1. Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition
- Author
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Taira Monge, Elena Agnello, Maurizio Fadda, Antonella De Francesco, Roberto Passera, Paolo Cotogni, Marta Ossola, M.L. Amerio, Luca De Carli, and Federico Bozzetti
- Subjects
Adult ,EORTC QLQ‐C30 questionnaire ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,Longitudinal study ,Palliative care ,Kaplan-Meier Estimate ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Weight loss ,Neoplasms ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Longitudinal Studies ,Aged ,Neoplasm Staging ,Original Research ,Univariate analysis ,palliative care ,business.industry ,oncologic treatment ,Repeated measures design ,Middle Aged ,Tumor Burden ,supportive care ,Parenteral nutrition ,nutrition ,Oncology ,quality of life ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,Parenteral Nutrition, Home ,home care ,Body mass index ,Cancer Prevention - Abstract
Since there is little knowledge regarding the quality of life (QoL) of cancer patients on home parenteral nutrition (HPN), we planned a prospective, longitudinal, double‐center study to investigate the changes of QoL in these patients. One hundred and eleven adult cancer patients who were candidates for HPN following the indications of the European guidelines were consecutively enrolled. For QoL analysis, EORTC QLQ‐C30 questionnaires were filled at the HPN start and after 1, 2, 3, and 4 months, and scores changes over time were analyzed according to the univariate mixed‐effects linear model for repeated measures. Most patients had gastrointestinal cancers, were severely malnourished, and were in stage IV; two‐thirds were still receiving oncologic treatments. Median weight loss over 3 months and body mass index were 11.7% and 20.7, respectively. Median survival was 4.7 (1–42) months; 67 and 34% of patients survived 3 and 6 months, respectively. Global QoL, physical functioning, role functioning, emotional functioning, appetite loss, and fatigue scores had a statistically significant trend over time (P
- Published
- 2017