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Your search keyword '"Immune response -- Models"' showing total 41 results
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41 results on '"Immune response -- Models"'

1. Modeling human adaptive immune responses with tonsil organoids

Author

Wagar, Lisa E., Salahudeen, Ameen, Constantz, Christian M., Wendel, Ben S., Lyons, Michael M., Mallajosyula, Vamsee, Jatt, Lauren P., Adamska, Julia Z., Blum, Lisa K., Gupta, Neha, Jackson, Katherine J.L., Yang, Fan, Roltgen, Katharina, Roskin, Krishna M., Blaine, Kelly M., Meister, Kara D., Ahmad, Iram N., Cortese, Mario, Dora, Emery G., Tucker, Sean N., Sperling, Anne I., Jain, Aarti, Davies, D. Huw, Felgner, Philip L., Hammer, Gregory B., Kim, Peter S., Robinson, William H., Boyd, Scott D., Kuo, Calvin J., and Davis, Mark M.

Subjects
Human cell culture -- Usage, Immune response -- Models, Tonsils -- Physiological aspects -- Models, Biological sciences, Health
Abstract

Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key germinal center features in vitro, including the production of antigen-specific antibodies, somatic hypermutation and affinity maturation, plasmablast differentiation and class-switch recombination. We use this system to define the essential cellular components necessary to produce an influenza vaccine response. We also show that it can be used to evaluate humoral immune responses to two priming antigens, rabies vaccine and an adenovirus-based severe acute respiratory syndrome coronavirus 2 vaccine, and to assess the effects of different adjuvants. This system should prove useful for studying critical mechanisms underlying adaptive immunity in much greater depth than previously possible and to rapidly test vaccine candidates and adjuvants in an entirely human system. An in vitro human tonsil tissue-based system captures key features of a functional germinal center and can be used to study humoral immune responses to vaccines, new antigens and adjuvants., Author(s): Lisa E. Wagar [sup.1] [sup.15] , Ameen Salahudeen [sup.2] [sup.16] , Christian M. Constantz [sup.3] , Ben S. Wendel [sup.1] , Michael M. Lyons [sup.1] , Vamsee Mallajosyula [sup.3] [...]

Published
2021
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3. Research from Shanxi Normal University Broadens Understanding of HIV/AIDS (Dynamic analysis and optimal control of a fractional order HIV/HTLV co-infection model with HIV-specific antibody immune response)

Subjects
HIV (Viruses) -- Models, Viral antibodies -- Models, Immune response -- Models, Infection -- Models, Antibodies -- Models, Health
Abstract

2024 APR 8 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on HIV/AIDS. According to news originating from Taiyuan, People's Republic of [...]

Published
2024

4. Wayne State University Researchers Illuminate Research in Pituitary Gonadotropins (A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors)

Subjects
Immune response -- Models, Immunotherapy -- Testing, Cancer -- Care and treatment, Genetic regulation -- Analysis, Health
Abstract

2022 DEC 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in pituitary gonadotropins. According to news reporting out [...]

Published
2022

6. Study Findings on Head and Neck Cancer Published by Researchers at Ningbo University (Predicting the prognosis, immune response, and immunotherapy in head and neck squamous cell carcinoma using a novel risk model based on anoikis-related lncRNAs)

Subjects
Oncology, Experimental -- Models, Metastasis -- Prognosis -- Risk factors, Immune response -- Models, Immunotherapy -- Models, Squamous cell carcinoma -- Risk factors -- Prognosis, Risk assessment -- Models, Cancer -- Research, Head and neck cancer -- Prognosis -- Risk factors, Health
Abstract

2023 DEC 20 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Researchers detail new data in head and neck cancer. According to news reporting from Ningbo [...]

Published
2023

7. Study Results from Department of Gynaecology and Obstetrics Provide New Insights into Cervical Cancer (Novel risk prediction models, involving coagulation, thromboelastography, stress response, and immune function indicators, for deep vein ...)

Subjects
Oncology, Experimental -- Models, Immune response -- Models, Cervical cancer -- Risk factors, Cancer -- Research, Ovarian cancer -- Risk factors, Health
Abstract

2023 DEC 11 (NewsRx) -- By a News Reporter-Staff News Editor at OBGYN & Reproduction Week -- Investigators discuss new findings in cervical cancer. According to news reporting originating from [...]

Published
2023

9. Taif University Researchers Provide New Data on HIV/AIDS (Novel codynamics of the HIV-1/HTLV-I model involving humoral immune response and cellular outbreak: A new approach to probability density functions and fractional operators)

Subjects
HIV (Viruses) -- Models, T cells -- Models, Immune response -- Models, Distribution (Probability theory) -- Models, Health
Abstract

2023 NOV 13 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Fresh data on HIV/AIDS are presented in a new report. According to news originating from [...]

Published
2023

10. Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis

Author

Demehri, Shadmehr, Cunningham, Trevor J., Manivasagam, Sindhu, Ngo, Kenneth H., Tuchayi, Sara Moradi, Reddy, Rasika, Meyers, Melissa A., DeNardo, David G., and Yokoyama, Wayne M.

Subjects
Thymic stromal lymphopoietin -- Properties, Immune response -- Models, Breast cancer -- Models, Health care industry
Abstract

Advances in the field of cancer immunology, including studies on tumor-infiltrating [CD8.sup.+] cytotoxic T lymphocytes (CTLs), have led to new immunotherapeutics with proven efficacy against late-stage cancers. However, the antitumor potential of the immune system in targeting early-stage cancers remains uncertain. Here, we demonstrated that both genetic and chemical induction of thymic stromal lymphopoietin (TSLP) at a distant site leads to robust antitumor immunity against spontaneous breast carcinogenesis in mice. Breast tumors exposed to high circulating levels of TSLP were arrested at an early adenoma-like stage and were prevented from advancing to late carcinoma and metastasis. Additionally, [CD4.sup.+] Th2 cells mediated the antitumor effects of TSLP, challenging the notion that Th2 cells only promote cancer. We also discovered that TSLP is expressed by the breast tumor cells themselves and acts to block breast cancer promotion. Moreover, TSLP-induced immunity also blocked early stages of pancreatic cancer development. Together, our findings demonstrate that TSLP potently induces immunity directed against early stages of breast cancer development without causing inflammation in the normal breast tissue. Moreover, our results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers., Introduction Studies of the immune response to late-stage cancers including the role of tumor-infiltrating [CD8.sup.+] cytotoxic T lymphocytes (CTLs) in attacking cancer cells have led to promising new cancer immunotherapeutics [...]

Published
2016
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11. Studies in the Area of Personalized Medicine Reported from University Paris-Saclay (Evaluating immune response in vitro in a relevant microenvironment: a high-throughput microfluidic model for clinical screening)

Subjects
Microfluidics -- Models, Immune response -- Models, Health
Abstract

2023 JAN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on personalized medicine have been published. According to news reporting [...]

Published
2023

12. Oklahoma State University Researchers Provide Details of New Studies and Findings in the Area of Tissue Engineering (3D tissue-engineered lung models to study immune responses following viral infections of the small airways)

Subjects
Medical research -- Models, Medicine, Experimental -- Models, Tissue engineering -- Models, Respiratory tract diseases -- Models, Immune response -- Models, Infection -- Models, Coronaviruses -- Models, Biotechnology industry, Pharmaceuticals and cosmetics industries, Oklahoma State University
Abstract

2022 SEP 28 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Current study results on tissue engineering have been published. According to news reporting originating from [...]

Published
2022

13. Study Data from University of Manchester Provide New Insights into Chemotherapy (A Deterministic and Stochastic Model for the System Dynamics of Tumor-immune Responses To Chemotherapy)

Subjects
Physical fitness -- Models, Immune response -- Models, Tumors -- Research -- Models, Medical research -- Models, Chemotherapy -- Models, Obesity, Cancer research, Cancer patients, Immune system, Editors, Health
Abstract

2019 APR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Drugs and Therapies - Chemotherapy. According to [...]

Published
2019

14. Researchers at Lomonosov Moscow State University Have Reported New Data on Mycobacterium tuberculosis (A new model for chronic and reactivation tuberculosis: Infection with genetically attenuated Mycobacterium tuberculosis in mice with polar ...)

Subjects
Tuberculosis -- Models, Immune response -- Models, Medical research, Health
Abstract

2018 DEC 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Gram-Positive Bacteria - Mycobacterium tuberculosis. According to [...]

Published
2018

15. Research Reports on Immunoglobulins from Institut Teknologi Bandung Provide New Insights (Modeling Dengue Immune Responses Mediated by Antibodies: A Qualitative Study)

Subjects
Dengue -- Models, Immune response -- Models, Viral antibodies -- Models, Infection -- Models, Vaccines -- Models, Antibodies -- Models, Health
Abstract

2021 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Vaccine Weekly -- Investigators publish new report on immunoglobulins. According to news reporting out of Bandung, Indonesia, by [...]

Published
2021

16. Studies from Catholic University of the Sacred Heart Provide New Data on Biology (Microfluidic Co-culture Models for Dissecting the Immune Response In In Vitro Tumor Microenvironments)

Subjects
Tumors -- Physiological aspects -- Models, Microfluidics -- Usage, Immune response -- Models, Biological sciences, Health
Abstract

2021 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Biology have been presented. According to news reporting originating from Milan, [...]

Published
2021

17. New Dimethylamines Study Findings Have Been Reported by Investigators at Aristotle University (Interaction of a Cannabinoid-2 Agonist With Tramadol on Nociceptive Thresholds and Immune Responses in a Rat Model of Incisional Pain)

Subjects
Interleukins -- Models, Physical fitness -- Models, Immune response -- Models, Tramadol -- Research -- Models, Health
Abstract

2016 DEC 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Dimethylamines have been published. According to news originating [...]

Published
2016

18. Study Results from Chinese Academy of Sciences Update Understanding of COVID-19 (Biomimetic Human Disease Model of Sars-cov-2-induced Lung Injury and Immune Responses On Organ Chip System)

Subjects
Lung diseases -- Models, Immune response -- Models, Coronaviruses -- Models, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2021 JAN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Coronavirus - COVID-19 have been published. According to news originating from [...]

Published
2021

19. New Multiple Sclerosis Findings from University of Turin Discussed (Computational modeling of the immune response in multiple sclerosis using epimod framework)

Subjects
Medical research -- Models, Medicine, Experimental -- Models, Multiple sclerosis -- Models, Immune response -- Models, Computer simulation -- Models, Computer-generated environments -- Models, Health
Abstract

2021 JAN 1 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Autoimmune Diseases and Conditions - Multiple Sclerosis. According [...]

Published
2021

20. Secret Tunnels Between Skull, Brain Speed Immune Cells After Stroke in Mice

Subjects
Skull -- Physiological aspects, Immune system -- Physiological aspects -- Health aspects, Immune response -- Models, Stroke -- Models, Health
Abstract

MONDAY, Aug. 27, 2018 (HealthDay News) -- Immune cells use channels that run from skull bone marrow to the lining of the brain to rapidly respond to stroke and other [...]

Published
2018

21. Corbus Pharmaceuticals Announces Publication Demonstrating Lenabasum as First Drug to Stimulate Resolution of Innate Immune Responses in a Clinical Model

Subjects
Cystic fibrosis -- Models, Scleroderma (Disease) -- Models, Immunotherapy -- Models, Immune response -- Models, General interest, News, opinion and commentary
Abstract

NORWOOD: Corbus Pharmaceuticals Holdings, Inc has issued the following news release: Study identifies lenabasum as important upstream trigger of resolution of innate immune responses Data provides mechanistic validation of positive [...]

Published
2018

22. Investigators at Virginia Tech Report Findings in Aspergillosis (Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis)

Subjects
Transcription (Genetics) -- Models, Pulmonary aspergillosis -- Genetic aspects -- Research -- Models, Immune response -- Models, Medical research -- Models, Aspergillosis, Infection, Anopheles, Editors, Biological sciences, Health
Abstract

2019 FEB 12 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Bacterial Infections and Mycoses - Aspergillosis have been published. According [...]

Published
2019

23. Study Findings from A.M. Jarrett et al Provide New Insights into Breast Cancer (Mathematical modelling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer)

Subjects
Cancer research -- Models, Immune response -- Models, Breast cancer -- Research -- Models, Antineoplastic agents -- Research -- Models, Health
Abstract

2018 OCT 12 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Oncology - Breast Cancer have been presented. According to news [...]

Published
2018

25. Corbus Pharmaceuticals Announces Publication Demonstrating Lenabasum as First Drug to Stimulate Resolution of Innate Immune Responses in a Clinical Model

Subjects
Cystic fibrosis -- Models, Scleroderma (Disease) -- Models, Immunotherapy -- Models, Immune response -- Models, Health
Abstract

2018 MAR 2 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Study identifies lenabasum as important upstream trigger of resolution of innate immune responsesData [...]

Published
2018

26. Study Data from X.H. Guo and Colleagues Update Understanding of Tuberculosis (Roles of monocyte chemotactic protein 1 and nuclear factor-kB in immune response to spinal tuberculosis in a New Zealand white rabbit model)

Subjects
Medical research -- Models, Tuberculosis -- Research -- Models, Immune response -- Models, Rabbits -- Models, Biological sciences, Health
Abstract

2017 NOV 28 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Mycobacterium Infections - Tuberculosis. According to news reporting originating [...]

Published
2017

27. Researchers at Texas Christian University Detail Findings in Drug Resistance (Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms)

Subjects
Antiviral agents -- Models, Drug resistance -- Drug therapy -- Models, Influenza -- Drug therapy -- Models, Immune response -- Models, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2017 JUL 26 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drug Resistance have been published. According to news reporting out of [...]

Published
2017

28. New Estradiol Congeners Findings from Brown University School of Medicine Outlined (Estradiol and progesterone influence on influenza infection and immune response in a mouse model)

Subjects
Hormones -- Models, Estradiol -- Research -- Models, Influenza -- Research -- Models, Progesterone -- Research -- Models, Immune response -- Models, Phenols (Class of compounds) -- Models, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2017 JUN 14 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Hormones - Estradiol Congeners have been published. According to news reporting [...]

Published
2017

30. Studies from Nutritional Immunology and Molecular Medicine Laboratory Yield New Information about Helicobacter pylori [Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori ...]

Subjects
Inflammation -- Models, Gastrointestinal diseases -- Models, Ligases -- Models, Immune response -- Models, Helicobacter pylori -- Models, Health
Abstract

2017 JAN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Gram-Negative Bacteria - Helicobacter pylori is the subject of a [...]

Published
2017

31. Investigators from Ewha Woman's University Release New Data on Kidney Transplants (Feedback control of the immune response of renal transplant recipients with inequality constraints)

Subjects
Kidney transplantation -- Models, Equality -- Models, Medical research -- Models, Organ transplant recipients -- Models, Immune response -- Models, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2016 JUL 13 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- New research on Transplant Medicine is the subject of a report. According to news reporting [...]

Published
2016

32. Investigators at University of Western Australia Report Findings in Burn Care Research (Timing of excision after a non-severe burn has a significant impact on the subsequent immune response in a murine model)

Subjects
Burns -- Research -- Models, Immune response -- Models, Health, Health care industry
Abstract

2016 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Current study results on Health and Medicine have been published. According [...]

Published
2016

33. New Findings from Center for Disease Control and Prevention Describe Advances in Virus Diseases (Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease)

Subjects
Ebola hemorrhagic fever -- Prevention -- Research -- Models -- Control, Ebola virus -- Models, Medical research -- Models, Virus diseases -- Prevention -- Research -- Models -- Control, Immune response -- Models, Health
Abstract

2016 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Investigators discuss new findings in Virus Diseases. According to news reporting out of Atlanta, Georgia, [...]

Published
2016

34. Data on Allergies Reported by Researchers at National Institute of Applied Science (Effect of a cocoa-enriched diet on immune response and anaphylaxis in a food allergy model in Brown Norway rats)

Subjects
Cocoa -- Models, Food hypersensitivity -- Models, Immune response -- Models, Health
Abstract

2016 JAN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- A new study on Allergies is now available. According to news reporting originating in Barcelona, [...]

Published
2016

35. Investigators at National Institutes of Health Discuss Findings in Lymphatic System (Modeling [F-18]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge)

Subjects
United States. National Institutes of Health, Primates -- Models, Middle East respiratory syndrome -- Models, Immune response -- Models, Health
Abstract

2015 DEC 18 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Immunology have been published. According to news reporting originating [...]

Published
2015

36. Researchers from Justus-Liebig-University Report Findings in Inflammation (Adaptive and innate immune responses in a rat orthotopic lung transplant model of chronic lung allograft dysfunction)

Subjects
Inflammation -- Research -- Models, Medical research -- Models, Organ transplantation -- Models, Immune response -- Models, Health
Abstract

2015 OCT 30 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Inflammation. According to news reporting originating in Giessen, [...]

Published
2015

37. Reports from Engelhardt Institute of Molecular Biology Provide New Insights into Colitis (Citrobacter rodentium-induced colitis: A robust model to study mucosal immune responses in the gut)

Subjects
Molecular biology -- Models, Gastrointestinal diseases -- Models, Immune response -- Models, Colitis -- Models, Biological sciences, Health
Abstract

2015 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Digestive System Diseases and Conditions. According to news reporting [...]

Published
2015

39. Studies from University of Newcastle Have Provided New Information about Irritable Bowel Syndrome (Perinatal maternal probiotic intervention impacts immune responses and ileal mucin gene expression in a rat model of irritable bowel syndrome)

Subjects
Genes -- Models, Irritable bowel syndrome -- Research -- Models, Medical research -- Models, Gastrointestinal diseases -- Research -- Models, Immune response -- Models, Gene expression -- Models, Health
Abstract

By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Digestive System Diseases and Conditions. According to news reporting out of Callaghan, Australia, by NewsRx [...]

Published
2015

40. Recent Reports from University of Pittsburgh School of Medicine Highlight Findings in Asthma (Graphene oxide attenuates Th2-type immune responses, but augments airway remodeling and hyperresponsiveness in a murine model of asthma)

Subjects
Graphene -- Models, Graphite -- Models, Immune response -- Models, Asthma -- Research -- Models, Health
Abstract

By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators discuss new findings in Obstructive Lung Diseases. According to news reporting originating in Pittsburgh, Pennsylvania, by NewsRx journalists, [...]

Published
2015

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