Search

Your search keyword '"Li Petri, Sergio"' showing total 28 results
Start Over Author "Li Petri, Sergio" Publication Year Range Last 10 years
28 results on '"Li Petri, Sergio"'

6. Which Factors Are Associated with Distal Pancreatectomy Outcomes' Optimization with the Application of an Enhanced Recovery After Surgery Program?

Author

Pagano, Duilio, Li Petri, Sergio, di Francesco, Fabrizio, Calamia, Sergio, Accardo, Caterina, Vella, Ivan, Barbàra, Marco, and Gruttadauria, Salvatore

Abstract

Background: Distal pancreatectomy (DP) represents the best therapeutic option for patients with body-tail pancreatic neoplasms (PNs). The enhanced recovery after surgery protocol is widely used for treating patients with PN to speed up postoperative recovery. This study aims to describe our institute's experience in the application of fast recovery protocol in a cohort of patients treated with DP, identifying predictors facilitating a decrease in the length of hospital stay. Patient and Methods: Were retrospectively enrolled 60 consecutive cases of DP performed from January 2016 to June 2022 in patients treated with enhanced recovery protocol, 25% of them were treated with spleen preserving procedure. Single-variable logistic regression models were used to evaluate the potential association between patient characteristics and the probability of postoperative complications. Standard linear regression models were used for length of stay, number of postoperative days (PODs) from surgery to full bowel function recovery, and PODs to the interruption of intravenous analgesia administration. Results: Thirty-four (57%) patients underwent open surgery and 26 (43%) laparoscopic surgery. Patients who underwent laparoscopic surgery and spleen-preserving procedures experienced a lower complication rate (P = .037), shorter length of stay, and time of analgesic requirements. With single-variable logistic regression models patients treated with laparoscopic surgery had statistically significant higher recovery times in terms of nasogastric tube removal (P = .004) and early enteral nutrition (P = .001). Conclusion: Continual refinement with enhanced recovery protocol for treating PN patients based on perioperative counseling and surgical decision-making is crucial to reduce patient morbidity and time for recovery. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Impact of T Lymphocytes Isolated from Liver Perfusate of Deceased Brain Donors on Kidney Transplantation: Preliminary Evidence and Future Directions

Author

Pagano, Duilio, primary, Badami, Ester, additional, Zito, Giovanni, additional, Conaldi, Pier Giulio, additional, Vella, Ivan, additional, Buscemi, Barbara, additional, Amico, Giandomenico, additional, Busà, Rosalia, additional, Salis, Paola, additional, Li Petri, Sergio, additional, di Francesco, Fabrizio, additional, Calamia, Sergio, additional, Bonsignore, Pasquale, additional, Tropea, Alessandro, additional, Accardo, Caterina, additional, Piazza, Salvatore, additional, and Gruttadauria, Salvatore, additional

Published
2023
Full Text
View/download PDF

9. Impact on Kidney Transplantation of the Percentage of T Lymphocytes Isolated from Hepatic Perfusate of Multi-Organ Deceased Brain Donors

Author

Pagano, Duilio, primary, Badami, Ester, additional, Zito, Giovanni, additional, Conaldi, Pier Giulio, additional, Vella, Ivan, additional, Buscemi, Barbara, additional, Amico, Giandomenico, additional, Busà, Rosalia, additional, Salis, Paola, additional, Li Petri, Sergio, additional, Di Francesco, Fabrizio, additional, Calamia, Sergio, additional, Bonsignore, Pasquale, additional, Tropea, Alessandro, additional, Accardo, Caterina, additional, Piazza, Salvatore, additional, and Gruttadauria, Salvatore, additional

Published
2023
Full Text
View/download PDF

11. How important is the role of iterative liver direct surgery in patients with hepatocellular carcinoma for a transplant center located in an area with a low rate of deceased donation?

Author

Pagano, Duilio, Khouzam, Simone, Magro, Bianca, Barbara, Marco, Cintorino, Davide, di Francesco, Fabrizio, Li Petri, Sergio, Bonsignore, Pasquale, Calamia, Sergio, Deiro, Giacomo, Cammà, Calogero, Canzonieri, Marco, Gruttadauria, Salvatore, Pagano, Duilio, Khouzam, Simone, Magro, Bianca, Barbara, Marco, Cintorino, Davide, di Francesco, Fabrizio, Li Petri, Sergio, Bonsignore, Pasquale, Calamia, Sergio, Deiro, Giacomo, Camma', Calogero, Canzonieri, Marco, and Gruttadauria, Salvatore

Subjects
thermal ablation, Cancer Research, liver transplantation, Oncology, liver resection, hepatocellular carcinoma, laparoscopic
Abstract

IntroductionHepatocellular carcinoma (HCC) accounts for nearly 90% of primary liver cancers, with estimates of over 1 million people affected by 2025. We aimed to explore the impacting role of an iterative surgical treatment approach in a cohort of HCC patients within the Milan criteria, associated with clinical risk factors for tumor recurrence (RHCC) after liver transplant (LT) and loco-regional therapies (LRT), as well as liver resection (LR) and/or microwave thermal ablation (MWTA).MethodsWe retrospectively analyzed our experience performed during an 8-year period between January 2013 and December 2021 in patients treated for HCC, focusing on describing the impact on preoperative end-stage liver disease severity, oncologic staging, tumor characteristics, and surgical treatments. The Cox model was used to evaluate variables that could predict relapse risks. Relapse risk curves were calculated according to the Kaplan–Meier method, and the log-rank test was used to compare them.ResultsThere were 557 HCC patients treated with a first-line approach of LR and/or LRTs (n = 335) or LT (n = 222). The median age at initial transplantation was 59 versus 68 for those whose first surgical approach was LR and/or LRT. In univariate analysis with the Cox model, nodule size was the single predictor of recurrence of HCC in the posttreatment setting (HR: 1.61, 95% CI: 1.05–2.47, p = 0.030). For the LRT group, we have enlightened the following clinical characteristics as significantly associated with RHCC: hepatitis B virus infection (which has a protective role with HR: 0.34, 95% CI: 0.13–0.94, p = 0.038), number of HCC nodules (HR: 1.54, 95% CI: 1.22–1.94, p < 0.001), size of the largest nodule (HR: 1.06, 95% CI: 1.01–1.12, p = 0.023), serum bilirubin (HR: 1.57, 95% CI: 1.03–2.40, p = 0.038), and international normalized ratio (HR: 16.40, 95% CI: 2.30–118.0, p = 0.006). Among the overall 111 patients with RHCC in the LRT group, 33 were iteratively treated with further curative treatment (12 were treated with LR, two with MWTA, three with a combined LR-MWTA treatment, and 16 underwent LT). Only one of 18 recurrent patients previously treated with LT underwent LR. For these RHCC patients, multivariable analysis showed the protective roles of LT for primary RHCC after IDLS (HR: 0.06, 95% CI: 0.01–0.36, p = 0.002), of the time relapsed between the first and second IDLS treatments (HR: 0.97, 95% CI: 0.94–0.99, p = 0.044), and the impact of previous minimally invasive treatment (HR: 0.28, 95% CI: 0.08–1.00, p = 0.051).ConclusionThe coexistence of RHCC with underlying cirrhosis increases the complexity of assessing the net health benefit of ILDS before LT. Minimally invasive surgical therapies and time to HCC relapse should be considered an outcome in randomized clinical trials because they have a relevant impact on tumor-free survival.

Published
2022

12. The addition of simvastatin administration to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with a low rate of deceased donation: a monocentric randomized controlled double-blinded phase 2 study

Author

Pagano, Duilio, Oliva, Elisabetta, Khouzam, Simone, Tuzzolino, Fabio, Cintorino, Davide, Li Petri, Sergio, di Francesco, Fabrizio, Ricotta, Calogero, Bonsignore, Pasquale, Tropea, Alessandro, Calamia, Sergio, Costanzo, Federico, Luca, Angelo, and Gruttadauria, Salvatore

Published
2018
Full Text
View/download PDF

14. Donor Simvastatin Treatment Is Safe and Might Improve Outcomes After Liver Transplantation: A Randomized Clinical Trial

Author

Pagano, Duilio, primary, Bosch, Jaime, additional, Tuzzolino, Fabio, additional, Oliva, Elisabetta, additional, Ekser, Burcin, additional, Zito, Giovanni, additional, Cintorino, Davide, additional, di Francesco, Fabrizio, additional, Li Petri, Sergio, additional, Ricotta, Calogero, additional, Bonsignore, Pasquale, additional, Calamia, Sergio, additional, Magro, Bianca, additional, Trifirò, Gianluca, additional, Alduino, Rossella, additional, Barbara, Marco, additional, Conaldi, Pier Giulio, additional, Gallo, Alessia, additional, Venuti, Francesca, additional, Luca, Angelo, additional, and Gruttadauria, Salvatore, additional

Published
2022
Full Text
View/download PDF

17. Enhanced Recovery after Implementation of Surgery Protocol in Living Kidney Donors: The ISMETT Experience

Author

Ricotta, Calogero, primary, Cintorino, Davide, additional, Pagano, Duilio, additional, Bonsignore, Pasquale, additional, Piazza, Salvatore, additional, di Francesco, Fabrizio, additional, Li Petri, Sergio, additional, Tropea, Alessandro, additional, Calamia, Sergio, additional, Salis, Paola, additional, Luca, Angelo, additional, and Gruttadauria, Salvatore, additional

Published
2019
Full Text
View/download PDF

18. Impact of Italian Score for Organ Allocation System on Deceased Donor Liver Transplantation: A Monocentric Competing Risk Time-to-Event Analysis

Author

Khouzam, Simone, primary, Pagano, Duilio, additional, Barbàra, Marco, additional, Cintorino, Davide, additional, Li Petri, Sergio, additional, di Francesco, Fabrizio, additional, Ricotta, Calogero, additional, Bonsignore, Pasquale, additional, Seidita, Aurelio, additional, Calamia, Sergio, additional, Canzonieri, Marco, additional, Tropea, Alessandro, additional, and Gruttadauria, Salvatore, additional

Published
2019
Full Text
View/download PDF

19. Crucial Role of Extended Criteria Donors in Deceased Donor Single Kidney Transplantation to Face Chronic Shortage in the Heart of the Mediterranean Basin: A Single-Center Experience

Author

Bonsignore, Pasquale, primary, Pagano, Duilio, additional, Piazza, Salvatore, additional, Ricotta, Calogero, additional, di Francesco, Fabrizio, additional, Cintorino, Davide, additional, Li Petri, Sergio, additional, Canzonieri, Marco, additional, Tropea, Alessandro, additional, Calamia, Sergio, additional, Checchini, Giuliana, additional, Salis, Paola, additional, Arcadipane, Antonio, additional, Liotta, Rosa, additional, and Gruttadauria, Salvatore, additional

Published
2019
Full Text
View/download PDF

23. Preliminary Report on Introduction of Enhanced Recovery After Surgery Protocol for Laparoscopic Rectal Resection: A Single-Center Experience

Author

Cintorino, Davide, primary, Ricotta, Calogero, additional, Bonsignore, Pasquale, additional, Di Francesco, Fabrizio, additional, Li Petri, Sergio, additional, Pagano, Duilio, additional, Tropea, Alessandro, additional, Checchini, Giuliana, additional, Tuzzolino, Fabio, additional, and Gruttadauria, Salvatore, additional

Published
2018
Full Text
View/download PDF

27. Case report: Trans-papillary free stenting of the cystic duct and of the common bile duct in a double biliary ducts anastomoses of a right lobe living donor transplantation

Author

Alessandro Tropea, Salvatore Gruttadauria, Duilio Pagano, Sergio Calamia, Davide Cintorino, Sergio Li Petri, Fabrizio di Francesco, Pasquale Bonsignore, Calogero Ricotta, Gruttadauria, Salvatore, Tropea, Alessandro, Pagano, Duilio, Calamia, Sergio, Ricotta, Calogero, Bonsignore, Pasquale, Li Petri, Sergio, Cintorino, Davide, and di Francesco, Fabrizio

Subjects
Male, medicine.medical_specialty, Cirrhosis, medicine.medical_treatment, Biliary anastomoses, lcsh:Surgery, Anastomosis, Liver transplantation, Esophageal varices, Cholestasis, Liver Cirrhosis, Alcoholic, medicine, Living Donors, Humans, Common Bile Duct, Common bile duct, business.industry, Living donor liver transplantation, Anastomosis, Surgical, Cystic Duct, lcsh:RD1-811, General Medicine, Middle Aged, medicine.disease, Surgery, Liver Transplantation, Transplantation, medicine.anatomical_structure, Treatment Outcome, Cystic duct, Stents, Bile Ducts, business, Research Article
Abstract

Background One of the major issues related to the living donor liver transplantation recipient outcome is still the high rate of biliary complication, especially when multiple biliary ducts are present and multiple anastomoses have to be performed. Case presentation and conclusion We report a case of adult-to-adult right lobe living donor liver transplantation performed for a recipient affected by alcohol-related cirrhosis with MELD score of 17. End-stage liver disease was complicated by refractory ascites, portal hypertension, small esophageal varices and portal gastropathy, hypersplenism, and abundant right pleural effusion. Here in the attached video we described the adult-to-adult LDLT procedures, where a right lobe with two biliary ducts draining respectively the right anterior and the right posterior segments has been transplanted. LDLT required a biliary reconstruction using the native cystic and common bile ducts stented trans-papillary with two 5- French 6 cm long soft silastic catheter. None major complications were detected during post-operative clinical courses. Actually, the donor and the recipient are alive and well. The technique we describe in the video, allow to keep the biliary anastomoses protected and patent without having the risk of creating cholestasis and the need of invasive additional procedure. No living donor right lobe transplantation should be refused because of the presence of multiple biliary ducts.

Published
2020

28. Phases I-II Matched Case-Control Study of Human Fetal Liver Cell Transplantation for Treatment of Chronic Liver Disease.

Author

Pietrosi G, Vizzini G, Gerlach J, Chinnici C, Luca A, Amico G, D'Amato M, Conaldi PG, Li Petri S, Spada M, Tuzzolino F, Alio L, Schmelzer E, and Gridelli B

Subjects
Adult, Aged, Antigens, Differentiation metabolism, Case-Control Studies, Female, Fetal Tissue Transplantation, Fetus metabolism, Follow-Up Studies, Humans, Immunohistochemistry, Keratin-18 metabolism, Liver metabolism, Liver pathology, Liver Cirrhosis pathology, Male, Microscopy, Fluorescence, Middle Aged, Retrospective Studies, Severity of Illness Index, Waiting Lists, alpha-Fetoproteins metabolism, Liver Cirrhosis surgery, Liver Transplantation
Abstract

Fetal hepatocytes have a high regenerative capacity. The aim of the study was to assess treatment safety and clinical efficacy of human fetal liver cell transplantation through splenic artery infusion. Patients with end-stage chronic liver disease on the waiting list for liver transplantation were enrolled. A retrospectively selected contemporary matched-pair group served as control. Nonsorted raw fetal liver cell preparations were isolated from therapeutically aborted fetuses. The end points of the study were safety and improvement of the Model for End-Stage Liver Disease (MELD) and Child-Pugh scores. Nine patients received a total of 13 intrasplenic infusions and were compared with 16 patients on standard therapy. There were no side effects related to the infusion procedure. At the end of follow-up, the MELD score (mean ± SD) in the treatment group remained stable from baseline (16.0 ± 2.9) to the last observation (15.7 ± 3.8), while it increased in the control group from 15.3 ± 2.5 to 19 ± 5.7 (p = 0.0437). The Child-Pugh score (mean ± SD) dropped from 10.1 ± 1.5 to 9.1 ± 1.4 in the treatment group and increased from 10.0 ± 1.2 to 11.1 ± 1.6 in the control group (p = 0.0076). All treated patients with history of recurrent portosystemic encephalopathy (PSE) had no further episodes during 1-year follow-up. No improvement was observed in the control group patients with PSE at study inclusion. Treatment was considered a failure in six of the nine patients (three deaths not liver related, one liver transplant, two MELD score increases) compared with 14 of the 16 patients in the control group (six deaths, five of which were caused by liver failure, four liver transplants, and four MELD score increases). Intrasplenic fetal liver cell infusion is a safe and well-tolerated procedure in patients with end-stage chronic liver disease. A positive effect on clinical scores and on encephalopathy emerged from this preliminary study.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results