129 results on '"Longo J"'
Search Results
2. Perceived Susceptibility and Severity of COVID-19 on Prevention Practices, Early in the Pandemic in the State of Florida
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DeDonno, M. A., Longo, J., Levy, X., and Morris, J. D.
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- 2022
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3. Contributions of the lupus register of the Spanish Society of Rheumatology (RELESSER) to the knowledge of systemic lupus erythematosus in Spain
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López-Longo, J., Galindo-Izquierdo, M., Calvo-Alén, J., del Campo, V., Olivé-Marqués, A., Pérez-Vicente, S., Fernández-Nebro, A., Andrés, M., Erausquin, C., Tomero, E., Horcada, L., Uriarte, E., Freire, M., Montilla, C., Sánchez-Atrio, A., Santos, G., Boteanu, A., Díez-Álvarez, E., Narváez, J., Blanco-Alonso, R., Martínez-Taboada, V., Silva-Fernández, L., Ruiz-Lucea, E., Andreu, J.L., Hernández-Beriain, J.Á., Gantes, M., Hernández-Cruz, B., Pérez-Venegas, J., Rodríguez-Gómez, M., Zea, A., Fernández-Castro, M., Pecondón-Español, Á., Marras, C., Ibáñez-Barceló, M., Bonilla, G., Torrente-Segarra, V., Castellví, I., Alegre, J.J., Calvet, J., Marenco, J.L., Raya, E., Vázquez, T., Quevedo, V., Muñoz-Fernández, S., Ibáñez, J., Fernández-Berrizbeitia, O., Expósito, L., Carreira, P., Moreno, M., de la Peña, P.G., Aguirre, M.Á., Salman-Monte, T.C., Riveros Frutos, A., Tejera, B., Cobo-Ibañez, T., Sánchez-Alonso, F., Melero-González, R., Otón-Sánchez, T., García-Yebenes, M.J., Menor-Almagro, R., Mouriño, C., Fito-Manteca, C., Galisteo, C., Manero, J., Lois-Iglesias, A., Valls-Pascual, E., Manrique-Arija, S., Ucar, E., Borrell, H., Salgado, E., Rúa-Figueroa Fernández de Larrinoa, Iñigo, and Pego-Reigosa, José María
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- 2021
- Full Text
- View/download PDF
4. Aportaciones del registro de lupus de la Sociedad Española de Reumatología (RELESSER) al conocimiento del lupus eritematoso sistémico en España
- Author
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López-Longo, J., Galindo-Izquierdo, M., Calvo-Alén, J., del Campo, V., Olivé-Marqués, A., Pérez-Vicente, S., Fernández-Nebro, A., Andrés, M., Erausquin, C., Tomero, E., Horcada, L., Uriarte, E., Freire, M., Montilla, C., Sánchez-Atrio, A., Santos, G., Boteanu, A., Díez-Álvarez, E., Narváez, J., Blanco-Alonso, R., Martínez-Taboada, V., Silva-Fernández, L., Ruiz-Lucea, E., Andreu, J.L., Hernández-Beriain, J.Á., Gantes, M., Hernández-Cruz, B., Pérez-Venegas, J., Rodríguez-Gómez, M., Zea, A., Fernández-Castro, M., Pecondón-Español, Á., Marras, C., Ibáñez-Barceló, M., Bonilla, G., Torrente-Segarra, V., Castellví, I., Alegre, J.J., Calvet, J., Marenco, J.L., Raya, E., Vázquez, T., Quevedo, V., Muñoz-Fernández, S., Ibáñez, J., Fernández-Berrizbeitia, O., Expósito, L., Carreira, P., Moreno, M., de la Peña, P.G., Aguirre, M.Á., Salman-Monte, T.C., Riveros Frutos, A., Tejera, B., Cobo-Ibañez, T., Sánchez-Alonso, F., Melero-González, R., Otón-Sánchez, T., García-Yebenes, M.J., Menor-Almagro, R., Mouriño, C., Fito-Manteca, C., Galisteo, C., Manero, J., Lois-Iglesias, A., Valls-Pascual, E., Manrique-Arija, S., Ucar, E., Borrell, H., Salgado, E., Rúa-Figueroa Fernández de Larrinoa, Iñigo, and Pego-Reigosa, José María
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- 2021
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5. Mobilising Expertise and Resources to Close the Radiotherapy Gap in Cancer Care
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Rodin, D., Longo, J., Sherertz, T., Shah, M.M., Balagun, O., Wendling, N., Van Dyk, J., Coleman, C.N., Xu, M.J., and Grover, S.
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- 2017
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6. SoC It to EM: ElectroMagnetic Side-Channel Attacks on a Complex System-on-Chip
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Longo, J., De Mulder, E., Page, D., Tunstall, M., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Güneysu, Tim, editor, and Handschuh, Helena, editor
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- 2015
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7. Applied chemistry for the productive sector
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Benachi Osorio, Manuel Alejandro, Fabara Hernández, Karen Viviana, Escobar Narváez, Nicolás Mauricio, J., Galvez, Wagner, Elizabeth, Barrera, Diego, Ipia, Valentina, Cómbita Merchán, Diego Fernando, Marín Ocampo, Laura, Usma Valencia, Andrés Felipe, Zea Miranda, Rubén Valerio, Pérez Machado, Luis Felipe, Franco Montoya, Luz Natalia, Muñoz Gonzalez, Ana Maria, Gil Plazas, Andres Felipe, Rubiano, Julian David, Herrera Quintero, Liz Karen, Rodríguez Sandoval, Pedro, Medina Sánchez, Andrés Felipe, Oscar Eduardo, Ariza León, Pérez Peña, Olga Yurany, Sánchez Villamil, Carolina, Caro Laguna, Sergio, Amado Silva, Julian, Cáceres Bona, Brayan, Rincón Briceño, Diego, Losada Cañon, Merilin, Giraldo Galindo, Carlos Andres, Amado Garzón, Hamilton, Serrano Martin, Alison, Duarte Briceño, Paola, Herrrera Romero, Yesica Lorena, Urrea, Valentina, Niño Riveros, Carlos Hernando, Cuello Mejia, Dario Alfonso, Santos, D. S., Azevedo, R. B., Longo J., P. F., Pedraza Pachón, Sergio Alejandro, Sánchez, Magaly, López, Jiovanny, Álvarez, Adriana, García, Paula Juliana, Beltran Bautista, Santiago, Tiga Padilla, Isabel Sofía, Hernández Gómez, Yicely Katherine, Martínez, C., De La Rosa, D., Arzuaga, R., Parody, A., Jaramillo Echeverry, Lina María, Cifuentes Wchima, Ximena, Serna Jimenez, Johanna Andrea, Johan Manuel, Zuluaga, Sánchez, Leidy Camila, Ramirez Ramos, Gloria Consuelo, Espinel Calderón, Angie Carolina, Montoya Florez, Estefanny, Aponte Martinez, Anggi Paola, Pineda Bolivar, William, Gordillo Delgado, Fernando, Zuluaga Acosta, Jakeline, Marín Gallego, Benyi Juliana, Monclou Salcedo, Samuel Alejandro, Correa Torres, Sandra Natalia, Kopytko, María Irene, Vesga Guzmán, Diana Marcela, Herrera Barros, Adriana Patricia, Mazonas Vanegas, Rosa Valentina, Granados Torres, Valentina, Andrey Díaz, Santiago, Peña Díaz, Angela Marcela, Duque Álvarez, Brayan, Ramírez Navas, Juan Sebastián, Moreno Medina, Brigitte Liliana, Casierra Posada, Fanor, García Parra, Miguel Ángel, Hernández, Lubin Andres, Castrillón, Luvy Carolain, Manuel Ivan, Gómez Sánchez, Barragán Pérez, Andrea Liliana, Riveros, Raúl Alberto, Suarez Cely, Nubia Yohana, Jaramillo Loaiza, Akemy Sharise, Candamil Castaño, Alejandra, Jiménez Henao, Alex, Guacaneme Leguizamón, Alexander, Cuellar Burgos, Alneira, Romero Arroyave, Ana Lorena, Preciado, Andrea, Ruiz Márquez, Andrés Felipe, Mejía, Armando, Martínez, Bladimir, Ciprián, Brigitte, Valencia Eraso, Carlos David, German, Castro, Carreño, Catalina, Pássaro, Catarina, Mejía, Christian, Gámez Ávila, Cindy Carolina, Yepes Cartagena, Clara María, Cuellar, N., Martínez, Dan Daniel, Blanco Villadiego, Dialinis, Valencia, Diego Fernando, Aristizábal Buitrago, Diomer Hernán, Giraldo Bustamante, Dyro Alexis, Berrio Ortiz, Edinson, Velasco Molina, Edouard Frederic, Freyle Corro, Fabian Francisco, Mesa Rueda, Fabio Augusto, Aroca Bermeo, Faiber Andrey, Florez, A., Galvez, J., Taborda Ocampo, Gonzalo, Benites Cuellar, Harol Esneyder, Sánchez, Heidy Yuliana, Daza Lagos, Helena Victoria, Mojica, Jaquelin, Quintero Jaramillo, Javier Andres, Gil González, Jesús, Cardona Restrepo, Jhon Jairo, Rios Acevedo, Jhon Jairo, Gutiérrez Jiménez, Jhonier Stevens, Acosta, Johanna Marcela, García, John Alexander, Valencia Payán, Jonatan, Baeza Reyes, Jose Alejandro, Fuertes Muñoz, Jose Miguel, Rubio Rodríguez, Juan Alejandro, Avendaño Páez, Juan David, Monsalve, Juan Manuel, Quiceno, Juan Manuel, Medina, Juan Pablo, Siabato, Juan, Zapata, Julian, Guerra Galindo, Julieth Vanessa, Blanco Beltrán, Julio Gregorio, Tovar, Karen, Lancheros Cabra, Laura Valentina, Vega Rodríguez, Leidy Yaneth, Medina, Ligia, Almanza Mercado, Lilia Margarita, Olmos Blanquicett, Lisbeth Leticia, Cuellar Álvarez, Liseth Natalia, Lozano, Luis, Guzmán, Luis, Cardozo Ortiz, Maria del Mar, Betancur, María Isabel, Chaparro González, Maria Patricia, Páez, Melisa, Claro Vásquez, Miller Johanes, Alarcón Jiménez, Milton Fredy, Quintero, Mónica, Cadavid, Natalia, Charry Vargas, Natalia, Coneo Sandoval, Natalia, Abril, Nubia, Collazos, Oscar, Medina Vargas, Oscar Julio, Otálvaro, Angela, Valencia Osorio, Pablo, Vargas Moreno, Paola Andrea, Bedoya Cardona, Paula Natalia, Rey, Javier, Ayala Camargo, Rodrigo Francisco, Lozano Triana, Sandra Milena, Posso Cabrera, Santiago Evair, Altamar Perez, Teresa de Jesús, Torres, Valentina, González Castro, Valery Tatiana, Ramirez Salgado, Victor Manuel, Pérez Mora, Walter, Barragán Hernández, Wilson, Castro Escorcia, Yaceris Mercedes, Hernández Berrío, Yomaris del Carmen, Ramos Londoño, Yulieth Patricia, and Editorial Universidad EAN
- Subjects
Nanotecnología ,Química - Congresos, conferencias, etc ,Biotecnología ,Energías alternativas ,Ciencia y tecnología ,Química – Congresos, conferencias etc ,Fuentes renovables de energía ,Aprovechamiento de residuos - Abstract
Memorias del Primer Congreso Internacional de Química Aplicada al Sector Productivo 2018. El primer congreso Internacional de Química Aplicada al sector productivo Quindío 2018 se realizará en la ciudad de Armenia (Colombia) y se llevará a cabo en el Centro Cultural Metropolitano de Convenciones Quindío (Colombia). Para el desarrollo del presente evento se escogió como tema central “Aportes de la Química al Sector Cafetero” y pretende reunir grupos de investigación, semilleros e investigadores de diferentes instituciones de educación superior y/o empresas que podrán compartir los resultados finales o parciales de sus proyectos de investigación en el área de química aplicada al sector productivo. Finalmente, se buscará potenciar las habilidades y conocimientos necesarios para lograr una comunicación eficaz y valorar los trabajos científicos como elemento valioso para dinamizar la difusión científica. Dada la importancia en el sector productivo este primer congreso pretende brindar un espacio para divulgar los avances tecnológicos en temáticas de interés tales como: agroindustrial, alimentos, ambiental, formación, materiales y energías alternativas de importancia para la industria y sus procesos productivos. Universidad EAN Memories of the First International Congress of Chemistry Applied to the Productive Sector 2018. The first International Congress of Applied Chemistry to the productive sector Quindío 2018 will be held in the city of Armenia (Colombia) and will be held at the Centro Cultural Metropolitano de Convenciones Quindío (Colombia). For the development of this event was chosen as the central theme "Contributions of Chemistry to the Coffee Sector" and aims to bring together research groups, seedbeds and researchers from different higher education institutions and / or companies that will be able to share the final or partial results of their research projects in the area of chemistry applied to the productive sector. Finally, it will seek to enhance the skills and knowledge necessary to achieve effective communication and value scientific work as a valuable element to boost scientific dissemination. Given the importance in the productive sector, this first congress aims to provide a space to disseminate technological advances in topics of interest such as: agro-industrial, food, environmental, training, materials and alternative energies of importance for the industry and its production processes.
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- 2021
8. Contributions of the lupus register of the Spanish Society of Rheumatology (RELESSER) to the knowledge of systemic lupus erythematosus in Spain
- Author
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Rúa-Figueroa Fernández de Larrinoa, Iñigo, primary, Pego-Reigosa, José María, additional, López-Longo, J., additional, Galindo-Izquierdo, M., additional, Calvo-Alén, J., additional, del Campo, V., additional, Olivé-Marqués, A., additional, Pérez-Vicente, S., additional, Fernández-Nebro, A., additional, Andrés, M., additional, Erausquin, C., additional, Tomero, E., additional, Horcada, L., additional, Uriarte, E., additional, Freire, M., additional, Montilla, C., additional, Sánchez-Atrio, A., additional, Santos, G., additional, Boteanu, A., additional, Díez-Álvarez, E., additional, Narváez, J., additional, Blanco-Alonso, R., additional, Martínez-Taboada, V., additional, Silva-Fernández, L., additional, Ruiz-Lucea, E., additional, Andreu, J.L., additional, Hernández-Beriain, J.Á., additional, Gantes, M., additional, Hernández-Cruz, B., additional, Pérez-Venegas, J., additional, Rodríguez-Gómez, M., additional, Zea, A., additional, Fernández-Castro, M., additional, Pecondón-Español, Á., additional, Marras, C., additional, Ibáñez-Barceló, M., additional, Bonilla, G., additional, Torrente-Segarra, V., additional, Castellví, I., additional, Alegre, J.J., additional, Calvet, J., additional, Marenco, J.L., additional, Raya, E., additional, Vázquez, T., additional, Quevedo, V., additional, Muñoz-Fernández, S., additional, Ibáñez, J., additional, Fernández-Berrizbeitia, O., additional, Expósito, L., additional, Carreira, P., additional, Moreno, M., additional, de la Peña, P.G., additional, Aguirre, M.Á., additional, Salman-Monte, T.C., additional, Riveros Frutos, A., additional, Tejera, B., additional, Cobo-Ibañez, T., additional, Sánchez-Alonso, F., additional, Melero-González, R., additional, Otón-Sánchez, T., additional, García-Yebenes, M.J., additional, Menor-Almagro, R., additional, Mouriño, C., additional, Fito-Manteca, C., additional, Galisteo, C., additional, Manero, J., additional, Lois-Iglesias, A., additional, Valls-Pascual, E., additional, Manrique-Arija, S., additional, Ucar, E., additional, Borrell, H., additional, and Salgado, E., additional
- Published
- 2021
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9. Aportaciones del registro de lupus de la Sociedad Española de Reumatología (RELESSER) al conocimiento del lupus eritematoso sistémico en España
- Author
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Rúa-Figueroa Fernández de Larrinoa, Iñigo, primary, Pego-Reigosa, José María, additional, López-Longo, J., additional, Galindo-Izquierdo, M., additional, Calvo-Alén, J., additional, del Campo, V., additional, Olivé-Marqués, A., additional, Pérez-Vicente, S., additional, Fernández-Nebro, A., additional, Andrés, M., additional, Erausquin, C., additional, Tomero, E., additional, Horcada, L., additional, Uriarte, E., additional, Freire, M., additional, Montilla, C., additional, Sánchez-Atrio, A., additional, Santos, G., additional, Boteanu, A., additional, Díez-Álvarez, E., additional, Narváez, J., additional, Blanco-Alonso, R., additional, Martínez-Taboada, V., additional, Silva-Fernández, L., additional, Ruiz-Lucea, E., additional, Andreu, J.L., additional, Hernández-Beriain, J.Á., additional, Gantes, M., additional, Hernández-Cruz, B., additional, Pérez-Venegas, J., additional, Rodríguez-Gómez, M., additional, Zea, A., additional, Fernández-Castro, M., additional, Pecondón-Español, Á., additional, Marras, C., additional, Ibáñez-Barceló, M., additional, Bonilla, G., additional, Torrente-Segarra, V., additional, Castellví, I., additional, Alegre, J.J., additional, Calvet, J., additional, Marenco, J.L., additional, Raya, E., additional, Vázquez, T., additional, Quevedo, V., additional, Muñoz-Fernández, S., additional, Ibáñez, J., additional, Fernández-Berrizbeitia, O., additional, Expósito, L., additional, Carreira, P., additional, Moreno, M., additional, de la Peña, P.G., additional, Aguirre, M.Á., additional, Salman-Monte, T.C., additional, Riveros Frutos, A., additional, Tejera, B., additional, Cobo-Ibañez, T., additional, Sánchez-Alonso, F., additional, Melero-González, R., additional, Otón-Sánchez, T., additional, García-Yebenes, M.J., additional, Menor-Almagro, R., additional, Mouriño, C., additional, Fito-Manteca, C., additional, Galisteo, C., additional, Manero, J., additional, Lois-Iglesias, A., additional, Valls-Pascual, E., additional, Manrique-Arija, S., additional, Ucar, E., additional, Borrell, H., additional, and Salgado, E., additional
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- 2021
- Full Text
- View/download PDF
10. Preterm Birth at the Community University Hospital Center (Central African Republic)
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Koirokpi, A., primary, Wongo, G. R. D. L. Kogboma, additional, Ngbale, N. R., additional, Ouapou, S., additional, Matoulou-Mbala-Wa-Ngogbe, S., additional, Mballa, W. H. Komaria, additional, Longo, J. D. D., additional, and Sepou, A., additional
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- 2020
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11. Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats
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Aragón-Herrera A, Feijóo-Bandín S, Otero Santiago M, Barral L, Campos-Toimil M, Gil-Longo J, Costa Pereira TM, García-Caballero T, Rodríguez-Segade S, Rodríguez J, Tarazón E, Roselló-Lletí E, Portolés M, Gualillo O, González-Juanatey JR, and Lago F
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Ceramides, Empagliflozin, Glycerophospholipids, Heart, Metabolomics, Sphingolipids - Abstract
The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial made evident the potentiality of pharmacological sodium-glucose cotransporter 2 (SGLT2) inhibition for treating patients with diabetes and cardiovascular disease. Since the effect of empagliflozin or other SGLT2 inhibitors on the whole cardiac metabolic profile was never analysed before, and with the purpose to contribute to elucidate the benefits at cardiac level of the use of empagliflozin, we explored the effect of the treatment with empagliflozin for six weeks on the cardiac metabolomic profile of Zucker diabetic fatty rats, a model of early stage T2DM, using untargeted metabolomics approach. Empagliflozin reduced significantly the cardiac content of sphingolipids (ceramides and sphingomyelins) and glycerophospholipids (major bioactive contributing factors linking insulin resistance to cardiac damage) and decreased the cardiac content of the fatty acid transporter cluster of differentiation 36 (CD36); induced significant decreases of the cardiac levels of essential glycolysis intermediaries 2,3-bisphosphoglycerate and phosphoenolpyruvate, and regulated the abundance of several amino acids of relevance as tricarboxylic acid suppliers and/or in the metabolic control of the cardiac function as glutamic acid, gamma-aminobutyric acid and sarcosine. Empagliflozin treatment activated the cardioprotective master regulator of cellular energyhomeostasis AMP-activatedproteinkinase (AMPK) and enhanced autophagy at cardiac level, while it decreased significantly the cardiac mRNA levels of the pro-inflammatory cytokines interleukin-6 (IL-6), chemerin, TNF-a and MCP-1, reinforcing the hypothesis of a direct role for empagliflozin in attenuating cardiac inflammation. Our results provide an advancement on the knowledge of the mechanisms linking the therapy with empagliflozin with protective effects on the development of cardiometabolic diseases whose course is associated with remarkable cardiac bioenergetics dysregulation and disarrangement in cardiac metabolome and lipidome.
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- 2019
12. 17-2 - Facteurs associés au retard de diagnostic de la tuberculose pulmonaire à bacilloscopie positive à Bangui, Centrafrique
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Woromogo, S.H., De Dieu Longo, J., Saint Calvaire Diemer, H., and Grezenguet, G.
- Abstract
Un cas de tuberculose pulmonaire bactériologiquement confirmée (TPB+) non traitée, constitue un réservoir pour la transmission de la maladie. Cette étude avait pour objectif d’évaluer le délai et d'identifier les déterminants du retard diagnostic de la TPB+ dans les centres de diagnostic et de traitement de la tuberculose (CDT) à Bangui.
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- 2024
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13. Measurement of tau polarisation in Z/gamma* -> tau tau decays in proton-proton collisions at root s=8 TeV with the ATLAS detector
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Aaboudd, M, Aad, G, Abbott, B, Abdinov, O, Abeloos, B, Abidi, SH, AbouZeid, OS, Abraham, NL, Abrainowicz, H, Abreu, H, Abreu, R, Abulaiti, Y, Acharya, BS, Adachi, S, Adamczykh, L, Adelmanlm, J, Adersberger, M, Adye, T, Affolder, AA, Afik, Y, Agatonovic-Jovin, T, Agheorghiesei, C, Aguilar-Saavedra, JA, Ahlen, SP, Ahmadov, E, Aielli, G, Akatsuka, S, Akerstedt, H, Akesson, TPA, Akilli, E, Akimov, AV, Alberghi, GL, Albert, J, Albicocco, P, Alconada Verzini, MJ, Alderweireldt, SC, Aleksa, M, Aleksandrov, IN, Alexa, C, Alexander, G, Alexopoulos, T, Alhroob, M, Ali, B, Aliev, M, Alimonti, G, Alison, J, Alkire, SP, Allbrooke, BMM, Allen, BW, Allport, PP, Aloisio, A, Alonso, A, Alonso, F, Alpigiani, C, Alshehri, AA, Alstaty, MI, Alvarez Gonzalez, B, Alvarez Piqueras, D, Alviggi, MG, Amadio, BT, Coutinho, Y Amaral, Amelung, C, Amidei, D, Amor Dos Santos, SP, Amoroso, S, Amundsen, G, Anastopoulos, C, Ancu, LS, Andari, N, Andeen, T, Anders, CF, Anders, JK, Anderson, KJ, Andreazza, A, Andrei, V, Angelidakis, S, Angelozzi, I, Angerami, A, Anisenkov, AV, Anjos, N, Annovi, A, Antel, C, Antonelli, M, Antonov, A, Antrim, DJ, Anulli, F, Aoki, M, Aperio Bella, L, Arabidze, G, Arai, Y, Araquea, JP, Araujo Ferraz, V, Arce, ATH, Ardell, RE, Arduh, FA, Arguin, J-F, Argyropoulos, S, Arik, M, Armbruster, AJ, Armitage, LJ, Arnaez, O, Arnold, H, Arratia, M, Arslan, O, Artamonov, A, Artoni, G, Artz, S, Asai, S, Asbah, N, Ashkenazi, A, Asquith, L, Assamagan, K, Astalos, R, Atkinson, M, Atlay, NB, Augsten, K, Avolio, G, Axen, B, Ayoub, MK, Azuelos, G, Baas, AE, Baca, MJ, Bachacou, H, Bachas, K, Backes, M, Bagnaia, P, Bahmani, M, Bahrasemani, H, Baines, JT, Bajic, M, Baker, OK, Bakker, RJ, Baldin, EM, Balek, P, Balli, F, Balunas, WK, Banas, E, Bandyopadhyay, A, Banerjee, Sw, Bannoura, AAE, Barak, L, Barberio, EL, Barberis, D, Barbero, M, Barillari, T, Barisits, M-S, Barkeloo, JT, Barklow, T, Barlow, N, Barnes, SL, Barnett, BM, Barnett, RM, Barnovska-Blenessy, Z, Baroncelli, A, Barone, G, Barr, AJ, Banana Navarro, L, Barreiro, F, Barreiro Guimaraes da Costa, J, Bartoldus, R, Barton, AE, Banos, R, Basalaev, A, Bassalat, A, Bates, RL, Batlet, SJ, Batley, JR, Battaglia, M, Bauce, M, Bauer, F, Bawa, HS, Beacham, J, Beattie, MD, Beau, T, Beauchemin, PH, Bechtle, P, Beck, HP, Beck, HC, Becker, K, Becker, M, Becot, C, Beddall, AJ, Beddall, A, Bednyakov, VA, Bedognetti, M, Bee, CP, Beermann, TA, Begalli, M, Begel, M, Behr, JK, Bell, AS, Bella, G, Bellagamba, L, Bellerive, A, Bellomo, M, Belotskiy, K, Beltramello, O, Belyaev, NL, Benary, O, Benchekroun, D, Bender, M, Benekos, N, Benhammou, Y, Noccioli, E Benhar, Benitez, J, Benjamin, DP, Benoit, M, Bensinger, JR, Bentvelsen, S, Beresford, L, Beretta, M, Berge, D, Kuutmann, E Bergeaas, Berger, N, Beringer, J, Berlendis, S, Bernard, NR, Bernardi, G, Bernius, C, Bernlochner, FU, Berry, T, Berta, P, Bertella, C, Bertoli, G, Bertram, IA, Bertsche, C, Bertsche, D, Besjes, GJ, Bylund, O Bessidskaia, Bessner, M, Besson, N, Bethani, A, Bethke, 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Zimmermann, S, Zinonos, Z, Zinser, M, Ziolkowski, M, Zivkovic, L, Zobernig, G, Zoccoli, A, Zou, R, zur Nedden, M, Zwalinski, L, and Collaboration, ATLAS
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High Energy Physics::Phenomenology ,High Energy Physics::Experiment ,Nuclear Experiment - Abstract
This paper presents a measurement of the polarisation of τ leptons produced in Z/γ∗→ττ decays which is performed with a dataset of proton—proton collisions at s√=8 TeV, corresponding to an integrated luminosity of 20.2 fb −1 recorded with the ATLAS detector at the LHC in 2012. The Z/γ∗→ττ decays are reconstructed from a hadronically decaying τ lepton with a single charged particle in the final state, accompanied by a τ lepton that decays leptonically. The τ polarisation is inferred from the relative fraction of energy carried by charged and neutral hadrons in the hadronic τ decays. The polarisation is measured in a fiducial region that corresponds to the kinematic region accessible to this analysis. The τ polarisation extracted over the full phase space within the Z/γ∗ mass range of 66
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- 2018
14. Measurement of τ polarisation in Z/γ* → τ τ decays in proton–proton collisions at √s = 8 TeV with the ATLAS detector
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A, Saraiva, JG, Sarrazin, B, Sasaki, O, Sato, K, Sauvan, E, Savage, G, Savard, P, Savic, N, Sawyer, C, Sawyer, L, Saxon, J, Sbarra, C, Sbrizzi, A, Scanlon, T, Scannicchio, DA, Schaarschmidt, J, Schacht, P, Schachtner, BM, Schaefer, D, Schaefer, L, Schaefer, R, Schaeffer, J, Schaepe, S, Schaeizel, S, Schafer, U, Schaffer, AC, Schaile, D, Schamberger, RD, Schegelsky, VA, Scheirich, D, Schernau, M, Schiavi, C, Schier, S, Schildgen, LK, Schillo, C, Schiopp, M, Schlenker, S, Schmidt-Sommerfed, KR, Schmieden, K, Schmitt, C, Schmitt, S, Schmitz, S, Schnoor, U, Schoeffel, L, Schoening, A, Schoenrock, BD, Schopf, E, Schott, M, Schouwenberg, JFP, Schovancova, J, Schramm, S, Schuh, N, Schulte, A, Schultens, MJ, Schultz-Coulon, H-C, Schulz, H, Schumacher, M, Schumm, B, Schune, P, Schwartzman, A, Schwarz, TA, Schweiger, H, Schwemling, P, Schwienhorst, R, Schwindling, J, Sciandra, A, Sciolla, G, Scornajenghi, M, Scuri, F, Scutti, F, Searcy, J, Seema, P, Seidel, SC, Seiden, A, Seixas, JM, 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Smith, MNK, Smith, RW, Smizanska, M, Smolek, K, Snesarev, AA, Snyder, IM, Snyder, S, Sobie, R, Socher, F, Soffer, A, Sogaard, A, Soh, DA, Sokhrannyi, G, Sanchez, CAS, Solar, M, Soldatov, EY, Soldevila, U, Solodkov, AA, Soloshenko, A, Solovyanov, V, Solovyev, V, Sommer, P, Son, H, Sopczak, A, Sosa, D, Sotiropoulou, CL, Sottocornola, S, Soualah, R, Soukharev, AM, South, D, Sowden, BC, Spagnolo, S, Spalla, M, Spangenberg, M, Spano, F, Sperlich, D, Spettel, F, Spieker, TM, Spighi, R, Spigo, G, Spiller, LA, Spousta, M, Denis, RDS, Stabile, A, Stamenwa, R, Stamm, S, Stanecka, E, Stanek, RW, Stanescu, C, Stanitzki, MM, Stapf, BS, Stapnes, S, Starchenko, EA, Stark, GH, Stark, J, Stark, SH, Staroba, P, Starovoitov, P, Starz, S, Staszewski, R, Stegler, M, Steinberg, R, Stelzer, B, Stelzer, HJ, Stelzer-Chilton, O, Stenzel, H, Stevenson, TJ, Stewart, GA, Stockton, MC, Stoebe, M, Stoicea, G, Stolte, P, Stonjek, S, Stradling, AR, Straessner, A, Stramaglia, ME, Strandberg, J, Strandberg, S, Strauss, M, Strizenec, P, Strohmer, R, Strom, DM, Stroynowski, R, Strubig, A, Stucci, SA, Stugu, B, Styles, NA, Su, D, Su, J, Suchek, S, Sugaya, Y, Suk, M, Sulin, VV, Sultan, DMS, Sultansoy, S, Sumida, T, Sun, S, Sun, X, Suruliz, K, Suster, CJE, Sutton, MR, Suzuki, S, Svatos, M, Swiadowski, M, Swift, SP, Sykora, I, Sykora, T, Ta, D, Tackmann, K, Taenzer, J, Tallard, A, Tatirout, R, Tahirovic, E, Taiblum, N, Takai, H, Takashima, R, Takasugi, EH, Takeda, K, 'Fakeshita, T, Takubo, Y, Talby, M, Talyshev, AA, Tanaka, J, Tanaka, M, Tanaka, R, Tanaka, S, Tanioka, R, Tannenwald, BB, Araya, ST, Tapprogge, S, Tarem, S, Tartarelli, GF, Tas, P, Tasevsky, M, Tashiro, T, Tassi, E, Delgado, AT, Tayalati, Y, Taylor, AC, Taylor, AJ, Taylor, GN, Taylor, PTE, Taylor, W, Teixeira-Dias, P, Temple, D, Ten Kate, H, Teng, PK, Teohi, JJ, Tepel, F, Terada, S, Terashi, K, Terron, J, Terzo, S, Testa, M, Teuscher, RJ, Thais, SJ, Theveneaux-Pelzer, T, Thiele, F, Thomas, JP, Thomas-Wilsker, J, Thompson, PD, Thompson, AS, Thomsen, LA, Thomson, E, Tian, Y, Tibbetts, MJ, Torres, RET, Tikhomirov, VO, Tikhonov, YA, Timoshenko, S, Tipton, P, Tisserant, S, Todome, K, Todorova-Nova, S, Todt, S, Tojo, J, Tokar, S, Tokushuku, K, Tolley, E, Tomlinson, L, Tomoto, M, Tompkins, L, Toms, K, Tong, B, Tornambe, P, Torrence, E, Torres, H, Pastor, ET, Toth, J, Touchard, F, Tovey, DR, Treado, CJ, Trefzger, T, Tresoldi, F, Tricoli, A, Trigger, IM, Trincaz-Duvoid, S, Tripiana, MF, Trischuk, W, Trocme, B, Trofymov, A, Troncon, C, Trottier-McDonald, M, Trovaielli, M, Truong, L, Trzebinski, M, Trzupek, A, Tsang, KW, Tscang, JC-L, Tsiareshka, PV, Tsipolitis, G, Tsirintanis, N, Tsiskaridze, S, Tsiskaridze, V, Tskhadadze, EG, Tsukerman, IL, Tsulaia, V, Tsuno, S, Tsybychev, D, Tu, Y, Tudorache, A, Tudorache, B, Tulbure, TT, Tuna, AN, Turchikhin, S, Turgeman, D, Cakir, IT, Turra, R, Tuts, PM, Ucchielli, G, Ueda, I, Ughetto, M, Ukegawa, F, Unal, G, Undrus, A, Unel, G, Ungaro, FC, Unno, Y, Uno, K, Unverdorben, C, Urban, J, Urquijo, P, Urrejola, P, Usai, G, Usui, J, Vacavant, I, Vacek, V, Vachon, B, Vadla, KH, Vaidya, A, Valderanis, C, Santurio, EV, Valente, M, Valentinetti, S, Valero, A, Valery, I, Valkar, S, Vanier, A, Ferrer, JAV, Van Den Wollenberg, W, Van der Graaf, H, Van Gernmeren, P, Van Nieuwkoop, J, Van Vulpen, I, Van Woerden, MC, Vanadia, M, Vandelli, W, Vaniachine, A, Vankov, P, Vardanyan, G, Vari, R, Varnes, EW, Varni, C, Varol, T, Varouchas, D, Vartapetian, A, Varvell, KE, Vasquez, JG, Vasquez, GA, Vazeille, F, Furelos, DV, Schroeder, TV, Veatch, J, Veeraraghavan, V, Veloce, LM, Veloso, F, Veneziano, S, Ventura, A, Venturi, M, Venturi, N, Venturini, A, Vercesi, V, Verducci, M, Verkerke, W, Vermeulen, AT, Vermeulen, JC, Vetterli, MC, Maira, NV, Viazlo, O, Vichou, I, Vickey, T, Boeriu, EV, Viehhauser, GHA, Viel, S, Vigani, L, Villa, M, Perez, MV, Vilucchi, E, Vincter, MG, Vinogradov, VB, Vishwakarma, A, Vittori, C, Vivarelli, I, Vlachos, S, Vogel, M, Vokac, P, Volpi, G, Von der Schmitt, H, Von Toerne, 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Zhang, X, Zhang, Y, Zhang, Z, Zhao, X, Zhao, Y, Zhao, Z, Zhemchugov, A, Zhou, B, Zhou, C, Zhou, L, Zhou, M, Zhou, N, Zhou, Y, Zhu, CG, Zhu, H, Zhu, J, Zhu, Y, Zhuang, X, Zhukov, K, Zibell, A, Zieminska, D, Zimine, NI, Zimmermann, C, Zimmermann, S, Zinonos, Z, Zinser, M, Ziolkowski, M, Zivkovic, L, Zobernig, G, Zoccoli, A, Zou, R, Zur Nedden, M, and Zwalinski, L
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Science & Technology ,0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics ,MONTE-CARLO ,Physics ,High Energy Physics::Phenomenology ,Physical Sciences ,SIMULATION ,High Energy Physics::Experiment ,LHC ,Nuclear Experiment ,0206 Quantum Physics ,Nuclear & Particles Physics ,Physics, Particles & Fields - Abstract
This paper presents a measurement of the polarisation of τ leptons produced in Z/γ ∗ → τ τ decays which is performed with a dataset of proton—proton collisions at √s = 8 TeV, corresponding to an integrated luminosity of 20.2 fb−1 recorded with the ATLAS detector at the LHC in 2012. The Z/γ ∗ → τ τ decays are reconstructed from a hadronically decaying τ lepton with a single charged particle in the final state, accompanied by a τ lepton that decays leptonically. The τ polarisation is inferred from the relative fraction of energy carried by charged and neutral hadrons in the hadronic τ decays. The polarisation is measured in a fiducial region that corresponds to the kinematic region accessible to this analysis. The τ polarisation extracted over the full phase space within the Z/γ ∗ mass range of 66 < mZ/γ ∗ < 116 GeV is found to be Pτ = −0.14±0.02(stat)±0.04(syst). It is in agreement with the Standard Model prediction of Pτ = −0.1517 ± 0.0019, which is obtained from the ALPGEN event generator interfaced with the PYTHIA 6 parton shower modelling and the TAUOLA τ decay library.
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- 2018
15. Adalimumab Therapy Optimization in Refractory Uveitis Due to Behcet's Disease after Achieving Remission. interventional Versus Control Group
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Atienza-Mateo, B, Martin-Varillas, JL, Vegas-Revenga, N, Dominguez-Casas, LC, Calvo-Rio, V, Beltran, E, Sanchez-Burson, J, Mesquida, M, Adan, A, Hernandez, MV, Garfella, MH, Pascual, EV, Costa, LM, Sellas-Fernandez, A, Coma, MC, Diaz-Llopis, M, Gallego, R, Salom, D, Ortego, N, Garcia-Serrano, JL, Callejas-Rubio, JL, Herreras, JM, Garcia-Aparicio, AM, Maiz, O, Blanco, A, Torre, I, Valle, DD, Pato, E, Aurrecoechea, E, Caracuel, MA, Gamero, F, Minguez, E, Cubero, CC, Olive, A, Vazquez, J, Moreno, OR, Jimenez-Zorzo, F, Manero, J, Martinez, MG, Rubio-Romero, E, de Miera, FJTS, Lopez-Longo, J, Nolla, JM, Revenga, M, Demetrio, R, Pons, E, Gonzalez-Gay, MA, and Blanco, R
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- 2017
16. Hemophagocytic syndrome in patients from SLE Registry from the Spanish Society of Rheumatology (RELESSER)
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Lois Iglesias, Ana J., Rua Figueroa, I., De-Toro, Javier, Zea-Mendoza, A., López-Longo, J., Calvo, J., Galindo, M., Uriarte-Isacelaya, E., and Pego-Reigosa, J.
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Poster presentation Instituto de Salud Carlos III; PI11/02857
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- 2017
17. MINI IRENE: design of deployable heat shield capsule for a sounding rocket flight experiment
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Gardi, R., Fedele, A., Pezzella, G., Vernillo, P., Savino, Raffaele, Mungiguerra, S., Aversana, P. D., Gramiccia, L., Henriksson, K., Smith, J., and Longo, J.
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heat-shield ,re-entry ,deployable ,TPS - Published
- 2017
18. AB1441-HPR Does the incidence of infections increase in patients with chronic arthritis and osteoporosis treated with denosumab and biological therapy?
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Lopez Esteban, A, primary, Garcia, F., additional, Janta, I., additional, Ovalles, J.G., additional, Serrano, B., additional, Sanchez, J.C., additional, Garaballu, C., additional, Gonzalez, C., additional, Del Rio, T., additional, Lopez Longo, J., additional, Monteagudo, I., additional, and Nieto, J.C., additional
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- 2018
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19. AB0985 Persistence and adverse events in patients treated with denosumab
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Lopez, A., primary, Janta, I., additional, Nieto, J.C., additional, Martinez Barrio, J., additional, Serrano, B., additional, Garcia, F., additional, Sanchez, J.C., additional, Garaballu, C., additional, Del Rio, T., additional, Gonzalez, C., additional, Lopez Longo, J., additional, and Monteagudo, I., additional
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- 2018
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20. CMOS 3D-Extended Metal Gate ISFETs with Near Nernstian Ion Sensitivity
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Zhang, Jun-Rui, primary, Bellando, F., additional, Rupakula, M., additional, Cordero, E. Garcia, additional, Ebejer, N., additional, Longo, J., additional, Wildhaber, F., additional, Guerin, H., additional, and Ionescu, A.M., additional
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- 2018
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21. THU0282 The impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PSA) attending rheumatology clinics
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Fernández-Carballido, C., primary, Martín-Martínez, M., additional, García-Gómez, C., additional, Castañeda, S., additional, González-Juanatey, C., additional, Sánchez, F., additional, García-Vicuña, R., additional, Erausquin, C., additional, Lopez-Longo, J., additional, Sánchez-González, M., additional, Corrales, A., additional, Quesada, E., additional, Chamizo, E., additional, Barbadillo, C., additional, Bachiller, J., additional, Cobo, T., additional, Turrión, A., additional, Giner, E., additional, Llorca, J., additional, and González-Gay, M., additional
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- 2018
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22. Lab on skin™: 3D monolithically integrated zero-energy micro/nanofludics and FD SOI ion sensitive FETs for wearable multi-sensing sweat applications
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Bellando, F., primary, Garcia-Cordero, E., additional, Wildhaber, F., additional, Longo, J., additional, Guerin, H., additional, and Ionescu, A. M., additional
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- 2017
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23. SERS Investigation of Cancer Cells Treated with PDT: Quantification of Cell Survival and Follow-up
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Veloso, A. B., primary, Longo, J. P. F., additional, Muehlmann, L. A., additional, Tollstadius, B. F., additional, Souza, P. E. N., additional, Azevedo, R. B., additional, Morais, P. C., additional, and da Silva, S. W., additional
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- 2017
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24. AB1029 Ultrasound nail assessment in psoriatic arthritis and psoriasis compared with healthy controls
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Janta, I, primary, Rodriguez, O Baniandres, additional, Valor, L, additional, Barrio, J Martinez, additional, Ovalles, JG, additional, Gonzalez, JC Nieto, additional, Gonzalez, C, additional, Longo, J Lopez, additional, Monteagudo, I, additional, and Naredo, E, additional
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- 2017
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25. OP0042 Bacteremia in systemic lupus erythematosus patients from relesser registry: risk factors, clinical and microbiological characteristics and outcomes
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Rua-Figueroa, I, primary, Lόpez-Longo, J, additional, Galindo-Izquierdo, M, additional, Campo, V Del, additional, Cisneros, J De la Torre, additional, Uriarte, E, additional, Vela, P, additional, Tomero, E, additional, and Pego-Reigosa, J, additional
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- 2017
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26. THU0720-HPR Physical activity in patients with inflammatory arthropathies
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Esteban, A Lόpez, primary, Janta, I, additional, Gonzalez, JC Nieto, additional, García, F, additional, Garaballu, C, additional, Rio, T del, additional, Barbero, C, additional, Gonzalez, C, additional, Longo, J Lopez, additional, and Monteagudo, I, additional
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- 2017
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27. Maghemite–gold core–shell nanostructures (γ-Fe2O3@Au) surface-functionalized with aluminium phthalocyanine for multi-task imaging and therapy
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Coelho, B. C. P., primary, Siqueira, E. R., additional, Ombredane, A. S., additional, Joanitti, G. A., additional, Chaves, S. B., additional, da Silva, S. W., additional, Chaker, J. A., additional, Longo, J. P. F., additional, Azevedo, R. B., additional, Morais, P. C., additional, and Sousa, M. H., additional
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- 2017
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28. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
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Bonaca, MP, Bhatt, DL, Cohen, M, Steg, PG, Storey, RF, Jensen, EC, Magnani, G, Bansilal, S, Fish, MP, Im, K, Bengtsson, O, Ophuis, TO, Budaj, A, Theroux, P, Ruda, M, Hamm, C, Goto, S, Spinar, J, Nicolau, JC, Kiss, RG, Murphy, SA, Wiviott, SD, Held, P, Braunwald, E, Sabatine, MS, Morin, S, Dantzer, E, Acquilano, D, McGuire, RL, Gannon, JB, Gershman, E, Ahlbom, AM, Boberg, B, Abola, MT, Ardissino, D, Aylward, P, Corbalan, R, Dalby, A, Diaz, R, Hu, DY, Isaza, D, Kamensky, G, Kiss, R, Kontny, F, Lopez-Sendon, J, Medina, F, Montalescot, G, Nicolau, J, Paolasso, E, Parkhomenko, A, Van De Werf, F, Anderson, JL, White, HD, Verheugt, FWA, Pedersen, TR, DeMets, DL, Lowe, C, Arevalo, C, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Alvarisqueta, A, De Gennaro, N, Berli, M, Roude, AE, Di Gennaro, JA, Albisu, JF, Caccavo, A, Torres, M, Cuadrado, J, Bordoni, P, Cuello, J, Aviles, A, Glenny, 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Park, J, Choi, S, Park, K, Bae, Y, Lee, H, Kim, BK, Yoon, MH, Park, JS, Jang, H, Kim, C, Cho, EJ, Bae, J, Lee, D, Lee, J, Choi, YY, Dimulescu, D, Vintila, M, Fruntelata, A, Pirvu, O, Stanciulescu, G, Giuca, A, Militaru, C, Radoi, M, Bobescu, E, Crisu, D, Creteanu, M, Minescu, B, Bolohan, F, Manitiu, I, Bengus, C, Iosipescu, L, Ciobotaru, V, Basarab, G, Benedek, I, Constantinescu, M, Cristea, M, Capalneanu, R, Tatu-Chitoiu, G, Huidu, S, Protopopescu, L, Greavu, M, Diaconu, M, Blajan, D, Istratoaie, O, Lican, G, Bisoc, A, Doka, B, Jemna, D, Parasteac, M, Serban, L, Mihai, M, Cioca, G, Ochean, V, Costache, L, Andor, M, Stoica, D, Benedek, T, Sava, N, Anciu, M, Mot, S, Cornaciu, S, Boldueva, S, Golitsyn, S, Karpov, Y, Kobalava, Z, Konstantinov, V, Kuimov, A, Ezhov, M, Panov, A, Novikova, T, Simanenkov, V, Smolenskaya, O, Tsyba, L, Vishnevsky, A, Yakhontova, P, Kislyak, O, Demchenko, E, Yakovlev, A, Ermoshkina, L, Arkhipov, M, Galyavich, A, Strongin, L, Kosmacheva, E, Goloshchekin, B, Sidorenko, B, Izmozherova, N, Shustov, S, Orlikova, O, Lukyanov, Y, Koziolova, N, Nedogoda, S, Statsenko, M, Kotelnikov, M, Osipenko, M, Oshchepkova, E, Bolieva, L, Ryamzina, I, Pavlysh, E, Samokhvalova, M, Mironova, N, Buza, V, Shavarov, A, Serebrenitskaya, M, Khomyakova, L, Safarova, M, Lohovinina, N, Staroverov, I, Bitakova, F, Zakharova, N, Khurs, E, Belenky, D, Kositsyn, D, Rovnykh, Y, Kasatova, T, Lubinskaya, E, Omelchenko, M, Slukhaenko, I, Kozulin, A, Baleeva, L, Pochinka, I, Kizhvatova, N, Laptev, I, Bugrimova, M, Popov, A, Kovalevskaya, E, Orlikov, E, Paltsman, Z, Lamden, D, Surovtseva, M, Tsoma, V, Derevjanchenko, M, Streltsov, S, Bikbulatova, E, Dmitriev, V, Byazrova, S, Khovaeva, Y, Komandenko, O, Dlesk, A, Urban, M, Vinanska, D, Dzupina, A, Hranai, M, Cisar, P, Toth, P, Paulov, S, Sivak, V, Bolvanska, N, Pella, D, Palka, J, Nedelova, I, Benacka, J, Gergel, V, Hatalova, K, Kohut, P, Kovar, F, Knazeje, M, Macek, V, Sinska, R, Bugan, V, Badenhorst, JCW, Erasmus, L, Burgess, LJ, de Necker, I, Corbett, CH, Fouche, L, Dawood, SY, Conradie, C, Delport, EF, Kruger, M, Ebrahim, I, Bobak, C, Nethononda, MR, Nunkoo, T, van Rensburg, FPJ, Middle, R, Horak, AR, Henley, L, Mabin, TA, King, A, Ranjith, N, Ramdas, S, Roodt, A, Coetsee, E, Theron, H, Karsten, M, Van Zyl, LJ, Roscher, M, Venter, TP, de Kock, L, Becker, AC, Swanepoel, J, Ismail, SM, Dalby, AJ, Allman, J, Roux, JP, Christie, H, Naidoo, DP, Vawda, GHM, Manga, P, Olckers, W, Mpe, MT, Farrell, BM, Areses, ELD, Lopez, SV, Fernandez, JMC, Roldan, JG, Pavia, PG, Segovia, AG, Puig, JG, Garcia, VC, Aguilera, RM, Munoa, MD, Cortada, JB, Cereto, PC, Perez, IP, Cid, LP, Basilio, EG, Guerra, PC, Ortiz, AF, Balcones, LDV, Vera, TR, Martinez, JMG, Galvan, ED, Caballero, AH, Blanco, VMR, Lopez, JMR, Franco, MRP, Soriano, FR, Porcar, LC, Fillat, ARC, Moreno, SG, Montejano, MG, Guerrero, JMD, Coronado, JLB, Eizagaechevarria, NM, Araucua, GN, Rubio, AM, Roca, MC, Marimon, XGM, Perales, MV, Gonzalez, AB, Sastre, MP, Juanatey, JRG, Acuna, JMG, Al-Khalili, F, Lof, P, Bandh, S, Myllyla, L, Christensen, K, Johansson, K, Dellborg, M, Hultsberg-Olsson, G, Alstrom, P, Damm, TL, Erlinge, D, Brolin, G, Ravn-Fischer, PA, Johansson, P, Andreen, S, Linderfalk, C, Ram, B, Lindholm, CJ, Assarsson, E, Mooe, T, Lindberg, A, Paren, P, Moodh, J, Svensson, P, Andersson, I, Wodlin, P, Raschperger, A, Skogvard, P, Koch, A, Lind, N, Osberg, L, Nilsson, C, Svensson, K, Bengtsson, M, Samad, B, Nilsson, M, Berglund, E, Lundgren, C, Lindmark, K, Sundholm, C, Aladellie, L, Welin-Berger, B, Guneri, S, Dogan, NB, Ersanli, M, Coskun, U, Cayli, M, Seker, T, Camsari, A, Ozcan, T, Ongen, Z, Karadag, B, Boyaci, B, Sezenoz, B, Pekdemir, H, Hidayet, S, Erol, M, Yalcin, A, Sezer, M, Emet, S, Bozkurt, E, Ozen, MB, Lutay, Y, Dyadyk, O, Kholopov, L, Rudyk, I, Shaposhnikova, Y, Chopey, I, Ternuschak, T, Reshotko, D, Popova, G, Batushkin, V, Gema, A, Vizir, V, Berezyn, O, Lutai, M, Tovstukha, V, Shumakov, V, Pogurelska, O, Sirenko, Y, Rekovets, O, Kraiz, I, Kamenska, E, Tseluyko, V, Yakovleva, L, Yena, L, Artemenko, V, Koval, O, Kaplan, P, Karpenko, O, Nevolina, I, Bazilevych, A, Harbar, M, Rudenko, L, Beregova, O, Mostovyi, Y, Rasputina, L, Vatutin, M, Shevelok, A, Kovalenko, V, Polenova, N, Amosova, K, Tkachenko, L, Volkov, V, Zaprovalna, O, Storey, R, Thomas, M, Pell, A, Moriarty, A, Kinnin, M, Ahsan, A, Burton, J, ORourke, B, Young, J, Lang, C, Forbes, J, Rowlands, D, Hamill, S, Sprigings, D, Cadd, A, de Belder, M, Atkinson, B, Ramsey, M, Fagan, JC, Pye, M, Wright, L, Keeling, P, Hughes, D, Fraser, D, Phillips, H, Muthusamy, R, Lawan, M, Levy, T, Kennard, S, Bodalia, B, Mottram, J, Calvert, J, Brodie, K, Gunstone, A, Douglas, C, Trouton, T, Hunter, B, Gerber, R, Pepper, H, Mathur, A, Andiapen, M, Baumbach, A, Bowles, R, Hildick-Smith, D, McGregor, A, Loh, I, Plocky, J, Adams, K, Clemmer, K, Aggarwal, K, Burkhardt, V, Costa, M, Lemmertz, K, Anderson, J, York, T, Angiolillo, D, Green, E, Sperling, M, Vasquez, E, Aycock, G, Tatum, D, Amin, J, Davidson, A, Hendrix, E, Shepard, L, Strain, J, Michel, K, Talano, J, Szalanski, N, Berk, M, Ibarra, M, Bhagwat, R, Winterrowd, D, Bilazarian, S, Marsters, M, Blonder, R, Graf, L, Brilakis, E, Roesle, M, Byrd, L, Sullivan, A, Longo, J, Pennella, A, Westerhausen, D, Weil, R, Carr, K, Piazza, J, Carr, KW, Castello, R, Hawks, M, Chandna, H, Holly, D, Chandrashekhar, YS, Molinaro, N, Carter, M, Antonino, M, Kosmicki, D, Kelley, M, Richwine, R, Pazier, P, Glasgow, B, Bresee, S, Alexander, J, Concha, M, Martinez, E, Connelly, T, Schenks, R, Cooper, M, Garman, V, Condit, J, White, A, Fialkow, J, Mckercher, M, Luna, M, Soto, G, Prodafikas, J, Rambaud, B, Donovan, J, Mudd, D, Doty, W, Parsons, T, D'Urso, M, Bies, J, Han, J, Treadwell, M, Erickson, B, Dahl, P, Fattal, P, Braem, J, Felten, W, Prior, J, French, W, Barillas, O, Berger, R, Genova, E, Gelernt, M, Cockrell, D, Miller, G, Dumka, K, Gill, S, Elliot, S, Goldberg, R, Barrett, M, Gordon, P, Stern, L, Ayres, T, Rhule, V, Gupta, D, Holton, T, Haddad, T, Jain, J, Hakas, J, McSorley, J, Hamroff, G, Hollenweger, L, Wainwright, W, Jones, S, Casagrande, M, Casagrande, MG, Effat, M, Mardis, R, Henderson, D, Millard, D, Hermany, P, Meissner-Dengler, S, Hinchman, D, Luck, K, Hodson, R, Severson, L, Horwitz, P, Miller, K, Isserman, S, Moore, C, Jan, M, Bilyk, O, Kersh, R, DaCosta, A, Kim, E, Gonzales, C, Kmetzo, J, Taylor, D, Knutson, T, Belanger, B, Hage-Korban, E, Harrington, A, Murdock, D, Heiman, M, Dandekar, U, Khan, M, Khan, G, Lui, H, Holman, L, MacDonald, L, Derbyshire, S, Watkins, K, Mayer, N, Mitchell, B, McCullum, K, Delio-Cox, B, Mckay, R, Cloutier, J, McKenzie, M, Rodkey, K, McLaurin, B, Lack, A, Minisi, A, Jeter, D, Mitchell, R, Keane-Richmond, P, Stine, R, Bullivant, M, Morford, R, White, J, Oberoi, M, Geraldo-Abache, A, O'Dea, D, Mehta, R, Tang, N, Ong, S, Edwards, M, Osborne, J, Alonzo, C, Lev, V, Monroe, J, Popeil, L, Sorrentino, N, Portelli, J, Landi, T, Potu, R, Smith, N, Prashad, R, McDonough, C, Qureshi, M, Howe, A, Raikhel, M, Arsate, M, Rogers, W, Saag, L, Sangrigoli, R, Schwarz, L, Abu-Fadel, M, Hagee, A, Kinnaman, S, McDaniel, V, Wilson, V, Purcell, T, Roberts, J, Riofrio, K, Shah, U, Narang, S, Gredler, F, Knap, P, Shanes, J, Hansen, C, Sharma, M, Gibson, T, Sheldon, W, Bohn, A, Siegel, C, Tibbits, L, Singh, V, Nelson, M, Singh, N, Logwood, D, Randhawa, P, Vargas, B, Stegemoller, R, Cole, B, Aggarwal, R, Johnson, M, Steinhoff, J, Dunaway, B, Patel, K, Boomer, L, Taheri, H, Morgan, K, Tahirkheli, N, Santos, A, Thadani, U, Alexander, D, Bennett, W, Kelley, E, Thomas, J, Macnicholas, D, Varma, S, Evans, S, Vlastaris, A, Bittel, B, Voyce, S, Mack, B, Weiss, R, Fournier, T, Whitney, R, Orosco, C, Willis, J, VonGerichten, S, Wiseman, A, Sharrow, A, Wohns, D, Schuitema, J, Amin, M, Ramus, A, Wilson, W, Moeller, C, Newell, M, Tindell, L, Rivera, W, Kwierant, J, Bretton, E, Corbin, B, Labroo, A, Lopez, C, Brown, C, Craig, M, Lucca, M, Keinanen, T, Eisenberg, S, Fielding, M, Doorey, A, Squire, A, Suresh, D, Frost, J, Teklinski, A, Stone, B, Waksman, R, Griffin, S, Wharton, W, Blakely, J, Fishbein, G, Weller, C, Camp, A, Fisher, S, Meholick, A, Hejna, E, Anderson, R, Long, S, Parikh, S, Norton, N, Vijay, N, Washam, M, Smith, S, and Stepanov, N
- Abstract
BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.)
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- 2015
29. A cross sectional evaluation of an alcohol intervention targeting young university students
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Burns, Sharyn, Jancey, Jonine, Crawford, Gemma, Hallett, Jonathan, Portsmouth, Linda, Longo, J., Burns, Sharyn, Jancey, Jonine, Crawford, Gemma, Hallett, Jonathan, Portsmouth, Linda, and Longo, J.
- Abstract
BACKGROUND: Hazardous drinking has been found to be higher among young university students compared to their non-university peers. Although young university students are exposed to new and exciting experiences, including greater availability and emphasis on social functions involving alcohol there are few multi strategy comprehensive interventions aimed at reducing alcohol-related harms. METHODS: Random cross sectional online surveys were administered to 18-24 year old students studying at the main campus of a large metropolitan university in Perth, Western Australia. Prior to the completion of the second survey an alcohol intervention was implemented on campus. Completed surveys were received from 2465 (Baseline; T1) and 2422 (Post Year 1: T2) students. Students who consumed alcohol in the past 12 months were categorised as low risk or hazardous drinkers using the Alcohol Use Disorders Identification Test (AUDIT). Due to the cross sectional nature of the two samples two-tailed two-proportion z-test and two sample t-tests were employed to determine statistical significance between the two time periods for categorical and continuous variables respectively. RESULTS: At T1 and T2 89.1 % and 87.2 % of the total sample reported drinking alcohol in the past month respectively. Hazardous levels of alcohol consumption reduced slightly between T1 (39.7 %) and T2 (38 %). In both time periods hazardous drinkers reported significantly higher mean scores for experienced harm, second-hand harm and witnessed harm scores compared to low risk drinkers (p <0.001). Hazardous drinkers were significantly more likely to experience academic problems due to their alcohol consumption and to report more positive alcohol expectations than low risk drinkers at both time periods (p <0.001). CONCLUSIONS: Harms and problems for students who report hazardous drinking are of concern and efforts should be made to ensure integrated and targeted strategies reach higher risk students and focus on
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- 2016
30. AB0015 Evaluating The Effect of Anti-TNF, Anti-IL6R and Anti-CTLA4 on ACPA Isotypes in Patients with Rheumatoid Arthritis
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Hernandez-Flόrez, D., primary, del Río, T., additional, Nieto, J., additional, Ovalles, J., additional, Martínez, J., additional, Serrano, B., additional, Mata, C., additional, Gonzalez, C., additional, Monteagudo, I., additional, Lopez-Longo, J., additional, Naredo, E., additional, and Valor, L., additional
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- 2016
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31. Consequences of Low Risk and Hazardous Alcohol Consumption among University Students in Australia and Implications for Health Promotion Interventions
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Burns, Sharyn, Crawford, Gemma, Hallett, Jonathan, Jancey, Jonine, Portsmouth, Linda, Hunt, Kristen, Longo, J., Burns, Sharyn, Crawford, Gemma, Hallett, Jonathan, Jancey, Jonine, Portsmouth, Linda, Hunt, Kristen, and Longo, J.
- Abstract
Background: Hazardous alcohol consumption and associated harms are high among young university students. The university environment is conducive to excessive alcohol consumption with studies finding young university students to drink alcohol at higher levels than their non-university peers. Methods: A random sample of 18 - 24-year-old undergraduate, internal university students completed a survey (n = 2465) to investigate differences in self-reported personal, secondhand and witnessed alcohol-related harms, alcohol expectancies, pre-loading, and friends’ alcohol consumption between low risk and hazardous drinkers. Univariate and multivariate analyses are reported. Results: Almost 40% of students who had consumed alcohol in the past year reported drinking at hazardous levels. Univariate analyses found students who reported hazardous drinking reported significantly higher scores relating to experienced, second-hand, witnessed and academic problems compared to low risk drinkers. Hazardous drinkers were also more likely to pre-load, to drink at higher levels when pre-loading, have more friends who drank alcohol, have more friends who drank at hazardous levels and to score higher on alcohol expectancies. However both low risk and hazardous drinkers experienced a range of harms due to their own drinking including hangover (71.2%), unprotected sex (19.3%), regretted sex (16.8%) and drink-driving (17%).Looking after an intoxicated student (34.3%) and witnessing someone pass out (37.5%) were issues for all drinkers. Experienced alcohol related harms, academic problems, alcohol expectancies, close friends’ level of alcohol consumption, pre-loading in the last four weeks and level of consumption when pre-loading were predictors of hazardous drinking (p < 0.001). Conclusion: Young undergraduate university students are at risk of a range of academic, social, emotional and physical harms associated with their own and other students’ alcohol consumption. There is a need for integr
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- 2015
32. FRI0619-HPR Joint Prostheses and Biologic Therapies in a Rheumatologic Clinic
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Lόpez Esteban, A., primary, Montoro, M., additional, Nieto González, J.C., additional, Flor, C., additional, González, C.M., additional, Janta, I., additional, Martínez-Barrio, J., additional, Hinojosa, M., additional, Bello, N., additional, Mata-Martinez, C., additional, Serrano, B., additional, Lόpez-Longo, J., additional, Monteagudo, I., additional, Naredo, E., additional, and Carreño, L., additional
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- 2015
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33. FRI0424 Cardiovascular Events in Systemic Lupus Erythematosus (Sle): A Nationwide Study in Spain (Relesser Registry)
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Manrique-Arija, S., primary, Fernandez-Nebro, A., additional, Rua-Figueroa, Í., additional, Lopez-Longo, J., additional, Calvo-Alén, J., additional, Galindo, M., additional, and Pego-Reigosa, J.M., additional
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- 2015
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34. Maghemite–gold core–shell nanostructures (γ-Fe2O3@Au) surface-functionalized with aluminium phthalocyanine for multi-task imaging and therapy.
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Coelho, B. C. P., Siqueira, E. R., Ombredane, A. S., Joanitti, G. A., Chaves, S. B., da Silva, S. W., Chaker, J. A., Longo, J. P. F., Azevedo, R. B., Morais, P. C., and Sousa, M. H.
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- 2017
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35. Dietary Restriction Enhances CD8⁺ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity.
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Oswald BM, DeCamp LM, Longo J, Dahabieh MS, Bunda N, Ma S, Watson MJ, Sheldon RD, Vincent MP, Johnson BK, Ellis AE, Soper-Hopper MT, Isaguirre CN, Shen H, Williams KS, Crawford PA, Kaech S, Jang HJ, Krawczyk CM, and Jones RG
- Abstract
Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhancing CD8
+ T cell-mediated anti-tumor immunity. DR reshapes CD8+ T cell differentiation within the tumor microenvironment (TME), promoting the development of effector T cell subsets while limiting the accumulation of exhausted T (Tex) cells, and synergizes with anti-PD1 immunotherapy to restrict tumor growth. Mechanistically, DR enhances CD8+ T cell metabolic fitness through increased ketone body oxidation (ketolysis), which boosts mitochondrial membrane potential and fuels tricarboxylic acid (TCA) cycle-dependent pathways essential for T cell function. T cells deficient for ketolysis exhibit reduced mitochondrial function, increased exhaustion, and fail to control tumor growth under DR conditions. Our findings reveal a critical role for the immune system in mediating the anti-tumor effects of DR, highlighting nutritional modulation of CD8+ T cell fate in the TME as a critical determinant of anti-tumor immunity.- Published
- 2024
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36. An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells.
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Kaluba FC, Rogers TJ, Jeong YJ, Waldhart A, Sokol KH, Lee CJ, Daniels SR, Longo J, Johnson A, Sheldon RD, Jones RG, and Lien EC
- Abstract
Cancer cells are exposed to diverse metabolites in the tumor microenvironment that are used to support the synthesis of nucleotides, amino acids, and lipids needed for rapid cell proliferation
1-3 . Recent work has shown that ketone bodies such as β-hydroxybutyrate (β-OHB), which are elevated in circulation under fasting conditions or low glycemic diets, can serve as an alternative fuel that is metabolized in the mitochondria to provide acetyl-CoA for the tricarboxylic acid (TCA) cycle in some tumors4-7 . Here, we discover a non-canonical route for β-OHB metabolism, in which β-OHB can bypass the TCA cycle to generate cytosolic acetyl-CoA for de novo fatty acid synthesis in cancer cells. We show that β-OHB-derived acetoacetate in the mitochondria can be shunted into the cytosol, where acetoacetyl-CoA synthetase (AACS) and thiolase convert it into acetyl-CoA for fatty acid synthesis. This alternative metabolic routing of β-OHB allows it to avoid oxidation in the mitochondria and net contribute to anabolic biosynthetic processes. In cancer cells, β-OHB is used for fatty acid synthesis to support cell proliferation under lipid-limited conditions in vitro and contributes to tumor growth under lipid-limited conditions induced by a calorie-restricted diet in vivo . Together, these data demonstrate that β-OHB is preferentially used for fatty acid synthesis in cancer cells to support tumor growth., Competing Interests: Competing interests: R.G.J. is a scientific advisor to Servier Pharmaceuticals and is a member of the Scientific Advisory Board of Immunomet Therapeutics. All other authors declare no competing interests.- Published
- 2024
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37. Glucose-dependent glycosphingolipid biosynthesis fuels CD8 + T cell function and tumor control.
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Longo J, DeCamp LM, Oswald BM, Teis R, Reyes-Oliveras A, Dahabieh MS, Ellis AE, Vincent MP, Damico H, Gallik KL, Compton SE, Capan CD, Williams KS, Esquibel CR, Madaj ZB, Lee H, Roy DG, Krawczyk CM, Haab BB, Sheldon RD, and Jones RG
- Abstract
Glucose is essential for T cell proliferation and function, yet its specific metabolic roles in vivo remain poorly defined. Here, we identify glycosphingolipid (GSL) biosynthesis as a key pathway fueled by glucose that enables CD8
+ T cell expansion and cytotoxic function in vivo . Using13 C-based stable isotope tracing, we demonstrate that CD8+ effector T cells use glucose to synthesize uridine diphosphate-glucose (UDP-Glc), a precursor for glycogen, glycan, and GSL biosynthesis. Inhibiting GSL production by targeting the enzymes UGP2 or UGCG impairs CD8+ T cell expansion and cytolytic activity without affecting glucose-dependent energy production. Mechanistically, we show that glucose-dependent GSL biosynthesis is required for plasma membrane lipid raft integrity and aggregation following TCR stimulation. Moreover, UGCG-deficient CD8+ T cells display reduced granzyme expression and tumor control in vivo . Together, our data establish GSL biosynthesis as a critical metabolic fate of glucose-independent of energy production-required for CD8+ T cell responses in vivo ., Competing Interests: DECLARATION OF INTERESTS R.G.J. is a scientific advisor to Servier Pharmaceuticals and is a member of the Scientific Advisory Board of Immunomet Therapeutics.- Published
- 2024
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38. Global Workforce and Access: Demand, Education, Quality.
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Grover S, Court L, Amoo-Mitchual S, Longo J, Rodin D, Scott AA, Lievens Y, Yap ML, Abdel-Wahab M, Lee P, Harsdorf E, Khader J, Jia X, Dosanjh M, Elzawawy A, Ige T, Pomper M, Pistenmaa D, Hardenbergh P, Petereit DG, Sargent M, Cina K, Li B, Anacak Y, Mayo C, Prattipati S, Lasebikan N, Rendle K, O'Brien D, Wendling E, and Coleman CN
- Subjects
- Humans, Global Health, Developing Countries, Healthcare Disparities, Health Services Needs and Demand, Health Services Accessibility, Radiation Oncology, Neoplasms radiotherapy
- Abstract
There has long existed a substantial disparity in access to radiotherapy globally. This issue has only been exacerbated as the growing disparity of cancer incidence between high-income countries (HIC) and low and middle-income countries (LMICs) widens, with a pronounced increase in cancer cases in LMICs. Even within HICs, iniquities within local communities may lead to a lack of access to care. Due to these trends, it is imperative to find solutions to narrow global disparities. This requires the engagement of a diverse cohort of stakeholders, including working professionals, non-governmental organizations, nonprofits, professional societies, academic and training institutions, and industry. This review brings together a diverse group of experts to highlight critical areas that could help reduce the current global disparities in radiation oncology. Advancements in technology and treatment, such as artificial intelligence, brachytherapy, hypofractionation, and digital networks, in combination with implementation science and novel funding mechanisms, offer means for increasing access to care and education globally. Common themes across sections reveal how utilizing these new innovations and strengthening collaborative efforts among stakeholders can help improve access to care globally while setting the framework for the next generation of innovations., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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39. Sarcopenia is associated with survival in patients awaiting kidney transplant.
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Wendland J, Seth A, Ten Eyck P, Longo J, Binns G, Sanders ML, Hornickel JL, Swee M, Kalil R, and Katz DA
- Abstract
Background: The relationship of sarcopenia to frailty and other survival determinants in patients waitlisted for kidney transplant is not well characterized. Our goal was to evaluate the relationship of muscle area to functional and frailty metrics and its impact on survival in patients waitlisted for kidney transplant., Methods: Among 303 consecutively listed transplant candidates, 172 had a computed scan within 3 months of frailty and biochemical testing that permitted muscle area evaluation. Third lumbar level psoas muscle indices (total bilateral psoas area/height
2 ) were calculated. Testing included frailty metrics, treadmill and pedometer ability, troponin, and brain natriuretic peptide levels. Associations between muscle area, demographic, biochemical, and frailty measures were analyzed. Log-rank test was used to evaluate waitlist survival on the basis of muscle area, and multivariate Cox proportional hazards modeling was used to evaluate factors independently associated with survival., Results: Demographic factors associated with third lumbar level psoas muscle indices include male sex (P < .001), race (P = .02), age (P = .004), and body mass index (P < .0001). Grip strength, treadmill ability, and Sit-Stands positively correlated with third lumbar level psoas muscle indices (P < .01). Brain natriuretic peptide and Up and Go negatively correlated with third lumbar level psoas muscle indices (P < .01). Survival was significantly associated with third lumbar level psoas muscle indices (P = 0.02). Treadmill ability, Sit-Stands, Up and Go, race and muscle area were most closely associated with waitlist survival on multivariate modeling., Conclusion: Sarcopenia as assessed with muscle area measurements is independently associated with kidney waitlist survival. Functional ability and muscle area may be overlapping, but noncongruent, determinants of waitlist outcomes and may need to be individually assessed to create the most predictive survival model., Competing Interests: Conflict of Interest/Disclosure Dr Katz reports commercial research support for immunosuppression drug trials from Bristol Myers Squibb and participation in the Hansa Biopharma ConfideS imlifidase trial in highly sensitized transplant candidates. Dr Kalil reports a research grant from Eurofins. All other authors declare no potential conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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40. Statin Concentration in Prostatic Tissue is Subtype- and Dose-dependent.
- Author
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Chavarriaga J, Penn LZ, Khurram N, Lajkosz K, Longo J, Chen E, Fleshner N, van der Kwast T, and Hamilton RJ
- Abstract
Objective: To evaluate for the first time, comparative serum and prostate tissue concentrations of lipophilic and hydrophilic statins., Methods: After reviewing all patients who underwent radical prostatectomy between 1993 and 2019, we selected 80 patients taking atorvastatin (lipophilic) or rosuvastatin (hydrophilic) for cholesterol control and with available banked fresh-frozen tissue from the prostatectomy. Primary endpoint was serum and prostate statin concentration measured by HPLC-mass spectrometry analysis. Serum/prostate statin concentrations were compared between patients on atorvastatin and rosuvastatin, and patients receiving high- and low-dose statin, using the Mann-Whitney U test., Results: In total, 39 patients were taking atorvastatin and 41 were taking rosuvastatin. Thirty-eight and 42 were taking high- and low-dose statin, respectively. Statin concentration was measurable in the prostatic tissue of 15 patients (38.4%) taking atorvastatin (33.3% high-dose vs 42.8% low-dose) compared to 22 (53.6%) taking rosuvastatin (55% high-dose vs 52.3% low-dose). Median tissue concentration of rosuvastatin was greater than atorvastatin (3.98 ng/g vs 0.96 ng/g, P <.001). Dose-dependency was observed: median prostate concentration was higher in those taking high-dose versus low-dose statin for both atorvastatin (1.22 ng/g vs 0.79 ng/g, P = .69) and rosuvastatin (5.21 ng/g vs 1.99 ng/g, P <.001)., Conclusion: We have shown, for the first time, that lipophilic and hydrophilic statins can be measured in the prostate of patients with prostate cancer and that the concentrations are dependent on dose. Moreover, rosuvastatin, a hydrophilic statin, achieves a 4-fold higher concentration in the prostate., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
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41. NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion.
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Dahabieh MS, DeCamp LM, Oswald BM, Kitchen-Goosen SM, Fu Z, Vos M, Compton SE, Longo J, Williams KS, Ellis AE, Johnson A, Sodiya I, Vincent M, Lee H, Sheldon RD, Krawczyk CM, Yao C, Wu T, and Jones RG
- Abstract
The progressive decline of CD8 T cell effector function-also known as terminal exhaustion-is a major contributor to immune evasion in cancer. Yet, the molecular mechanisms that drive CD8 T cell dysfunction remain poorly understood. Here, we report that the Kelch-like ECH-associated protein 1 (KEAP1)-Nuclear factor erythroid 2-related factor 2 (NRF2) signaling axis, which mediates cellular adaptations to oxidative stress, directly regulates CD8 T cell exhaustion. Transcriptional profiling of dysfunctional CD8 T cells from chronic infection and cancer reveals enrichment of NRF2 activity in terminally exhausted (Tex
term ) CD8 T cells. Increasing NRF2 activity in CD8 T cells (via conditional deletion of KEAP1) promotes increased glutathione production and antioxidant defense yet accelerates the development of terminally exhausted (PD-1+ TIM-3+ ) CD8 T cells in response to chronic infection or tumor challenge. Mechanistically, we identify PTGIR, a receptor for the circulating eicosanoid prostacyclin, as an NRF2-regulated protein that promotes CD8 T cell dysfunction. Silencing PTGIR expression restores the anti-tumor function of KEAP1-deficient T cells. Moreover, lowering PTGIR expression in CD8 T cells both reduces terminal exhaustion and enhances T cell effector responses (i.e. IFN-γ and granzyme production) to chronic infection and cancer. Together, these results establish the KEAP1-NRF2 axis as a metabolic sensor linking oxidative stress to CD8 T cell dysfunction and identify the prostacyclin receptor PTGIR as an NRF2-regulated immune checkpoint that regulates CD8 T cell fate decisions between effector and exhausted states., Competing Interests: Competing interests: RGJ is a scientific advisor for Servier Pharmaceuticals and is a member of the Scientific Advisory Board of Immunomet Therapeutics.- Published
- 2024
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42. 13 C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.
- Author
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Ma EH, Dahabieh MS, DeCamp LM, Kaymak I, Kitchen-Goosen SM, Oswald BM, Longo J, Roy DG, Verway MJ, Johnson RM, Samborska B, Duimstra LR, Scullion CA, Steadman M, Vos M, Roddy TP, Krawczyk CM, Williams KS, Sheldon RD, and Jones RG
- Subjects
- Animals, Mice, Listeriosis metabolism, Listeriosis immunology, Listeriosis microbiology, Listeria monocytogenes, Citric Acid Cycle, Glucose metabolism, Mice, Inbred C57BL, Glutamine metabolism, CD8-Positive T-Lymphocytes metabolism, Acetates metabolism, Carbon Isotopes
- Abstract
Infusion of
13 C-labeled metabolites provides a gold standard for understanding the metabolic processes used by T cells during immune responses in vivo. Through infusion of13 C-labeled metabolites (glucose, glutamine, and acetate) in Listeria monocytogenes -infected mice, we demonstrate that CD8 T effector (Teff) cells use metabolites for specific pathways during specific phases of activation. Highly proliferative early Teff cells in vivo shunt glucose primarily toward nucleotide synthesis and leverage glutamine anaplerosis in the tricarboxylic acid (TCA) cycle to support adenosine triphosphate and de novo pyrimidine synthesis. In addition, early Teff cells rely on glutamic-oxaloacetic transaminase 1 (Got1)-which regulates de novo aspartate synthesis-for effector cell expansion in vivo. CD8 Teff cells change fuel preference over the course of infection, switching from glutamine- to acetate-dependent TCA cycle metabolism late in infection. This study provides insights into the dynamics of Teff metabolism, illuminating distinct pathways of fuel consumption associated with CD8 Teff cell function in vivo.- Published
- 2024
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43. Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models.
- Author
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Jenkins DP, Turner-Ivey B, Fromm Longo J, and Carroll SL
- Subjects
- Animals, Mice, Neoplasm Grading, Humans, Mice, Transgenic, Disease Models, Animal, Nerve Sheath Neoplasms genetics, Nerve Sheath Neoplasms pathology
- Abstract
Patients with the autosomal dominant tumor susceptibility syndrome neurofibromatosis type 1 (NF1) commonly develop plexiform neurofibromas (PNs) that subsequently transform into highly aggressive malignant peripheral nerve sheath tumors (MPNSTs). Understanding the process by which a PN transforms into an MPNST would be facilitated by the availability of genetically engineered mouse (GEM) models that accurately replicate the PN-MPNST progression seen in humans with NF1. Unfortunately, GEM models with Nf1 ablation do not fully recapitulate this process. This led us to develop P0-GGFβ3 mice, a GEM model in which overexpression of the Schwann cell mitogen neuregulin-1 (NRG1) in Schwann cells results in the development of PNs that progress to become MPNSTs with high frequency. However, to determine whether tumorigenesis and neoplastic progression in P0-GGFβ3 mice accurately model the processes seen in NF1 patients, we had to first prove that the pathology of P0-GGFβ3 peripheral nerve sheath tumors recapitulates the pathology of their human counterparts. Here, we describe the specialized methodologies used to accurately diagnose and grade peripheral nervous system neoplasms in GEM models, using P0-GGFβ3 and P0-GGFβ3;Trp53
+/- mice as an example. We describe the histologic, immunohistochemical, and histochemical methods used to diagnose PNs and MPNSTs, how to distinguish these neoplasms from other tumor types that mimic their pathology, and how to grade these neoplasms. We discuss the establishment of early-passage cultures from GEM MPNSTs, how to characterize these cultures using immunocytochemistry, and how to verify their tumorigenicity by establishing allografts. Collectively, these techniques characterize the pathology of PNs and MPNSTs that arise in GEM models and critically compare the pathology of these murine tumors to their human counterparts.- Published
- 2024
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44. Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice.
- Author
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Lyon GJ, Longo J, Garcia A, Inusa F, Marchi E, Shi D, Dörfel M, Arnesen T, Aldabe R, Lyons S, Nashat MA, and Bolton D
- Subjects
- Animals, Mice, Female, Male, Phenotype, Genetic Background, Maternal Inheritance genetics, Mice, Inbred C57BL, N-Terminal Acetyltransferase A genetics, N-Terminal Acetyltransferase A metabolism, N-Terminal Acetyltransferase E genetics, N-Terminal Acetyltransferase E metabolism, Mice, Knockout
- Abstract
Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene, NAA10, encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A (NatA) complex. There is extensive genetic variation in humans with missense, splice-site, and C-terminal frameshift variants in NAA10. In mice, Naa10 is not an essential gene, as there exists a paralogous gene, Naa12, that substantially rescues Naa10 knockout mice from embryonic lethality, whereas double knockouts (Naa10-/Y Naa12-/-) are embryonic lethal. However, the phenotypic variability in the mice is nonetheless quite extensive, including piebaldism, skeletal defects, small size, hydrocephaly, hydronephrosis, and neonatal lethality. Here we replicate these phenotypes with new genetic alleles in mice, but we demonstrate their modulation by genetic background and environmental effects. We cannot replicate a prior report of "maternal effect lethality" for heterozygous Naa10-/X female mice, but we do observe a small amount of embryonic lethality in the Naa10-/y male mice on the inbred genetic background in this different animal facility., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Lyon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
- Full Text
- View/download PDF
45. Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides.
- Author
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Schofield JH, Longo J, Sheldon RD, Albano E, Ellis AE, Hawk MA, Murphy S, Duong L, Rahmy S, Lu X, Jones RG, and Schafer ZT
- Subjects
- Humans, Animals, Cell Line, Tumor, Mice, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes metabolism, Peptides metabolism, Peptides pharmacology, Neoplasms immunology, Neoplasms pathology, Neoplasms metabolism, Neoplasms drug therapy, Cell Proliferation drug effects, Immune Evasion, Mice, Inbred C57BL, Carboxy-Lyases metabolism
- Abstract
Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppressive metabolites in the tumor microenvironment. Here, we find that αPD-1-resistant cancer cells produce abundant itaconate (ITA) due to enhanced levels of aconitate decarboxylase (Acod1). Acod1 has an important role in the resistance to αPD-1, as decreasing Acod1 levels in αPD-1-resistant cancer cells can sensitize tumors to αPD-1 therapy. Mechanistically, cancer cells with high Acod1 inhibit the proliferation of naive CD8
+ T cells through the secretion of inhibitory factors. Surprisingly, inhibition of CD8+ T cell proliferation is not dependent on the secretion of ITA but is instead a consequence of the release of small inhibitory peptides. Our study suggests that strategies to counter the activity of Acod1 in cancer cells may sensitize tumors to ICB therapy., Competing Interests: Declaration of interests R.G.J. is a scientific advisor for Agios Pharmaceuticals and Servier Pharmaceuticals and is a member of the scientific advisory board of ImmunoMet Therapeutics., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF
46. The Uncertainty in Family Caregivers of Hospitalized Persons With a Stroke in Saudi Arabia: Unitary Caring Perspective.
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Alselami S, Butcher HK, and Longo J
- Subjects
- Humans, Saudi Arabia, Uncertainty, Family, Qualitative Research, Caregivers, Stroke therapy
- Abstract
Uncertainty is a universal experience of family caregivers caring for persons with a stroke and affects caregivers' readiness to care for their family members with a stroke. Guided by the unitary caring theory and unitary-caring hermeneutic-phenomenological research method, this study was conducted among 15 family caregivers of persons in the hospital who have survived strokes through in-depth semi-structured interviews. Five essences emerged from the analysis: living in a dark reality; yearning for professional support; enduring a life full of tribulations; attempting resolution; and creating new patterns of living. Each of the 5 essences was interpreted from Smith's unitary caring theory perspective., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
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47. SLC3A2 N-glycosylation and Golgi remodeling regulate SLC7A amino acid exchangers and stress mitigation.
- Author
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Zhang C, Shafaq-Zadah M, Pawling J, Hesketh GG, Dransart E, Pacholczyk K, Longo J, Gingras AC, Penn LZ, Johannes L, and Dennis JW
- Subjects
- Humans, Adenosine Triphosphate metabolism, Amino Acids metabolism, Galectin 3 metabolism, Glycosylation, HeLa Cells, Polysaccharides metabolism, Fusion Regulatory Protein 1, Heavy Chain metabolism, Large Neutral Amino Acid-Transporter 1 metabolism, Stress, Physiological
- Abstract
Proteostasis requires oxidative metabolism (ATP) and mitigation of the associated damage by glutathione, in an increasingly dysfunctional relationship with aging. SLC3A2 (4F2hc, CD98) plays a role as a disulfide-linked adaptor to the SLC7A5 and SLC7A11 exchangers which import essential amino acids and cystine while exporting Gln and Glu, respectively. The positions of N-glycosylation sites on SLC3A2 have evolved with the emergence of primates, presumably in synchrony with metabolism. Herein, we report that each of the four sites in SLC3A2 has distinct profiles of Golgi-modified N-glycans. N-glycans at the primate-derived site N381 stabilized SLC3A2 in the galectin-3 lattice against coated-pit endocytosis, while N365, the site nearest the membrane promoted glycolipid-galectin-3 (GL-Lect)-driven endocytosis. Our results indicate that surface retention and endocytosis are precisely balanced by the number, position, and remodeling of N-glycans on SLC3A2. Furthermore, proteomics and functional assays revealed an N-glycan-dependent clustering of the SLC3A2∗SLC7A5 heterodimer with amino-acid/Na
+ symporters (SLC1A4, SLC1A5) that balances branched-chain amino acids and Gln levels, at the expense of ATP to maintain the Na+ /K+ gradient. In replete conditions, SLC3A2 interactions require Golgi-modified N-glycans at N365D and N381D, whereas reducing N-glycosylation in the endoplasmic reticulum by fluvastatin treatment promoted the recruitment of CD44 and transporters needed to mitigate stress. Thus, SLC3A2 N-glycosylation and Golgi remodeling of the N-glycans have distinct roles in amino acids import for growth, maintenance, and metabolic stresses., Competing Interests: Conflicts of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF
48. Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides.
- Author
-
Schofield JH, Longo J, Sheldon RD, Albano E, Hawk MA, Murphy S, Duong L, Rahmy S, Lu X, Jones RG, and Schafer ZT
- Abstract
Targeting PD-1 is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppressive metabolites in the tumor microenvironment (TME). Here, we find that αPD-1-resistant cancer cells produce abundant itaconate (ITA) due to enhanced levels of aconitate decarboxylase (Acod1). Acod1 has an important role in the resistance to αPD-1, as decreasing Acod1 levels in αPD-1 resistant cancer cells can sensitize tumors to αPD-1 therapy. Mechanistically, cancer cells with high Acod1 inhibit the proliferation of naïve CD8
+ T cells through the secretion of inhibitory factors. Surprisingly, inhibition of CD8+ T cell proliferation is not dependent on secretion of ITA, but is instead a consequence of the release of small inhibitory peptides. Our study suggests that strategies to counter the activity of Acod1 in cancer cells may sensitize tumors to ICB therapy.- Published
- 2023
- Full Text
- View/download PDF
49. Ketolysis drives CD8 + T cell effector function through effects on histone acetylation.
- Author
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Luda KM, Longo J, Kitchen-Goosen SM, Duimstra LR, Ma EH, Watson MJ, Oswald BM, Fu Z, Madaj Z, Kupai A, Dickson BM, DeCamp LM, Dahabieh MS, Compton SE, Teis R, Kaymak I, Lau KH, Kelly DP, Puchalska P, Williams KS, Krawczyk CM, Lévesque D, Boisvert FM, Sheldon RD, Rothbart SB, Crawford PA, and Jones RG
- Subjects
- 3-Hydroxybutyric Acid metabolism, 3-Hydroxybutyric Acid pharmacology, Acetylation, Ketone Bodies, Animals, Mice, CD8-Positive T-Lymphocytes, Histones metabolism
- Abstract
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8
+ T cell metabolism and effector function. βOHB directly increased CD8+ T effector (Teff) cell cytokine production and cytolytic activity, and KB oxidation (ketolysis) was required for Teff cell responses to bacterial infection and tumor challenge. CD8+ Teff cells preferentially used KBs over glucose to fuel the tricarboxylic acid (TCA) cycle in vitro and in vivo. KBs directly boosted the respiratory capacity and TCA cycle-dependent metabolic pathways that fuel CD8+ T cell function. Mechanistically, βOHB was a major substrate for acetyl-CoA production in CD8+ T cells and regulated effector responses through effects on histone acetylation. Together, our results identify cell-intrinsic ketolysis as a metabolic and epigenetic driver of optimal CD8+ T cell effector responses., Competing Interests: Declaration of interests R.G.J. is a scientific advisor for Agios Pharmaceuticals and Servier Pharmaceuticals and is a member of the Scientific Advisory Board of Immunomet Therapeutics., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF
50. Risk factors for multidrug-resistant tuberculosis in the Central African Republic: A case-control study.
- Author
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de Dieu Longo J, Woromogo SH, Tekpa G, Diemer HS, Gando H, Djidéré FA, and Grésenguet G
- Subjects
- Humans, Male, Adult, Female, Antitubercular Agents pharmacology, Antitubercular Agents therapeutic use, Case-Control Studies, Central African Republic epidemiology, Risk Factors, Tuberculosis, Multidrug-Resistant drug therapy, Tuberculosis, Multidrug-Resistant epidemiology, Mycobacterium tuberculosis
- Abstract
Background: The emergence and spread of multidrug-resistant tuberculosis (MDR-TB) presents a challenge to the "End TB by 2035" strategy. This study aimed to identify the risk factors associated with MDR-TB in patients admitted to the pneumo-physiology clinic of the National University Hospital of Bangui in Central African Republic., Methods: This was a "retrospective" chart review study. Cases were represented by patients more than 18 years of age treated for MDR-TB and controls were patients with "at least rifampicin-susceptible" TB treated "with first-line anti-TB regimen" and who at the end of treatment were declared cured. The status of "cured" was exclusively applicable to non-MDR TB. Risk factors associated with MDR-TB were identified by multivariate analysis., Results: We included 70 cases and 140 controls. The median age was 35 years, IQR (22;46 years). The main factors associated with the occurrence of MDR-TB in multivariate analysis were male gender (0 R = 3.02 [1.89-3.99], p = 0.001), residence in a peri-urban/urban area (0 R = 3.06 [2.21-4.01], p = 0.002), history of previous TB treatment (0 R= 3.99 [2.77-4.25], p < 0.001) and the presence of multidrug-resistant TB in the family (0 R=1.86 [1.27-2.45], p = 0.021)., Conclusion: The emergence of MDR-TB can be reduced by implementing appropriate strategies, such as preventive therapy in contacts of MDR-TB patients and detecting and appropriately treating MDR-TB patients to prevent further spread of infection., Competing Interests: Declaration of Competing Interest We have no conflict of interest to declare., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
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