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A trinuclear copper complex [Cu3(napxshz)2(phen)2] has been synthesised using a tribasic naproxen‐appended ligand [H3napxshz = 2‐hydroxy‐N′‐(2‐[6‐methoxynaphthalen‐2‐yl] propanoyl) benzohydrazide] and 1,10‐phenanthroline. The complex was characterised by different spectroscopic methods such as Fouriertransform infrared (FT‐IR), ultraviolet‐visible (UV–Vis) and electrospray ionisation (ESI)‐mass spectroscopy. The solid‐state structure of the ligand and complex 1 was established by single‐crystal X‐ray diffraction analysis. The interaction of the complex and the ligand with DNA was investigated by UV–visible spectroscopy and fluorometric titrations. The calculated binding constants (Kb) of the complex and the ligand with ct‐DNA show that the complex has a higher binding affinity than the ligand H3napxshz. Quantum chemical calculations were performed to understand the structural aspects of the complex and its interactions with DNA. The molecular docking study reveals the interaction between DNA, and the complex is in intercalative mode. [ABSTRACT FROM AUTHOR]

A Pd6L8 type coordination driven self-assembly was constructed using a tripodal ligand L (L = N1,N3,N5-trimethyl-N1,N3,N5-tris[(pyridin-4-yl)methyl]-1,3,5-benzene tricarboxamide) and palladium nitrate. The self-assembly was fully characterised using one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance spectroscopy, electrospray ionization-mass spectroscopy, thermogravimetric analysis, energy-dispersive X-ray spectroscopy and elemental analysis. Use of high resolution transmission electron microscopy (HR-TEM) analysis confirms the discrete nature of the assembly with a dimension of ∼2.8 nm, consistent with the density functional theory optimised structure. The assembly acts as an efficient homogeneous catalyst for a copper and phosphine free Sonogashira reaction under mild and aerobic conditions in aqueous medium. The catalyst shows equal efficiency for both electron deficient and electron rich aryl iodides and bromides and is also suitable for use with aliphatic alkynes. The utility of the catalyst as a reusable heterogeneous catalyst in toluene was assessed up to the 3rd cycle without any significant loss of catalytic activity. [ABSTRACT FROM AUTHOR]