12 results on '"Khalif IL"'
Search Results
2. Long-term results of medical treatment in patients with a severe attack of ulcerative colitis
- Author
-
Nanaeva Ba, Khalif Il, A. O. Golovenko, and O. V. Golovenko
- Subjects
Adult ,Male ,History ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Azathioprine ,Maintenance therapy ,Recurrence ,Internal medicine ,Humans ,Medicine ,In patient ,Colectomy ,Medical treatment ,business.industry ,Age Factors ,General Medicine ,Middle Aged ,medicine.disease ,Ulcerative colitis ,Infliximab ,Treatment Outcome ,Acute Disease ,Prednisolone ,Colitis, Ulcerative ,Female ,Family Practice ,business ,Follow-Up Studies ,medicine.drug - Abstract
To assess the long-term result of medical treatment in patients with a severe attack (SA) of ulcerative colitis (UC).The course of UC was analyzed in 56 patients who were accessible by telephone contact and consecutively recruited for a year after therapy for a SA of UC. All the patients were stated to have a SA of UC according to the Truelove-Witts' criteria; they received therapy with intravenous glucocorticosteroids (GCS) (prednisolone 2 mg/kg) along with anti-recurrence therapy with mesalasine (5-ASA) or azathioprine (AZA). Ten (17.9%) GCS-resistant patients were given infliximab (INF) (5 mg/ kg), followed by its maintenance infusions. Anti-recurrence therapy using 5-ASA, AZA, and INF was performed in 33 (58.9%), 13 (23.2%), and 10 (17.9%) patients, respectively.During one year, 14 (25%) patients continued to be in clinical remission on maintenance therapy or to have attacks stopped without using GCS, immunosuppressive agents, or INF (a satisfactory response group). Colectomy was carried out in 23 (41.1%) patients; due to recurrent UC when decreasing the dose of GCS, 5 (8.9%) patients continued to take the latter during a year. A GCS cycle was repeated in 3 patients who had received AZA (the basic therapy was not corrected) and 11 patients who had taken 5-ASA. The prognostic factors for a long-term result of medical therapy included the choice of AZA as an anti-recurrent drug (57.1 and 11.9% in the satisfactory and poor treatment outcome groups, respectively; p = 0.004) and patient age (34.4 and 42.8 years, respectively; p = 0.0357).During 1 year after a SA of UC, indications for colectomy and repeated GCS use occurred in 41 and 34% of the patients, respectively. The long-term efficiency of medical therapy for a SA of UC declines with advancing age. The use of AZA as an anti-recurrence agent after termination of GCS intake increases the probability of long-term clinical response.Цель исследования. Оценить долгосрочный результат консервативного лечения больных с тяжелым обострением (ТО) язвенного колита (ЯК). Материалы и методы. Проанализировали течение ЯК у 56 доступных для телефонного контакта последовательно набранных пациентов в течение года после проведения терапии ТО ЯК. У всех пациентов констатировано ТО ЯК по критериям Truelove-Witts и проведена терапия внутривенными глюкокортикостероидами - ГКС (преднизолон 2 мг/кг) с назначением противорецидивной терапии месалазином (5-АСК) или азатиоприном (АЗА). Резистентным к ГКС 10 (17,9%) пациентам назначен инфликсимаб - ИНФ (5 мг/кг) с проведением последующих поддерживающих инфузий. Противорецидивную терапию проводили 33 (58,9%) пациентам 5-АСК, 13 (23,2%) АЗА, 10 (17,9%) ИНФ. Результаты. В течение 1 года у 14 (25%) больных сохранялась клиническая ремиссия на фоне поддерживающей терапии или отмечались обострения, купированные без применения ГКС, иммуносупрессоров или ИНФ (группа с удовлетворительным ответом). Колэктомия выполнена 23 (41,1%) больным, 5 (8,9%) пациентов в связи с рецидивом ЯК при снижении дозы ГКС продолжили прием ГКС в течение 1 года. Повторный курс ГКС проведен 3 пациентам, получавшим АЗА (базисная терапия не корректировалась), и 11 больным, получавшим 5-АСК. К прогностическим факторам долгосрочного результата консервативной терапии отнесены выбор АЗА в качестве противорецидивного препарата (57,1 и 11,9% в группах с удовлетворительным и неудовлетворительным исходом лечения соответственно; р=0,004) и возраст больных (34,4 и 42,8 года соответственно; р=0,0357). Заключение. В течение 1 года после ТО ЯК у 41% больных возникают показания к колэктомии, у 34% - к повторному применению ГКС. Долгосрочная эффективность консервативной терапии ТО ЯК уменьшается с увеличением возраста. Применение АЗА в качестве противорецидивного средства после окончания приема ГКС повышает вероятность долгосрочного клинического ответа.
- Published
- 2015
3. [Irritable bowel syndrome in the Russian Federation: results of the ROMERUS multicenter observational study].
- Author
-
Maev IV, Okhlobystina OZ, Khalif IL, and Andreev DN
- Subjects
- Humans, Male, Female, Adult, Quality of Life, Constipation, Diarrhea diagnosis, Abdominal Pain diagnosis, Abdominal Pain epidemiology, Abdominal Pain etiology, Surveys and Questionnaires, Russia epidemiology, Irritable Bowel Syndrome diagnosis, Irritable Bowel Syndrome epidemiology, Irritable Bowel Syndrome complications
- Abstract
Background: Irritable bowel syndrome (IBS) is one of the most common functional disorders of the gastrointestinal tract. According to Russian guidelines, a standard examination using laboratory and instrumental evaluation methods, including colonoscopy, should be performed to establish the diagnosis of IBS., Aim: To characterize the Russian population of IBS patients., Materials and Methods: A multicenter observational prospective study ROMERUS was conducted at 35 clinical centers in the Russian Federation. The study included male and female patients aged 18 to 50 with a diagnosis of IBS based on the Rome IV criteria, with no signs of structural gastrointestinal disease. The follow-up duration was 6 months and included three patients' visits to the study site. During the study, data were collected on patients' demographic and clinical characteristics, medical history, and drug therapy. The secondary parameters included the assessment of the proportion of patients with a diagnosis of IBS confirmed by a standard examination among all patients meeting the Rome IV criteria, the evaluation of the change over time of the IBS symptoms, quality of life (QoL), and adherence to therapy. Characterization of the population was performed using descriptive statistics methods. The standard examination results were presented as the percentage of patients with IBS confirmed by the standard examination among all patients meeting the Rome IV criteria, with a two-sided 95% confidence interval., Results: The study included 1004 patients with a diagnosis of IBS according to the Rome IV criteria, with 790 (78.7%) patients included in the final analysis. The mean age of patients was 34.0±7.5 years; they were predominantly female (70.4%), Caucasian (99.4%), married (55.1%), urban residents (97.5%) with higher education (64.5%) and a permanent position (74.9%). Patients enrolled in the study have low physical activity and lack a healthy diet. The smoking rate was 26.3%. IBS symptoms with predominant constipation (IBS-C) were observed in 28.1% of patients; 28.9% had IBS with predominant diarrhea (IBS-D), 11.9% had mixed-type IBS, and 31.1% had non-classified IBS. The main IBS symptoms were pain (99.7%), abdominal distension (71.1%), and fullness (36.8%). Biliary tract dysfunction (18.9%) and gastritis (17.2%) were the most frequently reported comorbidities. Prior to enrollment, 28% of patients received drug therapy. The most commonly prescribed drug during the study was mebeverine (54.1%). At 6 months of follow-up, there was a significant reduction of abdominal pain, bloating, and distention, and a twofold reduction in the incidence of constipation and diarrhea in the subgroups of patients with IBS-C and IBS-D, respectively. The overall QoL score measured by the IBS-QoL questionnaire increased from 83.0 to 95.2 points ( p <0.05) during the study. In the overall assessment of their condition, 69.6% of patients noted no symptoms and 25.3% reported marked improvement, 35% were asymptomatic according to the physician's overall assessment of the patient's condition, and 51.8% showed significant improvement., Conclusion: IBS patients in the Russian Federation were characterized. The diagnosis of IBS, established following the Rome IV criteria, is confirmed by the results of a standard examination in 96.3% of patients. The Rome IV criteria for the IBS diagnosis make it possible to establish a diagnosis with a probability of 94.7%. For 6 months of follow-up, there was a clinical improvement with a decrease in the severity of symptoms and a QoL improvement.
- Published
- 2023
- Full Text
- View/download PDF
4. Multiple Cytokine Profiling: A New Model to Predict Response to Tumor Necrosis Factor Antagonists in Ulcerative Colitis Patients.
- Author
-
Obraztsov IV, Shirokikh KE, Obraztsova OI, Shapina MV, Wang MH, and Khalif IL
- Subjects
- Adult, Colitis, Ulcerative drug therapy, Female, Follow-Up Studies, Humans, Male, Prognosis, Biomarkers blood, Colitis, Ulcerative blood, Cytokines blood, Infliximab therapeutic use, Tumor Necrosis Factor Inhibitors therapeutic use, Tumor Necrosis Factor-alpha antagonists & inhibitors
- Abstract
Background and Aims: Ulcerative colitis (UC) is a form of inflammatory bowel disease, and antibodies against tumor necrosis factor (anti-TNF) are used for treatment. Many patients are refractory or lose response to anti-TNF, and predicting response would be an extremely valuable clinical tool. Unlike most biomarkers, cytokines directly mediate inflammation, and their measurement may predict the likelihood of response or no response., Methods: Serum samples were obtained from 49 UC patients before infliximab infusions, and levels of 17 cytokines were measured using a multiplex assay. The Fisher linear discriminant analysis (FLDA) was applied to the cytokine values to predict which patients would respond to infliximab. "Response" was defined as clinical remission after the third infusion, and "no response" was defined as lack of remission after the third infusion., Results: The Fisher linear discriminant analysis model identified a subset of seven predictor cytokines: TNF-α, IL-12, IL-8, IL-2, IL-5, IL1-β, and IFN-γ. The obtained canonical coefficients enabled to calculate discriminant scores as linear combinations of the cytokines; model classified thepatients as responders and nonresponders with a sensitivity of 84.2% and a specificity of 93.3%. Overall, the yield of the FLDA model was 89.8% of the total 49 patients., Conclusions: An unbiased, statistically derived, predictive model based on measurement of serum cytokines before therapy may predict a positive or negative outcome from the administration of anti-TNF to UC patients. Because accurately measuring cytokines is simple and inexpensive, the model may be a valuable new tool to complement other laboratory parameters used in the management of IBD patients., (© 2018 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2019
- Full Text
- View/download PDF
5. Genetic diversity of Escherichia coli in gut microbiota of patients with Crohn's disease discovered using metagenomic and genomic analyses.
- Author
-
Tyakht AV, Manolov AI, Kanygina AV, Ischenko DS, Kovarsky BA, Popenko AS, Pavlenko AV, Elizarova AV, Rakitina DV, Baikova JP, Ladygina VG, Kostryukova ES, Karpova IY, Semashko TA, Larin AK, Grigoryeva TV, Sinyagina MN, Malanin SY, Shcherbakov PL, Kharitonova AY, Khalif IL, Shapina MV, Maev IV, Andreev DN, Belousova EA, Buzunova YM, Alexeev DG, and Govorun VM
- Subjects
- Cluster Analysis, Crohn Disease microbiology, Escherichia coli isolation & purification, Feces microbiology, Genome, Bacterial, Humans, Intestinal Mucosa microbiology, Crohn Disease pathology, Escherichia coli genetics, Gastrointestinal Microbiome, Genetic Variation, Metagenomics methods
- Abstract
Background: Crohn's disease is associated with gut dysbiosis. Independent studies have shown an increase in the abundance of certain bacterial species, particularly Escherichia coli with the adherent-invasive pathotype, in the gut. The role of these species in this disease needs to be elucidated., Methods: We performed a metagenomic study investigating the gut microbiota of patients with Crohn's disease. A metagenomic reconstruction of the consensus genome content of the species was used to assess the genetic variability., Results: The abnormal shifts in the microbial community structures in Crohn's disease were heterogeneous among the patients. The metagenomic data suggested the existence of multiple E. coli strains within individual patients. We discovered that the genetic diversity of the species was high and that only a few samples manifested similarity to the adherent-invasive varieties. The other species demonstrated genetic diversity comparable to that observed in the healthy subjects. Our results were supported by a comparison of the sequenced genomes of isolates from the same microbiota samples and a meta-analysis of published gut metagenomes., Conclusions: The genomic diversity of Crohn's disease-associated E. coli within and among the patients paves the way towards an understanding of the microbial mechanisms underlying the onset and progression of the Crohn's disease and the development of new strategies for the prevention and treatment of this disease.
- Published
- 2018
- Full Text
- View/download PDF
6. Certolizumab pegol in treatment of Crohn's disease with perianal lesions.
- Author
-
Khalif IL, Nanaeva BA, Shapina MV, and Vardanyan AV
- Subjects
- Humans, Immunoglobulin Fab Fragments, Polyethylene Glycols, Quality of Life, Treatment Outcome, Antibodies, Monoclonal, Humanized therapeutic use, Certolizumab Pegol therapeutic use, Crohn Disease drug therapy
- Abstract
Aim: To assess the effectiveness of conservative treatment of Crohn's disease (CD) with perianal lesions., Materials and Methods: The study included 20 patients with CD with perianal fistulae. Prior to the start of conservative therapy, 7 patients underwent fistulae drainage with setton placement. During the study, all patients received therapy with certolizumab pegol (CP) for a year. At the time of treatment initiation and after 12 months, the CD activity index, the quality of life according to IBDQ questionnaires and the perianal Crohn's disease activity index (PCDAI) were assessed., Results: After a year of CP therapy, clinical remission was achieved in 8 (40%) patients, endoscopic remission in 7 (35%) patients, fistula closure in 6 (30%) patients. There was also a decrease in the PCDAI with the average score 3.6 points compared to 9.3 points (p˂0.05) prior to the treatment. An improvement in the quality of life of patients was also established, the average quality of life index was 182,2 points compared to 156,0 points (p˂0.05) prior to the treatment., Conclusion: This study showed that CP therapy is effective in treatment of CD with perianal lesions.
- Published
- 2018
- Full Text
- View/download PDF
7. Genome analysis of E. coli isolated from Crohn's disease patients.
- Author
-
Rakitina DV, Manolov AI, Kanygina AV, Garushyants SK, Baikova JP, Alexeev DG, Ladygina VG, Kostryukova ES, Larin AK, Semashko TA, Karpova IY, Babenko VV, Ismagilova RK, Malanin SY, Gelfand MS, Ilina EN, Gorodnichev RB, Lisitsyna ES, Aleshkin GI, Scherbakov PL, Khalif IL, Shapina MV, Maev IV, Andreev DN, and Govorun VM
- Subjects
- Adult, Anti-Bacterial Agents pharmacology, Bacteriocins biosynthesis, Drug Resistance, Bacterial genetics, Escherichia coli drug effects, Escherichia coli metabolism, Female, Genetic Variation, Humans, Male, Middle Aged, Phylogeny, Young Adult, Crohn Disease microbiology, Escherichia coli genetics, Escherichia coli physiology, Genomics
- Abstract
Background: Escherichia coli (E. coli) has been increasingly implicated in the pathogenesis of Crohn's disease (CD). The phylogeny of E. coli isolated from Crohn's disease patients (CDEC) was controversial, and while genotyping results suggested heterogeneity, the sequenced strains of E. coli from CD patients were closely related., Results: We performed the shotgun genome sequencing of 28 E. coli isolates from ten CD patients and compared genomes from these isolates with already published genomes of CD strains and other pathogenic and non-pathogenic strains. CDEC was shown to belong to A, B1, B2 and D phylogenetic groups. The plasmid and several operons from the reference CD-associated E. coli strain LF82 were demonstrated to be more often present in CDEC genomes belonging to different phylogenetic groups than in genomes of commensal strains. The operons include carbon-source induced invasion GimA island, prophage I, iron uptake operons I and II, capsular assembly pathogenetic island IV and propanediol and galactitol utilization operons., Conclusions: Our findings suggest that CDEC are phylogenetically diverse. However, some strains isolated from independent sources possess highly similar chromosome or plasmids. Though no CD-specific genes or functional domains were present in all CD-associated strains, some genes and operons are more often found in the genomes of CDEC than in commensal E. coli. They are principally linked to gut colonization and utilization of propanediol and other sugar alcohols.
- Published
- 2017
- Full Text
- View/download PDF
8. Inflammatory bowel disease treatment in Eastern Europe: current status, challenges and needs.
- Author
-
Khalif IL and Shapina MV
- Subjects
- Disability Evaluation, Europe, Eastern epidemiology, Humans, Incidence, Inflammatory Bowel Diseases epidemiology, Needs Assessment, Patient Education as Topic, Prospective Studies, Health Services Accessibility standards, Inflammatory Bowel Diseases therapy, Practice Patterns, Physicians' statistics & numerical data, Quality Improvement standards, Quality of Health Care standards
- Abstract
Purpose of Review: To analyze the available studies of course, diagnosis and treatment of Inflammatory bowel disease (IBD) in Eastern Europe., Recent Findings: According to published data, full epidemiological studies were conducted only in Czech Republic, Estonia, Hungary and Romania. Russia was recently included in the EpiCom study, although only Moscow region data were provided., Summary: We summarize previously published and unpublished data on the epidemiology, IBD diagnosis and treatment in Eastern Europe. In addition, changes during several years are presented. These data show that IBD epidemiology in Eastern Europe corresponds to the previously known patterns, and that the quality of IBD health care has improved in the last several years.
- Published
- 2017
- Full Text
- View/download PDF
9. [All-Russian Consensus on Diagnosis and Treatment of Celiac Disease in Children and Adults].
- Author
-
Parfenov AI, Bykova SV, Sabel'nikova EA, Maev IV, Baranov AA, Bakulin IG, Krums LM, Bel'mer SV, Borovik TE, Zakharova IN, Dmitrieva YA, Roslavtseva EA, Kornienko EA, Khavkin AI, Potapov AS, Revnova MO, Mukhina YG, Shcherbakov PL, Fedorov ED, Belousova EA, Khalif IL, Khomeriki SG, Rotin DL, Vorob'eva NG, Pivnik AV, Gudkova RB, Chernin VV, Vokhmyanina NV, Pukhlikova TV, Degtyarev DA, Damulin IV, Mkrtumyan AM, Dzhulai GS, Tetruashvili NK, Baranovsky AY, Nazarenko LI, Kharitonov AG, Loranskaya ID, Saifutdinov RG, Livzan MA, Abramov DA, Osipenko MF, Oreshko LV, Tkachenko EI, Sitkin SI, and Efremov LI
- Subjects
- Adult, Child, Evidence-Based Medicine, Humans, Russia, Celiac Disease classification, Celiac Disease diagnosis, Celiac Disease therapy, Disease Management
- Abstract
The paper presents the All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults, which has been elaborated by leading experts, such as gastroenterologists and pediatricians of Russia on the basis of the existing Russian and international guidelines. The consensus approved at the 42nd Annual Scientific Session of the Central Research Institute of Gastroenterology on Principles of Evidence-Based Medicine into Clinical Practice (March 2-3, 2016). The consensus is intended for practitioners engaged in the management and treatment of patients with celiac disease. Evidence for the main provisions of the consensus was sought in electronic databases. In making recommendations, the main source was the publications included in the Cochrane Library, EMBASE, MEDLINE, and PubMed. The search depth was 10 years. Recommendations in the preliminary version were reviewed by independent experts. Voting was done by the Delphic polling system.
- Published
- 2017
- Full Text
- View/download PDF
10. CANCERPREVENTIVE IN ULCERATIVE COLITIS.
- Author
-
Podolskaya DV, Shapina MV, and Khalif IL
- Subjects
- Animals, Colitis, Ulcerative metabolism, Colitis, Ulcerative pathology, Colorectal Neoplasms metabolism, Colorectal Neoplasms pathology, Humans, Colitis, Ulcerative drug therapy, Colorectal Neoplasms prevention & control, Immunologic Factors therapeutic use, Mesalamine therapeutic use, Ursodeoxycholic Acid therapeutic use
- Abstract
Colorectal cancer (CRC) is an actual problem today And it occurs 6 times more frequently in patients with inflammatory bowel diseases (IBD) than in healthy population. CRC in IBD patients is more aggressive and needs total colectomy, which leads to permanent disability That is why canceroprevention is one of the key goals of IBD treatment. The aim of this review is to overview actual pathogenesis pathways of CRC in IBD and methods of chemoprevention. In this review we describe risk factors of CRC, which can be summarized as aggressive disease and chronic inflammation and are based on pathogenesis of CRC. That is the reason why methods of chemoprevention needs to influence on inflammation and other pathogenesis pathways. The role of such classes of medication as non-steroidal anti-inflammatory drugs, 5-aminosalicylic acid, immunomodulators, ursodeoxycholic acid in canceroprevention in RD patients are described in this review.
- Published
- 2016
11. [Long-term results of medical treatment in patients with a severe attack of ulcerative colitis].
- Author
-
Khalif IL, Nanaeva BA, Golovenko AO, and Golovenko OV
- Subjects
- Acute Disease, Adult, Age Factors, Female, Follow-Up Studies, Humans, Male, Middle Aged, Recurrence, Treatment Outcome, Colitis, Ulcerative drug therapy
- Abstract
Aim: To assess the long-term result of medical treatment in patients with a severe attack (SA) of ulcerative colitis (UC)., Subjects and Methods: The course of UC was analyzed in 56 patients who were accessible by telephone contact and consecutively recruited for a year after therapy for a SA of UC. All the patients were stated to have a SA of UC according to the Truelove-Witts' criteria; they received therapy with intravenous glucocorticosteroids (GCS) (prednisolone 2 mg/kg) along with anti-recurrence therapy with mesalasine (5-ASA) or azathioprine (AZA). Ten (17.9%) GCS-resistant patients were given infliximab (INF) (5 mg/ kg), followed by its maintenance infusions. Anti-recurrence therapy using 5-ASA, AZA, and INF was performed in 33 (58.9%), 13 (23.2%), and 10 (17.9%) patients, respectively., Results: During one year, 14 (25%) patients continued to be in clinical remission on maintenance therapy or to have attacks stopped without using GCS, immunosuppressive agents, or INF (a satisfactory response group). Colectomy was carried out in 23 (41.1%) patients; due to recurrent UC when decreasing the dose of GCS, 5 (8.9%) patients continued to take the latter during a year. A GCS cycle was repeated in 3 patients who had received AZA (the basic therapy was not corrected) and 11 patients who had taken 5-ASA. The prognostic factors for a long-term result of medical therapy included the choice of AZA as an anti-recurrent drug (57.1 and 11.9% in the satisfactory and poor treatment outcome groups, respectively; p = 0.004) and patient age (34.4 and 42.8 years, respectively; p = 0.0357)., Conclusion: During 1 year after a SA of UC, indications for colectomy and repeated GCS use occurred in 41 and 34% of the patients, respectively. The long-term efficiency of medical therapy for a SA of UC declines with advancing age. The use of AZA as an anti-recurrence agent after termination of GCS intake increases the probability of long-term clinical response.
- Published
- 2015
- Full Text
- View/download PDF
12. [Efficiency of tacrolimus therapy for perianal Crohn's disease].
- Author
-
Nanaeva BA, Vardanyan AV, and Khalif IL
- Subjects
- Adult, Anal Canal, Colitis diagnosis, Crohn Disease diagnosis, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Immunosuppressive Agents administration & dosage, Male, Middle Aged, Prospective Studies, Treatment Outcome, Young Adult, Colitis drug therapy, Crohn Disease drug therapy, Tacrolimus administration & dosage
- Abstract
Aim: To determine the efficacy of 0.1% tacrolimus ointment in patients with perianal Crohn's disease (CD)., Subjects and Methods: This prospective randomized trial enrolled 20 patients with perianal CD as anal fissures and rectal fistulas. The inclusion criteria were rectovaginal or extrasphincteric fistulas and purulent leakages. A study group comprised 11 patients, including 9 with anal fissures and 2 with fistulas. A control group included 9 patients, including 8 with fissures and 1 with fistulas. The study group received systemic therapy with azathioprine 2 mg/kg/day and tacrolimus ointment 2 mg/day; the control group had systemic therapy with azathioprine 2 mg/kg/day, hormone ointment 1 mg/day, and metronidazole suppositories 250 mg/day. Control examination and perianal CD activity index (PCDAI) determination were done 6 and 12 weeks after therapy initiation., Results: At 6 weeks after beginning the study, local examination revealed the signs of anal fissure epithelialization in 5 (45.5%) of the 11 patients in the study group and in 3 (33.3%) of the 9 patients in the control one. At 12 weeks, fissure epithelialization and fistula obliteration were stated in 6 (54%) patients in the study group and in 3 (33%) of the 9 patients in the control group. At 12 weeks, PCDAI in the study and control groups was 2.00 and 4.44 scores (p = 0.01)., Conclusion: The findings suggest that topical 0.1% tacrolimus ointment versus antibacterial suppositories and hormone ointments is effective in treating patients with perianal CD. Topical 0.1% tacrolimus ointment therapy caused a reduction in PCDAI.
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.