Search

Your search keyword '"López-Varea, Ana"' showing total 11 results
Start Over Author "López-Varea, Ana" Publication Year Range Last 10 years
11 results on '"López-Varea, Ana"'

5. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters

Author

López-Varea, Ana, primary, Ostalé, Cristina M, additional, Vega-Cuesta, Patricia, additional, Ruiz-Gómez, Ana, additional, Organista, María F, additional, Martín, Mercedes, additional, Hevia, Covadonga F, additional, Molnar, Cristina, additional, de Celis, Jesús, additional, Culi, Joaquim, additional, Esteban, Nuria, additional, and de Celis, Jose F, additional

Published
2021
Full Text
View/download PDF

7. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Author

López-Varea, Ana, primary, Vega-Cuesta, Patricia, additional, Ruiz-Gómez, Ana, additional, Ostalé, Cristina M, additional, Molnar, Cristina, additional, Hevia, Covadonga F, additional, Martín, Mercedes, additional, Organista, Maria F, additional, de Celis, Jesus, additional, Culí, Joaquín, additional, Esteban, Nuria, additional, and de Celis, Jose F, additional

Published
2021
Full Text
View/download PDF

11. Developmental analysis of Spalt function in the Drosophila ring gland.

Author

Ostalé CM, Pulido D, Vega-Cuesta P, López-Varea A, and de Celis JF

Abstract

The Spalt transcriptional regulators participate in a variety of cell fate specification processes during development, regulating transcription through interactions with DNA AT-rich regions. Spalt proteins also bind to heterochromatic regions, and some of their effects require interactions with the NuRD chromatin remodeling and deacetylase complex. Most of the biological roles of Spalt proteins have been characterized in diploid cells engaged in cell proliferation. Here we address the function of Drosophila spalt genes in the development of a larval tissue formed by polyploid cells, the prothoracic gland, whose cells undergo several rounds of DNA replication without mitosis during larval development. We show that prothoracic glands depleted of spalt expression display severe changes in the size of the nucleolus, the morphology of the nuclear envelope and the disposition of the chromatin within the nucleus, leading to a failure in the synthesis of ecdysone. We propose that loss of ecdysone production in the prothoracic gland of spalt mutants is primarily caused by defects in nuclear pore complex function that occur as a consequence of faulty interactions between heterochromatic regions and the nuclear envelop., (© 2024. Published by The Company of Biologists Ltd.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results