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Your search keyword '"Li, Lianhong"' showing total 176 results
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176 results on '"Li, Lianhong"'

27. Additional file 2 of Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity

Author

Qin, Tao, Li, Bai, Feng, Xiaoyue, Fan, Shujun, Liu, Lei, Liu, Dandan, Mao, Jun, Lu, Ying, Yang, Jinfeng, Yu, Xiaotang, Zhang, Qingqing, Zhang, Jun, Song, Bo, Li, Man, and Li, Lianhong

Abstract

Figure S1. Protein level of OCT4 as detected by western blotting after the NC siRNA group or the USP37 siRNA#2 group was treated with 0.5 ��M purmorphamine for 48 h. GAPDH was examined as a loading control. (DOCX 80 kb)

Published
2021
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32. Annexin A1 is responsible for ursolic acid mediated anticancer effects on breast cancer stem cells by wnt/β-catenin pathway

Author

fan, shujun, primary, Xu, Ruixue, additional, Zhang, Han, additional, Mao, Jun, additional, Zhang, Qingqing, additional, Lu, Ying, additional, Wang, Mei, additional, Wang, Huaxin, additional, Yu, Xiaotang, additional, Hou, Zhenhuan, additional, Sun, Xu, additional, Wei, Yuanyi, additional, Huang, Yuhong, additional, Wang, Bo, additional, Song, Bo, additional, and Li, Lianhong, additional

Published
2020
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39. Additional file 2: of Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity

Author

Qin, Tao, Li, Bai, Feng, Xiaoyue, Fan, Shujun, Liu, Lei, Liu, Dandan, Mao, Jun, Lu, Ying, Yang, Jinfeng, Yu, Xiaotang, Zhang, Qingqing, Zhang, Jun, Song, Bo, Li, Man, and Li, Lianhong

Abstract

Figure�� S1. Protein level of OCT4 as detected by western blotting after the NC siRNA group or the USP37 siRNA#2 group was treated with 0.5 ����M purmorphamine for 48 h. GAPDH was examined as a loading control.�� (DOCX 80 kb)

Published
2018
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45. Clinical Efficacy and Safety of Aidi Injection Plus Docetaxel-Based Chemotherapy in Advanced Nonsmall Cell Lung Cancer: A Meta-Analysis of 36 Randomized Controlled Trials

Author

Xiao, Zheng, primary, Wang, Chengqiong, additional, Li, Lianhong, additional, Tang, Xuemei, additional, Li, Nana, additional, Li, Jing, additional, Chen, Ling, additional, Gong, Qihai, additional, Tang, Fushan, additional, Feng, Jihong, additional, and Li, Xiaofei, additional

Published
2018
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48. microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5

Author

Yu, Lihui, Lu, Ying, Han, Xiaocui, Zhao, Wenyue, Li, Jiazhi, Mao, Jun, Wang, Bo, Shen, Jie, Fan, Shujun, Wang, Lu, Wang, Mei, Li, Lianhong, Tang, Jianwu, and Song, Bo

Subjects
Male, microRNA-140-5p, Metastasis, Invasion, Cell Movement, Cell Line, Tumor, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, RNA, Small Interfering, Aged, Neoplasm Staging, Research, Middle Aged, HCT116 Cells, Colorectal cancer, digestive system diseases, Gene Expression Regulation, Neoplastic, MicroRNAs, Retraction Note, ADAMTS5, Disease Progression, Female, IGFBP5, ADAMTS5 Protein, Colorectal Neoplasms, Insulin-Like Growth Factor Binding Protein 5, Oligoribonucleotides, Antisense, Signal Transduction
Abstract

Background Colorectal cancer (CRC) is one of the most common malignancies in the world. microRNA-140-5p (miR-140) has been shown to be involved in cartilage development and osteoarthritis (OA) pathogenesis. Some contradictions still exist concerning the role of miR-140 in tumor progression and metastasis, and the underlying mechanism is uncertain. Methods Immunohistochemistry was performed to determine the expressions of ADAMTS5 and IGFBP5 in CRC tissues. Human CRC cell lines HCT116 and RKO were transfected with miR-140 mimic, inhibitor, or small interfering RNA (siRNA) against ADAMTS5 or IGFBP5, respectively, using oligofectamine or lipofectamine 2000. Scratch-wound assay and transwell migration and invasion assays were used to evaluate the effects of miR-140 on the capabilities of migration and invasion. The levels of miR-140 and ADAMTS5 and IGFBP5 mRNA were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Western blot was performed to examine the expression of ADAMTS5 and IGFBP5 proteins. Results miR-140 was significantly reduced, whereas ADAMTS5 and IGFBP5 were upregulated, in the human CRC tissues compared to the corresponding normal colorectal mucosa. miR-140 downregulation and ADAMTS5 or IGFBP5 overexpression were associated with the advanced TNM stage and distant metastasis of CRC. There was a reverse correlation between miR-140 levels and ADAMTS5 and IGFBP5 expression in CRC tissues. ADAMTS5 and IGFBP5 were downregulated by miR-140 at both the protein and mRNA levels in the CRC cell lines. The gain-of- and loss-of-function studies showed that miR-140 inhibited CRC cell migratory and invasive capacities at least partially via downregulating the expression of ADAMTS5 and IGFBP5. Conclusions These findings suggest that miR-140 suppresses CRC progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5. miR-140 might be a potential therapeutic candidate for the treatment of CRC.

Published
2016

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