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2. Long-term survival for lymphoid neoplasms and national health expenditure (EUROCARE-6): a retrospective, population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejici, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Pitkäniemi, Janne, Velten, Michel, Troussard, Xavier, Bouvier, Anne-Marie, Jooste, Valerie, Guizard, Anne-Valérie, Launoy, Guy, Dabakuyo Yonli, Sandrine, Maynadié, Marc, Woronoff, Anne-Sophie, Nousbaum, Jean-Baptiste, Coureau, Gaëlle, Monnereau, Alain, Baldi, Isabelle, Hammas, Karima, Tretarre, Brigitte, Colonna, Marc, Plouvier, Sandrine, D'Almeida, Tania, Molinié, Florence, Cowppli-Bony, Anne, Bara, Simona, Debreuve, Adeline, Defossez, Gautier, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Daubisse-Marliac, Laetitia, Luttmann, Sabine, Eberle, Andrea, Stabenow, Roland, Nennecke, Alice, Kieschke, Joachim, Zeissig, Sylke, Holleczek, Bernd, Katalinic, Alexander, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M, Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotti, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Ragusa, Rosalia, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Buratti, Lucia, Tagliabue, Giovanna, Serraino, Diego, Dal Maso, Luigino, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Cerza, Francesco, Di Mari, Fabrizio, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Gennaro, Valerio, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Mazzucco, Walter, Michiara, Maria, Chiranda, Giorgio, Cascone, Giuseppe, Rollo, Concetta Patrizia, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Madeddu, Anselmo, Bella, Francesca, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Bento, Maria José, Ferreira, Ana Maia, Lourenço, António, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, María Dolores, Aleman, Araceli, Vizcaino, Ana, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque Lopez, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Galceran, Jaume, Carulla, Maria, Bergeron, Yvan, Bouchardy, Christine, Mohsen Mousavi, Seyed, Went, Philip, Blum, Marcel, Bordoni, Andrea, Visser, Otto, Stevens, Sarah, Broggio, John, Bennett, Damien, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Paapsi, Keiu, Mousavi, Seyed Mohsen, and Sánchez, Maria-Jose

Published
2024
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5. Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): a population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejici, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Pitkäniemi, Janne, Velten, Michel, Troussard, Xavier, Bouvier, Anne-Marie, Jooste, Valerie, Guizard, Anne-Valérie, Launoy, Guy, Dabakuyo Yonli, Sandrine, Maynadié, Marc, Woronoff, Anne-Sophie, Nousbaum, Jean-Baptiste, Coureau, Gaëlle, Monnereau, Alain, Baldi, Isabelle, Hammas, Karima, Tretarre, Brigitte, Colonna, Marc, Plouvier, Sandrine, D'Almeida, Tania, Molinié, Florence, Cowppli-Bony, Anne, Bara, Simona, Debreuve, Adeline, Defossez, Gautier, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Daubisse-Marliac, Laetitia, Luttmann, Sabine, Stabenow, Roland, Nennecke, Alice, Kieschke, Joachim, Zeissig, Sylke, Holleczek, Bernd, Katalinic, Alexander, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M., Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotti, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Ragusa, Rosalia, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Buratti, Lucia, Tagliabue, Giovanna, Serraino, Diego, Dal Maso, Luigino, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Gennaro, Valerio, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Mazzucco, Walter, Michiara, Maria, Chiranda, Giorgio, Cascone, Giuseppe, Giurdanella, Maria Concetta, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Madeddu, Anselmo, Bella, Francesca, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Bento, Maria José, Calisto, Rita, Lourenço, António, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, Marìa Dolores, Aleman, Araceli, Vizcaino, Ana, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque Lopez, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Galceran, Jaume, Carulla, Maria, Bergeron, Yvan, Bouchardy, Christine, Mohsen Mousavi, Seyed, Went, Philip, Blum, Marcel, Bordoni, Andrea, Visser, Otto, Stevens, Sarah, Broggio, John, Bennett, Damien, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Ventura, Leonardo, Paapsi, Keiu, Randi, Giorgia, Bettio, Manola, and Guzzinati, Stefano

Published
2024
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6. Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era

Author

Johansson, Anna L.V., Skog, Anna, Johannesen, Tom Børge, Myklebust, Tor Åge, Skovlund, Charlotte Wessel, Mørch, Lina Steinrud, Friis, Søren, Gamborg, Mads, Kristiansen, Marnar Fríðheim, Pettersson, David, Ólafsdóttir, Elínborg J., Birgisson, Helgi, Palsson, Runolfur, Eythorsson, Elias, Irenaeus, Sandra, Lambe, Mats, and Ursin, Giske

Published
2023
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11. Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study

Author

Cardoso, Rafael, Guo, Feng, Heisser, Thomas, Hackl, Monika, Ihle, Petra, De Schutter, Harlinde, Van Damme, Nancy, Valerianova, Zdravka, Atanasov, Trajan, Májek, Ondřej, Mužík, Jan, Nilbert, Mef Christina, Tybjerg, Anne Julie, Innos, Kaire, Mägi, Margit, Malila, Nea, Bouvier, Anne-Marie, Bouvier, Véronique, Launoy, Guy, Woronoff, Anne-Sophie, Cariou, Mélanie, Robaszkiewicz, Michel, Delafosse, Patricia, Poncet, Florence, Katalinic, Alexander, Walsh, Paul M, Senore, Carlo, Rosso, Stefano, Vincerževskienė, Ieva, Lemmens, Valery E P P, Elferink, Marloes A G, Johannesen, Tom Børge, Kørner, Hartwig, Pfeffer, Frank, Bento, Maria José, Rodrigues, Jessica, Alves da Costa, Filipa, Miranda, Ana, Zadnik, Vesna, Žagar, Tina, Lopez de Munain Marques, Arantza, Marcos-Gragera, Rafael, Puigdemont, Montse, Galceran, Jaume, Carulla, Marià, Chirlaque, María-Dolores, Ballesta, Monica, Sundquist, Kristina, Sundquist, Jan, Weber, Marco, Jordan, Andrea, Herrmann, Christian, Mousavi, Mohsen, Ryzhov, Anton, Hoffmeister, Michael, and Brenner, Hermann

Published
2021
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16. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet—a population-based study

Author

Hackl, Monika, Henau, Kris, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Paapsi, Keiu, Malila, Nea, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, SchubertFritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, Collarile, Paolo, Pannozzo, Fabio, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Caiazzo, Anna Luisa, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Colanino, Antonino Ziino, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Baili, Paolo, Minicozzi, Pamela, Sant, Milena, Tereanu, Carmen, Francisci, Silvia, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Agius, Dominic, Johannesen, Tom Børge, Rachtan, Jadwiga, Gózdz, Stanislaw, Blaszczyk, Jerzy, Kepska, Kamila, Lacerda, Gonçalo Forjaz de, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Žagar, Tina, Almar, Enrique, Larrañaga, Nerea, Munain, Arantza Lopez de, Torrella-Ramos, Ana, García, José María Díaz, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H, Huws, Dyfed Wyn, Ho, Vincent KY, Benhamou, Ellen, Gatta, Gemma, Capocaccia, Riccardo, Botta, Laura, Mallone, Sandra, De Angelis, Roberta, Ardanaz, Eva, Comber, Harry, Dimitrova, Nadya, Leinonen, Maarit K, Siesling, Sabine, van der Zwan, Jan M, Van Eycken, Liesbet, Visser, Otto, Žakelj, Maja P, Anderson, Lesley A, Bella, Francesca, Kaire, Innos, Otter, Renée, Stiller, Charles A, and Trama, Annalisa

Published
2017
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17. Were cancer patients worse off than the general population during the COVID-19 pandemic? : A population-based study from Norway, Denmark and Iceland during the pre-vaccination era

Author

Johansson, Anna L., V, Skog, Anna, Johannesen, Tom Borge, Myklebust, Tor age, Skovlund, Charlotte Wessel, Morch, Lina Steinrud, Friis, Soren, Gamborg, Mads, Kristiansen, Marnar Frioheim, Pettersson, David, Olafsdottir, Elinborg J., Birgisson, Helgi, Palsson, Runolfur, Eythorsson, Elias, Irenaeus, Sandra, Lambe, Mats, Ursin, Giske, Johansson, Anna L., V, Skog, Anna, Johannesen, Tom Borge, Myklebust, Tor age, Skovlund, Charlotte Wessel, Morch, Lina Steinrud, Friis, Soren, Gamborg, Mads, Kristiansen, Marnar Frioheim, Pettersson, David, Olafsdottir, Elinborg J., Birgisson, Helgi, Palsson, Runolfur, Eythorsson, Elias, Irenaeus, Sandra, Lambe, Mats, and Ursin, Giske

Abstract

Background In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.Methods In nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who tested positive for SARS-CoV-2 or had a severe COVID-19 outcome (hospitalisation, intensive care, and death) from March until December 2020, using data from national health registries. We estimated standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) comparing cancer patients with the general population.Findings During the first wave of the pandemic, cancer patients in Norway and Denmark had higher risks of testing SARS-CoV-2 positive compared to the general population. Throughout 2020, recently treated cancer patients were more likely to test SARS-CoV-2 positive. In Iceland, cancer patients experienced no increased risk of testing positive. The risk of COVID-19-related hospitalisation was higher among cancer patients diagnosed within one year of hospitalisation (Norway: SIR = 2.43, 95% CI 1.89-3.09; Denmark: 2.23, 1.96-2.54) and within five years (Norway: 1.58, 1.35-1.83; Denmark: 1.54, 1.42-1.66). Risks were higher in recently treated cancer patients and in those diagnosed with haematologic malignancies, colorectal or lung cancer. Risks of COVID-19-related intensive care and death were higher among cancer patients. Interpretation Cancer patients were at increased risk of testing positive for SARS-CoV-2 during the first pandemic wave when testing availability was limited, while relative risks of severe COVID-19 outcomes remained increased in cancer patients throughout 2020. Recent cancer treatment and haematologic malignancy were the strongest risk factors.

Published
2023
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21. Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants : a nested case-control study

Author

Späth, Florentin, Andersson, Ulrika, Dahlin, Anna M., Langseth, Hilde, Hovig, Eivind, Johannesen, Tom Borge, Grankvist, Kjell, Björkblom, Benny, Wibom, Carl, Melin, Beatrice, Späth, Florentin, Andersson, Ulrika, Dahlin, Anna M., Langseth, Hilde, Hovig, Eivind, Johannesen, Tom Borge, Grankvist, Kjell, Björkblom, Benny, Wibom, Carl, and Melin, Beatrice

Abstract

Genetic variants have been associated with the risk of developing glioma, but functional mechanisms on disease phenotypic traits remain to be investigated. One phenotypic trait of glioblastoma is the mutation and amplification of the epidermal growth factor receptor (EGFR) gene. We investigated associations between pre-diagnostic serum protein concentrations of EGFR and ErbB2, both members of the EGFR family, and future risk of glioma. Further, we studied if EGFR glioma risk variants were associated with EGFR and ErbB2 serum levels. We assessed the associations between genetic glioma risk variants and serum concentrations of EGFR and ErbB2, as measured in pre-diagnostic cohort serum samples of 593 glioma patients and 590 matched cancer-free controls. High serum EGFR and ErbB2 levels were associated with risk of developing glioblastoma (P = 0.008; OR = 1.58, 95 % CI = 1.13-2.22 and P = 0.017, OR = 1.63, 95 % CI = 1.09-2.44, respectively). High serum ErbB2 concentration was also associated with glioma risk overall (P = 0.049; OR = 1.39, 95 % CI = 1.00-1.93). Glioma risk variants were not associated with high serum protein abundance. In contrast, the EGFR risk variant rs4947986 (T) was correlated with decreased EGFR serum levels (study cohort P = 0.024 and controls P = 0.009). To our knowledge, this is the first study showing an association of EGFR and ErbB2 serum levels with glioma more than a decade before diagnosis, indicating that EGFR and ErbB2 serum proteins are important in early gliomagenesis. However, we did not find evidence that glioma risk variants were associated with high pre-diagnostic serum concentrations of EGFR and ErbB2.

Published
2016
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22. Metabolomic screening of pre-diagnostic serum samples identifies association between alpha- and gamma-tocopherols and glioblastoma risk

Author

Björkblom, Benny, Wibom, Carl, Jonsson, Pär, Mörén, Lina, Andersson, Ulrika, Johannesen, Tom Borge, langseth, Hilde, Antti, Henrik, Melin, Beatrice, Björkblom, Benny, Wibom, Carl, Jonsson, Pär, Mörén, Lina, Andersson, Ulrika, Johannesen, Tom Borge, langseth, Hilde, Antti, Henrik, and Melin, Beatrice

Abstract

Glioblastoma is associated with poor prognosis with a median survival of one year. High doses of ionizing radiation is the only established exogenous risk factor. To explore new potential biological risk factors for glioblastoma, we investigated alterations in metabolite concentrations in pre-diagnosed serum samples from glioblastoma patients diagnosed up to 22 years after sample collection, and undiseased controls. The study points out a latent biomarker for future glioblastoma consisting of nine metabolites (gamma-tocopherol, alpha-tocopherol, erythritol, erythronic acid, myo-inositol, cystine, 2-keto-L-gluconic acid, hypoxanthine and xanthine) involved in antioxidant metabolism. We detected significantly higher serum concentrations of alpha-tocopherol (p=0.0018) and gamma-tocopherol (p=0.0009) in future glioblastoma cases. Compared to their matched controls, the cases showed a significant average fold increase of alpha- and gamma-tocopherol levels: 1.2 for alpha-T (p=0.018) and 1.6 for gamma-T (p=0.003). These tocopherol levels were associated with a glioblastoma odds ratio of 1.7 (alpha-T, 95% CI: 1.0-3.0) and 2.1 (gamma-T, 95% CI: 1.2-3.8). Our exploratory metabolomics study detected elevated serum levels of a panel of molecules with antioxidant properties as well as oxidative stress generated compounds. Additional studies are necessary to confirm the association between the observed serum metabolite pattern and future glioblastoma development.

Published
2016
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23. Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma

Author

Schwartzbaum, Judith, primary, Seweryn, Michal, additional, Holloman, Christopher, additional, Harris, Randall, additional, Handelman, Samuel K., additional, Rempala, Grzegorz A., additional, Huang, Ruo-Pan, additional, Burkholder, Brett, additional, Brandemihl, Adam, additional, Kallberg, Henrik, additional, Johannesen, Tom Borge, additional, Ahlbom, Anders, additional, Feychting, Maria, additional, and Grimsrud, Tom K., additional

Published
2015
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24. Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma

Author

Zigmont, Victoria, primary, Garrett, Amy, additional, Peng, Jin, additional, Seweryn, Michal, additional, Rempala, Grzegorz A., additional, Harris, Randall, additional, Holloman, Christopher, additional, Gundersen, Thomas E., additional, Ahlbom, Anders, additional, Feychting, Maria, additional, Johannesen, Tom Borge, additional, Grimsrud, Tom Kristian, additional, and Schwartzbaum, Judith, additional

Published
2015
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