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2,242 results on '"Kim, Soo-Hyun"'

8. Cardiogenic control of affective behavioural state

Author

Hsueh, Brian, Chen, Ritchie, Jo, YoungJu, Tang, Daniel, Raffiee, Misha, Kim, Yoon Seok, Inoue, Masatoshi, Randles, Sawyer, Ramakrishnan, Charu, Patel, Sneha, Kim, Doo Kyung, Liu, Tony X, Kim, Soo Hyun, Tan, Longzhi, Mortazavi, Leili, Cordero, Arjay, Shi, Jenny, Zhao, Mingming, Ho, Theodore T, Crow, Ailey, Yoo, Ai-Chi Wang, Raja, Cephra, Evans, Kathryn, Bernstein, Daniel, Zeineh, Michael, Goubran, Maged, and Deisseroth, Karl

Subjects
Mental Health, Neurosciences, Cardiovascular, Heart Disease, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Animals, Mice, Anxiety, Brain, Brain Mapping, Emotions, Heart, Behavior, Animal, Electrophysiology, Optogenetics, Insular Cortex, Heart Rate, Channelrhodopsins, Tachycardia, Pacemaker, Artificial, General Science & Technology
Abstract

Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart1-3. However, whether an increased heart rate might itself induce anxiety or fear responses is unclear3-8. Physiological theories of emotion, proposed over a century ago, have considered that in general, there could be an important and even dominant flow of information from the body to the brain9. Here, to formally test this idea, we developed a noninvasive optogenetic pacemaker for precise, cell-type-specific control of cardiac rhythms of up to 900 beats per minute in freely moving mice, enabled by a wearable micro-LED harness and the systemic viral delivery of a potent pump-like channelrhodopsin. We found that optically evoked tachycardia potently enhanced anxiety-like behaviour, but crucially only in risky contexts, indicating that both central (brain) and peripheral (body) processes may be involved in the development of emotional states. To identify potential mechanisms, we used whole-brain activity screening and electrophysiology to find brain regions that were activated by imposed cardiac rhythms. We identified the posterior insular cortex as a potential mediator of bottom-up cardiac interoceptive processing, and found that optogenetic inhibition of this brain region attenuated the anxiety-like behaviour that was induced by optical cardiac pacing. Together, these findings reveal that cells of both the body and the brain must be considered together to understand the origins of emotional or affective states. More broadly, our results define a generalizable approach for noninvasive, temporally precise functional investigations of joint organism-wide interactions among targeted cells during behaviour.

Published
2023

9. Development and Proposal of Military Artificial Intelligence Battlefield Noise Cancellation Model for Secure Joint Operations

Author

Kim, Joosung, Kim, Soo Hyun, Joe, Inwhee, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, and Silhavy, Petr, editor

Published
2024
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19. A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome

Author

Ben-Mahmoud, Afif, Kishikawa, Shotaro, Gupta, Vijay, Leach, Natalia T., Shen, Yiping, Moldovan, Oana, Goel, Himanshu, Hopper, Bruce, Ranguin, Kara, Gruchy, Nicolas, Maas, Saskia M, Lacassie, Yves, Kim, Soo-Hyun, Kim, Woo-Yang, Quade, Bradley J., Morton, Cynthia C., Kim, Cheol-Hee, Layman, Lawrence C., and Kim, Hyung-Goo

Published
2023
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27. Atomic Layer Deposited Supercapacitor Electrodes

Author

Ansari, Mohd Zahid, Kim, Soo-Hyun, Dhara, Arpan, Nandi, Dip K., Hull, Robert, Series Editor, Jagadish, Chennupati, Series Editor, Kawazoe, Yoshiyuki, Series Editor, Kruzic, Jamie, Series Editor, Osgood jr., Richard, Series Editor, Parisi, Jürgen, Series Editor, Pohl, Udo W., Series Editor, Seong, Tae-Yeon, Series Editor, Uchida, Shin-ichi, Series Editor, Wang, Zhiming M., Series Editor, and Kar, Kamal K., editor

Published
2023
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30. Deep brain optogenetics without intracranial surgery

Author

Chen, Ritchie, Gore, Felicity, Nguyen, Quynh-Anh, Ramakrishnan, Charu, Patel, Sneha, Kim, Soo Hyun, Raffiee, Misha, Kim, Yoon Seok, Hsueh, Brian, Krook-Magnusson, Esther, Soltesz, Ivan, and Deisseroth, Karl

Subjects
Substance Misuse, Mental Health, Behavioral and Social Science, Brain Disorders, Neurosciences, Basic Behavioral and Social Science, Biomedical Imaging, Rehabilitation, Neurological, Animals, Brain, Light, Male, Mice, Inbred C57BL, Neurons, Optogenetics, Rats, Ventral Tegmental Area
Abstract

Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision. Using systemic viral delivery of ChRmine, we demonstrate behavioral modulation without surgery, enabling implant-free deep brain optogenetics.

Published
2021

34. Fungal Endophthalmitis Outbreak after Cataract Surgery, South Korea, 2020

Author

Yoon, Soo Jeong, Kim, Soo Hyun, Bahk, Hyun Jung, Ahn, Yeong Seo, Lee, Ji Joo, Kim, Hye Jin, Lim, Ha Jin, Choi, Min Ji, Shin, Jong Hee, and Lee, Yeon-Kyeng

Subjects
Endophthalmitis -- Diagnosis -- Care and treatment, Cataract -- Surgery, Antifungal agents -- Dosage and administration, Health
Abstract

Although the number of cataract surgery procedures is increasing globally because of an aging population, the incidence of postoperative endophthalmitis is declining because hygiene and surgical environments have improved (1,2). [...]

Published
2022
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48. Construction of periodic adapted orthonormal frames on closed space curves

Author

Farouki, Rida T, Kim, Soo Hyun, and Moon, Hwan Pyo

Subjects
Information and Computing Sciences, Engineering, Mathematical Sciences, Rational adapted frames, Closed spatial curves, Arc length constraints, Pythagorean-hodograph curves, Euler-Rodrigues frame, Spatial rigid-body motion, Software Engineering, Information and computing sciences, Mathematical sciences
Abstract

The construction of continuous adapted orthonormal frames along C1 closed–loop spatial curves is addressed. Such frames are important in the design of periodic spatial rigid–body motions along smooth closed paths. The construction is illustrated through the simplest non–trivial context — namely, C1 closed loops defined by a single Pythagorean–hodograph (PH) quintic space curve of a prescribed total arc length. It is shown that such curves comprise a two–parameter family, dependent on two angular variables, and they degenerate to planar curves when these parameters differ by an integer multiple of π. The desired frame is constructed through a rotation applied to the normal–plane vectors of the Euler–Rodrigues frame, so as to interpolate a given initial/final frame orientation. A general solution for periodic adapted frames of minimal twist on C1 closed–loop PH curves is possible, although this incurs transcendental terms. However, the C1 closed–loop PH quintics admit particularly simple rational periodic adapted frames.

Published
2020

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