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The study investigates sea-level measurements along the coastal area of Europe for the 60-year (1961–2020) time span. Linear and quadratic modeling of tide gauge measurements showed an almost positive rate of trend of sea-level rise (0.09 to 3.6 mm/yr) and low acceleration (−0.05 to 0.40 mm/yr2). A least-squares harmonic estimation tidal modeling was carried out to estimate frequency (cycles per day) for a certain period. The smaller and higher tidal frequencies of these stations indicate their stability in terms of their surface variation. We used the 1993–2020 satellite altimetry data from the nearest grid points of the tide gauge station. The correlation coefficient between observed and satellite altimetry (lowest 0.53 and highest 0.93) varies at each station. This happens because of many factors that can affect the large difference in the sea-level trend between the satellite-derived and tide gauge results. Finally, to implement a global reference system for physical heights, the offshore topographic slope direction and slope range with contour spacing from the sea to the associated coastline were analyzed using bathymetry data. The abrupt change in slope from the coastline toward the sea can be seen toward the east, west, and southeast on the European coast. This is also an important factor that affects the variation of sea level.

Active tectonics in an area includes ongoing or recent geologic events. This paper investigates the tectonic influence on the subsidence, uplift and tilt of western Saurashtra through morphotectonic analysis of ten watersheds along with characteristics of relief and drainage orientation. Watersheds 7–9 to the north (N) are tectonically active, which can be linked with the North Kathiawar Fault System (NKFS) and followed by watersheds 6, 10, 1, 4 and 5. Stream-length gradient index and sinuosity index indicate the effect of tectonic events along the master streams in watersheds 6–9. Higher R2 values of the linear curve fit for watershed 7 indicate its master stream is much more tectonically active than the others. The R2 curve fitting model and earthquake magnitude/depth analysis confirm the region to be active. The reactivation of the NKFS most likely led to the vertical movement of western Saurashtra.

In the 21st Century, students' critical thinking abilities are needed to utilize their knowledge in problem-solving. Also, these skills are very important for students in making decisions when faced with various choices. This study aimed to see the effectiveness of students' critical thinking variables in the learning process. This study used a Research and Development (RND) method with an instrument in the form of a questionnaire consisting of 2 constructs. This study was carried out by involving seven teachers from several schools. Data collection was carried out by filling out an online questionnaire. Data were then analyzed with the help of the SPSS program. The results of this study prove that the preparation and development of the evaluation instrument of critical thinking variables in student worksheet media for students in this study were carried out by testing two research constructs, namely accuracy and effectiveness variables. Furthermore, the results of testing the validity and reliability indicate that the data validity of the evaluation instrument meets the valid criteria. Also, the results of this study indicate that the instrument developed meets the requirements for use in the development of student worksheet media.

In the 21st Century, students' critical thinking abilities are fundamental to facing challenges and increasing societal obstacles, especially students. This study aimed to determine the level of critical thinking abilities in SMP/MTs students. This study's significance is obtaining test results related to SMP/MTs students' critical thinking abilities. This study used a survey method involving 75 SMP/MTs students who were selected randomly. The instrument used a questionnaire containing critical thinking questions distributed online via Google Forms. The data obtained were analyzed using SPSS. Based on the survey results, it is known that the average student's critical thinking abilities are 8.0 with a good category which details can be explained as follows: 1) Providing simple explanations (8.0); 2) Building basic skills (7,9); 3) Drawing a conclusion from the data (7.5); 4) Providing further explanations (8.0); and 5) Developing a follow-up strategy (7.5). The results of this study allow a conclusion that the constructs with the highest average scores are providing simple explanations and providing further explanations with an average score of 8.0. Thus, it is recommended that students improve their critical thinking abilities and that teachers continue to use the instruments they have used.

The Indian western coast is petroliferous and draws attention from academicians and industrial experts. In this work, geomorphic indices have been calculated to decode neotectonics of the Konkan onshore region on India's west coast. Earthquake and Bouguer anomaly data have been used along with the present-day stress data from the World Stress Map project. Gravity modeling was performed in order to gain seismotectonic insights. The b-values were determined using Z-MAP 7.1 (2021). Morphometric analysis at both linear and spatial scales were performed using the digital elevation model from the data derived from the Shuttle Radar Topography Mission, analyzed with ArcGIS 10.3 (2014) software. Maps depicting slopes, aspects, and reliefs were created. NW-SE trending lineaments in the Konkan plain guided the major stream courses. Two of the five watersheds, watersheds 4 and 5, reveal high tectonic activity, are landslide-prone and host hot springs. Interestingly, watersheds 4 and 5 show high b-values (except near the rivers' sources), low Bouguer anomalies, and higher Hypsometric integral values (0.18523 and 0.16698) than the other watersheds. A low b-value in watershed 3 indicates stress accumulation. Over a larger area, the gravity trend varies from ∼ −80 to 30 mGal. The lineaments diagram deduced from the first vertical derivative technique shows that the structural fabrics mostly trend ∼ NW-SE at the west of the Western Ghat Escarpment (WGE) while it is NE-SW at the east. The tilt derivative ratio technique reveals a major NE-SW trend to the west of the WGE and an E-W trend to the east. Structural interpretations based on drill-cores around Koyna combined with geophysical studies for deep crust will be required are required for a better understanding of the blind (active) structures in the region.

Benoîte Mery,1,2,* Christine Ménétrier-Caux,2,3,* Laure Montané,4 Pierre-Etienne Heudel,1 Isabelle Ray-Coquard,1 Thomas Bachelot,1 Olfa Derbel,5 Paule Augereau,6 Isabelle Treilleux,2,7 Justine Berthet,2,3 Axelle Nkodia,3 Christine Bardin-Dit-Courageot,3 Valery Attignon,8 Anthony Ferrari,9 Gwenaele Garin,4 David Perol,4 Christophe Caux,2,3 Bertrand Dubois,2,3,* Olivier Trédan1,2,* 1Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 2Inserm U1052, CNRS 5286, Cancer Research Center of Lyon, Université Claude Bernard Lyon 1, Lyon, France; 3Laboratory of Cancer Immunotherapy of LYON (LICL), Centre Léon Bérard, Lyon, France; 4Clinical Research Platform (DRCI), Centre Léon Bérard, Lyon, France; 5Department of Medical Oncology, Hôpital Privé Jean-Mermoz, Lyon, France; 6Department of Medical Oncology, Institut de Cancérologie de L’ouest- Paul Papin, Angers, France; 7Biopathology Department, Centre Léon Bérard, Lyon, France; 8Genomic of Cancer Platform, Centre Léon Bérard, Lyon, France; 9Gilles Thomas Bioinformatics Platform, Synergie Lyon Cancer Foundation, Centre Léon Bérard, Lyon, France*These authors contributed equally to this workCorrespondence: Benoîte Mery, Department of Medical Oncology, Centre Léon Bérard, 28 Rue Laennec, Lyon, 69008, France, Tel +33 4 78 78 26 44, Fax +33 4 78 78 27 15, Email Benoite.mery@lyon.unicancer.frPurpose: Metastatic endocrine-resistant breast cancer (MBC) is a disease with poor prognosis and few treatment options. Low lymphocyte count is associated with limited overall survival. In a prospective cohort of lymphopenic patients with HER-2 negative MBC, we assessed the clinical and biological impact of pembrolizumab combined with metronomic cyclophosphamide.Experimental Design: This multicenter Phase II study evaluated the safety and clinical activity of pembrolizumab (intravenous (IV), 200mg, every 3 weeks) combined with metronomic cyclophosphamide (50mg/day, per os) in lymphopenic adult patients with HER2-negative MBC previously treated by at least one line of chemotherapy in this setting according to a Simon’s minimax two-stage design. Blood and tumor samples were collected to assess the impact of the combined treatment on circulating immune cells and the tumor immune microenvironment through multiparametric flow cytometry and multiplex immunofluorescence analyses. Primary endpoint was the clinical benefit rate at 6 months of treatment (CBR-6M). Secondary endpoints were objective response rate (ORR), duration of response, progression free survival (PFS), and overall survival (OS).Results: Two out of the twenty treated patients presented clinical benefit (one Tumor Mutational Burden (TMB)-high patient with complete response (CR) and one patient with objective response (OR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST V1.1) associated with a strong increase of cytokine-producing and proliferating CD4+ T cells and higher CD8+ T cells to macrophage ratios in the tumor. This impact on CD4+ and CD8+ T cell polyfunctionality was still observed more than one year for the patient with CR. A decreased in their absolute number of CD4+ and CD8+ memory T cells was observed in other patients.Conclusion: Pembrolizumab combined with metronomic cyclophosphamide was well tolerated, and displayed limited anti-tumoral activity in lymphopenic MBC. Correlative translational data of our trial advocates for additional studies with other chemotherapy combinations.Keywords: metastatic breast cancer, lymphopenia, immunotherapy, chemotherapy, immunomonitoring

The Kutch Rift Basin (KRB) is of great attention for its possible hydrocarbon reserve. In this context, geomorphologic and structural geologic studies of the onland basin area are crucial. Application of geomorphic indicators viz., compactness coefficient (Cc), lemniscate coefficient (k), form ratio (Rf), basin shape index (Bs), basin asymmetry factor (AF), hypsometric integral (HI), elongation ratio (Re) and circularity ratio (Rc) have been utilized to calculate the Index of Active Tectonics (IAT) for a part of KRB. Watersheds 5 (the Bhuj area), 9, 10, 11, 17, 18 and 20 belong to class 1 as per the IAT. This indicates that these watersheds are very highly tectonically active at present. Calculated valley floor width height ratio (Vf) and mountain front sinuosity (Smf) quantify the active valley incision in the Quaternary that uplifted the Bhuj area. This uplift was accompanied by a high-degree of drainage rejuvenation due to neotectonics and formation of a canyon in the Khari river. Paleostress analyses revealed NNE and NW-oriented extensions around Bhuj that can correspond to NW and NNE-trending normal fault planes, respectively.

Student Worksheets a media in the form of sheets containing tasks and activities that students must carry out, which are useful in supporting the learning process, one of which is in the material on the Structure and Function of Plant Tissues so that students can be active in the learning process. An assessment instrument is needed for the Student Worksheets. For this reason, this study aimed to measure the instrument's validity and reliability for using Student Worksheets as a learning media. This study used Research and Development (RND) methodology with an instrument in the form of a Student Worksheets measurement questionnaire consisting of three constructs: product design, material feasibility, and language feasibility. This research was carried out by involving seven teachers from several schools. Data were obtained by distributing the questionnaire via a Google form from September to October 2022 by obtaining prior consent from the respondents. The data obtained were quantitative, then analyzed using SPSS version 29 in the form of Alpha Cronbach analysis. The results of the test show that the validity of the instrument data meets the valid and reliable criteria with each Cronbach Alpha value per construct, namely Product Design (0.795), Material Feasibility (0.712), and Language Feasibility (0.712). Therefore, this study shows that the developed instrument meets the use requirements in developing Student Worksheets media students. Thus, stakeholders and teachers can use this instrument to develop media, particularly Student Worksheets, whereas further researchers can use this instrument to measure media before the study.

Perubahan kurikulum selalu terjadi menyesuaikan kebutuhan dan kondisi di lapangan. Mendikbud langsung meluncurkan program Merdeka belajar, hal ini disambut dengan kondisi dilapangan yang serba mengkhawatirkan karena adanya musibah yang melanda tidak hanya Indonesia tetapi juga dunia. Musibah tersebut yaitu berupa pandemic corona yang sangat mempengaruhi sendi-sendi kehidupan termasuk ekonomi, pendidikan. Tentu program ini sangat terkait dengan adanya penggunaan dan pemanfaat tekhnologi informasi dalam proses pembelajaran di sekolah. Untuk mendukung program merdeka belajar maka pengabdi ingin melakukan pelatihan dan bimbingan teknis pemanfaatan tekhnologi informasi dalam pembelajaran. Dalam pengabdian ini akan melibatkan para guru di Pelalawan. Pelatihan ini memberikan implikasi bagi guru SD untuk memanfaatkan TIK dalam pembelajaran daring.

Knowledge is an ability that students must possess in solving various problems and applying them in everyday life. This study aimed to determine how far the Effectiveness of knowledge variables for students in the learning process. This study uses the ADDIE development model. with the instrument in the form of a questionnaire consisting of 2 constructs. The survey study was carried out by involving ten teachers from various schools. Data collection techniques were carried out by filling out online questionnaires, which were then analyzed with the help of the SPSS program. The results of the research prove that: 1) the preparation and development of the evaluation of the problem variable instrument in the media for students in this study was carried out by testing two research constructs, namely 1) the accuracy of the variable and 2) the Effectiveness of the variable. As well as the results of testing the validity and reliability indicate that the data validity of the evaluation instrument meets the valid criteria. This research shows that the developed instrument meets the requirements for use in media development in the form of an e-module.

Abstract This study describes the initial ability of teachers in carrying out online learning activities. This research was conducted through survey research involving 154 elementary school teachers in Pelalawan and Rengat Regencies, Riau Provinces as the research samples were taken by purposive sampling. Research data were obtained through a survey using google forms and distributed via WhatsApp. Data analysis was carried out descriptively and inferentially using SPSS version 26. Based on the data analysis, it was identified that 97 teachers (63%) choose a combination learning model between offline and online as the most frequently learning model used during the covid-19 pandemic. In carrying out the learning process, 93 teachers (60.4%) chose schools as teaching locations. Regarding the quality of the internet in schools, 110 teachers (71.4%) assessed that the quality of the internet in schools was good and could support learning activities. Furthermore, teachers also apply various ways of teaching online learning, for example, 50 teachers (32.5%) choose to provide interactive material through online media and 45 teachers (29.2%) ask students to learn to use textbooks and give assignments to students in the form of assignments on worksheets, projects, books, etc. The main obstacle for teachers during online learning is that they find it difficult to observe student progress and have difficulty communicating with parents. The efforts made by teachers to adapt online learning is by providing materials/tasks and establishing basic competencies according to student needs.

This study aims to determine the strengthening of the 21st Century Skills of UPBJJ Pekanbaru and Pangkal Pinang students in dealing with the ASEAN economic community (MEA). The 21st Century Skills strengthening study was motivated by the low competition in economic politics in Indonesia. The study involved 379 students selected based on study programs at the Pekanbaru Open University and Pangkal Pinang. Data in the form of opinions and statements were collected using a questionnaire in the form of a questionnaire and essay. Data obtained were analyzed qualitatively and quantitatively. The results showed that UPBJJ Pekanbaru and Pangkal Pinang students were qualitatively ready to perform 21st-century skills, including digital era literacy, inventive thinking, memorable communication, high productivity, and spiritual norms and values. Based on quantitative data, there is no significant difference in strengthening the 21st Century Skills of UPBJJ Pekanbaru and Pangkal Pinang students.

Literacy skills are fundamental things that students must have in facing the industrial era 4.0 to be able to meet the needs of life in various situations. Scientific literacy is the ability to understand science, communicate science, and apply science skills to solve problems. However, the scores of Indonesian students on scientific literacy abilities are still far below the international standard scores set by the OECD institution. Seeing this phenomenon, this study aims to describe the profile of students' scientific literacy abilities. The research method used was a survey method. Informants who were used as research samples were 1210 Open University students. Data on students' scientific literacy abilities were collected through an online questionnaire using Google Form, then analyzed descriptively using the help of the SPSS program version 23.00 for Windows. The findings obtained in this study indicate the importance of scientific literacy skills that have a positive impact on knowledge, understanding and skills in using media, especially social media, which is currently often used as a source of information by audiences, especially students. Seeing the results of this study, the researcher recommended the need for universities or leaders so that students could improve students' scientific literacy skills. Keywords: ability, science literacy, natural science learning, covid-19 era, students. ABSTRAK Kemampuan literasi merupakan hal fundamental yang harus dimiliki oleh mahasiswa dalam menghadapi era industri 4.0 untuk dapat memenuhi kebutuhan hidup dalam berbagai situasi. Literasi sains merupakan kemampuan untuk memahami sains, mengkomunikasikan sains, serta menerapkan kemampuan sains untuk memecahkan masalah. Namun, skor siswa Indonesia pada kemampuan literasi sains masih jauh di bawah skor standar internasional yang ditetapkan oleh lembaga OECD. Melihat fenomena tersebut, penelitian ini bertujuan untuk mendeskripsikan profil kemampuan literasi sains mahasiswa. Metode penelitian digunakan adalah metode survey. Informan yang dijadikan sampel penelitian sebanyak 1210 orang mahasiswa Universitas Terbuka. Data kemampuan literasi sains mahasiswa dikumpulkan melalui kuisioner online menggunakan Google Form, kemudian dianalisis secara deskritif menggunakan bantuan Program SPSS versi 23.00 for Windows. Temuan yang diperoleh pada penelitian ini menunjukan pentingnya kemampuan literasi sains yang memberikan dampak positif bagi pengetahuan, pemahaman dan keterampilan dalam menggunakan media terutama media sosial yang saat ini sering dijadikan sumber informasi oleh khalayak terutama oleh kalangan mahasiswa. Melihat hasil penelitian tersebut, peneliti merekomendasikan perlunya universitas atau pimpinan agar mahasiswa dapat meningkatkan kemampuan literasi sains mahasiswa. Kata kunci: kemampuan, literasi sains, pembelajaran ipa, era covid-19, mahasiswa.

Research instruments are an important factor in a study in which the truth of researched results lies that determines the conclusion. Instruments are used to collect data and measure a research variable's object. This study aimed to retest a valid, consistent, and reliable instrument related to multiple intelligences previously developed by McClellan Conti. In this study, Multiple intelligences adapted from American psychologist, Howard Gardner, consisted of nine constructs, namely: (1) physical/kinesthetic, (2) existential/spiritual, (3) interpersonal, (4) intrapersonal, (5) logical thinking, (6) musical/rhythmic, (7) naturalistic, (8) verbal, and (9) visual. Designed as a survey study, it involved 140 respondents from primary education tutors of Universitas Terbuka at Pekanbaru selected using simple random sampling techniques. The data was analyzed using SPSS version 23.00 for Windows. The results showed that all questionnaire items were valid and reliable with a high average Cronbach Alpha reliability value (0.763 0.6), and every statement item has a high value (0.786 – 0.887) with a total construct value of 0.859. This study provides an alternative assessment related to multiple intelligence. Knowing each tutor's multiple intelligences will make the tutor focus more on the superiority of his intelligence. This will have good consequences for the development of the student learning process.

Andean lupin (Lupinus mutabilis) oil is rich in monounsaturated (54.2%) and polyunsaturated (28.5%) fatty acids but has a ω-3:ω-6 ratio (1:9.2) above the recommended values for human health. Sacha inchi (Plukenetia volubilis) oil presents a high polyunsaturated fatty acid content (linolenic 47.2% and linoleic 34.7%), along a ω-3:ω-6 ratio (1:0.74) good for human consumption. The objective of this research was to study the physico-chemical properties and oxidative stability of tarwi and sacha inchi oil blends (1:4, 1:3, 1:1, 3:1 and 4:1 w:w) with suitable ω-3:ω-6 ratios. All blends showed ω-3:ω-6 ratios between 1:0.8 and 1:1.9, acceptable from a nutritional point of view, and high total tocopherols’ content (1834–688 mg/kg), thanks to sacha inchi. The oxidative stability index (OSI) of the mixtures by the Rancimat method at 120 °C ranged from 0.46 to 8.80 h. The shelf-life of 1:1 tarwi/sacha inchi oil blend was 1.26 years; its entropy (−17.43 J/mol), enthalpy (107.04 kJ/mol), activation energy (110.24 kJ/mol) and Gibbs energy (113.76 kJ/mol) suggest low oxidation reaction rates and good stability. Hence, balanced blends of tarwi/sacha inchi oils can achieve optimal nutritional properties and enhanced shelf-life.

Background: Young maternal age is associated with negative outcomes at birth and with offspring's growth. In low- and middle-income countries, adolescents' offspring growth little has been studied.Objective: To determine the association of maternal sociodemographic characteristics with weight, length, and BMI change in adolescents' offspring in their first year of life.Methods: This is a one-year follow-up study that included adolescent mothers and their offspring from 2010 to 2017. The infant anthropometric variables were performed at birth, 3, 6, and 12 months. Maternal health, pregnancy, and social variables were evaluated as well as birth outcomes. Crude, percentage, Z score, and percentile changes of weight, length, and BMI were evaluated from birth to 1-year-old. Statistical analyses were adjusted by maternal chronological age, socioeconomic status, breastfeeding duration, the timing of introduction of complementary feeding, among other variables.Results: We examined 186 dyads (mother-infant). The median maternal age was 15.5 years, and the mean pre-pregnancy BMI was 20. The mean gestational age was 39.1 weeks for infants, birth weight was 3,039 g, and length at birth was 49.5-cm. Maternal chronological age, the timing of introduction of complementary feeding, socioeconomic status, and maternal occupation were associated with offspring's weight gain at 12 months. Length gain was associated with exclusive breastfeeding. Socioeconomic status and occupation were associated with offspring's BMI change. When performing adjusted multivariable analyses, weight and length at birth were associated weight and BMI at 12 months.Conclusions: Weight at birth may negatively predict infant's weight and BMI changes at 12 months, while length at birth may positively predict the changes. Maternal chronological age, socioeconomic level, occupation, and the timing of the introduction of complementary feeding were associated with the weight change. Only exclusive breastfeeding was associated with length Z-score change in adolescents' offspring in their first 12-months of life.

Financial inclusion is a condition of products or services from formal financial institutions that can be accessed and relished by various groups of society. Inclusive financial conditions can propel economic growths of the poor through formal financial institutions by forming business groups in each village. This article aims to address how the implementation of financial inclusion programs as a form of concrete efforts in the context of alleviating poverty in Rejang Lebong Regency. Moreover, this study uses a qualitative analysis method with a non-parametric qualitative approach. It shows that the presence of a financial inclusion programs in Rejang Lebong Regency can reduce the poverty level. This poverty alleviation effort is carried out through the pattern of providing venture capital to each Joint Business Group (KUBE) by raising regional superior products as its business, so as it can improve the economy of the local community. The distribution of venture capital assistance is also provided to Small and Medium-Sized Enterprises (UMKM) and religious organizations by maximizing the role and function of the Zakat Collecting Unit (UPZ) in each mosque for productive activities. Therefore, it is necessary to facilitate the granting of permits for the establishment of microfinance institutions such as Islamic cooperatives and savings and loan cooperatives as well as the synergy between the government, Islamic scholars, and the community in order to alleviate poverty through financial inclusion programs.

The investigation of river bed evolution is a principal part of fluvial morphology as it clarifies the procedure of bed deformation and morphological changes on alluvial river bed. Truth be told, the advancement of such bed landscape is additionally accompanied with the regular calamity like flood as it is anticipated due to immense precipitation in Himalayan foot slopes. The flood coverage area is expanding persistently while rainfall homogeneity is acceptable aside from extremely least number of years with sudden precipitation in most recent 101 years. The height of Jayanti riverbed had changed massively in most recent 101 years influencing the idea of channel planform accompanied by huge sediment aggradations and morphological changes which increases the expansion of flood water extension likelihood over bank. It has been discovered through the Fuzzy logic and PCA examination that precipitation does not assume a key job for flood water development yet dynamism of explicit river bed topography prompts bed rise that guarantees the flood propagation of the area unexpectedly.

Abstracts: The residents of the Eastern part of Indonesia, specifically, Papua and West Papua provinces, are dependent on traditional medicines with the use of plants, which includes treating malaria. However, there are limited information on the diversity of medicinal plants in Papua Island. Hence, the Indonesian Ministry of Health put together a database of all the natural plant-based raw materials in Indonesia, to address part of the issues encountered as a result of the limited information on the diversity of plants. Based on this background, the aim of the research was to analyze the information on medicinal plants used by the traditional healers in Papua Island based on the results of research on medicinal plants and Jamu (RISTOJA), especially in treating malaria. Data were obtained through ethnomedicine research conducted in 2012 and 2017 involving 54 ethnicities in Papua. Based on the results, 72 species of medicinal plants from 67 genera and 40 families were used traditionally in treating malaria on Papua Island. The most common medicinal plants used as traditional antimalarial concoction are Alstonia scholaris (L.) R. Br., Carica papaya L., Andrographis paniculata (Burm. f.) Nees, and Physalis minima L. Similar to other ethnobotany research, the leaves were the most used plant parts in preparing the various traditional concoctions.

The University of Riau holds a course known as "Bioetnomelayu." This course discusses the local wisdom of Malay culture in the bioenvironmental context This study was aimed to gain more extensive understanding concerning the implementation of bioethnomelayu in the classroom, assessed from the students' experience This is a qualitative research with in-depth interview method as a survey design The study shows that the bioethnomelayu course integrates biological sciences and indigenous entities, cultures and local wisdom in environmental management; thus, providing an outstanding experience in understanding local wisdom with the scientific basis for preserving the environment, even though about bioethnomelayu course has challenge like the literature regarding the local wisdom is limited. But it is very important to recognize the local wisdom of their ancestral heritage, to inherit the knowledge to the future generations. The implications for society can understand the local natural resources and how to develop them sustainably and environmentally friendly because Riau Province has diverse ecosystems and natural resources which are closely related to the nature in their daily life. This is represented in the local phrase of "nature as a teacher.

El aceite de sacha inchi es rico en ácidos grasos poli-insaturados que podrían oxidarse, limitando su vida útil. El método Rancimat, es oficial, para evaluaciones aceleradas de estabilidad oxidativa en aceites. A nivel industrial se usan técnicas convencionales basadas en indicadores fisicoquímicos, no existiendo estudios de correlación entre ellas y Rancimat. Este trabajo tiene por objetivo correlacionar el índice de estabilidad oxidativa (OSI) en aceite de sacha inchi obtenido mediante Rancimat a temperaturas de 80º, 90º, 100º y 110 ºC bajo un flujo de aire de 15 L/h, con los valores de indicadores fisicoquímicos tales como Índice de peróxido, p-anisidina, totox y densidad. Asimismo estimar mediante extrapolación matemática, la vida útil del aceite de sacha inchi a temperaturas usuales de almacenamiento. Se encontró valores OSI de: 0,493 ± 0,01 h a 110 ºC, 1,590 ± 0,06 h a 100 ºC, 4,645 ± 0,1 h a 90 ºC y 20,512 ± 0,02 h a 80 ºC. Se ha establecido alta correlación entre valores de OSI vs índices fisicoquímicos de calidad (0,9322 < r < 0,9965). La energía de activación encontrada fue de 137,90 kJ/mol, lo que explica la alta estabilidad oxidativa para el aceite, estimándose una vida útil de 3,29, 1,79 y 0,79 años a 20, 25 y 30 °C respectivamente.

Based on the concepts of Feature Fatigue, IT Fashion and IT Consumerization, this paper aims to investigate the relationships between them answering two questions: (1) does the phenomenon of IT Fashion result in Feature Fatigue? (2) Will the concept of Feature Fatigue cause the same effect when looking from the point of view of the IT Consumerization in the corporate environment? The research addresses these questions through two techniques: a laddering and a survey. Albeit tenuously, the results provide evidence that consumption motivated by IT Fashion leads to Feature Fatigue. This study contributes to management research by attempting at the phenomenon described from a multidisciplinary perspective, also contributing to management practice, specifically for marketing managers trying to understand the experiences and expectations of consumers, and also for IT managers engaged in the design of governance policies regarding the use of personal devices by employees in this context.

Background: Genome analysis could provide tools to assess predictive molecular biomarkers of radioresistance., Methods: Head and neck squamous cell carcinoma patients included in ProfiLER study and who underwent a curative radiotherapy were screened. Univariate and Cox multivariate analyses were performed to explore the relationships between molecular abnormalities, infield relapse and complete tumor response after radiation., Results: One hundred and forty-three patients were analyzed. PIK3CA mutation and genomic instability of MAP kinases pathway were found to be prognostic factors of loco-regional relapse in multivariate analysis with respectively HR 0.33, 95% CI 0.13-0.83, p = 0.005 and HR 0.61, 95% CI 0.38-0.96, p = 0.025. Instability of apoptosis pathway was found to be a prognostic factor of complete response after radiotherapy with HR 0.24, 95% CI 0.07-0.88, p = 0.04., Conclusion: This sub analysis suggests that PIK3CA mutation, variation of copy number of MAP kinases and apoptosis pathways play a significant role in the radioresistance phenomenon., (© 2021 Wiley Periodicals LLC.)

Introduction: There is very few data about the management of elderly patients with metastatic castration-resistant prostate cancer (mCRPC). The aim of this study was to analyze the management of patients aged 80 and over treated with docetaxel for a mCRPC., Methods and Materials: Clinical and pathological characteristics of octogerians treated with docetaxel were collected retrospectively from 3 French centers from 2009 to 2019. Patient's outcome, treatments administered before and/or after docetaxel were also analyzed., Results: Data of 89 patients could be analyzed. A total of 20.2 % of patients received the standard regimen and 79.8 % received an adapted one. Patients in the adapted group were significantly older than in standard one. Other patient's characteristics - including the geriatric scales - were similar. Dose reductions for toxicity were more frequent in the standard group (P=0.04). The median overall survival of the total population was 13.3 months. It was longer in the standard group than in the adapted group (26.1 months vs 12.4 months=0.01). In multivariate analysis, the type of docetaxel regimen (standard versus adapted) was an independent predictor of survival., Conclusion: This study suggests the benefit of the standard management even in oldest patients. A geriatric evaluation should certainly be processed in patients with poor oncogeriatric scale in order to select the sub-population able to receive the full dose standard docetaxel regimen., (Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Chordomas are rare malignant tumours, which typically occur in the axial skeleton and skull base. They arise from embryonic remnants of the notochord. They constitute less than 5 % of primary bone tumours. They are characterised by their locally aggressive potential with high frequency of recurrences and a median overall survival of 6 years. The initial therapeutic strategy must be discussed in an expert centre and may involve surgery, preoperative radiotherapy, exclusive radiotherapy or therapeutic abstention. Despite this, more than 50 % of patients will be facing recurrences with few therapeutic options available at this advanced stage. This review aims to outline current treatment options available in chordomas, as well as discussing potentiality of new therapeutic approaches through their molecular characterization and the comprehension of their immunological environment., (Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Human oncogenic papillomaviruses (HPV) have an increasingly prominent role in the genesis of many cancers. The oncogenic mechanisms associated with HPV are now better known and make it possible to explain the etiopathogenesis of the association. HPV status is now sought for certain cancers and conditions both prognosis and management of patients. Preventive antiviral vaccination has become a real public health issue and aims to effectively reduce the prevalence of cervical, anal and oropharynx cancer, HPV-associated. However, vaccination against HPV still lags behind. The purpose of this review is to redefine the involvement of HPV in several cancers as well as current therapeutic challenges of HPV-related cancers, notably in term of prevention., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)

Complementary and alternative medicines (CAMs) play more and more a significant role both in France and all over the world. Yet, their definition and their role in cancer treatments legitimately raise concerns. This article aims at establishing a picture of the CAMs admitted by the French Medical Board as well as those which are new or in common medical practices in France. We start with a brief reminder of their origin, their status and how they are used. Then, we review the literature about some of the best clinical trials using CAMs in cancer patients. To finish, we try to understand what makes CAMs so thrilling, but also why they create controversy and which common points they may have with conventional medicine., (Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Endocrine treatment represents the cornerstone of endocrine-sensitive pre-menopausal early breast cancer. The estrogen blockade plays a leading role in the therapeutic management with surgery, radiotherapy and selective antiestrogen treatment. For several years, selective estrogen receptor modulators, such as tamoxifen, have revolutionized medical care of hormone receptors-positive breast cancer and have conquered the therapeutic arsenal while becoming the gold standard of treatment. Other combinations associating the ovarian function suppression using LHRH agonists with tamoxifen or aromatase inhibitors have been recently investigated, leading to mitigated opinions regarding the clinical benefit of these associations. We propose here a comprehensive overview on existing data and their actualization concerning LHRH analogues, whilst emphasizing benefit-risk balance for this targeted population., (Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Head and neck cancer stem cells (CSCs) are highly resistant to treatment. When EGFR is overexpressed in head and neck squamous cell carcinoma (HNSCC), HER2 and HER3 are also expressed. The aim of the present study was to investigate the effect of HER1/2/3 blockade through a combination of cetuximab and pertuzumab, with or without photon irradiation, on the proliferation and migration/invasion capabilities of an HNSCC chemo- and radioresistant human cell line (SQ20B) and its corresponding stem cell subpopulation. Cell proliferation, migration and invasion were studied after treatment with cetuximab +/- pertuzumab +/- 10 Gy photon irradiation. EGFR, phospho-EGFR, HER2 and HER3 protein expression levels were studied. Activation or inhibition of the RAS/MAPK and AKT-mTOR downstream signalling cascades was investigated through phospho-AKT and phospho-MEK1/2 expression. Cetuximab strongly inhibited SQ20B and FaDu cell proliferation, migration and invasion, whereas it had little effect on SQ20B-CSCs. Cetuximab-pertuzumab combined with radiation significantly inhibited SQ20B and FaDu cell and SQ20B-CSC proliferation, migration and invasion. Cetuximab-pertuzumab with 10 Gy photon irradiation switched off both phospho-AKT and phospho-MEK1/2 expression in the three populations. The triple therapy is therefore thought to inhibit SQ20B cells, SQ20B-CSCs and FaDu cells through an AKT-mTOR and Ras-MAPK downstream signalling blockade.

The present review gives an overview of systematic reviews published in peer reviewed Journals analysing quality of reporting in oncology studies. PUBMED and Cochrane library were searched to identify systematic reviews assessing quality of reporting for randomized controlled trials (RCTs) and observational studies (OBS). Recommendations and primary endpoints used to assess the quality of reporting were described. Intrinsic quality of reporting was analyzed using an Overall Quality Score for literature Reviews (OQSR). Main evaluation themes were overall quality of reporting (20/58) and reporting of Health-Related Quality Of Life (HRQOL) in RCTs (7/58). Reporting recommendations used were not detailed in 56.9% of reviews. Insufficient reporting for the methodological description (randomization, blinding details, and allocation concealment) and the rationale for using specific measure of HRQOL were highlighted. OQSR was significantly higher for reviews published between 2010 and 2014 (after the PRISMA Publication), as compared to those published between 1996-2009 (median OQSR 10 (10-11) versus median OQSR 9 (6-10) respectively, p=0.0053). Intrinsic quality of reporting is satisfactory and has been improved in the last years., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Cell death plays a crucial role for a myriad of physiological processes, and several human diseases such as cancer are characterized by its deregulation. There are many methods available for both quantifying and qualifying the accurate process of cell death which occurs. Choosing the right assay tool is essential to generate meaningful data, provide sufficient information for clinical applications, and understand cell death processes. In vitro cell death assays are important steps in the search for new therapies against cancer as the ultimate goal remains the elaboration of drugs that interfere with specific cell death mechanisms. However, choosing a cell viability or cytotoxicity assay among the many available options is a daunting task. Indeed, cell death can be approached by several viewpoints and require a more holistic approach. This review provides an overview of cell death assays usually used in vitro for assessing cell death so as to elaborate new potential chemotherapeutics and discusses considerations for using each assay., Competing Interests: DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Disclosures and Ethics The authors have read and confirmed their agreement with the ICMJE. The authors have also confirmed that this article is unique and not under consideration or published in any other publication, and that they have permission from rights holders to reproduce any copyrighted material. The external blind peer reviewers report no conflicts of interest.

Head and neck cancer remains a significant public health concern. About 60% of patients die within 5years due to local recurrence. Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for new therapies against this disease. Furthermore, there is a need to test novel drugs before introduction into clinical practice. A preclinical model that closely resembles the in vivo situation would be highly valuable. In the last few decades, a multicellular spheroid model has gained attention as its behavior was comparable to in vivo tumors. Basic research is necessary to achieve an understanding of the normal and pathological state but cannot, in itself, provide sufficient information for clinical applications. Indeed, animal models are an inevitable prelude to assess the efficacy of new therapeutic approaches in HNSCC. The present review proposes an overview of HNSCC pre-clinical models in order to further understand the oncogenic properties for HNSCC and translate these findings into clinic for patients., (Copyright © 2016 Elsevier Ltd. All rights reserved.)