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514 results on '"Hummel, Friedhelm"'

6. Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

Author

Wessel, Maximilian J., Beanato, Elena, Popa, Traian, Windel, Fabienne, Vassiliadis, Pierre, Menoud, Pauline, Beliaeva, Valeriia, Violante, Ines R., Abderrahmane, Hedjoudje, Dzialecka, Patrycja, Park, Chang-Hyun, Maceira-Elvira, Pablo, Morishita, Takuya, Cassara, Antonino M., Steiner, Melanie, Grossman, Nir, Neufeld, Esra, and Hummel, Friedhelm C.

Published
2023
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7. Stroke Recovery–Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition

Author

Harquel, Sylvain, Cadic-Melchior, Andéol, Morishita, Takuya, Fleury, Lisa, Witon, Adrien, Ceroni, Martino, Brügger, Julia, Meyer, Nathalie H., Evangelista, Giorgia G., Egger, Philip, Beanato, Elena, Menoud, Pauline, Van de Ville, Dimitri, Micera, Silvestro, Blanke, Olaf, Léger, Bertrand, Adolphsen, Jan, Jagella, Caroline, Constantin, Christophe, Alvarez, Vincent, Vuadens, Philippes, Turlan, Jean-Luc, Mühl, Andreas, Bonvin, Christophe, Koch, Philipp J., Wessel, Maximilian J., and Hummel, Friedhelm C.

Published
2024
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9. Efficacy and safety of transcranial direct current stimulation to the ipsilesional motor cortex in subacute stroke (NETS): a multicenter, randomized, double-blind, placebo-controlled trial

Author

Cordes, Diana, Gerloff, Christian, Heise, Kirstin-Friederike, Hummel, Friedhelm C., Schulz, Robert, Wolf, Silke, Haevernick, Kerstin, Krüger, Heike, Krause, Linda, Suling, Anna, Wegscheider, Karl, Zapf, Antonia, Dressnandt, Jürgen, Schäpers, Barbara, Schrödl, Christoph, Hauptmann, Björn, Kirchner, Anja, Brault, Anna, Gutschalk, Alexander, Richter, Constanze, Nowak, Dennis A., Veldema, Jitka, Koch, Giacomo, Maiella, Michele, Dohle, Christian, Jettkowski, Katrin, Pilz, Mario, Hamzei, Farsin, Olischer, Lydia, Renner, Caroline, Groß, Marcus, Jöbges, Michael, and Voller, Bernhard

Published
2024
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11. New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.

Author

Boltze, Johannes, Aronowski, Jaroslaw A, Badaut, Jerome, Buckwalter, Marion S, Caleo, Mateo, Chopp, Michael, Dave, Kunjan R, Didwischus, Nadine, Dijkhuizen, Rick M, Doeppner, Thorsten R, Dreier, Jens P, Fouad, Karim, Gelderblom, Mathias, Gertz, Karen, Golubczyk, Dominika, Gregson, Barbara A, Hamel, Edith, Hanley, Daniel F, Härtig, Wolfgang, Hummel, Friedhelm C, Ikhsan, Maulana, Janowski, Miroslaw, Jolkkonen, Jukka, Karuppagounder, Saravanan S, Keep, Richard F, Koerte, Inga K, Kokaia, Zaal, Li, Peiying, Liu, Fudong, Lizasoain, Ignacio, Ludewig, Peter, Metz, Gerlinde AS, Montagne, Axel, Obenaus, Andre, Palumbo, Alex, Pearl, Monica, Perez-Pinzon, Miguel, Planas, Anna M, Plesnila, Nikolaus, Raval, Ami P, Rueger, Maria A, Sansing, Lauren H, Sohrabji, Farida, Stagg, Charlotte J, Stetler, R Anne, Stowe, Ann M, Sun, Dandan, Taguchi, Akihiko, Tanter, Mickael, Vay, Sabine U, Vemuganti, Raghu, Vivien, Denis, Walczak, Piotr, Wang, Jian, Xiong, Ye, and Zille, Marietta

Subjects
cell therapies, dementia, experimental therapy, hemorrhage, neuroprotection, neurorehabilitation, stroke, translational research, Biochemistry and Cell Biology, Neurosciences, Cognitive Sciences
Abstract

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.

Published
2021

13. Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial protocol

Author

Dechantsreiter, Esther, Padberg, Frank, Morash, Alon, Kumpf, Ulrike, Nguyen, Arthur, Menestrina, Zeno, Windel, Fabienne, Burkhardt, Gerrit, Goerigk, Stephan, Morishita, Takuya, Soldini, Aldo, Ahissar, Shira, Cohen, Tamar, Pasqualotto, Angela, Rubene, Linda, Konosonoka, Liene, Keeser, Daniel, Zill, Peter, Assi, Razan, Gardier, Rémy, Viñals, Roser, Thiran, Jean-Philippe, Segman, Ronen, Benjamini, Yuval, Bonne, Omer, Hummel, Friedhelm Christoph, Bavelier, Daphne, Rancans, Elmars, and Nahum, Mor

Published
2023
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19. Evaluating reproducibility and subject-specificity of microstructure-informed connectivity

Author

Koch, Philipp J., Girard, Gabriel, Brügger, Julia, Cadic-Melchior, Andéol G., Beanato, Elena, Park, Chang-Hyun, Morishita, Takuya, Wessel, Maximilian J., Pizzolato, Marco, Canales-Rodríguez, Erick J., Fischi-Gomez, Elda, Schiavi, Simona, Daducci, Alessandro, Piredda, Gian Franco, Hilbert, Tom, Kober, Tobias, Thiran, Jean-Philippe, and Hummel, Friedhelm C.

Published
2022
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22. Differential Impact of Brain Network Efficiency on Poststroke Motor and Attentional Deficits

Author

Evangelista, Giorgia G., Egger, Philip, Brügger, Julia, Beanato, Elena, Koch, Philipp J., Ceroni, Martino, Fleury, Lisa, Cadic-Melchior, Andéol, Meyer, Nathalie H., Rodríguez, Diego de León, Girard, Gabriel, Léger, Bertrand, Turlan, Jean-Luc, Mühl, Andreas, Vuadens, Philippe, Adolphsen, Jan, Jagella, Caroline E., Constantin, Christophe, Alvarez, Vincent, San Millán, Diego, Bonvin, Christophe, Morishita, Takuya, Wessel, Maximilian J., Van De Ville, Dimitri, and Hummel, Friedhelm C.

Published
2023
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28. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)

Author

Lefaucheur, Jean-Pascal, Aleman, André, Baeken, Chris, Benninger, David H., Brunelin, Jérôme, Di Lazzaro, Vincenzo, Filipović, Saša R., Grefkes, Christian, Hasan, Alkomiet, Hummel, Friedhelm C., Jääskeläinen, Satu K., Langguth, Berthold, Leocani, Letizia, Londero, Alain, Nardone, Raffaele, Nguyen, Jean-Paul, Nyffeler, Thomas, Oliveira-Maia, Albino J., Oliviero, Antonio, Padberg, Frank, Palm, Ulrich, Paulus, Walter, Poulet, Emmanuel, Quartarone, Angelo, Rachid, Fady, Rektorová, Irena, Rossi, Simone, Sahlsten, Hanna, Schecklmann, Martin, Szekely, David, and Ziemann, Ulf

Published
2020
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32. Effects of hippocampal noninvasive theta-burst stimulation on consolidation of associative memory in healthy older adults

Author

Popa, Traian, primary, Beanato, Elena, additional, Wessel, Maximilian Jonas, additional, Menoud, Pauline, additional, Windel, Fabienne, additional, Vassiliadis, Pierre, additional, Violante, Ines R., additional, Alania, Katevan, additional, Dzialecka, Patrycja, additional, Grossman, Nir, additional, Neufeld, Esra, additional, and Hummel, Friedhelm C., additional

Published
2023
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34. Effects of tDCS on motor learning and memory formation: A consensus and critical position paper

Author

Buch, Ethan R., Santarnecchi, Emiliano, Antal, Andrea, Born, Jan, Celnik, Pablo A., Classen, Joseph, Gerloff, Christian, Hallett, Mark, Hummel, Friedhelm C., Nitsche, Michael A., Pascual-Leone, Alvaro, Paulus, Walter J., Reis, Janine, Robertson, Edwin M., Rothwell, John C., Sandrini, Marco, Schambra, Heidi M., Wassermann, Eric M., Ziemann, Ulf, and Cohen, Leonardo G.

Published
2017
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39. Novel personalized treatment strategy for patients with chronic stroke with severe upper-extremity impairment: The first patient of the AVANCER trial

Author

Bigoni, Claudia, primary, Beanato, Elena, additional, Harquel, Sylvain, additional, Hervé, Julie, additional, Oflar, Meltem, additional, Crema, Andrea, additional, Espinosa, Arnau, additional, Evangelista, Giorgia G., additional, Koch, Philipp, additional, Bonvin, Christophe, additional, Turlan, Jean-Luc, additional, Guggisberg, Adrian, additional, Morishita, Takuya, additional, Wessel, Maximilian J., additional, Zandvliet, Sarah B., additional, and Hummel, Friedhelm C., additional

Published
2023
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44. Mechanisms underlying reinforcement learning of motor skills

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - Faculté de médecine et médecine dentaire, Hummel, Friedhelm, Derosiere, Gerard, Van de Ville, Dimitri, Blanke, Olaf, Schambra, Heidi, Hardwick, Robert, Duqué, Julie, Vassiliadis, Pierre, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - Faculté de médecine et médecine dentaire, Hummel, Friedhelm, Derosiere, Gerard, Van de Ville, Dimitri, Blanke, Olaf, Schambra, Heidi, Hardwick, Robert, Duqué, Julie, and Vassiliadis, Pierre

Abstract

Motor learning allows animals, including human beings, to acquire skills that are essential for efficient interactions with the environment. This ability to learn new motor skills is of great practical relevance for daily-life activities (such as when learning to drive), but also for motor rehabilitation after a lesion of the nervous system (such as a stroke). For a long time, motor learning has been mainly conceptualized as a process allowing to iteratively correct movements based on sensory information (e.g., visual, somatosensory). Importantly though, in the last years, there has been an increased appreciation that motor learning also results from other mechanisms including reinforcement learning, a process through which appropriate actions are selected through outcome-based feedback (e.g., success or failure). As such, recent evidence shows that reinforcement feedback and mo-tivation can be beneficial for motor learning both in healthy individuals and neurological populations. Despite the potential importance of these findings to improve current rehabil-itation protocols, the mechanisms underlying reinforcement-related improvements in mo-tor learning remain largely unexplored. This PhD aimed at providing deeper mechanistic understanding of reinforcement learning of motor skills through behavioral analyses, neuroimaging and non-invasive brain stimulation. In Study 1, I found that enhancing motivation (by providing monetary reward for good performance) during a motor training can lead to persistent improvements in performance that are not obtained with reinforce-ment feedback only, and are related to an increased regulation of motor variability based on previous outcomes. In Study 2, I investigated the effect of reward timing (i.e., the delay between the end of movement execution and reward receipt) on motor learning and found that delaying reward by only a few seconds could strongly influence motor learning dynamics and consolidation. Finally, in Study 3, I inves, (MED - Sciences médicales) -- UCL, 2023

Published
2023

47. Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network

Author

Bevilacqua Michele, Huxlin Krystel, Hummel, Friedhelm, and Raffin, Estelle

Subjects
History, TMS-EEG, Hebbian plasticity, Polymers and Plastics, Granger Causality, Business and International Management, Industrial and Manufacturing Engineering, Visual motion processing
Abstract

Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single pulse transcranial Magnetic Stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway and direction specificity) and its nature (oscillatory signature and perceptual consequences) when applied along the ascending (Forward) and descending (Backward) motion discrimination pathway. We found unspecific connectivity increases in bottom-up inputs in the low Gamma band, probably reflecting visual task exposure. A clear distinction in information transfer occurred in the re-entrant Alpha signals, which were only modulated by Backward ccPAS, and predictive of visual improvements in healthy participants. These results suggest a causal involvement of the re-entrant MT to V1 low frequency inputs in motion discrimination and integration in healthy participants. Modulating re-entrant input activity could provide single-subject prediction scenarios for visual recovery. Visual recovery might indeed partly rely on these residual inputs projecting to spared V1 neurons.Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single pulse transcranial Magnetic Stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway and direction specificity) and its nature (oscillatory signature and perceptual consequences) when applied along the ascending (Forward) and descending (Backward) motion discrimination pathway. We found unspecific connectivity increases in bottom-up inputs in the low Gamma band, probably reflecting visual task exposure. A clear distinction in information transfer occurred in the re-entrant Alpha signals, which were only modulated by Backward ccPAS, and predictive of visual improvements in healthy participants. These results suggest a causal involvement of the re-entrant MT to V1 low frequency inputs in motion discrimination and integration in healthy participants. Modulating re-entrant input activity could provide single-subject prediction scenarios for visual recovery. Visual recovery might indeed partly rely on these residual inputs projecting to spared V1 neurons.

Published
2023
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49. Novel personalized treatment strategy for patients with chronic stroke with severe upper-extremity impairment: The first patient of the AVANCER trial

Author

Bigoni, Claudia, Beanato, Elena, Harquel, Sylvain, Hervé, Julie, Oflar, Meltem, Crema, Andrea, Espinosa, Arnau, Evangelista, Giorgia G, Koch, Philipp, Bonvin, Christophe, Turlan, Jean-Luc, Guggisberg, Adrian, Morishita, Takuya, Wessel, Maximilian J, Zandvliet, Sarah B, and Hummel, Friedhelm C

Subjects
610 Medicine & health
Abstract

BACKGROUND Around 25% of patients who have had a stroke suffer from severe upper-limb impairment and lack effective rehabilitation strategies. The AVANCER proof-of-concept clinical trial (NCT04448483) tackles this issue through an intensive and personalized-dosage cumulative intervention that combines multiple non-invasive neurotechnologies. METHODS The therapy consists of two sequential interventions, lasting until the patient shows no further motor improvement, for a minimum of 11 sessions each. The first phase involves a brain-computer interface governing an exoskeleton and multi-channel functional electrical stimulation enabling full upper-limb movements. The second phase adds anodal transcranial direct current stimulation of the motor cortex of the lesioned hemisphere. Clinical, electrophysiological, and neuroimaging examinations are performed before, between, and after the two interventions (T0, T1, and T2). This case report presents the results from the first patient of the study. FINDINGS The primary outcome (i.e., 4-point improvement in the Fugl-Meyer assessment of the upper extremity) was met in the first patient, with an increase from 6 to 11 points between T0 and T2. This improvement was paralleled by changes in motor-network structure and function. Resting-state and transcranial magnetic stimulation-evoked electroencephalography revealed brain functional changes, and magnetic resonance imaging (MRI) measures detected structural and task-related functional changes. CONCLUSIONS These first results are promising, pointing to feasibility, safety, and potential efficacy of this personalized approach acting synergistically on the nervous and musculoskeletal systems. Integrating multi-modal data may provide valuable insights into underlying mechanisms driving the improvements and providing predictive information regarding treatment response and outcomes. FUNDING This work was funded by the Wyss-Center for Bio and Neuro Engineering (WCP-030), the Defitech Foundation, PHRT-#2017-205, ERA-NET-NEURON (Discover), and SNSF (320030L_197899, NiBS-iCog).

Published
2023
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