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26 results on '"Kittel, Jochen"'

1. The Effect of a Laser-Based Heat Treatment on the Microstructure of a Superalloy After a Minimally Invasive Repair by Direct Energy Deposition

Author

Müller, Bernd, Backes, Gerhard, Küppers, Wolfgang, Kittel, Jochen, Pirch, Norbert, Hemes, Susanne, Pedersen, Markus, Hatzoglou, Constantinos, Kontis, Paraskevas, Cormier, Jonathan, editor, Edmonds, Ian, editor, Forsik, Stephane, editor, Kontis, Paraskevas, editor, O’Connell, Corey, editor, Smith, Timothy, editor, Suzuki, Akane, editor, Tin, Sammy, editor, and Zhang, Jian, editor

Published
2024
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2. Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial

Author

Schuler, Rahel, Kampschulte, Birgit, Schmidt, Annesuse, Atanasov, Svilen, Dzietko, Mark, Prager, Sebastian, Bialas, Ioana, Kramps, Petra, Beckmann, Sarah, Seidenberg, Jürgen, Majosthusmann, Katja, Potratz, Jenny, van den Heuvel, Alijda, Tekaat, Maria, Dettmers, Susanne, Unterweger, Marie-Therese, Nowak, Heike, Möller, Jens, Thome, Ulrich, Arand, Jörg, Luger, Beate, Maiwald, Christian A, Heideking, Martin, Heckmann, Matthias, Keller-Wacherbauer, Annette, Michel, Holger, Karen, Tanja, Schmid, Anna, Pellkofer, Yasmin, Griesmaier, Elke, Genzel-Boroviczeny, Orsolya, Mata Fernandez, Raquel, Avenarius, Stefan, Czoske, Andrea, Block, Christoph, Schwarz, Simone, Jenke, Andreas, Grass, Tamara, Kuntz, Martin, Fahlbusch, Fabian, Pöschl, Johannes, Metzger, Jule, Ronellenfitsch, Sebastian, Schaible, Thomas, Reinhard, Julia, Trepels-Kottek, Sonja, Bauer, Jacqueline, Herting, Egbert, Henn, Wolfram, Laupert, Annette, Jathe, Rebecca, Meyer, Sascha, Bay, Johannes, Franz, Axel R, Ehrhardt, Harald, Klein, Lars, Petzinger, Jutta, Binder, Christoph, Kirschenhofer, Susanne, Stein, Anja, Hüning, Britta, Heep, Axel, Cloppenburg, Eva, Muyimbwa, Julia, Ott, Torsten, Sandkötter, Julia, Teig, Norbert, Wiegand, Susanne, Schroth, Michael, Kick, Andrea, Wurm, Donald, Gebauer, Corinna, Linnemann, Knud, Kittel, Jochen, Wieg, Christian, Kiechl-Kohlendorfer, Ursula, Schmidt, Susanne, Böttger, Ralf, Thomas, Wolfgang, Brevis Nunez, Francisco, Stockmann, Antje, Kriebel, Thomas, Müller, Andreas, Klotz, Daniel, Morhart, Patrick, Nohr, Donatus, Biesalski, Hans Konrad, Giannopoulou, Eleni Z, Hilt, Susanne, Poryo, Martin, Wagenpfeil, Stefan, Haiden, Nadja, Ruckes, Christian, Ehrlich, Anne, and Gortner, Ludwig

Published
2024
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3. Longitudinal predictors for internalizing and externalizing symptomatology at age 4: KUNO-Kids cohort study.

Author

Jarvers, Irina, Kandsperger, Stephanie, Ecker, Angelika, Brandstetter, Susanne, Kabesch, Michael, Köninger, Angela, Melter, Michael, Kerzel, Sebastian, Kittel, Jochen, Apfelbacher, Christian, and Brunner, Romuald

Subjects
DEVELOPMENTAL psychology, INTERNALIZING behavior, SOCIAL support, SLEEP quality, PRESCHOOL children
Abstract

Introduction: Numerous early-life risk factors are thought to significantly contribute to the development of psychological problems in toddlerhood. However, these factors have seldom been investigated concomitantly and longitudinally, and few studies include both mothers and fathers. This study examines the longitudinal impact of early environmental, parental, and child-specific risk factors on children's internalizing and externalizing symptomatology at age 4. Methods: Families were recruited from a perinatal center at birth and completed self-report questionnaires at birth, 4 weeks postpartum, 6 months postpartum, and annually thereafter. The final population-based sample consisted of n = 560 mothers (and fathers) who gave birth after June 2015, with children who turned 4 years old before March 31, 2021. The primary outcomes, children's internalizing and externalizing symptomatology at age 4, were measured using the Strengthsand Difficulties Questionnaire. Linear mixed effect models were used to estimate growth curves for predictors between 4 weeks and 4 years postpartum, which were subsequently entered into multivariable linear regressions to predict internalizing and externalizing symptomatology at age 4. Results: The study identified several key risk factors: environmental (lack of social support, lower parental education, male sex), parental (poor parental mental health, increased parenting stress, parental sleep difficulties) and child-specific (children's low physical health, children's reduced sleep quality, temperament). Discussion: The findings underscore that most identified risk factors are related to children's temperament, mental and physical health of parents, their experienced stress, and families' social support networks. These insights highlight the importance of targeted interventions focusing on improving parental mental health, reducing stress, and enhancing social support to mitigate early-life psychological problems in children. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc.

Author

Ali, Sanoj, primary, Altamimi, Talal, additional, Annink, Kim, additional, Bartmann, Peter, additional, Beato, Nina, additional, Belker, Kristina, additional, Ben-David, Danielle, additional, Benders, Manon, additional, Bhattacharya, Soume, additional, Anbu Chakkarapani, Aravanan, additional, Charbonneau, Laurence, additional, Cherkerzian, Sara, additional, Chowdhury, Rasheda Arman, additional, Christou, Helen, additional, de Ribaupierre, Dandrine, additional, Dehaes, Mathieu, additional, Domogalla, Caroline, additional, Duerden, Emma G., additional, El-Dib, Mohamed, additional, Elanbari, Mohammed, additional, Elshibiny, Hoda, additional, Engel, Corinna, additional, Felderhoff, Ursula, additional, Flemmer, Andreas W., additional, Franceschini, Maria Angela, additional, Franz, Axel, additional, Garvey, Aisling, additional, Groenendaal, Floris, additional, Gupta, Samir, additional, Hannon, Katie, additional, Hellström-Westas, Lena, additional, Herber-Jonat, Susanne, additional, Holz, Sandra, additional, Hüning, Britta, additional, Inder, Terrie, additional, Jamil, Asma, additional, Jilson, Treesa, additional, Kebaya, Lilian M.N., additional, Keller, Matthias, additional, Khalifa, Aisha Kamil Mohamed, additional, Kim, Seh Hyun, additional, Kittel, Jochen, additional, Koch, Lutz, additional, Kowalczyk, Alexandra, additional, Kühr, Joachim, additional, St. Lawrence, Keith, additional, Lee, Sarah, additional, Marandyuk, Bohdana, additional, Marlow, Neil, additional, Mayorga, Paula Camila, additional, Meyer, Ron, additional, Meyerink, Paige, additional, Miró, Joaquim, additional, More, Kiran, additional, Munk, Aisha, additional, Munster, Chelsea, additional, Musabi, Melab, additional, Nuyt, Anne-Monique, additional, Peters, Jochen, additional, Plum, Achim, additional, Poirier, Nancy, additional, Pöschl, Johannes, additional, Raboisson, Marie-Josée, additional, Robinson, Jill, additional, Roychaudhuri, Sriya, additional, Rüdiger, Mario, additional, Sarközy, Gergely, additional, Saugstad, Ola D., additional, Segerer, Hugo, additional, Soni, Naharmal, additional, Stein, Anja, additional, Steins-Rang, Carola, additional, Sunwoo, John, additional, Szakmar, Eniko, additional, Tang, Lingkai, additional, Taskin, Erdal, additional, Vahidi, Homa, additional, Waldherr, Sina, additional, Wieg, Christian, additional, Winkler, Stefan, additional, Wu, Rong, additional, Yajamanyam, Phani Kiran, additional, and Yapicioglu-Yildizdas, Hacer, additional

Published
2023
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9. Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial

Author

Meyer, Sascha, Bay, Johannes, Franz, Axel R, Ehrhardt, Harald, Klein, Lars, Petzinger, Jutta, Binder, Christoph, Kirschenhofer, Susanne, Stein, Anja, Hüning, Britta, Heep, Axel, Cloppenburg, Eva, Muyimbwa, Julia, Ott, Torsten, Sandkötter, Julia, Teig, Norbert, Wiegand, Susanne, Schroth, Michael, Kick, Andrea, Wurm, Donald, Gebauer, Corinna, Linnemann, Knud, Kittel, Jochen, Wieg, Christian, Kiechl-Kohlendorfer, Ursula, Schmidt, Susanne, Böttger, Ralf, Thomas, Wolfgang, Brevis Nunez, Francisco, Stockmann, Antje, Kriebel, Thomas, Müller, Andreas, Klotz, Daniel, Morhart, Patrick, Nohr, Donatus, Biesalski, Hans Konrad, Giannopoulou, Eleni Z, Hilt, Susanne, Poryo, Martin, Wagenpfeil, Stefan, Haiden, Nadja, Ruckes, Christian, Ehrlich, Anne, Gortner, Ludwig, Schuler, Rahel, Kampschulte, Birgit, Schmidt, Annesuse, Atanasov, Svilen, Dzietko, Mark, Prager, Sebastian, Bialas, Ioana, Kramps, Petra, Beckmann, Sarah, Seidenberg, Jürgen, Majosthusmann, Katja, Potratz, Jenny, van den Heuvel, Alijda, Tekaat, Maria, Dettmers, Susanne, Unterweger, Marie-Therese, Nowak, Heike, Möller, Jens, Thome, Ulrich, Arand, Jörg, Luger, Beate, Maiwald, Christian A, Heideking, Martin, Heckmann, Matthias, Keller-Wacherbauer, Annette, Michel, Holger, Karen, Tanja, Schmid, Anna, Pellkofer, Yasmin, Griesmaier, Elke, Genzel-Boroviczeny, Orsolya, Mata Fernandez, Raquel, Avenarius, Stefan, Czoske, Andrea, Block, Christoph, Schwarz, Simone, Jenke, Andreas, Grass, Tamara, Kuntz, Martin, Fahlbusch, Fabian, Pöschl, Johannes, Metzger, Jule, Ronellenfitsch, Sebastian, Schaible, Thomas, Reinhard, Julia, Trepels-Kottek, Sonja, Bauer, Jacqueline, Herting, Egbert, Henn, Wolfram, Laupert, Annette, and Jathe, Rebecca

Abstract

Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.

Published
2024
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12. Assessment of retinopathy of prematurity regression and reactivation using an artificial intelligence–based vascular severity score

Author

Eilts, Sonja K., Pfeil, Johanna M., Poschkamp, Broder, Krohne, Tim U., Eter, Nicole, Barth, Teresa, Guthoff, Rainer, Lagrèze, Wolf, Grundel, Milena, Bründer, Marie-Christine, Busch, Martin, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Chan, R. V. Paul, Coyner, Aaron S., Ostmo, Susan, Campbell, J. Peter, Stahl, Andreas, Pfeil, Johanna M, Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf A, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G, Krohne, Tim U, Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R, Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Oberacher-Velten, Isabel, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Meltendorf, Synke, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Ehrt, Oliver, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Aisenbrey, Sabine, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Roider, Johann, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, Modlich, Simon, Jandeck, Isabel, Gerding, Heinrich, Smith, Lois E H, Eilts, Sonja K., Pfeil, Johanna M., Poschkamp, Broder, Krohne, Tim U., Eter, Nicole, Barth, Teresa, Guthoff, Rainer, Lagrèze, Wolf, Grundel, Milena, Bründer, Marie-Christine, Busch, Martin, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Chan, R. V. Paul, Coyner, Aaron S., Ostmo, Susan, Campbell, J. Peter, Stahl, Andreas, Pfeil, Johanna M, Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf A, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G, Krohne, Tim U, Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R, Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Oberacher-Velten, Isabel, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Meltendorf, Synke, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Ehrt, Oliver, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Aisenbrey, Sabine, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Roider, Johann, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, Modlich, Simon, Jandeck, Isabel, Gerding, Heinrich, and Smith, Lois E H

Published
2023

13. Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc

Author

Arts-assistenten Kinderen, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Ali, Sanoj, Altamimi, Talal, Annink, Kim, Bartmann, Peter, Beato, Nina, Belker, Kristina, Ben-David, Danielle, Benders, Manon, Bhattacharya, Soume, Anbu Chakkarapani, Aravanan, Charbonneau, Laurence, Cherkerzian, Sara, Chowdhury, Rasheda Arman, Christou, Helen, de Ribaupierre, Dandrine, Dehaes, Mathieu, Domogalla, Caroline, Duerden, Emma G., El-Dib, Mohamed, Elanbari, Mohammed, Elshibiny, Hoda, Engel, Corinna, Felderhoff, Ursula, Flemmer, Andreas W., Franceschini, Maria Angela, Franz, Axel, Garvey, Aisling, Groenendaal, Floris, Gupta, Samir, Hannon, Katie, Hellström-Westas, Lena, Herber-Jonat, Susanne, Holz, Sandra, Hüning, Britta, Inder, Terrie, Jamil, Asma, Jilson, Treesa, Kebaya, Lilian M.N., Keller, Matthias, Khalifa, Aisha Kamil Mohamed, Kim, Seh Hyun, Kittel, Jochen, Koch, Lutz, Kowalczyk, Alexandra, Kühr, Joachim, St Lawrence, Keith, Lee, Sarah, Marandyuk, Bohdana, Marlow, Neil, Mayorga, Paula Camila, Meyer, Ron, Meyerink, Paige, Miró, Joaquim, More, Kiran, Munk, Aisha, Munster, Chelsea, Musabi, Melab, Nuyt, Anne Monique, Peters, Jochen, Plum, Achim, Poirier, Nancy, Pöschl, Johannes, Raboisson, Marie Josée, Robinson, Jill, Roychaudhuri, Sriya, Rüdiger, Mario, Sarközy, Gergely, Saugstad, Ola D., Segerer, Hugo, Soni, Naharmal, Stein, Anja, Steins-Rang, Carola, Sunwoo, John, Szakmar, Eniko, Tang, Lingkai, Taskin, Erdal, Vahidi, Homa, Waldherr, Sina, Wieg, Christian, Winkler, Stefan, Wu, Rong, Yajamanyam, Phani Kiran, Yapicioglu-Yildizdas, Hacer, Arts-assistenten Kinderen, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Ali, Sanoj, Altamimi, Talal, Annink, Kim, Bartmann, Peter, Beato, Nina, Belker, Kristina, Ben-David, Danielle, Benders, Manon, Bhattacharya, Soume, Anbu Chakkarapani, Aravanan, Charbonneau, Laurence, Cherkerzian, Sara, Chowdhury, Rasheda Arman, Christou, Helen, de Ribaupierre, Dandrine, Dehaes, Mathieu, Domogalla, Caroline, Duerden, Emma G., El-Dib, Mohamed, Elanbari, Mohammed, Elshibiny, Hoda, Engel, Corinna, Felderhoff, Ursula, Flemmer, Andreas W., Franceschini, Maria Angela, Franz, Axel, Garvey, Aisling, Groenendaal, Floris, Gupta, Samir, Hannon, Katie, Hellström-Westas, Lena, Herber-Jonat, Susanne, Holz, Sandra, Hüning, Britta, Inder, Terrie, Jamil, Asma, Jilson, Treesa, Kebaya, Lilian M.N., Keller, Matthias, Khalifa, Aisha Kamil Mohamed, Kim, Seh Hyun, Kittel, Jochen, Koch, Lutz, Kowalczyk, Alexandra, Kühr, Joachim, St Lawrence, Keith, Lee, Sarah, Marandyuk, Bohdana, Marlow, Neil, Mayorga, Paula Camila, Meyer, Ron, Meyerink, Paige, Miró, Joaquim, More, Kiran, Munk, Aisha, Munster, Chelsea, Musabi, Melab, Nuyt, Anne Monique, Peters, Jochen, Plum, Achim, Poirier, Nancy, Pöschl, Johannes, Raboisson, Marie Josée, Robinson, Jill, Roychaudhuri, Sriya, Rüdiger, Mario, Sarközy, Gergely, Saugstad, Ola D., Segerer, Hugo, Soni, Naharmal, Stein, Anja, Steins-Rang, Carola, Sunwoo, John, Szakmar, Eniko, Tang, Lingkai, Taskin, Erdal, Vahidi, Homa, Waldherr, Sina, Wieg, Christian, Winkler, Stefan, Wu, Rong, Yajamanyam, Phani Kiran, and Yapicioglu-Yildizdas, Hacer

Published
2023

15. Up-date on the NeoVitaA Trial: Obstacles, challenges, perspectives, and local experiences

Author

Meyer, Sascha, Gortner, Ludwig, Meyer, Sascha, Bay, Johannes, Gortner, Ludwig, Ehrlich, Anne, Ruckes, Christian, Seidenberg, Jürgen, Muyimbwa, Julia, Wieg, Christian, Stangl, Oliver, Böttger, Ralf, Avenarius, Stefan, Völkl, Thomas, Topf, Hans-Georg, Heimann, Konrad, Trepels-Kottek, Sonja, Keller-Wackerbauer, Annette, Kittel, Jochen, Thomas, Wolfgang, Czoske, Andrea, Genzel-Boroviczény, Orsolya, Mata Fernandez, Raquel, Ott, Torsten, Werner, Claudius, Felderhoff-Müser, Ursula, Stein, Anja, Hahn, Eva, Jenke, Andreas, Bauer, Jaqueline, Knuf, Markus, Wurm, Donald, Möller, Jens, Beedgen, Bernd, Pöschl, Johannes, Fritsche, Kathrin, Jung, Claudia, Müller, Andreas, Wenzing, Lars, Wiegand, Susanne, Teig, Norbert, Franz, Axel, Poets, Christian, Gebauer, Corinna, Thome, Ulrich, Berger, Angelika, Kreissl, Alexandra, Mönig, Tina, Nuñez, Francisco Brevis, Lysko, Stephan, Taskaya, Gediz, Holzgartner, Nicole, Schroth, Michael, Kiechl, Ursula, Neubauer, Vera, Zemlin, Michael, Maier, Rolf F., Ehrhardt, Harald, Klein, Lars, Reinhard, Julia, Schaible, Thomas, Linnemann, Knud, Heckmann, Matthias, Wagenpfeil, Stefan, Biesalski, Hans Konrad, Nohr, Donatus, and NeoVitaA Trial investigators

Published
2017
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16. Development of a novel green coating process with laser

Author

Zhong, Chongliang, Backes, Gerhard, Johann, Lukas Martin, Kittel, Jochen, Schopphoven, Thomas, Küppers, Wolfgang, and Publica

Subjects
Multidisciplinary, Engineering, Material Science, ddc:600
Abstract

Scientific reports 12(1), 6314 (2022). doi:10.1038/s41598-022-10351-4, Published by Macmillan Publishers Limited, part of Springer Nature, [London]

Published
2021
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17. Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity : a randomized clinical trial

Author

Stahl, Andreas, Krohne, Tim U., Eter, Nicole, Oberacher-Velten, Isabel, Guthoff, Rainer, Meltendorf, Synke, Ehrt, Oliver, Aisenbrey, Sabine, Roider, Johann, Gerding, Heinrich, Jandeck, Claudia, Smith, Lois E. H., Walz, Johanna M., Bühler, Anima, Daniel, Moritz, Felzmann, Susanne, Gross, Nicolai, Horn, Stefanie, Lagrèze, Wolf, Molnár, Fanni, Müller, Claudia, Reichl, Sabine, Reiff, Charlotte, Richter, Olga, Stech, Milena, Hentschel, Roland, Stavropolou, Dimitria, Tautz, Juliane, Bartsch, Kerstin, Braunstein, Jennifer, Brinken, Ralf, Brinkmann, Christian Karl, Czauderna, Joanna, Dralle, Wiebke, Gliem, Martin, Goebel, Arno, Heymer, Philipp, Hofmann, Martina, Holz, Frank G., Kupitz, David, Müller, Philipp, Petrak, Michael, Schmitz, Eva Janine, Schmitz-Valckenberg, Steffen, Schröder, Moritz, Steinberg, Julia, Supé, Julia, Kant, Evelyn, Kunze, Diana, Müller, Andreas, Adorf, Adeline, Alex, Anne, Alten, Florian, Clemens, Christoph R., Falkenau, Silvia, Friedhoff, Caroline, Loos, Desiree Sandra, Mihailovic, Natasa, Termühlen, Julia, Uhlig, Constantin, Hörnig-Franz, Isabell, Rieger-Fackeldey, Esther, Tekaat, Maria, Werner, Claudius, Altmann, Mathias, Barth, Theresa, Blecha, Christiane, Brandl-Rühle, Sabine, Helbig, Horst, Hufendiek, Karsten, Jägle, Herbert, Konrad, Julia, Kopetzky, Eva, Lehmann, Fabian, Keller-Wackerbauer, Annette, Kittel, Jochen, Segerer, Hugo, Ackermann, Phillip, Benga, Jemina, Guthoff, Tanja, Kleinert, Elena, Mayatepek, Ertan, Schrader, Stefan, Völker, Magdalena, Höhn, Thomas, Lohmeier, Klaus, Sabir, Hemmen, Brevis, Francisco, Mönig, Tina, Schwarz, Simone, Ehmer, Angela, Schuart, Claudia, Avenarius, Stefan, Böttger, Ralf, Apel, Christoph, Bergmann, Anne, Herrmann, Karsten, Ockert-Schön, Franziska, Wegener, Sabine, Nentwich, Martin, Pressler, Angelika, Rudolph, Günther, Genzel-Boroviczeny, Orsolya, Schmidt, Susanne, Münch, Hans-Georg, Thilmany, Claude, Bruckmann, Anna, Dimopoulos, Spyridon, Hagemann, Ulrike, Inhoffen, Werner, Partsch, Michael, Schrader, Merle, Süsskind, Daniela, Völker, Michael, Bialkowski, Anja, Müller-Hansen, Ingo, Gerberth, Andrea, Hasselbach, Heike Christine, Lindemann, Solveig, Purtskhvanidze, Konstantine, Raffel, Yvonne, Schröder, Greta, Szymanek, Beke, Tode, Jan, Bendiks, Meike, and Modlich, Simon

Subjects
Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, genetic structures, Bevacizumab, Medizin, Angiogenesis Inhibitors, Pilot Projects, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Germany, Ranibizumab, Internal medicine, Clinical endpoint, Humans, Medicine, Retinopathy of Prematurity, Dosing, Original Investigation, Dose-Response Relationship, Drug, business.industry, Standard treatment, Infant, Newborn, Retinopathy of prematurity, Odds ratio, medicine.disease, Treatment Outcome, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Female, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Importance Anti–vascular endothelial growth factor (VEGF) therapies are a novel treatment option in retinopathy of prematurity (ROP). Data on dosing, efficacy, and safety are insufficient. Objective To investigate lower doses of anti-VEGF therapy with ranibizumab, a substance with a significantly shorter systemic half-life than the standard treatment, bevacizumab. Design, Setting, and Participants This randomized, multicenter, double-blind, investigator-initiated trial at 9 academic medical centers in Germany compared ranibizumab doses of 0.12 mg vs 0.20 mg in infants with bilateral aggressive posterior ROP; ROP stage 1 with plus disease, 2 with plus disease, or 3 with or without plus disease in zone I; or ROP stage 3 with plus disease in posterior zone II. Patients were recruited between September 2014 and August 2016. Twenty infants were screened and 19 were randomized. Interventions All infants received 1 baseline ranibizumab injection per eye. Reinjections were allowed in case of ROP recurrence after at least 28 days. Main Outcomes and Measures The primary end point was the number of infants who did not require rescue therapy at 24 weeks. Key secondary end points included time-to-event analyses, progression of physiologic vascularization, and plasma VEGF levels. Stages of ROP were photodocumented and reviewed by an expert committee. Results Nineteen infants with ROP were enrolled (9 [47.4%] female; median [range] postmenstrual age at first treatment, 36.4 [34.7-39.7] weeks), 3 of whom died during the study (1 in the 0.12-mg group and 2 in the 0.20-mg group). Of the surviving infants, 8 (88.9%) (17 eyes [94.4%]) in the 0.12-mg group and 6 (85.7%) (13 eyes [92.9%]) in the 0.20-mg group did not require rescue therapy. Both ranibizumab doses were equally successful in controlling acute ROP (Cochran-Mantel-Haenszel analysis; odds ratio, 1.88; 95% CI, 0.26-13.49;P = .53). Physiologic intraretinal vascularization was superior in the 0.12-mg group. The VEGF plasma levels were not systematically altered in either group. Conclusions and Relevance This pilot study demonstrates that ranibizumab is effective in controlling acute ROP and that 24% of the standard adult dose (0.12 mg) appears equally effective as 40% (0.20 mg). Superior vascularization of the peripheral retina with 0.12 mg of ranibizumab indicates that the lower dose may be favorable. Unchanged plasma VEGF levels point toward a limited systemic drug exposure after ranibizumab. Trial Registration clinicaltrials.gov Identifier:NCT02134457and clinicaltrialsregister.eu Identifier:2013-002539-13.

Published
2018

19. NOD2 Loss-of-Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low-birth-weight Infants

Author

Haertel, Christoph, Hartz, Annika, Pagel, Julia, Rupp, Jan, Stein, Anja, Kribs, Angela, Mueller, Andreas, Haase, Roland, Gille, Christian, Boettger, Ralf, Kittel, Jochen, Jensen, Reinhard, Wieg, Christian, Herting, Egbert, Goepel, Wolfgang, Haertel, Christoph, Hartz, Annika, Pagel, Julia, Rupp, Jan, Stein, Anja, Kribs, Angela, Mueller, Andreas, Haase, Roland, Gille, Christian, Boettger, Ralf, Kittel, Jochen, Jensen, Reinhard, Wieg, Christian, Herting, Egbert, and Goepel, Wolfgang

Abstract

Background:NOD2 loss-of-function mutations, that is, R702W [rs2066844], G908R [rs2066845], and Leu1007fsinsC [rs5743293], have been linked to inflammatory bowel diseases. It is yet unknown whether these variants are also associated with necrotizing enterocolitis (NEC) or focal intestinal perforation (FIP) in infants of very low birth weight (VLBW).Methods:To test this hypothesis, we genotyped 9082 VLBW infants with European ancestry enrolled in a prospective, population-based cohort study of the German Neonatal Network. We assessed the effect of the NOD2 gene variants on the risk for major morbidities of the gastrointestinal tract, that is, NEC/FIP requiring surgery in multivariable logistic regression analyses.Results:In the whole cohort of VLBW infants, carriers of 2 NOD2 variant alleles had an increased risk for NEC requiring surgery (odds ratio [OR], 3.57; 95% confidence interval [CI], 1.27-10.04; P = 0.03) and NEC or FIP requiring surgery (OR, 3.81; 95% CI, 1.70-8.51; P = 0.004) as compared with wild-type genotypes. In a multivariable logistic regression analysis including gestational age, birth weight, gender, multiple birth, and inborn delivery, the association between 2 NOD2 variant alleles and NEC surgery (OR, 4.14; 95% CI, 1.41-12.12; P = 0.009), FIP surgery (OR, 3.50; 95% CI, 1.02-12.04; P = 0.047), and NEC or FIP surgery (OR, 4.10; 95% CI, 1.74-9.73; P = 0.001) proved to be independent. We also performed a regression analysis in the subgroup of infants with available information on Lactobacillus acidophilus/Bifidobacterium infantis probiotic supplementation (n = 3638). Although probiotics had a protective effect on NEC and NEC or FIP requiring surgery, the NOD2 variants had no significant impact in this subgroup.Conclusions:VLBW infants carrying 2 NOD2 genetic risk factors of inflammatory bowel disease in adults have an increased risk for severe gastrointestinal complications, such as NEC requiring surgery. Therefore, infants might benefit from NOD2 geno

Published
2016

21. NOD2 Loss-of-Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low-birth-weight Infants

Author

Härtel, Christoph, primary, Hartz, Annika, additional, Pagel, Julia, additional, Rupp, Jan, additional, Stein, Anja, additional, Kribs, Angela, additional, Müller, Andreas, additional, Haase, Roland, additional, Gille, Christian, additional, Böttger, Ralf, additional, Kittel, Jochen, additional, Jensen, Reinhard, additional, Wieg, Christian, additional, Herting, Egbert, additional, and Göpel, Wolfgang, additional

Published
2016
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26. [Frequency of Utilization of Medical and Paramedical Care in Infants with Excessive Crying: Cross- Sectional Analysis and Parent Survey].

Author

Kittel J, Nonnenmacher L, Apfelbacher C, Seelbach-Göbel B, Kabesch M, Melter M, and Brandstetter S

Abstract

Background: Infants can present in the first year of life with excessive, recurrent crying without an apparent illness or failure to thrive. The excessive crying results in a wide variety of problems for infants, parents and health care service., Objectives: This study aimed at evaluating how often parents of children with excessive crying seek help in the medical and paramedical health care system and which therapies are prescribed., Materials and Methods: This study uses data collected within KUNO Kids health study. Families who participated completed questionnaires 4 weeks after birth and answered questions which screened for excessive crying. Families whose child was screened positive completed an additional questionnaire on symptoms, parental management and health care utilization. Data were analysed using descriptive statistics., Results: We received 238 questionnaires from children with excessive crying, 105 fulfilled the modified Wessel criteria. Of these 37 children (36%) were seen by a pediatrician because of crying. 57 (55%) received medications by the pediatrician. 51 (49%) of the parents specified that they also used paramedical therapies due to crying or whining, most often osteopathy. 45 (43%) adapted their own nutrition or their child's nutrition., Conclusions: Our study shows that parents experience problems in dealing excessive crying. Frequent consultations with pediatricians or use of paramedical therapies are common, demanding additional resources. The parents received different diagnoses for excessive crying. Available drugs like Simeticon, homeopathy or manual therapy are recommended and applied despite largely missing evidence., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht, (Thieme. All rights reserved.)

Published
2023
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