1. Do dietary patterns determine levels of vitamin B6, folate, and vitamin B12 intake and corresponding biomarkers in European adolescents? The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
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Iris Iglesia, Inge Huybrechts, Theodora Mouratidou, Javier Santabárbara, Juan M. Fernández-Alvira, Alba M. Santaliestra-Pasías, Yannis Manios, Alejandro De la O Puerta, Anthony Kafatos, Frédéric Gottrand, Ascensión Marcos, Stefania Sette, Maria Plada, Peter Stehle, Dénes Molnár, Kurt Widhalm, Mathilde Kersting, Stefaan De Henauw, Luis A. Moreno, Marcela González-Gross, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús M.a Garagorri, Manuel Bueno, Idoia Labayen, Silvia Bel, Luis A. Gracia Marco, Alba Santaliestra-Pasías, Esther González-Gil, Pilar De Miguel-Etayo, Cristina Julián Almárcegui, Mary Miguel-Berges, Isabel Iguacel, Julia Wärnberg, Esther Nova, Sonia Gómez, Ligia Esperanza Díaz, Javier Romeo, Ana Veses, Belén Zapatera, Tamara Pozo, David Martínez, Laurent Beghin, Christian Libersa, Catalina Iliescu, Juliana Von Berlepsch, Wolfgang Sichert-Hellert, Ellen Koeppen, Eva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Mrs Angster, Enikö Nagy, Orsolya Kovács, Judit Répasi, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas, Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Klaus Pietrzik, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J. Castillo, Ángel Gutiérrez, Francisco B. Ortega, Jonatan R. Ruiz, Enrique G. Artero, Vanesa España, David Jiménez-Pavón, Palma Chillón, Cristóbal Sánchez-Muñoz, Magdalena Cuenca, Davide Arcella, Elena Azzini, Emma Barison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D'Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Romana Roccaldo, Raffaella Spada, Maria Zaccaria, Luca Scalfi, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Tineke De Vriendt, Lea Maes, Christophe Matthys, Carine Vereecken, Mieke de Maeyer, Charlene Ottevaere, Katharina Phillipp, Sabine Dietrich, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Stamatoula Tsikrika, Christos Karaiskos, Jean Dallongeville, Aline Meirhaeghe, Michael Sjöstrom, María Hagströmer, Anita Hurtig Wennlöf, Lena Hallström, Emma Patterson, Lydia Kwak, Nico Rizzo, Jackie Sánchez-Molero, Sara Castelló, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Chantal Gilbert, Sarah Thomas, Elaine Allchurch, Peter Burgess, Gunnar Hall, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Raquel Pedrero-Chamizo, Agustín Meléndez, Jara Valtueña, Ulrike Albers, Pedro J. Benito, Juan José Gómez Lorente, David Cañada, Alejandro Urzanqui, Rosa María Torres, Paloma Navarro, European Commission, Ministerio de Educación (España), Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Iglesia, Iri, Huybrechts, Inge, Mouratidou, Theodora, Santabárbara, Javier, Fernández-Alvira, Juan M., Santaliestra-Pasías, Alba M., Manios, Yanni, De la O Puerta, Alejandro, Kafatos, Anthony, Gottrand, Frédéric, Marcos, Ascensión, Sette, Stefania, Plada, Maria, Stehle, Peter, Molnár, Déne, Widhalm, Kurt, Kersting, Mathilde, De Henauw, Stefaan, Moreno, Luis A., González-Gross, Marcela, Fleta, Jesú, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús M. a, Bueno, Manuel, Labayen, Idoia, Bel, Silvia, Marco, Luis A. Gracia, Santaliestra-Pasías, Alba, González-Gil, Esther, De Miguel-Etayo, Pilar, Almárcegui, Cristina Julián, Miguel-Berges, Mary, Iguacel, Isabel, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Ligia Esperanza, Romeo, Javier, Veses, Ana, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Libersa, Christian, Iliescu, Catalina, Von Berlepsch, Juliana, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Mr, Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christo, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manoli, Protoyeraki, Eva, Fasoulaki, Maria, Pietrzik, Klau, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Sánchez-Muñoz, Cristóbal, Cuenca, Magdalena, Arcella, Davide, Azzini, Elena, Barison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D'Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Donne, Cinzia Le, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Roccaldo, Romana, Spada, Raffaella, Zaccaria, Maria, Scalfi, Luca, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Phillipp, Katharina, Dietrich, Sabine, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Tsikrika, Stamatoula, Karaiskos, Christo, Dallongeville, Jean, Meirhaeghe, Aline, Sjöstrom, Michael, Hagströmer, María, Wennlöf, Anita Hurtig, Hallström, Lena, Patterson, Emma, Kwak, Lydia, Rizzo, Nico, Sánchez-Molero, Jackie, Castelló, Sara, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Gilbert, Chantal, Thomas, Sarah, Allchurch, Elaine, Burgess, Peter, Hall, Gunnar, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andra, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mat, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Pedrero-Chamizo, Raquel, Meléndez, Agustín, Valtueña, Jara, Albers, Ulrike, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Torres, Rosa María, and Navarro, Paloma
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0301 basic medicine ,Vitamin b ,Food intake ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Adolescent ,business.industry ,Endocrinology, Diabetes and Metabolism ,Physiology ,Dietary pattern ,Reduced rank regression ,Fish products ,Whole milk ,Europe ,03 medical and health sciences ,Medicine ,Biomarker (medicine) ,Vitamin B12 ,Vitamin b6 ,business ,Vitamin B - Abstract
On behalf of the HELENA study group: et al., [Objectives]: To determine dietary patterns (DPs) and explain the highest variance of vitamin B6, folate, and B12 intake and related concentrations among European adolescents., [Methods]: A total of 2173 adolescents who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence study met the eligibility criteria for the vitamin B intake analysis (46% boys) and 586 adolescents for the biomarkers analysis (47% boys). Two non-consecutive, 24-h, dietary recalls were used to assess the mean intakes. Concentrations were measured by chromatography and immunoassay testing. A reduced rank regression was applied to elucidate the combined effect of food intake of vitamin B and related concentrations., [Results]: The identified DPs (one per vitamin B intake and biomarker and by sex) explained a variability between 34.2% and 23.7% of the vitamin B intake and between 17.2% and 7% of the biomarkers. In the reduced rank regression models, fish, eggs, cheese, whole milk and buttermilk intakes were loaded positively for vitamin B intake in both sexes; however, soft drinks and chocolate were loaded negatively. For the biomarkers, a higher variability was observed in the patterns in terms of food loads such as alcoholic drinks, sugars, and soft drinks. Some food items were loaded differently between intakes and biomarkers such as fish products, which was loaded positively for intakes but negatively for plasma folate in girls., [Conclusions]: The identified DPs explained up to 34.2% and 17.2% of the variability of the vitamin B intake and plasma concentrations, respectively, in European adolescents. Further studies are needed to elucidate the factors that determine such patterns., HELENA study received funding from the European Union’s Sixth RTD Framework Programme (Contract FOODCT-2005-007034). Additional support from the Spanish Ministry of Education (AGL2007-29784-E/ALI), Axis-Shield Diagnostics Ltd (Oslo, Norway), Abbot Científica S.A. (Spain). This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) with the contribution of the European Regional Development Fund (FEDER). The first author is supported by a grant from the Spanish Carlos III Health Institute: RD08/0072/0025 (Red SAMID: Maternal, Child Health and Development Research Network).
- Published
- 2018