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1. Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts

Author

Freak-Poli, Rosanne, Wagemaker, Nina, Wang, Rui, Lysen, Thom S, Ikram, M Arfan, Vernooij, Meike W, Dintica, Christina S, Vernooij-Dassen, Myrra, Melis, Rene JF, Laukka, Erika J, Fratiglioni, Laura, Xu, Weili, and Tiemeier, Henning

Subjects
Acquired Cognitive Impairment, Aging, Alzheimer's Disease, Brain Disorders, Prevention, Behavioral and Social Science, Neurodegenerative, Mental Health, Depression, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Clinical Research, Neurosciences, Mental health, Neurological, Good Health and Well Being, Aged, Aged, 80 and over, Cognitive Dysfunction, Female, Humans, Loneliness, Longitudinal Studies, Male, Mental Status and Dementia Tests, Middle Aged, Netherlands, Prevalence, Proportional Hazards Models, Risk Factors, Social Isolation, Sweden, cognition, dementia, depressive symptoms, interpersonal relations, loneliness, social support, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

BackgroundPoor social health is likely associated with cognitive decline and risk of dementia; however, studies show inconsistent results. Additionally, few studies separate social health components or control for mental health.ObjectiveTo investigate whether loneliness and social support are independently associated with cognitive decline and risk of dementia, and whether depressive symptoms confound the association.MethodsWe included 4,514 participants from the population-based Rotterdam Study (RS; aged 71±7SD years) followed up to 14 years (median 10.8, interquartile range 7.4-11.6), and 2,112 participants from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K; aged 72±10SD years) followed up to 10 years (mean 5.9±1.6SD). At baseline, participants were free of major depression and scored on the Mini-Mental State Examination (MMSE) ≥26 for RS and ≥25 for SNAC-K. We investigated loneliness, perceived social support, and structural social support (specifically marital status and number of children). In both cohorts, dementia was diagnosed and cognitive function was repeatedly assessed with MMSE and a global cognitive factor (g-factor).ResultsLoneliness was prospectively associated with a decline in the MMSE in both cohorts. Consistently, persons who were lonely had an increased risk of developing dementia (RS: HR 1.34, 95%CI 1.08-1.67; SNAC-K: HR 2.16, 95%CI 1.12-4.17). Adjustment for depressive symptoms and exclusion of the first 5 years of follow-up did not alter results. Neither perceived or structural social support was associated with cognitive decline or dementia risk.ConclusionLoneliness, not social support, predicted cognitive decline and incident dementia independently of depressive symptoms.

Published
2022

3. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

Author

Kocevska, Desana, Lysen, Thom S., Dotinga, Aafje, Koopman-Verhoeff, M. Elisabeth, Luijk, Maartje P. C. M., Antypa, Niki, Biermasz, Nienke R., Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J., Comijs, Hannie C., Corpeleijn, Eva, Dashti, Hassan S., de Bruin, Eduard J., de Graaf, Ron, Derks, Ivonne P. M., Dewald-Kaufmann, Julia F., Elders, Petra J. M., Gemke, Reinoldus J. B. J., Grievink, Linda, Hale, Lauren, Hartman, Catharina A., Heijnen, Cobi J., Huisman, Martijn, Huss, Anke, Ikram, M. Arfan, Jones, Samuel E., Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J., Groeniger, Joost Oude, Penninx, Brenda W. J. H., Picavet, H. Susan J., Pieters, Sara, Reijneveld, Sijmen A., Reitz, Ellen, Renders, Carry M., Rodenburg, Gerda, Rutters, Femke, Smith, Matt C., Singh, Amika S., Snijder, Marieke B., Stronks, Karien, ten Have, Margreet, Twisk, Jos W. R., Van de Mheen, Dike, van der Ende, Jan, van der Heijden, Kristiaan B., van der Velden, Peter G., van Lenthe, Frank J., van Litsenburg, Raphaële R. L., van Oostrom, Sandra H., van Schalkwijk, Frank J., Sheehan, Connor M., Verheij, Robert A., Verhulst, Frank C., Vermeulen, Marije C. M., Vermeulen, Roel C. H., Verschuren, W. M. Monique, Vrijkotte, Tanja G. M., Wijga, Alet H., Willemen, Agnes M., ter Wolbeek, Maike, Wood, Andrew R., Xerxa, Yllza, Bramer, Wichor M., Franco, Oscar H., Luik, Annemarie I., Van Someren, Eus J. W., and Tiemeier, Henning

Published
2021
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6. Sleep and perivascular spaces in the middle-aged and elderly population

Author

Lysen, Thom S., Yilmaz, Pinar, Dubost, Florian, Ikram, M. Arfan, de Bruijne, Marleen, Vernooij, Meike W., Luik, Annemarie I., Lysen, Thom S., Yilmaz, Pinar, Dubost, Florian, Ikram, M. Arfan, de Bruijne, Marleen, Vernooij, Meike W., and Luik, Annemarie I.

Abstract

Sleep has been hypothesised to facilitate waste clearance from the brain. We aimed to determine whether sleep is associated with perivascular spaces on brain magnetic resonance imaging (MRI), a potential marker of impaired brain waste clearance, in a population-based cohort of middle-aged and elderly people. In 559 participants (mean [SD] age 62 [6] years, 52% women) from the population-based Rotterdam Study, we measured total sleep time, sleep onset latency, wake after sleep onset and sleep efficiency with actigraphy and polysomnography. Perivascular space load was determined with brain MRI in four regions (centrum semiovale, basal ganglia, hippocampus, and midbrain) via a validated machine learning algorithm using T2-weighted MR images. Associations between sleep characteristics and perivascular space load were analysed with zero-inflated negative binomial regression models adjusted for various confounders. We found that higher actigraphy-estimated sleep efficiency was associated with a higher perivascular space load in the centrum semiovale (odds ratio 1.10, 95% confidence interval 1.04–1.16, p = 0.0008). No other actigraphic or polysomnographic sleep characteristics were associated with perivascular space load in other brain regions. We conclude that, contrary to our hypothesis, associations of sleep with perivascular space load in this middle-aged and elderly population remained limited to an association of a high actigraphy-estimated sleep efficiency with a higher perivascular space load in the centrum semiovale.

Published
2022

8. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Leerstoel Dekovic, Development and Treatment of Psychosocial Problems, Sub KGP, Urban Accessibility and Social Inclusion, LS IRAS EEPI ME (Milieu epidemiologie), Kocevska, Desana, Lysen, Thom S., Dotinga, Aafje, Koopman-verhoeff, M. Elisabeth, Luijk, Maartje P. C. M., Antypa, Niki, Biermasz, Nienke R., Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J., Comijs, Hannie C., Corpeleijn, Eva, Dashti, Hassan S., De Bruin, Eduard J., De Graaf, Ron, Derks, Ivonne P. M., Dewald-kaufmann, Julia F., Elders, Petra J. M., Gemke, Reinoldus J. B. J., Grievink, Linda, Hale, Lauren, Hartman, Catharina A., Heijnen, Cobi J., Huisman, Martijn, Huss, Anke, Ikram, M. Arfan, Jones, Samuel E., Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J., Groeniger, Joost Oude, Penninx, Brenda W. J. H., Picavet, H. Susan J., Pieters, Sara, Reijneveld, Sijmen A., Reitz, Ellen, Renders, Carry M., Rodenburg, Gerda, Rutters, Femke, Smith, Matt C., Singh, Amika S., Snijder, Marieke B., Stronks, Karien, Ten Have, Margreet, Twisk, Jos W. R., Van De Mheen, Dike, Van Der Ende, Jan, Van Der Heijden, Kristiaan B., Van Der Velden, Peter G., Van Lenthe, Frank J., Van Litsenburg, Raphaële R. L., Van Oostrom, Sandra H., Van Schalkwijk, Frank J., Sheehan, Connor M., Verheij, Robert A., Verhulst, Frank C., Vermeulen, Marije C. M., Vermeulen, Roel C. H., Verschuren, W. M. Monique, Vrijkotte, Tanja G. M., Wijga, Alet H., Willemen, Agnes M., Ter Wolbeek, Maike, Wood, Andrew R., Xerxa, Yllza, Bramer, Wichor M., Franco, Oscar H., Luik, Annemarie I., Van Someren, Eus J. W., Tiemeier, Henning, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Leerstoel Dekovic, Development and Treatment of Psychosocial Problems, Sub KGP, Urban Accessibility and Social Inclusion, LS IRAS EEPI ME (Milieu epidemiologie), Kocevska, Desana, Lysen, Thom S., Dotinga, Aafje, Koopman-verhoeff, M. Elisabeth, Luijk, Maartje P. C. M., Antypa, Niki, Biermasz, Nienke R., Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J., Comijs, Hannie C., Corpeleijn, Eva, Dashti, Hassan S., De Bruin, Eduard J., De Graaf, Ron, Derks, Ivonne P. M., Dewald-kaufmann, Julia F., Elders, Petra J. M., Gemke, Reinoldus J. B. J., Grievink, Linda, Hale, Lauren, Hartman, Catharina A., Heijnen, Cobi J., Huisman, Martijn, Huss, Anke, Ikram, M. Arfan, Jones, Samuel E., Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J., Groeniger, Joost Oude, Penninx, Brenda W. J. H., Picavet, H. Susan J., Pieters, Sara, Reijneveld, Sijmen A., Reitz, Ellen, Renders, Carry M., Rodenburg, Gerda, Rutters, Femke, Smith, Matt C., Singh, Amika S., Snijder, Marieke B., Stronks, Karien, Ten Have, Margreet, Twisk, Jos W. R., Van De Mheen, Dike, Van Der Ende, Jan, Van Der Heijden, Kristiaan B., Van Der Velden, Peter G., Van Lenthe, Frank J., Van Litsenburg, Raphaële R. L., Van Oostrom, Sandra H., Van Schalkwijk, Frank J., Sheehan, Connor M., Verheij, Robert A., Verhulst, Frank C., Vermeulen, Marije C. M., Vermeulen, Roel C. H., Verschuren, W. M. Monique, Vrijkotte, Tanja G. M., Wijga, Alet H., Willemen, Agnes M., Ter Wolbeek, Maike, Wood, Andrew R., Xerxa, Yllza, Bramer, Wichor M., Franco, Oscar H., Luik, Annemarie I., Van Someren, Eus J. W., and Tiemeier, Henning

Published
2021

9. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

Author

Planetary Health & Exposoom, Circulatory Health, Public Health Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cluster Onderzoek, Kocevska, Desana, Lysen, Thom S, Dotinga, Aafje, Koopman-Verhoeff, M Elisabeth, Luijk, Maartje P C M, Antypa, Niki, Biermasz, Nienke R, Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J, Comijs, Hannie C, Corpeleijn, Eva, Dashti, Hassan S, de Bruin, Eduard J, de Graaf, Ron, Derks, Ivonne P M, Dewald-Kaufmann, Julia F, Elders, Petra J M, Gemke, Reinoldus J B J, Grievink, Linda, Hale, Lauren, Hartman, Catharina A, Heijnen, Cobi J, Huisman, Martijn, Huss, Anke, Ikram, M Arfan, Jones, Samuel E, Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J, Groeniger, Joost Oude, Penninx, Brenda W J H, Picavet, H Susan J, Pieters, Sara, Reijneveld, Sijmen A, Reitz, Ellen, Renders, Carry M, Rodenburg, Gerda, Rutters, Femke, Smith, Matt C, Singh, Amika S, Snijder, Marieke B, Stronks, Karien, Ten Have, Margreet, Twisk, Jos W R, Van de Mheen, Dike, van der Ende, Jan, van der Heijden, Kristiaan B, van der Velden, Peter G, van Lenthe, Frank J, van Litsenburg, Raphaële R L, van Oostrom, Sandra H, van Schalkwijk, Frank J, Sheehan, Connor M, Verheij, Robert A, Verhulst, Frank C, Vermeulen, Marije C M, Vermeulen, Roel C H, Verschuren, W M Monique, Vrijkotte, Tanja G M, Wijga, Alet H, Willemen, Agnes M, Ter Wolbeek, Maike, Wood, Andrew R, Xerxa, Yllza, Bramer, Wichor M, Franco, Oscar H, Luik, Annemarie I, Van Someren, Eus J W, Tiemeier, Henning, Planetary Health & Exposoom, Circulatory Health, Public Health Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cluster Onderzoek, Kocevska, Desana, Lysen, Thom S, Dotinga, Aafje, Koopman-Verhoeff, M Elisabeth, Luijk, Maartje P C M, Antypa, Niki, Biermasz, Nienke R, Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J, Comijs, Hannie C, Corpeleijn, Eva, Dashti, Hassan S, de Bruin, Eduard J, de Graaf, Ron, Derks, Ivonne P M, Dewald-Kaufmann, Julia F, Elders, Petra J M, Gemke, Reinoldus J B J, Grievink, Linda, Hale, Lauren, Hartman, Catharina A, Heijnen, Cobi J, Huisman, Martijn, Huss, Anke, Ikram, M Arfan, Jones, Samuel E, Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J, Groeniger, Joost Oude, Penninx, Brenda W J H, Picavet, H Susan J, Pieters, Sara, Reijneveld, Sijmen A, Reitz, Ellen, Renders, Carry M, Rodenburg, Gerda, Rutters, Femke, Smith, Matt C, Singh, Amika S, Snijder, Marieke B, Stronks, Karien, Ten Have, Margreet, Twisk, Jos W R, Van de Mheen, Dike, van der Ende, Jan, van der Heijden, Kristiaan B, van der Velden, Peter G, van Lenthe, Frank J, van Litsenburg, Raphaële R L, van Oostrom, Sandra H, van Schalkwijk, Frank J, Sheehan, Connor M, Verheij, Robert A, Verhulst, Frank C, Vermeulen, Marije C M, Vermeulen, Roel C H, Verschuren, W M Monique, Vrijkotte, Tanja G M, Wijga, Alet H, Willemen, Agnes M, Ter Wolbeek, Maike, Wood, Andrew R, Xerxa, Yllza, Bramer, Wichor M, Franco, Oscar H, Luik, Annemarie I, Van Someren, Eus J W, and Tiemeier, Henning

Published
2021

10. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States:a systematic review and meta-analysis

Author

Kocevska, Desana, Lysen, Thom S, Dotinga, Aafje, Koopman-Verhoeff, M Elisabeth, Luijk, Maartje P C M, Antypa, Niki, Biermasz, Nienke R, Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J, Comijs, Hannie C, Corpeleijn, Eva, Dashti, Hassan S, de Bruin, Eduard J, de Graaf, Ron, Derks, Ivonne P M, Dewald-Kaufmann, Julia F, Elders, Petra J M, Gemke, Reinoldus J B J, Grievink, Linda, Hale, Lauren, Hartman, Catharina A, Heijnen, Cobi J, Huisman, Martijn, Huss, Anke, Ikram, M Arfan, Jones, Samuel E, Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J, Groeniger, Joost Oude, Penninx, Brenda W J H, Picavet, H Susan J, Pieters, Sara, Reijneveld, Sijmen A, Reitz, Ellen, Renders, Carry M, Rodenburg, Gerda, Rutters, Femke, Smith, Matt C, Singh, Amika S, Snijder, Marieke B, Stronks, Karien, Ten Have, Margreet, Twisk, Jos W R, Van de Mheen, Dike, van der Ende, Jan, van der Heijden, Kristiaan B, van der Velden, Peter G, van Lenthe, Frank J, van Litsenburg, Raphaële R L, van Oostrom, Sandra H, van Schalkwijk, Frank J, Sheehan, Connor M, Verheij, Robert A, Verhulst, Frank C, Vermeulen, Marije C M, Vermeulen, Roel C H, Verschuren, W M Monique, Vrijkotte, Tanja G M, Wijga, Alet H, Willemen, Agnes M, Ter Wolbeek, Maike, Wood, Andrew R, Xerxa, Yllza, Bramer, Wichor M, Franco, Oscar H, Luik, Annemarie I, Van Someren, Eus J W, Tiemeier, Henning, Kocevska, Desana, Lysen, Thom S, Dotinga, Aafje, Koopman-Verhoeff, M Elisabeth, Luijk, Maartje P C M, Antypa, Niki, Biermasz, Nienke R, Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J, Comijs, Hannie C, Corpeleijn, Eva, Dashti, Hassan S, de Bruin, Eduard J, de Graaf, Ron, Derks, Ivonne P M, Dewald-Kaufmann, Julia F, Elders, Petra J M, Gemke, Reinoldus J B J, Grievink, Linda, Hale, Lauren, Hartman, Catharina A, Heijnen, Cobi J, Huisman, Martijn, Huss, Anke, Ikram, M Arfan, Jones, Samuel E, Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J, Groeniger, Joost Oude, Penninx, Brenda W J H, Picavet, H Susan J, Pieters, Sara, Reijneveld, Sijmen A, Reitz, Ellen, Renders, Carry M, Rodenburg, Gerda, Rutters, Femke, Smith, Matt C, Singh, Amika S, Snijder, Marieke B, Stronks, Karien, Ten Have, Margreet, Twisk, Jos W R, Van de Mheen, Dike, van der Ende, Jan, van der Heijden, Kristiaan B, van der Velden, Peter G, van Lenthe, Frank J, van Litsenburg, Raphaële R L, van Oostrom, Sandra H, van Schalkwijk, Frank J, Sheehan, Connor M, Verheij, Robert A, Verhulst, Frank C, Vermeulen, Marije C M, Vermeulen, Roel C H, Verschuren, W M Monique, Vrijkotte, Tanja G M, Wijga, Alet H, Willemen, Agnes M, Ter Wolbeek, Maike, Wood, Andrew R, Xerxa, Yllza, Bramer, Wichor M, Franco, Oscar H, Luik, Annemarie I, Van Someren, Eus J W, and Tiemeier, Henning

Abstract

We aimed to obtain reliable reference charts for sleep duration, estimate the prevalence of sleep complaints across the lifespan and identify risk indicators of poor sleep. Studies were identified through systematic literature search in Embase, Medline and Web of Science (9 August 2019) and through personal contacts. Eligible studies had to be published between 2000 and 2017 with data on sleep assessed with questionnaires including ≥100 participants from the general population. We assembled individual participant data from 200,358 people (aged 1-100 years, 55% female) from 36 studies from the Netherlands, 471,759 people (40-69 years, 55.5% female) from the United Kingdom and 409,617 people (≥18 years, 55.8% female) from the United States. One in four people slept less than age-specific recommendations, but only 5.8% slept outside of the 'acceptable' sleep duration. Among teenagers, 51.5% reported total sleep times (TST) of less than the recommended 8-10 h and 18% report daytime sleepiness. In adults (≥18 years), poor sleep quality (13.3%) and insomnia symptoms (9.6-19.4%) were more prevalent than short sleep duration (6.5% with TST < 6 h). Insomnia symptoms were most frequent in people spending ≥9 h in bed, whereas poor sleep quality was more frequent in those spending <6 h in bed. TST was similar across countries, but insomnia symptoms were 1.5-2.9 times higher in the United States. Women (≥41 years) reported sleeping shorter times or slightly less efficiently than men, whereas with actigraphy they were estimated to sleep longer and more efficiently than man. This study provides age- and sex-specific population reference charts for sleep duration and efficiency which can help guide personalized advice on sleep length and preventive practices.

Published
2020

11. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

Author

Kocevska, Desana, primary, Lysen, Thom S., additional, Dotinga, Aafje, additional, Koopman-Verhoeff, M. Elisabeth, additional, Luijk, Maartje P. C. M., additional, Antypa, Niki, additional, Biermasz, Nienke R., additional, Blokstra, Anneke, additional, Brug, Johannes, additional, Burk, Wiliam J., additional, Comijs, Hannie C., additional, Corpeleijn, Eva, additional, Dashti, Hassan S., additional, de Bruin, Eduard J., additional, de Graaf, Ron, additional, Derks, Ivonne P. M., additional, Dewald-Kaufmann, Julia F., additional, Elders, Petra J. M., additional, Gemke, Reinoldus J. B. J., additional, Grievink, Linda, additional, Hale, Lauren, additional, Hartman, Catharina A., additional, Heijnen, Cobi J., additional, Huisman, Martijn, additional, Huss, Anke, additional, Ikram, M. Arfan, additional, Jones, Samuel E., additional, Velderman, Mariska Klein, additional, Koning, Maaike, additional, Meijer, Anne Marie, additional, Meijer, Kim, additional, Noordam, Raymond, additional, Oldehinkel, Albertine J., additional, Groeniger, Joost Oude, additional, Penninx, Brenda W. J. H., additional, Picavet, H. Susan J., additional, Pieters, Sara, additional, Reijneveld, Sijmen A., additional, Reitz, Ellen, additional, Renders, Carry M., additional, Rodenburg, Gerda, additional, Rutters, Femke, additional, Smith, Matt C., additional, Singh, Amika S., additional, Snijder, Marieke B., additional, Stronks, Karien, additional, ten Have, Margreet, additional, Twisk, Jos W. R., additional, Van de Mheen, Dike, additional, van der Ende, Jan, additional, van der Heijden, Kristiaan B., additional, van der Velden, Peter G., additional, van Lenthe, Frank J., additional, van Litsenburg, Raphaële R. L., additional, van Oostrom, Sandra H., additional, van Schalkwijk, Frank J., additional, Sheehan, Connor M., additional, Verheij, Robert A., additional, Verhulst, Frank C., additional, Vermeulen, Marije C. M., additional, Vermeulen, Roel C. H., additional, Verschuren, W. M. Monique, additional, Vrijkotte, Tanja G. M., additional, Wijga, Alet H., additional, Willemen, Agnes M., additional, ter Wolbeek, Maike, additional, Wood, Andrew R., additional, Xerxa, Yllza, additional, Bramer, Wichor M., additional, Franco, Oscar H., additional, Luik, Annemarie I., additional, Van Someren, Eus J. W., additional, and Tiemeier, Henning, additional

Published
2020
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19. Validity of the Maudsley Staging Method in Predicting Treatment-Resistant Depression Outcome Using the Netherlands Study of Depression and Anxiety

Author

van Belkum, Sjoerd M., van Belkum, Sjoerd M., Geugies, Hanneke, Lysen, Thom S., Cleare, Anthony J., Peeters, Frenk P. M. L., Penninx, Brenda W. J. H., Schoevers, Robert A., Ruhe, Henricus G., van Belkum, Sjoerd M., van Belkum, Sjoerd M., Geugies, Hanneke, Lysen, Thom S., Cleare, Anthony J., Peeters, Frenk P. M. L., Penninx, Brenda W. J. H., Schoevers, Robert A., and Ruhe, Henricus G.

Abstract

Objective: We investigated if the degree of treatment resistance of depression, as measured by the Maudsley Staging Method (MSM), is predictive of a worse depression outcome by using a large naturalistic cohort of depressed patients. Methods: 643 subjects from the general population, primary care, and secondary care who suffered from current depressive disorder were included from the Netherlands Study of Depression and Anxiety baseline assessment. The diagnostic criterion was major depressive disorder (MDD) in the last month, based on the Composite Interview Diagnostic Instrument (CIDI), or a CIDI diagnosis of MDD in the past 6 months with an Inventory of Depressive Symptomatology Self-Report score > 24 at baseline. In these subjects, composite scores of the MSM, based on duration, severity, and treatment history of current episode, were determined retrospectively. We then determined if the MSM score prospectively predicted the 2-year course of depression after baseline. The primary outcomes were percentage of follow-up time spent in a depressive episode and being "mostly depressed" (>= 50% of the follow-up) between baseline and 2-year follow-up. Results: The MSM predicted "percentage of follow-up time with depression" (P < .001) and was associated with being "mostly depressed" (OR = 1.40; 95% CI, 1.23-1.60; P < .001). These effects were not modified by having received treatment. Conclusions: The current study shows that the MSM is a promising tool to predict worse depression outcomes in depressed patients. In this study that adds to previous work, we show the applicability of MSM in a wider range of primary and secondary care patients with depression.

Published
2018

23. Subjective Sleep Quality is not Associated with Incident Dementia: The Rotterdam Study.

Author

Balouch, Sara, Lysen, Thom S., Ikram, M. Arfan, Wolters, Frank J., Ikram, M. Kamran, Luik, Annemarie I., and Tiemeier, Henning

Subjects
*SLEEP deprivation, *DEMENTIA risk factors, *COGNITION, *ALZHEIMER'S disease
Abstract

Background: Poor sleep is related to higher dementia risk, but this association is more equivocal for subjective sleep quality specifically. This study investigates the link between subjective sleep quality and dementia risk in the general population.Objective: To study the role of subjective sleep quality in the risk of dementia in the general population.Methods: In the prospective population-based Rotterdam Study, 4,835 persons (mean age 72 years, 58% women) underwent a home interview (2002- 2006) that included the validated Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality. Participants were followed until 2015 for incident dementia, through in-person screening and continuous monitoring of medical records. We used Cox regression models to associate sleep quality with dementia risk, adjusting for age, sex, education, smoking, employment, coffee consumption, alcohol consumption, activities of daily living, cardiovascular risk factors, anxiety, depressive symptoms, cognition, and snoring.Results: During 41,385 person-years (8.5 years mean), 420 participants developed dementia, of whom 320 Alzheimer's disease (AD). Poorer subjective sleep quality was not associated with the risk of all-cause dementia (hazard ratio [HR] per SD increase in PSQI score: 0.91, 95% CI 0.82- 1.02) or AD (HR 0.92, 95% CI 0.81- 1.05). Similarly, individual components of the PSQI were also not associated with dementia. Several sensitivity analyses, i.e., excluding last years of the follow-up time duration or restricting to those with best MMSE scores at baseline, did not reveal subgroups with increased risks.Conclusion: In this study, we found no association of poor subjective sleep quality with higher risk of dementia. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Sleep and perivascular spaces in the middle-aged and elderly population.

Author

Lysen TS, Yilmaz P, Dubost F, Ikram MA, de Bruijne M, Vernooij MW, and Luik AI

Subjects
Aged, Basal Ganglia, Brain diagnostic imaging, Brain pathology, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Sleep, Glymphatic System pathology
Abstract

Sleep has been hypothesised to facilitate waste clearance from the brain. We aimed to determine whether sleep is associated with perivascular spaces on brain magnetic resonance imaging (MRI), a potential marker of impaired brain waste clearance, in a population-based cohort of middle-aged and elderly people. In 559 participants (mean [SD] age 62 [6] years, 52% women) from the population-based Rotterdam Study, we measured total sleep time, sleep onset latency, wake after sleep onset and sleep efficiency with actigraphy and polysomnography. Perivascular space load was determined with brain MRI in four regions (centrum semiovale, basal ganglia, hippocampus, and midbrain) via a validated machine learning algorithm using T2-weighted MR images. Associations between sleep characteristics and perivascular space load were analysed with zero-inflated negative binomial regression models adjusted for various confounders. We found that higher actigraphy-estimated sleep efficiency was associated with a higher perivascular space load in the centrum semiovale (odds ratio 1.10, 95% confidence interval 1.04-1.16, p = 0.0008). No other actigraphic or polysomnographic sleep characteristics were associated with perivascular space load in other brain regions. We conclude that, contrary to our hypothesis, associations of sleep with perivascular space load in this middle-aged and elderly population remained limited to an association of a high actigraphy-estimated sleep efficiency with a higher perivascular space load in the centrum semiovale., (© 2021 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)

Published
2022
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