Search

Your search keyword '"Kwon, Hyung-Joon"' showing total 47 results
Start Over Author "Kwon, Hyung-Joon" Publication Year Range Last 10 years
47 results on '"Kwon, Hyung-Joon"'

1. Logical Pseudocode: Connecting Algorithms with Proofs

Author

Kwon, Keehang and Kwon, Hyung Joon

Subjects
Computer Science - Logic in Computer Science
Abstract

Proofs (sequent calculus, natural deduction) and imperative algorithms (pseudocodes) are two well-known coexisting concepts. Then what is their relationship? Our answer is that \[ imperative\ algorithms\ =\ proofs\ with\ cuts \] This observation leads to a generalization to pseudocodes which we call {\it logical pseudocodes}. It is similar to natural deduction proof of computability logic\cite{Jap03,Jap08}. Each statement in it corresponds to a proof step in natural deduction. Therefore, the merit over pseudocode is that each statement is guaranteed to be correct and safe with respect to the initial specifications. It can also be seen as an extension to computability logic web (\colw) with forward reasoning capability., Comment: 4 pages. Induction is missing in version 1 but added in version 2. arXiv admin note: text overlap with arXiv:2108.10728

Published
2022

5. Integrated proteogenomic characterization of glioblastoma evolution

Author

Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, and Park, Jong Bae

Published
2024
Full Text
View/download PDF

6. Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond

Author

Kwon, Hyung-Joon, Kosikova, Martina, Tang, Weichun, Ortega-Rodriguez, Uriel, Radvak, Peter, Xiang, Ruoxuan, Mercer, Kelly E., Muskhelishvili, Levan, Davis, Kelly, Ward, Jerrold M., Kosik, Ivan, Holly, Jaroslav, Kang, Insung, Yewdell, Jonathan W., Plant, Ewan P., Chen, Wilbur H., Shriver, Mallory C., Barnes, Robin S., Pasetti, Marcela F., Zhou, Bin, Wentworth, David E., and Xie, Hang

Published
2022
Full Text
View/download PDF

7. HPK1 Dysregulation‐Associated NK Cell Dysfunction and Defective Expansion Promotes Metastatic Melanoma Progression.

Author

Choi, Woo Seon, Kwon, Hyung‐Joon, Yi, Eunbi, Lee, Haeun, Kim, Jung Min, Park, Hyo Jin, Choi, Eun Ji, Choi, Myoung Eun, Sung, Young Hoon, Won, Chong Hyun, Sung, Chang Ohk, and Kim, Hun Sik

Subjects
*KILLER cells, *IMMUNE checkpoint proteins, *CYTOTOXINS, *TUMOR growth, *IMMUNE response
Abstract

Distant metastasis, the leading cause of cancer death, is efficiently kept in check by immune surveillance. Studies have uncovered peripheral natural killer (NK) cells as key antimetastatic effectors and their dysregulation during metastasis. However, the molecular mechanism governing NK cell dysfunction links to metastasis remains elusive. Herein, MAP4K1 encoding HPK1 is aberrantly overexpressed in dysfunctional NK cells in the periphery and the metastatic site. Conditional HPK1 overexpression in NK cells suffices to exacerbate melanoma lung metastasis but not primary tumor growth. Conversely, MAP4K1‐deficient mice are resistant to metastasis and further protected by combined immune‐checkpoint inhibitors. Mechanistically, HPK1 restrains NK cell cytotoxicity and expansion via activating receptors. Likewise, HPK1 limits human NK cell activation and associates with melanoma NK cell dysfunction couples to TGF‐β1 and patient response to immune checkpoint therapy. Thus, HPK1 is an intracellular checkpoint controlling NK‐target cell responses, which is dysregulated and hijacked by tumors during metastatic progression. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Fam20C Kinase as A Key Regulator of Bevacizumab Resistance in Mesenchymal Glioblastoma

Author

Kim, Chan Il, primary, Kim, Sooheon, additional, Park, Seong‐Min, additional, Kim, Sung Soo, additional, Kwon, Hyung Joon, additional, Lin, Weiwei, additional, Park, Saewhan, additional, Ha, Seokjun, additional, Ha, Kyung Hee, additional, Park, Sanha, additional, Park, Seung Min, additional, Kim, Tae Hoon, additional, Kim, Kyung‐Hee, additional, Kim, Yun‐Hee, additional, Kim, Jong Heon, additional, and Park, Jong Bae, additional

Published
2023
Full Text
View/download PDF

12. Monoclonal Antibodies as SARS-CoV-2 Serology Standards: Experimental Validation and Broader Implications for Correlates of Protection

Author

Wang, Lili, primary, Patrone, Paul N., additional, Kearsley, Anthony J., additional, Izac, Jerilyn R., additional, Gaigalas, Adolfas K., additional, Prostko, John C., additional, Kwon, Hyung Joon, additional, Tang, Weichun, additional, Kosikova, Martina, additional, Xie, Hang, additional, Tian, Linhua, additional, Elsheikh, Elzafir B., additional, Kwee, Edward J., additional, Kemp, Troy, additional, Jochum, Simon, additional, Thornburg, Natalie, additional, McDonald, L. Clifford, additional, Gundlapalli, Adi V., additional, and Lin-Gibson, Sheng, additional

Published
2023
Full Text
View/download PDF

13. CAMEL NANOBODIES NEUTRALIZE SARS-COV-2 VARIANTS

Author

Hong, Jessica, primary, Kwon, Hyung Joon, additional, Cachau, Raul, additional, Butay, Kevin John, additional, Duan, Zhijian, additional, Li, Dan, additional, Ren, Hua, additional, Hsieh, Chao-Ming, additional, Dandey, Venkata P, additional, Borgnia, Mario J, additional, Xie, Hang, additional, and Ho, Mitchell, additional

Published
2023
Full Text
View/download PDF

15. Data from Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Author

Yin, Jinlong, primary, Oh, Young Taek, primary, Kim, Jeong-Yub, primary, Kim, Sung Soo, primary, Choi, Eunji, primary, Kim, Tae Hoon, primary, Hong, Jun Hee, primary, Chang, Nakho, primary, Cho, Hee Jin, primary, Sa, Jason K., primary, Kim, Jeong Cheol, primary, Kwon, Hyung Joon, primary, Park, Saewhan, primary, Lin, Weiwei, primary, Nakano, Ichiro, primary, Gwak, Ho-Shin, primary, Yoo, Heon, primary, Lee, Seung-Hoon, primary, Lee, Jeongwu, primary, Kim, Jong Heon, primary, Kim, Soo-Youl, primary, Nam, Do-Hyun, primary, Park, Myung-Jin, primary, and Park, Jong Bae, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figure 1-3 from Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Author

Yin, Jinlong, primary, Oh, Young Taek, primary, Kim, Jeong-Yub, primary, Kim, Sung Soo, primary, Choi, Eunji, primary, Kim, Tae Hoon, primary, Hong, Jun Hee, primary, Chang, Nakho, primary, Cho, Hee Jin, primary, Sa, Jason K., primary, Kim, Jeong Cheol, primary, Kwon, Hyung Joon, primary, Park, Saewhan, primary, Lin, Weiwei, primary, Nakano, Ichiro, primary, Gwak, Ho-Shin, primary, Yoo, Heon, primary, Lee, Seung-Hoon, primary, Lee, Jeongwu, primary, Kim, Jong Heon, primary, Kim, Soo-Youl, primary, Nam, Do-Hyun, primary, Park, Myung-Jin, primary, and Park, Jong Bae, primary

Published
2023
Full Text
View/download PDF

21. Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

Author

Zhang, Jun, primary, Tang, Weichun, additional, Gao, Hailong, additional, Lavine, Christy L., additional, Shi, Wei, additional, Peng, Hanqin, additional, Zhu, Haisun, additional, Anand, Krishna, additional, Kosikova, Matina, additional, Kwon, Hyung Joon, additional, Tong, Pei, additional, Gautam, Avneesh, additional, Rits-Volloch, Sophia, additional, Wang, Shaowei, additional, Mayer, Megan L., additional, Wesemann, Duane R., additional, Seaman, Michael S., additional, Lu, Jianming, additional, Xiao, Tianshu, additional, Xie, Hang, additional, and Chen, Bing, additional

Published
2022
Full Text
View/download PDF

22. Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

Author

Hong, Jessica, primary, Kwon, Hyung Joon, additional, Cachau, Raul, additional, Chen, Catherine Z., additional, Butay, Kevin John, additional, Duan, Zhijian, additional, Li, Dan, additional, Ren, Hua, additional, Liang, Tianyuzhou, additional, Zhu, Jianghai, additional, Dandey, Venkata P., additional, Martin, Negin P., additional, Esposito, Dominic, additional, Ortega-Rodriguez, Uriel, additional, Xu, Miao, additional, Borgnia, Mario J., additional, Xie, Hang, additional, and Ho, Mitchell, additional

Published
2022
Full Text
View/download PDF

25. Camel nanobodies broadly neutralize SARS-CoV-2 variants

Author

Hong, Jessica, primary, Kwon, Hyung Joon, additional, Cachau, Raul, additional, Chen, Catherine Z., additional, Butay, Kevin John, additional, Duan, Zhijian, additional, Li, Dan, additional, Ren, Hua, additional, Liang, Tianyuzhou, additional, Zhu, Jianghai, additional, Dandey, Venkata P., additional, Martin, Negin, additional, Esposito, Dominic, additional, Ortega-Rodriguez, Uriel, additional, Xu, Miao, additional, Borgnia, Mario J., additional, Xie, Hang, additional, and Ho, Mitchell, additional

Published
2021
Full Text
View/download PDF

28. B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strains

Author

Radvak, Peter, primary, Kwon, Hyung Joon, additional, Kosikova, Martina, additional, Ortega-Rodriguez, Uriel, additional, Xiang, Ruoxuan, additional, Phue, Je-Nie, additional, Shen, Rong-Fong, additional, Rozzelle, James, additional, Kapoor, Neeraj, additional, Rabara, Taylor, additional, Fairman, Jeff, additional, and Xie, Hang, additional

Published
2021
Full Text
View/download PDF

29. SARS-CoV-2 show no infectivity at later stages in a prolonged COVID-19 patient despite positivity in RNA testing

Author

Wan, Xiu-Feng, primary, Tang, Cynthia Y., additional, Ritter, Detlef, additional, Wang, Yang, additional, Li, Tao, additional, Segovia, Karen, additional, Kosikova, Martina, additional, Johnson, Marc, additional, Kwon, Hyung Joon, additional, Xie, Hang, additional, Hammer, Richard D., additional, McElroy, Jane A., additional, Hamid, Aws, additional, Collins, Natalie D, additional, Hang, Jun, additional, and Camp, Simone, additional

Published
2021
Full Text
View/download PDF

30. Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma

Author

Hong, Jun-Hee, primary, Kang, Sangjo, additional, Sa, Jason K, additional, Park, Gunwoo, additional, Oh, Young Taek, additional, Kim, Tae Hoon, additional, Yin, Jinlong, additional, Kim, Sung Soo, additional, D’Angelo, Fulvio, additional, Koo, Harim, additional, You, Yeonhee, additional, Park, Saewhan, additional, Kwon, Hyung Joon, additional, Kim, Chan Il, additional, Ryu, Haseo, additional, Lin, Weiwei, additional, Park, Eun Jung, additional, Kim, Youn-Jae, additional, Park, Myung-Jin, additional, Kim, Hyunggee, additional, Kim, Mi-Suk, additional, Chung, Seok, additional, Park, Chul-Kee, additional, Park, Sung-Hye, additional, Kang, Yun Hee, additional, Kim, Jong Heon, additional, Saya, Hideyuki, additional, Nakano, Ichiro, additional, Gwak, Ho-Shin, additional, Yoo, Heon, additional, Lee, Jeongwu, additional, Hur, Eun-Mi, additional, Shi, Bingyang, additional, Nam, Do-Hyun, additional, Iavarone, Antonio, additional, Lee, Seung-Hoon, additional, and Park, Jong Bae, additional

Published
2021
Full Text
View/download PDF

31. Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell–associated lung inflammation

Author

Hyun, Young-Min, primary, Seo, Sang-Uk, additional, Choi, Woo Seon, additional, Kwon, Hyung-Joon, additional, Kim, Dong-Young, additional, Jeong, Soi, additional, Kang, Gyeong-Yi, additional, Yi, Eunbi, additional, Kim, Minjung, additional, Ryu, Hyun Jin, additional, Looney, Mark R., additional, Choi, Eun Young, additional, and Kim, Hun Sik, additional

Published
2020
Full Text
View/download PDF

33. ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages

Author

Yin, Jinlong, primary, Kim, Sung Soo, additional, Choi, Eunji, additional, Oh, Young Taek, additional, Lin, Weiwei, additional, Kim, Tae-Hoon, additional, Sa, Jason K., additional, Hong, Jun Hee, additional, Park, Se Hwan, additional, Kwon, Hyung Joon, additional, Jin, Xiong, additional, You, Yeonhee, additional, Kim, Ji Hye, additional, Kim, Hyunggee, additional, Son, Jaekyoung, additional, Lee, Jeongwu, additional, Nam, Do-Hyun, additional, Choi, Kui Son, additional, Shi, Bingyang, additional, Gwak, Ho-Shin, additional, Yoo, Heon, additional, Iavarone, Antonio, additional, Kim, Jong Heon, additional, and Park, Jong Bae, additional

Published
2020
Full Text
View/download PDF

38. Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Author

Yin, Jinlong, primary, Oh, Young Taek, additional, Kim, Jeong-Yub, additional, Kim, Sung Soo, additional, Choi, Eunji, additional, Kim, Tae Hoon, additional, Hong, Jun Hee, additional, Chang, Nakho, additional, Cho, Hee Jin, additional, Sa, Jason K., additional, Kim, Jeong Cheol, additional, Kwon, Hyung Joon, additional, Park, Saewhan, additional, Lin, Weiwei, additional, Nakano, Ichiro, additional, Gwak, Ho-Shin, additional, Yoo, Heon, additional, Lee, Seung-Hoon, additional, Lee, Jeongwu, additional, Kim, Jong Heon, additional, Kim, Soo-Youl, additional, Nam, Do-Hyun, additional, Park, Myung-Jin, additional, and Park, Jong Bae, additional

Published
2017
Full Text
View/download PDF

41. NK cell function triggered by multiple activating receptors is negatively regulated by glycogen synthase kinase-3β

Author

Kwon, Hyung-Joon, primary, Kwon, Soon Jae, additional, Lee, Heejae, additional, Park, Hye-Ran, additional, Choi, Go-Eun, additional, Kang, Sang-Wook, additional, Kwon, Seog Woon, additional, Kim, Nacksung, additional, Lee, Soo Young, additional, Ryu, Sangryeol, additional, Kim, Sun Chang, additional, and Kim, Hun Sik, additional

Published
2015
Full Text
View/download PDF

43. Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

Author

Cho, Mi-Hyang, Cho, Kwangmin, Kang, Hoe-Jin, Jeon, Eun-Young, Kim, Hun-Sik, Kwon, Hyung-Joon, Kim, Hong-Mi, Kim, Dong-Hou, and Yoon, Seung-Yong

Abstract

Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades extracellular Aβ fibrils via the lysosomal system. Autophagy is a catabolic process that degrades native cellular components, however, the role of autophagy in Aβ degradation by microglia and its effects on AD are unknown. Here we demonstrate a novel role for autophagy in the clearance of extracellular Aβ fibrils by microglia and in the regulation of the Aβ-induced NLRP3 (NLR family, pyrin domain containing 3) inflammasome using microglia specific atg7knockout mice and cell cultures. We found in microglial cultures that Aβ interacts with MAP1LC3B-II via OPTN/optineurin and is degraded by an autophagic process mediated by the PRKAA1 pathway. We anticipate that enhancing microglial autophagy may be a promising new therapeutic strategy for AD.

Published
2014
Full Text
View/download PDF

44. Suppression of Glioblastoma Stem Cell Potency and Tumor Growth via LRRK2 Inhibition.

Author

Park S, Kim KH, Bae YH, Oh YT, Shin H, Kwon HJ, Kim CI, Kim SS, Choi HG, Park JB, and Lee BD

Abstract

Leucine-rich repeat kinase 2 (LRRK2), a large GTP-regulated serine/threonine kinase, is well-known for its mutations causing late-onset Parkinson's disease. However, the role of LRRK2 in glioblastoma (GBM) carcinogenesis has not yet been fully elucidated. Here, we discovered that LRRK2 was overexpressed in 40% of GBM patients, according to tissue microarray analysis, and high LRRK2 expression correlated with poor prognosis in GBM patients. LRRK2 and stemness factors were highly expressed in various patient-derived GBM stem cells, which are responsible for GBM initiation. Canonical serum-induced differentiation decreased the expression of both LRRK2 and stemness factors. Given that LRRK2 is a key regulator of glioma stem cell (GSC) stemness, we developed DNK72, a novel LRRK2 kinase inhibitor that penetrates the blood-brain barrier. DNK72 binds to the phosphorylation sites of active LRRK2 and dramatically reduced cell proliferation and stemness factors expression in in vitro studies. Orthotopic patient-derived xenograft mouse models demonstrated that LRRK2 inhibition with DNK72 effectively reduced tumor growth and increased survival time. We propose that LRRK2 plays a significant role in regulating the stemness of GSCs and that suppression of LRRK2 kinase activity leads to reduced GBM malignancy and proliferation. In the near future, targeting LRRK2 in patients with high LRRK2-expressing GBM could offer a superior therapeutic strategy and potentially replace current clinical treatment methods.

Published
2024
Full Text
View/download PDF

45. Identification of nurse shark V NAR single-domain antibodies targeting the spike S2 subunit of SARS-CoV-2.

Author

Buffington J, Duan Z, Kwon HJ, Hong J, Li D, Feng M, Xie H, and Ho M

Subjects
Humans, SARS-CoV-2, Pandemics, Antibodies, Antibodies, Viral, Antibodies, Neutralizing, COVID-19, Single-Domain Antibodies, Bacteriophages
Abstract

SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Antibody-based therapeutics targeting the spike protein, specifically the S1 subunit or the receptor binding domain (RBD) of SARS-CoV-2, have gained attention due to their clinical efficacy in treating patients diagnosed with COVID-19. An alternative to conventional antibody therapeutics is the use of shark new antigen variable receptor domain (V NAR ) antibodies. V NAR s are small (<15 kDa) and can reach deep into the pockets or grooves of the target antigen. Here, we have isolated 53 V NAR s that bind to the S2 subunit by phage panning from a naïve nurse shark V NAR phage display library constructed in our laboratory. Among those binders, S2A9 showed the best neutralization activity against the original pseudotyped SARS-CoV-2 virus. Several binders, including S2A9, showed cross-reactivity against S2 subunits from other β coronaviruses. Furthermore, S2A9 showed neutralization activity against all variants of concern (VOCs) from alpha to omicron (including BA1, BA2, BA4, and BA5) in both pseudovirus and live virus neutralization assays. Our findings suggest that S2A9 could be a promising lead molecule for the development of broadly neutralizing antibodies against SARS-CoV-2 and emerging variants. The nurse shark V NAR phage library offers a novel platform that can be used to rapidly isolate single-domain antibodies against emerging viral pathogens., (Published 2023. This article is a U.S. Government work and is in the public domain in the USA. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)

Published
2023
Full Text
View/download PDF

46. Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike.

Author

Zhang J, Tang W, Gao H, Lavine CL, Shi W, Peng H, Zhu H, Anand K, Kosikova M, Kwon HJ, Tong P, Gautam A, Rits-Volloch S, Wang S, Mayer ML, Wesemann DR, Seaman MS, Lu J, Xiao T, Xie H, and Chen B

Abstract

The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many countries. We have characterized structural, functional and antigenic properties of the full-length BA.2 spike (S) protein and compared replication of the authentic virus in cell culture and animal model with previously prevalent variants. BA.2 S can fuse membranes more efficiently than Omicron BA.1, mainly due to lack of a BA.1-specific mutation that may retard the receptor engagement, but still less efficiently than other variants. Both BA.1 and BA.2 viruses replicated substantially faster in animal lungs than the early G614 (B.1) strain in the absence of pre-existing immunity, possibly explaining the increased transmissibility despite their functionally compromised spikes. As in BA.1, mutations in the BA.2 S remodel its antigenic surfaces leading to strong resistance to neutralizing antibodies. These results suggest that both immune evasion and replicative advantage may contribute to the heightened transmissibility for the Omicron subvariants.

Published
2022
Full Text
View/download PDF

47. Camel nanobodies broadly neutralize SARS-CoV-2 variants.

Author

Hong J, Kwon HJ, Cachau R, Chen CZ, Butay KJ, Duan Z, Li D, Ren H, Liang T, Zhu J, Dandey VP, Martin N, Esposito D, Ortega-Rodriguez U, Xu M, Borgnia MJ, Xie H, and Ho M

Abstract

With the emergence of SARS-CoV-2 variants, there is urgent need to develop broadly neutralizing antibodies. Here, we isolate two V H H nanobodies (7A3 and 8A2) from dromedary camels by phage display, which have high affinity for the receptor-binding domain (RBD) and broad neutralization activities against SARS-CoV-2 and its emerging variants. Cryo-EM complex structures reveal that 8A2 binds the RBD in its up mode and 7A3 inhibits receptor binding by uniquely targeting a highly conserved and deeply buried site in the spike regardless of the RBD conformational state. 7A3 at a dose of ≥5 mg/kg efficiently protects K18-hACE2 transgenic mice from the lethal challenge of B.1.351 or B.1.617.2, suggesting that the nanobody has promising therapeutic potentials to curb the COVID-19 surge with emerging SARS-CoV-2 variants., One-Sentence Summary: Dromedary camel ( Camelus dromedarius ) V H H phage libraries were built for isolation of the nanobodies that broadly neutralize SARS-CoV-2 variants.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results