49 results on '"Huleux, Thomas"'
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2. Country of birth is associated with discrepancies in the prescription of two-drug regimens in successfully treated people living with HIV in France
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Palich, Romain, Hentzien, Maxime, Hocqueloux, Laurent, Duvivier, Claudine, Allavena, Clotilde, Huleux, Thomas, Makinson, Alain, Rey, David, Delobel, Pierre, and Cuzin, Lise
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- 2023
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3. Country of birth is associated with discrepancies in the prescription of two-drug regimens in successfully treated people with HIV in France
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Palich, Romain, Hentzien, Maxime, Hocqueloux, Laurent, Duvivier, Claudine, Allavena, Clotilde, Huleux, Thomas, Makinson, Alain, Rey, David, Delobel, Pierre, and Cuzin, Lise
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- 2023
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4. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial
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LAMAURY, Isabelle, BANI-SADR, Firouzé, FORCE, Gilles, CHABROL, Amélie, CABY, Fabienne, PATEY, Olivier, FRESARD, Anne, GAGNEUX-BRUNON, Amandine, CHIROUZE, Catherine, DUVIVIER, Claudine, LOURENCO, Jérémie, TOLSMA, Violaine, JANSSEN, Cécile, LEROLLE, Nathalie, CATALAN, Pilartxo, RAMI, Agathe, DE PONTHAUD, Lucile, PICHANCOURT, Gilles, NASRI, Safa, LANDOWSKI, Stéphanie, BOTTERO, Julie, MFUTILA KAYKAY, Flory, PIALOUX, Gilles, BOUCHAUD, Olivier, ABGRALL, Sophie, GATEY, Caroline, WEISS, Laurence, PAVIE, Juliette, SALMON-CERON, Dominique, ZUCMAN, David, LELIEVRE, Jean-Daniel, PALICH, Romain, SIMON, Anne, MEYOHAS, Marie-Caroline, GRAS, Julien, CABIE, André, PIRCHER, Mathilde, MORLAT, Philippe, HESSAMFAR, Mojgam, NEAU, Didier, CAZENAVE, Charles, GENET, Claire, FAUCHER, Jean-François, MAKHLOUFI, Djamila, BOIBIEUX, André, BREGIGEON-RONOT, Sylvie, LAROCHE, Hélène, SAUTEREAU, Aurélie, REYNES, Jacques, MAKINSON, Alain, RAFFI, François, BOLLENGIER-STRAGIER, Olivier, NAQVI, Alissa, CUA, Eric, ROSENTHAL, Eric, ARVIEUX, Cédrick, BUZELE, Rodolphe, REY, David, BATARD, Marie-Laure, BERNARD, Louis, DELOBEL, Pierre, PIFFAUT, Marie, VERDON, Renaud, PIROTH, Lionel, BLOT, Mathieu, LECLERCQ, Pascale, SIGNORI-SCHMUCK, Anne, HULEUX, Thomas, MEYBECK, Agnès, MAY, Thierry, MIAILHES, Patrick, PERPOINT, Thomas, GREDER-BELAN, Alix, ELHARRAR, Brigitte, KHUONG, Marie-Aude, POUPARD, Marie, BLUM, Laurent, MICHAU, Christophe, PRAZUCK, Thierry, PHILIBERT, Patrick, SLAMA, Laurence, HIKOMBO, Hitoto, DARASTEANU, Iuliana, GIRARD, Pierre-Marie, ALVAREZ, Jean-Claude, MATHEZ, Dominique, DE TRUCHIS, Pierre, LANDMAN, Roland, MEYNARD, Jean-Luc, MORAND-JOUBERT, Laurence, LAMBERT, Sidonie, LE DU, Damien, PERRONNE, Christian, ASSOUMOU, Lambert, COSTAGLIOLA, Dominique, MELCHIOR, Jean-Claude, DURACINSKI, Martin, PETROV-SANCHEZ, Ventzislava, AMAT, Karine, BENALYCHERIF, Aïda, SYLLA, Babacar, GELLEY, Ambre, GIBOWSKI, Séverine, LE MEUT, Guillaume, THIEBAUT, Rodolphe, CLUMECK, Nathan, LECLERCQ, Vincent, CECCHERINI-SILBERSTEIN, Francesca, DECOSTER, Laurent, Landman, Roland, de Truchis, Pierre, Assoumou, Lambert, Lambert, Sidonie, Bellet, Jonathan, Amat, Karine, Lefebvre, Bénédicte, Allavena, Clotilde, Katlama, Christine, Yazdanpanah, Yazdan, Molina, Jean-Michel, Petrov-Sanchez, Ventzislava, Gibowski, Séverine, Alvarez, Jean-Claude, Leibowitch, Jacques, Capeau, Jacqueline, Fellahi, Soraya, Duracinsky, Martin, Morand-Joubert, Laurence, Costagliola, Dominique, and Girard, Pierre-Marie
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- 2022
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5. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial
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Aboulker, Jean-Pierre, Bajos, Nathalie, Baril, Jean-Guy, Besnier, Michel, Binesse, Johan, Carette, Diane, Cattin, Grégoire, Chéret, Antoine, Chidiac, Christian, Choucair, Elias, Delfraissy, Jean-François, Demoulin, Baptiste, Diallo, Alpha, Durant-Zaleski, Isabelle, Doré, Véronique, Etien, Nicolas, Euphrasie, Françoise, Fonsart, Julien, Foubert, Valérie, Gibowski, Séverine, Girard, Gabriel, Guillon, Brigitte, Le Mestre, Soizic, Lert, France, Leturque, Nicolas, Lorente, Nicolas, Mennecier, Anaïs, Morin, Michel, Netzer, Emmanuelle, Otis, Joanne, Pasquet, Armelle, Peytavin, Gilles, Pialoux, Gilles, Préau, Marie, Rabian, Cécile, Rozenbaum, Willy, Sagaon-Teyssier, Luis, Saïdi, Yacine, Saouzanet, Marine, Simon, Marie-Christine, Suzan-Monti, Marie, Thompson, David, Timsit, Julie, Trottier, Benoît, Wainberg, Mark, Antoni, Guillemette, Tremblay, Cécile, Delaugerre, Constance, Charreau, Isabelle, Cua, Eric, Rojas Castro, Daniela, Raffi, François, Chas, Julie, Huleux, Thomas, Spire, Bruno, Capitant, Catherine, Cotte, Laurent, Meyer, Laurence, and Molina, Jean-Michel
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- 2020
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6. Routine drug resistance testing in HIV-1 proviral DNA, using an automated next- generation sequencing assay
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Alidjinou, Enagnon Kazali, Coulon, Pauline, Hallaert, Christophe, Robineau, Olivier, Meybeck, Agnès, Huleux, Thomas, Ajana, Faiza, Hober, Didier, and Bocket, Laurence
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- 2019
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7. Impact of the COVID-19 pandemic on sexual behaviour and welfare of HIV preexposure prophylaxis users: a mixed-method study.
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Kamadjou, Audrey, Decock, Anna, Huleux, Thomas, Depreux, Alma, Aissi, Emmanuelle, Landre, Laura, Baclet, Véronique, Viget, Nathalie, Valette, Michel, Robineau, Olivier, and Meybeck, Agnès
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HIV prevention ,RISK-taking behavior ,HUMAN sexuality ,RESEARCH methodology ,SEXUAL intercourse ,DRUG overdose ,CROSS-sectional method ,INTERVIEWING ,FEAR ,PRE-exposure prophylaxis ,INTIMATE partner violence ,SEX customs ,QUESTIONNAIRES ,SEXUAL excitement ,SEXUAL partners ,STAY-at-home orders ,SOCIAL distancing ,COVID-19 pandemic - Abstract
COVID-19 pandemic can affect people using HIV preexposure prophylaxis (PrEP). To assess its consequences on PrEP users' sexual behaviour and welfare, we conducted a mixed-method study. A self-administered questionnaire was given to PrEP users during scheduled consultation in Tourcoing Hospital from February to May 2021. In addition, a qualitative study included 14 participants who took part in semi-structured in-depth interviews (IDIs). Ninety-four PrEP users completed the questionnaire. During lockdown, 62% of participants continued PrEP. After lockdown release, the average number of sexual intercourses and partners increased from 6 ± 12 to 13 ± 17 intercourses/month (p < 0.001) and from 3 ± 11 to 11 ± 34 partners/month (p < 0.001). Similarly, the proportion of PrEP users who engaged in group sex, sex with alcohol or chemsex increased respectively from 28% to 55% (p < 0.001), 28% to 45% (p < 0.001) and 28% to 38% (p < 0.001). Analysis of IDIs revealed emotional deprivation and sexual frustration during the lockdown. After its release, frequent clandestine chemsex parties and curfew forcing overnight stay increased fears of intimate violence and overdoses. In conclusion, PrEP users reduced their sexual activity during the lockdown. Its release led to an increase in sexual risk-taking. Social distancing measures could favour medical and social harm of sexual risk-taking. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Accuracy of endobronchial ultrasound-guided transbronchial needle aspiration in HIV-infected patients with thoracic lymphadenopathy in a tuberculosis low-burden area
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Tetart, Macha, Betraoui, Farid, Huleux, Thomas, Wallyn, Frédéric, Brichet, Anne, Thill, Pauline, Robineau, Olivier, and Meybeck, Agnès
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- 2020
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9. Kaposi sarcoma in people living with HIV: incidence and associated factors in a French cohort between 2010 and 2015
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Poizot-Martin, Isabelle, Lions, Caroline, Cheret, Antoine, Rey, David, Duvivier, Claudine, Jacomet, Christine, Allavena, Clotilde, Huleux, Thomas, Bani-Sadr, Firouze, Obry-Roguet, Véronique, and Makinson, Alain
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- 2020
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10. Impact of the COVID-19 pandemic on sexual behaviour and welfare of HIV preexposure prophylaxis users: a mixed-method study
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Kamadjou, Audrey, primary, Decock, Anna, additional, Huleux, Thomas, additional, Depreux, Alma, additional, Aissi, Emmanuelle, additional, Landre, Laura, additional, Baclet, Véronique, additional, Viget, Nathalie, additional, Valette, Michel, additional, Robineau, Olivier, additional, and Meybeck, Agnès, additional
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- 2023
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11. Country of birth is associated with antiretroviral therapy choice in treatment-naive persons living with HIV in France
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Palich, Romain, primary, Hentzien, Maxime, additional, Hocqueloux, Laurent, additional, Duvivier, Claudine, additional, Allavena, Clotilde, additional, Huleux, Thomas, additional, Delobel, Pierre, additional, Makinson, Alain, additional, Rey, David, additional, and Cuzin, Lise, additional
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- 2023
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12. In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control
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Trémeaux, Pauline, primary, Lemoine, Frédéric, additional, Mélard, Adeline, additional, Gousset, Marine, additional, Boufassa, Faroudy, additional, Orr, Sylvie, additional, Monceaux, Valérie, additional, Gascuel, Olivier, additional, Lambotte, Olivier, additional, Hocqueloux, Laurent, additional, Saez-Cirion, Asier, additional, Rouzioux, Christine, additional, Avettand-Fenoel, Véronique, additional, Bani-Sadr, Firouzé, additional, Hentzien, Maxime, additional, Berger, Jean-Luc, additional, Kmiec, Isabelle, additional, Pichancourt, Gilles, additional, Nasri, Safa, additional, Hittinger, Gilles, additional, Lambry, Véronique, additional, Beaudrey, Anne-Cécile, additional, Pialoux, Gilles, additional, Chas, Julie, additional, Palacios, Christia, additional, Adda, Anne, additional, Viard, Jean Paul, additional, Dulucq, Marie-Josée, additional, Weiss, Laurence, additional, Karmochkine, Marina, additional, Meghadecha, Mohamed, additional, Salmon-Ceron, Dominique, additional, Piétri, Marie-Pierre, additional, Blanche, Philippe, additional, Molina, Jean-Michel, additional, Taulera, Olivier, additional, Ponscarme, Diane, additional, Delgado Bertaut, Jeannine, additional, Makhloufi, Djamila, additional, Godinot, Matthieu, additional, Artizzu, Valérie, additional, Miailhes, Patrick, additional, Cotte, Laurent, additional, Pailhes, Sophie, additional, Conrad, Anne, additional, Karkowski, Ludovic, additional, Ogoudjobi, Stanislas, additional, Yazdanpanah, Yazdan, additional, Matheron, Sophie, additional, Godard, Cindy, additional, Bernard, Louis, additional, Bastides, Frédéric, additional, Bourgault, Olivier, additional, Jacomet, Christine, additional, Goncalves, Emilie, additional, Chavanet, Pascal, additional, Piroth, Lionel, additional, Gohier, Sandrine, additional, Meybeck, Agnès, additional, Huleux, Thomas, additional, Cornavin, Pauline, additional, Debab, Yasmine, additional, Théron, David, additional, Prazuck, Thierry, additional, De Dieuleveult, Barbara, additional, Faller, Jean-Pierre, additional, Eglinger, Patricia, additional, Roblot, Pascal, additional, Plainchamp, David, additional, Aumaître, Hugues, additional, Malet, Martine, additional, Rouger, Christine, additional, Rémy, Gérard, additional, Isabelle, Melle Kmiec, additional, Delassus, Jean-Luc, additional, Devidas, Alain, additional, Froguel, Eric, additional, Tassi, Sylvie, additional, Genet, Philippe, additional, Gerbe, Juliette, additional, Patey, Olivier, additional, Laurent, Richier, additional, Drobacheff, Marie-Christine, additional, Proust, Aurélie, additional, Gil, Helder, additional, Gérard, Laurence, additional, Oksenhendler, Eric, additional, Lascoux, Caroline, additional, Parlier, Sylvie, additional, Lucht, Frédéric, additional, Ronat, Véronique, additional, Dupon, Michel, additional, Dutronc, Hervé, additional, Le Puil, Séverine, additional, Neau, Didier, additional, Mercié, Patrick, additional, Morlat, Philippe, additional, Caldato, Sabrina, additional, Schmit, Jean-Luc, additional, Decaux, Nathalie, additional, Bru, Jean-Pierre, additional, Clavere, Gaëlle, additional, Delfraissy, Jean-François, additional, Goujard, Cécile, additional, Bourdic, Katia, additional, Vittecoq, Daniel, additional, Bolliot, Claudine, additional, Lambert, Thierry, additional, Bergmann, Jean-François, additional, Parrinello, Maguy, additional, Welker, Yves, additional, Lafeuillade, Alain, additional, Philip, Gisèle, additional, Rapp, Christophe, additional, Lerondel, Melle, additional, de Truchis, Pierre, additional, Huguette, Berthe, additional, Jeantils, Vincent, additional, Mchangama, Fatouma, additional, Consigny, Paul Henri, additional, Touam, Fatima, additional, le Nagat, Sophie, additional, Bouchaud, Olivier, additional, Honoré, Patricia, additional, Boué, François, additional, Raho-Moussa, Mariem, additional, Viard, Jean-Paul, additional, Cros, Agnès, additional, Salmon-Céron, Dominique, additional, Pietri, Marie-Pierre, additional, Collias, Lio, additional, Zucman, David, additional, Blétry, Olivier, additional, Bornarel, Dominique, additional, Mortier, Emmanuel, additional, Feng, Zeng, additional, Lelièvre, Jean-Daniel, additional, Katlama, Christine, additional, Dudoit, Yasmine, additional, Simon, Anne, additional, Lupin, Catherine, additional, Girard, Pierre-Marie, additional, Pauchard, Michèle, additional, Abel, Sylvie, additional, Cabié, André, additional, Fialaire, Pascale, additional, Chennebault, Jean-Marie, additional, Rehaiem, Sami, additional, de Saint Martin, Luc, additional, Perfezou, ••••, additional, Duthe, Jean-Charles, additional, Weinbreck, Pierre, additional, Genet, Claire, additional, Garnier, Florence, additional, Poizot-Martin, Isabelle, additional, Fauche, Olivia, additional, Ivanova, Alena, additional, Philibert, Patrick, additional, Penda Sow, Mame, additional, Yeni, Patrick, additional, Godard, Cyndi, additional, Raffi, François, additional, Hüe, Hervé, additional, Perré, Philippe, additional, Roger, Pierre Marie, additional, Joulie, Aline, additional, Rosenthal, Éric, additional, Michelet, Christian, additional, Souala, Faouzi, additional, Ratajczak, Maja, additional, Partisani, Marialuisa, additional, Fischer, Patricia, additional, Nau, Pascale, additional, Delobel, Pierre, additional, Balsarin, Florence, additional, De Lavaissiere, Marc, additional, Verdon, Renaud, additional, Feret, Philippe, additional, Leclercq, Pascale, additional, Gerberon, ••••, additional, Meybeck, Agnés, additional, Biekre, Raphaël, additional, May, Thierry, additional, Bouillon, ••••, additional, Caron, François, additional, Theron, David, additional, Gatfosse, Marc, additional, Martinot, Martin, additional, Pachart, Anne, additional, Poubeau, Patrice, additional, Gaud, Catherine, additional, Uludag, Agnès, additional, Arsac, Philippe, additional, Bouaraba, Lydia, additional, de Dieulevault, Barbara, additional, De Lacroix Szmania, Isabelle, additional, Richier, Laurent, additional, Daneluzzi, Vincent, additional, Rouveix, Elisabeth, additional, Beck-Wirth, Geneviève, additional, Romand, Philippe, additional, Blum, Laurent, additional, Deschaud, Martine, additional, Michau, Christophe, additional, Bernard, Christian, additional, Salaun, Florence, additional, Muller, Philippe, additional, Poinsignon, Yves, additional, Lepretre, Annie, additional, Sotto, Albert, additional, Doncesco, ••••, additional, Perfezou, Pascale, additional, Duthe, Jean Charles, additional, Niault, Mathilde Aurore, additional, Mouton-Rioux, Virginie, additional, Talarmin, Jean-Philippe, additional, Duthé, Jean Charles, additional, Dupont, Mathilde, additional, Natur, Stéphane, additional, Hitoto, Hikombo, additional, and Ibrahim, Ali Mahamadou, additional
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- 2023
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13. Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers
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Molinos-Albert, Luis, Lorin, Valerie, Monceaux, Valérie, Orr, Sylvie, Essat, Asma, Dufloo, Jérémy, Schwartz, Olivier, Rouzioux, Christine, Meyer, Laurence, Hocqueloux, Laurent, Sáez-Cirión, Asier, Mouquet, Hugo, Group, Anrs Visconti Study, Prazuck, Thierry, Dieuleveult, Barbara De, Bani-Sadr, Firouzé, Hentzien, Maxime, Berger, Jean-Luc, Kmiec, Isabelle, Pichancourt, Gilles, Nasri, Safa, Hittinger, Gilles, Lambry, Véronique, Beauey, Anne-Cécile, Pialoux, Gilles, Palacios, Christia, Siguier, Martin, Adda, Anne, Foucoin, Jane, Weiss, Laurence, Karmochkine, Marina, Meghadecha, Mohamed, Ptak, Magali, Salmon-Ceron, Dominique, Blanche, Philippe, Piétri, Marie-Pierre, Molina, Jean-Michel, Taulera, Olivier, Lascoux-Combe, Caroline, Ponscarme, Diane, Bertaut, Jeannine Delgado, Makhloufi, Djamila, Godinot, Matthieu, Artizzu, Valérie, Yazdanpanah, Yazdan, Matheron, Sophie, Godard, Cindy, Julia, Zélie, Bernard, Louis, Bastides, Frédéric, Bourgault, Olivier, Jacomet, Christine, Goncalves, Emilie, Meybeck, Agnès, Huleux, Thomas, Cornavin, Pauline, Debab, Yasmine, Théron, David, Miailhes, Patrick, Cotte, Laurent, Pailhes, Sophie, Ogoudjobi, Stanislas, Viard, Jean Paul, Dulucq, Marie-Josée, Bodard, Loïc, Churaqui, Francoise, Guimard, Thomas, Laine, Laetitia, Immunologie humorale - Humoral Immunology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Virus et Immunité - Virus and immunity (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service de Microbiologie Clinique [Paris], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), La Source Hospital-CHR, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Hospitalier Henri Duffaut (Avignon), CHI de Toulon, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hopital Saint-Louis [AP-HP] (AP-HP), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Centre Hospitalier Gustave Dron [Tourcoing], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Hôpital de la Croix-Rousse [CHU - HCL], Hôpital Hôtel-Dieu [Paris], Institut mutualiste Monsouris (IMM), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), We thank the NIH AIDS Reagent Program (Division of AIDS, NIAID, NIH) for contributing to reagents and the Agence National de Recherche sur le SIDA et les hépatites virales (ANRS) for an equipment grant support (AO2013-2 #13553, H.M.). L.M. M-A. is the recipient of a postdoctoral fellowship from the Pasteur-Roux-Cantarini program (Institut Pasteur). H.M. received core grants from the Institut Pasteur, the INSERM and the Milieu Intérieur Program (ANR-10-LABX-69-01). This work was conducted in the context of the ANRS RHIVIERA consortium, and was supported by the ANRS and the NIH/NIAID (grant #: P01AI131365, H.M.)., ANRS VISCONTI Study Group Thierry Prazuck, Barbara De Dieuleveult, Firouzé Bani-Sadr, Maxime Hentzien, Jean-Luc Berger, Isabelle Kmiec, Gilles Pichancourt, Safa Nasri, Gilles Hittinger, Véronique Lambry, Anne-Cécile Beauey, Gilles Pialoux, Christia Palacios, Martin Siguier, Anne Adda, Jane Foucoin, Laurence Weiss, Marina Karmochkine, Mohamed Meghadecha, Magali Ptak, Dominique Salmon-Ceron, Philippe Blanche, Marie-Pierre Piétri, Jean-Michel Molina, Olivier Taulera, Caroline Lascoux-Combe, Diane Ponscarme, Jeannine Delgado Bertaut, Djamila Makhloufi, Matthieu Godinot, Valérie Artizzu, Yazdan Yazdanpanah, Sophie Matheron, Cindy Godard, Zélie Julia, Louis Bernard, Frédéric Bastides, Olivier Bourgault, Christine Jacomet, Emilie Goncalves, Agnès Meybeck, Thomas Huleux, Pauline Cornavin, Yasmine Debab, David Théron, Patrick Miailhes, Laurent Cotte, Sophie Pailhes, Stanislas Ogoudjobi, Jean Paul Viard, Marie-Josée Dulucq, Loïc Bodard, Francoise Churaqui, Thomas Guimard & Laetitia Laine, ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Institut Pasteur [Paris]-Université Paris Cité (UPC), Virus et Immunité - Virus and immunity, and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC)
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Multidisciplinary ,MESH: Humans ,General Physics and Astronomy ,HIV Infections ,General Chemistry ,MESH: HIV Infections ,Antibodies, Neutralizing ,General Biochemistry, Genetics and Molecular Biology ,Immunity, Humoral ,MESH: Antibodies, Neutralizing ,MESH: HIV-1 ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,HIV-1 ,Humans ,Viremia ,MESH: Immunity, Humoral ,MESH: Viremia - Abstract
HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.
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- 2022
14. Country of birth is associated with antiretroviral therapy choice in treatment-naive persons with HIV in France.
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Palich, Romain, Hentzien, Maxime, Hocqueloux, Laurent, Duvivier, Claudine, Allavena, Clotilde, Huleux, Thomas, Delobel, Pierre, Makinson, Alain, Rey, David, and Cuzin, Lise
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- 2023
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15. Smoking‐associated morbidities on computed tomography lung cancer screens in HIV‐infected smokers
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Bommart, S, Cournil, A, Eymard‐Duvernay, S, Raffi, F, Bouassida, I, Le Moing, V, Reynes, J, Makinson, A, Yazdanpanah, Yazdan, Cheret, Antoine, Ajana, Faïza, Alcaraz, Isabelle, Baclet, Véronique, Melliez, Hugues, Valette, Michel, Viget, Nathalie, De La Tribonniere, Xavier, Huleux, Thomas, Séverine, Séverine Bonne, Biekre, Raphaël, Pasquet, Armelle, Allienne, Christophe, Behra, Jean Marie, Meybeck, Agnès, Aissi, Emmanuelle, Abgrall, Sophie, Bouchaud, Olivier, Barruet, Régine, Rouges, François, Kandel, Tania, Mechai, Fréderic, Brillet, Pierre‐Yves, Brauner, Michel, Dellamonica, Pierre, De Salvador, Francine, Cua, Eric, Leplatois, Anne, Naqvi, Alissa, Durant, Jacques, Ceppi, Carole, Sanderson, Frédéric, Rosenthal, Eric, Chassang, Madleen, Chevallier, Patrick, Dunais, Brigitte, Tattevin, Pierre, Lena, Hervé, Lentz, Pierre‐Axel, Michelet, Christian, Arvieux, Cédric, Revest, Mathieu, Soula, Faouzi, Chapplain, Jean‐Marc, Leroy, Hélène, Meunier, Catherine, Poizot‐Martin, Isabelle, Faucher, Olivia, Menard, Amélie, Bregigeon, Sylvie, de Lamarliere, Perrine Geneau, Champsaur, Pierre, Durieux, Olivier, Cloarec, Nicolas, Allavena, Clotilde, Feuillebois, Nicolas, Mounoury, Olivier, Bouchez, Sabelline, Billaud, Eric, Reliquet, Véronique, Bonnet, Bénédicte, Brunet, Cécile, Point, Patrick, Boutoille, David, Le Houssine, Pascale Morineau, Delemazure, Anne Sophie, Duvivier, Claudine, Catherinot, Emilie, Tehrani, Michka Shoai, Poiree, Sylvain, Zucman, David, Majerholc, Catherine, Couderc, Louis‐Jean, Mellot, François, Sherrer, Antoine, Ferry, Tristan, Koffi, Joseph, Boibieux, André, Miailhes, Patrick, Cotte, Laurent, Perpoint, Thomas, Lippman, Joanna, Norman, Claude Augustin, biron, Francois, Senechar, Agathe, Ader, Florence, Pialloux, Gilles, LʼYavanc, Thomas, Slama, Laurence, Chas, Julie, Le Nagat, Sophie, Khalil, Antoine, Carette, Marie France, Bonnet, Fabrice, Morlat, Philippe, Lacoste, Denis, Vandenhende, Marie, Receveur, Marie Catherine, Paccalin, Francois, Caldato, Sabrina, Bernard, Noëlle, Hessemfar, Mojgan, Pistone, Thierry, Malvy, Denis, Thibaut, Pierre, Pertusa, Marie Carmen, Cornelou, Olivier, Laurent, Francois, Mercie, Patrick, Faure, Isabelle, Dondia, Denis, Martell, Cedric, Duffau, Pierre, Mauboussin, Jean Marc, Barbuat, Claudine, Rouanet, Isabelle, Metge, Liliane, Jacquet, Jean‐Marc, Atoui, Nadine, Loriette, Mickael, Morquin, David, Fauchere, Vincent, Favier, Carine, Merle, Corinne, Baillat, Vincent, Silva, Antoine Da, Mansouri, Rachid, Kovacsik‐Vernhet, Hélène, Pujol, Jean‐Louis, Quantin, Xavier, and Hayot, Maurice
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- 2017
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16. Initiation of Antiretroviral Therapy Containing Integrase Inhibitors Increases the Risk of IRIS Requiring Hospitalization
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Dutertre, Marine, Cuzin, Lise, Demonchy, Elisa, Puglièse, Pascal, Joly, Véronique, Valantin, Marc-Antoine, Cotte, Laurent, Huleux, Thomas, Delobel, Pierre, and Martin-Blondel, Guillaume
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- 2017
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17. High syphilis prevalence and incidence in people living with HIV and Preexposure Prophylaxis users: A retrospective review in the French Dat’AIDS cohort
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Lemmet, Thomas, primary, Cotte, Laurent, additional, Allavena, Clotilde, additional, Huleux, Thomas, additional, Duvivier, Claudine, additional, Laroche, Hélène, additional, Cabie, André, additional, Pugliese, Pascal, additional, Jovelin, Thomas, additional, Maurel, Marine, additional, Delpierre, Cyrille, additional, and Rey, David, additional
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- 2022
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18. A highly virulent variant of HIV-1 circulating in the Netherlands
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Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Van Frankenhuijsen, Maartje, Allegre, Thierry, Makhloufi, Djamila, Livrozet, Jean-Michel, Chiarello, Pierre, Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, Marc-Olivier, Wirth, Gaétane, Le Puil, Séverine, Pellegrin, Jean-Luc, Raymond, Isabelle, Viallard, Jean-François, Chaigne de Lalande, Severin, Garipuy, Daniel, Delobel, Pierre, Obadia, Martine, Cuzin, Lise, Alvarez, Muriel, Biezunski, Noemie, Porte, Lydie, Massip, Patrice, Debard, Alexa, Balsarin, Florence, Lagarrigue, Myriam, Prevoteau du Clary, François, Aquilina, Christian, Reynes, Jacques, Baillat, Vincent, Merle, Corinne, Lemoing, Vincent, Atoui, Nadine, Makinson, Alain, Jacquet, Jean Marc, Psomas, Christina, Tramoni, Christine, Aumaitre, Hugues, Saada, Mathieu, Medus, Marie, Malet, Martine, Eden, Aurélia, Neuville, Ségolène, Ferreyra, Milagros, Sotto, Albert, Barbuat, Claudine, Rouanet, Isabelle, Leureillard, Didier, Mauboussin, Jean-Marc, Lechiche, Catherine, Donsesco, Régine, Cabie, André, Abel, Sylvie, Pierre-Francois, Sandrine, Batala, Anne-Sophie, Cerland, Christophe, Rangom, Camille, Theresine, Nadine, Hoen, Bruno, Lamaury, Isabelle, Fabre, Isabelle, Schepers, Kinda, Curlier, Elodie, Ouissa, Rachida, Gaud, Catherine, Ricaud, Carole, Rodet, Roland, Wartel, Guillaume, Sautron, Carmele, Beck-Wirth, Geneviève, Michel, Catherine, Beck, Charles, Halna, Jean-Michel, Kowalczyk, Jakub, Benomar, Meryem, Drobacheff-Thiebaut, Christine, Chirouze, Catherine, Faucher, Jean-François, Parcelier, François, Foltzer, Adeline, Haffner-Mauvais, Cécile, Hustache Mathieu, Mathieu, Proust, Aurélie, Piroth, Lionel, Chavanet, Pascal, Duong, Michel, Buisson, Marielle, Waldner, Anne, Mahy, Sophie, Gohier, Sandrine, Croisier, Delphine, May, Thierry, Delestan, Mikael, Andre, Marie, Zadeh, Mahsa Mohseni, Martinot, Martin, Rosolen, Béatrice, Pachart, Anne, Martha, Benoît, Jeunet, Noëlle, Rey, David, Cheneau, Christine, Partisani, Maria, Priester, Michèle, Bernard-Henry, Claudine, Batard, Marie-Laure, Fischer, Patricia, Berger, Jean-Luc, Kmiec, Isabelle, Robineau, Olivier, Huleux, Thomas, Ajana, Faïza, Alcaraz, Isabelle, Allienne, Christophe, Baclet, Véronique, Meybeck, Agnès, Valette, Michel, Viget, Nathalie, Aissi, Emmanuelle, Biekre, Raphael, Cornavin, Pauline, Merrien, Dominique, Seghezzi, Jean-Christophe, Machado, Moise, Diab, Georges, Raffi, François, Bonnet, Bénédicte, Allavena, Clotilde, Grossi, Olivier, Reliquet, Véronique, Billaud, Eric, Brunet, Cecile, Bouchez, Sabelline, Morineau-Le Houssine, Pascale, Sauser, Fabienne, Boutoille, David, Besnier, Michel, Hue, Hervé, Hall, Nolwenn, Brosseau, Delphine, Souala, Faouzi, Michelet, Christian, Tattevin, Pierre, Arvieux, Cédric, Revest, Matthieu, Leroy, Helene, Chapplain, Jean-Marc, Dupont, Matthieu, Fily, Fabien, Patra-Delo, Solène, Lefeuvre, Céline, Bernard, Louis, Bastides, Frédéric, Nau, Pascale, Verdon, Renaud, de la Blanchardiere, Arnaud, Martin, Anne, Feret, Philippe, Geffray, Loïk, Daniel, Corinne, Rohan, Jennifer, Fialaire, Pascale, Chennebault, Jean Marie, Rabier, Valérie, Abgueguen, Pierre, Rehaiem, Sami, Luycx, Odile, Niault, Mathilde, Moreau, Philippe, Poinsignon, Yves, Goussef, Marie, Mouton-Rioux, Virginie, Houlbert, Dominique, Alvarez-Huve, Sandrine, Barbe, Frédérique, Haret, Sophie, Perre, Philippe, Leantez-Nainville, Sophie, Esnault, Jean-Luc, Guimard, Thomas, Suaud, Isabelle, Girard, Jean-Jacques, Simonet, Véronique, Debab, Yasmine, Schmit, Jean-Luc, Jacomet, Christine, Weinberck, Pierre, Genet, Claire, Pinet, Pauline, Ducroix, Sophie, Durox, Hélène, Denes, Éric, Abraham, Bruno, Gourdon, Florence, Antoniotti, Odile, Molina, Jean-Michel, Ferret, Samuel, Lascoux-Combe, Caroline, Lafaurie, Matthieu, Colin de Verdiere, Nathalie, Ponscarme, Diane, De Castro, Nathalie, Aslan, Alexandre, Rozenbaum, Willy, Pintado, Claire, Clavel, François, Taulera, Olivier, Gatey, Caroline, Munier, Anne-Lise, Gazaigne, Sandrine, Penot, Pauline, Conort, Guillaume, Lerolle, Nathalie, Leplatois, Anne, Balausine, Stéphanie, Delgado, Jeannine, Timsit, Julie, Tabet, Magda, Gerard, Laurence, Girard, Pierre-Marie, Picard, Odile, Tredup, Jürgen, Bollens, Diane, Valin, Nadia, Campa, Pauline, Bottero, Julie, Lefebvre, Benedicte, Tourneur, Muriel, Fonquernie, Laurent, Wemmert, Charlotte, Lagneau, Jean-Luc, Yazdanpanah, Yazdan, Phung, Bao, Pinto, Adriana, Vallois, Dorothée, Cabras, Ornella, Louni, Françoise, Pialoux, Gilles, Lyavanc, Thomas, Berrebi, Valérie, Chas, Julie, Lenagat, Sophie, Rami, Agathe, Diemer, Myriam, Parrinello, Maguy, Depond, Audrey, Salmon, Dominique, Guillevin, Loïc, Tahi, Tassadit, Belarbi, Linda, Loulergue, Pierre, Zak Dit Zbar, Olivier, Launay, Odile, Silbermann, Benjamin, Leport, Catherine, Alagna, Laura, Pietri, Marie-Pierre, Simon, Anne, Bonmarchand, Manuela, Amirat, Naouel, Pichon, François, Kirstetter, Myriam, Katlama, Christine, Valantin, Marc Antoine, Tubiana, Roland, Caby, Fabienne, Schneider, Luminita, Ktorza, Nadine, Calin, Ruxandra, Merlet, Audrey, Ben Abdallah, Saadia, Weiss, Laurence, Buisson, Martin, Batisse, Dominique, Karmochine, Marina, Pavie, Juliette, Minozzi, Catherine, Jayle, Didier, Castel, Philippe, Derouineau, Jean, Kousignan, Pascale, Eliazevitch, Murielle, Pierre, Isabelle, Collias, Lio, Viard, Jean-Paul, Gilquin, Jacques, Sobel, Alain, Slama, Laurence, Ghosn, Jade, Hadacek, Blanka, Thu-Huyn, Nugyen, Nait-Ighil, Lella, Cros, Agnes, Maignan, Aline, Duvivier, Claudine, Consigny, Paul Henri, Lanternier, Fanny, Shoai-Tehrani, Michka, Touam, Fatima, Jerbi, Saadia, Bodard, Loïc, Jung, Corinne, Goujard, Cécile, Quertainmont, Yann, Duracinsky, Martin, Segeral, Olivier, Blanc, Arnaud, Peretti, Delphine, Cheret, Antoine, Chantalat, Christelle, Dulucq, Marie Josée, Levy, Yves, Lelievre, Jean Daniel, Lascaux, Anne Sophie, Dumont, Cécile, Boue, François, Chambrin, Véronique, Abgrall, Sophie, Kansau, Imad, Raho-Moussa, Mariem, De Truchis, Pierre, Dinh, Aurélien, Davido, Benjamin, Marigot, Dhiba, Berthe, Huguette, Devidas, Alain, Chevojon, Pierre, Chabrol, Amélie, Agher, Nouara, Lemercier, Yvon, Chaix, Fabrice, Turpault, Isabelle, Bouchaud, Olivier, Honore, Patricia, Rouveix, Elisabeth, Reimann, Evelyne, Belan, Alix Greder, Godin Collet, Claire, Souak, Safia, Mortier, Emmanuel, Bloch, Martine, Simonpoli, Anne-Marie, Manceron, Véronique, Cahitte, Isabelle, Hiraux, Emmanuel, Lafon, Erik, Cordonnier, François, Zeng, Ai-Feng, Zucman, David, Majerholc, Catherine, Bornarel, Dominique, Uludag, Agnès, Gellen-Dautremer, Justine, Lefort, Agnès, Bazin, Christine, Daneluzzi, Vincent, Gerbe, Juliette, Jeantils, Vincent, Coupard, Mélissa, Patey, Olivier, Bantsimba, Jonas, Delllion, Sophie, Paz, Pauline Caraux, Cazenave, Benoit, Richier, Laurent, Garrait, Valérie, Delacroix, Isabelle, Elharrar, Brigitte, Vittecoq, Daniel, Bolliot, Claudine, Lepretre, Annie, Genet, Philippe, Masse, Virginie, Perrone, Véronique, Boussard, Jean-Luc, Chardon, Patricia, Froguel, Eric, Simon, Philippe, Tassi, Sylvie, Avettand Fenoel, Véronique, Barin, Francis, Bourgeois, Christine, Cardon, Fanny, Chaix, Marie-Laure, Delfraissy, Jean François, Essat, Asma, Fischer, Hugues, Lecuroux, Camille, Petrov-Sanchez, Ventzislava, Rouzioux, Christine, Saez-Cirion, Asier, Seng, Rémonie, Kuldanek, Kristin, Mullaney, Scott, Young, Carmel, Zucchetti, Antonella, Bevan, Margaret-Ann, McKernan, Sinead, Wandolo, Emily, Richardson, Celia, Youssef, Elaney, Green, Pippa, Faulkner, Sue, Faville, Rebecca, Herman, Sandra, Care, Christine, Blackman, Helen, Bellenger, Katharine, Fairbrother, Keith, Phillips, Andrew, Babiker, Abdel, Delpech, Valerie, Fidler, S, Clarke, Mindy, Fox, Julie, Gilson, R, Goldberg, David, Hawkins, David, Johnson, Anne, Johnson, Margaret, McLean, Ken, Nastouli, Eleni, Post, Frank, Kennedy, N, Pritchard, J, Andrady, U, Rajda, N, Donnelly, C, McKernan, S, Drake, S, Gilleran, G, White, D, Ross, J, Harding, J, Faville, R, Sweeney, J, Flegg, P, Toomer, S, Wilding, H, Woodward, R, Dean, G, Richardson, C, Perry, N, Gompels, M, Jennings, L, Bansaal, D, Browing, M, Connolly, L, Stanley, B, Estreich, S, Magdy, A, O'Mahony, C, Fraser, P, Jebakumar, S P R, David, L, Mette, R, Summerfield, H, Evans, M, White, C, Robertson, R, Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
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Adult ,Male ,HIV-1/genetics ,Genotype ,Anti-HIV Agents ,Evolution ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections/drug therapy ,selection ,HIV Infections ,Genome, Viral ,heritability ,epidemic ,human-immunodeficiency-virus ,Evolution, Molecular ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Viral ,Phylogeny ,Netherlands ,Multidisciplinary ,Genome ,model ,Virulence ,transmission ,Molecular ,setpoint viral load ,reverse-transcriptase ,dynamics ,Viral Load ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,3121 General medicine, internal medicine and other clinical medicine ,Anti-HIV Agents/therapeutic use ,Mutation ,HIV-1 ,Female ,progression - Abstract
Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
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- 2022
19. Incidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France
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Rojas Rojas, Teresa, Poizot-Martin, Isabelle, Rey, David, Duvivier, Claudine, Bani-Sadr, Firouzé, Cabie, André, Delobel, Pierre, Jacomet, Christine, Allavena, Clotilde, Ferry, Tristan, Pugliese, Pascal, Valantin, Marc-Antoine, Lamaury, Isabelle, Hustache-Matthieu, Laurent, Fresard, Anne, Houyou, Tamazighth, Huleux, Thomas, Cheret, Antoine, Makinson, Alain, Obry-Roguet, Véronique, Lions, Caroline, Carrieri, Maria, Protopopescu, Camelia, Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), Les Hôptaux universitaires de Strasbourg (HUS), CHU Strasbourg, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Hôpital Robert Debré, Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), CHU de la Martinique [Fort de France], Université des Antilles (UA), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Clermont-Ferrand, Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Hôtel-Dieu de Nantes, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Nice (CHU Nice), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Centre Hospitalier Gustave Dron [Tourcoing], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Sorbonne Paris Cité (USPC), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Infectious and Tropical Diseases Department [Montpellier], Institut de Recherche pour le Développement (IRD)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Etienne, and DIAMANT-BERGER, Valérie
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Male ,Multidisciplinary ,Coinfection ,Incidence ,Uterine Cervical Neoplasms ,Breast Neoplasms ,HIV Infections ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Hepatitis C ,[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Risk Factors ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Colorectal Neoplasms ,Retrospective Studies - Abstract
Background We aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program. Setting This is a retrospective study based on the longitudinal data of the French Dat’AIDS cohort. Methods Standardized incidence ratios (SIR) for ICC and BC, and incidence rates for all three cancers were calculated overall and for specific sub-populations according to nadir CD4 cell count, HIV transmission category, HIV diagnosis period, and HCV coinfection. Results The 2010–2015 CRC incidence rate was 25.0 [95% confidence interval (CI): 18.6–33.4] per 100,000 person-years, in 44,642 PLWH (both men and women). Compared with the general population, the ICC incidence rate was significantly higher in HIV-infected women both overall (SIR = 1.93, 95% CI: 1.18–3.14) and in the following sub-populations: nadir CD4 ≤ 200 cells/mm3 (SIR = 2.62, 95% CI: 1.45–4.74), HIV transmission through intravenous drug use (SIR = 5.14, 95% CI: 1.93–13.70), HCV coinfection (SIR = 3.52, 95% CI: 1.47–8.47) and HIV diagnosis before 2000 (SIR = 2.06, 95% CI: 1.07–3.97). Conversely, the BC incidence rate was significantly lower in the study sample than in the general population (SIR = 0.56, 95% CI: 0.42–0.73). Conclusion The present study showed no significant linear trend between 2010 and 2015 in the incidence rates of the three cancers explored in the PLWH study sample. Specific recommendations for ICC screening are still required for HIV-infected women and should focus on sub-populations at greatest risk.
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- 2022
20. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial
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Landman, Roland, primary, de Truchis, Pierre, additional, Assoumou, Lambert, additional, Lambert, Sidonie, additional, Bellet, Jonathan, additional, Amat, Karine, additional, Lefebvre, Bénédicte, additional, Allavena, Clotilde, additional, Katlama, Christine, additional, Yazdanpanah, Yazdan, additional, Molina, Jean-Michel, additional, Petrov-Sanchez, Ventzislava, additional, Gibowski, Séverine, additional, Alvarez, Jean-Claude, additional, Leibowitch, Jacques, additional, Capeau, Jacqueline, additional, Fellahi, Soraya, additional, Duracinsky, Martin, additional, Morand-Joubert, Laurence, additional, Costagliola, Dominique, additional, Girard, Pierre-Marie, additional, LAMAURY, Isabelle, additional, BANI-SADR, Firouzé, additional, FORCE, Gilles, additional, CHABROL, Amélie, additional, CABY, Fabienne, additional, PATEY, Olivier, additional, FRESARD, Anne, additional, GAGNEUX-BRUNON, Amandine, additional, CHIROUZE, Catherine, additional, DUVIVIER, Claudine, additional, LOURENCO, Jérémie, additional, TOLSMA, Violaine, additional, JANSSEN, Cécile, additional, LEROLLE, Nathalie, additional, CATALAN, Pilartxo, additional, RAMI, Agathe, additional, DE PONTHAUD, Lucile, additional, PICHANCOURT, Gilles, additional, NASRI, Safa, additional, LANDOWSKI, Stéphanie, additional, BOTTERO, Julie, additional, MFUTILA KAYKAY, Flory, additional, PIALOUX, Gilles, additional, BOUCHAUD, Olivier, additional, ABGRALL, Sophie, additional, GATEY, Caroline, additional, WEISS, Laurence, additional, PAVIE, Juliette, additional, SALMON-CERON, Dominique, additional, ZUCMAN, David, additional, LELIEVRE, Jean-Daniel, additional, PALICH, Romain, additional, SIMON, Anne, additional, MEYOHAS, Marie-Caroline, additional, GRAS, Julien, additional, CABIE, André, additional, PIRCHER, Mathilde, additional, MORLAT, Philippe, additional, HESSAMFAR, Mojgam, additional, NEAU, Didier, additional, CAZENAVE, Charles, additional, GENET, Claire, additional, FAUCHER, Jean-François, additional, MAKHLOUFI, Djamila, additional, BOIBIEUX, André, additional, BREGIGEON-RONOT, Sylvie, additional, LAROCHE, Hélène, additional, SAUTEREAU, Aurélie, additional, REYNES, Jacques, additional, MAKINSON, Alain, additional, RAFFI, François, additional, BOLLENGIER-STRAGIER, Olivier, additional, NAQVI, Alissa, additional, CUA, Eric, additional, ROSENTHAL, Eric, additional, ARVIEUX, Cédrick, additional, BUZELE, Rodolphe, additional, REY, David, additional, BATARD, Marie-Laure, additional, BERNARD, Louis, additional, DELOBEL, Pierre, additional, PIFFAUT, Marie, additional, VERDON, Renaud, additional, PIROTH, Lionel, additional, BLOT, Mathieu, additional, LECLERCQ, Pascale, additional, SIGNORI-SCHMUCK, Anne, additional, HULEUX, Thomas, additional, MEYBECK, Agnès, additional, MAY, Thierry, additional, MIAILHES, Patrick, additional, PERPOINT, Thomas, additional, GREDER-BELAN, Alix, additional, ELHARRAR, Brigitte, additional, KHUONG, Marie-Aude, additional, POUPARD, Marie, additional, BLUM, Laurent, additional, MICHAU, Christophe, additional, PRAZUCK, Thierry, additional, PHILIBERT, Patrick, additional, SLAMA, Laurence, additional, HIKOMBO, Hitoto, additional, DARASTEANU, Iuliana, additional, GIRARD, Pierre-Marie, additional, ALVAREZ, Jean-Claude, additional, MATHEZ, Dominique, additional, DE TRUCHIS, Pierre, additional, LANDMAN, Roland, additional, MEYNARD, Jean-Luc, additional, MORAND-JOUBERT, Laurence, additional, LAMBERT, Sidonie, additional, LE DU, Damien, additional, PERRONNE, Christian, additional, ASSOUMOU, Lambert, additional, COSTAGLIOLA, Dominique, additional, MELCHIOR, Jean-Claude, additional, DURACINSKI, Martin, additional, PETROV-SANCHEZ, Ventzislava, additional, AMAT, Karine, additional, BENALYCHERIF, Aïda, additional, SYLLA, Babacar, additional, GELLEY, Ambre, additional, GIBOWSKI, Séverine, additional, LE MEUT, Guillaume, additional, THIEBAUT, Rodolphe, additional, CLUMECK, Nathan, additional, LECLERCQ, Vincent, additional, CECCHERINI-SILBERSTEIN, Francesca, additional, and DECOSTER, Laurent, additional
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- 2022
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21. History of COVID-19 Symptoms and Seroprevalence of SARS-CoV-2 Antibodies in HIV-Infected Patients in Northern France after the First Wave of the Pandemic
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Meybeck, Agnès, primary, Huleux, Thomas, additional, Tétart, Macha, additional, Thill, Pauline, additional, Derdour, Vincent, additional, Bocket, Laurence, additional, Alidjinou, Enagnon Kazali, additional, Patoz, Pierre, additional, Robineau, Olivier, additional, and Ajana, Faiza, additional
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- 2021
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22. Long-term efficacy and toxicity of abacavir/lamivudine/nevirapine compared to the most prescribed ARV regimens before 2013 in a French Nationwide Cohort Study
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de Boissieu, Paul, Dramé, Moustapha, Raffi, François, Cabie, André, Poizot-Martin, Isabelle, Cotte, Laurent, Garraffo, Rodolphe, Delobel, Pierre, Huleux, Thomas, Rey, David, and Bani-Sadr, Firouzé
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- 2016
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23. No barrier to care, yet disparities in the HIV care continuum in France: a nationwide population study
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Cuzin, Lise, Allavena, Clotilde, Cotte, Laurent, Delpierre, Cyrille, Huleux, Thomas, Palich, Romain, Delobel, Pierre, Raffi, François, Cabié, André, Drobacheff-Thiébaut, C, Foltzer, A, Bouiller, K, Hustache- Mathieu, L, Chirouze, C, Lepiller, Q, Bozon, F, Babre, O, Brunel, L, Muret (Besançon), P, Laurichesse, H, LESENS, O, Vidal, M, Mrozek, N, Aumeran, C, Baud, O, Corbin, V, Letertre-Gibert, P, Casanova, S, Prouteau, J, Jacomet (Clermont Ferrand), C, Lamaury, I, Fabre, I, Curlier, E, Ouissa, R, Herrmann-Storck, C, Tressieres, B, Bonijoly, T, Receveur, M., Boulard, F, Daniel, C, Clavel (Guadeloupe), C, Merrien, D, Perré, P, Guimard, T, Bollangier, O, Leautez, S, Morrier, M, Laine (La Roche sur Yon), L, Ader, F, Becker, A, Biron, F, Boibieux, A, FERRY, T, Miailhes, P, Perpoint, T, Roux, Stéphane, Triffault-Fillit, C, Degroodt, S, Brochier, C, Valour, F, Chidiac (Lyon), C, Ménard, A, Belkhir, A., Colson, P, Dhiver, C, Madrid, A, Martin-Degiovani, M, Meddeb, L, Mokhtari, M, Motte, A, Raoux, A, Ravaux, I, Tamalet, C, Toméi, C, Tissot Dupont, H, Brégigeon, S, Zaegel-Faucher, O, Obry-Roguet, V, Laroche, H, Orticoni, M, Soavi, M., de Lamarlière, P Geneau, Ressiot, E, Ducassou, M., Jaquet, I, Galie, S, Galinier, A, Martinet, P, Landon, M, Ritleng, A., Ivanova, A, Debreux, C, Lions, C, Poizot-Martin (Marseille Ste Marguerite), I, Bigeard, B, Cabras, O, Guitteaud, K, Illiaquer, M, Marquise, A, Pierre-François, S, Pasquier, J, Rome, K, Turmel, J., Varache, C, Cabié (Martinique), A, Atoui, N, Bistoquet, M, Delaporte, E, Le Moing, V, Makinson, A, Meftah, N, de Boever, C Merle, Montes, B, Montoya Ferrer, A, Tuaillon, E, Reynes (Montpellier), J, André, M, Boyer, L, Bouillon, M., Delestan, M, Rabaud, C, May, T, Hoen (Nancy), B, Bernaud, C, Billaud, E, Biron, C, Bonnet, B, Bouchez, S, Boutoille, D, Brunet-Cartier, C, Deschanvres, C, Gaborti, B, Hall, N, Jovelin, T, Morineau, P, Reliquet, V, Sécher, S, Cavellec, M, Soria, A, Ferré, V, André-Garnier, E, Rodallec, A, Lefebvre, M, Grossi, O, Aubry, O, Raffi (Nantes), F, Pugliese, P, Breaud, S, Ceppi, C, Chirio, D, Cua, E, Dellamonica, P, Demonchy, E, De Monte, A, Durant, J, Etienne, C, Ferrando, S, Garraffo, R, Michelangeli, C, Mondain, V, Naqvi, A, Oran, N, Perbost, I, Pillet, S, Pradier, C, Prouvost-Keller, B, Risso, K, Rio, V, Roger, P., Rosenthal, E, Sausse, S, Touitou, I, Wehrlen-Pugliese, S, Zouzou (Nice), G, Hocqueloux, L, Prazuck, T, Gubavu, C, Sève, A, Maka, A, Boulard, C, Thomas, G, Botelho-Nevers, E, Gagneux-Brunon, A, Frésard, A, Ronat, V, Lucht, F, Fischer, P, Partisani, M, Cheneau, C, Priester, M, Batard, M., Bernard-Henry, C, de Mautort, E, Fafi-Kremer, S, Rey, D, Alvarez, M, Biezunski, N, Debard, A, Lansalot, P, Lelièvre, L, Martin-Blondel, G, Piffaut, M, Porte, L, Saune, K, Ajana, F, Aïssi, E, Alcaraz, I, Baclet, V, Bocket, L, Boucher, A, Choisy, P, Lafon-Desmurs, B, Meybeck, A, Pradier, M, Robineau, O, Viget, N, Valette, M, Yazdanpanah, Y, Landman, R, Duvivier, C, Valantin, M., Agher, R, Katlama, C, Flandre, P, Lortholary, O, Avettand-Fenoel, V, Rouzioux, C, Consigny, P., Cessot, G, Touam, F, Usubillaga, R, Benhadj, K, Service de maladies infectieuses et tropicales [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Service des Maladies Infectieuses et Tropicales [Hôpital Gustave Dron, Tourcoing], Centre Hospitalier Gustave Dron [Tourcoing], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Infectious and Tropical Diseases, Nantes University Hospital, Nantes, France., CIC 1413, INSERM, Nantes, France., Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]
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Male ,Microbiology (medical) ,media_common.quotation_subject ,[SDV]Life Sciences [q-bio] ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Men who have sex with men ,MESH: Homosexuality, Male ,Sexual and Gender Minorities ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Pharmacology (medical) ,Prospective Studies ,030212 general & internal medicine ,Homosexuality ,Homosexuality, Male ,Prospective cohort study ,media_common ,Pharmacology ,030505 public health ,MESH: Humans ,business.industry ,MESH: HIV Infections ,Continuity of Patient Care ,Place of birth ,Care Continuum ,MESH: Male ,MESH: Prospective Studies ,3. Good health ,MESH: France ,MESH: Sexual and Gender Minorities ,MESH: Continuity of Patient Care ,Infectious Diseases ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Population study ,Female ,France ,0305 other medical science ,business ,Viral load ,MESH: Female ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Demography - Abstract
Objectives Even in an ‘optimal’ health system, patients’ characteristics may have an impact on their care. We investigated whether age, gender and place of birth have an impact in the HIV care continuum in France, a country with a universal free healthcare system. Methods We estimated differences in the 5 year restricted mean percentage of person-time spent (i) in care, (ii) receiving ART and (iii) on ART and virally suppressed among 2432 (30.2%) women, 3925 MSM (48.7%) and 1709 men who have sex with women (MSW; 21.2%) entering care in the Dat’AIDS French prospective cohort between 1 January 2013 and 31 December 2017. Trial registration: Clinicaltrials.gov reference NCT02898987. Results Men and women spent 85.6% and 82.8% of person-time on ART and 69.9% and 65% suppressed, respectively. MSM, MSW and women spent 86.9%, 82.6% and 82.8% of person-time on ART and 72.5%, 63.7% and 65% suppressed, respectively. Patients born in France (47%) and patients born abroad spent 87.9% and 81.9% of person-time on ART and 74.6% and 62.9% suppressed, respectively. Young men born abroad were found to spend the smallest person-time with non-detectable viral load (53% for MSW and 58.1% for MSM). Conclusions Despite free access to care and universal ART in France, disparities remain in the HIV continuum care across age, country of birth and way of HIV acquisition. Clinical and public health interventions targeting specific patients’ conditions are needed.
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- 2021
24. Assessment of intra-sample variability in HIV-1 DNA drug resistance genotyping
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Millière, Laurine, primary, Bocket, Laurence, additional, Tinez, Claire, additional, Robineau, Olivier, additional, Veyer, Nathalie, additional, Wojciechowski, Fanny, additional, Lambert, Valérie, additional, Meybeck, Agnès, additional, Huleux, Thomas, additional, Ajana, Faiza, additional, Hober, Didier, additional, and Alidjinou, Enagnon Kazali, additional
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- 2021
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25. Spectrum and Incidence Trends of AIDS- and Non–AIDS-Defining Cancers between 2010 and 2015 in the French Dat'AIDS Cohort
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Poizot-Martin, Isabelle, primary, Lions, Caroline, additional, Allavena, Clotilde, additional, Huleux, Thomas, additional, Bani-Sadr, Firouze, additional, Cheret, Antoine, additional, Rey, David, additional, Duvivier, Claudine, additional, Jacomet, Christine, additional, Ferry, Tristan, additional, Cabie, André, additional, Fresard, Anne, additional, Pugliese, Pascal, additional, Delobel, Pierre, additional, Lamaury, Isabelle, additional, Chirouze, Catherine, additional, Zaegel-Faucher, Olivia, additional, Brégigeon, Sylvie, additional, Rojas Rojas, Teresa, additional, Obry-Roguet, Véronique, additional, and Makinson, Alain, additional
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- 2021
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26. Microelimination or Not? The Changing Epidemiology of Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in France 2012-2018
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Pradat, Pierre, Chirouze, C, Drobacheff-Thiébaut, C, Foltzer, A, Bouiller, K, Hustache-Mathieu, L, Lepiller, Q, Bozon, F, Babre, O, Brunel, A, Muret, P, Chevalier, E, Jacomet, C, Laurichesse, H, LESENS, O, Vidal, M, Mrozek, N, Aumeran, C, Baud, O, Corbin, V, Goncalvez, E, Mirand, A, brebion, A, Henquell, C, Lamaury, I, Fabre, I, Curlier, E, Ouissa, R, Herrmann-Storck, C, Tressieres, B, Receveur, M, Boulard, F, Daniel, C, CLAVEL, C, Roger, P, Markowicz, S, Chellum Rungen, N, Merrien, D, Perré, P, Guimard, T, Bollangier, O, Leautez, S, Morrier, M, Laine, L, Boucher, D, Point, P, Cotte, Laurent, Ader, F, Becker, A, Boibieux, A, Brochier, C, Brunel-Dalmas, F, Cannesson, O, Chiarello, P, Chidiac, C, Degroodt, S, FERRY, T, Godinot, M, Livrozet, J, Makhloufi, D, Miailhes, P, Perpoint, T, Perry, M, Pouderoux, C, Roux, Stéphane, Triffault-Fillit, C, Valour, F, Charre, C, Icard, V, Tardy, J, Trabaud, M, Ravaux, I, Ménard, A, Belkhir, A, Colson, P, Dhiver, C, Madrid, A, Martin-Degioanni, M, Meddeb, L, Mokhtari, M, Motte, A, Raoux, A, Toméi, C, Tissot-Dupont, H, Poizot-Martin, Isabelle, Brégigeon, S, Zaegel-Faucher, O, Obry-Roguet, V, Laroche, H, Orticoni, M, Soavi, M, Ressiot, E, Ducassou, M, Jaquet, I, Galie, S, Colson, H, Ritleng, A, Ivanova, A, Debreux, C, Lions, C, Rojas-Rojas, T, Cabié, André, Abel, S, Bavay, J, Bigeard, B, Cabras, O, Cuzin, L, Dupin de Majoubert, R, Fagour, L, Guitteaud, K, Marquise, A, Najioullah, F, Pierre-François, S, Pasquier, J, Richard, P, Rome, K, Turmel, J, Varache, C, Atoui, N, Bistoquet, M, Delaporte, E, Le Moing, V, Makinson, A, Meftah, N, Merle de Boever, C, Montes, B, Montoya Ferrer, A, Tuaillon, E, Reynes, J, Lefèvre, B, Jeanmaire, E, Hénard, S, Frentiu, E, Charmillon, A, Legoff, A, Tissot, N, André, M, Boyer, L, Bouillon, M, Delestan, M, Goehringer, F, Bevilacqua, S, Rabaud, C, May, T, Raffi, F, Allavena, C, Aubry, O, Billaud, E, Biron, C, Bonnet, B, Bouchez, S, Boutoille, D, Brunet-Cartier, C, Deschanvres, C, Gaborit, B, Grégoire, A, Grégoire, M, Grossi, O, Guéry, R, Lefebvre, Maeva, Le Turnier, P, Lecomte, R, Morineau, P, Reliquet, V, Sécher, S, Cavellec, M, Paredes, E, Soria, A, Ferré, V, André-Garnier, E, Rodallec, A, Pugliese, Pascal, Breaud, S, Ceppi, C, Chirio, D, Cua, E, Dellamonica, P, Demonchy, E, De Monte, A, Durant, J, Etienne, C, Ferrando, S, Garraffo, R, Michelangeli, C, Mondain, V, Naqvi, A, Oran, N, Perbost, I, Carles, M, Klotz, C, Maka, A, Pradier, C, Prouvost-Keller, B, Risso, K, Rio, V, Rosenthal, E, Touitou, I, Wehrlen-Pugliese, S, Zouzou, G, Hocqueloux, Laurent, Prazuck, T, Gubavu, C, Sève, A, Giaché, S, Rzepecki, V, Colin, M, Boulard, C, Thomas, G, Cheret, A, Goujard, C, Quertainmont, Y, Teicher, E, Lerolle, N, Jaureguiberry, S, Colarino, R, Deradji, O, Castro, A, Barrail-Tran, A, Yazdanpanah, Y, Landman, R, Joly, V, Ghosn, J, Rioux, C, Lariven, S, gervais, a, Lescure, F, Matheron, S, Louni, F, Julia, Z, Le Gac, S, Charpentier, c, Descamps, D, Peytavin, G, Duvivier, C, Aguilar, C, Alby-Laurent, F, Amazzough, K, Benabdelmoumen, G, Bossi, P, Cessot, G, Charlier, C, Consigny, P, Jidar, K, Lafont, E, Lanternier, F, Leporrier, J, Lortholary, O, Louisin, C, Lourenco, J, Parize, P, Pilmis, B, Rouzaud, C, Touam, F, Valantin, M, Tubiana, R, Agher, R, Seang, S, Schneider, L, PaLich, R, Blanc, C, Katlama, C, Bani-Sadr, Firouze, Berger, J, N’Guyen, Y, Lambert, D, Kmiec, I, Hentzien, M, Brunet, A, Romaru, J, Marty, H, Brodard, V, Arvieux, C, Tattevin, P, Revest, M, Souala, F, Baldeyrou, M, Patrat-Delon, S, Chapplain, J, Benezit, F, Dupont, M, Poinot, M, MAILLARD, A, Pronier, C, Lemaitre, F, Morlat, C, Poisson-Vannier, M, Jovelin, T, Sinteff, J, Gagneux-Brunon, A, Botelho-Nevers, E, Frésard, A, Ronat, V, Lucht, F, Rey, David, Fischer, P, Partisani, M, Cheneau, C, Priester, M, Mélounou, C, Bernard-Henry, C, de Mautort, E, Fafi-Kremer, S, Delobel, P, Alvarez, M, Biezunski, N, Debard, A, Delpierre, C, Gaube, G, Lansalot, P, Lelièvre, L, Marcel, M, Martin-Blondel, G, Piffaut, M, Porte, L, Saune, K, Robineau, O, Ajana, F, Aïssi, E, Alcaraz, I, Alidjinou, E, Baclet, V, Bocket, L, Boucher, A, Digumber, M, Huleux, Thomas, Lafon-Desmurs, B, Meybeck, A, Pradier, M, Tetart, M, Thill, P, Viget, N, Valette, M, Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Régional d'Orléans (CHRO), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital universitaire Robert Debré [Reims], Centre Hospitalier Gustave Dron [Tourcoing], Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Aix Marseille Université (AMU), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital l'Archet, Les Hôpitaux Universitaires de Strasbourg (HUS), Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Université des Antilles (UA), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Dat’AIDS Study Group Besançon: C. Chirouze, C. Drobacheff-Thiébaut, A. Foltzer, K. Bouiller, L. Hustache- Mathieu, Q. Lepiller, F. Bozon, O. Babre, AS. Brunel, P. Muret, E. Chevalier. Clermont-Ferrand: C. Jacomet, H. Laurichesse, O. Lesens, M. Vidal, N. Mrozek, C. Aumeran, O. Baud, V. Corbin, E. Goncalvez, A Mirand, A brebion, C Henquell. Guadeloupe: I. Lamaury, I. Fabre, E. Curlier, R. Ouissa, C. Herrmann-Storck, B. Tressieres, MC. Receveur, F. Boulard, C. Daniel, C. Clavel, PM. Roger, S. Markowicz, N. Chellum Rungen. La Roche sur Yon: D. Merrien, P. Perré, T. Guimard, O. Bollangier, S. Leautez, M. Morrier, L. Laine, D. Boucher, P. Point. Lyon: L. Cotte, F. Ader, A. Becker, A. Boibieux, C. Brochier F, Brunel-Dalmas, O. Cannesson, P. Chiarello, C. Chidiac, S. Degroodt, T. Ferry, M. Godinot, J.M. Livrozet, D. Makhloufi, P. Miailhes, T. Perpoint, M. Perry, C. Pouderoux, S. Roux, C. Triffault-Fillit, F. Valour, C. Charre, V. Icard, J.C. Tardy, M.A. Trabaud. Marseille IHU Méditerrannée: I. Ravaux, A. Ménard, AY. Belkhir, P. Colson, C. Dhiver, A. Madrid, M. Martin-Degioanni, L. Meddeb, M. Mokhtari, A. Motte, A. Raoux, C. Toméi, H. Tissot-Dupont. Marseille Ste Marguerite: I. Poizot-Martin, S. Brégigeon, O. Zaegel-Faucher, V. Obry-Roguet, H Laroche, M. Orticoni, M.J. Soavi, E. Ressiot, M.J. Ducassou, I. Jaquet, S. Galie, H. Colson, A.S. Ritleng, A. Ivanova, C. Debreux, C. Lions, T Rojas-Rojas. Martinique: A. Cabié, S. Abel, J. Bavay, B. Bigeard, O. Cabras, L. Cuzin, R. Dupin de Majoubert, L. Fagour, K. Guitteaud, A. Marquise, F. Najioullah, S. Pierre-François, J. Pasquier, P. Richard, K. Rome, JM Turmel, C. Varache. Montpellier: N. Atoui, M. Bistoquet, E Delaporte, V. Le Moing, A. Makinson, N. Meftah, C. Merle de Boever, B. Montes, A. Montoya Ferrer, E. Tuaillon, J. Reynes. Nancy: B. Lefèvre, E. Jeanmaire, S. Hénard, E. Frentiu, A. Charmillon, A. Legoff, N. Tissot, M. André, L. Boyer, MP. Bouillon, M. Delestan, F. Goehringer, S. Bevilacqua, C. Rabaud, T. May. Nantes: F. Raffi, C. Allavena, O. Aubry, E. Billaud, C. Biron, B. Bonnet, S. Bouchez, D. Boutoille, C. Brunet-Cartier, C. Deschanvres, B.J. Gaborit, A. Grégoire, M. Grégoire, O. Grossi, R. Guéry, T. Jovelin, M. Lefebvre, P. Le Turnier, R. Lecomte, P. Morineau, V. Reliquet, S. Sécher, M. Cavellec, E. Paredes, A. Soria, V. Ferré, E. André-Garnier, A. Rodallec. Nice: P. Pugliese, S. Breaud, C. Ceppi, D. Chirio, E. Cua, P. Dellamonica, E. Demonchy, A. De Monte, J. Durant, C. Etienne, S. Ferrando, R. Garraffo, C. Michelangeli, V. Mondain, A. Naqvi, N. Oran, I. Perbost, M. Carles, C. Klotz, A. Maka, C. Pradier, B. Prouvost- Keller, K. Risso, V. Rio, E. Rosenthal, I. Touitou, S. Wehrlen-Pugliese, G. Zouzou. Orléans: L. Hocqueloux, T. Prazuck, C. Gubavu, A. Sève, S. Giaché, V. Rzepecki, M. Colin, C. Boulard, G. Thomas. Paris APHP Bicètre: A. Cheret, C. Goujard, Y. Quertainmont, E. Teicher, N. Lerolle, S. Jaureguiberry, R. Colarino, O. Deradji, A. Castro, A. Barrail-Tran. Paris APHP Bichat: Y. Yazdanpanah, R. Landman, V. Joly, J. Ghosn, C. Rioux, S. Lariven, A. Gervais, FX. Lescure, S. Matheron, F. Louni, Z. Julia, S. Le GAC, C. Charpentier, D. Descamps, G. Peytavin. Paris APHP Necker Pasteur: C. Duvivier, C. Aguilar, F. Alby-Laurent, K. Amazzough, G. Benabdelmoumen, P. Bossi, G. Cessot, C. Charlier, P.H. Consigny, K. Jidar, E. Lafont, F. Lanternier, J. Leporrier, O. Lortholary, C. Louisin, J. Lourenco, P. Parize, B. Pilmis, C. Rouzaud, F. Touam. Paris APHP Pitié Salpetrière: MA. Valantin, R. Tubiana, R. Agher, S. Seang, L. Schneider, R. PaLich, C. Blanc, C. Katlama. Reims: F. Bani-Sadr, JL. Berger, Y. N’Guyen, D. Lambert, I. Kmiec, M. Hentzien, A. Brunet, J. Romaru, H. Marty, V. Brodard. Rennes: C. Arvieux, P. Tattevin, M. Revest, F. Souala, M. Baldeyrou, S. Patrat-Delon, J.M. Chapplain, F. Benezit, M. Dupont, M. Poinot, A. Maillard, C. Pronier, F. Lemaitre, C. Morlat, M. Poisson-Vannier, T. Jovelin, JP. Sinteff. St Etienne: A. Gagneux-Brunon, E. Botelho-Nevers, A. Frésard, V. Ronat, F. Lucht. Strasbourg: D. Rey, P. Fischer, M. Partisani, C. Cheneau, M. Priester, C. Mélounou, C. Bernard-Henry, E. de Mautort, S. Fafi-Kremer. Toulouse: P. Delobel, M. Alvarez, N. Biezunski, A. Debard, C. Delpierre, G. Gaube, P. Lansalot, L. Lelièvre, M. Marcel, G. Martin-Blondel, M. Piffaut, L. Porte, K. Saune. Tourcoing: O. Robineau, F. Ajana, E. Aïssi, I. Alcaraz, E. Alidjinou, V. Baclet, L. Bocket, A. Boucher, M. Digumber, T. Huleux, B. Lafon-Desmurs, A. Meybeck, M. Pradier, M. Tetart, P. Thill, N. Viget, M. Valette., CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), and Malbec, Odile
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Microbiology (medical) ,Male ,medicine.medical_specialty ,Hepatitis C virus ,[SDV]Life Sciences [q-bio] ,Population ,men having sex with men ,HIV Infections ,Hepacivirus ,medicine.disease_cause ,Antiviral Agents ,Men who have sex with men ,03 medical and health sciences ,Sexual and Gender Minorities ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Human Immunodeficiency virus ,Homosexuality, Male ,education ,Retrospective Studies ,Hepatitis ,education.field_of_study ,business.industry ,Coinfection ,Mortality rate ,Incidence (epidemiology) ,microelimination ,virus diseases ,HIV ,Hepatitis C, Chronic ,medicine.disease ,Hepatitis C ,digestive system diseases ,3. Good health ,[SDV] Life Sciences [q-bio] ,Infectious Diseases ,Cohort ,030211 gastroenterology & hepatology ,epidemiology ,France ,business - Abstract
Background The arrival of highly effective, well-tolerated, direct-acting antiviral agents (DAA) led to a dramatic decrease in hepatitis C virus (HCV) prevalence. Human immunodeficiency virus (HIV)-HCV–coinfected patients are deemed a priority population for HCV elimination, while a rise in recently acquired HCV infections in men who have sex with men (MSM) has been described. We describe the variations in HIV-HCV epidemiology in the French Dat’AIDS cohort. Methods This was a retrospective analysis of a prospective cohort of persons living with HIV (PLWH) from 2012 to 2018. We determined HCV prevalence, HCV incidence, proportion of viremic patients, treatment uptake, and mortality rate in the full cohort and by HIV risk factors. Results From 2012 to 2018, 50 861 PLWH with a known HCV status were followed up. During the period, HCV prevalence decreased from 15.4% to 13.5%. HCV prevalence among new HIV cases increased from 1.9% to 3.5% in MSM but remained stable in other groups. Recently acquired HCV incidence increased from 0.36/100 person-years to 1.25/100 person-years in MSM. The proportion of viremic patients decreased from 67.0% to 8.9%. MSM became the first group of viremic patients in 2018 (37.9%). Recently acquired hepatitis represented 59.2% of viremic MSM in 2018. DAA treatment uptake increased from 11.4% to 61.5%. More treatments were initiated in MSM in 2018 (41.2%) than in intravenous drug users (35.6%). In MSM, treatment at the acute phase represented 30.0% of treatments in 2018. Conclusions A major shift in HCV epidemiology was observed in PLWH in France from 2012 to 2018, leading to a unique situation in which the major group of HCV transmission in 2018 was MSM. Clinical Trials Registration. NCT02898987.
- Published
- 2020
27. Kaposi sarcoma among people living with HIV in the French DAT'AIDS cohort between 2010 and 2015
- Author
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Obry-Roguet, Véronique, Duvivier, Claudine, Lions, Caroline, Huleux, Thomas, Jacomet, Christine, Ferry, Tristan, Cheret, Antoine, Allavena, Clotilde, Bani-Sadr, Firouzé, Palich, Romain, Cabié, André, Pugliese, Pascal, Delobel, Pierre, Lamaury, Isabelle, Hustache-Mathieu, Laurent, Bregigeon, Sylvie, Makinson, Alain, Rey, David, Poizot-Martin, Isabelle, Hustache‐Mathieu, Laurent, Drobacheff‐Thiébaut, C., Foltzer, A., Bouiller, K., Hustache‐ Mathieu, L., Chirouze, C., LEPILLER, Q., Bozon, F., Babre, O, Brunel, A.S., Muret, P., Laurichesse, H., Lesens, O., Vidal, M., Mrozek, N., Aumeran, C., Baud, O., Corbin, V., Letertre‐Gibert, P., Casanova, S., Prouteau, J., Fabre, I., Curlier, E., Ouissa, R., Herrmann‐Storck, C., Tressieres, B., Bonijoly, T., Receveur, M.C., Boulard, F., Daniel, C., Clavel, C., Merrien, D., Perré, P., Guimard, T., Bollangier, O., Leautez, S., Morrier, M., Laine, L., Ader, F., Becker, A., Biron, F., Boibieux, A., Cotte, L., Miailhes, P., Perpoint, T., Roux, S., Triffault‐Fillit, C., Degroodt, S., Brochier, C., Valour, F., Chidiac, C., Ménard, A., Belkhir, A.Y., Colson, P., Dhiver, C., Madrid, A., Martin‐Degioanni, M., Meddeb, L., Mokhtari, M., Motte, A., Raoux, A., Ravaux, I., Tamalet, C., Tomei, C., Tissot Dupont, H., Zaegel‐Faucher, O., Obry‐Roguet, Véronique, Laroche, H, Orticoni, M., Soavi, M.J., Geneau de Lamarlière, P, Ressiot, E, Ducassou, M.J., Jaquet, I., Galie, S., Galinier, A., Martinet, P., Landon, M., Ritleng, A.S., Ivanova, A., Debreux, C., Poizot‐Martin, I., Abel, S., Cabras, O., Cuzin, L., Guitteaud, K., Illiaquer, M., Pierre‐François, S., Osei, L., Pasquier, J., Rome, K., Sidani, E., Turmel, JM, Varache, C., Atoui, N., Bistoquet, M., Delaporte, E., Le Moing, V., Meftah, N., Merle de Boever, C., Montes, B., Montoya Ferrer, A., Tuaillon, E., Reynes, J., André, M., Boyer, L., Bouillon, MP., Delestan, M., Rabaud, C., May, T., Hoen, B., Bernaud, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, S., Boutoille, D., Brunet‐Cartier, C., Deschanvres, C., Hall, N., Morineau, P., Reliquet, V., Sécher, S., Cavellec, M., Soria, A., Paredes, E., Ferre, V., André‐Garnier, E., Rodallec, A., Lefebvre, M., Grossi, O., Aubry, O., Raffi, F., Breaud, S., Ceppi, C., Chirio, D., Cua, E., Dellamonica, P., Demonchy, E., De Monte, A., Durant, J., Etienne, C., Ferrando, S., Garraffo, R., Michelangeli, C., Mondain, V., Naqvi, A., Oran, N., Perbost, I., Pillet, S., Pradier, C., Prouvost‐Keller, B., Risso, K., Rio, V., Roger, PM., Rosenthal, E., Sausse, S., Touitou, I., Wehrlen‐Pugliese, S., Zouzou, G., Hocqueloux, L., Prazuck, T., Gubavu, C., Sève, A., Maka, A., Boulard, C., Thomas, G., Lerolle, N., Landman, R., Joly, V., Ghosn, J., Rioux, C., Lariven, S., Gervais, A., Lescure, F.X., Matheron, S., Louni, F., Julia, Z., Mackoumbou‐Nkouka, C., Le Gac, S., Charpentier, C., Descamps, D., Peytavin, G., Yazdanpanah, Y., Amazzough, K., Benabdelmoumen, G., Bossi, P., Cessot, G., Charlier, C., Consigny, P.H., Danion, F., Dureault, A., Goesch, J., Guery, R., Henry, B., Jidar, K., Lanternier, F., Loubet, P., Lortholary, O., Louisin, C., Lourenco, J., Parize, P., Pilmis, B., Touam, F, Valantin, M.A., Tubiana, R., Agher, R, Seang, S., Schneider, L., Blanc, C., Katlama, C., Berger, J.L., N'guyen, Y., Lambert, D., Kmiec, I., Hentzien, M., Brunet, A., Brodard, V., Bani‐Sadr, Firouze, Tattevin, P., Revest, M., Souala, F., Baldeyrou, M., Patrat‐Delon, S., Chapplain, J.M., Bénézit, F., Dupont, M., Poinot, M., Maillard, A., Pronier, C., Lemaitre, F., Guennoun, C., Poisson‐Vanier, M., Jovelin, T., Sinteff, J.P., Arvieux, C., Botelho‐Nevers, E., Gagneux‐Brunon, A., Frésard, Anne, Ronat, V., Lucht, F., Fischer, P., Partisani, M., Cheneau, C., Priester, M, Batard, ML, Bernard‐Henry, C, de Mautort, E, Fafi‐Kremer, S., Alvarez, M., Biezunski, N., Debard, A., Delpierre, C., Lansalot, P., Lelievre, L., Martin‐Blondel, G., Piffaut, M., Porte, L., Saune, K., Ajana, F., Aïssi, E., Alcaraz, I., Baclet, V., Bocket, L., Boucher, A., Choisy, P., Lafon‐Desmurs, B., Meybeck, A., Pradier, M., Robineau, O., Viget, N., Valette, M., Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Centre d'infectiologie Necker-Pasteur [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Tourcoing, Département des Maladies Infectieuses et Tropicales [CHU Gabriel-Montpied, Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], Pathogénie des Staphylocoques – Staphylococcal Pathogenesis, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Services des maladies infectieuses [CH Turcoing], Centre Hospitalier de Tourcoing, Service de maladies infectieuses et tropicales [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Universitaire de Reims (CHU Reims), Alliance for International medical Action (ALIMA), Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique], CHU de la Martinique [Fort de France]-Hôpital Pierre Zobda-Quitman [CHU de la Martinique], CHU de la Martinique [Fort de France]-Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service de Maladies Infectieuses [Nice], Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pointe-à-Pitre/Abymes [Guadeloupe], service de maladies infectieuses CHU J Minjoz Besancon, Hôpital Jean Minjoz, Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Universtié Yaoundé 1 [Cameroun]-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Laboratoire d'Ingénierie Circulation Transport (LICIT), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-École Nationale des Travaux Publics de l'État (ENTPE)-Université de Lyon, Laboratoire Chrono-environnement - CNRS - UFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Universitaire de Besançon (CHU Besançon), Université libre de Bruxelles (ULB), Hôpital Gabriel Montpied, Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Clermont-Ferrand, Laboratoire Microorganismes : Génome et Environnement - Clermont Auvergne (LMGE), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), CHU Gabriel Montpied (CHU), CHU Clermont-Ferrand, CCLIN Sud-Est – Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est, Montpellier Research in Management (MRM), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Perpignan Via Domitia (UPVD)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université de Montpellier (UM), Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hosp Civils Lyon, Serv Malad Infect, Lyon, France, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Equipe 15, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon], Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Institut Hospitalier Universitaire Méditerranée Infection (IHU AMU), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie, plasticité tissulaire et métabolisme énergétique (NPTME), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), CECIL, Space Research Institute of the Russian Academy of Sciences (IKI), Russian Academy of Sciences [Moscow] (RAS), Système membranaires, photobiologie, stress et détoxication (SMPSD), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre IRD de Montpellier (IRD), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Bell Labs (BELL), Lucent Technologies, Service des maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Hôpital Saint-Jacques, Centre hospitalier universitaire de Nantes (CHU Nantes), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Service des maladies infectieuses et tropicales [CHU Nantes], Plant Biomechanics Group, Botanischer Garten, Albert-Ludwigs-Universität Freiburg, Service de virologie [CHU Nantes], Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service des maladies infectieuses, Centre Hospitalier Universitaire de Nice (CHU Nice)-University Hospital, CHU Nice [Cimiez], Hôpital Cimiez [Nice] (CHU), Centre Hospitalier Universitaire de Nice (CHU Nice), Hopital l'Archet, Centre d'Information et de Soins de I'Immunodéficience Humaine (CISIH). Hôpital l'Archet 1, Hôpital l'Archet, Public Health Department, Hôpital de l'Archet, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, Infectious Diseases Department, Université Montpellier 1 (UM1), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Régional de recherche et de Formation à la prise en charge Clinique de Fann (CRCF), CHNU Fann, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d'Etudes Lasers Intenses et Applications (CELIA), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB), Pharmacie de l'Hôpital Bichat, UMR CNRS 8179, Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Pathogénie des infections systémiques (UMR_S 570), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses [CHU Pitié-Salêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Laboratoire d'aérologie (LA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Service des maladies infectieuses et réanimation médicale, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Les Hôpitaux Universitaires de Strasbourg (HUS), Service de pneumologie, Hôpital Pontchaillou-CHU Pontchaillou [Rennes], CHU Pontchaillou [Rennes], SEV, Groupe d'Etudes et de Contrôle des Variétés et des Semences (GEVES), Service de virologie [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), University Hospital and University Jean Monnet, Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Virologie et pathogenèse virale (VPV), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP), Centre Hospitalier Gustave Dron [Tourcoing], Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) (EA 7327), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Département d'Hématologie Clinique [CHU Nantes] (Hôtel-Dieu), Hôtel-Dieu de Nantes-Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Robert Debré, Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Maladies infectieuses et tropicales dans la Caraïbe (MAITC EA 4537), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Université des Antilles (UA), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre de Physiopathologie Toulouse Purpan (CPTP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service Maladies infectieuses et tropicales [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Dermatologie et Maladies infectieuses [Pointe-à-Pitre], CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre de Gestion du Risque Infectieux Nosocomial [Pointe-à-Pitre] (CGRIN), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Infectious and Tropical Diseases Department [Montpellier], Institut de Recherche pour le Développement (IRD)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dat'AIDS study group: C Drobacheff-Thiébaut, A Foltzer, K Bouiller, C Chirouze, Q Lepiller, F Bozon, O Babre, A S Brunel, P Muret, H Laurichesse, O Lesens, M Vidal, N Mrozek, C Aumeran, O Baud, V Corbin, P Letertre-Gibert, S Casanova, J Prouteau, I Fabre, E Curlier, R Ouissa, C Herrmann-Storck, B Tressieres, T Bonijoly, M C Receveur, F Boulard, C Daniel, C Clavel, D Merrien, P Perré, T Guimard, O Bollangier, S Leautez, M Morrier, L Laine, F Ader, A Becker, F Biron, A Boibieux, L Cotte, P Miailhes, T Perpoint, S Roux, C Triffault-Fillit, S Degroodt, C Brochier, F Valour, C Chidiac, A Ménard, A Y Belkhir, P Colson, C Dhiver, A Madrid, M Martin-Degioanni, L Meddeb, M Mokhtari, A Motte, A Raoux, I Ravaux, C Tamalet, C Toméi, H Tissot Dupont, O Zaegel-Faucher, H Laroche, M Orticoni, M J Soavi, P Geneau de Lamarlière, E Ressiot, M J Ducassou, I Jaquet, S Galie, A Galinier, P Martinet, M Landon, A S Ritleng, A Ivanova, C Debreux, S Abel, O Cabras, L Cuzin, K Guitteaud, M Illiaquer, S Pierre-François, L Osei, J Pasquier, K Rome, E Sidani, J M Turmel, C Varache, N Atoui, M Bistoquet, E Delaporte, V Le Moing, N Meftah, C Merle de Boever, B Montes, A Montoya Ferrer, E Tuaillon, J Reynes, M André, L Boyer, M P Bouillon, M Delestan, C Rabaud, T May, B Hoen, C Bernaud, E Billaud, C Biron, B Bonnet, S Bouchez, D Boutoille, C Brunet-Cartier, C Deschanvres, N Hall, T Jovelin, P Morineau, V Reliquet, S Sécher, M Cavellec, A Soria, E Paredes, V Ferré, E André-Garnier, A Rodallec, M Lefebvre, O Grossi, O Aubry, F Raffi, S Breaud, C Ceppi, D Chirio, E Cua, P Dellamonica, E Demonchy, A De Monte, J Durant, C Etienne, S Ferrando, R Garraffo, C Michelangeli, V Mondain, A Naqvi, N Oran, I Perbost, S Pillet, C Pradier, B Prouvost-Keller, K Risso, V Rio, P M Roger, E Rosenthal, S Sausse, I Touitou, S Wehrlen-Pugliese, G Zouzou, L Hocqueloux, T Prazuck, C Gubavu, A Sève, A Maka, C Boulard, G Thomas, C Goujard, Y Quertainmont, E Teicher, N Lerolle, O Deradji, A Barrail-Tran, R Landman, V Joly, J Ghosn, C Rioux, S Lariven, A Gervais, F X Lescure, S Matheron, F Louni, Z Julia, C Mackoumbou-Nkouka, S Le Gac, C Charpentier, D Descamps, G Peytavin, Y Yazdanpanah, K Amazzough, G Benabdelmoumen, P Bossi, G Cessot, C Charlier, P H Consigny, F Danion, A Dureault, J Goesch, R Guery, B Henry, K Jidar, F Lanternier, P Loubet, O Lortholary, C Louisin, J Lourenco, P Parize, B Pilmis, F Touam, M A Valantin, R Tubiana, R Agher, S Seang, L Schneider, C Blanc, C Katlama, J L Berger, Y N'Guyen, D Lambert, I Kmiec, M Hentzien, A Brunet, V Brodard, P Tattevin, M Revest, F Souala, M Baldeyrou, S Patrat-Delon, J M Chapplain, F Benezit, M Dupont, M Poinot, A Maillard, C Pronier, F Lemaitre, C Guennoun, M Poisson-Vanier, T Jovelin, J P Sinteff, C Arvieux, E Botelho-Nevers, A Gagneux-Brunon, A Frésard, V Ronat, F Lucht, P Fischer, M Partisani, C Cheneau, M Priester, M L Batard, C Bernard-Henry, E de Mautort, S Fafi-Kremer, M Alvarez, N Biezunski, A Debard, C Delpierre, P Lansalot, L Lelièvre, G Martin-Blondel, M Piffaut, L Porte, K Saune, F Ajana, E Aïssi, I Alcaraz, V Baclet, L Bocket, A Boucher, P Choisy, B Lafon-Desmurs, A Meybeck, M Pradier, O Robineau, N Viget, M Valette., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut Pasteur [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Pasteur [Paris], Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Perpignan Via Domitia (UPVD)-Université Montpellier 1 (UM1)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université de Montpellier (UM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, and Dupuis, Christine
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0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,MESH: Sarcoma, Kaposi* / epidemiology ,[SDV]Life Sciences [q-bio] ,030106 microbiology ,HIV Infections ,Dermatology ,Skin Infectiology, Venereology and Sexual Health ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,MESH: HIV Infections* / complications ,030212 general & internal medicine ,Sarcoma, Kaposi ,Retrospective Studies ,Response rate (survey) ,MESH: Acquired Immunodeficiency Syndrome ,MESH: Herpesvirus 8, Human ,Acquired Immunodeficiency Syndrome ,MESH: Humans ,business.industry ,Kaposi sarcoma ,HIV ,Retrospective cohort study ,MESH: Retrospective Studies ,MESH: HIV Infections* / drug therapy ,medicine.disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,medical dermatology ,Regimen ,Infectious Diseases ,Clinical research ,clinical research ,Herpesvirus 8, Human ,Cohort ,oncology ,Original Article ,Sarcoma ,business ,Viral load ,MESH: HIV Infections* / epidemiology ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Background - Although antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV-infected people. Objective - To describe all KS cases observed between 2010 and 2015 in a country with high ART coverage. Methods - Retrospective study using longitudinal data from 44 642 patients in the French Dat'AIDS multicenter cohort. Patients' characteristics were described at KS diagnosis according to ART exposure and to HIV-plasma viral load (HIV-pVL) (≤50 or >50) copies/mL. Results - Among the 209 KS cases diagnosed during the study period, 33.2% occurred in ART naïve patients, 17.3% in ART-experienced patients and 49.5% in patients on ART, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had HIV-pVL ≤50 cp/mL, and 16 (66%) were treated with a boosted-PI-based regimen. The distribution of KS localization did not differ by ART status nor by year of diagnosis. Limitations - Data on human herpesvirus 8, treatment modalities for KS and response rate were not collected. Conclusion - Half of KS cases observed in the study period occurred in patients not on ART, reflecting the persistence of late HIV diagnosis. Factors associated with KS in patients on ART with HIV-pVL ≤50 cp/mL remain to be explored.
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- 2020
28. Virological Outcome After Choice of Antiretroviral Regimen Guided by Proviral HIV-1 DNA Genotyping in a Real-Life Cohort of HIV-Infected Patients
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Meybeck, Agnès, primary, Alidjinou, Enagnon Kazali, additional, Huleux, Thomas, additional, Boucher, Anne, additional, Tetart, Macha, additional, Choisy, Philippe, additional, Bocket, Laurence, additional, Ajana, Faiza, additional, and Robineau, Olivier, additional
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- 2020
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29. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial
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Antoni, Guillemette, primary, Tremblay, Cécile, additional, Delaugerre, Constance, additional, Charreau, Isabelle, additional, Cua, Eric, additional, Rojas Castro, Daniela, additional, Raffi, François, additional, Chas, Julie, additional, Huleux, Thomas, additional, Spire, Bruno, additional, Capitant, Catherine, additional, Cotte, Laurent, additional, Meyer, Laurence, additional, Molina, Jean-Michel, additional, Aboulker, Jean-Pierre, additional, Bajos, Nathalie, additional, Baril, Jean-Guy, additional, Besnier, Michel, additional, Binesse, Johan, additional, Carette, Diane, additional, Cattin, Grégoire, additional, Chéret, Antoine, additional, Chidiac, Christian, additional, Choucair, Elias, additional, Delfraissy, Jean-François, additional, Demoulin, Baptiste, additional, Diallo, Alpha, additional, Durant-Zaleski, Isabelle, additional, Doré, Véronique, additional, Etien, Nicolas, additional, Euphrasie, Françoise, additional, Fonsart, Julien, additional, Foubert, Valérie, additional, Gibowski, Séverine, additional, Girard, Gabriel, additional, Guillon, Brigitte, additional, Le Mestre, Soizic, additional, Lert, France, additional, Leturque, Nicolas, additional, Lorente, Nicolas, additional, Mennecier, Anaïs, additional, Morin, Michel, additional, Netzer, Emmanuelle, additional, Otis, Joanne, additional, Pasquet, Armelle, additional, Peytavin, Gilles, additional, Pialoux, Gilles, additional, Préau, Marie, additional, Rabian, Cécile, additional, Rozenbaum, Willy, additional, Sagaon-Teyssier, Luis, additional, Saïdi, Yacine, additional, Saouzanet, Marine, additional, Simon, Marie-Christine, additional, Suzan-Monti, Marie, additional, Thompson, David, additional, Timsit, Julie, additional, Trottier, Benoît, additional, and Wainberg, Mark, additional
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- 2020
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30. Microelimination or Not? The Changing Epidemiology of Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in France 2012–2018.
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Cotte, Laurent, Hocqueloux, Laurent, Lefebvre, Maeva, Pradat, Pierre, Bani-Sadr, Firouze, Huleux, Thomas, Poizot-Martin, Isabelle, Pugliese, Pascal, Rey, David, Cabié, André, and Group, Dat'AIDS Study
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HIV infection epidemiology ,HIV-positive persons ,HEPATITIS C ,RETROSPECTIVE studies ,DISEASE incidence ,MIXED infections ,DISEASE prevalence ,DESCRIPTIVE statistics ,MEN who have sex with men ,AIDS ,LONGITUDINAL method - Abstract
Background The arrival of highly effective, well-tolerated, direct-acting antiviral agents (DAA) led to a dramatic decrease in hepatitis C virus (HCV) prevalence. Human immunodeficiency virus (HIV)-HCV–coinfected patients are deemed a priority population for HCV elimination, while a rise in recently acquired HCV infections in men who have sex with men (MSM) has been described. We describe the variations in HIV-HCV epidemiology in the French Dat'AIDS cohort. Methods This was a retrospective analysis of a prospective cohort of persons living with HIV (PLWH) from 2012 to 2018. We determined HCV prevalence, HCV incidence, proportion of viremic patients, treatment uptake, and mortality rate in the full cohort and by HIV risk factors. Results From 2012 to 2018, 50 861 PLWH with a known HCV status were followed up. During the period, HCV prevalence decreased from 15.4% to 13.5%. HCV prevalence among new HIV cases increased from 1.9% to 3.5% in MSM but remained stable in other groups. Recently acquired HCV incidence increased from 0.36/100 person-years to 1.25/100 person-years in MSM. The proportion of viremic patients decreased from 67.0% to 8.9%. MSM became the first group of viremic patients in 2018 (37.9%). Recently acquired hepatitis represented 59.2% of viremic MSM in 2018. DAA treatment uptake increased from 11.4% to 61.5%. More treatments were initiated in MSM in 2018 (41.2%) than in intravenous drug users (35.6%). In MSM, treatment at the acute phase represented 30.0% of treatments in 2018. Conclusions A major shift in HCV epidemiology was observed in PLWH in France from 2012 to 2018, leading to a unique situation in which the major group of HCV transmission in 2018 was MSM. Clinical Trials Registration. NCT02898987. [ABSTRACT FROM AUTHOR]
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- 2021
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31. Routine drug resistance testing in proviral HIV‐1 DNA: Prevalence of stop codons and hypermutation, and associated factors
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Alidjinou, Enagnon Kazali, primary, Deldalle, Joséphine, additional, Robineau, Olivier, additional, Hallaert, Christophe, additional, Meybeck, Agnès, additional, Huleux, Thomas, additional, Ajana, Faiza, additional, Hober, Didier, additional, and Bocket, Laurence, additional
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- 2019
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32. Additional file 2: Figure S1. of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, FrĂŠsard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, AndrĂŠ CabiĂŠ, and Cotte, Laurent
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body regions ,nervous system ,fungi ,virus diseases ,digestive system diseases - Abstract
Schematic diagram of HCV transmission compartmental model considering potential HCV treatment during acute phase. (PDF 26 kb)
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- 2017
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33. Additional file 4: Figure S3. of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, Frésard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, Cabié, André, and Cotte, Laurent
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virus diseases - Abstract
Projected prevalence of HIV-HCV coinfection over the next 10 years within each risk group assuming an annual treatment coverage of 30%. (PDF 1673 kb)
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- 2017
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34. Additional file 8: Figure S7. of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, Frésard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, Cabié, André, and Cotte, Laurent
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virus diseases ,digestive system diseases - Abstract
Projected prevalence of HIV-HCV coinfections over the next 10 years in IVDU considering a potential risk of HCV transmission between HIV-negative and HIV-positive individuals. (PDF 153 kb)
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- 2017
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35. Additional file 5: Figure S4. of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, Frésard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, Cabié, André, and Cotte, Laurent
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body regions ,nervous system ,fungi ,virus diseases - Abstract
Projected prevalence (rate) of HIV-HCV coinfections over the next 10 years within each risk groups. (PDF 528 kb)
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- 2017
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36. Additional file 6: Figure S5. of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, FrĂŠsard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, AndrĂŠ CabiĂŠ, and Cotte, Laurent
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virus diseases ,digestive system diseases - Abstract
Projected prevalence of HIV-HCV coinfections over the next 10Â years considering potential HCV treatment during acute phase among high risk MSM. (PDF 187 kb)
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- 2017
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37. Additional file 3: Figure S2. of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, FrĂŠsard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, AndrĂŠ CabiĂŠ, and Cotte, Laurent
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Goodness of fit of the compartmental model to prevalence data between 2012 and 2016 in each risk group (heterosexuals, IVDU, MSM and others). (PDF 34 kb)
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- 2017
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38. Additional file 1: of Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Marc-Antoine Valantin, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Firouze Bani-Sadr, Rey, David, Frésard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, Cabié, André, and Cotte, Laurent
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virus diseases - Abstract
Appendix. Table S1. Extrapolated numbers of HIV-monoinfected patients by subgroups in France in the population under care on January 1, 2016. Table S2. Extrapolated numbers of HIV-HCV coinfected patients with detectable HCV-RNA by subgroups in France in the population under care on January 1, 2016. Table S3. Extrapolated numbers of HIV-infected patients successfully treated for HCV or after spontaneous HCV clearance by subgroups in France in the population under care on January 1, 2016. Table S4. Estimated numbers of HIV-HCV coinfected patients by subgroup in France in the HIV undiagnosed population. Table S5. Number of first HCV infection observed each year in the Dat’AIDs cohort and extended to the diagnosed HIV population in France by risk group. Table S6. Estimated numbers of HIV-HCV coinfected IVDU considering several proportions of external cases, observed reinfection rate in the Dat'AIDs cohort, and an annual treatment coverage of 30% over the next 10 years. Table S7. Estimated numbers of HIV-HCV coinfected IVDU considering several proportions of external cases, reinfection rate based on mean first infection rate observed in the Dat'AIDs cohort, and an annual treatment coverage of 30% over the next 10 years. (DOCX 44 kb)
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- 2017
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39. Clinical and virological features of acute hepatitis A during an ongoing outbreak among men who have sex with men in the North of France
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Boucher, Anne, primary, Meybeck, Agnes, additional, Alidjinou, Kazali, additional, Huleux, Thomas, additional, Viget, Nathalie, additional, Baclet, Veronique, additional, Valette, Michel, additional, Alcaraz, Isabelle, additional, Sauser, Eveline, additional, Bocket, Laurence, additional, and Faiza, Ajana, additional
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- 2018
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40. Incidence of new hepatitis C virus infection is still increasing in French MSM living with HIV
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Pradat, Pierre, primary, Huleux, Thomas, additional, Raffi, François, additional, Delobel, Pierre, additional, Valantin, Marc-Antoine, additional, Poizot-Martin, Isabelle, additional, Pugliese, Pascal, additional, Reynes, Jacques, additional, Rey, David, additional, Hoen, Bruno, additional, Cabie, André, additional, Bani-Sadr, Firouzé, additional, Cheret, Antoine, additional, Duvivier, Claudine, additional, Jacomet, Christine, additional, Fresard, Anne, additional, Hustache-Mathieu, Laurent, additional, and Cotte, Laurent, additional
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- 2018
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41. Antiretroviral therapy as a risk factor for chronic kidney disease: Results from traditional regression modeling and causal approach in a large observational study
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Cuzin, Lise, Pugliese, Pascal, Allavena, Clotilde, Rey, David, Chirouze, Catherine, Bani-Sadr, Firouze, Cabié, André, Huleux, Thomas, Poizot-Martin, Isabelle, Cotte, Laurent, Isnard Bagnis, Corinne, Flandre, Philippe, De Socio, Giuseppe Vittorio, Service de Maladies Infectieuses et Tropicales, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service de maladies infectieuses et tropicales [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'Ingénierie Circulation Transport (LICIT), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-École Nationale des Travaux Publics de l'État (ENTPE)-Université de Lyon, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Reims (CHU Reims), Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique], CHU de la Martinique [Fort de France]-Hôpital Pierre Zobda-Quitman [CHU de la Martinique], CHU de la Martinique [Fort de France]-Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service Universitaire des Maladies Infectieuses et du Voyageur [Tourcoing], Centre Hospitalier Tourcoing, Service d'immuno-hématologie clinique (CISIH), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Equipe 16, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Maladies infectieuses et tropicales [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Chrono-environnement (UMR 6249) (LCE), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
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RNA viruses ,Male ,Oncology ,[SDV]Life Sciences [q-bio] ,lcsh:Medicine ,HIV Infections ,Pathology and Laboratory Medicine ,Biochemistry ,01 natural sciences ,010104 statistics & probability ,Endocrinology ,0302 clinical medicine ,Immunodeficiency Viruses ,Chronic Kidney Disease ,Medicine and Health Sciences ,Public and Occupational Health ,030212 general & internal medicine ,lcsh:Science ,Prospective cohort study ,ComputingMilieux_MISCELLANEOUS ,Multidisciplinary ,Reverse-transcriptase inhibitor ,Antimicrobials ,Drugs ,Antiretrovirals ,Viral Load ,Middle Aged ,Antivirals ,Vaccination and Immunization ,3. Good health ,Nephrology ,Medical Microbiology ,Viral Pathogens ,Creatinine ,Viruses ,Regression Analysis ,Reverse Transcriptase Inhibitors ,Female ,France ,Pathogens ,Research Article ,medicine.drug ,Adult ,medicine.medical_specialty ,Endocrine Disorders ,Anti-HIV Agents ,Immunology ,Antiretroviral Therapy ,Renal function ,Microbiology ,03 medical and health sciences ,Antiviral Therapy ,Virology ,Microbial Control ,Internal medicine ,Retroviruses ,Diabetes Mellitus ,medicine ,Humans ,0101 mathematics ,Risk factor ,Microbial Pathogens ,Pharmacology ,business.industry ,Proportional hazards model ,lcsh:R ,Lentivirus ,Organisms ,Biology and Life Sciences ,HIV ,Models, Theoretical ,medicine.disease ,Regimen ,Metabolic Disorders ,HIV-1 ,Kidney Failure, Chronic ,lcsh:Q ,Ritonavir ,Preventive Medicine ,business ,Viral Transmission and Infection ,Biomarkers ,Kidney disease - Abstract
Objective We investigated whether patients receiving selected antiretroviral combinations had a higher risk of chronic kidney disease (CKD) using traditional regression modeling and a causal approach in a large prospective cohort. Patients and methods For the purpose of this study, we selected 6301 patients who (i) started their first antiretroviral regimen after 1st January 2004, (ii) had at least one serum creatinine measurement within 6 months before ART initiation (study entry), and (iii) had at least two measurements after study entry. Baseline eGFR was defined from the last serum creatinine measurement before study entry. All eGFR values were calculated using the Modification of Diet and Renal Disease (MDRD) equation. Both traditional Cox proportional hazards model and Cox marginal structural models were applied. Distinct coding for antiretroviral therapy exposure were investigated as well as double robust estimators. Results Overall we showed that patients receiving tenofovir (TDF) with a ritonavir boosted protease inhibitor (rbPI) exhibited a higher risk of CKD compared with patients who received TDF with a non-nucleosidic reverse transcriptase inhibitor (NNRTI). Such an increased risk was observed considering both initial and current regimens. Our analysis revealed a clinician-driven switch away from TDF among persons experiencing a decline in renal function while receiving this drug. Conclusion Our results show that combination of TDF and boosted protease inhibitor is associated with a higher CKD risk than TDF and a NNRTI.
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- 2017
42. Direct-acting antiviral treatment against hepatitis C virus infection in HIV-Infected patients – “En route for eradication”?
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Pradat, Pierre, primary, Pugliese, Pascal, additional, Poizot-Martin, Isabelle, additional, Valantin, Marc-Antoine, additional, Cuzin, Lise, additional, Reynes, Jacques, additional, Billaud, Eric, additional, Huleux, Thomas, additional, Bani-Sadr, Firouze, additional, Rey, David, additional, Frésard, Anne, additional, Jacomet, Christine, additional, Duvivier, Claudine, additional, Cheret, Antoine, additional, Hustache-Mathieu, Laurent, additional, Hoen, Bruno, additional, Cabié, André, additional, Cotte, Laurent, additional, Cotte, L., additional, Chidiac, C., additional, Ferry, T., additional, Ader, F., additional, Biron, F., additional, Boibieux, A., additional, Miailhes, P., additional, Perpoint, T., additional, Schlienger, I., additional, Lippmann, J., additional, Braun, E., additional, Koffi, J., additional, Longuet, C., additional, Guéripel, V., additional, Augustin-Normand, C., additional, Brochier, C., additional, Degroodt, S., additional, Pugliese, P., additional, Ceppi, C., additional, Cua, E., additional, Cottalorda, J., additional, Courjon, J., additional, Dellamonica, P., additional, Demonchy, E., additional, De Monte, A., additional, Durant, J., additional, Etienne, C., additional, Ferrando, S., additional, Fuzibet, J.G., additional, Garraffo, R., additional, Joulie, A., additional, Risso, K., additional, Mondain, V., additional, Naqvi, A., additional, Oran, N., additional, Perbost, I., additional, Pillet, S., additional, Prouvost-Keller, B., additional, Wehrlen-Pugliese, S., additional, Rosenthal, E., additional, Sausse, S., additional, Rio, V., additional, Roger, P.M., additional, Brégigeon, S., additional, Faucher, O., additional, Obry-Roguet, V., additional, Orticoni, M., additional, Soavi, M.J., additional, Geneau de Lamarlière, P., additional, Laroche, H., additional, Ressiot, E., additional, Carta, M., additional, Ducassou, M.J., additional, Jacquet, I., additional, Gallie, S., additional, Galinier, A., additional, Ritleng, A.S., additional, Ivanova, A., additional, Blanco-Betancourt, C., additional, Lions, C., additional, Debreux, C., additional, Poizot-Martin, I., additional, Agher, R., additional, Katlama, C., additional, Valantin, M.A., additional, Duvivier, C., additional, Lortholary, O., additional, Lanternier, F., additional, Charlier, C., additional, Rouzaud, C., additional, Aguilar, C., additional, Henry, B., additional, Lebeaux, D., additional, Cessot, G., additional, Gergely, A., additional, Consigny, P.H., additional, Touam, F., additional, Louisin, C., additional, Alvarez, M., additional, Biezunski, N., additional, Cuzin, L., additional, Debard, A., additional, Delobel, P., additional, Delpierre, C., additional, Fourcade, C., additional, Marchou, B., additional, Martin-Blondel, G., additional, Porte, M., additional, Mularczyk, M., additional, Garipuy, D., additional, Saune, K., additional, Lepain, I., additional, Marcel, M., additional, Puntis, E., additional, Atoui, N., additional, Casanova, M.L., additional, Faucherre, V., additional, Jacquet, J.M., additional, Le Moing, V., additional, Makinson, A., additional, Merle De Boever, C., additional, Montoya-Ferrer, A., additional, Psomas, C., additional, Reynes, J., additional, Raffi, F., additional, Allavena, C., additional, Billaud, E., additional, Biron, C., additional, Bonnet, B., additional, Bouchez, S., additional, Boutoille, D., additional, Brunet, C., additional, Jovelin, T., additional, Hall, N., additional, Bernaud, C., additional, Morineau, P., additional, Reliquet, V., additional, Aubry, O., additional, Point, P., additional, Besnier, M., additional, Larmet, L., additional, Hüe, H., additional, Pineau, S., additional, André-Garnier, E., additional, Rodallec, A., additional, Choisy, Ph., additional, Vandame, S., additional, Huleux, Th., additional, Ajana, F., additional, Alcaraz, I., additional, Baclet, V., additional, Huleux, T.H., additional, Melliez, H., additional, Viget, N., additional, Valette, M., additional, Aissi, E., additional, Allienne, Ch., additional, Meybeck, A., additional, Riff, B., additional, Bani-Sadr, F., additional, Rouger, C., additional, Berger, J.L., additional, N'Guyen, Y., additional, Lambert, D., additional, Kmiec, I., additional, Hentzien, M., additional, Lebrun, D., additional, Migault, C., additional, Rey, D., additional, Batard, M.L., additional, Bernard-Henry, C., additional, Cheneau, C., additional, de Mautort, E., additional, Fischer, P., additional, Partisani, M., additional, Priester, M., additional, Lucht, F., additional, Frésard, A., additional, Botelho-Nevers, E., additional, Gagneux-Brunon, A., additional, Cazorla, C., additional, Guglielminotti, C., additional, Daoud, F., additional, Lutz, M.F., additional, Jacomet, C., additional, Laurichesse, H., additional, Lesens, O., additional, Vidal, M., additional, Mrozek, N., additional, Corbin, V., additional, Aumeran, C., additional, Baud, O., additional, Casanova, S., additional, Coban, D., additional, Hustache-Mathieu, L., additional, Thiebaut-Drobacheff, M.C., additional, Foltzer, A., additional, Gendrin, V., additional, Bozon, F., additional, Chirouze, C., additional, Abel, S., additional, Cabié, A., additional, Césaire, R., additional, Santos, G. Dos, additional, Fagour, L., additional, Najioullah, F., additional, Ouka, M., additional, Pierre-François, S., additional, Pircher, M., additional, Rozé, B., additional, Hoen, B., additional, Ouissa, R., additional, and Lamaury, I., additional
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- 2017
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43. Higher rates of HBsAg clearance with tenofovir-containing therapy in HBV/HIV co-infection.
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Gantner, Pierre, Cotte, Laurent, Allavena, Clotilde, Bani-Sadr, Firouzé, Huleux, Thomas, Duvivier, Claudine, Valantin, Marc-Antoine, Jacomet, Christine, Joly, Véronique, Chéret, Antoine, Pugliese, Pascal, Delobel, Pierre, Cabié, André, Rey, David, and null, null
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HEPATITIS B ,HEPATITIS associated antigen ,BAYESIAN analysis ,MIXED infections ,CELL surface antigens ,HIV infections - Abstract
Introduction: Achieving functional cure of chronic HBV infection (Hepatitis B surface antigen [HBsAg] clearance, eventually followed by acquisition of anti-hepatitis B surface antigen [Anti-HBs]) in individuals with HIV and HBV infections is a rare event. In this setting, factors related to HBV cure have not yet been fully characterized. Methods: HIV-infected individuals with chronic HBV infection enrolled in the French Dat’AIDS cohort (NCT02898987), who started combined antiretroviral (cART)-anti-HBV treatment were retrospectively analyzed for HBsAg loss and Anti-HBs seroconversion. Results: Overall, 1419 naïve-subjects received three different cART-anti-HBV treatment schedule: (1) 3TC or FTC only (n = 150), (2) TDF with or without 3TC or FTC (n = 489) and (3) 3TC or FTC as first line followed by adding/switching to TDF as second line (n = 780). Individuals were followed-up for a median of 89 months (IQR, 56–118). HBV-DNA was < 15 IU/mL in 91% of individuals at the end of the follow-up. Overall, 97 individuals cleared HBsAg (0.7/100 patient-years), of whom, 67 seroconverted for Anti-HBs (0.5/100 patient-years). A high CD4 nadir, a short delay between HBV diagnosis and treatment, a longer time on HBV therapy, an African origin and TDF-based therapy were independent predictors of HBsAg clearance (Probability of odds ratio [OR]>1, >95%) suggested by Bayesian analysis. Also, TDF-based regimen as first line (OR, 3.03) or second line (OR, 2.95) increased rates of HBsAg clearance compared to 3TC or FTC alone, with a 99% probability. Conclusions: HBsAg clearance rate was low in HIV-HBV co-infected cART-anti-HBV treated individuals, but was slightly improved on TDF-based regimen. [ABSTRACT FROM AUTHOR]
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- 2019
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44. Antiretroviral exposure and comorbidities in an aging HIV-infected population: The challenge of geriatric patients.
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Allavena, Clotilde, Hanf, Matthieu, Rey, David, Duvivier, Claudine, BaniSadr, Firouze, Poizot-Martin, Isabelle, Jacomet, Christine, Pugliese, Pascal, Delobel, Pierre, Katlama, Christine, Joly, Véronique, Chidiac, Christian, Dournon, Nathalie, Merrien, Dominique, May, Thierry, Reynes, Jacques, Gagneux-Brunon, Amandine, Chirouze, Catherine, Huleux, Thomas, and Cabié, André
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ANTIRETROVIRAL agents ,COMORBIDITY ,HIV infections ,AIDS ,THYMIDINE - Abstract
As HIV-infected adults on successful antiretroviral therapy (ART) are expected to have close to normal lifespans, they will increasingly develop age-related comorbidities. The objective of this cross-sectional study was to compare in the French Dat’AIDS cohort, the HIV geriatric population, aged 75 years and over, to the elderly one, aged from 50 to 74 years. As of Dec 2015, 16,436 subjects (43.8% of the French Dat’AIDS cohort) were aged from 50 to 74 (elderly group) and 572 subjects (1.5%) were aged 75 and over (geriatric group). Durations of HIV infection and of ART were slightly but significantly different, median at 19 and 18 years, and 15 and 16 years in the elderly and geriatric group, respectively. The geriatric group was more frequently at CDC stage C and had a lower nadir CD4. This group had been more exposed to first generation protease inhibitors and thymidine analogues. Despite similar virologic suppression, type of ART at the last visit significantly differed between the 2 groups: triple ART in 74% versus 68.2%, ART ≥ 4 drugs in 4.7% versus 2.7%; dual therapy in 11.6% versus 16.4% in the elderly group and the geriatric group, respectively. In the geriatric group all co-morbidities were significantly more frequent, except dyslipidemia, 4.3% of the elderly group had ≥4 co-morbidities versus18.4% in the geriatric group. Despite more co-morbidities and more advanced HIV infection the geriatric population achieve similar high rate of virologic suppression than the elderly population. A multidisciplinary approach should be developed to face the incoming challenge of aging HIV population. [ABSTRACT FROM AUTHOR]
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- 2018
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45. Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination.
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Virlogeux, Victor, Zoulim, Fabien, Pugliese, Pascal, Poizot-Martin, Isabelle, Valantin, Marc-Antoine, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Bani-Sadr, Firouze, Rey, David, Frésard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, Cabié, André, Cotte, Laurent, and Dat’AIDS Study Group
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HIV infections ,HEPATITIS C virus ,MIXED infections ,EPIDEMIOLOGY ,ANTIVIRAL agents - Abstract
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat'AIDS cohort. Eight risk groups were considered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals, intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence data observed in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosed patients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatment coverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalence among HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCV prevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalence in HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70% would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients would account for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most risk groups, including LR MSM. Elimination in HR MSM will require increased TC. [ABSTRACT FROM AUTHOR]- Published
- 2017
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46. Clinical and virological features of acute hepatitis A during an ongoing outbreak among men who have sex with men in the North of France.
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Boucher, Anne, Meybeck, Agnes, Alidjinou, Kazali, Huleux, Thomas, Viget, Nathalie, Baclet, Veronique, Valette, Michel, Alcaraz, Isabelle, Sauser, Eveline, Bocket, Laurence, and Faiza, Ajana
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SYPHILIS epidemiology ,EPIDEMIOLOGY of sexually transmitted diseases ,CHLAMYDIA infections ,DISEASE outbreaks ,GONORRHEA ,HEPATITIS A ,HEPATITIS viruses ,RNA ,RETROSPECTIVE studies ,SEVERITY of illness index ,ACUTE diseases ,GENOTYPES ,MIXED infections - Abstract
Objectives: Since February 2017, an increase of acute hepatitis A (AHA) cases has been notified in North of France. We aimed to report clinical and virological features of 49 cases treated in three hospitals in Lille European Metropolis (LEM).Methods: All adult patients treated for AHA in 3 LEM hospitals between 20 February and 5 July 2017 were included. Demographic characteristics, exposure risk factors to hepatitis A virus (HAV), AHA manifestations and concomitant sexually transmitted infections (STI) were retrospectively recorded.Results: Forty-nine cases of AHA were diagnosed among which 34 (69%) were hospitalised. Severe AHA occurred in 7 (14%) patients. The median age of cases was 36 years. All cases except 1 were men and 32 (65%) were identified as men having sex with men (MSM). Eleven (23%) patients were HIV-infected, 5 were under HIV pre-exposure prophylaxis (PrEP), 6 had a history of HIV postexposure prophylaxis and 19 had a history of at least one STI. Only three patients had received HAV vaccine. Proportion of patients tested for syphilis, chlamydial and gonococcal infections was 75% (18/24) in those seen by sexual health specialists and 21% (6/29) in those seen by other specialists. At least one concomitant STI was diagnosed in 13 out of 24 tested patients (54%). RT-PCR sequencing was available for 38 cases and confirmed co-circulation of 3 different strains of subgenotype IA (VRD 521 2016: n=24, RIVM-HAV16-090: n=13, V16-25801: n=1), already identified in several European countries.Conclusions: We are facing an outbreak of AHA among MSM in the North of France with a high rate of hospitalisation. Analysis of cases highlighted missed opportunities of vaccination and lack of concomitant STI screening. Awareness among healthcare providers and MSM should be increased and HAV vaccination promoted. [ABSTRACT FROM AUTHOR]- Published
- 2019
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47. Incidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France.
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Rojas Rojas T, Poizot-Martin I, Rey D, Duvivier C, Bani-Sadr F, Cabie A, Delobel P, Jacomet C, Allavena C, Ferry T, Pugliese P, Valantin MA, Lamaury I, Hustache-Matthieu L, Fresard A, Houyou T, Huleux T, Cheret A, Makinson A, Obry-Roguet V, Lions C, Carrieri MP, and Protopopescu C
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- Female, Humans, Incidence, Male, Retrospective Studies, Risk Factors, Breast Neoplasms complications, Breast Neoplasms epidemiology, Coinfection epidemiology, Colorectal Neoplasms complications, Colorectal Neoplasms epidemiology, HIV Infections complications, HIV Infections drug therapy, HIV Infections epidemiology, Hepatitis C complications, Hepatitis C epidemiology, Uterine Cervical Neoplasms complications, Uterine Cervical Neoplasms epidemiology
- Abstract
Background: We aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program., Setting: This is a retrospective study based on the longitudinal data of the French Dat'AIDS cohort., Methods: Standardized incidence ratios (SIR) for ICC and BC, and incidence rates for all three cancers were calculated overall and for specific sub-populations according to nadir CD4 cell count, HIV transmission category, HIV diagnosis period, and HCV coinfection., Results: The 2010-2015 CRC incidence rate was 25.0 [95% confidence interval (CI): 18.6-33.4] per 100,000 person-years, in 44,642 PLWH (both men and women). Compared with the general population, the ICC incidence rate was significantly higher in HIV-infected women both overall (SIR = 1.93, 95% CI: 1.18-3.14) and in the following sub-populations: nadir CD4 ≤ 200 cells/mm3 (SIR = 2.62, 95% CI: 1.45-4.74), HIV transmission through intravenous drug use (SIR = 5.14, 95% CI: 1.93-13.70), HCV coinfection (SIR = 3.52, 95% CI: 1.47-8.47) and HIV diagnosis before 2000 (SIR = 2.06, 95% CI: 1.07-3.97). Conversely, the BC incidence rate was significantly lower in the study sample than in the general population (SIR = 0.56, 95% CI: 0.42-0.73)., Conclusion: The present study showed no significant linear trend between 2010 and 2015 in the incidence rates of the three cancers explored in the PLWH study sample. Specific recommendations for ICC screening are still required for HIV-infected women and should focus on sub-populations at greatest risk., Competing Interests: The authors have declared that no competing interests exist.
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- 2022
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48. No barrier to care, yet disparities in the HIV care continuum in France: a nationwide population study.
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Cuzin L, Allavena C, Cotte L, Delpierre C, Huleux T, Palich R, Delobel P, Raffi F, and Cabié A
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- Continuity of Patient Care, Female, France epidemiology, Homosexuality, Male, Humans, Male, Prospective Studies, HIV Infections drug therapy, HIV Infections epidemiology, Sexual and Gender Minorities
- Abstract
Objectives: Even in an 'optimal' health system, patients' characteristics may have an impact on their care. We investigated whether age, gender and place of birth have an impact in the HIV care continuum in France, a country with a universal free healthcare system., Methods: We estimated differences in the 5 year restricted mean percentage of person-time spent (i) in care, (ii) receiving ART and (iii) on ART and virally suppressed among 2432 (30.2%) women, 3925 MSM (48.7%) and 1709 men who have sex with women (MSW; 21.2%) entering care in the Dat'AIDS French prospective cohort between 1 January 2013 and 31 December 2017. Trial registration: Clinicaltrials.gov reference NCT02898987., Results: Men and women spent 85.6% and 82.8% of person-time on ART and 69.9% and 65% suppressed, respectively. MSM, MSW and women spent 86.9%, 82.6% and 82.8% of person-time on ART and 72.5%, 63.7% and 65% suppressed, respectively. Patients born in France (47%) and patients born abroad spent 87.9% and 81.9% of person-time on ART and 74.6% and 62.9% suppressed, respectively. Young men born abroad were found to spend the smallest person-time with non-detectable viral load (53% for MSW and 58.1% for MSM)., Conclusions: Despite free access to care and universal ART in France, disparities remain in the HIV continuum care across age, country of birth and way of HIV acquisition. Clinical and public health interventions targeting specific patients' conditions are needed., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2021
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49. Initiation of Antiretroviral Therapy Containing Integrase Inhibitors Increases the Risk of IRIS Requiring Hospitalization.
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Dutertre M, Cuzin L, Demonchy E, Puglièse P, Joly V, Valantin MA, Cotte L, Huleux T, Delobel P, and Martin-Blondel G
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- Adult, CD4 Lymphocyte Count, Female, France, HIV Infections immunology, HIV Integrase Inhibitors administration & dosage, Hospitalization, Humans, Immune Reconstitution Inflammatory Syndrome immunology, Immunocompromised Host, Incidence, Male, Middle Aged, Patient Selection, Prospective Studies, Risk Assessment, Risk Factors, AIDS-Related Opportunistic Infections drug therapy, Antiretroviral Therapy, Highly Active, HIV Infections drug therapy, HIV Integrase Inhibitors adverse effects, Immune Reconstitution Inflammatory Syndrome chemically induced
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- 2017
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