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Background: Toxoplasma gondii coinfection can modify host immune responses and the severity and spread of other parasites. We investigated how T. gondii and Trichinella spiralis infections counter-regulate each other's immune responses. Methods: The parasite burden, the expression of T. gondii rhoptry kinase ROP18 and T. spiralis putative serine protease (TsSP), the IgG1 and IgG2a responses, besides histopathological and immunohistochemical staining with iNOS and arginase were used to evaluate the dynamics of coinfection. Results: Through their effects on host immune responsiveness, coinfection with T. gondii modified the virulence of T. spiralis infection. Coinfected animals with high and low doses of T. gondii demonstrated significant reductions in the T. spiralis burden of 75.2% and 68.2%, respectively. TsSP expression was downregulated in both groups by 96.2% and 86.7%, whereasROP18 expression was downregulated by only 6% and10.6%, respectively. In coinfected mice, elevated levels of T. gondii-specific IgG2a antibodies were detected. Th1 induced by T. gondii inhibits the Th2 response to T. spiralis in coinfected animals with high iNOS expression andlow-arginine1 expression. Conclusion: T. gondii infection induces a shift toward a Th1-type immune response while suppressing a helminth-specific Th2 immune response, paving the way for developing novel vaccines and more efficient control strategies. [ABSTRACT FROM AUTHOR]

This paper compares four prototype Synchronous Reluctance Motors (SynRMs) having an identical geometry of iron lamination stacks in the stator and rotor. Two different stator winding layouts are employed: a conventional three-phase star connection and a combined star-delta winding. In addition, two rotors are considered: a conventional rotor without magnets and a rotor with ferrite magnets. The performance of the four SynRMs is evaluated using a two-dimensional (2D) Finite Element Model (FEM). For the same copper volume and current, the combined star-delta-connected stator with Permanent Magnets (PMs) in the rotor corresponds to an approximately 22% increase in the output torque at rated current and speed compared to the conventional machine. This improvement is mainly thanks to adding ferrite PMs in the rotor as well as to the improved winding factor of the combined star-delta winding. The torque gain increases up to 150% for low current. Moreover, the rated efficiency is 93.60% compared to 92.10% for the conventional machine. On the other hand, the impact on the power factor and losses of SynRM when using the star-delta windings instead of the star windings is merely negligible. The theoretical results are experimentally validated using four identical prototype machines with identical lamination stacks but different rotors and winding layouts. [ABSTRACT FROM AUTHOR]

The rotor design of Synchronous Reluctance Motors (SynRMs) has a large effect on their efficiency, torque density and torque ripple. In order to achieve a good compromise between these three goals, an optimized rotor geometry is necessary. A finite element method (FEM) is a good tool for the optimization. However, the computation time is an obstacle as there are many geometrical parameters to be optimized. The flux-barrier widths and angles are the two most crucial parameters for the SynRM output torque and torque ripple. This paper proposes an easy-to-use set of parametrized equations to select appropriate values for these two rotor parameters. With these equations, the reader can design a SynRM of distributed windings with a low torque ripple and with a better average torque. The methodology is valid for a wide range of SynRMs. To check the validity of the proposed equations, the sensitivity analysis for the variation of these two parameters on the SynRM torque and torque ripple is carried out. In addition, the analysis in this paper gives insight into the behavior of the machine as a function of these two parameters. Furthermore, the torque and torque ripple of SynRMs having a rotor with three, four and five flux-barriers are compared with three literature approaches. The comparison shows that the proposed equations are effective in choosing the flux-barrier angles and widths for low torque ripple and better average torque. Experimental results have been obtained to confirm the FEM results and to validate the methodology for choosing the rotor parameters. [ABSTRACT FROM AUTHOR]