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Your search keyword '"Liu, Yan-Hong"' showing total 639 results
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639 results on '"Liu, Yan-Hong"'

10. Research Progress of Anti - Cavitation Coating Alloy Materials for Hydropower Machinery

Author

ZHANG Lin - hai, ZHOU Quan - min, WANG Xiao - jing, NING Jun, ZHENG Ming - min, LIU Yan - hong

Subjects
hydropower machinery, cavitation, coating, alloy material, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

As the cavitation is a long - term disturbing problem in hydropower industry, carrying out anti - cavitation research for hydropower machinery is of great significance for promoting hydropower development and scientific carbon reduction. In this work, the cavitation mechanism and prevention strategy for hydropower mechinery were briefly explained. Based on this, the current research status and application of anti - cavitation coating materials were emphatically discussed. Finally, the current problems and the future research direction of new anti - cavitation materials were prospected.

Published
2022
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17. Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.

Author

Cao, Ai-Ping, Wang, Yun-Ying, Shen, Yan-Yan, Liu, Yan-Hong, Liu, Jia-Yu, Wang, Yao, Guo, Yue, Wang, Rui-Bo, Xie, Bo-Yang, Pan, Xin, Li, Ai-Ling, Xia, Qing, Zhang, Wei-Na, and Zhou, Tao

Abstract

Dendritic cells (DCs) are crucial in initiating and shaping both innate and adaptive immune responses. Clinical studies and experimental models have highlighted their significant involvement in various autoimmune diseases, positioning them as promising therapeutic targets. Nicotinamide (NAM), a form of vitamin B3, with its anti-inflammatory properties, has been suggested, while the involvement of NAM in DCs regulation remains elusive. Here, through analyzing publicly available databases, we observe substantial alterations in NAM levels and NAM metabolic pathways during DCs activation. Furthermore, we discover that NAM, but not Nicotinamide Mononucleotide (NMN), significantly inhibits DCs over-activation in vitro and in vivo. The suppression of DCs hyperactivation effectively alleviates symptoms of psoriasis. Mechanistically, NAM impairs DCs activation through a Poly (ADP-ribose) polymerases (PARPs)-NF-κB dependent manner. Notably, phosphoribosyl transferase (NAMPT) and PARPs are significantly upregulated in lipopolysaccharide (LPS)-stimulated DCs and psoriasis patients; elevated NAMPT and PARPs expression in psoriasis patients correlates with higher psoriasis area and severity index (PASI) scores. In summary, our findings underscore the pivotal role of NAM in modulating DCs functions and autoimmune disorders. Targeting the NAMPT-PARP axis emerges as a promising therapeutic approach for DC-related diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Construction of Near-Infrared Probes with Remarkable Large Stokes Shift Based on a Novel Purine Platform for the Visualization of mtG4 Upregulation during Mitochondrial Disorder in Somatic Cells and Human Sperms

Author

Yu, Kang-Kang, Li, Kun, Wang, Hao-Yuan, Li, Xiao-Liang, Wu, Si-Xian, Xu, Wen-Ming, Liu, Yan-Hong, Wu, Chuan-Fang, Yu, Xiao-Qi, and Bao, Jin-Ku

Abstract

G-quadruplex structures within the nuclear genome (nG4) is an important regulatory factor, while the function of G4 in the mitochondrial genome (mtG4) still needs to be explored, especially in human sperms. To gain a better understanding of the relationship between mtG4 and mitochondrial function, it is crucial to develop excellent probes that can selectively visualize and track mtG4 in both somatic cells and sperms. Herein, based on our previous research on purine frameworks, we attempted for the first time to extend the conjugated structure from the C-8 site of purine skeleton and discovered that the purine derivative modified by the C-8 aldehyde group is an ideal platform for constructing near-infrared probes with extremely large Stokes shift (>220 nm). Compared with the compound substituted with methylpyridine (PAP), the molecule substituted with methylthiazole orange (PATO) showed better G4 recognition ability, including longer emission (∼720 nm), more significant fluorescent enhancement (∼67-fold), lower background, and excellent photostability. PATOexhibited a sensitive response to mtG4 variation in both somatic cells and human sperms. Most importantly, PATOhelped us to discover that mtG4 was significantly increased in cells with mitochondrial respiratory chain damage caused by complex I inhibitors (6-OHDA and rotenone), as well as in human sperms that suffer from oxidative stress. Altogether, our study not only provides a novel ideal molecular platform for constructing high-performance probes but also develops an effective tool for studying the relationship between mtG4 and mitochondrial function in both somatic cells and human sperms.

Published
2024
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42. Effects of hospital–community integrated transitional care on quality of life in patients with chronic obstructive pulmonary disease†

Author

Liu Min, Li Guo-Hong, and Liu Yan-Hong

Subjects
omaha system, transitional care, chronic obstructive pulmonary disease, quality of life, sf-36, telephone follow-up, Nursing, RT1-120
Abstract

To explore the effects of “hospital–community integrated transitional care” model on quality of life in patients with chronic obstructive pulmonary disease (COPD).

Published
2019
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