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Analyzing the effects of space weather on aviation is a new and developing topic. It has been commonly accepted that the flight time of the polar flights may increase during solar proton events because the flights have to change their route to avoid the high-energy particles. However, apart from such phenomenon, researches related to the flight time during space weather events is very rare. Based on the analyses of 39 representative international air routes around westerlies, it is found that 97.44% (94.87%) of the commercial airplanes on the westbound (eastbound) air routes reveal shorter (longer) flight time during solar proton events compared to those during quiet periods, and the averaged magnitude of change in flight time is ~10 min or 0.21%-4.17% of the total flight durations. Comparative investigations reassure the certainty of such phenomenon that the directional differences in flight time are still incontrovertible regardless of over-land routes (China-Europe) or over-sea routes (China-Western America). Further analyses suggest that the solar proton events associated atmospheric heating will change the flight durations by weakening certain atmospheric circulations, such as the polar jet stream. While the polar jet stream will not be obviously altered during solar flares so that the directional differences in flight time are not found. Besides the conventional space weather effects already known, this paper is the first report that indicates a distinct new scenario of how the solar proton events affect flight time. These analyses are also important for aviation since our discoveries could help the airways optimize the air routes to save passenger time costs, reduce fuel costs and even contribute to the global warming issues., submitted to Scientific Reports

To explore the efficacy and value of personalized surgical schemes in the repair of maxillary sinus perforation and maxillary sinus fistula based on the size of the maxillary sinus perforation and maxillary sinus fistula. A total of 28 patients with maxillary sinus perforation and maxillary sinus fistula who were admitted to the Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Kunming Medical University from July 2017 to May 2020 were included to conduct a prospective case clinical study. After the inflammation in the maxillary sinus was controlled, a proper surgical repair method was selected according to the size of the perforation and fistula based on the double-layer closure technique. The diameter of the perforation and fistula was measured with the assistance of cone-beam CT. After that, the platelet rich fibrin (PRF) repair was performed on the perforation and fistula with 3 mm≤diameter7 mm in size in 14 patients. The PRF repair and buccal flap repair were performed on the perforation and fistula with 7 mm ≤diameter15 mm in size in 7 patients. The adjacent buccal pad repair, palatine flap repair, and buccal flap repair were performed on the perforation and fistula with 15 mm≤ diameter25 mm in size in 4 patients. The nasolabial axial flap repair and nasolabial free flap repair were performed on the perforation and fistula with a diameter ≥25 mm in size in 3 patients. The medical follow-up was conducted in all patients in the 1st, 2nd, and 4th week after surgery, with an overall success rate reaching 96.4% (27/28) after the initial intervention. The relapse of disease occurred in one patient (4.6%) with diabetes and a smoking history in the 2nd week after surgery. Identifying a proper surgical repair method according to the size of the oral and maxillary sinus perforation and maxillary sinus fistula based on the double-layer closure technique can improve the one-time cure rate in these patients under the premise that the inflammation in the maxillary sinus can be controlled.根据患者上颌窦穿孔及上颌窦瘘孔大小，选择个性化手术方案，探索在口腔上颌窦穿孔及上颌窦瘘修复中的应用疗效和意义。纳入2017年7月至2020年5月就诊于昆明医科大学附属口腔医院口腔颌面外科的口腔上颌窦穿孔及上颌窦瘘患者28例，进行前瞻性病例临床研究。在保证上颌窦内炎症得以控制的情况下，以双层封闭技术为核心，根据穿孔及瘘孔的大小选择相应的手术修复方法。通过锥形束CT测量穿孔和瘘孔直径大小，对直径≥3 mm且7 mm的14例患者，采用富血小板纤维蛋白（platelet rich fibrin，PRF）填充修复法；对直径≥7 mm且15 mm 的7例患者，采用PRF+颊侧组织瓣修复方法；对直径≥15 mm且25 mm的4例患者，采用邻位颊脂垫组织瓣+腭侧组织瓣+颊侧组织瓣重叠修复法；对直径≥25 mm的3例患者，采用鼻唇沟轴型皮瓣或鼻唇沟任意皮瓣修复法。所有患者在术后第1、2、4周随访检查，初次干预后总成功率为96.4%（27/28）；1例（4.6%）患者术后第2周复发。在保证上颌窦内炎症得以控制的情况下，以双层封闭技术为核心，根据穿孔及瘘孔的大小程度选择相应的手术修复方法，可提高口腔与上颌窦穿孔及上颌窦瘘的一次性治愈率。.

On May 13, 2022, World Health Organization(WHO) Position Paper on Influenza Vaccine (2022 edition) was published. This position paper updates information on influenza epidemiology, high risk population, the impact of immunization on disease, influenza vaccines and effectiveness and safety, and propose WHO's position and recommendation that all countries should consider implementing seasonal influenza vaccine immunization programmes to prepare for an influenza pandemic. In addition, it proposes that the influenza surveillance platform can be integrated with the surveillance of other respiratory viruses, such as SARS-CoV-2 and Respiratory Syncytial Virus. This position paper has some implications for the prevention and control of influenza and other respiratory infectious diseases in China: (1) Optimize influenza vaccine policies to facilitate the implementation of immunization services; (2) Influenza prevention and control should from the perspective of Population Medicine focus on the individual and community to integrate with "Promotion, Prevention, Diagnosis, Control, Treatment, Rehabilitation"; (3) Incorporate prevention and control of other respiratory infectious diseases such as influenza, COVID-19, respiratory syncytial virus and adenovirus, and intelligently monitor by integrating multi-channel data to achieve the goal of co-prevention and control of multiple diseases.2022年5月13日，《世界卫生组织流感疫苗立场文件（2022年版）》（以下简称立场文件）发布。本文总结了立场文件更新的主要内容，包括流感流行病学、风险人群、免疫接种对疾病的影响、流感疫苗及其效果与安全性，世界卫生组织的立场等，推荐各国均应考虑实施流感疫苗免疫规划项目以应对流感大流行。此外，还提出流感监测平台可与新型冠状病毒、呼吸道合胞病毒等其他呼吸道病毒监测整合。分析了对我国流感等呼吸道传染病防控和疫苗接种的启示：（1）优化流感疫苗政策，以促进免疫服务的实施；（2）流感防控应从群医学角度，关注个体和群体“促防诊控治康”一体化；（3）应将流感、新冠、呼吸道合胞病毒、腺病毒等呼吸道传染病联合防控，整合利用多渠道数据，建立多渠道监测和智慧化预警技术和平台，实现多病共防共控。.

A novel electromagnetic bandgap (EBG) power plane etched with multiring complementary split ring resonators (CSRRs) is proposed for effectively suppressing simultaneous switching noise. Its equivalent circuit model is derived for predicting its bandwidth numerically. The measured insertion losses, i.e., S21-parameters of the two fabricated samples agree well with the simulated ones obtained by using the commercial software HFSS, respectively. It is shown that –40 dB suppression is achieved over an ultrawideband from 600 MHz to 13.26 GHz, when the two-ring CSRRs EBG power plane is used. While for four-ring CSRRs EBG case, the suppression level can be extended to –60 dB. Comparative studies are also performed on the signal integrity of a pair of differential transmission lines over L-bridge EBG with and without CSRRs, respectively, and similar performance is achieved.

Sinus floor elevation was needed in 11 patients having 15 implant sites with the residual bone height (RBH) was less than 10 mm in the posterior maxillary region from Feb to May 2017. The RBH ranged from 3.10 to 8.34 mm [averaged (6.18±1.60) mm]. RBH6 mm was observed in 40% implant sites (6 implant sites) and RBH≥6 mm was observed in 60% implant sites (9 implant sites). The thickness of the sinus floor membrane correspond to the implant site measured by cone beam CT (CBCT) ranged from 0.50 to 4.24 mm [averaged (1.21±0.92) mm]. Sequential drills with stops were used to perforate the cortical bone of the sinus floor firstly, then the transcrestal around detached sinus floor elevation technique (TADSFET) was carried with osteotomes. Anorganic bovine bone was used as the augmentation material.Fifteen implants were placed in 15 implant sites. CBCT pictures showed that there was a smooth and continuous tent-shaped apophysis on each lifted site and no air fluid level was observed in the sinus immediately after operation. The mean elevated height of the 15 implant sites was (7.83±1.57) mm (ranged from 5.94 to 11.01 mm). The mean follow-up time was 7.91 months (7-10 months). The survival rate was 100% during the follow up period.纳入2017年2月至5月于清华大学附属垂杨柳医院口腔科就诊的11例上颌后牙缺失患者（15个种植位点），术前锥形束CT测量剩余骨高度（residual bone height，RBH）10 mm，需行上颌窦底提升术。术前RBH为（6.18±1.60）mm [（3.10~8.34）mm]，其中6个位点RBH6 mm，9个位点RBH≥6 mm。种植位点对应上颌窦底黏膜厚度（1.21±0.92）mm [（0.50~4.24）mm]。15个种植位点均应用带止动环序列钻逐级备洞磨穿上颌窦底骨皮质后用新型骨凿行穿牙槽嵴顶四周剥离上颌窦底提升术，术中植入无机牛骨基质及种植体15枚。术后即刻拍摄锥形束CT显示所有上颌窦底提升种植位点区域均形成一外形连续界限清晰的"帐篷状"隆起，上颌窦内均未见异常液平面。上颌窦底提升高度（7.83±1.57）mm [（5.94~11.01）mm]。随访7~10个月，随访期间所有种植体均存留无松动脱落。.

This paper presents a model of double-ring type grounding pole unequal depth embedding for high-voltage direct current (HVDC) transmission system; and introduces calculation formula of DC ground potential distribution when double-ring type grounding pole is unequal buried. Furthermore the ground potential distribution and stride voltage level around the grounding pole and influence of grounding depth and soil parameters on the current field are discussed in this paper. The electric field zoning model of the ring current source is established by using the power system grounding pole analysis software CDEGS to verify the feasibility of this method. As the model is able to make the grounding current overflow density and potential distribution as uniform as possible, there is no serious local current concentration.

Visceral hypersensitivity is enhanced in irritable bowel syndrome (IBS) patients. Treatment of IBS visceral pain by moxibustion methods has a long history and rich clinical experience. In the clinic, moxibustion on the Tianshu (ST25) and Shangjuxu (ST37) acupoints can effectively treat bowel disease with visceral pain and diarrhea symptoms. To investigate the regulatory function of moxibustion on the Tianshu (ST25) and Shangjuxu (ST37) acupoints on spinal cord NR1, NR2B, and PKCεprotein and mRNA expression in irritable bowel syndrome (IBS) visceral hypersensitivity rats, we did some research. In the study, we found that moxibustion effectively relieved the IBS visceral hyperalgesia status of rats. Analgesic effect of moxibustion was similar to intrathecal injection of Ro 25-6981. The expression of NR1, NR2B, and PKCεin the spinal dorsal horns of IBS visceral hyperalgesia rats increased. Moxibustion on the Tianshu and Shangjuxu acupoints might inhibit the visceral hypersensitivity, simultaneously decreasing the expression of NR1, NR2B, and PKCεin spinal cord of IBS visceral hyperalgesia rats. Based on the above experimental results, we hypothesized NR1, NR2B, and PKCεof spinal cord could play an important role in moxibustion inhibiting the process of central sensitization and visceral hyperalgesia state.