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Your search keyword '"Malcolm Allan"' showing total 3 results
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3 results on '"Malcolm Allan"'

1. Process Development, Manufacture, and Understanding of the Atropisomerism and Polymorphism of Verinurad

Author

Lucie Miller-Potucka, Gall Malcolm Allan Young, Ian W. Ashworth, Andrew J. Robbins, Oliver T. Ring, Martin F. Jones, Barry R. Hayter, Rosemary A. Wordsworth, Adam J. Leahy, Lyn Powell, Phillip A. Inglesby, Alex L. Lamacraft, Okky Dwichandra Putra, Janette H. Cherryman, Thomas O. Ronson, Peter R. Hamilton, Simone Tomasi, Lauren R. Agnew, and David C. McKinney

Subjects
Genetics, Atropisomer, Polymorphism (computer science), Chemistry, Process development, Organic Chemistry, Physical and Theoretical Chemistry
Published
2021
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3. Process Design and Optimization in the Pharmaceutical Industry: A Suzuki-Miyaura Procedure for the Synthesis of Savolitinib

Author

Gareth P. Howell, Michael John Pilling, Andrew Hornby Dobson, Lucie Miller-Potucka, Lauren R. Agnew, Robert J Cox, Brian A. Taylor, Adlington Neil Keith, Aled Williams, William Hicks, Gall Malcolm Allan Young, Andrew D. Campbell, Anna Jawor-Baczynska, Katy Shepherd, Cristina Fernandez Barrat, and Ross Tassone

Subjects
Drug Industry, Molecular Structure, 010405 organic chemistry, Process (engineering), business.industry, Chemistry, Triazines, Organic Chemistry, Process design, 010402 general chemistry, 01 natural sciences, Manufacturing engineering, 0104 chemical sciences, High-Throughput Screening Assays, Drug Design, Pyrazines, business, Drug industry, Pharmaceutical industry
Abstract

A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki–Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.

Published
2018

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