22 results on '"Knapp, Barbara"'
Search Results
2. Usher syndrome proteins ADGRV1 (USH2C) and CIB2 (USH1J) interact and share a common interactome containing TRiC/CCT-BBS chaperonins
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Linnert, Joshua, primary, Knapp, Barbara, additional, Güler, Baran E., additional, Boldt, Karsten, additional, Ueffing, Marius, additional, and Wolfrum, Uwe, additional
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- 2023
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3. Adhesion Class GPCRs in GtoPdb v.2023.1
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Arac-Ozkan, Demet, primary, Aust, Gabriela, primary, Bonner, Tom I., primary, Cappallo-Obermann, Heike, primary, Formstone, Caroline, primary, Hamann, Jörg, primary, Harty, Breanne, primary, Heyne, Henrike, primary, Kirchhoff, Christiane, primary, Knapp, Barbara, primary, Krishnan, Arunkumar, primary, Langenhan, Tobias, primary, Le Duc, Diana, primary, Lin, Hsi-Hsien, primary, Martinelli, David C., primary, Monk, Kelly, primary, Piao, Xianhua, primary, Prömel, Simone, primary, Schöneberg, Torsten, primary, Schiöth, Helgi, primary, Singer, Kathleen, primary, Stacey, Martin, primary, Ushkaryov, Yuri, primary, Wolfrum, Uwe, primary, and Xu, Lei, primary
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- 2023
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4. Adhesion GPCR-Related Protein Networks
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Knapp, Barbara, Wolfrum, Uwe, Barrett, James E., Editor-in-chief, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Rosenthal, Walter, Series editor, Wang, KeWei, Series editor, Langenhan, Tobias, editor, and Schöneberg, Torsten, editor
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- 2016
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5. Affinity Proteomics Identifies Interaction Partners and Defines Novel Insights into the Function of the Adhesion GPCR VLGR1/ADGRV1
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Knapp, Barbara, primary, Roedig, Jens, additional, Roedig, Heiko, additional, Krzysko, Jacek, additional, Horn, Nicola, additional, Güler, Baran E., additional, Kusuluri, Deva Krupakar, additional, Yildirim, Adem, additional, Boldt, Karsten, additional, Ueffing, Marius, additional, Liebscher, Ines, additional, and Wolfrum, Uwe, additional
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- 2022
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6. Der nachträgliche Hauptschulabschluss: zentrale Erfolgsvoraussetzungen aus Sicht der arbeitsmarktpolitischen Praxis
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Biermeier, Sandra, Dietz, Martin, Dony, Elke, Greger, Sabine, and Knapp, Barbara
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Berufsausbildung ,Arbeitsmarktintegration ,Schulabschluss ,Bildung ,Arbeitsmarktpolitik - Abstract
Trotz des Rechtsanspruchs auf den nachträglichen Erwerb des Hauptschulabschlusses hat ein Teil der unter 35-Jährigen noch immer keinen allgemeinbildenden Schulabschluss. Damit mehr Menschen diese Option ergreifen, werden vor allem Bildungsangebote benötigt, die auf deren individuelle Möglichkeiten, Fähigkeiten und Lebensumstände zugeschnitten sind. Darauf deuten die Ergebnisse einer qualitativen Befragung hin, die das IAB mit Fachkräften aus Jobcentern, Arbeitsagenturen und Bildungsträgern durchgeführt hat., IAB-Forum
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- 2022
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7. Characterization of the ternary Usher syndrome SANS/ush2a/whirlin protein complex
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Sorusch, Nasrin, Bauß, Katharina, Plutniok, Janet, Samanta, Ananya, Knapp, Barbara, Nagel-Wolfrum, Kerstin, and Wolfrum, Uwe
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- 2017
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8. Adhesion GPCR-Related Protein Networks
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Knapp, Barbara, primary and Wolfrum, Uwe, additional
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- 2016
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9. Adhesion Class GPCRs in GtoPdb v.2021.3
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Arac-Ozkan, Demet, primary, Aust, Gabriela, primary, Bonner, Tom I., primary, Cappallo-Obermann, Heike, primary, Formstone, Caroline, primary, Hamann, Jörg, primary, Harty, Breanne, primary, Heyne, Henrike, primary, Kirchhoff, Christiane, primary, Knapp, Barbara, primary, Krishnan, Arunkumar, primary, Langenhan, Tobias, primary, Le Duc, Diana, primary, Lin, Hsi-Hsien, primary, Martinelli, David C., primary, Monk, Kelly, primary, Piao, Xianhua, primary, Prömel, Simone, primary, Schöneberg, Torsten, primary, Schiöth, Helgi, primary, Singer, Kathleen, primary, Stacey, Martin, primary, Ushkaryov, Yuri, primary, Wolfrum, Uwe, primary, and Xu, Lei, primary
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- 2021
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10. SANS (USH1G) Molecularly Links the Human Usher Syndrome Protein Network to the Intraflagellar Transport Module by Direct Binding to IFT-B Proteins
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Sorusch, Nasrin, primary, Yildirim, Adem, additional, Knapp, Barbara, additional, Janson, Julia, additional, Fleck, Wiebke, additional, Scharf, Caroline, additional, and Wolfrum, Uwe, additional
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- 2019
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11. Adhesion Class GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
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Arac-Ozkan, Demet, primary, Aust, Gabriela, primary, Bonner, Tom I., primary, Cappallo-Obermann, Heike, primary, Formstone, Caroline, primary, Hamann, Jörg, primary, Harty, Breanne, primary, Heyne, Henrike, primary, Kirchhoff, Christiane, primary, Knapp, Barbara, primary, Krishnan, Arunkumar, primary, Langenhan, Tobias, primary, Le Duc, Diana, primary, Lin, Hsi-Hsien, primary, Martinelli, David C., primary, Monk, Kelly, primary, Piao, Xianhua, primary, Prömel, Simone, primary, Schöneberg, Torsten, primary, Schiöth, Helgi, primary, Singer, Kathleen, primary, Stacey, Martin, primary, Ushkaryov, Yuri, primary, Wolfrum, Uwe, primary, and Xu, Lei, primary
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- 2019
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12. Affinity proteomics identifies novel functional modules related to adhesion GPCRs
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Knapp, Barbara, primary, Roedig, Jens, additional, Boldt, Karsten, additional, Krzysko, Jacek, additional, Horn, Nicola, additional, Ueffing, Marius, additional, and Wolfrum, Uwe, additional
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- 2019
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13. CiliaCarta: An integrated and validated compendium of ciliary genes
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van Dam, Teunis J. P., primary, Kennedy, Julie, additional, van der Lee, Robin, additional, de Vrieze, Erik, additional, Wunderlich, Kirsten A., additional, Rix, Suzanne, additional, Dougherty, Gerard W., additional, Lambacher, Nils J., additional, Li, Chunmei, additional, Jensen, Victor L., additional, Leroux, Michel R., additional, Hjeij, Rim, additional, Horn, Nicola, additional, Texier, Yves, additional, Wissinger, Yasmin, additional, van Reeuwijk, Jeroen, additional, Wheway, Gabrielle, additional, Knapp, Barbara, additional, Scheel, Jan F., additional, Franco, Brunella, additional, Mans, Dorus A., additional, van Wijk, Erwin, additional, Képès, François, additional, Slaats, Gisela G., additional, Toedt, Grischa, additional, Kremer, Hannie, additional, Omran, Heymut, additional, Szymanska, Katarzyna, additional, Koutroumpas, Konstantinos, additional, Ueffing, Marius, additional, Nguyen, Thanh-Minh T., additional, Letteboer, Stef J. F., additional, Oud, Machteld M., additional, van Beersum, Sylvia E. C., additional, Schmidts, Miriam, additional, Beales, Philip L., additional, Lu, Qianhao, additional, Giles, Rachel H., additional, Szklarczyk, Radek, additional, Russell, Robert B., additional, Gibson, Toby J., additional, Johnson, Colin A., additional, Blacque, Oliver E., additional, Wolfrum, Uwe, additional, Boldt, Karsten, additional, Roepman, Ronald, additional, Hernandez-Hernandez, Victor, additional, and Huynen, Martijn A., additional
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- 2019
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14. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
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Boldt, Karsten, van Reeuwijk, Jeroen, Dougherty, Gerard, Lamers, Ideke J C, Coene, Karlien L M, Arts, Heleen H, Betts, Matthew J, Beyer, Tina, Bolat, Emine, Gloeckner, Christian Johannes, Haidari, Khatera, Hetterschijt, Lisette, Lu, Qianhao, Iaconis, Daniela, Jenkins, Dagan, Klose, Franziska, Knapp, Barbara, Latour, Brooke, Letteboer, Stef J F, Marcelis, Carlo L, Mitic, Dragana, Morleo, Manuela, Oud, Machteld M, Koutroumpas, Konstantinos, Riemersma, Moniek, Rix, Susan, Terhal, Paulien A, Toedt, Grischa, van Dam, Teunis J P, de Vrieze, Erik, Wissinger, Yasmin, Wu, Ka Man, Apic, Gordana, Beales, Philip L, Nguyen, Thanh-Minh T, Blacque, Oliver E, Gibson, Toby J, Huynen, Martijn A, Katsanis, Nicholas, Kremer, Hannie, Omran, Heymut, van Wijk, Erwin, Wolfrum, Uwe, Kepes, François, Davis, Erica E, Texier, Yves, Franco, Brunella, Giles, Rachel H, Ueffing, Marius, Russell, Robert B, Roepman, Ronald, Group, UK10K Rare Diseases, Al-Turki, Saeed, Anderson, Carl, Antony, Dinu, Barroso, Inês, van Beersum, Sylvia E C, Bentham, Jamie, Bhattacharya, Shoumo, Carss, Keren, Chatterjee, Krishna, Cirak, Sebahattin, Cosgrove, Catherine, Danecek, Petr, Durbin, Richard, Fitzpatrick, David, Floyd, Jamie, Horn, Nicola, Reghan Foley, A., Franklin, Chris, Futema, Marta, Humphries, Steve E, Hurles, Matt, Joyce, Chris, McCarthy, Shane, Mitchison, Hannah M, Muddyman, Dawn, Muntoni, Francesco, Willer, Jason R, O'Rahilly, Stephen, Onoufriadis, Alexandros, Payne, Felicity, Plagnol, Vincent, Raymond, Lucy, Savage, David B, Scambler, Peter, Schmidts, Miriam, Schoenmakers, Nadia, Semple, Robert, Mans, Dorus A, Serra, Eva, Stalker, Jim, van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Walter, Klaudia, Whittall, Ros, Williamson, Kathy, Boldt, K, van Reeuwijk, J, Lu, Q, Koutroumpas, K, Nguyen, Tmt, Texier, Y, van Beersum, Sec, Horn, N, Willer, Jr, Mans, Da, Dougherty, G, Lamers, Ijc, Coene, Klm, Arts, Hh, Betts, Mj, Beyer, T, Bolat, E, Gloeckner, Cj, Haidari, K, Hetterschijt, L, Iaconis, D, Jenkins, D, Klose, F, Knapp, B, Latour, B, Letteboer, Sjf, Marcelis, Cl, Mitic, D, Morleo, M, Oud, Mm, Riemersma, M, Rix, S, Terhal, Pa, Toedt, G, van Dam, Tjp, de Vrieze, E, Wissinger, Y, Wu, Km, Apic, G, Beales, Pl, Blacque, Oe, Gibson, Tj, Huynen, Ma, Katsanis, N, Kremer, H, Omran, H, van Wijk, E, Wolfrum, U, Kepes, F, Davis, Ee, Franco, B, Giles, Rh, Ueffing, M, Russell, Rb, Roepman, R, Boldt, Karsten, Van Reeuwijk, Jeroen, Lu, Qianhao, Koutroumpas, Konstantino, Nguyen, Thanh Minh T., Texier, Yve, Van Beersum, Sylvia E. C., Horn, Nicola, Willer, Jason R., Mans, Dorus A., Dougherty, Gerard, Lamers, Ideke J. C., Coene, Karlien L. M., Arts, Heleen H., Betts, Matthew J., Beyer, Tina, Bolat, Emine, Gloeckner, Christian Johanne, Haidari, Khatera, Hetterschijt, Lisette, Iaconis, Daniela, Jenkins, Dagan, Klose, Franziska, Knapp, Barbara, Latour, Brooke, Letteboer, Stef J. F., Marcelis, Carlo L., Mitic, Dragana, Morleo, Manuela, Oud, Machteld M., Riemersma, Moniek, Rix, Susan, Terhal, Paulien A., Toedt, Grischa, Van Dam, Teunis J. P., De Vrieze, Erik, Wissinger, Yasmin, Wu, Ka Man, Al Turki, Saeed, Anderson, Carl, Antony, Dinu, Barroso, Inê, Bentham, Jamie, Bhattacharya, Shoumo, Carss, Keren, Chatterjee, Krishna, Cirak, Sebahattin, Cosgrove, Catherine, Danecek, Petr, Durbin, Richard, Fitzpatrick, David, Floyd, Jamie, Foley, A. Reghan, Franklin, Chri, Futema, Marta, Humphries, Steve E., Hurles, Matt, Joyce, Chri, Mccarthy, Shane, Mitchison, Hannah M., Muddyman, Dawn, Muntoni, Francesco, O'Rahilly, Stephen, Onoufriadis, Alexandro, Payne, Felicity, Plagnol, Vincent, Raymond, Lucy, Savage, David B., Scambler, Peter, Schmidts, Miriam, Schoenmakers, Nadia, Semple, Robert, Serra, Eva, Stalker, Jim, Van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Walter, Klaudia, Whittall, Ro, Williamson, Kathy, Apic, Gordana, Beales, Philip L., Blacque, Oliver E., Gibson, Toby J., Huynen, Martijn A., Katsanis, Nichola, Kremer, Hannie, Omran, Heymut, Van Wijk, Erwin, Wolfrum, Uwe, Kepes, Françoi, Davis, Erica E., Franco, Brunella, Giles, Rachel H., Ueffing, Mariu, Russell, Robert B., and Roepman, Ronald
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Proteomics ,0301 basic medicine ,Systems Analysis ,DNA Mutational Analysis ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,General Physics and Astronomy ,Datasets as Topic ,methods [Chromatography, Affinity] ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Chromatography, Affinity ,Mass Spectrometry ,Protein Interaction Mapping ,therapy [Ciliopathies] ,genetics [Ciliopathies] ,methods [Molecular Targeted Therapy] ,Molecular Targeted Therapy ,Protein Interaction Maps ,Multidisciplinary ,Cilium ,Chemistry (all) ,abnormalities [Spine] ,pathology [Ciliopathies] ,genetics [Muscle Hypotonia] ,therapy [Muscle Hypotonia] ,Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] ,metabolism [Proteins] ,isolation & purification [Proteins] ,physiology [Biological Transport] ,3. Good health ,Cell biology ,Vesicular transport protein ,pathology [Dwarfism] ,metabolism [Cilia] ,Muscle Hypotonia ,ddc:500 ,pathology [Muscle Hypotonia] ,pathology [Spine] ,genetics [Dwarfism] ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] ,Science ,Dwarfism ,Exocyst ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,Physics and Astronomy (all) ,03 medical and health sciences ,Intraflagellar transport ,Ciliogenesis ,Organelle ,Humans ,Cilia ,Biochemistry, Genetics and Molecular Biology (all) ,Proteins ,Biological Transport ,General Chemistry ,therapy [Dwarfism] ,Fibroblasts ,genetics [Proteins] ,Ciliopathies ,Spine ,methods [Protein Interaction Mapping] ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,030104 developmental biology ,Proteostasis ,HEK293 Cells ,methods [Proteomics] - Abstract
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a high-resolution network that reveals organelle-specific interactions and complexes not apparent in larger studies, and links vesicle transport, the cytoskeleton, signalling and ubiquitination to ciliary signalling and proteostasis. We observe sub-complexes in exocyst and intraflagellar transport complexes, which we validate biochemically, and by probing structurally predicted, disruptive, genetic variants from ciliary disease patients. The landscape suggests other genetic diseases could be ciliary including 3M syndrome. We show that 3M genes are involved in ciliogenesis, and that patient fibroblasts lack cilia. Overall, this organelle-specific targeting strategy shows considerable promise for Systems Medicine., Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases.
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- 2016
15. Beratung und Vermittlung von Flüchtlingen
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Knapp, Barbara, Bähr, Holger, Dietz, Martin, Dony, Elke, Fausel, Gudrun, Müller, Maren, and Strien, Karsten
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ddc:330 - Abstract
Die Vermittlung von Flüchtlingen in Arbeit oder Ausbildung trägt wesentlich zu ihrer gesellschaftlichen Integration bei und stellt die öffentliche Arbeitsverwaltung vor besondere Herausforderungen. Viele Flüchtlinge haben eine hohe Arbeitsmotivation, sprechen jedoch häufig nicht oder schlecht Deutsch und bringen keine Berufsqualifizierung mit, die in Deutschland anerkannt wird. Zudem haben Flüchtlinge, die bereits einer Erwerbsarbeit nachgehen, diese häufig durch persönliche Kontakte zu Verwandten, Freunden oder Bekannten gefunden. Vor diesem Hintergrund ergibt sich die Forschungsfrage, die mit der vorliegenden Studie beantwortet werden soll: Welchen Einfluss übt die Beratung und Vermittlung von Flüchtlingen in Arbeitsagenturen auf die Arbeitsmarktintegration dieser Personen aus? Die Studie baut auf der wissenschaftlichen Begleitung des Modellprojekts 'Early Intervention - frühzeitige Arbeitsmarktintegration von Asylbewerbern' auf. An fünf Standorten wurden qualitative Fallstudien durchgeführt, die den Prozess der Beratung und Vermittlung von Flüchtlingen beleuchten. Die Studie beschreibt, wie Arbeitsagenturen interne Strukturen schaffen und externe Kooperationen eingehen, um Flüchtlinge in den Arbeitsmarkt zu integrieren. Es werden verschiedene Wege in den Arbeitsmarkt aufgezeigt. Dabei ist der persönliche Kontakte zwischen Flüchtlingen und Arbeitgebern von besonderer Bedeutung für die Aufnahme einer Arbeit oder einer Ausbildung. Allerdings wird ebenfalls offenbar, dass viele Aktivitäten und Angebote der Arbeitsagenturen zeitlich und systematisch vor der eigentlichen Arbeitsvermittlung, d.h. dem Zusammenführen von arbeitsuchenden Personen und offenen Stellen, ansetzen. Insbesondere Kurse zum Erlernen der deutschen Sprache, Maßnahmen zur Erfassung von Kompetenzen und Beratungen zur beruflichen Orientierung gehen der eigentlichen Arbeitsvermittlung voraus. Labour market integration of refugees contributes to their integration into society and constitutes a particular challenge of public employment services. Many refugees are highly motivated to get a job. However, they often do not or hardly speak German and do not have any vocational qualification acknowledged in Germany. Furthermore, refugees find work by means of social contact with relatives, friends or acquaintances without involving the public employment service. Given the challenge of public employment services to integrate refugees into the labour market, this study seeks to answer the research question: How do employment agencies influence the labour market integration of refugees? The study takes up the findings of an evaluation of the pilot scheme "Early Intervention - Early Labour Market Integration of Asylum Seekers". In five employment agency districts, qualitative case studies have been conducted in order to examine the process of labour market advice and job placement of refugees. The study describes how employment agencies create internal structures and enter into external co-operation in order to integrate refugees into the labour market. Furthermore, it identifies different ways into the labour market. It is shown that face-to-face contact between refugees and employers is essential to take up a job or a training place. However, it is also shown that many activities of the employment agencies occur prior to the matching between jobseekers and job vacancies. In particular, this applies to language courses, competence assessment as well as vocational guidance and counselling orientation.
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- 2017
16. Identification of Protein Complexes Associated with the Usher Syndrome 2C and Epilepsy-Associated Protein VLGR1 Applying Affinity Proteomics
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Knapp, Barbara, primary, Krupakar Kusuluri, Deva, primary, Horn, Nicola, primary, Boldt, Karsten, primary, Ueffing, Marius, primary, and Wolfrum, Uwe, primary
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- 2017
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17. Diversity Management und soziale Schließung in Betrieben in Deutschland: Ergebnisse aus Experteninterviews
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Szameitat, Jörg, Dony, Elke, Fausel, Gudrun, and Knapp, Barbara
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Soziale Ungleichheit ,Kulturelle Identität ,ddc:330 ,Diversity Management ,Deutschland ,Soziale Integration - Abstract
Die aktuelle Zuwanderung von Flüchtlingen stellt den deutschen Arbeitsmarkt vor neue Herausforderungen. Ein erhöhtes Ausmaß sozialer Vielfalt, an kultureller Diversität, kommt auf die Betriebe zu. Nicht zuletzt werden deren organisatorische und soziale Kompetenzen gefragt sein, wenn es darum geht, mit neuen Arbeitskräften bisher vielleicht fremder kultureller Herkunft im Arbeitsalltag umzugehen. Dies lenkt neues Augenmerk auf die Rolle von Diversity Management. Dessen ursprüngliches Ziel war es, Chancengleichheit am Arbeitsmarkt zu ermöglichen. Da es soziale Vielfalt als Ressource interpretiert, ist Diversity Management inzwischen (auch) ein Instrument zur Produktivitätssteigerung von Betrieben geworden. Welche Motive für und Arten von Diversity Management sich in deutschen Betrieben tatsächlich finden und wie diese mit Tendenzen sozialer Schließung in Einstellungsprozessen zusammenhängen, beschreibt dieser Bericht auf Basis von Experteninterviews. Den theoretischen Hintergrund bildet dabei der Zusammenhang von Diversität und sozialer Schließung im Betrieb. Die Auswertung der Interviews mündet in einer Aufstellung verschiedener Typen von Betrieben, die sich hinsichtlich ihrer Haltung Diversity Management gegenüber, ihres Motivs dafür, ihres Umgangs mit sozialer Vielfalt sowie ihres Grades an sozialer Schließung unterscheiden. Eine bereits bestehende Typologie von Diversity Management von Thomas und Ely (1996) wird dabei um zwei Typen erweitert. Die Ergebnisse legen nahe, dass eine nachhaltige Nutzung sozialer Vielfalt durch zwei Faktoren begünstigt wird: Eine historisch-politisch oder organisatorisch bedingte Auseinandersetzung mit sozialer Vielfalt einerseits und eine idealistisch motivierte positive Wertschätzung sozialer Vielfalt andererseits. The current migration of refugees will challenge the German labor market in new ways. Firms will be facing a heightened degree of cultural diversity. Having to deal with new employees of probably unknown cultural origin will most likely test firms' organizational and social skills. This puts new emphasis on the task of managing diversity. The initial goal of diversity management was to establish equal chances for minorities in the labor market. Interpreting social diversity as an economic resource has by now (also) rendered diversity management an instrument to increase a firm's productivity. Based on expert interviews in German firms, this report describes the motives for and different kinds of diversity management that can be identified empirically and how they relate to different degrees of social closure in hiring processes. The theoretical backdrop is the connection between diversity and social closure in a firm. Analyzing the interviews results in a typology of firms that differ in attitude towards and motive for diversity management as well as in how they handle diversity and how socially closed they are, and thereby expanding a typology of diversity management by Thomas and Ely (1996) by two types. The results suggest that a sustainable usage of diversity benefits of two factors: A confrontation with diversity brought about by political or historical circumstances on the one hand and an idealistically motivated positive appreciation of diversity on the other.
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- 2016
18. CiliaCarta: an integrated and validated compendium of ciliary genes
- Author
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van Dam, Teunis J. P., primary, Kennedy, Julie, additional, Lee, Robin van der, additional, Vrieze, Erik de, additional, Wunderlich, Kirsten A., additional, Rix, Suzanne, additional, Dougherty, Gerard W., additional, Lambacher, Nils J., additional, Li, Chunmei, additional, Jensen, Victor L., additional, Leroux, Michel R., additional, Hjeij, Rim, additional, Horn, Nicola, additional, Texier, Yves, additional, Wissinger, Yasmin, additional, van Reeuwijk, Jeroen, additional, Wheway, Gabrielle, additional, Knapp, Barbara, additional, Scheel, Jan F., additional, Franco, Brunella, additional, Mans, Dorus A., additional, van Wijk, Erwin, additional, Képès, François, additional, Slaats, Gisela G., additional, Toedt, Grischa, additional, Kremer, Hannie, additional, Omran, Heymut, additional, Szymanska, Katarzyna, additional, Koutroumpas, Konstantinos, additional, Ueffing, Marius, additional, Nguyen, Thanh-Minh T., additional, Letteboer, Stef J.F., additional, Oud, Machteld M., additional, van Beersum, Sylvia E. C., additional, Schmidts, Miriam, additional, Beales, Philip L., additional, Lu, Qianhao, additional, Giles, Rachel H., additional, Szklarczyk, Radek, additional, Russell, Robert B., additional, Gibson, Toby J., additional, Johnson, Colin A., additional, Blacque, Oliver E., additional, Wolfrum, Uwe, additional, Boldt, Karsten, additional, Roepman, Ronald, additional, Hernandez-Hernandez, Victor, additional, and Huynen, Martijn A., additional
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- 2017
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- View/download PDF
19. Early Intervention - Modellprojekt zur frühzeitigen Arbeitsmarktintegration von Asylbewerberinnen und Asylbewerbern : Ergebnisse der qualitativen Begleitforschung
- Author
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Daumann, Volker, Dietz, Martin, Knapp, Barbara, and Strien, Karsten
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Asylbewerber, berufliche Integration, Flüchtlinge, arbeitsmarktpolitische Maßnahme - Modellversuch, Arbeitsvermittler - Einstellungen - Abstract
"Germany is facing an increasing number of persons applying for asylum. The Federal Employment Agency, the Federal Office for Migration and Refugees and XENOS - a program sponsored by the European Social Fund providing labour market related support to refugees - launched a pilot project. This project aims at a quick support with respect to a successful labour market integration that also considers the formal qualification of the asylum seekers in an adequate way. The project was implemented in six German regions and is evaluated by the Institute for Employment Research. The Research Report analysis the implementation of the project within the local agencies and discusses major challenges on a way to find appropriate jobs for the asylum seekers." (Author's abstract, IAB-Doku) ((en))
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- 2015
20. Abschlussbericht Modellprojekt Early Intervention: Frühzeitige Arbeitsmarktintegration von Asylbewerbern und Asylbewerberinnen. Ergebnisse der qualitativen Begleitforschung durch das IAB
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Büschel, Ulrike, Daumann, Volker, Dietz, Martin, Dony, Elke, Knapp, Barbara, and Strien, Karsten
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ddc:330 - Abstract
Die steigende Zahl an Asylbewerbern bringt neue Aufgaben für die Arbeitsmarkt- und Beschäftigungspolitik mit sich. In dem gemeinsamen Modellprojekt 'Early Intervention' nahmen sich die Bundesagentur für Arbeit (BA), das Bundesamt für Migration und Flüchtlinge (BAMF) und das vom Europäischen Sozialfonds (ESF) geförderte Bundesprogramm 'XENOS - Arbeitsmarktliche Unterstützung für Bleibeberechtigte und Flüchtlinge'dieser Herausforderung an und erprobten Wege einer frühzeitigen Arbeitsmarktintegration von Asylbewerbern. Bei dem im Rechtskreis SGB III angelegten Modellprojekt verfolgt man den Ansatz, sich auf die Gruppe der relativ gut qualifizierten Asylbewerber mit einer hohen Bleibewahrscheinlichkeit zu konzentrieren. Das Institut für Arbeitsmarkt- und Berufsforschung (IAB) begleitet die Umsetzung des Modellprojekts seit Einführung im Januar 2014 wissenschaftlich. Hierzu wurden in zwei Wellen Interviews mit verschiedenen Akteuren in den sechs Modellagenturen der ersten Stunde durchgeführt. Im ersten Teil der Evaluation standen Aspekte der Teilnehmergewinnung in Kooperation mit dem BAMF, der Projektzuweisung durch die Modellprojektvermittler und Erfahrungen im Beratungsprozess im Vordergrund. Die Ergebnisse sind im IAB-Forschungsbericht 3/2015 nachzulesen. Die zweite Evaluationsphase, deren Ergebnisse im vorliegenden Forschungsbericht aufgeführt werden, nahm Erfahrungen aus den Integrationsbemühungen, die Zusammenarbeitsstrukturen in den Agenturen sowie die Probleme, die mit einem Rechtskreiswechsel verbunden sind, in den Blick. Germany is facing an increasing number of persons applying for asylum. The Federal Employment Agency, the Federal Office for Migration and Refugees and XENOS - a program sponsored by the European Social Fund providing labour market related support to refugees - launched a pilot project. This project aims at a quick support with respect to a successful labour market integration that also considers the formal qualification of the asylum seekers in an adequate way. The project was implemented in six German regions and is evaluated by the Institute for Employment Research. The Research Report analyses starting points as well as barriers to labour market integration. It discusses the structure of supporting the refugees within the project and points at problems stemming from the fact that the responsibility for counselling activities shifts from case workers in employment agencies to job centers when the application for asylum is approved. These entities are acting under different legal, financial and organizational frameworks. This structure is a severe handicap for implementing a consistent strategy for the labour market integration of asylum seekers.
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- 2015
21. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
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Hamann, Jörg, primary, Aust, Gabriela, additional, Araç, Demet, additional, Engel, Felix B., additional, Formstone, Caroline, additional, Fredriksson, Robert, additional, Hall, Randy A., additional, Harty, Breanne L., additional, Kirchhoff, Christiane, additional, Knapp, Barbara, additional, Krishnan, Arunkumar, additional, Liebscher, Ines, additional, Lin, Hsi-Hsien, additional, Martinelli, David C., additional, Monk, Kelly R., additional, Peeters, Miriam C., additional, Piao, Xianhua, additional, Prömel, Simone, additional, Schöneberg, Torsten, additional, Schwartz, Thue W., additional, Singer, Kathleen, additional, Stacey, Martin, additional, Ushkaryov, Yuri A., additional, Vallon, Mario, additional, Wolfrum, Uwe, additional, Wright, Mathew W., additional, Xu, Lei, additional, Langenhan, Tobias, additional, and Schiöth, Helgi B., additional
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- 2015
- Full Text
- View/download PDF
22. CiliaCarta: An integrated and validated compendium of ciliary genes
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Gerard W. Dougherty, Victor L. Jensen, Jan Frederik Scheel, Katarzyna Szymanska, Uwe Wolfrum, Radek Szklarczyk, Miriam Schmidts, Julie Kennedy, Erwin van Wijk, Brunella Franco, Toby J. Gibson, Machteld M. Oud, Chunmei Li, Nils J. Lambacher, Erik de Vrieze, Grischa Toedt, Teunis J. P. van Dam, Karsten Boldt, Heymut Omran, Yves Texier, Rachel H. Giles, Ronald Roepman, Kirsten A. Wunderlich, Sylvia E. C. van Beersum, Oliver E. Blacque, Thanh-Minh T. Nguyen, Konstantinos Koutroumpas, Hannie Kremer, Nicola Horn, Martijn A. Huynen, Michel R. Leroux, Gabrielle Wheway, Rim Hjeij, Philip L. Beales, Gisela G. Slaats, Robert B. Russell, Robin van der Lee, François Képès, Yasmin Wissinger, Barbara Knapp, Dorus A. Mans, Suzanne Rix, Marius Ueffing, Colin A. Johnson, Stef J.F. Letteboer, Victor Hernandez-Hernandez, Qianhao Lu, Jeroen van Reeuwijk, Sub Bioinformatics, Theoretical Biology and Bioinformatics, MUMC+: DA KG Lab Centraal Lab (9), Klinische Genetica, RS: GROW - R4 - Reproductive and Perinatal Medicine, van Dam, Teunis J P, Kennedy, Julie, van der Lee, Robin, de Vrieze, Erik, Wunderlich, Kirsten A, Rix, Suzanne, Dougherty, Gerard W, Lambacher, Nils J, Li, Chunmei, Jensen, Victor L, Leroux, Michel R, Hjeij, Rim, Horn, Nicola, Texier, Yve, Wissinger, Yasmin, van Reeuwijk, Jeroen, Wheway, Gabrielle, Knapp, Barbara, Scheel, Jan F, Franco, Brunella, Mans, Dorus A, van Wijk, Erwin, Képès, Françoi, Slaats, Gisela G, Toedt, Grischa, Kremer, Hannie, Omran, Heymut, Szymanska, Katarzyna, Koutroumpas, Konstantino, Ueffing, Mariu, Nguyen, Thanh-Minh T, Letteboer, Stef J F, Oud, Machteld M, van Beersum, Sylvia E C, Schmidts, Miriam, Beales, Philip L, Lu, Qianhao, Giles, Rachel H, Szklarczyk, Radek, Russell, Robert B, Gibson, Toby J, Johnson, Colin A, Blacque, Oliver E, Wolfrum, Uwe, Boldt, Karsten, Roepman, Ronald, Hernandez-Hernandez, Victor, and Huynen, Martijn A
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Proteomics ,Sensory Receptors ,Nematoda ,Social Sciences ,Ciliopathies ,Biochemistry ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Transcriptome ,0302 clinical medicine ,Animal Cells ,Psychology ,RETINAL PHOTORECEPTOR CELLS ,Exome ,Neurons ,0303 health sciences ,030302 biochemistry & molecular biology ,Eukaryota ,Genomics ,PRIMARY CILIUM ,thecilium ,3. Good health ,Nucleic acids ,Genetic interference ,Osteichthyes ,Medicine ,Epigenetics ,Cellular Structures and Organelles ,Cellular Types ,proteomic databases ,Sensory Receptor Cells ,Science ,education ,Ciliary genes ,LEBER CONGENITAL AMAUROSIS ,03 medical and health sciences ,Genetics ,Cilia ,Caenorhabditis elegans ,IDENTIFICATION ,MUTATIONS ,Embryos ,cilia ,Organisms ,Biology and Life Sciences ,Bayes Theorem ,Molecular Sequence Annotation ,medicine.disease ,Invertebrates ,Fish ,ciliary proteome ,Animal Studies ,Caenorhabditis ,Gene expression ,embryos ,030217 neurology & neurosurgery ,Developmental Biology ,Neuroscience ,Photoreceptors ,Candidate gene ,Embryology ,Oligonucleotides ,Morpholino ,Database and Informatics Methods ,RNA interference ,Bayesian classifier ,TRANSITION ZONE ,Zebrafish ,Antisense Oligonucleotides ,Multidisciplinary ,Spectrometric Identification of Proteins ,Proteomic Databases ,Nucleotides ,Cilium ,Stable Isotope Labeling by Amino Acids in Cell Culture ,photoreceptors ,Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] ,Animal Models ,Phenotype ,INTRAFLAGELLAR TRANSPORT ,DIFFERENTIATION ,Experimental Organism Systems ,Caenorhabditis Elegans ,Vertebrates ,Sensory Perception ,Research Article ,Signal Transduction ,EXPRESSION ,Stable isotope labeling by amino acids in cell culture ,Computational biology ,Biology ,Research and Analysis Methods ,SOLUTE-CARRIER-PROTEIN ,Model Organisms ,medicine ,Animals ,data integration ,030304 developmental biology ,Afferent Neurons ,Reproducibility of Results ,Cell Biology ,zebrafish ,biology.organism_classification ,Ciliopathy ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,Biological Databases ,Cellular Neuroscience ,RNA ,OSCP1 ,CiliaCarta - Abstract
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliary components remain undiscovered. We generated and rigorously analyzed genomic, proteomic, transcriptomic and evolutionary data and systematically integrated these using Bayesian statistics into a predictive score for ciliary function. This resulted in 285 candidate ciliary genes. We generated independent experimental evidence of ciliary associations for 24 out of 36 analyzed candidate proteins using multiple cell and animal model systems (mouse, zebrafish and nematode) and techniques. For example, we show that OSCP1, which has previously been implicated in two distinct non-ciliary processes, causes ciliogenic and ciliopathy-associated tissue phenotypes when depleted in zebrafish. The candidate list forms the basis of CiliaCarta, a comprehensive ciliary compendium covering 956 genes. The resource can be used to objectively prioritize candidate genes in whole exome or genome sequencing of ciliopathy patients and can be accessed at http://bioinformatics.bio.uu.nl/john/syscilia/ciliacarta/. This work was supported by the European Community’s Seventh Framework Programme [241955, 278568 to MU and KB, 602273 to RS]; the Virgo consortium, funded by the Dutch government [FES0908 to TvD, RvdL and MAH]; the Netherlands Genomics Initiative [050-060-452 to TvD, RvdL and MAH]; the Canadian Institutes of Health Research [MOP-142243, MOP-82870 and PJT-156042 to MRL]; Michael Smith Foundation for Health Research to MRL and VLJ; Kidney Research Scientist Core Education and National Training fellowship to VLJ; The Foundation Fighting Blindness [PPA-0717-0719-RAD to UW, RR, and MU]; the Dutch Kidney Foundation “KOUNCIL” consortium [CP11.18 to RHG, PLB and RR]; The Deutsche Forschungsgemeinschaft [Excellence grant CellNetworks to RBR and QL, CRC1140 “Kidney Disease – From Genes to Mechanisms” to MS, collaborative research center grant SFB-1411 KIDGEM to MS]; Metakids Foundation to RS; the National Institute for Health Research to PLB and VH-H. PLB is an NIHR Senior Investigator; Radboudumc Hypatia Tenure Track Fellowship, Radboud Universiteit excellence fellowship, ERC starting grant TREATCilia, grant agreement no. 716344 to MS; and the Netherlands Organization for Scientific Research [NWO Vici-865.12.005 to RR].
- Published
- 2019
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