley and two-sub-strains of Wistar Hannover rats. The data included maternal reproductive findings at terminal cesarean section and fetal findings, including incidences of spontaneous external, visceral, and skeletal anomalies. No noticeable differences in maternal reproductive data were observed among laboratories. The inter-laboratory variations in the incidences of fetal anomalies seemed to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, as well as to differences in terminology of fetal alterations. These historical control data may be helpful for adequate interpretation of experimental results and for evaluating the reproductive and developmental toxicities of various chemicals., (© 2018 Japanese Teratology Society.)

Published
2019
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