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Your search keyword '"Karina I. Acevedo"' showing total 2 results
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2 results on '"Karina I. Acevedo"'

1. Depression, Anxiety, and Social Environmental Adversity as Potential Modulators of the Immune Tumor Microenvironment in Breast Cancer Patients

Author

Eida M. Castro-Figueroa, Karina I. Acevedo, Cristina I. Peña-Vargas, Normarie Torres-Blasco, Idhaliz Flores, Claudia B. Colón-Echevarria, Lizette Maldonado, Zindie Rodríguez, Alexandra N. Aquino-Acevedo, Heather Jim, María I. Lazaro, and Guillermo N. Armaiz-Peña

Subjects
tumor microenvironment, breast cancer, depression, anxiety, immune cells, social environmental adversity, Medicine
Abstract

Background: Mounting data suggest that exposure to chronic stress is associated with worse breast cancer outcomes. This study aimed to explore the impact of social environmental adversity (SEA, e.g., child abuse, crime, sexual, and physical violence), depressive symptomatology, and anxiety on immune cell infiltration into the breast tumor microenvironment. Methods: Participants (n = 33) completed a series of surveys assessing depression and anxiety symptoms, adverse childhood events (ACE), and trauma history. Tumor-associated macrophages (CD68+), B cells (CD19+), and T cells (CD3+) were identified by immunohistochemical analyses of formalin-fixed paraffin-embedded tumor samples and quantified. Spearman rank tests were used to explore the relationships between the variables studied. Results: Exposure to SEA was high (ACE = 72%, exposure to crime = 47%, and exposure to physical/sexual assault = 73%) among participants. Moreover, 30% reported a comorbid history of depression and ACE; 39% reported one or more traumatic events, and clinically significant depression symptomatology, while 21% reported trauma history and significant anxiety symptomatology. Increased tumor-infiltrating B cells were significantly correlated with exposure to crime, anxiety symptoms, and exposure to an ACE. The ACE plus anxiety group presented the highest infiltration of B cells, T cells, and macrophages. Conclusion: These findings support a role for SEA, anxiety symptoms, and depression as potential modulators of the immune tumor microenvironment in breast cancer.

Published
2021
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2. Spiritual well‐being, distress and quality of life in Hispanic women diagnosed with cancer undergoing treatment with chemotherapy

Author

Anna Barata, Aasha I. Hoogland, Brent J. Small, Karina I. Acevedo, Michael H. Antoni, Brian D. Gonzalez, Paul B. Jacobsen, Suzanne C. Lechner, Dinorah Martinez Tyson, Cathy D. Meade, Yvelise Rodriguez, John M. Salsman, Allen C. Sherman, Steven K. Sutton, and Heather S. L. Jim

Subjects
Psychiatry and Mental health, Oncology, Neoplasms, Adaptation, Psychological, Quality of Life, Humans, Female, Spirituality, Experimental and Cognitive Psychology, Hispanic or Latino
Abstract

Previous studies have examined whether spiritual well-being is associated with cancer outcomes, but minority populations are under-represented. This study examines associations of baseline spiritual well-being and change in spiritual well-being with change in distress and quality of life, and explores potential factors associated with changes in spiritual well-being among Hispanic women undergoing chemotherapy.Participants completed measures examining spiritual well-being, distress, and quality of life prior to beginning chemotherapy and at weeks 7 and 13. Participants' acculturation and sociodemographic data were collected prior to treatment. Mixed models were used to examine the association of baseline spiritual well-being and change in spiritual well-being during treatment with change in distress and quality of life, and to explore whether sociodemographic factors, acculturation and clinical variables were associated with change in spiritual well-being.A total of 242 participants provided data. Greater baseline spiritual well-being was associated with less concurrent distress and better quality of life (p lt; 0.001), as well as with greater emotional and functional well-being over time (p values lt; 0.01). Increases in spiritual well-being were associated with improved social well-being during treatment, whereas decreases in spiritual well-being were associated with worsened social well-being (p lt; 0.01). Married participants reported greater spiritual well-being at baseline relative to non-married participants (p lt; 0.001).Greater spiritual well-being is associated with less concurrent distress and better quality of life, as well as with greater emotional, functional, and social well-being over time among Hispanic women undergoing chemotherapy. Future work could include developing culturally targeted spiritual interventions to improve survivors' well-being.

Published
2022

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