Search

Your search keyword '"Lei, Xiaoyong"' showing total 303 results
Start Over Author "Lei, Xiaoyong" Publication Year Range Last 10 years
303 results on '"Lei, Xiaoyong"'

12. From Human Oral Instructions to General Representations of Knowledge: A New Paradigm for Industrial Robots Skill Teaching

Author

Chen, Shiyu, Zhao, Yongjia, Lei, Xiaoyong, Qi, Tao, Liu, Kan, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Sun, Fuchun, editor, Hu, Dewen, editor, Wermter, Stefan, editor, Yang, Lei, editor, Liu, Huaping, editor, and Fang, Bin, editor

Published
2022
Full Text
View/download PDF

16. β‑Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β‑Cell Apoptosis

Author

Dedaki, Christina, Kokotou, Maroula G, Mouchlis, Varnavas D, Limnios, Dimitris, Lei, Xiaoyong, Mu, Carol T, Ramanadham, Sasanka, Magrioti, Victoria, Dennis, Edward A, and Kokotos, George

Subjects
Diabetes, Autoimmune Disease, Metabolic and endocrine, Animals, Apoptosis, Cytokines, Drug Design, Humans, Inflammation Mediators, Insulin-Secreting Cells, Lactones, Phospholipase A2 Inhibitors, Phospholipases A2, Calcium-Independent, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry
Abstract

Ca2+-independent phospholipase A2 (GVIA iPLA2) has gained increasing interest recently as it has been recognized as a participant in biological processes underlying diabetes development and autoimmune-based neurological disorders. The development of potent GVIA iPLA2 inhibitors is of great importance because only a few have been reported so far. We present a novel class of GVIA iPLA2 inhibitors based on the β-lactone ring. This functionality in combination with a four-carbon chain carrying a phenyl group at position-3 and a linear propyl group at position-4 of the lactone ring confers excellent potency. trans-3-(4-Phenylbutyl)-4-propyloxetan-2-one (GK563) was identified as being the most potent GVIA iPLA2 inhibitor ever reported ( XI(50) 0.0000021, IC50 1 nM) and also one that is 22 000 times more active against GVIA iPLA2 than GIVA cPLA2. It was found to reduce β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.

Published
2019

28. Microrna-96 In Human Cancers

Author

Yang, Xiaoyan, primary, Wu, Yiwen, additional, Xie, Zhizhong, additional, Deng, Sijun, additional, Xia, Yiniu, additional, and Lei, Xiaoyong, additional

Published
2023
Full Text
View/download PDF

30. The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia

Author

Zhang, Yuan, Wu, Xin, Sun, Xueyan, Yang, Jun, Liu, Chang, Tang, Guotao, Lei, Xiaoyong, Huang, Honglin, and Peng, Junmei

Abstract

Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. According to the American Cancer Society's 2021 cancer data report, new cases of CML account for about 15% of all leukemias. CML is generally divided into three stages: chronic phase, accelerated phase, and blast phase. Nearly 90% of patients are diagnosed as a chronic phase. Allogeneic stem cell transplantation and chemotherapeutic drugs, such as interferon IFN-α were used as the earliest treatments for CML. However, they could generate obvious side effects, and scientists had to seek new treatments for CML. A new era of targeted therapy for CML began with the introduction of imatinib, the first-generation BCR-ABL kinase inhibitor. However, the ensuing drug resistance and mutant strains led by T315I limited the further use of imatinib. With the continuous advancement of research, tyrosine kinase inhibitors (TKI) and BCR-ABL protein degraders with novel structures and therapeutic mechanisms have been discovered. From biological macromolecules to classical target protein inhibitors, a growing number of compounds are being developed to treat chronic myelogenous leukemia. In this review, we focus on summarizing the current situation of a series of candidate small-molecule drugs in CML therapy, including TKIs and BCR-ABL protein degrader. The examples provided herein describe the pharmacology activity of small-molecule drugs. These drugs will provide new enlightenment for future treatment directions.

Published
2024
Full Text
View/download PDF

31. Variance state propagation for uplink channel estimation in LEO satellite systems.

Author

Lei, Xiaoyong, Zhang, Mingchen, Liu, Yilun, and Zhang, Yong

Subjects
*CHANNEL estimation, *ORTHOGONAL frequency division multiplexing, *DOPPLER effect, *ITERATIVE learning control
Abstract

This paper, considers the channel estimation problem of the uplink low Earth orbit (LEO) satellite orthogonal frequency division multiplexing (OFDM) system. By exploiting the channel structured sparsity in the delay‐Doppler‐angle domain, the channel estimation problem is formulated as a block‐sparse signal recovery problem. The variance state propagation (VSP) framework is extended to solve such a problem. Considering that the delay, Doppler shift, and angle of departure (AoD) of each propagation path may not exactly fall on the presumed discrete grid points, an expectation maximization (EM) based parameter learning scheme in VSP to iteratively update the grid parameters is introduced. Simulation results demonstrate that the proposed approach achieves a substantial performance gain over the existing methods. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. A Novel Fusion Method of Infrared and Visible Images Based on Non-subsampled Contourlet Transform

Author

Lu, Fei, Lei, Xiaoyong, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Zhang, Yu-Jin, editor

Published
2015
Full Text
View/download PDF

33. A Modified Fourier Descriptor for Shape-Based Image Recognition

Author

Huo, Lichao, Lei, Xiaoyong, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Zhang, Yu-Jin, editor

Published
2015
Full Text
View/download PDF

48. Roles of ABCA1 in cancer

Author

Wu, Kun, Zou, Longwei, Lei, Xiaoyong, and Yang, Xiaoyan

Subjects
Review
Abstract

Studies have indicated that anticancer drugs targeting cholesterol metabolism have clinical significance. From the perspective of the mechanism of cholesterol excretion from cells, ATP-binding cassette (ABC)A1 has an essential role that cannot be ignored. ABCA1 is located on the cell membrane and able to mediate the efflux of lipids, such as intracellular cholesterol, thereby initiating reverse cholesterol transport to reduce the intracellular cholesterol level. Therefore, inducing the expression of ABCA1 may become a new breakthrough point in cancer therapy.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results