48 results on '"Makela J."'
Search Results
2. Non‐Migrating Structures in the Northern Midlatitude Thermosphere During December Solstice Using ICON/MIGHTI and FPI Observations
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Navarro, L. A., primary, Makela, J. J., additional, Forbes, J. M., additional, Harding, B. J., additional, Englert, C. R., additional, Harlander, J. M., additional, Marr, K. D., additional, Kerr, R., additional, Noto, J., additional, Wu, Q., additional, Benkhaldoun, Z., additional, Kaab, M., additional, and Immel, T. J., additional
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- 2023
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3. Multi-Layer Evolution of Acoustic-Gravity Waves and Ionospheric Disturbances Over the United States After the 2022 Hunga Tonga Volcano Eruption
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2417495, 1670664, Inchin, P. A., Bhatt, A., Cummer, S. A., Eckermann, S. D., Harding, B. J., Ma, J., Makela, J. J., Snively, J B., 2417495, 1670664, Inchin, P. A., Bhatt, A., Cummer, S. A., Eckermann, S. D., Harding, B. J., Ma, J., Makela, J. J., and Snively, J B.
- Abstract
e Hunga-Tonga Hunga-Ha'apai volcano underwent a series of large-magnitude eruptions that generated in the atmosphere. We investigate the spatial and temporal evolutions of fluctuations driven by atmospheric acoustic-gravity waves (AGWs) and, in particular, the Lamb wave modes in high spatial resolution data sets measured over the Continental United States (CONUS), complemented with data over the Americas and the Pacific. Along with >800 barometer sites, tropospheric observations, and Total Electron Content data from >3,000 receivers, we report detections of volcano-induced AGWs in mesopause and ionosphere-thermosphere airglow imagery and Fabry-Perot interferometry. We also report unique AGW signatures in the ionospheric D-region, measured using Long-Range Navigation pulsed low-frequency transmitter signals. Although we observed fluctuations over a wide range of periods and speeds, we identify Lamb wave modes exhibiting 295–345 m s−1 phase front velocities with correlated spatial variability of their amplitudes from the Earth's surface to the ionosphere. Results suggest that the Lamb wave modes, tracked by our ray-tracing modeling results, were accompanied by deep fluctuation fields coupled throughout the atmosphere, and were all largely consistent in arrival times with the sequence of eruptions over 8 hr. The ray results also highlight the importance of winds in reducing wave amplitudes at CONUS midlatitudes. The ability to identify and interpret Lamb wave modes and accompanying fluctuations on the basis of arrival times and speeds, despite complexity in their spectra and modulations by the inhomogeneous here, suggests opportunities for analysis and modeling to understand their signals to constrain features of azardous events.
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- 2023
4. MANGO: An Optical Network to Study the Dynamics of the Earth's Upper Atmosphere.
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Bhatt, A. N., Harding, B. J., Makela, J. J., Navarro, L., Lamarche, L. J., Valentic, T., Kendall, E. A., and Venkatraman, P.
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UPPER atmosphere ,ATMOSPHERIC boundary layer ,OPTICAL instruments ,MANGO ,THERMOSPHERE ,GEOPHYSICAL observations - Abstract
The Mid‐latitude All‐sky‐imaging Network for Geophysical Observations (MANGO) employs a combination of two powerful optical techniques used to observe the dynamics of Earth's upper atmosphere: wide‐field imaging and high‐resolution spectral interferometry. Both techniques observe the naturally occurring airglow emissions produced in the upper atmosphere at 630.0‐ and 557.7‐nm wavelengths. Instruments are deployed to sites across the continental United States, providing the capability to make measurements spanning mid to sub‐auroral latitudes. The current instrument suite in MANGO has six all‐sky imagers (ASIs) observing the 630.0‐nm emission (integrated between ∼200 and 400 km altitude), six ASIs observing the 557.7‐nm emission (integrated between ∼90 and 100 km altitude), and four Fabry‐Perot interferometers measuring neutral winds and temperature at these wavelengths. The deployment of additional imagers is planned. The network makes unprecedented observations of the nighttime thermosphere‐ionosphere dynamics with the expanded field‐of‐view provided by the distributed network of instruments. This paper describes the network, the instruments, the data products, and first results from this effort. Plain Language Summary: A network of cameras and optical sensing instruments is deployed across the continental United States and is used to study the processes in the earth's upper atmosphere. These processes range from response to explosive events on the sun, as well as, response to strong events in the troposphere like thunderstorms or hurricanes. This paper describes this network, how it works, how the data are being produced, and initial scientific results. Key Points: A network of red and green line cameras and Fabry‐Perot interferometers is being developed in mid‐latitude USAThe network observes dynamics in two altitude regions of the upper atmosphereThe data are used to understand the upper atmospheric response to energetic events generated in the lower atmosphere or the sun [ABSTRACT FROM AUTHOR]
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- 2023
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5. Venus Airglow Measurements and Orbiter for Seismicity (VAMOS): A SmallSat Mission Concept Study
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Komjathy, A, Krishnamoorthy, S, Lognonné, P, Didion, A, Sutin, B, Wallace, M, Cutts, J, Makela, J, Grawe, M, Bougher, S, Kenda, B, Nakazono, B, Karp, A, Lantoine, G, Rud, M, Drilleau, M, and Helbert, Jörn
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- 2018
6. Venus Airglow Measurements and Orbiter for Seismicity (VAMOS): A SmallSat Mission Concept Study
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Helbert, Jörn, Drilleau, M, Rud, M, Lantoine, G, Karp, A, Nakazono, B, Kenda, B, Bougher, S, Grawe, M, Makela, J, Cutts, J, Wallace, M, Sutin, B, Didion, A, Lognonné, P, Krishnamoorthy, S, and Komjathy, A
- Abstract
UNKNOWN
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- 2018
7. Venus Airglow Measurements and Orbiter for Seismicity (VAMOS): a mission concept study
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Helbert, Jorn, Drilleau, M, Rud, M, Lantoine, G, Karp, A, Nakazono, B, Kenda, B, Bougher, S, Grawe, M, Makela, J, Cutts, J, Wallace, M, Sutin, B, Didion, A, Lognonne, P, Krishnamoorthy, S, and Komjathy, A
- Abstract
UNKNOWN
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- 2018
8. Venus Airglow Measurements and Orbiter for Seismicity (VAMOS): a mission concept study
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Komjathy, A, Krishnamoorthy, S, Lognonne, P, Didion, A, Sutin, B, Wallace, M, Cutts, J, Makela, J, Grawe, M, Bougher, S, Kenda, B, Nakazono, B, Karp, A, Lantoine, G, Rud, M, Drilleau, M, and Helbert, Jorn
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- 2018
9. First Results on Characteristics of Nighttime MSTIDs Observed Over South Africa: Influence of Thermospheric Wind and Sporadic E
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Katamzi‐Joseph, Z. T., primary, Grawe, M. A., additional, Makela, J. J., additional, Habarulema, J. B., additional, Martinis, C., additional, and Baumgardner, J., additional
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- 2022
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10. Interhemispheric Asymmetry of the Equatorial Ionization Anomaly (EIA) on the African Sector Over 3 Years (2014–2016): Effects of Thermospheric Meridional Winds
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Loutfi, A., primary, Pitout, F., additional, Bounhir, A., additional, Benkhaldoun, Z., additional, Makela, J. J., additional, Abamni, S., additional, Zyane, K., additional, and Elfakhiri, A., additional
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- 2022
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11. IT Education in Clouds and Clouds in IT Education
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Henno, J., Jaakkola, H., Makela, J., Vrcek, Neven, Koricic, Marko, Gradisnik, Vera, Skala, Karolj, Car, Zeljka, Cicin-Sain, Marina, Babic, Snjezana, Sruk, Vlado, Skvorc, Dejan, Jovic, Alan, Gros, Stjepan, Vrdoljak, Boris, Mauher, Mladen, Tijan, Edvard, Katulic, Tihomir, Petrovic, Juraj, Grbac, Tihana Galinac, Kusen, Benjamin, Tampere University, and Computing Sciences
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113 Computer and information sciences - Abstract
The rapid development of information and communication technology (ICT) and growing participation of students in work life has already in several decades moved ICT education into 'clouds', using sources of knowledge on Internet from all around the world. The COVID pandemic has increased this process, forcing universities to restrict classroom teaching and rapidly increased student's self-study.At the same time, increase of amounts of data to be processed is constantly introducing new high-level software technologies, layers and layers of packages and libraries, deeper and more complex. This has created a new 'top-down' programming style: a new project is started with importing mass of libraries which have been used in earlier projects and only then is considered how to use them in order to solve the programming task. The self-studying ICT students see only tips of modern software icebergs and it is difficult for them to understand their working without face-to-face classroom communication where details of the 'depths' are explained. acceptedVersion
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- 2022
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12. The Ionospheric Connection Explorer Mission: Mission Goals and Design
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Immel, T. J., England, S. L., Mende, S. B., Heelis, R. A., Englert, C. R., Edelstein, J., Frey, H. U., Korpela, E. J., Taylor, E. R., Craig, W. W., Harris, S. E., Bester, M., Bust, G. S., Crowley, G., Forbes, J. M., Gérard, J.-C., Harlander, J. M., Huba, J. D., Hubert, B., Kamalabadi, F., Makela, J. J., Maute, A. I., Meier, R. R., Raftery, C., Rochus, P., Siegmund, O. H. W., Stephan, A. W., Swenson, G. R., Frey, S., Hysell, D. L., Saito, A., Rider, K. A., and Sirk, M. M.
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- 2017
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13. Machine Learning vs Human Learning
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
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- 2021
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14. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
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Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, Rohr, K, Levinson, L, Gaona, R, Uretsky, B, Maheshwari, H, Lee, D, Kinnaman, S, Singal, R, Geohas, J, Gigliotti, O, Raisinghani, A, Khurana, C, Hella, B, Kelberman, M, Voyce, S, Singh, S, Lo, E, Singh, P, Goodfellow, R, Fischer, S, Lorraine, R, Turner, T, Shanes, J, Busch, R, Broker, R, Zaniewski, M, Pounds, K, Debs-Perez, G, Ong, S, Frandsen, B, Fullington, D, Jaffrani, N, Khan, A, Lee, M, Pouzar, J, Revtyak, G, Gonzalez, J, Nakhle, S, Murillo, A, Young, D, Makam, S, Syed, M, Woolf, K, Grena, P, Alfata, S, Mahal, S, Hoffman, D, Kizhakekuttu, T, Deering, J, Bhavsar, J, Mikesell, S, Wilson, W, Wilson, V, El, S, Spinale, F, Kannarkat, V, Rao, S, Hanson, L, Bertsch, J, Gonzalez-Ortiz, E, Severino, N, Willis, J, Schock, J, Bakhtari, L, Gazmuri, R, Ansari, S, Hall, J, Mehta, A, Shealy, N, Zarich, S, Singh, D, Vora, K, Andrawis, N, Molter, D, Maron, D, Cardona, J, D'Agostino, R, Arshad, T, Samaan, R, Jones, D, Presser, D, Heath, J, Green, S, Bittar, G, Henry, S, Korn, D, Schmedtje, J, Nadar, V, Graham, B, Labroo, A, Clavijo, L, Roseman, H, Ledesma, G, Rosen, R, Dor, I, Kirby, W, Sutton, J, Eder, F, Iteld, B, Gomez-Cortes, J, Buchbinder, M, Kasper, J, Terrelonge, A, Torres, G, Jagielo, T, Alvarez, J, Handelsman, Y, Guillen, M, Richwine, R, Lewy-Alterbaum, L, Corder, C, Arvind, M, Bolshoun, D, Mikhail, M, Minton, S, Alvarado, O, Abbott, J, Cauthen, B, Welter, R, Mintz, R, Cox, J, Quick, A, Weiss, M, Dy, J, Zebrack, J, Gandelman, G, Hegde, V, Silver, M, Degregorio, M, Lawson, W, Paa, C, Bortnick, A, Krolick, M, Sotolongo, R, Cheirif, J, Kumar, P, Jetty, P, Patel, A, Kruk, M, Kobielusz-Gembala, I, Rewerska, B, Madrzejewski, A, Milewski, K, Cygler, J, Petryka-Mazurkiewicz, J, Jastrzebski, W, Korecki, J, Fil, W, Prokopczuk, J, Bochenek, A, Wujkowski, M, Witek, R, Konczakowski, P, Miekus, P, Szczasny, M, Musial, W, Cymerman, K, Lampart, J, Mikosinski, J, Szynal, S, Fares, I, Opolski, G, Mazur, S, Wozakowska-Kaplon, B, Bijata-Bronisz, R, Wierucki, L, Losa, B, Drelich, G, Konieczny, M, Starczewski, P, Pawlowicz, L, Jesionowski, P, Jurowiecki, J, Gniot, J, Czyzycki, M, Stania, K, Kucharczyk-Bauman, I, Busz-Papiez, B, Karczmarczyk, A, Sudnik, W, Koszek, A, Kolodziej, P, Skwarna, B, Jaramillo, N, Jankowski, M, Czochra, W, Kinasz, L, Miklaszewicz, B, Stasinska, T, Pluta, W, Basiak, M, Rusicka, T, Niedbal-Yahfouf, I, Popenda, G, Korzeniak, R, Mirek, A, Mariankowski, R, Wojnowski, L, Korol, M, Baszak, J, Podolec, P, Piesiewicz, W, Zurakowski, A, Luengas, C, Skura, M, Pilecki, P, Majchrzak, P, Krzyzagorska, E, Drozd, M, Kaczmarek, B, Sliwinska, T, Zelazowska, K, Sztembis, R, Landa, K, Matyszczak-Toniak, L, Strojek, K, Piepiorka, M, Malinowski, R, Gorska, M, Stolarczyk-Sowa, E, Romanowski, L, Zinka, E, Reszka, Z, Skierkowska, J, Uzunow, A, Laskowska-Derlaga, E, Puntus, E, Kosmacheva, E, Koziolova, N, Pavlov, P, Supryadkina, T, Didenko, Y, Kopylov, P, Kazakov, A, Aksentiev, S, Vishneva, E, Repin, A, Smolenskaya, O, Mantserova, O, Khrustalev, O, Privalova, E, Konstantinov, V, Boldueva, S, Ezhov, A, Chernyavsky, A, Kamalov, G, Galyavich, A, Zubeeva, G, Nechaeva, G, Shustov, S, Dzhaiani, N, Treshkur, T, Osokina, N, Panov, A, Shutemova, E, Makukhin, V, Kropotina, T, Tsyba, L, Karpov, Y, Sizova, J, Ballyuzek, M, Tarasov, N, Demchenko, E, Barbarash, O, Moiseev, V, Markov, V, Kuznetsov, V, Viktorova, I, Sergienko, I, Ermoshkina, L, Khasanov, N, Khlevchuk, T, Baglikov, A, Shalaev, S, Zonova, E, Reznik, E, Haisheva, L, Morugova, T, Lomakin, N, Vishnevsky, A, Shvarts, Y, Magnitskaya, O, Mikhailusova, M, Pavlysh, E, Libov, I, Zateyschikova, A, Kostenko, V, Edin, A, Khovaeva, Y, Zakharov, K, Stryuk, R, Khirmanov, V, Kanorskiy, S, Yakushin, S, Barabashkina, A, Li, H, Zhao, Q, Zhang, J, Ma, J, He, Y, Luo, M, Zhang, A, Zhang, N, Chai, Y, Ma, G, Wang, H, Liu, Z, He, L, Song, Z, Dong, X, Tao, L, Li, Z, Su, X, Kong, X, Niu, H, Ge, J, Luo, Z, Huang, W, Peng, D, Yuan, Z, Milanova, M, Tenev, D, Gogov, A, Karageorgiev, D, Kolchev, T, Rusev, N, Georgieva, N, Kondov, R, Rusinov, V, Petrov, I, Stanchev, G, Konteva, M, Dincheva, A, Yaneva, Z, Vatova, R, Ilieva, K, Runev, N, Kolomanov, B, Iliev, N, Tisheva, S, Chompalova, B, Tokmakova, M, Raev, D, Byanov, K, Markov, D, Mihov, L, Mihov, A, Milcheva, N, Minchev, M, Mollov, M, Borisov, B, Tihchev, T, Karakolev, V, Dimov, B, Georgiev, S, Smilov, L, Koo, B, Ahn, T, Hong, S, Yoon, J, Oh, S, Jeong, M, Kim, D, Chang, K, Kim, W, Hahn, J, Cha, K, Lee, J, Choi, S, Nam, C, Chae, I, Park, Y, Tahk, S, Shin, W, Chae, J, Kim, B, Bae, J, Park, W, Rha, S, Choi, Y, Hwang, J, Park, H, Baracioli, L, Guimaraes, F, Vasconcellos, E, Saraiva, J, Pereira, A, Santos, Q, Rossi, P, Maia, L, Madeira, M, Pereira, M, Botelho, R, Reis, G, Eliaschewitz, F, Borges, J, Nascimento, C, Fortes, J, de Souza, W, Pimentel, P, Hissa, M, Franchetti, M, Precoma, D, Ortiz, C, Hernandes, M, Saporito, W, dos Santos, F, Kormann, A, Neuenschwander, F, Dutra, O, Rassi, N, Tanajura, L, Souza, J, Junior, D, Leaes, P, Forte, A, Bonansea, T, Marin, J, Machado, B, Cerqueira, M, Silva, F, Michalaros, Y, Manenti, E, Cercato, C, Figueiredo, E, Liu, M, Wang, Y, Lee, T, Fang, C, Wu, Y, Ueng, K, Sheu, H, Lai, W, Hsieh, I, Chen, Z, Chiang, C, Shyu, K, Hsia, C, Mar, G, Chan, S, Wu, C, Tseng, W, Yeh, H, Wang, J, Hou, C, Sorokina, I, Dolzhenko, M, Horoshko, O, Karpenko, O, Rudenko, L, Vakaliuk, I, Kulyk, A, Levchenko, O, Prokhorov, O, Reshotko, D, Sorokivskyy, M, Velichko, N, Maslovskyi, V, Teliatnikova, Z, Dotsenko, S, Krakhmalova, O, Kraiz, I, Zharinova, V, Bula, L, Kaydashev, I, Molodtsov, V, Rasputina, L, Pidlisna, V, Lysunets, O, Kravchenko, A, Glushko, L, Khomazyuk, T, Svyshchenko, Y, Parkhomenko, O, Mankovsky, B, Abrahamovych, O, Yagensky, A, Stanislavchuk, M, Vasilyeva, L, Sokolova, L, Sychov, O, Tseluyko, V, Kyrychenko, I, Rishko, M, Furkalo, S, Gallo, R, Bertrand, O, Constance, C, Sussex, B, Zadra, R, Kouz, S, Chehayeb, R, Pandey, A, Dion, D, Bailey, G, Hill, L, Ramanathan, K, Dorsch, M, Nanji, A, Babapulle, M, Montigny, M, Gosselin, G, Dehghani, P, Rupka, D, Le May, M, Pichette, F, St-Maurice, F, Teefy, P, Mansour, S, Kassam, S, Cheung, S, Siega, A, O'Keefe, D, Sabbah, E, Bell, A, Chouinard, G, Wong, B, Miller, M, Gaudet, D, Lachance, P, Bata, I, Petrella, R, Gossard, D, Dumas, R, Ing, D, Boyrazian, H, Bessoudo, R, Huynh, T, Hart, R, Belle-Isle, J, Shukla, D, Kelly, A, Mazza, G, Cha, J, Henein, S, Frechette, A, Vizel, S, Liutkus, J, O'Mahony, M, Halperin, F, Kooy, J, Graham, J, Bailey, A, Wojcik, R, Wilderman, I, Turi, T, Motyovszki, A, Merkely, B, Kiss, R, Kiraly, C, Andrassy, P, Sarszegi, Z, Fulop, T, Zilahi, Z, Edes, I, Papp, A, Muller, G, Czigany, A, Zolyomi, S, Koranyi, L, Takacs, J, Juhasz, F, Benczur, B, Kancz, S, Foldi, A, Nagy, A, Bakai, J, Greschik, I, Puski, L, Nagy, L, Kirschner, R, Kuchar, R, Hajek, P, Busak, L, Michalik, D, Matyasek, I, Marusincova, I, Kucera, D, Jerabek, O, Honkova, M, Dedek, V, Rihacek, I, Kos, P, Slaby, J, Machkova, M, Zidkova, E, Elbl, L, Grunfeldova, H, Carda, J, Mrozek, V, Maly, J, Milkovic, R, Malecha, J, Skalicka, H, Oral, I, Krcova, E, Lisa, L, Belohlavek, J, Miklik, R, Cermak, O, Bednarova, J, Peroutka, Z, Spinar, J, Wilke, A, Appel, K, Taggeselle, J, Forster, A, Toursarkissian, N, Schmidt, E, Bott, J, Al-Zoebi, A, Hennig, D, Schon, N, Sauter, J, Simonis, G, Nischik, R, Rieker, W, Schenkenberger, I, Behnke, T, Klausmann, G, Jeserich, M, Trenk, D, Weigmann, I, Reuter, H, Rummel, R, von Munchhausen, C, von Engelhardt, C, Horibe, E, Shibasaki, T, Sato, T, Kakuta, T, Michishita, I, Tan, M, Ishiki, R, Aoyama, T, Higashiue, S, Niijima, Y, Idogaki, A, Hasegawa, T, Kiyosue, A, Tomobuchi, Y, Kawamitsu, K, Kawasaki, S, Hata, Y, Fukui, K, Seki, K, Takenaka, T, Abe, M, Utsu, N, Oono, A, Mitsuo, K, Sueyoshi, A, Hirohata, A, Tsujimoto, M, Ueda, O, Takase, S, Suzuki, M, Sakuragi, S, Yamamoto, F, Fujimoto, N, Kakinoki, S, Sugiura, T, Sugino, H, Nakamura, T, Kadokami, T, Uehara, H, Ono, M, Yokoya, K, Koike, A, Komatsu, S, Sonoda, M, Ueno, H, Doi, T, Takagi, Y, Fujimoto, K, Eki, Y, Okubo, M, Sasaki, K, van Eck, M, Ronner, E, The, S, van de Wal, R, Nierop, P, de Nooijer, C, Werner, H, Westendorp, I, van der Zwaan, C, Crijns, H, Cornel, J, Strikwerda, S, Bos, R, de Melker, E, Kuijper, A, Louwerenburg, H, Plomp, J, Dantzig, J, Prins, F, van Kesteren, H, Willems, F, Amoroso, G, Carnero, G, Duronto, E, Besada, D, Chacon, C, Zangroniz, P, Solis, S, Liberman, A, Sernia, V, Alvarisqueta, A, Maffei, L, Vilamajo, O, Garcia, C, Sicer, M, Muntaner, J, Bordonava, A, Albisu, J, Zanini, A, Rista, L, Hominal, M, Estrada, J, Prado, A, Gosparini, D, Schiavi, B, Castillo, A, Martinez, G, Lopez, V, Rosas, E, Lopez, G, Cantu, E, de los Rios Ibarra, M, Padilla, F, Carrasco, J, Carrillo, L, Garcia, J, Askar, A, Salinas, C, Gamba, M, Sanchez, C, Cantu, A, Sanchez, R, Madrigal, J, Urbano, R, Romo, A, Gonzalez Juanatey, J, Racugno, P, Fillat, A, de la Torre Hernandez, J, Pelaez, J, Cortada, J, Pavia, P, Navarro, M, Asenjo, R, Diaz, F, Peligero, E, 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O., Sykulski R., Rasmussen O., Andries A., Luckow A., Nielsen G., Sorensen T., Wongvipaporn C., Chamnarnphol N., Srimahachota S., Sansanayudh N., Kuanprasert S., Tresukosol D., Sookananchai B., Kanadasi M., Ozcan T., Kucuk M., Ongen Z., Okuyan E., Arat A., Acikel S., Yalcin A., Guray U., Ceyhan C., Ozer N., Arslan S., Angeras O., Johnston N., Weiderman A. -C., Bandh S., Hansen O., Larnefeldt H., Kusiak D., Lindholm C. -J., Hedman A., Erlinge D., Curiac D., Lundman P., Zucconi-Mazzini R., Aladellie L., Jensen J., Verwerft J., Vrolix M., Faes D., Striekwold H., Sinnaeve P., Timmermans P., Guedes A., Delforge M., Nimmegeers J., Stammen F., Buysschaert I., Hoffer E., Hollanders G., Vervoort G., Coussement P., de Maeseneire S., Janssens L., Gravdal S. A., Risberg K., Gullestad L., Hofseth O. D., Nilsen D., Lappegard K. T., van den Heuvel C., Gibbs C., Khusrawi A., Arora S., Tomala T., Kjaernli T., Berg-Johansen J., Hagemeier R., Skjelvan G., Colquhoun D., Amerena J., Morbey C., Hammett C., Dart A., Lehman R., Hamilton A., Worthley M., Purnell P., Whelan A., MacIsaac R., Arya K., Linjawi S., Proietto J., Prasad L., Rodriguez A., Godoy A., Rodriguez V., Berrospi P., Chavez C., Negron S., Heredia J., Medina F., Manrique H., Cabrera W., Cordova F., Quinteros T., Haro J. M., Regalado S., Guitton J., Arbanil H., Pansieri M., Decoulx E., Goube P., de Labriolle A., Labeque J. N., Range G., Cottin Y., Montalescot G., Cayla G., Danchin N., Angoulvant D., Ferrario E., Elbaz M., Dubreuil O., Fontaine C., Sorbets E., Omer H., Al-Saif S., Al-Faleh H., Al-Shehri A., El-Amin O., Alshehri H., Bazari R., Hei P., Ying M., Chan M., Wong M., Ma R., Siu S. C., Tsang C. C., Ferrario M., Assanelli E., Senni M., Piatti P., Calabro P., Urbinati S., Michisanti M., Varbella F., de Cosmo S., Trevisan R., Bellotti S., Di Pasquale G., Bongo A. S., Uguccioni M., Mannucci E., Mauro C., Ragonese M., Fresco C., Turturo M., Marcucci R., Lievano Triana M. J., Arana C., Accini J., Botero R., Muzyk-Osikowicz M., Dada F. T., Vallejo G. S., Manzur F., Isaza D., Molina D., Mesa J. G., Quintero A., Nyman K., Makela J., Strand J., Nieminen S., Taurio J., Kuusela M., Valle T., Pietila M., Kekki S., Strandberg T., Klutstein M., Greenberg G., Rozenman Y., Chorin E., Roguin A., Lewis B., Bashkin A., Tan E., Prado J. P., Ferrolino A., Babilonia N., Barbas B., Matiga G., Coching R. M., Drexel H., Brath H., Schnack C., Hanusch U., Fliesser-Gorzer E., Paulweber B., Ebenbichler C., Prager R., Huber K., Wolzt M., Auer J., Berger R., Schernthaner G. -H., Stanciulescu G., Creteanu M., Spiridon M., Dobreanu V., Vinereanu D., Iosipescu L. C., Istratoaie O., Coman I., Militaru C., Cinteza M., Sinnaeve P. R., Nicolau J. C., Kerr Saraiva J. F., Widimsky P., Kristensen S. D., Hartikainen J., Darius H., Tse H. F., Pais P., Lev E., de Luca L., Ramos Lopez G. A., Kontny F., Babilonia N. A., Zateyshchikov D. A., Ruda M., Elamin O., Kovar F., Dalby A. J., Bueno H., Chiang C. -E., Parkhomenko A., Nguyen T. Q., and Leonsson-Zachrisson M.
- Abstract
Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo
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- 2019
15. An Evaluation of the COVID-19 Pandemic and Perceived Social Distancing Policies in Relation to Planning, Selecting, and Preparing Healthy Meals
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Backer, C.D., Teunissen, L., Cuykx, I., Decorte, P., Pabian, S., Gerritsen, S., Matthys, C., Sabbah, H.A., Royen, K.V., Bergheim, I., Staltner, R., Devine, A., Sambell, R., Wallace, R., Allehdan, S.S., Alalwan, T.A., Al-Mannai, M.A., Ismail, L.C., Ouvrein, G., Poels, K., Vandebosch, H., Maldoy, K., Smits, T., Vrinten, J., Desmet, A., Teughels, N., Geuens, M., Vermeir, I., Proesmans, V., Hudders, L., De Barcellos, M.D., Ostermann, C., Brock, A.L., Favieiro, C., Trizotto, R., Stangherlin, I., Mafra, A.L., Varella, M.A.C., Valentova, J.V., Fisher, M.L., Maceacheron, M., White, K., Habib, R., Dobson, D.S., Schnettler, B., Orellana, L., Miranda-Zapata, E., Chang, A.W.-Y., Jiao, W., Tingchi, M., Liu, Grunert, K.G., Christensen, R.N., Reisch, L., Janssen, M., Abril-Ulloa, V., Encalada, L., Kamel, I., Vainio, A., Niva, M., Salmivaara, L., Makela, J., Torkkeli, K., Mai, R., Kerschke-Risch, P., Altsitsiadis, E., Stamos, A., Antronikidis, A., Tsafarakis, S., Delias, P., Rasekhi, H., Vafa, M.R., Majid, K., Eftekhari, H., Henchion, M., McCarthy, S., McCarthy, M., Micalizzi, A., Schulz, P.J., Farinosi, M., Komatsu, H., Tanaka, N., Kubota, H., Tayyem, R., Al-Awwad, N.J., Al-Bayyari, N., Ibrahim, M.O., Hammouh, F., Dashti, S., Dashti, B., Alkharaif, D., Alshatti, A., Mazedi, M.A., Hoteit, M., Mansour, R., Naim, E., Mortada, H., Gomez, Y.Y.G., Geyskens, K., Goukens, C., Roy, R., Egli, V., Morenga, L.T., Waly, M., Qasrawi, R., Hamdan, M., Sier, R.A., Al Halawa, D.A., Al Sabbah, H., Agha, H., Liria-Dominguez, M.R., Palomares, L., Sowicz, G.W., Bawadi, H., Othman, M., Pakari, J., Farha, A.A., Abu-El-ruz, R., Petrescu, D.C., Petrescu-Mag, R.M., Arion, F., Vesa, S.C., Alkhalaf, M.M., Bookari, K., Arrish, J., Rahim, Z., Kheng, R., Ngqangashe, Y., McHiza, Z.J.-R., Gonzalez-Gross, M., Pantoja-Arevalo, L., Gesteiro, E., Rios, Y., Yiga, P., Ogwok, P., Ocen, D., Bamuwamye, M., Taha, Z., Aldhaheri, A., Pineda, E., Miraldo, M., Holford, D.L., Van den Bulck, H., Language, Communication and Cognition, Corona Cooking Survey Study Group, Helsinki Institute of Sustainability Science (HELSUS), Department of Forest Sciences, Department of Social Research (2010-2017), Department of Economics and Management, Teacher Education, Department of Education, Maker@STEAM, Forest Economics, Business and Society, Consumer Studies Research Group, Marketing & Supply Chain Management, RS: GSBE Theme Human Decisions and Policy Design, and RS: GSBE Theme Data-Driven Decision-Making
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0301 basic medicine ,Gerontology ,STRESS ,Endocrinology, Diabetes and Metabolism ,Social Sciences ,B400 ,COOKING ,food selection ,0302 clinical medicine ,Endocrinology ,psychological distress ,Pandemic ,030212 general & internal medicine ,media_common ,Nutrition and Dietetics ,food preparation ,Social distance ,Multilevel model ,Brief Research Report ,Health equity ,Diabetes and Metabolism ,nutrition ,Feeling ,OBESITY ,Food selection ,3143 Nutrition ,Psychology ,TEMPO ,time availability ,Life Sciences & Biomedicine ,lcsh:Nutrition. Foods and food supply ,1001 Agricultural Biotechnology ,Food preparation ,Coronavirus disease 2019 (COVID-19) ,media_common.quotation_subject ,lcsh:TX341-641 ,D600 ,03 medical and health sciences ,Sciences sociales ,TIME PRESSURE ,030109 nutrition & dietetics ,Science & Technology ,Nutrition & Dietetics ,COVID-19 ,food literacy ,Sciences humaines ,Enabling ,Corona Cooking Survey Study Group ,Observational study ,1111 Nutrition and Dietetics ,Human medicine ,food planning ,Food Science - Abstract
ObjectivesTo examine changes in planning, selecting, and preparing healthy foods in relation to personal factors (time, money, stress) and social distancing policies during the COVID-19 crisis.MethodsUsing cross-sectional online surveys collected in 38 countries worldwide in April-June 2020 (N = 37,207, Mage 36.7 SD 14.43, 73.6% women), we compared changes in food literacy behaviors to changes in personal factors and social distancing policies, using hierarchical multiple regression analyses controlling for sociodemographic variables.ResultsIncreases in planning (4.7 SD 1.2, 4.9 SD 1.3), selecting (3.8 SD 1.7, 3.8 SD 1.7), and preparing (4.6 SD 1.3, 4.7 SD 1.3) healthy foods were found for women and men, and positively related to perceived time availability among women and stay-at-home policies for planning and preparing in women. Psychological distress was a barrier for women, and an enabler for men. COVID-19 induced financial stress was a barrier depending on various sociodemographic variables (all p < 0.01).ConclusionStay-at-home policies and feelings of having more time during COVID-19 seem to have improved food literacy among women. Stress and other social distancing policies relate to food literacy in more complex ways, highlighting the necessity of a health equity lens.
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- 2021
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16. Ionosphere-thermosphere coupling during the 22–23 June 2015 geomagnetic storm: Swarm and FPI coordinated observations above the Oukaimeden observatory
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Pitout, F., primary, Loutfi, A., additional, Bounhir, A., additional, Buchert, S.C., additional, Benkhaldoun, Z., additional, and Makela, J. J., additional
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- 2021
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17. Calibrating the sqHIMMELI v1.0 wetland methane emission model with hierarchical modeling and adaptive MCMC
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Susiluoto, J., Raivonen, M., Backman, L., Laine, M., Makela, J., Peltola, O., Vesala, T., Aalto, T., Institute for Atmospheric and Earth System Research (INAR), Viikki Plant Science Centre (ViPS), Ecosystem processes (INAR Forest Sciences), and Micrometeorology and biogeochemical cycles
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010504 meteorology & atmospheric sciences ,CLIMATE SYSTEM ,LEAF-AREA ,Flux ,Bayesian inference ,114 Physical sciences ,01 natural sciences ,Cross-validation ,CO2 EXCHANGE ,CARBON ,symbols.namesake ,NATURAL WETLANDS ,METROPOLIS ALGORITHM ,Time series ,BOREAL WETLANDS ,1172 Environmental sciences ,0105 earth and related environmental sciences ,lcsh:QE1-996.5 ,Statistical model ,Markov chain Monte Carlo ,FEN ECOSYSTEM ,04 agricultural and veterinary sciences ,15. Life on land ,Covariance ,lcsh:Geology ,Metropolis–Hastings algorithm ,13. Climate action ,040103 agronomy & agriculture ,symbols ,0401 agriculture, forestry, and fisheries ,Environmental science ,VASCULAR PLANTS ,ECOSYSTEM MODEL ,Biological system - Abstract
Estimating methane (CH4) emissions from natural wetlands is complex, and the estimates contain large uncertainties. The models used for the task are typically heavily parameterized and the parameter values are not well known. In this study, we perform a Bayesian model calibration for a new wetland CH4 emission model to improve the quality of the predictions and to understand the limitations of such models.The detailed process model that we analyze contains descriptions for CH4 production from anaerobic respiration, CH4 oxidation, and gas transportation by diffusion, ebullition, and the aerenchyma cells of vascular plants. The processes are controlled by several tunable parameters. We use a hierarchical statistical model to describe the parameters and obtain the posterior distributions of the parameters and uncertainties in the processes with adaptive Markov chain Monte Carlo (MCMC), importance resampling, and time series analysis techniques. For the estimation, the analysis utilizes measurement data from the Siikaneva flux measurement site in southern Finland. The uncertainties related to the parameters and the modeled processes are described quantitatively. At the process level, the flux measurement data are able to constrain the CH4 production processes, methane oxidation, and the different gas transport processes. The posterior covariance structures explain how the parameters and the processes are related. Additionally, the flux and flux component uncertainties are analyzed both at the annual and daily levels. The parameter posterior densities obtained provide information regarding importance of the different processes, which is also useful for development of wetland methane emission models other than the square root HelsinkI Model of MEthane buiLd-up and emIssion for peatlands (sqHIMMELI). The hierarchical modeling allows us to assess the effects of some of the parameters on an annual basis. The results of the calibration and the cross validation suggest that the early spring net primary production could be used to predict parameters affecting the annual methane production. Even though the calibration is specific to the Siikaneva site, the hierarchical modeling approach is well suited for larger-scale studies and the results of the estimation pave way for a regional or global-scale Bayesian calibration of wetland emission models.
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- 2018
18. Artificial Intelligence and Education
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Jaakkola, H., primary, Henno, J., additional, Lahti, A., additional, Jarvinen, J-P., additional, and Makela, J., additional
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- 2020
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19. Non-determinism in nowadays computing and IT
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
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- 2020
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20. Atmospheric Gravity Waves Observed in the Nightglow Following the 21 August 2017 Total Solar Eclipse
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Paulino, I., primary, Figueiredo, C. A. O. B., additional, Rodrigues, F. S., additional, Buriti, R. A., additional, Wrasse, C. M., additional, Paulino, A. R., additional, Barros, D., additional, Takahashi, H., additional, Batista, I. S., additional, Medeiros, A. F., additional, Batista, P. P., additional, Abdu, M. A., additional, de Paula, E. R., additional, Denardini, C. M., additional, Lima, L. M., additional, Cueva, R. Y.C., additional, and Makela, J. J., additional
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- 2020
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21. Thermospheric Neutral Winds Above the Oukaimeden Observatory: Effects of Geomagnetic Activity
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Loutfi, A., primary, Bounhir, A., additional, Pitout, F., additional, Benkhaldoun, Z., additional, and Makela, J. J., additional
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- 2020
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22. Get with the guidelines: management of chronic obstructive pulmonary disease in emergency departments in Europe and Australasia is sub-optimal.
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Furyk J., Stuart P., Bament J., Brown M., Greven-Garcia R., Scott M., Cheri T., Nguyen M., Wong C.-P., Wong T.W., Leung L.-P., Man C.K., Bryant M., MacDonald S., Lee T., Mahlangu M., Mountain D., Rogers I., Otto T., Saiboon I.M., Rahman N.H., Lee W.Y., Lee F.C.Y., Russell S., Lawoko C., Laribi S., Al Dandachi G., Maignan M., Hermand D., Tessier C., Roy P.-M., Bucco L., Carbone G., Cosentini R., Truta S., Hrihorisan N., Cimpoesu D., Rotaru L., Petrica A., Cojocaru M., Nica S., Tudoran R., Vecerdi C., Puticiu M., Schonberger T., Coolsma C., Baggelaar M., Fransen N., van den Brand C., Idzenga D., Maas M., Franssen M., Mackaij-Staal C., Schutte L., de Kubber M., Mignot-Evers L., Penninga-Puister U., Jansen J., Kuijten J., Bouwhuis M., Reuben A., Smith J., Ramlakhan S., Darwent M., Gagg J., Keating L., Bongale S., Hardy E., Keep J., Jarman H., Crane S., Lawal O., Hassan T., Corfield A., Reed M., Smolarsky Y., Blaschke S., Jerrentrup C., Hohenstein C., Brunnler F., Ghuysen A., Vranckx M., Ergin M., Dundar Z.D., Altuncu Y.A., Arziman I., Avcil M., Katirci Y., Kokkonen L., Valli J., Kiljunen M., Tolonen J., Kaye S., Makela J., Metsaniitty J., Vaula E., Duytsche N., Garmilla P., Kelly A.-M., Van Meer O., Keijzers G., Motiejunaite J., Jones P., Body R., Craig S., Karamercan M., Klim S., Harjola V.-P., Verschuren F., Holdgate A., Christ M., Golea A., Graham C.A., Capsec J., Barletta C., Garcia-Castrillo L., Kuan W.S., McNulty R., Tan C., Cowell D.L., Jain N., Devillecourt T., Forrester A., Lee K., Chalkley D., Gillett M., Lozzi L., Asha S., Duffy M., Watkins G., Stone R., Rosengren D., Thone J., Martin S., Orda U., Thom O., Kinnear F., Eley R., Ryan A., Morel D., May C., Thomson G., Smith S., Smith R., Maclean A., Grummisch M., Meyer A., Meek R., Rosengarten P., Chan B., Haythorne H., Archer P., Wilson K., Knott J., Ritchie P., Furyk J., Stuart P., Bament J., Brown M., Greven-Garcia R., Scott M., Cheri T., Nguyen M., Wong C.-P., Wong T.W., Leung L.-P., Man C.K., Bryant M., MacDonald S., Lee T., Mahlangu M., Mountain D., Rogers I., Otto T., Saiboon I.M., Rahman N.H., Lee W.Y., Lee F.C.Y., Russell S., Lawoko C., Laribi S., Al Dandachi G., Maignan M., Hermand D., Tessier C., Roy P.-M., Bucco L., Carbone G., Cosentini R., Truta S., Hrihorisan N., Cimpoesu D., Rotaru L., Petrica A., Cojocaru M., Nica S., Tudoran R., Vecerdi C., Puticiu M., Schonberger T., Coolsma C., Baggelaar M., Fransen N., van den Brand C., Idzenga D., Maas M., Franssen M., Mackaij-Staal C., Schutte L., de Kubber M., Mignot-Evers L., Penninga-Puister U., Jansen J., Kuijten J., Bouwhuis M., Reuben A., Smith J., Ramlakhan S., Darwent M., Gagg J., Keating L., Bongale S., Hardy E., Keep J., Jarman H., Crane S., Lawal O., Hassan T., Corfield A., Reed M., Smolarsky Y., Blaschke S., Jerrentrup C., Hohenstein C., Brunnler F., Ghuysen A., Vranckx M., Ergin M., Dundar Z.D., Altuncu Y.A., Arziman I., Avcil M., Katirci Y., Kokkonen L., Valli J., Kiljunen M., Tolonen J., Kaye S., Makela J., Metsaniitty J., Vaula E., Duytsche N., Garmilla P., Kelly A.-M., Van Meer O., Keijzers G., Motiejunaite J., Jones P., Body R., Craig S., Karamercan M., Klim S., Harjola V.-P., Verschuren F., Holdgate A., Christ M., Golea A., Graham C.A., Capsec J., Barletta C., Garcia-Castrillo L., Kuan W.S., McNulty R., Tan C., Cowell D.L., Jain N., Devillecourt T., Forrester A., Lee K., Chalkley D., Gillett M., Lozzi L., Asha S., Duffy M., Watkins G., Stone R., Rosengren D., Thone J., Martin S., Orda U., Thom O., Kinnear F., Eley R., Ryan A., Morel D., May C., Thomson G., Smith S., Smith R., Maclean A., Grummisch M., Meyer A., Meek R., Rosengarten P., Chan B., Haythorne H., Archer P., Wilson K., Knott J., and Ritchie P.
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- 2020
23. Teaching for virtual work
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
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- 2019
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24. Artificial Intelligence Yesterday, Today and Tomorrow
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Jaakkola, H., primary, Henno, J., additional, Makela, J., additional, and Thalheim, B., additional
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- 2019
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25. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts
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Santos, S., Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sorensen, T. I. A., Lawlor, D. A., Gaillard, R., Jaddoe, V. W. V., Santos, S., Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sorensen, T. I. A., Lawlor, D. A., Gaillard, R., and Jaddoe, V. W. V.
- Abstract
Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.
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- 2019
26. Impact of maternal body mass index and gestational weight gain on pregnancy complications:an individual participant data meta-analysis of European, North American and Australian cohorts
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Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sørensen, T. I. A., Lawlor, D. A., Gaillard, R., Jaddoe, V. W. V., Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sørensen, T. I. A., Lawlor, D. A., Gaillard, R., and Jaddoe, V. W. V.
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- 2019
27. Adjusting university education with workspace training and self-education
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
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- 2018
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28. Role of the user in information systems development
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Jaakkola, H., primary, Thalheim, B., additional, Henno, J., additional, Makela, J., additional, and Keto, H., additional
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- 2018
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29. Nightside Detection of a Large‐Scale Thermospheric Wave Generated by a Solar Eclipse
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Harding, B. J., primary, Drob, D. P., additional, Buriti, R. A., additional, and Makela, J. J., additional
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- 2018
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30. Identification of dynamic undifferentiated cell states within the male germline
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La, HM, Makela, J-A, Chan, A-L, Rossello, FJ, Nefzger, CM, Legrand, JMD, De Seram, M, Polo, JM, Hobbs, RM, La, HM, Makela, J-A, Chan, A-L, Rossello, FJ, Nefzger, CM, Legrand, JMD, De Seram, M, Polo, JM, and Hobbs, RM
- Abstract
The role of stem cells in tissue maintenance is appreciated and hierarchical models of stem cell self-renewal and differentiation often proposed. Stem cell activity in the male germline is restricted to undifferentiated A-type spermatogonia (Aundiff); however, only a fraction of this population act as stem cells in undisturbed testis and Aundiff hierarchy remains contentious. Through newly developed compound reporter mice, here we define molecular signatures of self-renewing and differentiation-primed adult Aundiff fractions and dissect Aundiff heterogeneity by single-cell analysis. We uncover an unappreciated population within the self-renewing Aundiff fraction marked by expression of embryonic patterning genes and homeodomain transcription factor PDX1. Importantly, we find that PDX1 marks a population with potent stem cell capacity unique to mature, homeostatic testis and demonstrate dynamic interconversion between PDX1+ and PDX1− Aundiff states upon transplant and culture. We conclude that Aundiff exist in a series of dynamic cell states with distinct function and provide evidence that stability of such states is dictated by niche-derived cues.
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- 2018
31. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania
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Moreira da Silva Santos, Susana, Eekhout, I, Voerman, Ellis, Gaillard, Romy, Barros, H, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costet, N, Crozier, S, Doyon, M, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, Gagliardi, L, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Jusko, TA, Karvonen, AM, Koletzko, B, Kupers, LK, Lagstrom, H, Lawlor, DA, Lehmann, I, Lopez-Espinosa, MJ, Magnus, P, Majewska, R, Makela, J, Manios, Y, McDonald, SW, Mommers, M, Morgen, CS, Moschonis, G, Murinova, L, Newnham, J, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, A, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Santa-Marina, L, dos Santos, AC, Smit, HA, Sorensen, TIA, Standl, M, Stanislawski, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Gelder, M, Rossem, L, Berg, A, Vrijheid, M, Vrijkotte, TGM, Zvinchuk, O, van Buuren, S, Jaddoe, Vincent, Moreira da Silva Santos, Susana, Eekhout, I, Voerman, Ellis, Gaillard, Romy, Barros, H, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costet, N, Crozier, S, Doyon, M, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, Gagliardi, L, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Jusko, TA, Karvonen, AM, Koletzko, B, Kupers, LK, Lagstrom, H, Lawlor, DA, Lehmann, I, Lopez-Espinosa, MJ, Magnus, P, Majewska, R, Makela, J, Manios, Y, McDonald, SW, Mommers, M, Morgen, CS, Moschonis, G, Murinova, L, Newnham, J, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, A, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Santa-Marina, L, dos Santos, AC, Smit, HA, Sorensen, TIA, Standl, M, Stanislawski, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Gelder, M, Rossem, L, Berg, A, Vrijheid, M, Vrijkotte, TGM, Zvinchuk, O, van Buuren, S, and Jaddoe, Vincent
- Published
- 2018
32. Recent Advances in Atmospheric, Solar-Terrestrial Physics and Space Weather From a North-South network of Scientists [2006-2016] Part B : Results and Capacity building
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Amory Mazaudier, Christine, Fleury, R., Petitdidier, M., Soula, S., Masson, F., GIRGEA team, Davila, J., Doherty, P., Elias, Ana Georgina, Gadimova, S., Makela, J., Naba, B., Radicella, S., Richardson, J., Touzani, A., Laboratoire de Physique des Plasmas (LPP), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Universités-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Abdus Salam International Centre for Theoretical Physics [Trieste] (ICTP), Lab-STICC_IMTA_MOM_PIM, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT), Département Micro-Ondes (IMT Atlantique - MO), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées
- Subjects
International Heliophysical Year ,purl.org/becyt/ford/1 [https] ,purl.org/becyt/ford/1.5 [https] ,International Space Weather Initiative Project ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,Space Weather ,Ionosphere ,Meteorología y Ciencias Atmosféricas ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,CIENCIAS NATURALES Y EXACTAS ,Ciencias de la Tierra y relacionadas con el Medio Ambiente - Abstract
This paper reviews scientific advances achieved by a North-South network between 2006 and 2016. These scientific advances concern solar terrestrial physics, atmospheric physics and space weather. This part B is devoted tothe results and capacity building. Our network began in 1991, in solar terrestrial physics, by our participation in the two projects: InternationalEquatorial Electrojet Year IEEY [1992-1993] and International Heliophysical Year IHY [2007-2009]. These two projects were mainly focused on the equatorial ionosphere in Africa. In Atmospheric physics our research focused on gravity waves in the framework of the African Multidisciplinary Monsoon Analysis project n°1 [2005-2009 ], on hydrology in the Congo river basin and on lightning in Central Africa, the most lightning part of the world. In Vietnam the study of a broad climate data base highlighted global warming. In space weather, our results essentially concern the impact of solar events on global navigation satellite system GNSS and on the effects of solar events on the circulation of electric currents in the earth (GIC). This research began in the framework of the international space weather initiative project ISWI [2010-2012]. Finally, all these scientific projects have enabled young scientists from the South to publish original results and to obtain positions in their countries. These projects have also crossed disciplinary boundaries and defined a more diversified education which led to the training of specialists in a specific field with knowledge of related scientific fields. Fil: Amory Mazaudier, Christine. Universite Pierre et Marie Curie; Francia. Abdus Salam International Centre for Theoretical Physics; Italia Fil: Fleury, R.. Institut Mines-Telecom Atlantique; Francia Fil: Petitdidier, M.. Université de Versailles-Saint-Quentin-en-Yvelines; Francia. Centre National de la Recherche Scientifique; Francia Fil: Soula, S.. Université de Toulouse; Francia Fil: Masson, F.. Institut de Physique du Globe de Strasbourg; Francia Fil: GIRGEA team. Universite Pierre et Marie Curie; Francia Fil: Davila, J.. National Aeronautics and Space Administration; Estados Unidos Fil: Doherty, P.. Boston University; Estados Unidos. Boston College; Estados Unidos Fil: Elias, Ana Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Física; Argentina Fil: Gadimova, S.. Office for Outer Space Affairs, United Nations Office at Vienna; Suiza Fil: Makela, J.. University of Illinois at Urbana; Estados Unidos Fil: Naba, B.. Abdus Salam International Centre for Theoretical Physics; Italia Fil: Radicella, S.. Abdus Salam International Centre for Theoretical Physics; Italia Fil: Richardson, J.. Massachusetts Institute of Technology; Estados Unidos Fil: Touzani, A.. African Regional Centre for Space Science and Technology Education; Nigeria
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- 2017
33. The educators' telescope to the future of technology
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Jaakkola, H., primary, Henno, J., additional, Thalheim, B., additional, and Makela, J., additional
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- 2017
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34. Today is the future of yesterday; what is the future of today?
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Jaakkola, H., primary, Henno, J., additional, Makela, J., additional, and Thalheim, B., additional
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- 2017
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35. Developing curiosity and multimedia skills with programming experiments
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
- Published
- 2017
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36. Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence
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Kruis, W., Kardalinos, V., Eisenbach, T., Lukas, M., Vich, T., Bunganic, I., Pokrotnieks, J., Derova, J., Kondrackiene, J., Safadi, R., Tuculanu, D., Tulassay, Z., Banai, J., Curtin, A., Dorofeyev, A. E., Zakko, S. F., Ferreira, N., Bjorck, S., Alonso, M. M. Diez, Makela, J., Talley, N. J., Dilger, K., Greinwald, R., Mohrbacher, R., Spiller, R., Kruis, W., Kardalinos, V., Eisenbach, T., Lukas, M., Vich, T., Bunganic, I., Pokrotnieks, J., Derova, J., Kondrackiene, J., Safadi, R., Tuculanu, D., Tulassay, Z., Banai, J., Curtin, A., Dorofeyev, A. E., Zakko, S. F., Ferreira, N., Bjorck, S., Alonso, M. M. Diez, Makela, J., Talley, N. J., Dilger, K., Greinwald, R., Mohrbacher, R., and Spiller, R.
- Abstract
Background: Previous studies have reached conflicting conclusions regarding the efficacy of mesalazine in the prevention of recurrent diverticulitis. Aim: To investigate the efficacy and safety of mesalazine granules in the prevention of recurrence of diverticulitis after acute uncomplicated diverticulitis. Methods: Two phase 3, randomised, placebo-controlled, double-blind multicentre trials (SAG-37 and SAG-51) investigated mesalazine granules in patients with prior episodes (<6 months) of uncomplicated left-sided diverticulitis. Patients were randomised to receive either 3 g mesalazine once daily or placebo (SAG-37, n=345) or to receive either 1.5 g mesalazine once daily, 3 g once daily or placebo for 96 weeks (SAG-51, n=330). The primary endpoint was the proportion of recurrence-free patients during 48 weeks (SAG-37 and SAG-51) or 96 weeks (SAG-51) of treatment. Results: Mesalazine did not increase the proportion of recurrence-free patients over 48 or 96 weeks compared to placebo. In SAG-37, the proportion of recurrence-free patients during 48 weeks was 67.9% with mesalazine and 74.4% with placebo (P=.226). In SAG-51, the proportion of recurrence-free patients over 48 weeks was 46.0% with 1.5 g mesalazine, 52.0% with 3 g mesalazine and 58.0% with placebo (P=.860 for 3 g mesalazine vs placebo) and over 96 weeks 6.9%, 9.8% and 23.1% respectively (P=.980 for 3 g mesalazine vs placebo). Patients with only one diverticulitis episode in the year prior to study entry had a lower recurrence risk compared to >1 episode. Safety data revealed no new adverse events. Conclusion: Mesalazine was not superior to placebo in preventing recurrence of diverticulitis.
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- 2017
37. Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes
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Chan, A-L, La, HM, Legrand, JMD, Makela, J-A, Eichenlaub, M, De Seram, M, Ramialison, M, Hobbs, RM, Chan, A-L, La, HM, Legrand, JMD, Makela, J-A, Eichenlaub, M, De Seram, M, Ramialison, M, and Hobbs, RM
- Abstract
Sustained spermatogenesis in adult males and fertility recovery following germ cell depletion are dependent on undifferentiated spermatogonia. We previously demonstrated a key role for the transcription factor SALL4 in spermatogonial differentiation. However, whether SALL4 has broader roles within spermatogonia remains unclear despite its ability to co-regulate genes with PLZF, a transcription factor required for undifferentiated cell maintenance. Through development of inducible knockout models, we show that short-term integrity of differentiating but not undifferentiated populations requires SALL4. However, SALL4 loss was associated with long-term functional decline of undifferentiated spermatogonia and disrupted stem cell-driven regeneration. Mechanistically, SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 and Dusp4. Aberrant Foxl1 activation inhibited undifferentiated cell growth and survival, while DUSP4 suppressed self-renewal pathways. We therefore uncover an essential role for SALL4 in maintenance of undifferentiated spermatogonial activity and identify regulatory pathways critical for germline stem cell function.
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- 2017
38. Researcher measured — Towards a measurement-driven academia
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Jaakkola, H., primary, Henno, J., additional, Makela, J., additional, and Ahonen, K., additional
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- 2016
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39. Use of ‘learning analytics’
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
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- 2016
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40. The digitalization push in universities
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Jaakkola, H., primary, Aramo-Immonen, H., additional, Henno, J., additional, and Makela, J., additional
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- 2016
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41. Observations of storm time midlatitude ion‐neutral coupling using SuperDARN radars and NATION Fabry‐Perot interferometers
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Joshi, P. P., primary, H. Baker, J. B., additional, Ruohoniemi, J. M., additional, Makela, J. J., additional, Fisher, D. J., additional, Harding, B. J., additional, Frissell, N. A., additional, and Thomas, E. G., additional
- Published
- 2015
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42. Modeling the ionospheric impact of tsunami-driven gravity waves with SAMI3: Conjugate effects
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Huba, J. D., primary, Drob, D. P., additional, Wu, T.-W., additional, and Makela, J. J., additional
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- 2015
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43. Project- and product-oriented course
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Henno, J., primary, Jaakkola, H., additional, and Makela, J., additional
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- 2015
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44. Electrostatic reconnection in the ionosphere
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Huba, J. D., primary, Wu, T.‐W., additional, and Makela, J. J., additional
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- 2015
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45. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
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Deepak L Bhatt, Philippe Gabriel Steg, Shamir R Mehta, Lawrence A Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Diaz, Shinya Goto, Stefan K James, Kausik K Ray, Alexander N Parkhomenko, Mikhail N Kosiborod, Darren K McGuire, Robert A Harrington, Vladimir Santos, Ashit Jain, Irina Lendel, Michael Russo, W H Haught, Manuel Bouza, Harinder Gogia, Supratim Banerjee, George Kichura, Louis Kantaros, Francisco Padron, Rakesh Passi, Jay Stone, Michael Pursley, Michael D'Urso, Timothy Gardner, James Bennett, Khaled Nour, Satinder Saini, Wenwu Zhang, Dharam Kumbhani, Dustin Thomas, Dominick Angiolillo, Barry Bertolet, Amaury Roman-Miranda, Robert Black, Ramin Manshadi, Carlos Vaca, Antonio Blanco, Mark Napoli, David Brabham, Ayim Akyea-Djamson, Pratik Desai, Sudhir Prasada, Ajit Khaira, Leslie Forgosh, Ira Lieber, Guillermo Umpierrez, Dinesh Singal, Juan Londono, Neil Fraser, Jose Ruiz, Damaris Vega, Lilia Rodriguez, Christopher Brown, Faizullah Syed, Guarav Aggarwala, William Eaves, Michael Foster, Dinesh Gupta, David Avino, Wail Asfour, Glen Tonnessen, Xue-Qiao Zhao, Narendra Singh, Andrew Brockmyre, Norman Lepor, Nicolas Shammas, David Blick, Steven Hearne, John Prodafikas, Edgar Carell, Mark Izzo, Amin Karim, Bosh Zakhary, Mahmoud Atieh, Steven Leichter, Charles Meadows, David Hotchkiss, Mazen Abu-Fadel, Alan Wiseman, Jeffrey Bander, Mahesh Shah, Subhash Banerjee, Ricky Ganim, Karen Sopko, Misal Khan, Ramon Lloret, Troy Weirick, Rajendra Mehta, Udho Thadani, Anuj Bhargava, Mikhail Kosiborod, Jaynier Moya, Cezar Staniloae, Yamirka D Guerra, Anil Chhabra, Douglas Kosmicki, Wassim Shaheen, Akber Mohammed, J'Cinda Bitters, Jan Pattanayak, Julian Javier, Sunny Srivastava, Roland Phillips, Jessie Al-Amin, Michael Lillestol, Patrick Simpson, Lydie Hazan, Amit Amin, Gopi Shah, Denes Korpas, Bruce Platt, Jim Dickert, Orlando Puente, Louis Hiotis, Timothy Doyle, Raj Rajan, Alan Meholick, Christian Gring, Elie Hage-Korban, Robert Feldman, Harry Colfer, Samuel Butman, Malcolm Foster, Terence Hart, Randall Huling, Shervin Eshaghian, Ofsman Quintana, Deanna Cheung, Franklin Handel, Mara Rodriguez, David Suh, Paul Gordon, Gregg Pressman, Michael Bauer, William French, Mark Barettella, Sridhar Chatrathi, Damodhar Suresh, Ronald Goldberg, Mark Huth, Liwa Younis, Aref Rahman, Richard Mascolo, Michelle Welch, Randeep Suneja, Stephen Smith, Scott Shurmur, John Agaiby, Ahmad Jingo, Janice Johnston, Mary Beth, Anthony Vlastaris, Susan Kemp, Hamid Taheri, Edward Pereira, Michael Deyoung, Zafir Hawa, Ray Smith, Thomas Galski, Samer Garas, M Reddy, Susheel Sharma, Joeseph Hargrove, Charles Treasure, Ronald Emerson, Tariq Haddad, Kathryn Rohr, Larry Levinson, Raul Gaona, Barry Uretsky, Hiralal Maheshwari, Denny Lee, Stephanie Kinnaman, Robert Singal, Jeffrey Geohas, Osvaldo Gigliotti, Ajit Raisinghani, Charanjit Khurana, Brent Hella, Michael Kelberman, Steven Voyce, Sanjay Singh, Eric Lo, Pradeep Singh, Ross Goodfellow, Stuart Fischer, Richard Lorraine, Traci Turner, Jeffrey Shanes, Robert Busch, Robert Broker, Michelle Zaniewski, Kevin Pounds, Giselle Debs-Perez, Stephen Ong, Brad Frandsen, Douglas Fullington, Naseem Jaffrani, Ahtaram Khan, Marcus Lee, Joe Pouzar, George Revtyak, Julian Gonzalez, Samer Nakhle, Abel Murillo, Douglas Young, Sashi Makam, Mushtaq Syed, Kevin Woolf, Paul Grena, Sarab Alfata, Sharan Mahal, David Hoffman, Tinoy Kizhakekuttu, Joseph Deering, Janak Bhavsar, Scott Mikesell, William Wilson, Vance Wilson, Salah El, Francis Spinale, Vinod Kannarkat, Sunder Rao, Lenita Hanson, John Bertsch, Elena Gonzalez-Ortiz, Norma Severino, John Willis, Joel Schock, Ladan Bakhtari, Raul Gazmuri, Saadat Ansari, Jason Hall, Arvind Mehta, Neal Shealy, Stuart Zarich, Deovrat Singh, Kishor Vora, Nabil Andrawis, Darron Molter, David Maron, Jose Cardona, Ronald D'Agostino, Tamjeed Arshad, Rodney Samaan, David Jones, Dale Presser, John Heath, Sandy Green, George Bittar, Sheldon Henry, David Korn, John Schmedtje, Venkatesh Nadar, Bruce Graham, Ajay Labroo, Leonardo Clavijo, Hal Roseman, Gilbert Ledesma, Robert Rosen, Isaac Dor, William Kirby, Jennefer Sutton, Frank Eder, Bruce Iteld, Jose Gomez-Cortes, Maurice Buchbinder, Joseph Kasper, Antonio Terrelonge, Gustavo Torres, Ted Jagielo, Jose Alvarez, Yehuda Handelsman, Mario Guillen, Randall Richwine, Lorena Lewy-Alterbaum, Clinton Corder, Moogali Arvind, David Bolshoun, Magdy Mikhail, Stephen Minton, Odilon Alvarado, J Abbott, Brett Cauthen, Ryan Welter, Randy Mintz, John Cox, Annette Quick, Melvin Weiss, Johnny Dy, James Zebrack, Glenn Gandelman, Vinayak Hegde, Marc Silver, Michele DeGregorio, William Lawson, Christopher Paa, Anna Bortnick, Merrill Krolick, Rodolfo Sotolongo, Jorge Cheirif, Priya Kumar, Preetham Jetty, Ambar Patel, Mariusz Kruk, Iwona Kobielusz-Gembala, Barbara Rewerska, Adam Madrzejewski, Krzysztof Milewski, Jerzy Cygler, Joanna Petryka-Mazurkiewicz, Waldemar Jastrzebski, Janusz Korecki, Wojciech Fil, Janusz Prokopczuk, Anna Bochenek, Marek Wujkowski, Robert Witek, Piotr Konczakowski, Pawel Miekus, Marcin Szczasny, Wlodzimierz Musial, Krzysztof Cymerman, Jacek Lampart, Jacek Mikosinski, Slawomir Szynal, Issa Fares, Grzegorz Opolski, Stanislaw Mazur, Beata Wozakowska-Kaplon, Renata Bijata-Bronisz, Lukasz Wierucki, Beata Losa, Grzegorz Drelich, Marek Konieczny, Pawel Starczewski, Lidia Pawlowicz, Pawel Jesionowski, Jaroslaw Jurowiecki, Jacek Gniot, Mariusz Czyzycki, Karol Stania, Izabela Kucharczyk-Bauman, Benita Busz-Papiez, Agnieszka Karczmarczyk, Wanda Sudnik, Alina Koszek, Piotr Kolodziej, Bartosz Skwarna, Nicolás Jaramillo, Maciej Jankowski, Wojciech Czochra, Leszek Kinasz, Beata Miklaszewicz, Teresa Stasinska, Wladyslaw Pluta, Marcin Basiak, Teresa Rusicka, Izabela Niedbal-Yahfouf, Grazyna Popenda, Romuald Korzeniak, Agnieszka Mirek, Rafal Mariankowski, Lukasz Wojnowski, Marek Korol, Jacek Baszak, Piotr Podolec, Wojciech Piesiewicz, Aleksander Zurakowski, Carlos Luengas, Marek Skura, Piotr Pilecki, Piotr Majchrzak, Ewa Krzyzagórska, Marcin Drozd, Barbara Kaczmarek, Teresa Sliwinska, Katarzyna Zelazowska, Rafal Sztembis, Katarzyna Landa, Lidia Matyszczak-Toniak, Krzysztof Strojek, Marek Piepiorka, Robert Malinowski, Maria Górska, Edyta Stolarczyk-Sowa, Leszek Romanowski, Elzbieta Zinka, Zygfryd Reszka, Joanna Skierkowska, Anna Uzunow, Ewa Laskowska-Derlaga, Ekaterina Puntus, Elena D Kosmacheva, Natalia Koziolova, Prokhor Pavlov, Tatiana Supryadkina, Yury Didenko, Philipp Kopylov, Andrei Kazakov, Sergei Aksentiev, Elena Vishneva, Alexey Repin, Olga Smolenskaya, Olga Mantserova, Oleg Khrustalev, Elena Privalova, Vladimir Konstantinov, Svetlana Boldueva, Andrey Ezhov, Alexander Chernyavsky, Gadel Kamalov, Albert Galyavich, Galina Zubeeva, Galina Nechaeva, Sergey Shustov, Nino Dzhaiani, Tatiana Treshkur, Nataliya Osokina, Alexey Panov, Elena Shutemova, Valeriy Makukhin, Tatiana Kropotina, Larisa Tsyba, Yuri Karpov, J M Sizova, Marina Ballyuzek, Nikolay Tarasov, Elena Demchenko, Olga Barbarash, Valentin Moiseev, Valentin Markov, Vadim Kuznetsov, Inna Viktorova, Igor Sergienko, Lyudmila Ermoshkina, Niyaz Khasanov, Tatiana Khlevchuk, Andrey Baglikov, Sergey Shalaev, Elena Zonova, Elena Reznik, Larisa Haisheva, Tatyana Morugova, Nikita Lomakin, Alexander Vishnevsky, Yuri Shvarts, Olga Magnitskaya, Marina Mikhailusova, Elena Pavlysh, Igor Libov, Anna Zateyschikova, Victor Kostenko, Anton Edin, Yaroslava Khovaeva, Konstantin Zakharov, Raisa Stryuk, Vladimir Khirmanov, Sergey Kanorskiy, Sergey Yakushin, Anna Barabashkina, Hongwei Li, Qiang Zhao, Jian Zhang, Jianhua Ma, Yong He, Ming Luo, Aidong Zhang, Ningru Zhang, Yingru Chai, Genshan Ma, Hao Wang, Zhigang Liu, Lanjie He, Zhifang Song, Xiaolin Dong, Liang Tao, Zhanquan Li, Xi Su, Xiangqing Kong, Heping Niu, Junbo Ge, Zhurong Luo, Wenjun Huang, Daoquan Peng, Zuyi Yuan, Maria Milanova, Doncho Tenev, Antoni Gogov, Dimitar Karageorgiev, Todor Kolchev, Nikolay Rusev, Nikolina Georgieva, Rumen Kondov, Veselin Rusinov, Ivo Petrov, Georgi Stanchev, Mariana Konteva, Adriana Dincheva, Zdravka Yaneva, Ralitsa Vatova, Katya Ilieva, Nikolai Runev, Borislav Kolomanov, Ivan Petrov, Nikolay Iliev, Snezhanka Tisheva, Boryana Chompalova, Maria Tokmakova, Dimitar Raev, Kolyo Byanov, Dimitar Markov, Lenko Mihov, Atanas Mihov, Nora Milcheva, Milen Minchev, Mihail Mollov, Borislav Borisov, Tihomir Tihchev, Venelin Karakolev, Bojidar Dimov, Svetoslav Georgiev, Lachezar Smilov, Bon K Koo, Taehoon Ahn, Soon J Hong, Junghan Yoon, Seok K Oh, Myung H Jeong, Doo-Il Kim, Kiyuk Chang, Weon Kim, Joo-Yong Hahn, Kwang S Cha, Jung-Hee Lee, Si-Wan Choi, Chang-Wook Nam, In-Ho Chae, Yong H Park, Seung-Jea Tahk, Won-Yong Shin, Jei-Keon Chae, Byung J Kim, Jang-Whan Bae, Woo J Park, Seung W Rha, Young J Choi, Jin-Yong Hwang, Hun S Park, Luciano Baracioli, Fabio Guimaraes, Eduardo Vasconcellos, José Saraiva, Adamastor Pereira, Queulla Santos, Paulo Rossi, Lilia Maia, Miguel Madeira, Marcio Pereira, Roberto Botelho, Gilmar Reis, Freddy Eliaschewitz, Joao Borges, Carlos Nascimento, Jose A Fortes, Weimar de Souza, Pedro Pimentel, Miguel Hissa, Marcos Franchetti, Dalton Precoma, Costantino Ortiz, Mauro Hernandes, Wladmir Saporito, Fabio R dos Santos, Adrian Kormann, Fernando Neuenschwander, Oscar Dutra, Nelson Rassi, Luiz Tanajura, Juliana Souza, Delcio S Junior, Paulo Leaes, Adriana Forte, Teresa C Bonansea, Jose Marin, Bruno Machado, Maria J Cerqueira, Frederico Silva, Yorghos Michalaros, Euler Manenti, Cintia Cercato, Estevao Figueiredo, Ming-En Liu, Yi-Chih Wang, Tsung-Ming Lee, Chih Fang, Yen-Wen Wu, Kwo-Chang Ueng, Huey-Herng Sheu, Wen T Lai, I-Chang Hsieh, Zhih-Cherng Chen, Mu-Jang Lee, Chern Chiang, Kou-Gi Shyu, Chien-Hsun Hsia, Guang-Yuan Mar, Shih-Hung Chan, Chih-Cheng Wu, Wei-Kung Tseng, Kuan-Cheng Chang, Hung-I Yeh, Ji-Hung Wang, Charles Hou, Inna Sorokina, Maryna Dolzhenko, Olha Horoshko, Oleksandr Karpenko, Leonid Rudenko, Igor Vakaliuk, Anna Kulyk, 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Giovanni Amoroso, Gabriela Carnero, Ernesto Duronto, Diego Besada, Carolina Chacon, Pedro Zangroniz, Silvana Solis, Alberto Liberman, Virginia Sernia, Andres Alvarisqueta, Laura Maffei, Oscar G Vilamajo, Celso García, Maximiliano Sicer, Juan Muntaner, Anselmo Bordonava, Juan Albisu, Alejandra Zanini, Lucas Rista, Miguel Hominal, José N Estrada, Aldo Prado, Diego M Gosparini, Beatriz Schiavi, Armando G Castillo, José G Ruíz, Guillermo R Martinez, Víctor G López, Enrique L Rosas, Gabriel R Lopez, Elias G Cantu, Manuel de los Ríos Ibarra, Francisco P Padilla, Jose P Carrasco, Luis V Carrillo, Joel D García, Alfredo N Askar, Carlos A Salinas, Marco A Gamba, Carlos G Sanchez, Arnulfo G Cantú, Raul V Sánchez, Jaime C Madrigal, Rafael H Urbano, Andrés Í Romo, José R González Juanatey, Paolo Racugno, Angel C Fillat, José M de la Torre Hernández, Juan A Peláez, Jorge B Cortada, Pablo G Pavia, Manuel J Navarro, Roberto M Asenjo, Francisco F Díaz, Eduard B Peligero, Fernando A Manterola, Antonio F Ortiz, Juan D Mediavilla García, Francisco M Ortuño, Tomás R Vera, Alfonso S González, Jaime A Viñas, Francisco J Fernández Portales, Petra S Mayordomo, Francisco B Ojeda, Antonio R Domínguez, Rosa S González, Diego B Guerrero, Juan M Ruiz Nodar, Xavier G Marimon, José G Margáez, Roberto M Aguilera, José F Díaz Fernández, José L Zamorano Gómez, Vicente B González, Bruno G del Blanco, Ignacio P Pérez, Mercé R Moreno, Ainhoa R Ereño, José A García Lledó, Juan Prieto, Alex Villablanca, Carlos Raffo, Christian Pincetti, Carlos Conejeros, Oscar Roman, Manuel Rodriguez, Paola Varleta, Cindy Goldberg, Jorge Sandoval, German Arriagada, Lucio Leon, Sergio Potthoff, Jorge Cobos, Christian Figueroa, Ellen Makotoko, Nyda Fourie, Lesley Burgess, Hendrik Nortje, Rust Theron, Perumal Pillai, Naresh Ranjith, Julien Trokis, Soobramoney Pillay, Jeevren Reddy, Theema Nunkoo, Cornelia Kapp, Dorothea Urbach, Lawrence Distiller, Adrian Horak, Louis van Zyl, Kathleen Coetzee, Zelda Punt, Junaid Bayat, 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Nicolas Danchin, Denis Angoulvant, Emile Ferrario, Meyer Elbaz, Olivier Dubreuil, Philippe G Steg, Caroline Fontaine, Emmanuel Sorbets, Hafiz Omer, Shukri Al-Saif, Hussam Al-Faleh, Abdullah Al-Shehri, Halia Alshehri, Rasha Bazari, Pak Hei, Man Ying, Michael Chan, Michelle Wong, Ronald Ma, Shing C Siu, Chiu C Tsang, Maurizio Ferrario, Emilio Assanelli, Michele Senni, Piermarco Piatti, Paolo Calabrò, Stefano Urbinati, Massimo Michisanti, Ferdinando Varbella, Salvatore de Cosmo, Roberto Trevisan, Sandro Bellotti, Giuseppe Di Pasquale, Angelo S Bongo, Massimo Uguccioni, Edoardo Mannucci, Ciro Mauro, Mauro Ragonese, Claudio Fresco, Maurizio Turturo, Rossella Marcucci, Manuel J Lievano Triana, Camilo Arana, Jose Accini, Rodrigo Botero, Marlena Muzyk-Osikowicz, Fredy T Dada, Gregorio S Vallejo, Fernando Manzur, Daniel Isaza, Dora Molina, Juan G Mesa, Alvaro Quintero, Kai Nyman, Jyrki Mäkelä, Jorma Strand, Sakari Nieminen, Jyrki Taurio, Matti Kuusela, Timo Valle, Mikko Pietilä, Sakari Kekki, Timo Strandberg, Marc Klutstein, Gabriel Greenberg, Yoseph Rozenman, Ehud Chorin, Ariel Roguin, Basil Lewis, Amir Bashkin, Edgar Tan, Jose P Prado, Arthur Ferrolino, Noe Babilonia, Benny Barbas, Generoso Matiga, Raul M Coching, Heinz Drexel, Helmut Brath, Christoph Schnack, Ursula Hanusch, Evelyn Fließer-Görzer, Bernhard Paulweber, Christoph Ebenbichler, Rudolf Prager, Kurt Huber, Michael Wolzt, Johann Auer, Rudolf Berger, Gerit-Holger Schernthaner, Gabriela Stanciulescu, Mihai Creteanu, Marilena Spiridon, Viorica Dobreanu, Dragos Vinereanu, Laura C Iosipescu, Octavian Istratoaie, Ioan Coman, Constantin Militaru, Mircea Cinteza, Peter R Sinnaeve, José C Nicolau, José F Kerr Saraiva, Ramón Corbalán, Petr Widimský, Steen D Kristensen, Juha Hartikainen, Harald Darius, Hung F Tse, Robert G Kiss, Prem Pais, Eli Lev, Leonardo de Luca, Gabriel A Ramos López, Frederic Kontny, Noe A Babilonia, Dmitry A Zateyshchikov, Mikhail Ruda, Omer Elamin, František Kovář, Anthony J Dalby, Héctor Bueno, Chern-En Chiang, Alexander Parkhomenko, Tuan Q Nguyen, Maria Leonsson-Zachrisson, Herrada, Anthony, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Royal Brompton Hospital, McMaster University [Hamilton, Ontario], Keenan Research Centre of the Li Ka Shing Knowledge Institute [Toronto], St. Michael's Hospital, University of Toronto, Service de Pharmacologie médicale = service de pharmacologie - Dosage de médicaments [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Uppsala University Hospital, Uppsala Universitet [Uppsala], AstraZeneca, Tokai University, Uppsala University, Imperial College London, Saint Luke's Mid America Heart Institute, University of Missouri [Kansas City] (UMKC), University of Missouri System, University of New South Wales [Sydney] (UNSW), University of Texas Southwestern Medical Center [Dallas], Stanford University, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, Rohr, K, Levinson, L, Gaona, R, Uretsky, B, Maheshwari, H, Lee, D, Kinnaman, S, Singal, R, Geohas, J, Gigliotti, O, Raisinghani, A, Khurana, C, Hella, B, Kelberman, M, Voyce, S, Singh, S, Lo, E, Singh, P, Goodfellow, R, Fischer, S, Lorraine, R, Turner, T, Shanes, J, Busch, R, Broker, R, Zaniewski, M, Pounds, K, Debs-Perez, G, Ong, S, Frandsen, B, Fullington, D, Jaffrani, N, Khan, A, 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Trenk, D, Weigmann, I, Reuter, H, Rummel, R, von Munchhausen, C, von Engelhardt, C, Horibe, E, Shibasaki, T, Sato, T, Kakuta, T, Michishita, I, Tan, M, Ishiki, R, Aoyama, T, Higashiue, S, Niijima, Y, Idogaki, A, Hasegawa, T, Kiyosue, A, Tomobuchi, Y, Kawamitsu, K, Kawasaki, S, Hata, Y, Fukui, K, Seki, K, Takenaka, T, Abe, M, Utsu, N, Oono, A, Mitsuo, K, Sueyoshi, A, Hirohata, A, Tsujimoto, M, Ueda, O, Takase, S, Suzuki, M, Sakuragi, S, Yamamoto, F, Fujimoto, N, Kakinoki, S, Sugiura, T, Sugino, H, Nakamura, T, Kadokami, T, Uehara, H, Ono, M, Yokoya, K, Koike, A, Komatsu, S, Sonoda, M, Ueno, H, Doi, T, Takagi, Y, Fujimoto, K, Eki, Y, Okubo, M, Sasaki, K, van Eck, M, Ronner, E, The, S, van de Wal, R, Nierop, P, de Nooijer, C, Werner, H, Westendorp, I, van der Zwaan, C, Crijns, H, Cornel, J, Strikwerda, S, Bos, R, de Melker, E, Kuijper, A, Louwerenburg, H, Plomp, J, Dantzig, J, Prins, F, van Kesteren, H, Willems, F, Amoroso, G, Carnero, G, Duronto, E, Besada, D, Chacon, C, Zangroniz, P, Solis, S, Liberman, A, Sernia, V, Alvarisqueta, A, Maffei, L, Vilamajo, O, Garcia, C, Sicer, M, Muntaner, J, Bordonava, A, Albisu, J, Zanini, A, Rista, L, Hominal, M, Estrada, J, Prado, A, Gosparini, D, Schiavi, B, Castillo, A, Martinez, G, Lopez, V, Rosas, E, Lopez, G, Cantu, E, de los Rios Ibarra, M, Padilla, F, Carrasco, J, Carrillo, L, Garcia, J, Askar, A, Salinas, C, Gamba, M, Sanchez, C, Cantu, A, Sanchez, R, Madrigal, J, Urbano, R, Romo, A, Gonzalez Juanatey, J, Racugno, P, Fillat, A, de la Torre Hernandez, J, Pelaez, J, Cortada, J, Pavia, P, Navarro, M, Asenjo, R, Diaz, F, Peligero, E, Manterola, F, Ortiz, A, Mediavilla Garcia, J, Ortuno, F, Vera, T, Gonzalez, A, Vinas, J, Fernandez Portales, F, Mayordomo, P, Ojeda, F, Dominguez, A, Gonzalez, R, Guerrero, D, Ruiz Nodar, J, Marimon, X, Margaez, J, Aguilera, R, Diaz Fernandez, J, Zamorano Gomez, J, Gonzalez, V, del Blanco, B, Perez, I, Moreno, M, Ereno, A, Garcia Lledo, J, Prieto, J, Villablanca, A, Raffo, C, Pincetti, C, Conejeros, C, Roman, O, Varleta, P, Goldberg, C, Sandoval, J, Arriagada, G, Corbalan, R, Leon, L, Potthoff, S, Cobos, J, Figueroa, C, Makotoko, E, Fourie, N, Burgess, L, Nortje, H, Theron, R, Pillai, P, Ranjith, N, Trokis, J, Pillay, S, Reddy, J, Nunkoo, T, Kapp, C, Urbach, D, Distiller, L, Horak, A, van Zyl, L, Coetzee, K, Punt, Z, Bayat, J, Dawood, S, Mitha, I, Padayachee, T, Hoosen, F, Dalby, A, Prabhavathi, Gowdaiah, P, Mehta, V, Chag, M, Gadkari, M, Ramamurthee, K, Das, A, Sawhney, J, Sathe, P, Adhyapak, S, Nguyen, T, Pham, V, Do, H, Nguyen, A, Nguyen, H, Truong, B, Jamil-Copley, S, Lang, C, Pell, A, Zaman, A, Storey, R, Swanson, N, Sharman, D, Braganza, D, Hammond, P, Moriarty, A, Bain, S, Pye, M, Sharp, A, Blagden, M, Randeva, H, Myhill, T, Viswanathan, G, Keeling, P, Clifford, P, Saxena, M, Lyons, K, Mcmurray, J, Jaafar, F, Murphy, C, Cartwright, S, Abouglila, K, Antalik, L, Krajci, P, Urban, M, Fazekas, F, Pella, D, Koleny, D, Vykoukalova, T, Macek, V, Vinanska, D, Jamriskova, L, Such, S, Fulop, P, Farsky, S, Bugan, V, Strbova, J, Micko, K, Palka Jr, J, Sivak, V, Kristensen, D, Refsgaard, J, Holmvang, L, Dixen, U, Nielsen, H, Egstrup, K, Jensen, L, Sykulski, R, Rasmussen, O, Andries, A, Luckow, A, Nielsen, G, Sorensen, T, Wongvipaporn, C, Chamnarnphol, N, Srimahachota, S, Sansanayudh, N, Kuanprasert, S, Tresukosol, D, Sookananchai, B, Kanadasi, M, Ozcan, T, Kucuk, M, Ongen, Z, Okuyan, E, Arat, A, Acikel, S, Yalcin, A, Guray, U, Ceyhan, C, Ozer, N, Arslan, S, Angeras, O, Johnston, N, Weiderman, A, Bandh, S, Hansen, O, Larnefeldt, H, Kusiak, D, Lindholm, C, Hedman, A, Erlinge, D, Curiac, D, Lundman, P, Zucconi-Mazzini, R, Aladellie, L, Jensen, J, Verwerft, J, Vrolix, M, Faes, D, Striekwold, H, Sinnaeve, P, Timmermans, P, Guedes, A, Delforge, M, Nimmegeers, J, Stammen, F, Buysschaert, I, Hoffer, E, Hollanders, G, Vervoort, G, Coussement, P, de Maeseneire, S, Janssens, L, Gravdal, S, Risberg, K, Gullestad, L, Hofseth, O, Nilsen, D, Lappegard, K, van den Heuvel, C, Gibbs, C, Khusrawi, A, Arora, S, Tomala, T, Kjaernli, T, Berg-Johansen, J, Hagemeier, R, Skjelvan, G, Colquhoun, D, Amerena, J, Morbey, C, Hammett, C, Dart, A, Lehman, R, Hamilton, A, Worthley, M, Purnell, P, Whelan, A, Macisaac, R, Arya, K, Linjawi, S, Proietto, J, Prasad, L, Rodriguez, A, Godoy, A, Rodriguez, V, Berrospi, P, Chavez, C, Negron, S, Heredia, J, Medina, F, Manrique, H, Cabrera, W, Cordova, F, Quinteros, T, Haro, J, Regalado, S, Guitton, J, Arbanil, H, Pansieri, M, Decoulx, E, Goube, P, de Labriolle, A, Labeque, J, Range, G, Cottin, Y, Montalescot, G, Cayla, G, Danchin, N, Angoulvant, D, Ferrario, E, Elbaz, M, Dubreuil, O, Fontaine, C, Sorbets, E, Omer, H, Al-Saif, S, Al-Faleh, H, Al-Shehri, A, El-Amin, O, Alshehri, H, Bazari, R, Hei, P, Ying, M, Chan, M, Wong, M, Ma, R, Siu, S, Tsang, C, Ferrario, M, Assanelli, E, Senni, M, Piatti, P, Calabro, P, Urbinati, S, Michisanti, M, Varbella, F, de Cosmo, S, Trevisan, R, Bellotti, S, Di Pasquale, G, Bongo, A, Uguccioni, M, Mannucci, E, Mauro, C, Ragonese, M, Fresco, C, Turturo, M, Marcucci, R, Lievano Triana, M, Arana, C, Accini, J, Botero, R, Muzyk-Osikowicz, M, Dada, F, Vallejo, G, Manzur, F, Isaza, D, Molina, D, Mesa, J, Quintero, A, Nyman, K, Makela, J, Strand, J, Nieminen, S, Taurio, J, Kuusela, M, Valle, T, Pietila, M, Kekki, S, Strandberg, T, Klutstein, M, Greenberg, G, Rozenman, Y, Chorin, E, Roguin, A, Lewis, B, Bashkin, A, Tan, E, Prado, J, Ferrolino, A, Babilonia, N, Barbas, B, Matiga, G, Coching, R, Drexel, H, Brath, H, Schnack, C, Hanusch, U, Fliesser-Gorzer, E, Paulweber, B, Ebenbichler, C, Prager, R, Huber, K, Wolzt, M, Auer, J, Berger, R, Schernthaner, G, Stanciulescu, G, Creteanu, M, Spiridon, M, Dobreanu, V, Vinereanu, D, Iosipescu, L, Istratoaie, O, Coman, I, Militaru, C, Cinteza, M, Nicolau, J, Kerr Saraiva, J, Widimsky, P, Kristensen, S, Hartikainen, J, Darius, H, Tse, H, Pais, P, Lev, E, de Luca, L, Ramos Lopez, G, Kontny, F, Zateyshchikov, D, Ruda, M, Elamin, O, Kovar, F, Bueno, H, Leonsson-Zachrisson, M, Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pharmacologie - Dosage de médicaments [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and Royal Brompton and Harefield NHS Foundation Trust-Imperial College London
- Subjects
Male ,Platelet Aggregation Inhibitors/therapeutic use ,THEMIS Steering Committee and Investigators ,medicine.medical_treatment ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,030204 cardiovascular system & hematology ,Coronary Angiography ,Stroke/epidemiology ,Coronary artery disease ,DOUBLE-BLIND ,0302 clinical medicine ,Hemorrhage/chemically induced ,acetylsalicylic acid, antidiabetic agent, placebo, ticagrelor ,Secondary Prevention ,Medicine ,030212 general & internal medicine ,Myocardial infarction ,Coronary Artery Bypass ,Cardiovascular Diseases/mortality ,11 Medical and Health Sciences ,OUTCOMES ,Aspirin ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,General Medicine ,Middle Aged ,Clopidogrel ,3. Good health ,Ticagrelor/therapeutic use ,DRUG-ELUTING STENTS ,CLOPIDOGREL ,Cardiology ,PLATELET INHIBITION ,Drug Therapy, Combination ,Female ,Life Sciences & Biomedicine ,Ticagrelor ,TIMI ,medicine.drug ,Coronary Artery Disease/complications ,medicine.medical_specialty ,Hypoglycemic Agents/therapeutic use ,POOLED ANALYSIS ,03 medical and health sciences ,Medicine, General & Internal ,Percutaneous Coronary Intervention ,Double-Blind Method ,General & Internal Medicine ,Internal medicine ,Myocardial Infarction/epidemiology ,Humans ,Aged ,Science & Technology ,ANTIPLATELET THERAPY ,business.industry ,Diabetes Mellitus, Type 2/complications ,ELEVATION MYOCARDIAL-INFARCTION ,RIVAROXABAN ,Percutaneous coronary intervention ,medicine.disease ,ASPIRIN ,Coronary Stenosis/diagnostic imaging ,Aspirin/therapeutic use ,Conventional PCI ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Contains fulltext : 215333.pdf (Publisher’s version ) (Closed access) BACKGROUND: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. METHODS: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). FINDINGS: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3.3 years (IQR 2.8-3.8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7.3%] of 5558 vs 480 [8.6%] of 5596; HR 0.85 [95% CI 0.74-0.97], p=0.013). The same effect was not observed in patients without PCI (p=0.76, pinteraction=0.16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3.1%] with ticagrelor vs 183 (3.3%) with placebo; HR 0.96 [95% CI 0.78-1.18], p=0.68), as well as all-cause death (282 [5.1%] vs 323 [5.8%]; 0.88 [0.75-1.03], p=0.11). TIMI major bleeding occurred in 111 (2.0%) of 5536 patients receiving ticagrelor and 62 (1.1%) of 5564 patients receiving placebo (HR 2.03 [95% CI 1.48-2.76], p
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- 2019
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46. Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen.
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Rodosthenous RS, Niemi MEK, Kallio L, Perala M, Terho P, Knopp T, Punkka E, Makkonen EM, Nurmi P, Makela J, Wihuri P, Hautalahti M, Moffatt C, Martini P, Germine L, Makela VA, Karhunen OA, Lahti J, Hiekkalinna TS, Jyrhama T, Shen HY, Runz H, Palotie A, Perola M, and Ganna A
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- Adolescent, Cognition, Humans, Life Style, Pilot Projects, Surveys and Questionnaires, Biological Specimen Banks, Duty to Recontact
- Abstract
Objectives: To recontact biobank participants and collect cognitive, behavioural and lifestyle information via a secure online platform., Design: Biobank-based recontacting pilot study., Setting: Three Finnish biobanks (Helsinki, Auria, Tampere) recruiting participants from February 2021 to July 2021., Participants: All eligible invitees were enrolled in FinnGen by their biobanks (Helsinki, Auria, Tampere), had available genetic data and were >18 years old. Individuals with severe neuropsychiatric disease or cognitive or physical disabilities were excluded. Lastly, 5995 participants were selected based on their polygenic score for cognitive abilities and invited to the study. Among invitees, 1115 had successfully participated and completed the study questionnaire(s)., Outcome Measures: The primary outcome was the participation rate among study invitees. Secondary outcomes included questionnaire completion rate, quality of data collected and comparison of participation rate boosting strategies., Results: The overall participation rate was 18.6% among all invitees and 23.1% among individuals aged 18-69. A second reminder letter yielded an additional 9.7% participation rate in those who did not respond to the first invitation. Recontacting participants via an online healthcare portal yielded lower participation than recontacting via physical letter. The completion rate of the questionnaire and cognitive tests was high (92% and 85%, respectively), and measurements were overall reliable among participants. For example, the correlation (r) between self-reported body mass index and that collected by the biobanks was 0.92., Conclusion: In summary, this pilot suggests that recontacting FinnGen participants with the goal to collect a wide range of cognitive, behavioural and lifestyle information without additional engagement results in a low participation rate, but with reliable data. We suggest that such information be collected at enrolment, if possible, rather than via post hoc recontacting., Competing Interests: Competing interests: MEKN is a full-time employee at Novartis and HR is a full-time employee at Biogen., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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47. Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response.
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Kukkonen K, Taavitsainen S, Huhtala L, Uusi-Makela J, Granberg KJ, Nykter M, and Urbanucci A
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The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. In this review, we collect and assess evidence on the contribution of chromatin and epigenetic dysregulation in prostate cancer. We highlight important mechanisms leading to prostate carcinogenesis, the emergence of castration-resistance upon treatment with androgen deprivation therapy, and resistance to antiandrogens. We examine in particular the contribution of chromatin structure and epigenetics to cell lineage commitment, which is dysregulated during tumorigenesis, and cell plasticity, which is altered during tumor progression.
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- 2021
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48. Short-term Revision Risk of Patellofemoral Arthroplasty Is High: An Analysis from Eight Large Arthroplasty Registries.
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Lewis PL, Tudor F, Lorimer M, McKie J, Bohm E, Robertsson O, Makela KT, Haapakoski J, Furnes O, Bartz-Johannessen C, Nelissen RGHH, Van Steenbergen LN, Fithian DC, and Prentice HA
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- Arthroplasty, Replacement, Knee instrumentation, Australia, Biomechanical Phenomena, Canada, Female, Humans, Knee Prosthesis, Male, Middle Aged, New Zealand, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee physiopathology, Patellofemoral Joint diagnostic imaging, Patellofemoral Joint physiopathology, Postoperative Complications diagnostic imaging, Postoperative Complications physiopathology, Prosthesis Failure, Recovery of Function, Registries, Risk Assessment, Risk Factors, Scandinavian and Nordic Countries, Therapeutics, Time Factors, Arthroplasty, Replacement, Knee adverse effects, Osteoarthritis, Knee surgery, Patellofemoral Joint surgery, Postoperative Complications surgery, Reoperation adverse effects
- Abstract
Background: Patellofemoral arthroplasty (PFA) is one option for the treatment of isolated patellofemoral osteoarthritis, but there are limited data regarding the procedure and results. Because isolated patellofemoral arthritis is relatively uncommon, available case series generally are small, and even within national registries, sample sizes are limited. Combining data from multiple registries may aid in assessing worldwide PFA usage and survivorship., Questions/purposes: We combined and compared data from multiple large arthroplasty registries worldwide to ask: (1) What proportion of patients undergoing primary knee arthroplasty have PFA? (2) What are the patient and prosthesis characteristics associated with PFA in common practice, as reflected in registries? (3) What is the survivorship free from revision of PFA and what are the reasons for and types of revisions?, Methods: Data were provided by eight registries that are members of the International Society of Arthroplasty Registries (ISAR) who agreed to share aggregate data: Australia, New Zealand, Canada, Sweden, Finland, Norway, the Netherlands, and the United States. De-identified data were obtained for PFA performed from either the beginning of year 2000, or the earliest recorded implantation date after that in each individual registry when PFA data collection commenced, up to December 31, 2016. This included patient demographics, implant use, all-cause revision rate (determined by cumulative percent revision [CPR]), and reasons for and type of revision., Results: During the data collection period, 6784 PFAs were performed in the eight countries. PFAs comprised less than 1% of primary knee replacements in all registries. Patient demographics were comparable in all countries. Patients were generally more likely to be women than men, and the mean age ranged from 50 years to 60 years. All registries showed a high rate of revision for PFA. The 5-year CPR for any reason ranged from 8.0% (95% CI 4.5 to 11.5) in Norway to 18.1% (95% CI 15.5 to 20.7) in the Netherlands. The most common reason for revision across all countries was disease progression (42%, 434 of 1034). Most PFAs (83%, 810 of 980) were revised to a TKA., Conclusions: The revision risk of PFA in all registries surveyed was more than three times higher than the reported revision risk of TKA at the same times. The survivorship of PFA is similar to that of the no-longer-used procedure of metal-on-metal conventional hip replacement. Although there may be potential functional benefits from PFA, these findings of consistent and alarmingly high rates of revision should create concern, particularly as this procedure is often used in younger patients., Level of Evidence: Level III, therapeutic study.
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- 2020
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