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3. Pilot Feasibility Study: 18F-DPA-714 PET/CT Macrophage Imaging in Triple-Negative Breast Cancers (EITHICS).

Author

Rousseau, Caroline, Metz, Raphaël, Kerdraon, Olivier, Ouldamer, Lobna, Boiffard, Florence, Renaudeau, Karine, Ferrer, Ludovic, Vercouillie, Johnny, Doutriaux-Dumoulin, Isabelle, Mouton, Alexis, Le Thiec, Maelle, Morel, Agnès, Rusu, Daniela, Santiago-Ribeiro, Maria-Joao, Campion, Loïc, Arlicot, Nicolas, and Kraeber-Bodéré, Françoise

Published
2024
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5. The inhibitory receptor CD94/NKG2A on CD8+ tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression

Author

Eugène, Juliette, Jouand, Nicolas, Ducoin, Kathleen, Dansette, Delphine, Oger, Romain, Deleine, Cécile, Leveque, Edouard, Meurette, Guillaume, Podevin, Juliette, Matysiak, Tamara, Bennouna, Jaafar, Bezieau, Stéphane, Volteau, Christelle, Thomas, Wassila El Alami, Chetritt, Jerôme, Kerdraon, Olivier, Fourquier, Pierre, Thibaudeau, Emilie, Dumont, Frédéric, Mosnier, Jean-François, Toquet, Claire, Jarry, Anne, Gervois, Nadine, and Bossard, Céline

Published
2020
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6. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Author

Lohard, Steven, Bourgeois, Nathalie, Maillet, Laurent, Gautier, Fabien, Fétiveau, Aurélie, Lasla, Hamza, Nguyen, Frédérique, Vuillier, Céline, Dumont, Alison, Moreau-Aubry, Agnès, Frapin, Morgane, David, Laurent, Loussouarn, Delphine, Kerdraon, Olivier, Campone, Mario, Jézéquel, Pascal, Juin, Philippe P., and Barillé-Nion, Sophie

Published
2020
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12. Pilot study with [18F]DPA-714 PET-CT to explore tumor-associated-macrophages in triple negative breast cancer.

Author

Rousseau, Caroline, primary, Arlicot, Nicolas, additional, Campion, Loic, additional, Kerdraon, Olivier, additional, Ferrer, Ludovic, additional, Vercouillie, Johnny, additional, Ouldamer, Lobna, additional, Doutriaux-Dumoulin, Isabelle, additional, Boiffard, Florence, additional, Renaudeau, Céline, additional, Mouton, Alexis, additional, Chalon, Sylvie, additional, Gulhan, Zuhal, additional, Fleury, Vincent, additional, Le Thiec, Maelle, additional, Maucherat, Bruno, additional, Rusu, Daniela, additional, Allam, Nadia, additional, Santiago-Ribeiro, Maria-Joao, additional, and Kraeber-Bodere, Francoise, additional

Published
2022
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17. Centre de Ressources Biologiques-Tumorothèque: Bioresources and Associated Clinical Data Dedicated to Translational Research in Oncology at the Institut de Cancérologie de l’Ouest, France

Author

Heymann, Dominique, primary, Kerdraon, Olivier, additional, Verriele, Véronique, additional, Verhille, Estelle, additional, Veron, Vanessa, additional, Vitre, Marie, additional, Delmas, Florian, additional, Henry, Cécile, additional, Gouy, Yann, additional, Amiand, Marie, additional, and Bard, Jean-Marie, additional

Published
2020
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18. Additional file 18: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

External TNBC cohort’s clinicopathologic characteristics in function of the three clusters (C’1, C’2, and C’3). (PDF 136 kb)

Published
2019
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19. Additional file 29: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Proposed therapeutic strategies in function of GES and robust subtyping results. (PDF 162 kb)

Published
2019
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20. Additional file 5: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Fuzzy clustering of 238 TNBC. Distribution of patients based on probability of belonging to cluster: C1, n = 55 (blue); C2, n = 98 (red) and C3, n = 85 (green). Each vertex of the triangle represents a cluster and each point represents a patient, placed as the barycenter of the triangle, weights being the probabilities of belonging to each of the clusters. The closer a point is to one of the vertices, the greater is the probability of the patient to belong to the corresponding cluster. (PDF 86 kb)

Published
2019
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21. Additional file 3: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Details of antibodies used for immunohistochemistry. (PDF 84 kb)

Published
2019
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22. Additional file 4: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohorts in the first PCA plane. (A) PACS08 patients (n = 131, [orange]) compared to TNBC patients of a previous study (n = 107, [black]). (B) Each color represents a recruitment site, except for grayish pale green color, which represents one or two patients recruited in different sites (n = 36 patients; 28 sites). Total number of recruitment sites was equal to 45. (PDF 95 kb)

Published
2019
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23. Additional file 9: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Categorical GES analyses result in function of internal TNBC clusters (C1, C2, and C3). (PDF 107 kb)

Published
2019
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24. Additional file 6: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Event-free survival analysis of TNBC pooled cohort. This cohort is composed of 427 patients from internal (n = 238) and external (n = 189) cohorts (C1 & C’1 [blue]; C2 & C’2 [red] and C3 & C’3 [green]). (PDF 141 kb)

Published
2019
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25. Additional file 7: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohort in the first PCA plane. (C1, n = 55 [blue]; C2, n = 98 [red]; C3, n = 85 [green]). (PDF 88 kb)

Published
2019
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26. Additional file 8: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

PCA of internal TNBC cohort. Lists of PC1 and PC2 twenty highest absolute weight probes. (PDF 115 kb)

Published
2019
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27. Molecular apocrine tumours in EORTC 10994/BIG 1-00 phase III study: pathological response after neoadjuvant chemotherapy and clinical outcomes

Author

Bonnefoi, Herve, MacGrogan, Gaetan, Poncet, C., Iggo, Richard, Pommeret, Fanny, Grellety, Thomas, Larsimont, Denis, Becette, Véronique, Kerdraon, Olivier, Bibeau, Frédéric, Ghnassia, Jean Pierre, Picquenot, Jean Michel, Thomas, Jeremy, Tille, Jean Christophe, Slaets, Leen, Bodmer, Alexandre, Bergh, Jonas, Cameron, David A, Bonnefoi, Herve, MacGrogan, Gaetan, Poncet, C., Iggo, Richard, Pommeret, Fanny, Grellety, Thomas, Larsimont, Denis, Becette, Véronique, Kerdraon, Olivier, Bibeau, Frédéric, Ghnassia, Jean Pierre, Picquenot, Jean Michel, Thomas, Jeremy, Tille, Jean Christophe, Slaets, Leen, Bodmer, Alexandre, Bergh, Jonas, and Cameron, David A

Abstract

Background: We explored, within the EORTC10994 study, the outcomes for patients with molecular apocrine (MA) breast cancer, and defined immunohistochemistry (IHC) as androgen-receptor (AR) positive, oestrogen (ER) and progesterone (PR) negative. We also assessed the concordance between IHC and gene expression arrays (GEA) in the identification of MA cancers. Methods: Centrally assessed biopsies for AR, ER, PR, HER2 and Ki67 by IHC were classified into six subtypes: MA, triple-negative (TN) basal-like, luminal A, luminal B HER2 negative, luminal B HER2 positive and “other”. The two main objectives were the pCR rates and survival outcomes in the overall MA subtype (and further divided by HER2 status) and the remaining five subtypes. Results: IHC subtyping was obtained in 846 eligible patients. Ninety-three (11%) tumours were classified as the MA subtype. Both IHC and GEA data were available for 64 patients. In this subset, IHC concordance was 88.3% in identifying MA tumours compared with GEA. Within the MA subtype, pCR was observed in 33.3% of the patients (95% CI: 29.4–43.9) and the 5-year recurrence-free interval was 59.2% (95% CI: 48.2–68.6). Patients with MA and TN basal-like tumours have lower survival outcomes. Conclusions: Irrespective of their HER2 status, the prognosis for MA tumours remains poor and adjuvant trials evaluating anti-androgens should be considered., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

28. Significance of lymph node involvement in local recurrence of colorectal cancer

Author

Dumont, Frédéric, primary, Muñoz, Miguel A., additional, Franco, Valéria, additional, Wernert, Romuald, additional, Verriele, Valérie, additional, Heyman, Marie‐Françoise, additional, Kerdraon, Olivier, additional, Capitain, Olivier, additional, Guerin‐Meyer, Véronique, additional, Raimbourg, Judith, additional, Senellart, Hélène, additional, Hiret, Sandrine, additional, Raoul, Jean‐Luc, additional, and Thibaudeau, Emilie, additional

Published
2019
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29. The inhibitory receptor CD94/NKG2A on CD8+ tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression.

Author

Eugène, Juliette, Jouand, Nicolas, Ducoin, Kathleen, Dansette, Delphine, Oger, Romain, Deleine, Cécile, Leveque, Edouard, Meurette, Guillaume, Podevin, Juliette, Matysiak, Tamara, Bennouna, Jaafar, Bezieau, Stéphane, Volteau, Christelle, Thomas, Wassila El Alami, Chetritt, Jerôme, Kerdraon, Olivier, Fourquier, Pierre, Thibaudeau, Emilie, Dumont, Frédéric, and Mosnier, Jean-François

Published
2020
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30. Abstract LB-142: CD94/NKG2A+ tumor-infiltrating lymphocytes in a context of HLA-E overexpression could be a promising new druggable inhibitory immune checkpoint in colorectal adenocarcinomas

Author

EUGENE, Juliette, primary, JOUAND, Nicolas, additional, DANSETTE, Delphine, additional, MEURETTE, Guillaume, additional, Podevin, Juliette, additional, MATYSIAK, Tamara, additional, BEZIEAU, Stephane, additional, VOLTEAU, Christelle, additional, THOMAS, Wassila EL ALAMI, additional, CHETRITT, Jerome, additional, KERDRAON, Olivier, additional, Fourquier, Pierre, additional, THIBAUDEAU, Emilie, additional, DUMONT, Frederic, additional, MOSNIER, Jean-Francois, additional, TOQUET, Claire, additional, JARRY, Anne, additional, GERVOIS, Nadine, additional, and Bossard, Celine, additional

Published
2018
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31. Intraepithelial CD94+ tumor-infiltrating lymphocytes in a context of HLA-E overexpression as a new immune checkpoint to predict prognosis in colorectal carcinomas.

Author

Bossard, Celine, primary, Eugene, Juliette, additional, Jouand, Nicolas, additional, Dansette, Delphine, additional, Leveque, Edouard, additional, Podevin, Juliette, additional, Matysiak, Tamara, additional, Bezieau, Stephane, additional, Chetritt, Jerome, additional, Kerdraon, Olivier, additional, Fourquier, Pierre, additional, Thibaudeau, Emilie, additional, Mosnier, Jean-François, additional, Jarry, Anne, additional, and Gervois, Nadine, additional

Published
2017
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33. Scattering matrices in the sl(3) twisted Yangian

Author

Kerdraon, Olivier, Doikou, Anastasia, Karaiskos, Nikos, Laboratoire de Physique Théorique et Modélisation (LPTM - UMR 8089), Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Laboratoire de Physique Théorique et Hautes Energies (LPTHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Engineering, University of Patras, and University of Patras [Patras]

Subjects
High Energy Physics - Theory, [PHYS]Physics [physics], Nonlinear Sciences::Exactly Solvable and Integrable Systems, High Energy Physics - Theory (hep-th), Nonlinear Sciences - Exactly Solvable and Integrable Systems, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], FOS: Physical sciences, Mathematical Physics (math-ph), Exactly Solvable and Integrable Systems (nlin.SI), Mathematical Physics
Abstract

A quantum spin chain with non-conventional boundary conditions is studied. The distinct nature of these boundary conditions arises from the conversion of a soliton to an anti-soliton after being reflected to the boundary, hence the appellation soliton non-preserving boundary conditions. We focus on the simplest non-trivial case of this class of models based on the twisted Yangian quadratic algebra. Our computations are performed through the Bethe ansatz equations in the thermodynamic limit. We formulate a suitable quantization condition describing the scattering process and proceed with explicitly determining the bulk and boundary scattering amplitudes. The energy and quantum numbers of the low lying excitations are also derived., 14 pages, Latex. A few comments added. Version to appear in JSTAT

Published
2015
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34. The inhibitory receptor CD94/NKG2A on CD8+tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression

Author

Eugène, Juliette, Jouand, Nicolas, Ducoin, Kathleen, Dansette, Delphine, Oger, Romain, Deleine, Cécile, Leveque, Edouard, Meurette, Guillaume, Podevin, Juliette, Matysiak, Tamara, Bennouna, Jaafar, Bezieau, Stéphane, Volteau, Christelle, Thomas, Wassila El Alami, Chetritt, Jerôme, Kerdraon, Olivier, Fourquier, Pierre, Thibaudeau, Emilie, Dumont, Frédéric, Mosnier, Jean-François, Toquet, Claire, Jarry, Anne, Gervois, Nadine, and Bossard, Céline

Abstract

We previously demonstrated that HLA-E/β2m overexpression by tumor cells in colorectal cancers is associated with an unfavorable prognosis. However, the expression of its specific receptor CD94/NKG2 by intraepithelial tumor-infiltrating lymphocytes, their exact phenotype and function, as well as the relation with the molecular status of colorectal cancer and prognosis remain unknown. Based on a retrospective cohort of 234 colorectal cancer patients, we assessed the expression of HLA-E, β2m, CD94, CD8, and NKp46 by immunohistochemistry on tissue microarray. The expression profile of HLA-E/β2m on tumor cells and the density of tumor-infiltrating lymphocytes were correlated to the clinicopathological and molecular features (Microsatellite status, BRAFand RASmutations). Then, from the primary tumors of 27 prospective colorectal cancers, we characterized by multiparameter flow cytometry the nature (T and/or NK cells) and the co-expression of the inhibitory NKG2A or activating NKG2C chain of ex vivo isolated CD94+tumor-infiltrating lymphocytes. Their biological function was determined using an in vitro redirected cytolytic activity assay. Our results showed that HLA-E/β2m was preferentially overexpressed in microsatellite instable tumors compared with microsatellite stable ones (45% vs. 19%, respectively, p= 0.0001), irrespective of the RASor BRAFmutational status. However, HLA-E/β2m+colorectal cancers were significantly enriched in CD94+intraepithelial tumor-infiltrating lymphocytes in microsatellite instable as well as in microsatellite stable tumors. Those CD94+tumor-infiltrating lymphocytes mostly corresponded to CD8+αβ T cells, and  to a lesser extent to NK cells, and mainly co-expressed a functional inhibitory NKG2A chain. Finally, a high number of CD94+intraepithelial tumor-infiltrating lymphocytes in close contact with tumor cells was independently associated with a worse overall survival. In conclusion, these findings strongly suggest that HLA-E/β2m–CD94/NKG2A represents a new druggable inhibitory immune checkpoint, preferentially expressed in microsatellite instable tumors, but also in a subgroup of microsatellite stable tumors, leading to a new opportunity in colorectal cancer immunotherapies.

Published
2020
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35. Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF): benign breast tumors – short text

Author

Lavoué, Vincent, primary, Fritel, Xavier, additional, Antoine, Martine, additional, Beltjens, Françoise, additional, Bendifallah, Sofiane, additional, Boisserie-Lacroix, Martine, additional, Boulanger, Loic, additional, Canlorbe, Geoffroy, additional, Catteau-Jonard, Sophie, additional, Chabbert-Buffet, Nathalie, additional, Chamming's, Foucauld, additional, Chéreau, Elisabeth, additional, Chopier, Jocelyne, additional, Coutant, Charles, additional, Demetz, Julie, additional, Guilhen, Nicolas, additional, Fauvet, Raffaele, additional, Kerdraon, Olivier, additional, Laas, Enora, additional, Legendre, Guillaume, additional, Mathelin, Carole, additional, Nadeau, Cédric, additional, Naggara, Isabelle Thomassin, additional, Ngô, Charlotte, additional, Ouldamer, Lobna, additional, Rafii, Arash, additional, Roedlich, Marie-Noelle, additional, Seror, Jérémy, additional, Séror, Jean-Yves, additional, Touboul, Cyril, additional, Uzan, Catherine, additional, and Daraï, Emile, additional

Published
2016
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39. Fischer 344 Rat.

Author

Azaïs, Henri, Queniat, Gurvan, Bonner, Caroline, Kerdraon, Olivier, Tardivel, Meryem, Jetpisbayeva, Gulim, Frochot, Céline, Betrouni, Nacim, Collinet, Pierre, and Mordon, Serge

Published
2015
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40. Pilot Feasibility Study: 18 F-DPA-714 PET/CT Macrophage Imaging in Triple-Negative Breast Cancers (EITHICS).

Author

Rousseau C, Metz R, Kerdraon O, Ouldamer L, Boiffard F, Renaudeau K, Ferrer L, Vercouillie J, Doutriaux-Dumoulin I, Mouton A, Le Thiec M, Morel A, Rusu D, Santiago-Ribeiro MJ, Campion L, Arlicot N, and Kraeber-Bodéré F

Subjects
Humans, Pilot Projects, Middle Aged, Female, Adult, Macrophages metabolism, Aged, Receptors, GABA metabolism, Triple Negative Breast Neoplasms diagnostic imaging, Pyrazoles, Pyrimidines, Positron Emission Tomography Computed Tomography, Feasibility Studies
Abstract

Abstract: Tumor-associated macrophages are targets of interest in triple-negative breast cancer (TNBC). The translocator protein 18 kDa (TSPO) is a sensitive marker for macrophages and holds potential relevance in TNBC stratification. This pilot prospective study (EITHICS, NCT04320030) aimed to assess the potential of TSPO PET/CT imaging using 18 F-DPA-714 in primary TNBC, compared with immunohistochemistry, autoradiography, and TSPO polymorphism., Patients and Methods: Thirteen TNBC patients were included. They underwent TSPO genotyping (HAB, MAB, LAB), 18 F-FDG PET/CT, and breast MRI. Semiquantitative PET parameters were computed. VOIs were defined on the tumor lesion, healthy breast tissue, and pectoral muscle to obtain SUV, tumor-to-background ratio (TBR), and time-activity curves (TACs). Additionally, immunohistochemistry, 3 H-DPA-714, and 3 H-PK-11195 autoradiography were conducted., Results: The majority of TNBC tumors (11/13, 84%) had a preponderance of M2-polarized macrophages with a median proportion of 82% (range, 44%-94%). 18 F-DPA-714 PET/CT clearly identified TNBC tumors with an excellent TBR. Three distinct patterns of 18 F-DPA-714 TACs were identified, categorized as "above muscular," "equal to muscular," and "below muscular" with reference to the muscular background. For the "above muscular" group (2 HAB and 2 MAB), "equal muscular" group (3 HAB, 3 MAB, and 1 LAB), and "below muscular" group (1 LAB and 1 MAB), tumor TACs showed a 18 F-DPA-714 accumulation slope of 1.35, 0.62, and 0.22, respectively, and a median SUV mean of 4.02 (2.09-5.31), 1.66 (0.93-3.07), and 0.61 (0.43-1.02)., Conclusions: This study successfully demonstrated TNBC tumor targeting by 18 F-DPA-714 with an excellent TBR, allowing to stratify 3 patterns of uptake potentially influenced by the TSPO polymorphism status. Further studies in larger populations should be performed to evaluate the prognostic value of this new biomarker., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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42. Molecular apocrine tumours in EORTC 10994/BIG 1-00 phase III study: pathological response after neoadjuvant chemotherapy and clinical outcomes.

Author

Bonnefoi H, MacGrogan G, Poncet C, Iggo R, Pommeret F, Grellety T, Larsimont D, Bécette V, Kerdraon O, Bibeau F, Ghnassia JP, Picquenot JM, Thomas J, Tille JC, Slaets L, Bodmer A, Bergh J, and Cameron D

Subjects
Breast Neoplasms genetics, Breast Neoplasms surgery, Chemotherapy, Adjuvant, Disease-Free Survival, ErbB Receptors metabolism, Female, Gene Expression Profiling, Humans, Immunohistochemistry, Receptor, ErbB-2 metabolism, Receptors, Androgen metabolism, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, Survival Rate, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms metabolism
Abstract

Background: We explored, within the EORTC10994 study, the outcomes for patients with molecular apocrine (MA) breast cancer, and defined immunohistochemistry (IHC) as androgen-receptor (AR) positive, oestrogen (ER) and progesterone (PR) negative. We also assessed the concordance between IHC and gene expression arrays (GEA) in the identification of MA cancers., Methods: Centrally assessed biopsies for AR, ER, PR, HER2 and Ki67 by IHC were classified into six subtypes: MA, triple-negative (TN) basal-like, luminal A, luminal B HER2 negative, luminal B HER2 positive and "other". The two main objectives were the pCR rates and survival outcomes in the overall MA subtype (and further divided by HER2 status) and the remaining five subtypes., Results: IHC subtyping was obtained in 846 eligible patients. Ninety-three (11%) tumours were classified as the MA subtype. Both IHC and GEA data were available for 64 patients. In this subset, IHC concordance was 88.3% in identifying MA tumours compared with GEA. Within the MA subtype, pCR was observed in 33.3% of the patients (95% CI: 29.4-43.9) and the 5-year recurrence-free interval was 59.2% (95% CI: 48.2-68.6). Patients with MA and TN basal-like tumours have lower survival outcomes., Conclusions: Irrespective of their HER2 status, the prognosis for MA tumours remains poor and adjuvant trials evaluating anti-androgens should be considered.

Published
2019
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43. Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF): benign breast tumors - short text.

Author

Lavoué V, Fritel X, Antoine M, Beltjens F, Bendifallah S, Boisserie-Lacroix M, Boulanger L, Canlorbe G, Catteau-Jonard S, Chabbert-Buffet N, Chamming's F, Chéreau E, Chopier J, Coutant C, Demetz J, Guilhen N, Fauvet R, Kerdraon O, Laas E, Legendre G, Mathelin C, Nadeau C, Naggara IT, Ngô C, Ouldamer L, Rafii A, Roedlich MN, Seror J, Séror JY, Touboul C, Uzan C, and Daraï E

Subjects
Biopsy, Breast Cyst diagnosis, Breast Cyst therapy, Breast Diseases diagnosis, Breast Neoplasms surgery, Calcinosis diagnosis, Calcinosis pathology, Female, France, Humans, Hyperplasia pathology, Hyperplasia surgery, Mammography, Mastitis therapy, Mastodynia therapy, Nipple Discharge diagnostic imaging, Phyllodes Tumor diagnosis, Phyllodes Tumor pathology, Phyllodes Tumor surgery, Ultrasonography, Mammary, Breast Neoplasms diagnosis, Breast Neoplasms therapy
Abstract

Screening with breast ultrasound in combination with mammography is needed to investigate a clinical breast mass (Grade B), colored single-pore breast nipple discharge (Grade C), or mastitis (Grade C). The BI-RADS system is recommended for describing and classifying abnormal breast imaging findings. For a breast abscess, a percutaneous biopsy is recommended in the case of a mass or persistent symptoms (Grade C). For mastalgia, when breast imaging is normal, no MRI or breast biopsy is recommended (Grade C). Percutaneous biopsy is recommended for a BI-RADS category 4-5 mass (Grade B). For persistent erythematous nipple or atypical eczema lesions, a nipple biopsy is recommended (Grade C). For distortion and asymmetry, a vacuum core-needle biopsy is recommended due to the risk of underestimation by simple core-needle biopsy (Grade C). For BI-RADS category 4-5 microcalcifications without any ultrasound signal, a minimum 11-G vacuum core-needle biopsy is recommended (Grade B). In the absence of microcalcifications on radiography cores additional samples are recommended (Grade B). For atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ, flat epithelial atypia, radial scar and mucocele with atypia, surgical excision is commonly recommended (Grade C). Expectant management is feasible after multidisciplinary consensus. For these lesions, when excision margins are not clear, no new excision is recommended except for LCIS characterized as pleomorphic or with necrosis (Grade C). For grade 1 phyllodes tumor, surgical resection with clear margins is recommended. For grade 2 phyllodes tumor, 10mm margins are recommended (Grade C). For papillary breast lesions without atypia, complete disappearance of the radiological signal is recommended (Grade C). For papillary breast lesions with atypia, complete surgical excision is recommended (Grade C)., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Published
2016
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