194 results on '"Kireev, Dmitri"'
Search Results
2. Combining pharmacophore models derived from DNA-encoded chemical libraries with structure-based exploration to predict Tankyrase 1 inhibitors
3. A simulation model of heterochromatin formation at submolecular detail
4. Reprogramming CBX8-PRC1 function with a positive allosteric modulator
5. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
6. Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors
7. UNC5293, a potent, orally available and highly MERTK-selective inhibitor
8. In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot.
9. The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia
10. Efforts toward discovering inhibitors of the SYK SH2–FCER1γ interaction as potential Alzheimer’s disease chemical probes and therapeutics
11. MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer
12. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
13. Identification of Cosalane as an Inhibitor of Human and Murine CC–Chemokine Receptor 7 Signaling via a High-Throughput Screen
14. Machine Learning-driven Fragment-based Discovery of CIB1-directed Anti-Tumor Agents by FRASE-bot
15. Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors
16. Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
17. Supplementary Figure 3 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
18. Supplementary Figure 2 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
19. Supplementary Figure 4 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
20. Supplementary Figure 1 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
21. Data from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
22. Supplementary Figure 5 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
23. Relationship between lysine methyltransferase levels and heterochromatin gene repression in living cells and in silico
24. PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components
25. Dynamics of heterochromatin formation at submolecular resolution
26. Discovery of selective activators of PRC2 mutant EED-I363M
27. Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant
28. Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C
29. Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection
30. Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity
31. List of Contributors
32. Structure-Based Virtual Screening of Commercially Available Compound Libraries
33. Computational Chemical Biology of Methyllysine Histone Effectors
34. Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology
35. AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery
36. Combining Pharmacophore Models Derived from DNA-Encoded Chemical Libraries with Structure-Based Exploration to Predict Tankyrase 1 Inhibitors
37. Generation of the AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery
38. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
39. Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection.
40. Discovery and Development of Cyclic Peptide Inhibitors of CIB1
41. AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery
42. Correction to “A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes”
43. Integrating DNA-encoded chemical libraries with virtual combinatorial library screening: Optimizing a PARP10 inhibitor
44. Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization
45. REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
46. AI-driven 3D design for orphan targets from big PDB/SAR data
47. Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
48. Off-Pocket Activity Cliffs: A Puzzling Facet of Molecular Recognition
49. Supplemental_Material_for_Hull-Ryde_et_al – Supplemental material for Identification of Cosalane as an Inhibitor of Human and Murine CC–Chemokine Receptor 7 Signaling via a High-Throughput Screen
50. DS_773045 – Supplemental material for Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
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