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15 results on '"Lodder, Johannes C."'

1. Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Author

Pandya, Nikhil J., Seeger, Christian, Babai, Norbert, Gonzalez-Lozano, Miguel A., Mack, Volker, Lodder, Johannes C., Gouwenberg, Yvonne, Mansvelder, Huibert D., Danielson, U. Helena, Li, Ka Wan, Heine, Martin, Spijker, Sabine, Frischknecht, Renato, and Smit, August B.

Published
2018
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2. Mice with megalencephalic leukoencephalopathy with cysts: A developmental angle

Author

Dubey, Mohit, Bugiani, Marianna, Ridder, Margreet C., Postma, Nienke L., Brouwers, Eelke, Polder, Emiel, Jacobs, Gerbren J., Baayen, Johannes C., Klooster, Jan, Kamermans, Maarten, Aardse, Romy, de Kock, Christiaan P. J., Dekker, Marien P., van Weering, Jan R. T., Heine, Vivi M., Abbink, Truus E. M., Scheper, Gert C., Boor, Ilja, Lodder, Johannes C., Mansvelder, Huibert D., and van der Knaap, Marjo S.

Published
2015
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3. Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Author

Pandya, Nikhil J, Seeger, Christian, Babai, Norbert, Gonzalez-Lozano, Miguel A, Mack, Volker, Lodder, Johannes C, Gouwenberg, Yvonne, Mansvelder, Huibert D., Danielson, U. Helena, Li, Ka Wan, Heine, Martin, Spijker, Sabine, Frischknecht, Renato, Smit, August B., Pandya, Nikhil J, Seeger, Christian, Babai, Norbert, Gonzalez-Lozano, Miguel A, Mack, Volker, Lodder, Johannes C, Gouwenberg, Yvonne, Mansvelder, Huibert D., Danielson, U. Helena, Li, Ka Wan, Heine, Martin, Spijker, Sabine, Frischknecht, Renato, and Smit, August B.

Abstract

Lateral diffusion on the neuronal plasma membrane of the AMPA-type glutamate receptor (AMPAR) serves an important role in synaptic plasticity. We investigated the role of the secreted glycoprotein Noelin1 (Olfactomedin-1 or Pancortin) in AMPAR lateral mobility and its dependence on the extracellular matrix (ECM). We found that Noelin1 interacts with the AMPAR with high affinity, however, without affecting rise- and decay time and desensitization properties. Noelin1 co-localizes with synaptic and extra-synaptic AMPARs and is expressed at synapses in an activity-dependent manner. Single-particle tracking shows that Noelin1 reduces lateral mobility of both synaptic and extra-synaptic GluA1-containing receptors and affects short-term plasticity. While the ECM does not constrain the synaptic pool of AMPARs and acts only extrasynaptically, Noelin1 contributes to synaptic potentiation by limiting AMPAR mobility at synaptic sites. This is the first evidence for the role of a secreted AMPAR-interacting protein on mobility of GluA1-containing receptors and synaptic plasticity.

Published
2018
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4. RNAi screening of subtracted transcriptomes reveals tumor suppression by taurine-activated GABAA receptors involved in volume regulation

Author

Wielders, Camiel L.C., van Nierop, Pim, Vormer, Tinke L., Foijer, Floris, Verheij, Joanne, Lodder, Johannes C., Andersen, Jesper B., Mansvelder, Huibert D., Te Riele, Hein, Wielders, Camiel L.C., van Nierop, Pim, Vormer, Tinke L., Foijer, Floris, Verheij, Joanne, Lodder, Johannes C., Andersen, Jesper B., Mansvelder, Huibert D., and Te Riele, Hein

Abstract

To identify coding and non-coding suppressor genes of anchorage-independent proliferation by efficient loss-of-function screening, we have developed a method for enzymatic production of low complexity shRNA libraries from subtracted transcriptomes. We produced and screened two LEGO (Low-complexity by Enrichment for Genes shut Off) shRNA libraries that were enriched for shRNA vectors targeting coding and non-coding polyadenylated transcripts that were reduced in transformed Mouse Embryonic Fibroblasts (MEFs). The LEGO shRNA libraries included ~25 shRNA vectors per transcript which limited off-target artifacts. Our method identified 79 coding and non-coding suppressor transcripts. We found that taurine-responsive GABAA receptor subunits, including GABRA5 and GABRB3, were induced during the arrest of non-transformed anchor-deprived MEFs and prevented anchorless proliferation. We show that taurine activates chloride currents through GABAA receptors on MEFs, causing seclusion of cell volume in large membrane protrusions. Volume seclusion from cells by taurine correlated with reduced proliferation and, conversely, suppression of this pathway allowed anchorage-independent proliferation. In human cholangiocarcinomas, we found that several proteins involved in taurine signaling via GABAA receptors were repressed. Low GABRA5 expression typified hyperproliferative tumors, and loss of taurine signaling correlated with reduced patient survival, suggesting this tumor suppressive mechanism operates in vivo.

Published
2018

6. Correction: The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

Author

Schmitz, Leanne J M, primary, Klaassen, Remco V, additional, Ruiperez-Alonso, Marta, additional, Zamri, Azra Elia, additional, Stroeder, Jasper, additional, Rao-Ruiz, Priyanka, additional, Lodder, Johannes C, additional, van der Loo, Rolinka J, additional, Mansvelder, Huib D, additional, Smit, August B, additional, and Spijker, Sabine, additional

Published
2018
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7. The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

Author

Schmitz, Leanne J M, primary, Klaassen, Remco V, additional, Ruiperez-Alonso, Marta, additional, Zamri, Azra Elia, additional, Stroeder, Jasper, additional, Rao-Ruiz, Priyanka, additional, Lodder, Johannes C, additional, van der Loo, Rolinka J, additional, Mansvelder, Huib D, additional, Smit, August B, additional, and Spijker, Sabine, additional

Published
2017
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9. Author response: The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

Author

Schmitz, Leanne J M, primary, Klaassen, Remco V, additional, Ruiperez-Alonso, Marta, additional, Zamri, Azra Elia, additional, Stroeder, Jasper, additional, Rao-Ruiz, Priyanka, additional, Lodder, Johannes C, additional, van der Loo, Rolinka J, additional, Mansvelder, Huib D, additional, Smit, August B, additional, and Spijker, Sabine, additional

Published
2017
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11. Author response: Unique membrane properties and enhanced signal processing in human neocortical neurons

Author

Eyal, Guy, primary, Verhoog, Matthijs B, additional, Testa-Silva, Guilherme, additional, Deitcher, Yair, additional, Lodder, Johannes C, additional, Benavides-Piccione, Ruth, additional, Morales, Juan, additional, DeFelipe, Javier, additional, de Kock, Christiaan PJ, additional, Mansvelder, Huibert D, additional, and Segev, Idan, additional

Published
2016
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13. Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Author

Klaassen, Remco V., primary, Stroeder, Jasper, additional, Coussen, Françoise, additional, Hafner, Anne-Sophie, additional, Petersen, Jennifer D., additional, Renancio, Cedric, additional, Schmitz, Leanne J. M., additional, Normand, Elisabeth, additional, Lodder, Johannes C., additional, Rotaru, Diana C., additional, Rao-Ruiz, Priyanka, additional, Spijker, Sabine, additional, Mansvelder, Huibert D., additional, Choquet, Daniel, additional, and Smit, August B., additional

Published
2016
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14. RNAi screening of subtracted transcriptomes reveals tumor suppression by taurine-activated GABAA receptors involved in volume regulation.

Author

Wielders, Camiel L. C., van Nierop, Pim, Vormer, Tinke L., Foijer, Floris, Verheij, Joanne, Lodder, Johannes C., Andersen, Jesper B., Mansvelder, Huibert D., and te Riele, Hein

Subjects
TUMOR suppressor genes, CELL proliferation, RNA, GABA, RNA interference, TRANSCRIPTOMES
Abstract

To identify coding and non-coding suppressor genes of anchorage-independent proliferation by efficient loss-of-function screening, we have developed a method for enzymatic production of low complexity shRNA libraries from subtracted transcriptomes. We produced and screened two LEGO (Low-complexity by Enrichment for Genes shut Off) shRNA libraries that were enriched for shRNA vectors targeting coding and non-coding polyadenylated transcripts that were reduced in transformed Mouse Embryonic Fibroblasts (MEFs). The LEGO shRNA libraries included ~25 shRNA vectors per transcript which limited off-target artifacts. Our method identified 79 coding and non-coding suppressor transcripts. We found that taurine-responsive GABAA receptor subunits, including GABRA5 and GABRB3, were induced during the arrest of non-transformed anchor-deprived MEFs and prevented anchorless proliferation. We show that taurine activates chloride currents through GABAA receptors on MEFs, causing seclusion of cell volume in large membrane protrusions. Volume seclusion from cells by taurine correlated with reduced proliferation and, conversely, suppression of this pathway allowed anchorage-independent proliferation. In human cholangiocarcinomas, we found that several proteins involved in taurine signaling via GABAA receptors were repressed. Low GABRA5 expression typified hyperproliferative tumors, and loss of taurine signaling correlated with reduced patient survival, suggesting this tumor suppressive mechanism operates in vivo. [ABSTRACT FROM AUTHOR]

Published
2018
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15. Mice with megalencephalic leukoencephalopathy with cysts: A developmental angle

Author

Dubey, Mohit, primary, Bugiani, Marianna, additional, Ridder, Margreet C., additional, Postma, Nienke L., additional, Brouwers, Eelke, additional, Polder, Emiel, additional, Jacobs, J. Gerbren, additional, Baayen, Johannes C., additional, Klooster, Jan, additional, Kamermans, Maarten, additional, Aardse, Romy, additional, de Kock, Christiaan P. J., additional, Dekker, Marien P., additional, van Weering, Jan R. T., additional, Heine, Vivi M., additional, Abbink, Truus E. M., additional, Scheper, Gert C., additional, Boor, Ilja, additional, Lodder, Johannes C., additional, Mansvelder, Huibert D., additional, and van der Knaap, Marjo S., additional

Published
2014
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