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Part 12: Pathways and Tools for Digital Innovation Hubs; International audience; As digital transformation imposes cultural changes in terms of how value is delivered, continual experimentation helps define optimal solutions for key stakeholders. From the DIH perspective, the hunt is on for the most impactful and financially sustainable services that lend themselves to practical customisationagainsttarget group needs. Among these, fostering cross-border collaboration amongst themselves and between SMEs is also a desirable, albeit challenging strategy to be pursued by DIHs. We present the approach of DigiFed (European Commission funded project), which relies on a network of 12 DIHs and Research Technology Organisations (RTOs)to design and experiment with novel innovation support mechanisms for SMEs across Europe. We analyse the currently implemented cross-border cooperation instruments and their preliminary results and describe additional instruments under ongoingexperimentation. We also elaborate on prospectsto generalise these instruments for adoption by other DIH networks.

Resume Introduction La kinesitherapie est une composante majeure de la prise en charge des douleurs d’origine musculo-squelettique (DMS). Cette etude avait pour objectif d’evaluer la kinesiophobie, son impact et sa prise en charge, dans une population de patients ayant recu une prescription de kinesitherapie pour des DMS. Methodes Une etude nationale prospective multicentrique a ete menee en France chez des patients ayant recu une prescription de kinesitherapie pour des DMS. Le score de kinesiophobie a ete mesure sur l’echelle de Tampa (Tampa Scale of Kinesiophobia [TSK]). La douleur, la satisfaction, la consommation d’antalgiques ont ete evaluees a la premiere visite, a la 5 e seance de kinesitherapie puis a la sortie du programme de reeducation. Resultats Sept cents patients consecutifs souffrant de DMS, dont 54,5 % de femmes, ayant recu une prescription de kinesitherapie, ont ete inclus par 186 medecins generalistes (MG) : 501 avaient un score eleve de kinesiophobie (score TSK > 40). Les patients presentant une kinesiophobie etaient significativement plus âges, avec une activite physique reduite, des douleurs plus intenses et une faible acceptabilite de la douleur. Les patients inclus par un MG ayant une kinesiophobie averee avaient des douleurs et un score de kinesiophobie plus eleves. A l’issue de la 5 e seance de kinesitherapie, la satisfaction globale etait significativement plus elevee chez les patients sans kinesiophobie. On notait une amelioration significative de la satisfaction chez les patients ayant recu une prescription preventive d’antalgiques avant la kinesitherapie, c’est-a-dire 25,6 % d’entre eux. Les facteurs predictifs independants de la prise en charge specifique des douleurs induites par la kinesitherapie etaient : kinesiophobie du patient (OR = 2,02 [1,07–3,82]), traitement antalgique en cours (OR = 2,05 [1,16–3,63]), medecin generaliste ayant suivi un cursus post-these sur la douleur (OR = 2,65 [1,29–5,43]), medecin generaliste exercant dans le secteur prive (OR = 1,88 [1,01–3,48]). Conclusion La kinesiophobie est un processus frequent chez les patients souffrant de DMS, il est associe a la kinesiophobie du MG et diminue la satisfaction du patient vis-a-vis de la kinesitherapie. Une prescription antalgique preventive avant les seances de reeducation permet d’augmenter la satisfaction des patients et doit etre proposee en vue d’ameliorer la prise en charge des DMS.

International audience; Objectives: To describe the management of glucose-lowering agents in people with type 2 diabetes initially on oral monotherapy, cared for by French general practitioners, and to identify reasons underlying treatment non-intensification.Methods: People with type 2 diabetes on oral monotherapy were recruited by general practitioners and followed-up over 12 months. Patient characteristics, HbA1c, and glucose-lowering treatments were recorded electronically. Management objectives and reasons for treatment non-intensification were solicited from the general practitioners.Results: A total of 1212 patients were enrolled by 198 general practitioners; 937 patients (mean age 68 years) were treated with oral monotherapy, and 916 patients had at least two successive HbA1c values recorded. Of these, 390 patients (43%) had HbA1c ≥ 6.5% on both occasions, and 164/390 (42%) had their treatment intensified. The 226 patients whose treatment was not intensified were older (69 ± 11 years vs. 66 ± 12 years, P = 0.02) and had better glycaemic control at study inclusion (6.9% ± 0.6 vs. 7.3% ± 0.8, P < 0.0001) than treatment intensified patients. Among uncontrolled patients, there were no differences in general practitioner treatment objectives at inclusion for treatment intensified and non-intensified patients; the main reason given by general practitioners for non-intensification was that the patient had an adequate HbA1c (66%). HbA1c did exceed the 6.5% target, but was less than 7.0% in 69% of cases.Conclusions: General practitioners showed a patient-centred approach to treatment, but clinical inertia was apparent for 31% of the uncontrolled patients.; Objectifs: Décrire les pratiques des médecins généralistes français concernant l’intensification du traitement des diabétiques de type 2 mal-équilibrés et traités au départ par hypoglycémiants oraux en monothérapie et identifier les raisons d’une non-intensification du traitement.Méthodes: Des diabétiques de type 2 sous monothérapie orale ont été recrutés par des médecins généralistes et suivis pendant 12 mois; leurs caractéristiques, HbA1c et traitements hypoglycémiants ont été enregistrés par électronique. Les objectifs de prise en charge par les médecins généralistes et les raisons d’une non-intensification de traitement ont été notés.Résultats: Un total de 1212 patients avec un diabète de type 2 ont été recrutés par 198 généralistes ; 937 (âge moyen 68 ans) ont été traités par hypoglycémiant oral en monothérapie, parmi lesquels 916 ont eu au moins deux mesures successives d’HbA1c. Parmi eux, 390 (43 %) ont présenté une HbA1c ≥ 6,5 % deux fois au cours du suivi, et 164/390 (42 %) ont bénéficié d’une intensification de traitement. Les 226 patients n’ayant pas bénéficié de cette intensification étaient plus âgés (69 ± 11 vs 66 ± 12 ans, p = 0,02) et présentaient une meilleur équilibre glycémique à l’inclusion (6,9 % ± 0,6 vs 7,3 % ± 0,8, p < 0,0001). Parmi les patients non-équilibrés, il n’y avait pas de différence des objectifs de traitement à l’inclusion selon qu’ils aient bénéficié d’un traitement intensifié ou pas ; les raisons d’une non-intensification étaient que l’HbA1c (66 %) étaient adéquates. En effet, l’HbA1c dépassaient la valeur cible de 6,5 % de moins de 0,5 % dans 69 % des cas.Conclusions: Les médecins généralistes ont montré une approche centrée sur leur patient. Pour 31 % des patients mal-équilibrés, une inertie thérapeutique a toutefois été notée.

Introduction Physical therapy (PT) represents a major approach in musculoskeletal (MSK) pain. This study aimed to assess kinesiophobia, its impact and management, in patients with MSK pain treated by PT. Methods A national multicenter, prospective study was conducted in France in patients with MSK pain referred to PT. Kinesiophobia was scored with the Tampa Scale of Kinesiophobia (TSK). Pain, satisfaction, analgesic intake and acceptability were assessed at the initial visit, at the 5th PT session, and at the end of PT. Results A total of 700 consecutive outpatients with MSK pain, 54.5% female, referred to PT were recruited by 186 GPs: 501 had significant levels of kinesiophobia (TSK score > 40). Patients with kinesiophobia were significantly older, with less physical activity, more pain and less acceptability. Patients from GPs presenting with kinesiophobia had both higher pain and kinesiophobia levels. After 5 PT sessions, global satisfaction was significantly higher in patients without kinesiophobia. A significant increase of PT satisfaction was observed in patients who had been given preventive analgesics before PT sessions, in 25.6% of patients. Independent predictors for specific management of PT-induced pain were: patient's kinesiophobia (OR = 2.02 [1.07–3.82]), current analgesics treatment (OR = 2.05 [1.16–3.63]), GP with postgraduate course on pain (OR = 2.65 [1.29–5.43]), GP's independent practice (OR = 1.88 [1.01–3.48]). Conclusion Kinesiophobia is frequent in patients with MSK pain, is associated to GPs’ kinesiophobia and decreases satisfaction of physical therapy. Preventive analgesic treatment before PT sessions improves patients’ satisfaction and should be proposed to improve MSK pain management.

This paper presents the first printed organic 13-MHz RFID on flexible substrate. The proposed solution includes a planar near field antenna bonded to an RFID tag, which is printed on flexible foil using an organic complementary TFT technology. Thanks to an active envelope detector, ASK modulation with modulation depth as low as 20% can be adopted to increase the available input power for the rectifier. The RFID functionality is demonstrated at the internally generated supply voltage of 24 V, for a reading range of 2-5 cm and a bit-rate up to 50 bit/s. With more than 250 transistors on the same foil, this work represents the most complex circuit ever published in a printed organic complementary TFT technology.

We studied the capacitance characteristics of printed p-type organic thin-film transistors (OTFTs) under vari- ous frequencies and dc bias conditions. The experimental results show that the device capacitance is largely influenced by parasitic capacitances, related to the large gate-active layer overlap areas required by the printing processes. We developed a nonquasi- static small-signal capacitance model that adopts a transmission line approach and considers the specific layout of the OTFTs, taking into account for the parasitic capacitances and, hence, is particularly well suited for printed devices. In addition, the model included parasitic impedance at the metal-organic semiconductor contacts, related to the nonohmic behavior of source-drain contacts. The model has been shown to nicely reproduce the experimental capacitance characteristics in all their features. It should be pointed out that the proposed model allows the reproducing of any device layout and could be implemented in device simulator to analyze small-signal dynamic characteristics.