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244 results on '"Keklik, Muzaffer"'

10. Fludarabine-induced bradycardia in allogeneic hematopoietic stem cell transplantation: A retrospective study.

Author

Çelik, Serhat, Güven, Zeynep Tuğba, Altınsoy, Abdullah, Tubay, Şaziye Esra, Keklik, Muzaffer, and Ünal, Ali

Subjects
CELL transplantation, HEMATOPOIETIC stem cell transplantation, HOMOGRAFTS, RETROSPECTIVE studies, TREATMENT duration, MULTIVARIATE analysis, BRADYCARDIA, ODDS ratio, HEART beat, STATISTICS, HEALTH promotion, CONFIDENCE intervals, FLUDARABINE, OVERALL survival
Abstract

Introduction: Fludarabine, a purine analog, is getting more attention with the increasing use of reduced intensive conditioning regimens in allogeneic hematopoietic stem cell transplantation (allo-HSCT). The side effect of bradycardia was observed in only a few cases reported in the literature. In clinical practice, bradycardia can be asymptomatic or cause syncope and cardiac arrest. This study aimed to evaluate the bradycardia side effect of fludarabine used in the conditioning regimen in allo-HSCT recipients and to increase awareness of this issue. Methods: This retrospective study included 73 patients who received fludarabine in the allo-HSCT conditioning regimen between January 2015 and January 2021. Patients with and without bradycardia were compared regarding demographic data, allo-HSCT characteristics, electrolyte values, fludarabine administration dose and duration, and survival. Univariate and multivariate analyzes were performed to evaluate independent predictors for fludarabine-induced bradycardia. Results: Fludarabine administration doses and days were higher in the bradycardia group, but no statistically significant difference was observed. In the multivariate analysis, age was the only independent predictor of fludarabine-induced bradycardia (odds ratio (OR) 0.93, 95% confidence interval (CI): 0.89–0.98, p = 0.007). The median age in the group with bradycardia was 19 years younger than those without bradycardia (34 (19–49) vs 53 (19–69), p = 0.005). In 11 (84.6%) of the patients who had bradycardia, bradycardia improved with the discontinuation of fludarabine alone, but atropine was administered in 2 (15.4%) patients. Conclusion: Age was the only independent predictor of fludarabine-induced bradycardia; therefore, close heart rate monitoring is recommended during fludarabine administration, especially in younger patients. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Epidemiology and Prognosis of Sepsis in Cancer Patients: A Multicenter Prospective Observational Study

Author

Ture, Zeynep, primary, İskender, Gülşen, additional, Şahinoğlu, Mustafa Sehat, additional, Özkara, Ezel Beste, additional, Kalem, Ayşe Kaya, additional, EryılmazEren, Esma, additional, Ürkmez, Fatma Yekta, additional, Çetin, Sinan, additional, Azak, Emel, additional, Erdem, İlknur, additional, Rello, Jordi, additional, Alp, Emine, additional, Ulusoy, Ayten Merve, additional, Kayaaslan, Bircan, additional, Çubuk, Devrim, additional, Yıldızhan, Esra, additional, Özet, Gülsüm, additional, Özbaş, Hasan Mücahit, additional, Keklik, Muzaffer, additional, Mehtap, Özgür, additional, Akpınar, Seval, additional, Dağdaş, Simten, additional, Akar, Şebnem Şenol, additional, İriağaç, Yakup, additional, and Bulut, Tuğba, additional

Published
2024
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12. Clinical characteristics and therapeutic outcomes of paroxysmal nocturnal hemoglobinuria patients in Turkey: a multicenter experience

Author

Goren Sahin, Deniz, Akay, Olga Meltem, Keklik, Muzaffer, Okan, Vahap, Karakus, Abdullah, Demir, Cengiz, Erkurt, Mehmet Ali, Ilkkilic, Kadir, Yildirim, Rahsan, Akgun Cagliyan, Gulsum, Aksu, Salih, Dogu, Mehmet Hilmi, Dal, Mehmet Sinan, Karakus, Volkan, Gemici, Ali Ihsan, Terzi, Hatice, Kelkitli, Engin, Sivgin, Serdar, Unal, Ali, Yilmaz, Mehmet, Ayyildiz, Orhan, Korkmaz, Serdal, Eser, Bulent, and Altuntas, Fevzi

Published
2021
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14. Role of Uric Acid Levels as a Prognostic Indicator in Allogeneic Hematopoietic Stem Cell Transplantation: Insights from a Single-Center Study.

Author

Şanlı, Neslihan Mandacı, Keklik, Muzaffer, and Ünal, Ali

Subjects
*HEMATOPOIETIC stem cell transplantation, *URIC acid, *OVERALL survival, *PROGRESSION-free survival, *BLOOD diseases
Abstract

Uric acid (UA) acts as a richly available water-soluble antioxidant, contributing to approximately two-thirds of the overall free-radical-scavenging activity in human serum. It is discharged from damaged cells during the preparation for allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study assessed how pretransplantation uric acid levels influence survival and mortality in allo-HSCT patients. In a retrospective analysis of 267 patients with hematologic diseases who underwent allo-HSCT, uric acid levels were documented on the day of allo-HSCT (day 0). Patients were divided into two cohorts based on their pretransplant uric acid levels: those at or below 4.4 mg/dL and those above 4.4 mg/dL. Among them, 153 (57.3%) were male, and 114 (42.7%) were female, with a median age of 31 years (ranging from 13 to 66). Those with serum uric acid levels of 4.4 mg/dL or lower exhibited notably poorer overall survival (OS) and disease-free survival (DFS) compared to those surpassing 4.4 mg/dL (p=0.032 and p=0.045, respectively). Our findings indicate an interrelation between low pretransplant serum uric acid levels and reduced survival rates in allo-HSCT patients. Further exploration into potential mechanisms, such as compromised antioxidative capacity in hypouricemia, may establish uric acid as a promising prognostic marker in allo-HSCT. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Glofitamab in relapsed/refractory diffuse large B‐cell lymphoma: Real‐world data

Author

Birtas Atesoglu, Elif, primary, Gulbas, Zafer, additional, Uzay, Ant, additional, Ozcan, Muhit, additional, Ozkalemkas, Fahir, additional, Dal, Mehmet Sinan, additional, Kalyon, Hakan, additional, Akay, Olga Meltem, additional, Deveci, Burak, additional, Bekoz, Huseyin, additional, Sevindik, Omur Gokmen, additional, Toptas, Tayfur, additional, Yilmaz, Fergun, additional, Koyun, Derya, additional, Alkis, Nihan, additional, Alacacioglu, Inci, additional, Sonmez, Mehmet, additional, Yavasoglu, Irfan, additional, Tombak, Anil, additional, Mehtap, Ozgur, additional, Kurnaz, Fatih, additional, Yuce, Orhan Kemal, additional, Karakus, Volkan, additional, Turgut, Mehmet, additional, Kurekci, Derya Deniz, additional, Ayer, Mesut, additional, Keklik, Muzaffer, additional, Buyuktas, Deram, additional, Ozbalak, Murat, additional, and Ferhanoglu, Burhan, additional

Published
2023
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31. Retrospective Analysis of Turkish AML Registry Database, on Behalf of AML Working Group of Turkish Society of Hematology

Author

Karakuş, Volkan, primary, Sevindik, Omur Gokmen, additional, Karatas, Aylin, additional, Yenihayat, Emel Merve, additional, Polat, Merve Gokcen, additional, Çelik, Serhat, additional, Pinar, Ibrahim Ethem, additional, Dogan, Ali, additional, İnce, Idris, additional, Malkan, Umit Yavuz, additional, Iltar, Utku, additional, Ozdalcı, Demircan Özdalcı, additional, Mehtap, Özgür, additional, Erdem, Ramazan, additional, Kacmaz, Murat, additional, Aykas, Fatma, additional, Ozturk, Berna, additional, Deveci, Burak, additional, Akdeniz, Aydan, additional, Bulbul, Hale, additional, Yigit Kaya, Sureyya, additional, Can, Ferda, additional, Guven, Zeynep, additional, Aslan, Ceyda, additional, Keklik, Muzaffer, additional, Ozkalemkas, Fahir, additional, Goker, Hakan, additional, and Alacacıoğlu, İnci, additional

Published
2022
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50. Clofarabine, cyclophosphamide, and etoposide (CLOVE) in adult patients with relapsed/refractory acute T-cell lymphoblastic leukemia: single-center experience.

Author

Güven, Zeynep Tuğba, Tubay, Şaziye Esra, Çelik, Serhat, Keklik, Muzaffer, and Ünal, Ali

Subjects
LYMPHOBLASTIC leukemia, STEM cell transplantation, T cells, ACUTE leukemia, CYCLOPHOSPHAMIDE
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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