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The selection of group features is a critical aspect in reducing model complexity by choosing the most essential group features, while eliminating the less significant ones. The existing group feature selection methods select a set of important group features, without providing the relative importance of all group features. Moreover, few methods consider the relative importance of group features in the selection process. This study introduces a permutation-based group feature selection approach specifically designed for high-dimensional multiclass datasets. Initially, the least absolute shrinkage and selection operator (lasso) method was applied to eliminate irrelevant individual features within each group feature. Subsequently, the relative importance of the group features was computed using a random-forest-based permutation method. Accordingly, the process selected the highly significant group features. The performance of the proposed method was evaluated using machine learning algorithms and compared with the performance of other approaches, such as group lasso. We used real-world, high-dimensional, multiclass microarray datasets to demonstrate its effectiveness. The results highlighted the capability of the proposed method, which not only selected significant group features but also provided the relative importance and ranking of all group features. Furthermore, the proposed method outperformed the existing method in terms of accuracy and F1 score.

The global burden of cancer is increasing rapidly, and nanomedicine offers promising prospects for enhancing the life expectancy of cancer patients. Janus nanoparticles (JNPs) have garnered considerable attention due to their asymmetric geometry, enabling multifunctionality in drug delivery and theranostics. However, achieving precise control over the self-assembly of JNPs in solution at the nanoscale level poses significant challenges. Herein, a low-temperature reversed-phase microemulsion system was used to obtain homogenous Mn3O4-Ag2S JNPs, which showed significant potential in cancer theranostics. Structural characterization revealed that the Ag2S (5–10 nm) part was uniformly deposited on a specific surface of Mn3O4 to form a Mn3O4-Ag2S Janus morphology. Compared to the single-component Mn3O4 and Ag2S particles, the fabricated Mn3O4-Ag2S JNPs exhibited satisfactory biocompatibility and therapeutic performance. Novel diagnostic and therapeutic nanoplatforms can be guided using the magnetic component in JNPs, which is revealed as an excellent T1 contrast enhancement agent in magnetic resonance imaging (MRI) with multiple functions, such as photo-induced regulation of the tumor microenvironment via producing reactive oxygen species and second near-infrared region (NIR-II) photothermal excitation for in vitro tumor-killing effects. The prime antibacterial and promising theranostics results demonstrate the extensive potential of the designed photo-responsive Mn3O4-Ag2S JNPs for biomedical applications. [ABSTRACT FROM AUTHOR]

The study attempts to refresh the academic understanding on how often an armed conflict like Jammu and Kashmir is framed in a humane and compassionate manner by the mainstream media of the two nuclear neighboring states. A quantitative content analysis of the media coverage is carried out in terms of how frequently the perspectives of 'Others' and the less visible effects of conflict including the psychological, emotional and economic aspects are given media coverage. Ethnocentrism and framing approaches are employed as the theoretical foundation. The study concluded that majority of the news items published by all four selected English dailies of Pakistan and India were 'Us' related and covered visible aspects more frequently in comparison to the less visible aspects of J&K conflict. [ABSTRACT FROM AUTHOR]

The study tries to unfold how the Kashmir conflict is constructed in the Pakistani media after the abrogation of Article 370 of the Indian Constitution. To understand the media discourse a Critical discourse analysis of the news stories published about Indian held Kashmir (i.e. that part of the former princely state of Jammu and Kashmir occupied by India post the 1947 partition, notably the valley of Kashmir) in the e-paper of Dawn was carried out. The findings reveal a distinctive narrative strategy employed by Pakistani media in response to the abrogation of Article 370. This strategy accentuates the negative aspects of the Indian government's actions in Kashmir while simultaneously highlighting the voices of Kashmiris advocating for their right of self-determination. The findings also indicated that media discourse revolved around challenging the legitimacy of the Indian Parliament's act of abrogating Article 370 and also focused on the casualties and losses which took place as a result of clashes between the Indian security forces and the Kashmiri separatist fighters. The media also gave significance to social media trends about Indian held Kashmir and also to posts of Kashmiri and Pakistani politicians. Negative actor description was used to highlight Bharatiya Janata Party (BJP)'s propaganda regarding the return of normalcy in the Indian held Kashmir whereas positive actor description was used for the Kashmiri separatist fighters. [ABSTRACT FROM AUTHOR]

There has been a long-standing debate among scholars, policy-makers, politicians and journalists about the relationship between terrorism and the news media for whom terrorism is usually a newsworthy story. A primary focus of the debate is to investigate the media–terrorism symbiotic relationship. This paper explores this relationship through a qualitative, thematic analysis of how British TV news channels covered a major terrorist incident after the 9/11 – Mumbai attacks 2008. It examines the interpretive theme of ‘awe, terror and chaos’, and how it is selected, prioritized and developed in the presentation of the events which spread over a period of more than 72 hours. Additionally, it considers the kind of political and organizational factors that might shape or modify the editorial decision-making processes and ideological assumptions that may lie behind such coverage. Ultimately, the study maintains that British TV news outlets play an important role in mediating terrorist messages and focus primarily on images of terror and violence during the coverage of Mumbai attacks. While there are key differences between public and commercial TV news in the style and presentation of coverage, with the former being more careful in approach, the news channels concentrate on televising death and injury and the propagation of chaos and confusion in the affected city. [ABSTRACT FROM PUBLISHER]

Introduction: Newly synthesized Janus-structured Fe 3 O 4 -TiO 2 nanoparticles (NPs) appear to be a promising candidate for the diagnosis and therapy of cancer. Although the toxicity of individual Fe 3 O 4 or TiO 2 NPs has been studied extensively, the toxicity of Janus Fe 3 O 4 -TiO 2 NPs is not clear., Methods: In this study, the biosafety of both Janus Fe 3 O 4 -TiO 2 NPs (20-25 nm) and the maternal material TiO 2 NPs (7-10 nm) were evaluated in Sprague Dawley rats after one intravenous injection into the tail vein. Healthy rats were randomly divided into one control group and six experimental groups. Thirty days after treatment, rats were killed, then blood and tissue samples were collected for hematological, biochemical, element-content, histopathological, and Western blot analysis., Results: The results show that only a slight Ti element accumulation in the heart, spleen, and liver could be found in the Janus Fe 3 O 4 -TiO 2 NP groups ( P >0.05 compared with control). However, significant Ti element accumulation in the spleen, lungs, and liver was found in the TiO 2 NP-treated rats. Both Fe 3 O 4 -TiO 2 NPs and TiO 2 NPs could induce certain histopathological abnormalities. Western blot analysis showed that both NPs could induce certain apoptotic or inflammatory-related molecular protein upregulation in rat livers. A certain degree of alterations in liver function and electrolyte and lipid parameters was also observed in rats treated with both materials. However, compared to Janus structure Fe 3 O 4 -TiO 2 NP-treated groups, TiO 2 NPs at 30 mg/kg showed more severe adverse effects., Conclusion: Our results showed that under a low dose (5 mg/kg), both NP types had no significant toxicity in rats. Janus NPs certainly seem less toxic than TiO 2 NPs in rats at 30 mg/kg. To ensure safe use of these newly developed Janus NPs in cancer diagnosis and therapy, further animal studies are needed to evaluate long-term bioeffects., Competing Interests: Disclosure The authors report no conflicts of interest in this work.