1. Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study
- Author
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Chan yuan Ye, Huan Cai, Guo dong Yu, Shao rui Hao, Jianhua Hu, Shan yan Zhang, Ren Yan, Jiang shan Lian, Lin Zheng, Jiao jiao Xin, Ji Fang Sheng, Ci liang Jin, Yi da Yang, Jue qing Gu, Xiaoli Zhang, Hongyu Jia, and Ying feng Lu
- Subjects
0301 basic medicine ,medicine.medical_treatment ,Gastroenterology ,law.invention ,0302 clinical medicine ,law ,严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) ,Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Inhalation ,Articles ,Interferon (IFN) ,General Medicine ,倾向性评分 ,Intensive care unit ,Virus Shedding ,Hospitalization ,Diarrhea ,C-Reactive Protein ,030220 oncology & carcinogenesis ,medicine.symptom ,Coronavirus Infections ,Propensity score match ,China ,medicine.medical_specialty ,Pneumonia, Viral ,Interferon alpha-2 ,Antiviral Agents ,General Biochemistry, Genetics and Molecular Biology ,Betacoronavirus ,03 medical and health sciences ,Albumins ,Internal medicine ,Humans ,Viral shedding ,Propensity Score ,R184 ,Glucocorticoids ,Pandemics ,Retrospective Studies ,General Veterinary ,SARS-CoV-2 ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Sodium ,Case-control study ,COVID-19 ,Retrospective cohort study ,Nasal Sprays ,干扰素 ,COVID-19 Drug Treatment ,Coronavirus disease 2019 (COVID-19) ,匹配 ,030104 developmental biology ,Nasal spray ,Case-Control Studies ,Propensity score matching ,business ,2019 冠状病毒病 (COVID-19) - Abstract
Background Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a potential therapeutic agent for treatment of coronavirus disease 2019 (COVID-19), especially while COVID-19-specific therapies are still under development. Methods Confirmed COVID-19 patients hospitalized in the First Affiliated Hospital, School of Medicine, Zhejiang University in Hangzhou, China, from January 19 to February 19, 2020 were enrolled in a retrospective study. The patients were separated into an IFN group and a control group according to whether they received initial IFN-α2b inhalation treatment after admission. Propensity-score matching was used to balance the confounding factors. Results A total of 104 confirmed COVID-19 patients, 68 in the IFN group and 36 in the control group, were enrolled. Less hypertension (27.9% vs. 55.6%, P=0.006), dyspnea (8.8% vs. 25.0%, P=0.025), or diarrhea (4.4% vs. 19.4%, P=0.030) was observed in the IFN group. Lower levels of albumin and C-reactive protein and higher level of sodium were observed in the IFN group. Glucocorticoid dosage was lower in the IFN group (median, 40 vs. 80 mg/d, P=0.025). Compared to the control group, fewer patients in the IFN group were ventilated (13.2% vs. 33.3%, P=0.015) and admitted to intensive care unit (ICU) (16.2% vs. 44.4%, P=0.002). There were also fewer critical patients in the IFN group (7.4% vs. 25.0%, P=0.017) upon admission. Although complications during admission process were comparable between groups, the discharge rate (85.3% vs. 66.7%, P=0.027) was higher and the hospitalization time (16 vs. 21 d, P=0.015) was shorter in the IFN group. When other confounding factors were not considered, virus shedding time (10 vs. 13 d, P=0.014) was also shorter in the IFN group. However, when the influence of other factors was eliminated using propensity score matching, virus shedding time was not significantly shorter than that of the control group (12 vs. 15 d, P=0.206). Conclusions IFN-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients.
- Published
- 2020