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Your search keyword '"Luo, Xin-Hua"' showing total 13 results
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13 results on '"Luo, Xin-Hua"'

7. Homology analysis of 51 penicillin-intermediate Streptococcus pneumoniaeisolates from Wenzhou City, China

Author

Zhang, Jin, Hu, Da-Kang, Gao, Chun-Yan, Shen, Wei-Wei, Luo, Xin-Hua, Yu, Jian, Li, Xiang-Yang, Jiang, Xin-Yu, Zhu, Wu-Shuang, and Chen, Wei-Qing

Abstract

Objective To investigate drug resistance features and homology among penicillin-intermediate Streptococcus pneumoniaeisolates from Wenzhou City, China.Methods Fifty-one penicillin-intermediate S. pneumoniaeisolates were obtained from respiratory samples of infants and children hospitalized with lung infections. An antimicrobial susceptibility test was used to assess drug resistance. Polymerase chain reaction and agarose gel electrophoresis were used to identify S. pneumoniaeisolates and pulsed-field gel electrophoresis (PFGE) was used to analyze molecular subtypes. Hierarchical cluster analysis of PFGE fingerprints was used to compare genetic diversity and relatedness of S. pneumoniaeisolates. The Quellung test was used for serotyping.Results Fifty-one penicillin-intermediate S. pneumoniaeisolates showed evidence of multi-drug resistance and polyclonal origins. The isolates were classified into 25 subtypes through hierarchical cluster analysis of PFGE fingerprints. Three of these subtypes formed a supertype (15/51, 16/51 and 8/51 isolates), while the remaining subtypes occurred sporadically (12/51 isolates).Conclusions Transmission of penicillin-intermediate S. pneumoniaeis mostly vertical and to a lesser extent horizontal. Effective prevention strategies, including respiratory tract management and contact isolation, are essential to control nosocomial S. pneumoniaeinfection. Once susceptibility is confirmed, vancomycin, high-dose penicillin or third-generation cephalosporins (cefotaxime and ceftriaxone) may be used to treat penicillin-intermediate S. pneumoniae.

Published
2024
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9. Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

Author

Zhao, Xue-Ke, primary, Yu, Lei, additional, Cheng, Ming-Liang, additional, Che, Pulin, additional, Lu, Yin-Ying, additional, Zhang, Quan, additional, Mu, Mao, additional, Li, Hong, additional, Zhu, Li-Li, additional, Zhu, Juan-Juan, additional, Hu, Meng, additional, Li, Po, additional, Liang, Yue-Dong, additional, Luo, Xin-Hua, additional, Cheng, Yi-Ju, additional, Xu, Zhi-Xiang, additional, and Ding, Qiang, additional

Published
2017
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10. Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism

Author

Zhao, Xue-Ke, primary, Che, Pulin, additional, Cheng, Ming-Liang, additional, Zhang, Quan, additional, Mu, Mao, additional, Li, Hong, additional, Luo, Yuan, additional, Liang, Yue-Dong, additional, Luo, Xin-Hua, additional, Gao, Chang-Qing, additional, Jackson, Patricia L., additional, Wells, J. Michael, additional, Zhou, Yong, additional, Hu, Meng, additional, Cai, Guoqiang, additional, Thannickal, Victor J., additional, Steele, Chad, additional, Blalock, J. Edwin, additional, Han, Xiaosi, additional, Chen, Ching-Yi, additional, and Ding, Qiang, additional

Published
2016
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13. Expression of PERK-eIF2α-ATF4 pathway signaling protein in the progression of hepatic fibrosis in rats.

Author

Luo XH, Han B, Chen Q, Guo XT, Xie RJ, Yang T, and Yang Q

Abstract

Objective: This study aims to observe changes in the expression of the hepatic endoplasmic reticulum stress PERK-eIF2α-ATF4 signaling pathway protein in the progression of CCl 4 -induced hepatic fibrosis in rats., Methods: Male Wistar rats were sacrificed at the end of the 2 nd , 4 th , 8 th and 12 th weeks, respectively. A specific test was performed to compare the pathological changes of hepatic tissues in the model and normal groups. Immunohistochemical staining and Western blot were carried out to detect the expression of p-PERK, p-eIF2α and ATF4 proteins in the hepatic tissue group. Furthermore, real-time PCR was used to detect changes in the expression of ATF4 mRNA in hepatic tissues., Results: In the eight-week and twelve-week hepatic fibrosis group, significant fibrosis hyperplasia was identified in the livers of rats, and pseudo-lobules were also formed in the livers of rats in the twelve-week hepatic fibrosis group. Immunohistochemical staining and Western blot results indicated that the expression levels of p-PERK, p-eIF2α and the ATF4 protein in the livers of rats were significantly increased from the 8 th week compared with the normal group ( P <0.05). Real-time PCR results revealed that the expression of ATF4 mRNA was significantly increased in hepatic tissues in the hepatic fibrosis group compared with the normal group ( P <0.05), and this was gradually enhanced as hepatic fibrosis progressed., Conclusions: CCl 4 can induce an increase in the expression of the PERK-eIF2α-ATF4 signaling protein in the development of hepatic fibrosis along with phosphorylation-mediated activation, indicating that the activation of the PERK-eIF2α-ATF4 signaling pathway may contribute to the onset and development of hepatic fibrosis by regulating downstream target genes., Competing Interests: None., (IJCEP Copyright © 2018.)

Published
2018

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