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299 results on '"Møller, Holger Jon"'

4. Unmeasurable low vitamin D levels caused by a novel, homozygote loss-of-function variant in the group-specific component gene.

Author

Nygaard, Rie Harboe, Lauritzen, Esben Stistrup, Sikjær, Tanja, Højskov, Carsten Schriver, Rejnmark, Lars, and Møller, Holger Jon

Subjects
VITAMIN D, NUCLEOTIDE sequencing, DIETARY supplements, WESTERN immunoblotting, CONSANGUINITY, HYPOKINESIA, OSTEOMALACIA
Abstract

A 29-year-old female, born to consanguineous parents, was found with unmeasurable levels of vitamin D (<10 nmol/L) after routine biochemical screening during her first pregnancy. She did not respond to either oral or intramuscular vitamin D supplementation and was an otherwise healthy young woman, with no signs of rickets, osteomalacia, osteoporosis, or secondary hyperparathyroidism. Western blot analysis revealed total lack of vitamin D binding protein, and next generation sequencing confirmed a novel, pathogenic homozygote loss-of-function mutation in exon 13 of the group-specific component gene , that encodes the poly A tail for vitamin D binding protein. She was therefore diagnosed with hereditary DBP deficiency, and vitamin D supplementation was diminished to life-long regular vitamin D supplementation (25 μg per day). This case is extremely interesting, as it expands our knowledge of vitamin D physiology and supports the free hormone hypothesis, given that the patient was asymptomatic despite no measurable levels of vitamin D. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Fungal translocation measured by serum 1,3‐ß‐D‐glucan correlates with severity and outcome of liver cirrhosis—A pilot study

Author

Egger, Matthias, primary, Horvath, Angela, additional, Prüller, Florian, additional, Fickert, Peter, additional, Finkelman, Malcolm, additional, Kriegl, Lisa, additional, Grønbæk, Henning, additional, Møller, Holger Jon, additional, Prattes, Juergen, additional, Krause, Robert, additional, Hoenigl, Martin, additional, and Stadlbauer, Vanessa, additional

Published
2023
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13. The association between soluble CD163, disease severity, and ursodiol treatment in patients with primary biliary cholangitis

Author

Bossen, Lars, primary, Lau, Tobias Stemann, additional, Nielsen, Mette Bak, additional, Nielsen, Marlene Christina, additional, Andersen, Astrid Højmark, additional, Ott, Peter, additional, Becker, Sabine, additional, Glerup, Henning, additional, Svenningsen, Lise, additional, Eivindson, Martin, additional, Kornerup, Linda, additional, Kjeldsen, Niels Bjørndal, additional, Neumann, Anders, additional, Møller, Holger Jon, additional, Jepsen, Peter, additional, and Grønbæk, Henning, additional

Published
2023
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14. Neoehrlichia mikurensis—An emerging opportunistic tick-borne infection in immunosuppressed patients

Author

Gynthersen, Rosa M.M., Stensvold, Christen Rune, Nielsen, Signe Ledou, Møller, Holger Jon, Nielsen, Henrik Vedel, Lebech, Anne Mette, Christensen, Jeppe Romme, Mens, Helene, El Fassi, Daniel, Gynthersen, Rosa M.M., Stensvold, Christen Rune, Nielsen, Signe Ledou, Møller, Holger Jon, Nielsen, Henrik Vedel, Lebech, Anne Mette, Christensen, Jeppe Romme, Mens, Helene, and El Fassi, Daniel

Abstract

Background Neoehrlichia mikurensis (N. mikurensis) is a newly discovered tick-borne pathogen that can inflict life-threatening illness in immunocompromised patients. N. mikurensis infection is only detectable by polymerase chain reaction (PCR)-based methodologies. We describe three distinct clinical manifestations of N. mikurensis infection (neoehrlichiosis) in Danish patients receiving B-lymphocyte-depleting therapy, rituximab, for underlying hematological, rheumatological, or neurological disorders. All three patients went through a protracted pre-diagnostic period. Methods N. mikurensis DNA was detected and confirmed using two methods. Blood was tested by specific real-time PCR targeting the groEL gene and by 16S and 18S profiling followed by sequencing. Bone marrow was analyzed by 16S and 18S profiling. Results N. mikurensis was detected in blood samples in all three cases and in bone marrow from one of the three. The severity of the symptoms ranged from prolonged fever lasting more than 6 months to life-threatening hyperinflammation in the form of hemophagocytic lymphohistiocytosis (HLH). Interestingly, all patients presented with splenomegaly and two with hepatomegaly. After starting doxycycline therapy, symptoms were relieved within a few days, and biochemistry and organomegaly quickly normalized. Conclusion We present three Danish patients recognized by the same clinician over a period of 6 months, strongly suggesting that many cases are going unrecognized. Second, we describe the first case of N. mikurensis-induced HLH and emphasize the potential severity of undetected neoehrlichiosis., Background: Neoehrlichia mikurensis (N. mikurensis) is a newly discovered tick-borne pathogen that can inflict life-threatening illness in immunocompromised patients. N. mikurensis infection is only detectable by polymerase chain reaction (PCR)-based methodologies. We describe three distinct clinical manifestations of N. mikurensis infection (neoehrlichiosis) in Danish patients receiving B-lymphocyte-depleting therapy, rituximab, for underlying hematological, rheumatological, or neurological disorders. All three patients went through a protracted pre-diagnostic period. Methods: N. mikurensis DNA was detected and confirmed using two methods. Blood was tested by specific real-time PCR targeting the groEL gene and by 16S and 18S profiling followed by sequencing. Bone marrow was analyzed by 16S and 18S profiling. Results: N. mikurensis was detected in blood samples in all three cases and in bone marrow from one of the three. The severity of the symptoms ranged from prolonged fever lasting more than 6 months to life-threatening hyperinflammation in the form of hemophagocytic lymphohistiocytosis (HLH). Interestingly, all patients presented with splenomegaly and two with hepatomegaly. After starting doxycycline therapy, symptoms were relieved within a few days, and biochemistry and organomegaly quickly normalized. Conclusion: We present three Danish patients recognized by the same clinician over a period of 6 months, strongly suggesting that many cases are going unrecognized. Second, we describe the first case of N. mikurensis-induced HLH and emphasize the potential severity of undetected neoehrlichiosis.

Published
2023

25. Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Author

Indira Chandran, Vineesh, primary, Wernberg, Charlotte Wilhelmina, additional, Lauridsen, Mette Munk, additional, Skytthe, Maria Kløjgaard, additional, Bendixen, Sofie Marchsteiner, additional, Larsen, Frederik Tibert, additional, Hansen, Camilla Dalby, additional, Grønkjær, Lea Ladegaard, additional, Siersbæk, Majken Storm, additional, Caterino, Tina Di, additional, Detlefsen, Sönke, additional, Møller, Holger Jon, additional, Grøntved, Lars, additional, Ravnskjaer, Kim, additional, Moestrup, Søren Kragh, additional, Thiele, Maja Sofie, additional, Krag, Aleksander, additional, and Graversen, Jonas Heilskov, additional

Published
2022
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27. Macrophage activation marker sCD163 is associated with liver injury and hepatic insulin resistance in obese patients before and after Roux-en-Y gastric bypass

Author

Kazankov, Konstantin, Bojsen-Møller, Kirstine Nyvold, Møller, Holger Jon, Madsbad, Sten, Grønbæk, Henning, Kazankov, Konstantin, Bojsen-Møller, Kirstine Nyvold, Møller, Holger Jon, Madsbad, Sten, and Grønbæk, Henning

Abstract

Background: Macrophages are associated with metabolic complications to obesity including fatty liver disease and impaired hepatic and muscle insulin sensitivity (IS). Bariatric surgery induces weight loss and improves IS. We investigated associations between the macrophage activation marker soluble (s)CD163, alanine-aminotransferase (ALT), and IS before and after Roux-en-Y Gastric Bypass (RYGB). Methods: We analyzed sCD163 from 10 type 2 diabetes (T2D) and 10 obese patients with normal glucose tolerance (NGT) undergoing RYGB for associations with hepatic, adipose tissue, and muscle IS and ALT after 1-week, 3, and 12 months postoperatively. IS was evaluated by hyperinsulinemic-euglycemic clamp in combination with glucose tracer technique. Results: Preoperative sCD163 correlated with ALT (r = 0.58, p = 0.007) and tended to associate inversely with hepatic (r = −0.39, p = 0.1) and adipose tissue (r = −0.39, p = 0.09), but not muscle IS. Following RYGB, sCD163 decreased significantly in all patients. The decrease in sCD163 during the first 3 months correlated inversely with the improvement of hepatic IS (r = −0.65, p = 0.01) and tended to be associated with changes in muscle IS (r = −0.45, p = 0.09). After 3 months sCD163 remained associated with ALT (r = 0.75, p < 0.001) and inversely with hepatic IS (r = −0.39, p = 0.1), but not muscle or adipose tissue IS. One year after RYGB, sCD163 correlated with ALT (r = 0.61, p = 0.007), but not with hepatic, adipose tissue, or muscle IS. Conclusion: Macrophage activation is associated with liver injury and hepatic IS in obese patients. Improvements in these measures correlate during the first 3 months following RYGB, supporting a link between macrophages and hepatic IS in severe obesity and diabetes.

Published
2022

31. Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness.

Author

Indira Chandran, Vineesh, Wernberg, Charlotte Wilhelmina, Lauridsen, Mette Munk, Skytthe, Maria Kløjgaard, Bendixen, Sofie Marchsteiner, Larsen, Frederik Tibert, Hansen, Camilla Dalby, Grønkjær, Lea Ladegaard, Siersbæk, Majken Storm, Caterino, Tina Di, Detlefsen, Sönke, Møller, Holger Jon, Grøntved, Lars, Ravnskjaer, Kim, Moestrup, Søren Kragh, Thiele, Maja Sofie, Krag, Aleksander, and Graversen, Jonas Heilskov

Published
2023
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32. Patients with Primary Central Nervous System Lymphoma Have High Levels of Soluble Programmed Cell Death Protein 1 in Their Pretherapeutic Cerebrospinal Fluid

Author

Severinsen, Rasmus Svane Ditlev, primary, Enemark, Marie Beck, additional, Mortensen, Julie Bondgaard, additional, Kjeldsen, Eigil, additional, Thorsgaard, Michael, additional, Pulczynski, Elisa Jacobsen, additional, Oettingen, Gorm von, additional, Møller, Holger Jon, additional, Vejgaard, Christopher, additional, Bjerre, Mette, additional, and d'Amore, Francesco, additional

Published
2021
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33. Divergences in Macrophage Activation Markers Soluble CD163 and Mannose Receptor in Patients With Non-cirrhotic and Cirrhotic Portal Hypertension

Author

Ørntoft, Nikolaj Worm, primary, Blé, Michel, additional, Baiges, Anna, additional, Ferrusquia, Jose, additional, Hernández-Gea, Virginia, additional, Turon, Fanny, additional, Magaz, Marta, additional, Møller, Søren, additional, Møller, Holger Jon, additional, Garcia-Pagan, Juan Carlos, additional, and Gronbaek, Henning, additional

Published
2021
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34. Additional file 1 of The macrophage activation marker soluble CD163 is elevated and associated with liver disease phenotype in patients with Wilson’s disease

Author

Glavind, Emilie, Gotthardt, Daniel N., Pfeiffenberger, Jan, Sandahl, Thomas Damgaard, Bashlekova, Teodora, Willemoe, Gro Linno, Hasselby, Jane Preuss, Weiss, Karl Heinz, Møller, Holger Jon, Vilstrup, Hendrik, Lee, William M., Schilsky, Michael L., Ott, Peter, and Grønbæk, Henning

Abstract

Additional file 1: Supplementary Figure 1. Histology illustrating scoring algorithm. Control liver tissue with low, moderate and high density of CD163 positive cells. (A) low density = score 1; (B) moderate density = score 2; and (C) high density = score 3. Supplementary Table 1. Characteristics for chronic Wilson's disease patients treated with current medical treatment for less than or equal to 12 months or more than 12 months. Supplementary Table 2. Multiple logistic regression model with soluble CD163, alanine aminotransferase, bilirubin, albumin, international normalized ratio, creatinine, age and gender as the explanatory variables for cirrhosis in patients with chronic Wilson’s disease.

Published
2020
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35. Macrophage activation markers, CD163 and CD206, in acute-on-chronic liver failure

Author

Nielsen, Marlene Christina, Hvidbjerg Gantzel, Rasmus, Clària, Joan, Trebicka, Jonel, Møller, Holger Jon, Grønbæk, Henning, Nielsen, Marlene Christina, Hvidbjerg Gantzel, Rasmus, Clària, Joan, Trebicka, Jonel, Møller, Holger Jon, and Grønbæk, Henning

Abstract

Macrophages facilitate essential homeostatic functions e.g., endocytosis, phagocytosis, and signaling during inflammation, and express a variety of scavenger receptors including CD163 and CD206, which are upregulated in response to inflammation. In healthy individuals, soluble forms of CD163 and CD206 are constitutively shed from macrophages, however, during inflammation pathogen- and damage-associated stimuli induce this shedding. Activation of resident liver macrophages viz. Kupffer cells is part of the inflammatory cascade occurring in acute and chronic liver diseases. We here review the existing literature on sCD163 and sCD206 function and shedding, and potential as biomarkers in acute and chronic liver diseases with a particular focus on Acute-on-Chronic Liver Failure (ACLF). In multiple studies sCD163 and sCD206 are elevated in relation to liver disease severity and established as reliable predictors of morbidity and mortality. However, differences in expression- and shedding-stimuli for CD163 and CD206 may explain dissimilarities in prognostic utility in patients with acute decompensation of cirrhosis and ACLF.

Published
2020

38. Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease

Author

Nissen, Sara Konstantin, primary, Ferreira, Sara Almeida, additional, Nielsen, Marlene Christina, additional, Schulte, Claudia, additional, Shrivastava, Kalpana, additional, Hennig, Dorle, additional, Etzerodt, Anders, additional, Graversen, Jonas Heilskov, additional, Berg, Daniela, additional, Maetzler, Walter, additional, Panhelainen, Anne, additional, Møller, Holger Jon, additional, Brockmann, Kathrin, additional, and Romero‐Ramos, Marina, additional

Published
2020
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40. First trimester biomarkers for prediction of gestational diabetes mellitus

Author

Tenenbaum-Gavish, Kinneret, primary, Sharabi-Nov, Adi, additional, Binyamin, Dana, additional, Møller, Holger Jon, additional, Danon, David, additional, Rothman, Lihi, additional, Hadar, Eran, additional, Idelson, Ana, additional, Vogel, Ida, additional, Koren, Omry, additional, Nicolaides, Kypros H., additional, Gronbaek, Henning, additional, and Meiri, Hamutal, additional

Published
2020
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41. Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence Survey Among 17 971 Healthcare and Administrative Personnel at Hospitals, Prehospital Services, and Specialist Practitioners in the Central Denmark Region

Author

Jespersen, Sanne, primary, Mikkelsen, Susan, additional, Greve, Thomas, additional, Kaspersen, Kathrine Agergård, additional, Tolstrup, Martin, additional, Boldsen, Jens Kjærgaard, additional, Redder, Jacob Dvinge, additional, Nielsen, Kent, additional, Abildgaard, Anders Mønsted, additional, Kolstad, Henrik Albert, additional, Østergaard, Lars, additional, Thomsen, Marianne Kragh, additional, Møller, Holger Jon, additional, and Erikstrup, Christian, additional

Published
2020
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42. SARS-CoV-2 seroprevalence survey among 18,000 healthcare and administrative personnel at hospitals, pre-hospital services, and specialist practitioners in the Central Denmark Region

Author

Jespersen, Sanne, primary, Mikkelsen, Susan, additional, Greve, Thomas, additional, Kaspersen, Kathrine Agergård, additional, Tolstrup, Martin, additional, Boldsen, Jens Kjærgaard, additional, Redder, Jacob Dvinge, additional, Nielsen, Kent, additional, Abildgaard, Anders Mønsted, additional, Kolstad, Henrik Albert, additional, Østergaard, Lars, additional, Thomsen, Marianne Kragh, additional, Møller, Holger Jon, additional, and Erikstrup, Christian, additional

Published
2020
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46. Improved prediction of mortality by combinations of inflammatory markers and standard clinical scores in patients with acute‐on‐chronic liver failure and acute decompensation

Author

Grønbæk, Henning, primary, Møller, Holger Jon, additional, Saliba, Faouzi, additional, Zeuzem, Stefan, additional, Albillos, Agustin, additional, Ariza, Xavier, additional, Graupera, Isabel, additional, Solà, Elsa, additional, Amoros, Alex, additional, Pavesi, Marco, additional, Bossen, Lars, additional, Jalan, Rajiv, additional, Gines, Pere, additional, and Arroyo, Vicente, additional

Published
2020
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47. Fibrogenesis and inflammation contribute to the pathogenesis of cirrhotic cardiomyopathy

Author

Wiese, Signe, primary, Voiosu, Andrei, additional, Hove, Jens D., additional, Danielsen, Karen V., additional, Voiosu, Theodor, additional, Grønbaek, Henning, additional, Møller, Holger Jon, additional, Genovese, Federica, additional, Reese-Petersen, Alexander Lynge, additional, Mookerjee, Rajeshwar P., additional, Clemmesen, Jens Otto, additional, Gøtze, Jens Peter, additional, Andersen, Ove, additional, Møller, Søren, additional, and Bendtsen, Flemming, additional

Published
2020
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50. Effect of Intravenous 25OHD Supplementation on Bone Turnover and Inflammation in Prolonged Critically Ill Patients

Author

Ingels, Catherine, additional, Vanhorebeek, Ilse, additional, Van Cromphaut, Sophie, additional, Wouters, Pieter J., additional, Derese, Inge, additional, Dehouwer, Alexander, additional, Møller, Holger Jon, additional, Hansen, Troels K., additional, Billen, Jaak, additional, Mathieu, Chantal, additional, Bouillon, Roger, additional, and Van den Berghe, Greet, additional

Published
2020
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