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We introduce a green approach to obtain glucose and low-molecular-weight saccharides directly from the cellulose aggregate by using near- and mid-infrared free electron lasers (IR-FELs). The IR-FEL...

A coupling device, which can extract coherent edge radiation (CER) from an optical cavity for a free-electron laser (FEL) without damaging the FEL due to diffraction loss, was developed at Nihon University. We successfully observed the CER beam with a power of 1 mW or more in the terahertz range during FEL oscillation. It is revealed that the CER power changed with the detuning of the optical cavity and the dependence of the CER power on the detuning length differs from that of the FEL power. The measured CER spectra indicate that the longitudinal electron distribution in a bunch is modulated by the FEL oscillation with a period corresponding to the FEL slippage length. We herein report the characteristics of the CER with FEL oscillation in detail. These results demonstrate that the CER is excellent tool to reveal the overall effect of FEL interaction on electron distribution in a bunch.

The X-ray source based on parametric X-ray radiation (PXR) has been regularly providing a coherent X-ray beam for application studies at Nihon University. Recently, three dimensional (3D) computed tomography (CT) has become one of the most important applications of the PXR source. The methodology referred to as K-edge subtraction (KES) imaging is a particularly successful application utilizing the energy selectivity of PXR. In order to demonstrate the applicability of PXR-KES, a simultaneous KES experiment for a specimen containing strontium was performed using a PXR beam having an energy near the Sr K-edge of 16.1 keV. As a result, the 3D distribution of Sr was obtained by subtraction between the two simultaneously acquired tomographic images.

We developed a novel method for element detection utilizing an x-ray source based on parametric x-ray radiation (PXR), an accelerator-based light source at the Laboratory for Electron Beam Research and Application (LEBRA), Nihon University. The method is a type of $K$-edge subtraction (KES) imaging that uses the drastic change of x-ray absorption around the $K$-shell absorption edge of the target element. Using the properties of PXR, simultaneous KES imaging is possible, and can easily be applied to 3-dimensional (3D) computed tomography (CT). We demonstrated the feasibility of simultaneous KES-CT in our previous work. In this study, we investigate the quantitative performance of simultaneous KES imaging for a sample containing the element strontium (Sr) for which the $K$-edge energy is 16.1 keV. Results of a simultaneous KES-CT experiment employing the LEBRA-PXR source confirm that the imaging method can provide a 3D distribution of the element with a value proportional to the Sr concentration. Concerning sensitivity to element concentration, at least in the region of 0.5%-concentration, the sample was successfully distinguished from the region without Sr in the 3D tomographic image obtained using the element-imaging technique.

Development of THz wave source has been underway at Nihon University in collaboration with National Institute of Advanced Industrial Science and Technology. The THz wave transport lines have been constructed on the same axis as the X-ray and FEL beam line. The average intensity of the backward THz CTR wave obtained at the output port of the Parametric Xray Radiation beam line in the accelerator room has been 1 mJ/macro-pulse. The superposition transport system of the THz waves to the X-ray beam-line was installed in a vacuum chamber. Additionally, the energy of the CER as high as 0.2 mJ/macro-pulse were achieved with the experimental room.

Nihon University and National Institute of Advanced Industrial Science and Technology have planned to develop an intense terahertz-wave (THz-wave) source based on coherent Cherenkov radiation (CCR) at Laboratory for Electron Beam Research and Application (LEBRA) in Nihon University. By passing an electron beam through a hollow conical dielectric with apex facing the incident electron beam, the wave front of CCR generated on the inner surface of the hollow conical dielectric is matched to the basal plane. The CCR matched to a circle plane wave is more powerful than conventional THz-wave sources based on electron accelerators. A hollow conical high-resistance silicon with a diameter of the basal plane of 40 mm and an inner diameter of 6 mm will emit the THz-wave beam with a macropulse energy of 14 mJ at LEBRA.

We study the effect of a combination of velocity bunchings and its application to THz coherent undulator radiation at LEBRA, Nihon U. by simulations. The velocity bunching is a technique that is commonly used to make the bunch length shorter at lower energies. However, since one velocity bunching has a correlation between bunch energy and length, we may not have so much room to change energies to obtain different coherent radiation wavelengths. Hence we propose a combination of velocity bunchings, that relaxes the restrictive correlation. We have three 4m traveling-wave accelerator tubes at LEBRA, Nihon U. The undulator is installed after the acceleration tubes and 2 x 45 degree bending magnets. Since the design of current undulator requires less than 25 MeV beam energy to obtain the radiation at THz region, the velocity bunching is reasonable for coherent radiation. We show the simulation results of a combination of velocity bunchings of the three tubes and the magnetic bunching at bending magnets, suitable for the coherent undulator radiation., Proceedings of the 9th Int. Particle Accelerator Conf., IPAC2018, Vancouver, BC, Canada

We propose a high-peak-power terahertz-wave source based on an electron accelerator. By passing an electron beam through a hollow conical dielectric with apex facing the incident electron beam, the wave front of coherent Cherenkov radiation generated on the inner surface of the hollow conical dielectric matches the basal plane. Using the electron beam generated at the Laboratory for Electron Beam Research and Application at Nihon University, the calculated power of coherent Cherenkov radiation that matched the circular plane (CCR-MCP) was above 1 MW per micropulse with a short interval of 350 ps, for wavelengths ranging from 0.5 to 5 mm. The electron beam is not lost for generating the CCR-MCP beam by using the hollow conical dielectric. It is possible to combine the CCR-MCP beams with other light sources based on an accelerator.

Element-sensitive computed tomography (CT) experiments were carried out based on the absorption edge of a specific element using a finely tunable X-ray beam generated by parametric X-ray radiation (PXR). Tomographic images of specimens containing strontium were measured at energies both lower and higher than that of the Sr absorption edge. The difference between the images of the two energies successfully reveals the three-dimensional distributions of Sr. The results demonstrate that this method is effective for elemental analysis of considerably thick samples and could complement X-ray fluorescence analysis.

Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic adverse drug reaction. Previous studies showed that DIHS is associated with the onset of fulminant type 1 diabetes mellitus (FT1D). Although genetic background and abnormalities in immune response or viral infection are considered to be associated with pathogenesis of FT1D, it remains unclear whether virus infection and specific human leukocyte antigen (HLA) typing are involved in DIHS-associated FT1D. Here, we report a case of a 78-year-old female patient with FT1D after DIHS treatment. She was diagnosed as DIHS caused by carbamazepine, and treatment with predonisolone was initiated. After 46 days from the occurrence of DIHS, she was admitted to our hospital because of type 1 diabetes mellitus and diabetic ketoacidosis. Although her Hemoglobin A1c (HbA1c) was elevated by predonisolone treatment (HbA1c: 9.2%), we diagnosed her as fulminant type 1 diabetes mellitus considering the abrupt onset of the ketoacidosis. Her general condition was improved by treatment with fluid infusion and insulin administration. During her clinical course, the infection of coxsackie B4 virus was observed. In addition, the examination of HLA typing showed HLA-A24 haplotype. These findings suggest that the coxsackie B4 virus infection may be involved in the pathogenesis of DIHS-induced FT1D, and that HLA-A24 haplotype might relate to DIHS-associated FT1D.

In the application of lasers in dentistry, there is a delicate balance between the benefits gained from laser treatment and the heat-related damage arising from laser irradiation. Hence, it is necessary to understand the different processes associated with the irradiation of lasers on dental materials. To obtain insight for the development of a safe and general-purpose laser for dentistry, the present study examines the physical effects associated with the irradiation of a near-infrared free-electron laser (FEL) on the surface of a commonly used silver dental alloy. The irradiation experiments using a 2900-nm FEL confirmed the formation of a pit in the dental alloy. The pit was formed with one macro-pulse of FEL irradiation, therefore, suggesting the possibility of efficient material processing with an FEL. Additionally, there was only a slight increase in the silver alloy temperature (less than 0.9 °C) despite the long duration of FEL irradiation, thus inferring that fixed prostheses in the oral cavity can be processed by FEL without thermal damage to the surrounding tissue. These results indicate that dental hard tissues and dental materials in the oral cavity can be safely and efficiently processed by the irradiation of a laser, which has the high repetition rate of a femtosecond laser pulse with a wavelength around 2900 nm.

We developed an intense coherent transition radiation (CTR) at the Laboratory for Electron Beam Research and Application (LEBRA) in Nihon University. A rectangular titanium screen with dimensions of 80 × 60 mm2 was used as the target, and the backward CTR generated on the screen was extracted through a crystal quartz window to air. We observed an intense terahertz (THz) radiation and confirmed it to be the CTR by measuring the spatial distribution and the dependence of the power on the electron charge. The CTR spectrum measured using a Martin–Puplett-type interferometer showed a maximum at a frequency of 0.3 THz and was emitted up to 1.6 THz. The CTR energy and peak power of a micropulse were approximately 80 nJ and 100 kW, respectively. The CTR energy during a 4.5 µs macropulse was approximately 1 mJ, indicating that this broadband THz light source is one of the most powerful coherent radiation sources in normal conducting linac facilities.

A new project to develop a terahertz (THz)-wave light source is in progress at the parametric X-ray (PXR) beamline of the Laboratory for Electron Beam Research and Application (LEBRA) at Nihon University. The THz-wave source is based on coherent transition radiation (CTR) emitted from a metal foil inserted downstream from a crystal target that is the PXR radiator. Beryllium or titanium foil is the most promising candidate for a THz-wave radiator. Since the electron linac of LEBRA was developed for a free electron laser (FEL), electron beam with bunch length of 1 ps (rms) can be provided by magnetic bunching at the bending magnet section. Thus, very intense coherent transition radiation (CTR) can be obtained in the frequency region around 1 THz. The results of preliminary experiments for CTR production suggested that sufficiently intense THz-CTR can be obtained using the LEBRA linac. In order to realize a THz-wave source for practical application studies, we have a plan to add the extraction feature for THz waves to the PXR beamline.