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372 results on '"Lee, Kwangho"'

1. Chupa: Carving 3D Clothed Humans from Skinned Shape Priors using 2D Diffusion Probabilistic Models

Author

Kim, Byungjun, Kwon, Patrick, Lee, Kwangho, Lee, Myunggi, Han, Sookwan, Kim, Daesik, and Joo, Hanbyul

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

We propose a 3D generation pipeline that uses diffusion models to generate realistic human digital avatars. Due to the wide variety of human identities, poses, and stochastic details, the generation of 3D human meshes has been a challenging problem. To address this, we decompose the problem into 2D normal map generation and normal map-based 3D reconstruction. Specifically, we first simultaneously generate realistic normal maps for the front and backside of a clothed human, dubbed dual normal maps, using a pose-conditional diffusion model. For 3D reconstruction, we "carve" the prior SMPL-X mesh to a detailed 3D mesh according to the normal maps through mesh optimization. To further enhance the high-frequency details, we present a diffusion resampling scheme on both body and facial regions, thus encouraging the generation of realistic digital avatars. We also seamlessly incorporate a recent text-to-image diffusion model to support text-based human identity control. Our method, namely, Chupa, is capable of generating realistic 3D clothed humans with better perceptual quality and identity variety., Comment: Project Page: https://snuvclab.github.io/chupa/

Published
2023

2. LPMM: Intuitive Pose Control for Neural Talking-Head Model via Landmark-Parameter Morphable Model

Author

Lee, Kwangho, Kwon, Patrick, Lee, Myung Ki, Ahn, Namhyuk, and Lee, Junsoo

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

While current talking head models are capable of generating photorealistic talking head videos, they provide limited pose controllability. Most methods require specific video sequences that should exactly contain the head pose desired, being far from user-friendly pose control. Three-dimensional morphable models (3DMM) offer semantic pose control, but they fail to capture certain expressions. We present a novel method that utilizes parametric control of head orientation and facial expression over a pre-trained neural-talking head model. To enable this, we introduce a landmark-parameter morphable model (LPMM), which offers control over the facial landmark domain through a set of semantic parameters. Using LPMM, it is possible to adjust specific head pose factors, without distorting other facial attributes. The results show our approach provides intuitive rig-like control over neural talking head models, allowing both parameter and image-based inputs.

Published
2023

3. Cross-Domain Style Mixing for Face Cartoonization

Author

Kim, Seungkwon, Gwak, Chaeheon, Kim, Dohyun, Lee, Kwangho, Back, Jihye, Ahn, Namhyuk, and Kim, Daesik

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Cartoon domain has recently gained increasing popularity. Previous studies have attempted quality portrait stylization into the cartoon domain; however, this poses a great challenge since they have not properly addressed the critical constraints, such as requiring a large number of training images or the lack of support for abstract cartoon faces. Recently, a layer swapping method has been used for stylization requiring only a limited number of training images; however, its use cases are still narrow as it inherits the remaining issues. In this paper, we propose a novel method called Cross-domain Style mixing, which combines two latent codes from two different domains. Our method effectively stylizes faces into multiple cartoon characters at various face abstraction levels using only a single generator without even using a large number of training images.

Published
2022

5. Investigating Language Learning Strategies in English Conversation Using Non-Hierarchical Cluster Analysis

Author

Wright, Jocelyn, Ahn, Young-Ho, and Lee, KwangHo

Abstract

This paper on language learner strategies utilizes a little used quantitative, datamining technique called cluster analysis to investigate characteristics of groups of South Korean learners of English. After 71 students in three first-year university liberal arts English conversation courses completed the Strategy Inventory for Language Learning (SILL), and the number of learning strategies was reduced from 50 to 26 based on standard deviation (SD) results, the non-hierarchical (K-means) 3-cluster procedure was applied to the self-reported data. Following statistical analysis, each of the three cluster groups could be profiled according to achievement scores. At this point, six items emerged as particularly meaningful with regard to the latter, including direct strategies (a memory one and a cognitive one) and indirect strategies (two affective and two metacognitive). These strategies and their significance with reference to the local context as well as results previously reported in the literature are discussed. Finally, limitations of the study and implications for future research using cluster analysis are reported.

Published
2018

7. Novel allosteric glutaminase inhibitors with macrocyclic structure activity relationship analysis (part 2).

Author

Lee, Eun Ji, Jang, Jiyoon, Cyriac, Rajath, Yun, Mi Ran, Kwon, Yeongju, Jung, Myoung Eun, Choi, Gildon, Chae, Chong Hak, Cho, Byoung Chul, and Lee, Kwangho

Subjects
STRUCTURE-activity relationships, MOLECULAR docking, RAS oncogenes, CELL survival, MACROCYCLIC compounds, GLUTAMINE synthetase
Abstract

Glutamine‐addicted cancer metabolism is recently recognized as novel cancer target especially for KRAS and KEAP1 co‐occurring mutations. To identify more drug‐like GLS inhibitors, we report the amides in the wing macrocycles for GLS inhibition with unique SAR analysis. Although the amidotriazoles (amides in the wing) are in general less potent than those of acylaminothiadiazole analogs (reverse amides in the wing), macrocycle 4, 5, and 7 are selected as a potent macrocyclic GLS inhibitor in both biochemical and cell viability assays. Selected molecules result in partial reduction in intracellular glutamate levels in LR (LDK378‐resistant) cells which is consistent to their cells viability result. Finally, selected compounds reduce the growth of A549 and H460 cells which have co‐occurring mutations including KRAS and KEAP1. The putative binding mode of macrocycle 4 is also suggested using a molecular docking model. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Genomic Analysis and Tracking of SARS‐CoV‐2 Variants in Gwangju, South Korea, From 2020 to 2022.

Author

Lee, Yeong‐Un, Lee, Kwangho, Lee, Hongsu, Park, Jung Wook, Cho, Sun‐Ju, Park, Ji‐Su, Mun, Jeongeun, Park, Sujung, Lee, Cheong‐mi, Lee, Juhye, Seo, Jinjong, Kim, Yonghwan, Kim, Sun‐Hee, and Chung, Yoon‐Seok

Subjects
*COVID-19, *SARS-CoV-2, *SARS-CoV-2 Omicron variant, *GENOMICS, *COVID-19 pandemic, *COMMUNICABLE diseases
Abstract

Background: Since severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was first reported in Wuhan, China, in December 2019, it has spread rapidly, and many coronavirus disease (COVID‐19) cases have occurred in Gwangju, South Korea. Viral mutations following the COVID‐19 epidemic have increased interest in the characteristics of epidemics in this region, and pathogen genetic analysis is required for infection control and prevention. Methods: In this study, SARS‐CoV‐2 whole‐genome analysis was performed on samples from patients with COVID‐19 in Gwangju from 2020 to 2022 to identify the trends in COVID‐19 prevalence and to analyze the phylogenetic relationships of dominant variants. B.41 and B.1.497 prevailed in 2020, the early stage of the COVID‐19 outbreak; then, B.1.619.1 mainly occurred until June 2021. B.1.617.2, classified as sublineages AY.69 and AY.122, occurred continuously from July to December 2021. Since strict measures to strengthen national quarantine management had been implemented in South Korea until this time, the analysis of mutations was also able to infer the epidemiological relationship between infection transmission routes. Since the first identification of the Omicron variant in late December 2021, the spread of infection has been very rapid, and weekly whole‐genome analysis of specimens has enabled us to monitor new Omicron sublineages occurring in Gwangju. Conclusions: Our study suggests that conducting regional surveillance in addition to nation‐level genomic surveillance will enable more rapid and detailed variant surveillance, which will be helpful in the overall prevention and management of infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Re-Emergence of HMPV in Gwangju, South Korea, after the COVID-19 Pandemic

Author

Cho, Sun-Ju, primary, Kim, Sun-Hee, additional, Lee, Hongsu, additional, Lee, Yeong-Un, additional, Mun, Jeongeun, additional, Park, Sujung, additional, Park, Jungwook, additional, Park, Ji-Su, additional, Lee, Kwangho, additional, Lee, Cheong-mi, additional, Seo, Jinjong, additional, Kim, Yonghwan, additional, and Chung, Yoon-Seok, additional

Published
2023
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20. Re-emergence of HMPV in Gwangju, South Korea, After the COVID-19 Pandemic: Impact on Subtypes and Age Distribution

Author

Cho, Sun-Ju, primary, Kim, Sun-Hee, additional, Lee, Hongsu, additional, Lee, Yong-Un, additional, Mun, Jeongeun, additional, Park, Sujung, additional, Park, Jungwook, additional, Park, Ji-Su, additional, Lee, Kwangho, additional, Lee, Cheong-mi, additional, Seo, Jinjong, additional, Kim, Yonghwan, additional, and Chung, Yoon-Seok, additional

Published
2023
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24. Abstract 4029: JIN-A04, highly effective tyrosine kinase inhibitor targeting HER2 exon 20 insertion mutations in NSCLC

Author

Yu, Mi Ra, primary, Yun, Mi Ran, additional, Lee, Jii Bum, additional, Lee, Ji Yun, additional, Aum, So Won, additional, Choi, Su Jin, additional, Park, Ju Yeon, additional, Oh, Seung Yeon, additional, Lee, Eun Ji, additional, Duggirala, Krishna Babu, additional, Lee, Kwangho, additional, Hong, Min Hee, additional, Lim, Sun Min, additional, Jo, Anna, additional, Seah, Ethan, additional, Kim, Choonok, additional, and Cho, Byoung Chul, additional

Published
2023
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25. Supplementary Figure 8 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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26. Supplementary Figure 9 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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27. Supplementary Tables 1 through 4 and Supplementary Figures 1 through 5 from In Vitro and In Vivo Characterization of Irreversible Mutant-Selective EGFR Inhibitors That Are Wild-Type Sparing

Author

Tjin Tham Sjin, Robert, primary, Lee, Kwangho, primary, Walter, Annette O., primary, Dubrovskiy, Aleksandr, primary, Sheets, Michael, primary, Martin, Thia St., primary, Labenski, Matthew T., primary, Zhu, Zhendong, primary, Tester, Richland, primary, Karp, Russell, primary, Medikonda, Aravind, primary, Chaturvedi, Prasoon, primary, Ren, Yixuan, primary, Haringsma, Henry, primary, Etter, Jeff, primary, Raponi, Mitch, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Westlin, William F., primary, Petter, Russell C., primary, Allen, Andrew, primary, and Singh, Juswinder, primary

Published
2023
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28. Supplementary Figure 2 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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29. Data from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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30. Supplementary Materials and Methods from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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31. Supplementary Figure 7 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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32. Supplementary Figure 11 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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33. Supplementary Figure 3 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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34. Supplementary Table 2 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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35. Supplementary Table 1 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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36. Supplementary Table 3 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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37. Supplementary Materials and Methods and Supplementary Figure Legends from In Vitro and In Vivo Characterization of Irreversible Mutant-Selective EGFR Inhibitors That Are Wild-Type Sparing

Author

Tjin Tham Sjin, Robert, primary, Lee, Kwangho, primary, Walter, Annette O., primary, Dubrovskiy, Aleksandr, primary, Sheets, Michael, primary, Martin, Thia St., primary, Labenski, Matthew T., primary, Zhu, Zhendong, primary, Tester, Richland, primary, Karp, Russell, primary, Medikonda, Aravind, primary, Chaturvedi, Prasoon, primary, Ren, Yixuan, primary, Haringsma, Henry, primary, Etter, Jeff, primary, Raponi, Mitch, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Westlin, William F., primary, Petter, Russell C., primary, Allen, Andrew, primary, and Singh, Juswinder, primary

Published
2023
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38. Supplementary Figure 4 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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39. Supplementary Figure 5 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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40. Supplementary Figure 6 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Author

Walter, Annette O., primary, Sjin, Robert Tjin Tham, primary, Haringsma, Henry J., primary, Ohashi, Kadoaki, primary, Sun, Jing, primary, Lee, Kwangho, primary, Dubrovskiy, Aleksandr, primary, Labenski, Matthew, primary, Zhu, Zhendong, primary, Wang, Zhigang, primary, Sheets, Michael, primary, St Martin, Thia, primary, Karp, Russell, primary, van Kalken, Dan, primary, Chaturvedi, Prasoon, primary, Niu, Deqiang, primary, Nacht, Mariana, primary, Petter, Russell C., primary, Westlin, William, primary, Lin, Kevin, primary, Jaw-Tsai, Sarah, primary, Raponi, Mitch, primary, Van Dyke, Terry, primary, Etter, Jeff, primary, Weaver, Zoe, primary, Pao, William, primary, Singh, Juswinder, primary, Simmons, Andrew D., primary, Harding, Thomas C., primary, and Allen, Andrew, primary

Published
2023
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44. Discovery of TRD‐93 as a novel DRAK2 inhibitor

Author

Park, Sangjun, primary, Kye, Seungmin, additional, Jung, Myoung Eun, additional, Chae, Chong Hak, additional, Yang, Kyung‐Min, additional, Kim, Seong‐Jin, additional, Choi, Gildon, additional, and Lee, Kwangho, additional

Published
2023
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48. Venous outflow-targeted coil embolization of direct carotid-cavernous fistulas.

Author

Lee, Sang Hyub, Park, Hyun, Lee, Kwangho, Hwang, Soo Hyun, Lee, Chul Hee, Kang, Dong Ho, and Go, Kyeong-O

Subjects
CEREBRAL angiography, THERAPEUTIC embolization, CAVERNOUS sinus, FISTULA
Abstract

Background: Coil embolization is the mainstay treatment for carotid-cavernous fistulas (CCFs). However, few studies have reported entire occlusion of engorged veins to interrupt venous outflow. We report our experience with venous outflow-targeted coil embolization of direct CCFs. Methods: We retrospectively reviewed all the patients diagnosed with direct CCFs treated with venous outflow-targeted coil embolization between November 2013 and February 2020. Venous outflow-targeted coil embolization of the CCFs was performed as follows. First, transarterial stent-assisted coil embolization of CCFs was performed. If the venous outflow to the engorged veins persisted after transarterial stent-assisted coil embolization, entire occlusion of the engorged veins and additional coil packing within the cavernous sinus were performed to interrupt the venous outflow. Results: Ten patients had undergone venous outflow-targeted coil embolization, 6 women (60%) and 4 men (40%). Transfemoral cerebral angiography showed high-flow, direct CCFs in all the patients. Venous outflow occurred through the superior ophthalmic vein (SOV) in all the patients and was completely interrupted by the entire occlusion of the engorged veins with fibered coils. Three patients (30%) had undergone additional treatment in a supplementary manner because of recurrent symptoms (chemosis in 1 patient, faint tinnitus in 2 patients) in the early postprocedural period (1 to 4 weeks). All the symptoms were resolved on follow-up. No additional recurrence was found during follow-up (1–75 months). No peri-procedural complications were encountered. Conclusions: Venous outflow-targeted coil embolization of CCFs would be a safe and effective treatment method. [ABSTRACT FROM AUTHOR]

Published
2023
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