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Your search keyword '"Kreiling, Jill A."' showing total 30 results
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30 results on '"Kreiling, Jill A."'

7. Loss of epigenetic information as a cause of mammalian aging

Author

Yang, Jae-Hyun, Hayano, Motoshi, Griffin, Patrick T., Amorim, João A., Bonkowski, Michael S., Apostolides, John K., Salfati, Elias L., Blanchette, Marco, Munding, Elizabeth M., Bhakta, Mital, Chew, Yap Ching, Guo, Wei, Yang, Xiaojing, Maybury-Lewis, Sun, Tian, Xiao, Ross, Jaime M., Coppotelli, Giuseppe, Meer, Margarita V., Rogers-Hammond, Ryan, Vera, Daniel L., Lu, Yuancheng Ryan, Pippin, Jeffrey W., Creswell, Michael L., Dou, Zhixun, Xu, Caiyue, Mitchell, Sarah J., Das, Abhirup, O’Connell, Brendan L., Thakur, Sachin, Kane, Alice E., Su, Qiao, Mohri, Yasuaki, Nishimura, Emi K., Schaevitz, Laura, Garg, Neha, Balta, Ana-Maria, Rego, Meghan A., Gregory-Ksander, Meredith, Jakobs, Tatjana C., Zhong, Lei, Wakimoto, Hiroko, El Andari, Jihad, Grimm, Dirk, Mostoslavsky, Raul, Wagers, Amy J., Tsubota, Kazuo, Bonasera, Stephen J., Palmeira, Carlos M., Seidman, Jonathan G., Seidman, Christine E., Wolf, Norman S., Kreiling, Jill A., Sedivy, John M., Murphy, George F., Green, Richard E., Garcia, Benjamin A., Berger, Shelley L., Oberdoerffer, Philipp, Shankland, Stuart J., Gladyshev, Vadim N., Ksander, Bruce R., Pfenning, Andreas R., Rajman, Luis A., and Sinclair, David A.

Published
2023
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12. Loss of epigenetic information as a cause of mammalian aging

Author

Yang, Jae-Hyun, primary, Hayano, Motoshi, additional, Griffin, Patrick T., additional, Amorim, João A., additional, Bonkowski, Michael S., additional, Apostolides, John K., additional, Salfati, Elias L., additional, Blanchette, Marco, additional, Munding, Elizabeth M., additional, Bhakta, Mital, additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Maybury-Lewis, Sun, additional, Tian, Xiao, additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Meer, Margarita V., additional, Rogers-Hammond, Ryan, additional, Vera, Daniel L., additional, Lu, Yuancheng Ryan, additional, Pippin, Jeffrey W., additional, Creswell, Michael L., additional, Dou, Zhixun, additional, Xu, Caiyue, additional, Mitchell, Sarah J., additional, Das, Abhirup, additional, O’Connell, Brendan L., additional, Thakur, Sachin, additional, Kane, Alice E., additional, Su, Qiao, additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, El Andari, Jihad, additional, Grimm, Dirk, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine E., additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Green, Richard E., additional, Garcia, Benjamin A., additional, Berger, Shelley L., additional, Oberdoerffer, Philipp, additional, Shankland, Stuart J., additional, Gladyshev, Vadim N., additional, Ksander, Bruce R., additional, Pfenning, Andreas R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2024
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22. Sex‐specific aging in animals: Perspective and future directions

Author

Bronikowski, Anne M., primary, Meisel, Richard P., additional, Biga, Peggy R., additional, Walters, James R., additional, Mank, Judith E., additional, Larschan, Erica, additional, Wilkinson, Gerald S., additional, Valenzuela, Nicole, additional, Conard, Ashley Mae, additional, Magalhães, João Pedro, additional, Duan, Jingyue (Ellie), additional, Elias, Amy E., additional, Gamble, Tony, additional, Graze, Rita M., additional, Gribble, Kristin E., additional, Kreiling, Jill A., additional, and Riddle, Nicole C., additional

Published
2022
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23. Loss of Epigenetic Information as a Cause of Mammalian Aging

Author

Yang, Jae-Hyun, primary, Hayano, Motoshi, additional, Griffin, Patrick, additional, Amorim, Joao A., additional, Bonkowski, Michael S., additional, Apostolides, John K., additional, Blanchette, Marco, additional, Munding, Elizabeth M., additional, Bhakta, Mital, additional, Salfati, Elias L., additional, Lu, Yuancheng, additional, Vera, Daniel L., additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Meer, Margarita V., additional, Tian, Xiao, additional, Dou, Zhixun, additional, Xu, Caiyue, additional, Pippin, Jeffrey W., additional, Creswell, Michael, additional, Mitchell, Sarah J., additional, Das, Abhirup, additional, O’Connell, Brendan L., additional, Thakur, Sachin, additional, Kane, Alice E., additional, Su, Qiao, additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine, additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Green, Richard E., additional, Garcia, Benjamin A., additional, Berger, Shelley L., additional, Oberdoerffer, Philipp, additional, Shankland, Stuart J., additional, Gladyshev, Vadim N., additional, Ksander, Bruce R., additional, Pfenning, Andreas R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2021
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25. DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Author

Hayano, Motoshi, primary, Yang, Jae-Hyun, additional, Bonkowski, Michael S., additional, Amorim, Joao A., additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Griffin, Patrick T., additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Vera, Daniel L., additional, Salfati, Elias L., additional, Das, Abhirup, additional, Thakur, Sachin, additional, Kane, Alice E., additional, Mitchell, Sarah J., additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine E., additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Oberdoerffer, Philipp, additional, Ksander, Bruce R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2019
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29. Combining supervised and unsupervised analyses to quantify behavioral phenotypes and validate therapeutic efficacy in a triple transgenic mouse model of Alzheimer's disease.

Author

Del Rosario Hernandez T, Joshi NR, Gore SV, Kreiling JA, and Creton R

Abstract

Behavioral testing is an essential tool for evaluating cognitive function and dysfunction in preclinical research models. This is of special importance in the study of neurological disorders such as Alzheimer's disease. However, the reproducibility of classic behavioral assays is frequently compromised by interstudy variation, leading to ambiguous conclusions about the behavioral markers characterizing the disease. Here, we identify age- and genotype-driven differences between 3xTg-AD and non-transgenic control mice using a low-cost, highly customizable behavioral assay that requires little human intervention. Through behavioral phenotyping combining both supervised and unsupervised behavioral classification methods, we are able to validate the preventative effects of the immunosuppressant cyclosporine A in a rodent model of Alzheimer's disease, as well as the partially ameliorating effects of candidate drugs nebivolol and cabozantinib.

Published
2024
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30. Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral Profiles.

Author

Hernández TDR, Gore SV, Kreiling JA, and Creton R

Abstract

Drug repurposing can accelerate drug development while reducing the cost and risk of toxicity typically associated with de novo drug design. Several disorders lacking pharmacological solutions and exhibiting poor results in clinical trials - such as Alzheimer's disease (AD) - could benefit from a cost-effective approach to finding new therapeutics. We previously developed a neural network model, Z-LaP Tracker, capable of quantifying behaviors in zebrafish larvae relevant to cognitive function, including activity, reactivity, swimming patterns, and optomotor response in the presence of visual and acoustic stimuli. Using this model, we performed a high-throughput screening of FDA-approved drugs to identify compounds that affect zebrafish larval behavior in a manner consistent with the distinct behavior induced by calcineurin inhibitors. Cyclosporine (CsA) and other calcineurin inhibitors have garnered interest for their potential role in the prevention of AD. We generated behavioral profiles suitable for cluster analysis, through which we identified 64 candidate therapeutics for neurodegenerative disorders., Competing Interests: Competing interests Brown University submitted a patent application for the treatment of neurodegenerative disease using CsA-type compounds (application 63/193,935, Robbert Creton - inventor, Sara Tucker Edmister, Rahma Ibrahim, Rohit Kakodkar and Jill A. Kreiling - contributors). The authors declare that they do not have other competing interests.

Published
2023
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