99 results on '"Li, Hua-Yu"'
Search Results
2. High myopia control is comparable between multifocal rigid gas-permeable lenses and spectacles
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Li-hua Yu, Ran Zhuo, Guan-xing Song, Meng Lin, and Wan-qing Jin
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axial length ,high myopia ,multifocal rigid gas-permeable lens ,myopia control ,lens design ,Medicine (General) ,R5-920 - Abstract
PurposeOcular pathology may be reduced by slowing myopia progression. The purpose of this study was to evaluate the potential of a novel custom-designed rigid gas permeable (RGP) contact lens to control high myopia by comparing the efficacy of multifocal RGP lenses and single-vision spectacles for high myopia control.MethodsThe medical records of children fitted with spectacles or multifocal rigid gas-permeable lenses between January 2018 and May 2020 were retrospectively reviewed. Children (5–17 years) with non-cycloplegic spherical equivalent refraction of ≤ −6.00 D or spherical equivalent refraction > − 6.00 D with baseline axial length ≥ 26.5 mm, and astigmatism of ≥ −2.00 D were included. Axial length and refraction were measured at baseline, before fitting the participants with multifocal rigid gas-permeable lenses or spectacles, and at 1- and 2-year follow-up visits. Changes in axial length were compared between the groups.ResultsAmong the 77 children with 1-year follow-up data, the mean axial elongation was 0.20 ± 0.17 mm and 0.21 ± 0.14 mm in the multifocal rigid gas-permeable and control groups, respectively, without significant differences between groups (F = 0.004, p = 0.835). Among the 41 patients who completed 2 years of follow-up, the mean axial elongation values in the multifocal rigid gas-permeable and control groups were 0.21 ± 0.15 mm and 0.24 ± 0.13 mm, respectively, at the 1-year follow-up, and 0.37 ± 0.27 mm and 0.43 ± 0.23 mm, respectively, at the 2-year follow-up, without significant between-group differences at either time point (p = 0.224).ConclusionAxial length increased at a similar rate in both the control (spectacles) and multifocal rigid gas-permeable lens groups, suggesting that multifocal rigid gas-permeable lenses have no significant impact on controlling high myopia progression compared with spectacles.
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- 2023
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3. OliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets
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Yang, Zhi-Xue, primary, Deng, Dong-Hao, additional, Gao, Zhu-Ying, additional, Zhang, Zhi-Kang, additional, Fu, Ya-Wen, additional, Wen, Wei, additional, Zhang, Feng, additional, Li, Xiang, additional, Li, Hua-Yu, additional, Zhang, Jian-Ping, additional, and Zhang, Xiao-Bing, additional
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- 2024
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4. Differential Privacy Based Fingerprinting Obfuscation Mechanism Towards NetworkReconnaissance Deception
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HE Yuan, XING Chang-you, ZHANG Guo-min, SONG Li-hua, YU Hang
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fingerprinting obfuscation ,differential privacy ,network reconnaissance ,cyber deception defense ,Computer software ,QA76.75-76.765 ,Technology (General) ,T1-995 - Abstract
Network fingerprinting detection is an important network reconnaissance method,which can be used by attackers to obtain the fingerprinting characteristics of the target network,and then provide support for subsequent targeted attacks.Fingerprinting obfuscation technology enables attackers to form fake fingerprinting views by actively modifying the fingerprinting features in response packets.However,existing obfuscation methods are still insufficient in dealing with attackers’ strategic detection and analysis.To this end,a differential privacy based fingerprinting obfuscation mechanism(DPOF) towards network reconnaissance deception is proposed.Taking the idea of data privacy protection as a reference,DPOF first establishes a utility-driven differential privacy fingerprinting obfuscation model,and calculates the obfuscation probability of fake fingerprints with different utilities through the differential privacy exponential mechanism.On this basis,a fingerprinting obfuscation decision method under resource constraint is further designed,and an obfuscation strategy solving algorithm based on particle swarm optimization is implemented.Simulation results show that compared with the existing typical fingerprinting obfuscation methods,DPOF has better fingerprinting obfuscation effect with different problem scales and budgets,and can obtain a better approximate optimal strategy at a faster speed.
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- 2022
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5. Mesencephalic astrocyte-derived neurotrophic factor (MANF) prevents the neuroinflammation induced dopaminergic neurodegeneration
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Jing-Xing Zhang, Kai-Ge Zhou, Yan-Xin Yin, Ling-Jing Jin, Wei-Fang Tong, Jia Guo, Li-Hua Yu, Xian-Cheng Ye, and Ming Jiang
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Parkinson's disease (PD) ,Mesencephalic astrocyte-derived neurotrophic factor (MANF) ,Dopaminergic neurodegeneration ,Neuroinflammation ,Nrf-2 ,Microglia activation ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background: The excessive activation of the microglia leads to the release of inflammatory factors that contribute to neuronal cell loss and neurodegeneration in Parkinson's Disease (PD). Mesencephalic astrocyte-derived neurotrophic factor (MANF) that belongs to a newly found neurotrophic factors (NTFs) family has been reported to promote neuronal survival in the PD models. However, the effects of the MANF on neuroinflammation in PD remain unclear. Methods: AAV8-MANF virus was constructed to determine whether the high expression of MANF can protect the neuroinflammation-induced dopaminergic neurodegeneration in rats with 6-OHDA-induced PD. Rotarod performance test, immunofluorescent staining and western bolt were employed to evaluate the behavioral dysfunction, dopaminergic neurodegeneration, microglia activation, and signal activation. 6-OHDA treated SH-SY5Y cells and LPS treated BV-2 cells were used as the in vitro model for MANF neuroprotective and neuroinflammation mechanisms. Cell vitality and apoptosis were evaluated with MTT, CCK-8 and flow cytometric analysis. The AKT/GSK3β-Nrf2 signaling and the TNF-α/IL6 expression were measured by Western Blot. Results: Our findings indicated that the elevated MANF expression by the AAV8-MANF administration ameliorated the motor dysfunction and protected the dopaminergic neurons in the 6-OHDA treated rats. The upregulated CD11b in the rat SN caused by the 6-OHDA administration was significantly attenuated by the pretreatment of the AAV8-MANF. Furthermore, the levels of p-AKT, p-GSK3β, BCL-2, and Nrf-2 were upregulated by the high expression of the MANF. Under the oxidative stress of the 6-OHDA, the MANF significantly reduced the apoptotic effect of the TNF-α on the SH-SY5Y cells. In the LPS treated BV-2 cells, the MANF reduced the production of the TNF-α and IL-6, via enhancing the Nrf-2, p-Akt, p-GSK3β, and p-NF-κβ level. Conclusions: These results suggested that the MANF prevented the dopaminergic neurodegeneration caused by the microglia activation in PD via activation of the AKT/GSK3β-Nrf-2 signaling axis.
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- 2023
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6. Common key ingredient concluded in Baitouweng decoction, GegenQinliandecoction and Shaoyao decoction prevents radiation enteritis by regulatinggutmicrobial network.
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Tian-hao Liu, Ying-yue Sheng, Chen-yang Zhang, Hang Zhang, Xue Li, Li-hua Yu, Ling-ling Xu, Lin Zhao, Hong Wei, Ya-hong Zhou, and Yu-zheng Xue
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ENTERITIS ,GUT microbiome ,HERBAL medicine ,QUERCETIN ,LIQUID chromatography - Abstract
Background: The gut microbiota is crucial in the process of radiation enteritis (RE). Asrecommended by Chinese expert consensus, three formulas such as Baitouweng decoction, Gegen Qinlian decoction, and Shaoyao decoction, are used to prevent the same type of RE. Methods: Herein, we aimed to investigate the common pharmaceutical ingredients andmolecular mechanisms of the three formulas on RE from the perspective of gut microbiotathrough multi-bioinformatics analysis and mouse experiment. Results: Interestingly, theimportant active ingredient screened was quercetin in all three herbal formulas, andthedominant targets that participated in RE treatment by targeting gut microbiota regulationwere IL10, STAT1, IL1B, and IL1A. The concentration of quercetin was measured inGegenQinlian decoction > Shaoyao decoction > Baitouweng decoction (P <0.001) usinghighperformance liquid chromatography. Moreover, a total of 40 SPF C57/BL6J (male, 12–14weeks old) mice were assigned to perform the validation experiment with various quercetinintervention doses. Quercetin significantly protected against inflammatory responseinradiation induced-mice. The microbial alterations in the gut caused by quercetinintervention in radiation-induced mice were also explained. We further confirmedthealterations in the relative mRNA expression of the three formulas for the treatment of RE, which have four similar gut microbiota-regulated targets (IL10, STAT1, IL1B, andIL1A). Conclusion: These findings show that quercetin regulated the gut microbiota for REtherapy, a connotation that works on the principle of “different treatments for the samedisease” for RE. The present investigation provides methodological guidelines and protocolsfor the modern use and examination of traditional therapeutic concepts. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Convergence map with action-angle variables based on square matrix for nonlinear lattice optimization
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Li Hua Yu, Yoshiteru Hidaka, Victor Smaluk, Kelly Anderson, and Yue Hao
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
To analyze nonlinear dynamic systems, we developed a new technique based on the square matrix method. We propose this technique called the “convergence map” for generating particle stability diagrams similar to the frequency maps widely used in accelerator physics to estimate dynamic aperture. The convergence map provides similar information as the frequency map but in a much shorter computing time. The dynamic equation can be rewritten in terms of action-angle variables provided by the square matrix derived from the accelerator lattice. The convergence map is obtained by solving the exact nonlinear equation iteratively by the perturbation method using Fourier transform and studying convergence numerically. When the iteration is convergent, the solution is expressed as a quasiperiodic analytical function as a highly accurate approximation and hence the motion is stable. The border of stable motion determines the dynamical aperture. As an example, we applied the new method to the nonlinear optimization of the NSLS-II storage ring and demonstrated a dynamic aperture comparable to or larger than the nominal one obtained by particle tracking. The computation speed of the convergence map is 30 to 300 times faster than the speed of the particle tracking, depending on the size of the ring lattice (number of superperiods). The computation speed ratio is larger for complex lattices with low symmetry, such as particle colliders.
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- 2023
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8. Convergence map with action-angle variables based on square matrix for nonlinear lattice optimization.
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Li Hua Yu, Yoshiteru Hidaka, and Victor Smaluk
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- 2022
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9. The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis
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Zhan-ying Lu, Juan Fan, Li-hua Yu, Bei Ma, and Li-ming Cheng
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trigeminal neuralgia ,TNF-α ,trigeminal nucleus caudalis ,MAPKs phosphorylation ,BKCa channel ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Trigeminal neuralgia (TN) is a severe chronic neuropathic pain. Despite numerous available medical interventions, the therapeutic effects are not ideal. To control the pain attacks, the need for more contemporary drugs continues to be a real challenge. Our previous study reported that Ca2+-activated K+ channels (BKCa) channels modulated by mitogen-activated protein kinases (MAPKs) in the trigeminal ganglia (TG) neurons play crucial roles in regulating TN, and some research studies demonstrated that inflammatory cytokine tumor necrosis factor alpha (TNF-α) could promote neuropathic pain. Meanwhile, the trigeminal nucleus caudalis (TNC), the first central site of the trigeminal nociceptive pathway, is responsible for processing sensory and pain signals from the peripheral orofacial area. Thus, this study is aimed to further investigate whether TNF-α and MAPKs phosphorylation in the TNC could mediate the pathogenesis of TN by modulating BKCa channels. The results showed that TNF-α of the TNC region is upregulated significantly in the chronic constriction injury of infraorbital nerve (ION-CCI) rats model, which displayed persistent facial mechanical allodynia. The normal rats with target injection of exogenous TNF-α to the fourth brain ventricle behaved just like the ION-CCI model rats, the orofacial mechanical pain threshold decreased clearly. Meanwhile, the exogenous TNF-α increased the action potential frequency and reduced the BKCa currents of TNC neurons significantly, which could be reversed by U0126 and SB203580, the inhibitors of MAPK. In addition, U0126, SB203580, and another MAPK inhibitor SP600125 could relieve the facial mechanical allodynia by being injected into the fourth brain ventricle of ION-CCI model rats, respectively. Taken together, our work suggests that the upregulation of TNF-α in the TNC region would cause the increase of MAPKs phosphorylation and then the negative regulation of BKCa channels, resulting in the TN.
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- 2021
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10. A comment on “A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B.” (J Hepatol. 2023 May;78(5):926-936.)
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Wan, Yue-Meng, primary, Wu, Hua-Mei, additional, Huang, Song-Quan, additional, Li, Hua-Yu, additional, and Yin, Hong-Jing, additional
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- 2023
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11. Ceramic particle-induced accelerated solution-aging behavior of spray-formed 7055 aluminum alloy TIG weld metal
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Yun Cheng, Wei-xia Yuan, Jun-hua Xu, Li-hua Yu, Yun-xuan Hu, Ting Huang, and Hao Zhang
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2023
12. Retraction: The Inhibitory Effect of Doxycycline on Cisplatin-Sensitive and -Resistant Epithelial Ovarian Cancer.
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Wei Wu, Li-Hua Yu, Bei Ma, Ming-Juan Xu, and PLOS ONE Editors
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Medicine ,Science - Published
- 2020
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13. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver
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Tao Zeng, Cui-Li Zhang, Ning Zhao, Min-Jie Guan, Mo Xiao, Rui Yang, Xiu-Lan Zhao, Li-Hua Yu, Zhen-Ping Zhu, and Ke-Qin Xie
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Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment of Akt activity has been demonstrated to be involved in the development of non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that cytochrome P4502E1 (CYP2E1) plays causal roles in the pathogenesis of alcoholic fatty liver (AFL). We hypothesized that Akt activity might be impaired due to CYP2E1-induced oxidative stress in chronic ethanol-induced hepatic steatosis. In this study, we found that chronic ethanol-induced hepatic steatosis was accompanied with reduced phosphorylation of Akt at Thr308 in mice liver. Chronic ethanol exposure had no effects on the protein levels of phosphatidylinositol 3 kinase (PI3K) and phosphatase and tensin homologue deleted on chromosome ten (PTEN), and led to a slight decrease of phosphoinositide-dependent protein kinase 1 (PDK-1) protein level. Ethanol exposure resulted in increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)-Akt adducts, which was significantly inhibited by chlormethiazole (CMZ), an efficient CYP2E1 inhibitor. Interestingly, N-acetyl-L-cysteine (NAC) significantly attenuated chronic ethanol-induced hepatic fat accumulation and the decline of Akt phosphorylation at Thr308. In the in vitro studies, Akt phosphorylation was suppressed in CYP2E1-expressing HepG2 (CYP2E1-HepG2) cells compared with the negative control HepG2 (NC-HepG2) cells, and 4-HNE treatment led to significant decrease of Akt phosphorylation at Thr308 in wild type HepG2 cells. Lastly, pharmacological activation of Akt by insulin-like growth factor-1 (IGF-1) significantly alleviated chronic ethanol-induced fatty liver in mice. Collectively, these results indicate that CYP2E1-induced oxidative stress may be responsible for ethanol-induced suppression of Akt phosphorylation and pharmacological modulation of Akt in liver may be an effective strategy for the treatment of ethanol-induced fatty liver. Keywords: Alcoholic fatty liver, Protein kinase B, Cytochrome P4502E1, Oxidative stress, Insulin-like growth factor-1
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- 2018
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14. Synthesis and Evaluation of Novel Nitric Oxide-Donating Ligustrazine Derivatives as Potent Antiplatelet Aggregation Agents
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Li, Han-Xu, primary, Tian, Jian-Hui, additional, Li, Hua-Yu, additional, Wan, Xin, additional, and Zou, Yu, additional
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- 2023
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15. Study on Preparation and Properties of PPB/POE/Calcite Waste Powder Composites.
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MA Lan-yu, LAI Wen-qin, XIE Song-bo, LI Hua-yu, CHEN Zhao-lun, and HUANG Yi-feng
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CALCITE ,IMPACT strength ,THERMAL properties ,POWDERS ,TEMPERATURE effect ,ELASTOMERS ,THERMOPLASTIC elastomers - Abstract
In order to realize the resource utilization of calcite tailings corner waste, block copolymerized polypropylene (PPB)/polyolefin elastomer (POE)/calcite waste powder ternary composites were prepared by melt blending modified extrusion method. The effects of waste powder content and POE content on mechanical properties, thermal properties and microstructure of composites were investigated. The results show that POE can improve compatibility of composites, and calcite waste powder can significantly enhance stiffness. Adding 10 phr of calcite waste powder and 20 phr of POE to the PPB base material can improve compatibility between inorganic filler and resin substrate and significantly improve mechanical properties of composites. The impact strength of composites is increased to 55.48 kJ/m2 by the coordination of calcite waste powder and POE. POE and calcite waste powder both reduce the crystallinity of composites, have little effect on melting temperature, and slightly increase crystallization temperature. PPB, POE and calcite waste powder are compounded to prepare composites, which provided a new way to solve the application problem of calcite tailings. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Experimental Research on Water Boiling Heat Transfer on Horizontal Copper Rod Surface at Sub-Atmospheric Pressure
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Li-Hua Yu, Shu-Xue Xu, Guo-Yuan Ma, and Jun Wang
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water ,sub-atmospheric pressure ,boiling heat transfer ,regression equation ,Technology - Abstract
In recent years, water (R718) as a kind of natural refrigerant—which is environmentally-friendly, safe and cheap—has been reconsidered by scholars. The systems of using water as the refrigerant, such as water vapor compression refrigeration and heat pump systems run at sub-atmospheric pressure. So, the research on water boiling heat transfer at sub-atmospheric pressure has been an important issue. There are many research papers on the evaporation of water, but there is a lack of data on the characteristics at sub-atmospheric pressures, especially lower than 3 kPa (the saturation temperature is 24 °C). In this paper, the experimental research on water boiling heat transfer on a horizontal copper rod surface at 1.8–3.3 kPa is presented. Regression equations of the boiling heat transfer coefficient are obtained based on the experimental data, which are convenient for practical application.
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- 2015
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17. A comment on “A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B”
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Wan, Yue-Meng, Wu, Hua-Mei, Huang, Song-Quan, Li, Hua-Yu, and Yin, Hong-Jing
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- 2024
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18. [Post-stroke shoulder-hand syndrome of phlegm-stasis obstruction treated with the combined therapy of eye acupuncture
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Mei, Wang, Peng-Qin, Wang, Li-Hua, Yu, Chen-Yang, Wang, and Yan, Shao
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Reflex Sympathetic Dystrophy ,Stroke ,Treatment Outcome ,Acupuncture Therapy ,Stroke Rehabilitation ,Humans ,Pain ,Acupuncture Points - Abstract
To assess the efficacy on relieving pain and improving the range of motion of shoulder joint in post-stroke shoulder-hand syndrome of phlegm-stasis obstruction in treatment of the combined therapy of eye acupuncture,A total of 356 patients with post-stroke shoulder-hand syndrome of phlegm-stasis obstruction were randomized into an eye acupuncture +The scores of VAS, GEPI and NIHSS were all improved with the treatment lasting in the three groups (The combined therapy of eye acupuncture
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- 2022
19. Defect-engineered surfaces to investigate the formation of self-assembled molecular networks
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Li-Hua Yu, Zhen-Feng Cai, Lander Verstraete, Yuanzhi Xia, Yuan Fang, Louis Cuccia, Oleksandr Ivasenko, and Steven De Feyter
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GRAPHENE ,Science & Technology ,GRAPHITE ,DIAZONIUM CHEMISTRY ,IMPACT ,Chemistry, Multidisciplinary ,COOPERATIVITY ,ORGANIZATION ,General Chemistry ,INTERFACE ,Chemistry ,POLYMERIZATION ,Physical Sciences ,COVALENT FUNCTIONALIZATION ,CORRALS - Abstract
Herein we report the impact of covalent modification (grafting), inducing lateral nanoconfinement conditions, on the self-assembly of a quinonoid zwitterion derivative into self-assembled molecular networks at the liquid/solid interface. At low concentrations where the compound does not show self-assembly behaviour on bare highly oriented pyrolytic graphite (HOPG), close-packed self-assembled structures are visualized by scanning tunneling microscopy on covalently modified HOPG. The size of the self-assembled domains decreases with increasing the density of grafted molecules, i.e. the molecules covalently bound to the surface. The dynamics of domains are captured with molecular resolution, revealing not only time-dependent growth and shrinkage processes but also the orientation conversion of assembled domains. Grafted pins play a key role in initiating the formation of on-surface molecular self-assembly and their stabilization, providing an elegant route to study various aspects of nucleation and growth processes of self-assembled molecular networks., Chemical Science, 13 (44), ISSN:2041-6520, ISSN:2041-6539
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- 2022
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20. Antibody responses to SARS-CoV-2 in patients with COVID-19
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Hua Wen Liu, Jun Yuan, Jin Jing Li, Hai Jun Deng, Shao Bo Wu, Xiao Ping Cui, Man Man Zhu, Fang Gong, Juan Chen, Jie Li Hu, Xiao He Luo, Zhi Jie Li, Xiao Feng Li, Wen Guang Tian, Li Hu, Liu Ping, Chun Hui Lang, Jing Wang, Kun Deng, Yuan Hu, Kun Wang, Li Hua Yu, Jing Fu Qiu, Deqiang Wang, Cheng Jun Xue, Yong Zhang, Bai Zhong Liu, Xiao-li Zhang, Yin Yin Xu, Yong Lin, Qing Jun Yang, Fan Zhang, Xian Xiang Zhang, Zhan Mo, Xue Fei Cai, Yao Kai Chen, Qin Li, Ailong Huang, Ji Hua Ren, Xia Mao Liu, De Chun Zhang, Ni Tang, Quanxin Long, Gui Cheng Wu, Jiang Lin Xiang, Li Wang, Pu Liao, Xiaojun Tang, Hong Xin Du, Zheng Zhou, and Chang Chun Niu
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Adult ,Male ,0301 basic medicine ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Antibodies, Viral ,Antiviral Agents ,Asymptomatic ,General Biochemistry, Genetics and Molecular Biology ,Serology ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Seroconversion ,Pandemics ,Aged ,biology ,SARS-CoV-2 ,business.industry ,COVID-19 ,General Medicine ,Middle Aged ,medicine.disease ,Pneumonia ,Titer ,030104 developmental biology ,Immunoglobulin M ,Immunoglobulin G ,030220 oncology & carcinogenesis ,Antibody Formation ,Immunology ,biology.protein ,Female ,Antibody ,medicine.symptom ,Coronavirus Infections ,business - Abstract
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
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- 2020
21. Class 2 Heating Cycles: A New Class of Thermodynamic Cycles
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Li, Hua-Yu, primary and Li, Hong-Rui, additional
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- 2021
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22. Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder
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Xin-xiang Zhang, Yan-yun Liu, Li-hua Yu, Jia-ming Yu, Dao-jun Xie, and Juan Zhang
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Sleep Wake Disorders ,Parkinson's disease ,Article Subject ,Computational biology ,Biology ,Network Pharmacology ,General Biochemistry, Genetics and Molecular Biology ,Antioxidants ,GeneCards ,medicine ,Humans ,KEGG ,Kaempferols ,Medicine, Chinese Traditional ,General Immunology and Microbiology ,Parkinson Disease ,General Medicine ,AutoDock ,medicine.disease ,Molecular Docking Simulation ,Mechanism of action ,Medicine ,Quercetin ,UniProt ,Signal transduction ,medicine.symptom ,Systems pharmacology ,Drugs, Chinese Herbal ,Signal Transduction ,Research Article - Abstract
This study is aimed at exploring the possible mechanism of action of the Suanzaoren decoction (SZRD) in the treatment of Parkinson’s disease with sleep disorder (PDSD) based on network pharmacology and molecular docking. Traditional Chinese Medicine Systems Pharmacology (TCMSP) was used to screen the bioactive components and targets of SZRD, and their targets were standardized using the UniProt platform. The disease targets of “Parkinson’s disease (PD)” and “Sleep disorder (SD)” were collected by OMIM, GeneCards, and DisGeNET databases. Thereafter, the protein-protein interaction (PPI) network was constructed using the STRING platform and visualized by Cytoscape (3.7.2) software. Then, the DAVID platform was used to analyze the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Cytoscape (3.7.2) software was also used to construct the network of the “herb-component-target-pathway.” The core active ingredients and core action targets of the drug were verified by molecular docking using AutoDock software. A total of 135 Chinese herbal components and 41 corresponding targets were predicted for the treatment of PDSD using SZRD. Fifteen important signaling pathways were screened, such as the cancer pathway, TNF signaling pathway, PI3K-AKT signaling pathway, HIF-1 signaling pathway, and Toll-like receptor signaling pathway. The results of molecular docking showed that the main active compounds could bind to the representative targets and exhibit good affinity. This study revealed that SZRD has the characteristics and advantages of “multicomponent, multitarget, and multipathway” in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms. This study provides a theoretical basis for further study of the material basis and molecular mechanism of SZRD in the treatment of PDSD.
- Published
- 2021
23. Genetic algorithm enhanced by machine learning in dynamic aperture optimization
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Yongjun Li, Weixing Cheng, Li Hua Yu, and Robert Rainer
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
With the aid of machine learning techniques, the genetic algorithm has been enhanced and applied to the multi-objective optimization problem presented by the dynamic aperture of the National Synchrotron Light Source II (NSLS-II) Storage Ring. During the evolution processes employed by the genetic algorithm, the population is classified into different clusters in the search space. The clusters with top average fitness are given “elite” status. Intervention on the population is implemented by repopulating some potentially competitive candidates based on the experience learned from the accumulated data. These candidates replace randomly selected candidates among the original data pool. The average fitness of the population is therefore improved while diversity is not lost. Maintaining diversity ensures that the optimization is global rather than local. The quality of the population increases and produces more competitive descendants accelerating the evolution process significantly. When identifying the distribution of optimal candidates, they appear to be located in isolated islands within the search space. Some of these optimal candidates have been experimentally confirmed at the NSLS-II storage ring. The machine learning techniques that exploit the genetic algorithm can also be used in other population-based optimization problems such as particle swarm algorithm.
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- 2018
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24. Class 1 Heating Cycles: A New Class of Thermodynamic Cycles
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Li, Hong-Rui, primary and Li, Hua-Yu, additional
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- 2021
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25. Acupuncture plus Chinese Herbal Medicine for Irritable Bowel Syndrome with Diarrhea: A Systematic Review and Meta-Analysis
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Zhiwei Miao, Lina Liu, Fei Ge, Li-hua Yu, Jun Lu, Wenbin Shang, Zhiguang Sun, and Jing Yan
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medicine.medical_specialty ,business.industry ,MEDLINE ,lcsh:Other systems of medicine ,Review Article ,lcsh:RZ201-999 ,Confidence interval ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Complementary and alternative medicine ,Randomized controlled trial ,law ,Strictly standardized mean difference ,Meta-analysis ,Internal medicine ,Relative risk ,Acupuncture ,Medicine ,030211 gastroenterology & hepatology ,030212 general & internal medicine ,business ,Adverse effect - Abstract
Purpose. To comprehensively evaluate the efficacy and safety of acupuncture combined with Chinese herbal medicine (CHM) in treating irritable bowel syndrome with diarrhea (IBS-D). Methods. Relevant randomized controlled trials (RCTs) were systemically retrieved from electronic databases from inception to March 2018, including the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biological Medical Database (CBM, SinoMed), China Science and Technology Journal Database (VIP), and Wan Fang Data. Meanwhile, pooled estimates, including the 95% confidence interval (CI), were calculated for primary and secondary outcomes of IBS-D patients. Besides, quality of relevant articles was evaluated using the Cochrane Collaboration’s risk of bias tool, and the Review Manager 5.3 and Stata12.0 softwares were employed for analyses. Results. A total of 21 RCTs related to IBS-D were included into this meta-analysis. Specifically, the pooled results indicated that (1) acupuncture combined with CHM might result in more favorable improvements compared with the control group (relative risk [RR] 1.29; 95% CI 1.24–1.35; P =0.03); (2) the combined method could markedly enhance the clinical efficacy in the meantime of remarkably reducing the scores of abdominal pain (standardized mean difference [SMD] –0.45; 95% CI –0.72, –0.17; P = 0.002), abdominal distention/discomfort (SMD –0.36; 95% CI –0.71, –0.01; P = 0.04), diarrhea (SMD –0.97; 95% CI –1.18, –0.75; P < 0.00001), diet condition (SMD –0.73; 95% CI –0.93, –0.52; P Conclusions. Findings in this study indicate that acupuncture combined with CHM is suggestive of an effective and safe treatment approach for IBS-D patients, which may serve as a promising method to treat IBS-D in practical application. However, more large-scale, multicenter, long-term, and high-quality RCTs are required in the future, given the small size, low quality, and high risk of the studies identified in this meta-analysis.
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- 2019
26. Analysis of nonlinear dynamics by square matrix method
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Li Hua Yu
- Subjects
Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The nonlinear dynamics of a system with periodic structure can be analyzed using a square matrix. We show that because of the special property of the square matrix constructed for nonlinear dynamics, we can reduce the dimension of the matrix from the original large number for high order calculations to a low dimension in the first step of the analysis. Then a stable Jordan decomposition is obtained with much lower dimension. The Jordan decomposition leads to a transformation to a new variable, which is an accurate action-angle variable, in good agreement with trajectories and tune obtained from tracking. More importantly, the deviation from constancy of the new action-angle variable provides a measure of the stability of the phase space trajectories and tune fluctuation. Thus the square matrix theory shows a good potential in theoretical understanding of a complicated dynamical system to guide the optimization of dynamical apertures. The method is illustrated by many examples of comparison between theory and numerical simulation. In particular, we show that the square matrix method can be used for fast optimization to reduce the nonlinearity of a system.
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- 2017
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27. Influence of Ag Content on the Microstructure, Mechanical, and Tribological Properties of ZrN-Ag Films
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Tong Chen, Yao Xiang Geng, Ho Bong Ju, Shinji Koyama, Li Hua Yu, and Jun Hua Xu
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010302 applied physics ,Materials science ,0103 physical sciences ,02 engineering and technology ,Tribology ,Composite material ,021001 nanoscience & nanotechnology ,0210 nano-technology ,Microstructure ,01 natural sciences - Abstract
A series of ZrN-Ag nano-composite films were deposited using the RF magnetron sputtering system. The microstructure, mechanical properties and tribological performances were investigated. The results showed that ZrN-Ag films were composed of face-centered cubic (fcc)-ZrN and face-centered cubic (fcc)-Ag. With the increase of Ag content, the hardness of ZrN-Ag composite film increased rapidly and then decreased rapidly. The maximum hardness value was 22.8 GPa at 6.1at.% Ag. At room temperature, the coefficient of friction (Cof.) of ZrN-Ag films were lower than the ZrN film. During 25-500°C, the Cof. of ZrN-Ag films at 29.16 at.% Ag were lower than ZrN film, while the wear rate were higher than the ZrN film. In summary, the addition of Ag improved the hardness, and decreased the Cof. of the ZrN-Ag during 25-500°C.
- Published
- 2018
28. Leptin correlates with monocytes activation and severe condition in COVID‐19 patients
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Ying Xie, Hongmei Jiang, Zhiqiang Liu, Ziyi Peng, Bei-zhong Liu, Sheng Wang, Jinsong Hu, Jingya Wang, Jingjing Wang, Xiao-li Zhang, Yin-yin Xu, Jing Guo, Jing Liu, Xin Li, Chao Wan, Juan Liao, and Li-hua Yu
- Subjects
0301 basic medicine ,biology ,Leptin ,Lymphocyte ,medicine.medical_treatment ,Monocyte ,Immunology ,Cell Biology ,Proinflammatory cytokine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Immune system ,medicine.anatomical_structure ,Cytokine ,030220 oncology & carcinogenesis ,biology.protein ,medicine ,Immunology and Allergy ,Signal transduction ,STAT3 - Abstract
Excessive monocyte activation with the development of excessive or uncontrolled release of proinflammatory cytokines often results in host tissue injury and even death in patients with pneumonia caused by the 2019 novel coronavirus. However, the changes of cytokine profiles of coronavirus disease 2019 (COVID-19) patients, as well as the underlying mechanisms that are involved, remain unknown. Using a cytokine array containing 174 inflammation-related cytokines, we found significantly altered cytokine profiles in severe COVID-19 patients compared with those in mild patients or healthy controls, and identified leptin, CXCL-10, IL-6, IL-10, IL-12, and TNF-α as the top differentially expressed cytokines. Notably, leptin showed high consistency with CXCL-10 and TNF-α in predicting disease severity, and correlated with body mass index, decreased lymphocyte counts, and disease progression. Further analysis demonstrated that monocytes in severe patients with higher leptin levels were inclined toward M1 polarization. Mechanistic studies revealed that leptin synergistically up-regulated expression levels of inflammatory cytokines and surface markers with IL-6 in monocytes through STAT3 and NF-κB signaling pathways. Collectively, our results suggest that overweight COVID-19 patients were prone to have higher leptin levels, which further activated monocytes, resulting in amplified or dysregulated immune responses. Taken together, our findings argue that leptin correlates severity of COVID-19 and may indicate a possible mechanism by which overweight patients have a greater tendency to develop severe conditions.
- Published
- 2021
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29. Medium Energy Hard X-ray FEL Gain
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Li Hua Yu
- Subjects
Materials science ,Optics ,Medium energy ,business.industry ,X-ray ,business - Published
- 2020
30. Enhancing the stability and electrocatalytic activity of Ti-based PbO2 anodes by introduction of an arc-sprayed TiN interlayer
- Author
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Changbin Tang, Li-Hua Yu, Duanduan Cui, Juanqin Xue, Xiangyang Yin, and Liu Zilong
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Materials science ,General Chemical Engineering ,chemistry.chemical_element ,engineering.material ,Anode ,Surface coating ,Coating ,Chemical engineering ,chemistry ,Electrode ,Electrochemistry ,engineering ,Surface roughness ,Surface layer ,Tin ,Titanium - Abstract
Ti/TiN/PbO2 electrodes were prepared using an arc-sprayed TiN interlayer on Ti substrates, followed by the anodic electrodeposition of a PbO2 catalytic surface layer on it. In order to investigate the positive effect of the TiN interlayer on the stability and electrocatalytic activity of the anodes, microstructural, surface roughness, adhesion evaluation, accelerated life and electrochemical performance tests and electrooxidation experiments of phenol simulated wastewater were conducted and compared with Ti/PbO2 anodes without the interlayer. The experimental results demonstrated that the arc-sprayed TiN interlayer with a thickness of 140–180 μm had a higher surface roughness and hardness than that of its titanium substrate. The coatings forming the electrode were firmly bonded to the substrate. The conductivity of the Ti-based PbO2 anode containing the TiN interlayer was significantly improved. The PbO2 surface coating achieved a faster deposition rate and finer grains, which produce a number of anode active sites and the electrocatalytic performance was boosted with a removal rate of phenol of up to 85.2%, which was higher than that of Ti/PbO2 by 30.6%. Simultaneously, the anode stability was also significantly enhanced, i.e., the Ti/TiN/PbO2 anode constructed by introducing the TiN interlayer exhibited excellent stability and electrocatalytic performance. The high-performance anode obtained relied not only on the presence of the arc-sprayed TiN interlayer, which significantly improved the overall physicochemical properties of the electrode, but also on the kinetic rate of the electrocrystallization growth of the refined PbO2 coating that was accelerated.
- Published
- 2021
31. Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice
- Author
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Chunhui Lang, Ni Tang, Xia-mao Liu, Xue-Fei Cai, Li-hua Yu, Zhijie Li, Jianglin Xiang, Li Wang, Zheng Zhou, Wen-Guang Tian, Yin-yin Xu, Fang Gong, Xiao Feng Li, Chang-chun Niu, Pu Liao, Ji-Hua Ren, Ailong Huang, Xiaojun Tang, Deqiang Wang, Yong Zhang, Cheng-jun Xue, Jin-jing Li, De-chun Zhang, Fan Zhang, Qin Li, Qing-jun Yang, Xianxiang Zhang, Bei-zhong Liu, Shao-bo Wu, Yong Lin, Kun Wang, Yuan Hu, Jing Wang, Xiaohe Luo, Liu Ping, Zhan Mo, Xiao-ping Cui, Quanxin Long, Jieli Hu, Haijun Deng, Yao-kai Chen, Xiao-li Zhang, Guicheng Wu, Huawen Liu, Jingfu Qiu, Juan Chen, and Hong-xin Du
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,biology ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Serology ,Titer ,Antibody response ,Internal medicine ,Cohort ,medicine ,biology.protein ,Seroconversion ,Antibody ,business - Abstract
BackgroundWe aim to investigate the profile of acute antibody response in COVID-19 patients, and provide proposals for the usage of antibody test in clinical practice.MethodsA multi-center cross-section study (285 patients) and a single-center follow-up study (63 patients) were performed to investigate the feature of acute antibody response to SARS-CoV-2. A cohort of 52 COVID-19 suspects and 64 close contacts were enrolled to evaluate the potentiality of the antibody test.ResultsThe positive rate for IgG reached 100% around 20 days after symptoms onset. The median day of seroconversion for both lgG and IgM was 13 days after symptoms onset. Seroconversion of IgM occurred at the same time, or earlier, or later than that of IgG. IgG levels in 100% patients (19/19) entered a platform within 6 days after seroconversion. The criteria of ‘IgG seroconversion’ and ‘> 4-fold increase in the IgG titers in sequential samples’ together diagnosed 82.9% (34/41) of the patients. Antibody test aided to confirm 4 patients with COVID-19 from 52 suspects who failed to be confirmed by RT-PCR and 7 patients from 148 close contacts with negative RT-PCR.ConclusionIgM and IgG should be detected simultaneously at the early phase of infection. The serological diagnosis criterion of seroconversion or the ‘>; 4-fold increase in the IgG titer’ is suitable for a majority of COVID-19 patients. Serologic test is helpful for the diagnosis of SARS-CoV-2 infection in suspects and close contacts.
- Published
- 2020
32. NSLS-II FOFB Performance Improvement in 2019
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Marshall Maggipinto, Xi Yang, Timur Shaftan, Yuke Tian, Danny Padrazo, Sukho Kongtawong, Kiman Ha, John Ricciardelli, and Li Hua Yu
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Computer science ,Performance improvement ,Simulation - Published
- 2019
33. First demonstration of the fast-to-slow corrector current shift in the NSLS-II storage ring
- Author
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Victor Smaluk, Yuke Tian, Xi Yang, and Li Hua Yu
- Subjects
Physics ,Nuclear and High Energy Physics ,Brightness ,Optics ,business.industry ,Orbit (dynamics) ,Photon beams ,Current (fluid) ,Orbit perturbation ,business ,Instrumentation ,Storage ring ,Beam (structure) - Abstract
To realize the full benefits of the high brightness and ultra-small beam sizes of NSLS-II, it is essential that the photon beams are exceedingly stable. In the circumstances of implementing local bumps, changing ID gaps, and long term drifting, the fast orbit feedback (FOFB) requires shifting the fast corrector strengths to the slow correctors to prevent the fast corrector saturation and to make the beam orbit stable in the sub-micron level. As the result, a reliable and precise technique of fast-to-slow corrector strength shift has been developed and tested at NSLS-II. This technique is based on the fast corrector response to the slow corrector change when the FOFB is on. In this article, the shift technique is described and the result of proof-of-principle experiment carried out at NSLS-II is presented. The maximum fast corrector current was reduced from greater than 0.45 A to less than 0.04 A with the orbit perturbation within ± 1 μ m.
- Published
- 2018
34. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver
- Author
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Zhen-Ping Zhu, Ning Zhao, Cui-Li Zhang, Min-Jie Guan, Tao Zeng, Rui Yang, Li-Hua Yu, Keqin Xie, Mo Xiao, and Xiulan Zhao
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0301 basic medicine ,Male ,Clinical Biochemistry ,PTEN, phosphatase and tensin homologue deleted on chromosome ten ,medicine.disease_cause ,Biochemistry ,PKB/Akt, protein kinase B ,Mice ,0302 clinical medicine ,CYP2E1, cytochrome P4502E1 ,AST, aspartate transaminase ,Phosphorylation ,Alcoholic fatty liver ,lcsh:QH301-705.5 ,NAC, N-acetyl-L-cysteine ,PPAR-γ, peroxisome proliferators- activated receptor γ ,lcsh:R5-920 ,biology ,TG, triglyceride ,Fatty liver ,Cytochrome P-450 CYP2E1 ,Hep G2 Cells ,PDK-1, phosphoinositide- dependent protein kinase 1 ,Insulin-like growth factor-1 ,Liver ,030220 oncology & carcinogenesis ,LPS, lipopolysaccharide ,PPAR-α, peroxisome proliferators-activated receptor α ,lcsh:Medicine (General) ,Research Paper ,Fatty Liver, Alcoholic ,medicine.medical_specialty ,ALD, alcoholic liver disease ,ALT, alanine transaminase ,SREBP-1c, sterol regulatory element-binding protein 1c ,AFL, alcoholic fatty liver ,IGF-1, insulin-like growth factor-1 ,NAFLD, non-alcoholic liver disease ,03 medical and health sciences ,ROS, reactive oxygen species ,PI3K, phosphatidylinositol 3 kinase ,Protein kinase B ,Internal medicine ,4-HNE, 4-hydroxynonenal ,medicine ,PTEN ,CMZ, chlormethiazole ,SIRT-1, sirtuin 1 ,Animals ,Humans ,Protein kinase A ,PI3K/AKT/mTOR pathway ,Cytochrome P4502E1 ,MDA, malondialdehyde ,Organic Chemistry ,medicine.disease ,AMPK, AMP-activated protein kinase ,Oxidative Stress ,030104 developmental biology ,Endocrinology ,lcsh:Biology (General) ,Chronic Disease ,biology.protein ,Cancer research ,Proto-Oncogene Proteins c-akt ,Oxidative stress - Abstract
Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment of Akt activity has been demonstrated to be involved in the development of non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that cytochrome P4502E1 (CYP2E1) plays causal roles in the pathogenesis of alcoholic fatty liver (AFL). We hypothesized that Akt activity might be impaired due to CYP2E1-induced oxidative stress in chronic ethanol-induced hepatic steatosis. In this study, we found that chronic ethanol-induced hepatic steatosis was accompanied with reduced phosphorylation of Akt at Thr308 in mice liver. Chronic ethanol exposure had no effects on the protein levels of phosphatidylinositol 3 kinase (PI3K) and phosphatase and tensin homologue deleted on chromosome ten (PTEN), and led to a slight decrease of phosphoinositide-dependent protein kinase 1 (PDK-1) protein level. Ethanol exposure resulted in increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)-Akt adducts, which was significantly inhibited by chlormethiazole (CMZ), an efficient CYP2E1 inhibitor. Interestingly, N-acetyl-L-cysteine (NAC) significantly attenuated chronic ethanol-induced hepatic fat accumulation and the decline of Akt phosphorylation at Thr308. In the in vitro studies, Akt phosphorylation was suppressed in CYP2E1-expressing HepG2 (CYP2E1-HepG2) cells compared with the negative control HepG2 (NC-HepG2) cells, and 4-HNE treatment led to significant decrease of Akt phosphorylation at Thr308 in wild type HepG2 cells. Lastly, pharmacological activation of Akt by insulin-like growth factor-1 (IGF-1) significantly alleviated chronic ethanol-induced fatty liver in mice. Collectively, these results indicate that CYP2E1-induced oxidative stress may be responsible for ethanol-induced suppression of Akt phosphorylation and pharmacological modulation of Akt in liver may be an effective strategy for the treatment of ethanol-induced fatty liver., Graphical abstract fx1
- Published
- 2018
35. Towards coherent X-ray free-electron lasers
- Author
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Timur Shaftan and Li Hua Yu
- Subjects
Free electron model ,Physics ,business.industry ,Bandwidth (signal processing) ,X-ray ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Laser ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,010309 optics ,Optics ,law ,0103 physical sciences ,High harmonic generation ,0210 nano-technology ,business ,Fermi Gamma-ray Space Telescope - Abstract
Increased bandwidth and fluctuations are hurdles on the path towards generating intense fully coherent X-ray free-electron laser output. A recent experiment at FERMI Trieste demonstrated that these difficulties can be overcome by an approach called echo-enabled harmonic generation.
- Published
- 2019
36. Estrogen receptor β alleviates inflammatory lesions in a rat model of inflammatory bowel disease via down-regulating P2X7R expression in macrophages
- Author
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Bei Ma, Yuchen Liu, Wenxin Li, Zhan-ying Lu, Xu Zhu, Li-ming Cheng, Qian Jiang, and Li-hua Yu
- Subjects
MAPK/ERK pathway ,Janus kinase 2 ,biology ,Chemistry ,Kinase ,Macrophages ,Estrogen receptor ,Inflammation ,Cell Biology ,Pharmacology ,Colitis ,CREB ,Biochemistry ,Rats ,Mice ,RAW 264.7 Cells ,biology.protein ,medicine ,Animals ,Estrogen Receptor beta ,medicine.symptom ,STAT3 ,Estrogen receptor beta - Abstract
Estrogen receptor beta (ERβ) agonists could inhibit inflammation in animal models of inflammatory bowel disease (IBD). However, the mechanism underlying such effect and the potential role of P2 × 7 receptor (P2X7R) remains unclear. In the present study, we examined whether the effect of ERβ activation in IBD rats was related to P2X7R. Overexpression of ERβ using a recombinant lentivirus in IBD rats improved the IBD-like symptoms, including weight loss, disease activity index (DAI) scores, and inflammatory responses. ERβ agonists DPN and ERB-041 attenuated P2X7R expression in macrophages from colitis rats and in a murine macrophage cell line (RAW264.7) in response to either lipopolysaccharide (LPS) or adenosine triphosphate (ATP). DPN and ERB-041 also blocked increased production of TNF-α, IL-6, and IL-1β in the rectocolon of colitis rats. The two ERβ agonists reversed LPS- and ATP-induced up-regulation of P2X7R and its downstream proteins, including NLRP3, ASC, caspase-1, and pro-IL-1β, in RAW264.7 cells. Also, in both the rectocolon of colitis rats and RAW264.7 cells, ERβ agonists reversed the up-regulation of extracellular regulated protein kinases (ERK), the Janus kinase 2 (JAK2), and signal transducer and activator of transcription 3 (STAT3), but not up-regulation of serine threonine kinase or cAMP-response element binding protein (CREB). Blockade of JAK2 or STAT3 phosphorylation significantly reduced the ability of DPN to down-regulate P2X7R expression and the ability of ERB-041 and DPN to inhibit IL-1β release from RAW264.7 cells. We found that ERβ and P2X7R co-localized in the macrophages of rat rectocolon and in RAW264.7 cells. Deletion of macrophages from colitis rats with clodronate abolished the inhibitory effect of DPN. These results suggest that ERβ plays an important anti-inflammatory role in IBD rats by down-regulating P2X7R expression and inhibiting IL-1β release from macrophages through the JAK2/STAT3 signaling pathway.
- Published
- 2021
37. Numerical simulation of NSLS-II fast orbit feedback system
- Author
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Li Hua Yu, Timur Shaftan, Sukho Kongtawong, Kiman Ha, Yuke Tian, Guimei Wang, and Xi Yang
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Physics ,Nuclear and High Energy Physics ,Matrix (mathematics) ,Upgrade ,Amplitude ,Computer simulation ,Position (vector) ,Control theory ,Physics::Accelerator Physics ,Time domain ,Orbit (control theory) ,Instrumentation ,Beam (structure) - Abstract
We discuss recent work on the construction of a numerical simulation of the fast orbit feedback system at NSLS-II. The simulation operates in the time domain and also includes the spatial domain, i.e. all beam position monitors (BPMs) and correctors. It can accept inputs of the real beam orbit and the measured orbit response matrix. It can also add errors to every stage of the calculation. We present methods to verify the simulation results by comparing the simulation results with experimental data collected at NSLS-II. The results are in very good agreement. The effects of errors from BPMs and correctors, as well as the amplitude of excitation, on the feedback performance, are also explored. This simulation can be used to predict the behavior and performance of the system for a future upgrade.
- Published
- 2021
38. Polysaccharides from loquat (Eriobotrya japonica) leaves: Impacts of extraction methods on their physicochemical characteristics and biological activities
- Author
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Fu, Yuan, primary, Li, Fen, additional, Ding, Ye, additional, Li, Hua-Yu, additional, Xiang, Xian-Rong, additional, Ye, Qiong, additional, Zhang, Jian, additional, Zhao, Li, additional, Qin, Wen, additional, Gan, Ren-You, additional, and Wu, Ding-Tao, additional
- Published
- 2020
- Full Text
- View/download PDF
39. Comparison of structural characteristics and bioactivities of polysaccharides from loquat leaves prepared by different drying techniques
- Author
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Fu, Yuan, primary, Feng, Kang-Lin, additional, Wei, Si-Yu, additional, Xiang, Xian-Rong, additional, Ding, Ye, additional, Li, Hua-Yu, additional, Zhao, Li, additional, Qin, Wen, additional, Gan, Ren-You, additional, and Wu, Ding-Tao, additional
- Published
- 2020
- Full Text
- View/download PDF
40. Structural characteristics, rheological properties, and biological activities of polysaccharides from different cultivars of okra (Abelmoschus esculentus) collected in China
- Author
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Nie, Xi-Rui, primary, Li, Hong-Yi, additional, Du, Gang, additional, Lin, Shang, additional, Hu, Rui, additional, Li, Hua-Yu, additional, Zhao, Li, additional, Zhang, Qing, additional, Chen, Hong, additional, Wu, Ding-Tao, additional, and Qin, Wen, additional
- Published
- 2019
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41. Fabrication of a stable Ti/Pb-TiOxNWs/PbO2 anode and its application in benzoquinone degradation
- Author
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Juanqin Xue, Changbin Tang, Li-Hua Yu, Lihua Zhang, and Yingjuan Guo
- Subjects
Materials science ,Passivation ,General Chemical Engineering ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,X-ray photoelectron spectroscopy ,Chemical engineering ,Titanium dioxide ,Linear sweep voltammetry ,Electrode ,Cyclic voltammetry ,0210 nano-technology ,Titanium - Abstract
To delay passivation of a titanium (Ti) substrate as well as enhance adhesion between an electrodeposited PbO2 coating and the Ti substrate, a titanium-lead composite oxide nanowire (Pb-TiOxNWs) intermediate layer was formed in situ on the surface of porous Ti by alkali etching, ion substitution, and high-temperature calcination. At the same time, Ti/PbO2 and Ti/TiO2NWs/PbO2 electrodes with porous Ti as a matrix were prepared for comparison. The surface structure and morphology of the prepared intermediate layer and the PbO2 coating were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The influences of the composite oxide intermediate layer on the electrochemical performance of the PbO2 electrode were analyzed by cyclic voltammetry (CV), linear sweep voltammetry (LSV), and AC impedance spectroscopy (EIS). Accelerated lifetime tests were performed for electrodes with and without different intermediate layers. The results showed that PbOx was incorporated into the titanium dioxide three-dimensional network structure, resulting in formation of Pb-TiOxNWs. The surface of the Ti/Pb-TiOxNWs/PbO2 electrode was denser due to the smaller particle size of PbO2. The preferred crystal orientation of β(110) was observed for PbO2 deposited on Ti/Pb-TiOxNWs. The oxygen evolution potential reached a maximum of 2.19 V for Ti/Pb-TiOxNWs/PbO2. Accelerated life tests showed that compared with Ti/PbO2 and Ti/TiO2NWs/PbO2, the electrode life of Ti/Pb-TiOxNWs/PbO2 was increased by 91.7% and 35.3%, respectively. Therefore, it can be concluded that significantly improved morphology and electrochemical performance were achieved for titanium-based PbO2 electrodes by the addition of a Pb-TiOxNWs intermediate layer. In particular, the electrochemical stability of the PbO2 coating electrodes was improved markedly by the Pb-TiOxNWs intermediate layer. The electrodes were used for electrochemical oxidation of benzoquinone in wastewater (100 mg/L). It was found that chloride ions played a critical role in improving the current efficiency of electro-oxidative degradation. Under the same conditions, the COD removal rate in the presence of NaCl was 45% higher than in the presence of sulfate. The results of HPLC analysis of the intermediate products indicated that the oxidants electro-generated by chloride ions had stronger ring-opening and mineralization capabilities than those electro-generated by sulfate ions.
- Published
- 2021
42. Efficacy of Modified Wuzhuyu Decoction Granule (加减吴茱萸汤 颗粒剂) for Migraine Patients with Cold and Stasis Obstructing Meridian Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
- Author
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Yong Zhang, Da-yong Ma, Ke-gang Cao, Yihuai Zou, Li-hua Yu, Hong-wei Liu, and Cai-hong Fu
- Subjects
medicine.medical_specialty ,Visual analogue scale ,business.industry ,Placebo-controlled study ,Decoction ,General Medicine ,Traditional Chinese medicine ,Placebo ,medicine.disease ,Surgery ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Meridian (perimetry, visual field) ,Complementary and alternative medicine ,Randomized controlled trial ,Migraine ,law ,Anesthesia ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,business ,030217 neurology & neurosurgery - Abstract
To study the efficacy of modified Wuzhuyu Decoction Granule (加减吴茱萸汤颗粒, MWDG) in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. This study was a randomized, double-blind, placebo-controlled trial. A total of 78 migraine patients with cold and stasis obstructing meridian syndrome were recruited and randomly assigned by a ratio of 2:1 into a treatment group (51 cases) and a placebo group (27 cases). Patients in the treatment group were treated with MWDG while placebo granules were applied in the control group. The treatment course lasted for 12 weeks with a follow-up of 4 weeks. The primary outcome measures included frequency and days of migraine attacks and the secondary outcome measures were analgesics consumption and visual analogue scale (VAS) scores. All outcome assessments were conducted respectively at baseline, the 4th, 8th and 12th week, and the end of follow-up. In the treatment group, significant decrease in frequency of migraine attacks were observed since the 4th week and that of analgesics consumption since the 8th week (both P 0.05). MWDG was probably effective in the treatment of migraine especially for alleviating pain intensity. Furthermore, MWDG could reduce the frequency of migraine attacks and analgesics consumption sooner than the placebo.
- Published
- 2017
43. Clinical significance of coagulation function combined with blood gas analysis and serum NT-proBNP detection in COPD patients
- Author
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Li-Hua Yu and Yong-Chang Wu
- Subjects
Blood gas analysis ,NT-proBNP ,D-D ,lcsh:R ,COPD ,lcsh:Medicine ,Coagulation function ,circulatory and respiratory physiology ,respiratory tract diseases - Abstract
Objective: To investigate the clinical significance of coagulation function, blood gas analysis and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level detection in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 98 cases of COPD patients were selected and divided per different disease courses. For COPD acute exacerbation (AECOPD) stage, 53 patients were selected and set as group A. 45 cases of COPD patients in COPD stable stage were set as group B, and 50 cases of healthy people who received physical examination in our hospital in the corresponding period were collected and set as healthy controls (group C). Levels of PT, APTT, TT, Fbg, D-D, PaCO2, PaO2 and serum NTproBNP in the whole 3 groups of patients were detected. Differences of index levels among the 3 groups and between before and after treatment in AECOPD patients were compared separately. The correlations of NT-proBNP, coagulation relevant indexes and arterial blood gas relevant indexes were analyzed. Results: (1) PT, APTT in group A and PT, APTT in group B were obviously longer than which in group C, and group A showed more significant variations. (2) Fbg, D-D, PaCO2 , NT-proBNP in group A and Fbg, D-D, PaCO2, NT-proBNP in group B were obviously higher than which in group C; But PaO2 in group A and PaO2 in group B were significantly lower than which in group C; Group A showed more significant variations. (3) After treatment, PT and APTT in AECOPD patients were shorter than which before treatment, Fbg, D-D, PaCO2 and NT-proBNP were lower than before treatment, but PaO2 was higher than before treatment. (4) TT in group A were significantly longer than in group C, and differences showed no significance on comparison of TT between patients of group A and B, B and C and within A before and after treatment. (5) NT-proBNP in COPD patients showed significantly positive correlation separately with APTT, Fbg, D-D and PaCO2, showed significantly negative correlation with PaO2, but showed no obvious correlation with PT. Conclusion: Coagulation function and blood gas analysis combined with serum NT-proBNP level detection could better judge the severity of COPD. It shows significant reference value on clinical diagnosis, disease monitoring and evaluation for COPD patients.
- Published
- 2017
44. Compound effects of inhaling pure oxygen and lifting height on ear baric function in a hypobaric chamber
- Author
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Dong-qing WEN, Xue-wen ZHENG, Gui-you WANG, Xiao-peng LIU, Wei-ru SHI, Li-hua YU, Zhao GU, Jian-bing WU, Li-hao XUE, and Jie WANG
- Subjects
lcsh:R5-920 ,questionaires ,lcsh:R ,otorhinolaryngologic diseases ,lcsh:Medicine ,barotrauma ,lcsh:Medicine (General) ,hearing test ,audiometry, pure-tone ,auditory threshold - Abstract
Objective To compare the ear baric function between 4000m altitude chamber test with inhaling air and 6900m altitude chamber test with inhaling pure oxygen. Methods Eleven healthy male volunteers attended two tests as two groups by self-comparison. As the air group the volunteers inhaled air at 4000m, while as the pure oxygen group they inhaled pure oxygen at 6900m altitude, and the time interval between the two tests was more than two weeks. During the test, the volunteers breathed air or pure oxygen at random for 1h, and then were exposed at a speed of 20m/s to the target altitude for 5min. Hereafter they were sent back to the ground at the same speed. The changes of subjective symptoms, degree of tympanic congestion, acoustic immitance index and pure-tone auditory threshold were recorded before and after the test. The acoustic impedance index and pure-tone threshold were statistically analyzed. Results Four volunteers (4 ears) in air group and 7 volunteers (7 ears) in pure oxygen group reported ear pain in altitude chamber exposures, respectively. The pain-triggering altitude was higher in the pure oxygen group. Immediately after tests, there were 3 (3 ears) and 5 volunteers (5 ears) with Ⅲ degree congestion of the tympanic membrane in the two groups respectively. Four volunteers (6 ears) developed gradually aggravated hemorrhages after altitude exposure. And the tympanic membrane congestion difference between groups was statistically significant at 3 and 24h after tests (P
- Published
- 2017
45. Theory of square matrix for nonlinear optimization, and application to NSLS-II
- Author
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Li Hua Yu, Lingyun Yang, and Yongjun Li
- Subjects
Physics ,Applied mathematics ,Square matrix ,Nonlinear programming - Published
- 2019
46. Study Results and Plans for Future Improvement of the NSLS-II FOFB System
- Author
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J. Ricciardelli, Li Hua Yu, Victor Smaluk, Yuke Tian, and Xi Yang
- Published
- 2018
47. Recent improvements in beam orbit feedback at NSLS-II
- Author
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Yuke Tian, Timur Shaftan, Kiman Ha, Sukho Kongtawong, Xi Yang, and Li Hua Yu
- Subjects
Physics ,Nuclear and High Energy Physics ,Optics ,business.industry ,Bandwidth (signal processing) ,Beam instability ,Vertical plane ,Synchrotron light source ,Latency (engineering) ,business ,Horizontal plane ,Instrumentation ,Transfer function - Abstract
This paper discusses improvements made to the fast orbit feedback (FOFB) system at NSLS-II in 2019. We first characterized the system by measuring the transfer function and the closed-loop gain of the system. We also constructed a model to predict the performance, which was based on physical behaviors. After finding and fixing the sources of the latency, we improved the closed-loop gain’s bandwidth from 250 Hz to 400 Hz in the horizontal plane and 250 Hz to 300 Hz in the vertical plane. The orbit beam instability improved by 30% and 10% in the horizontal and vertical planes, respectively.
- Published
- 2020
48. Effects of breathing mixed gas with oxygen in different concentrations on delayed otic barotrauma
- Author
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Dong-qing WEN, Zhao GU, Xue-wen ZHENG, Li-hua YU, Xiao-qin CHEN, Hua-jun XIAO, Xiao-peng LIU, Gui-you WANG, Li-hao XUE, Bin ZANG, and Jie WANG
- Subjects
lcsh:R5-920 ,hearing ,lcsh:R ,altitude chamber ,lcsh:Medicine ,sense organs ,lcsh:Medicine (General) ,delayed otic barotrauma ,ear baric function - Abstract
Objective To investigate the delayed changes in middle ear function and audition after rapid changes in ambient pressure while breathing mixed gas with oxygen in different concentrations. Methods Five healthy male subjects, sitting in the hypobaric chamber breathed pure oxygen, 60% oxygen-rich air, or air respectively, one hour before hypobaric chamber test. The interval of two tests was longer than two weeks. After 20m/s rapid changes in the ambient pressure, all the three groups were tested with subjective symptoms, degree of congestion, middle ear function and audition at four timing. Results Just after test, the amount of symptomatic ears were 8, 2 and 3 in pure oxygen group, 60% oxygen-rich air group and air group, respectively. Some subjects in pure oxygen group felt aural fullness and pain again 3 hours after tests. The amount of Ⅲ°congestion ears was 5, 2 and 3 in each group respectively with no congestion aggravation. The amount of ears with A type tympanogram was 5, 6 and 6 in each group respectively. The extraction ratio of tympanogram and acoustic reflex incomplete in all groups recovered gradually to the initial value without obviously delayed data rebound. The middle ear pressure and pure-tone threshold in subjects of pure oxygen group changed more obviously and recovered more slowly. Conclusion In hypobaric chamber test, the incidence of otic barotrauma may increase in those subjects breathing pure oxygen with symptoms aggravation and repetition within 24h. DOI: 10.11855/j.issn.0577-7402.2016.04.14
- Published
- 2016
49. Preparation of acylamino copper Phthalocyanine modified multiwalled carbon nanotubes thin films with oxygen plasma treatment
- Author
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Li-hua Yu, Rui Wang, and Lei Xu
- Subjects
Materials science ,Absorption spectroscopy ,Band gap ,Mechanical Engineering ,Doping ,Infrared spectroscopy ,02 engineering and technology ,Carbon nanotube ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,law.invention ,Chemical engineering ,Mechanics of Materials ,law ,Covalent bond ,Organic chemistry ,General Materials Science ,Fourier transform infrared spectroscopy ,Thin film ,0210 nano-technology - Abstract
Hybrid thin films based on multi-walled carbon nanotubes (MWCNTs) and acylamino copper phthalocyanine (AM-CuPc) were prepared with oxygen plasma treatment technology. The effect of doping ratio on the photoelectric property of the films was investigated. The structure and morphology were characterized by Fourier transformed infrared spectrometer (FTIR) and field emission scanning electron microscopy (FESEM). The functional composites exhibited excellent dispersing property and the covalent bonds were formed between MWCNT and AM-CuPc. The UV–vis absorption spectra showed the absorbility was improved. In addition, the band gap was affected by the doping ratio and it was minimum of 1.63 eV when the MWCNT-doping content was 40%. It will supply a new way to synthetize solar energy materials with different band gap.
- Published
- 2016
50. Preparation of MWCNTs/CuPc/Ag modified conductive polyester fiber with chemical liquid deposition
- Author
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Lei Xu, Qiang Tao, Li-hua Yu, and Rui Wang
- Subjects
Materials science ,chemistry.chemical_element ,02 engineering and technology ,Carbon nanotube ,engineering.material ,01 natural sciences ,law.invention ,X-ray photoelectron spectroscopy ,Coating ,law ,Electrical resistivity and conductivity ,0103 physical sciences ,Fiber ,Electrical and Electronic Engineering ,Composite material ,010302 applied physics ,Doping ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Polyester ,chemistry ,engineering ,0210 nano-technology ,Carbon - Abstract
Novel multi-walled carbon nanotubes (MWCNTs) and copper phthalocyanine (CuPc) modified conductive silver-plated fiber (MCA-fiber) was successfully prepared via chemical liquid deposition method with polyester as soft template. The structures and morphologies were characterized by X-ray photoelectron spectroscopy and field emission scanning electron microscopy. The binding energy of oxygen and carbon are 543, 296 eV respectively and the SEM images show CuPc and MWCNTs are deposited on the surface of silvered fiber continuously. The MCA-fiber is about 75 μm in diameter. The effect of process conditions on the properties of MCA-fiber was investigated. With the increasing of the concentration of AgNO3, the coating amount and electrical conductivity first increase and then decrease. The decrease of MWCNTs can bring down the electrical conductivity, but can improve the coating amount of materials on the surface of fibers. There is a sharp decrease from 7.20 × 10−4 to 1.33 × 10−4 s/cm when the MWCNT-doping content is 20 %. When the doping ratio of MWCNTs and CuPc is 2:8, the coating amount rises to 19.2 %. The mechanism study on the photovoltaic properties of MCA-fiber verifies that it can be used in fiber-shaped solar cells.
- Published
- 2015
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